Elavil
(Amitriptyline)ApprovedSmall molecule
AstraZenecaAmitriptyline is used to treat depression by increasing amounts of certain natural chemicals in the brain needed for mental balance. It belongs to a class of older antidepressants and may also be used for nerve pain, eating disorders, and migraine prevention.[2] Elavil is currently approved and in use across 25 indications[4].[1]
Elavil is one of 433 small molecule programs targeting Intervertebral Disc Displacement. It is currently in Approved.
25
Indications
73
Total Trials
10
Active Trials
432
Competitors
2
FDA Applications
NDA/BLA/ANDA regulatory filings
Pipeline
Status by Indication[4][1]
Indication
Showing 10 of 24 indications
Competition
Competitive Landscape
102 competitors in Migraine
#DrugCompanyPhaseTrials
1Elavil
AstraZenecaApproved
Avicel
SSanthera Pharmaceuticals
Phase 3
Effient
CCosette Pharmaceuticals, Inc.
Phase 3
Magnesium
SSpherium Biomed
Phase 3
Triptans
PfizerPhase 3
Aspirin /d
TThe First Affiliated Hospital with Nanjing Medical University
Phase 3
Flunarizine
AAspartes Pharmaceuticals, Inc.
Phase 3
Bayer Aspirin
BayerPreclinical
Cervidil
PfizerPreclinical
Adempas
BayerPreclinical
Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.
Timeline
Expected Milestones
Clinical
Trials by Indication[1]
Migraine12 trials
Comparison of the Effectiveness of First-line Preventive Treatment of Migraine in Primary Care
Not yet recruiting·FFundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina·Phase 4·NCT06499116·460 enrolled
Mind and Body Approaches to Pain Reduction in Youth With Migraine
Completed·—·Phase 2·NCT03472092·132 enrolled
Show 9 more trials
The Childhood and Adolescent Migraine Prevention Study
Terminated·—·Phase 3·NCT01581281·488 enrolled
Amitriptyline vs GON and SON Blocks in Migraine
Completed·—·N/A·NCT04750967·57 enrolled
Topiramate, Amitriptyline Monotherapy and Combination Therapy in Migraine Prophylaxis
Unknown status·—·Phase 4·NCT05759845·150 enrolled
Efficacy of Flunarizine Vs Amitriptyline in Prophylaxis of Migraine Prophylaxis
Unknown status·—·N/A·NCT06162819·84 enrolled
Treatment7 trials
Trial of the Treatment of Chronic Laryngitis With Amitryptiline
Terminated·—·Phase 2/3·NCT02434523·30 enrolled
Treatment of Chronic Laryngitis With Amitriptyline
Terminated·—·Phase 2/3·NCT02552225·6 enrolled
Show 4 more trials
Sham Device, Pill Placebo or Treatment For Arm Pain
Completed·NNational Center for Complementary and Integrative Health (NCCIH)·Phase 2·NCT00029497·240 enrolled
Fibromyalgia4 trials
Headache4 trials
Pediatric Chronic Headache Trial
Unknown status·—·Phase 3·NCT00389038·132 enrolled
Neuropathic Pain4 trials
Show 1 more trial
39 more indications
Major Depressive Disorder2 trials
Irritable Bowel Syndrome2 trials
Conditioning1 trial
Medication1 trial
Pain1 trial
Prospective1 trial
Laparoscopic Cholecystectomy1 trial
Trial of Laparoscopic Cholecystectomy vs. Non-operative Treatment for Gallbladder Dyskinesia
Unknown status·—·Phase 2·NCT02195115·60 enrolled
Spinal Cord Injury1 trial
Chronic Pain in Spinal Cord Injury
Completed·EEunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)·Phase 4·NCT00006428·100 enrolled
RCT1 trial
EA for BPS: an RCT and Study for Central Mechanism
Recruiting·TThe Third Affiliated hospital of Zhejiang Chinese Medical University·N/A·NCT05279963·84 enrolled
Adjuvant Treatment1 trial
Painful Bladder Syndrome1 trial
Efficacy of Amitriptyline for Painful Bladder Syndrome (PBS)
Completed·NNational Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)·Phase 3·NCT00124306·271 enrolled
Major Depression1 trial
Amitriptyline and Paroxetine Treatment of Major Depression
Completed·—·Phase 3·NCT01049347·127 enrolled
Adhesive Capsulitis1 trial
Amitriptyline Regarding Nimesulide in Acute Idiopathic Adhesive Capsulitis
Completed·—·Phase 2·NCT01306708·34 enrolled
Female1 trial
Hysterectomy1 trial
Ketamine1 trial
Effect of Ketamine, Amitriptyline and Their Combination on Itch
Completed·—·N/A·NCT06245564·30 enrolled
Abdominal pain1 trial
Study of Medication for Functional Abdominal Pain in Children
Completed·—·Phase 4·NCT00564525·95 enrolled
Cystic Fibrosis1 trial
Interstitial Lung Disease1 trial
Chronic Cough1 trial
Tics1 trial
A Genotype Stratification Study for Pharmacokinetics and Pharmacodynamics of Amitriptyline in Healthy Male Subjects
Unknown status·—·Phase 1·NCT02519400·24 enrolled
Rosacea1 trial
Cognition1 trial
Chronic pain1 trial
Chronic Pain After Amputation
Completed·EEunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)·Phase 4·NCT00006427·125 enrolled
Children1 trial
Trial of Amitriptyline for Chronic Oral Food Refusal in Children 9 Months to 8 Years of Age
Completed·—·Phase 2·NCT01206478·21 enrolled
Microvesicle Particles1 trial
Unspecified2 trials
The Influence of Amitriptyline on Learning in a Visual Discrimination Task
Completed·—·N/A·NCT01566825·32 enrolled
Regulatory
FDA Approval Timeline[5]
Jan 1, 1982
ELAVIL
NDA NDA012704
Jan 1, 1982
ELAVIL
NDA NDA012703
Sources
References
- [1]
- [2]MedlinePlus Drug Information — Elavil drug information. U.S. National Library of Medicine, National Institutes of Health.
- [3]
- [4]Open Targets Platform — Drug–disease associations for Amitriptyline. EMBL-EBI & Wellcome Sanger Institute.
- [5]
- [6]
Details
Drug Info
Quick Facts
- Mechanism of Action
- Norepinephrine Transporter Inhibitor; Serotonin Transporter Inhibitor[3]
- Modality
- Small molecule[3]
- Highest Phase
- Approved[1]
- Company