Vancocin

(Vancomycin)

ApprovedSmall molecule

Vancomycin is an antibiotic used to treat serious bacterial infections, particularly those caused by bacteria that are resistant to other common antibiotics like methicillin-resistant Staphylococcus aureus (MRSA).[2] Vancocin is currently approved and in use across 67 indications[4].[1]

Vancocin is one of 835 small molecule programs targeting Respiratory Tract Infectious Disorder. It is currently in Approved.

Indications

277

Total Trials

Active Trials

834

Competitors

FDA Applications

NDA/BLA/ANDA regulatory filings

Patents

Pipeline

Status by Indication[4][1]

Indication

Respiratory Tract Infectious DisorderActive, not recruiting

Bacterial DiseaseActive, not recruiting

ArthropathyApproved

Metastatic MelanomaApproved

Subarachnoid HemorrhageActive, not recruiting

Staphylococcal Skin InfectionsActive, not recruiting

Revision of Total Knee ArthroplastyActive, not recruiting

AntibioticsTerminated

Ulcerative Colitis (UC)Not yet recruiting

Vaccine Response ImpairedRecruiting

Respiratory Tract Infectious DisorderApproved

Active, not recruiting

Bacterial DiseaseApproved

Active, not recruiting

ArthropathyApproved

Approved

Metastatic MelanomaApproved

Approved

Subarachnoid HemorrhagePreclinical

Active, not recruiting

Staphylococcal Skin InfectionsPreclinical

Active, not recruiting

Revision of Total Knee ArthroplastyPreclinical

Active, not recruiting

AntibioticsApproved

Terminated

Ulcerative Colitis (UC)Phase 2

Not yet recruiting

Vaccine Response ImpairedApproved

Recruiting

Showing 10 of 64 indications

Competition

Competitive Landscape

414 competitors in Non-Small Cell Lung Cancer

#DrugCompanyPhaseTrials

Vancocin

HHikma Pharmaceuticals LLC

Approved

1 2

Arimidex

IIstituto Clinico Humanitas

Phase 3

3 3

Serplulimab

Shanghai Henlius Biotech

Phase 3

5 4

Firmonertinib

AAllist Pharmaceuticals, Inc.

Phase 3

2 5

Remeron

OOrganon and Co

Preclinical

1 6

Aqupla

Jiangsu Simcere Pharmaceutical Co., Ltd.

Preclinical

—7

Ftorafur

TThe First Affiliated Hospital with Nanjing Medical University

Preclinical

—8

Vibramycin

PPfizer's Upjohn has merged with Mylan to form Viatris Inc.

Treatment

1 10

PD-1 Inhibitors

BBioNTech US Inc.

Preclinical

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q4 2026

Phase 3Recruiting

Surgical Site Infection

NCT05959603

N/ANot yet recruiting

Infection

NCT06702345

Phase 2Recruiting

Probiotic Intervention

NCT07207434

Q3 2027

Phase 1Active, not recruiting

Melanoma

NCT06540391

Q4 2027

Post-ApprovalRecruiting

Total Ankle Arthroplasty

NCT06384651

Q1 2028

N/ANot yet recruiting

Vancomycin

NCT06373640

Clinical

Trials by Indication[1]

Vancomycin20 trials

The Influencing Factors of Vancomycin Trough Level and the Rate Achieving the Target Trough Level

Completed·SSoutheast University, China··NCT03806543·165 enrolled

A Phase 2a Study, Effect of Vancomycin With vs Without Delpazolid (LCB01-0371) in Patients With MRSA Bacteremia

Terminated·LLigaChem Biosciences, Inc.·Phase 2·NCT05225558·40 enrolled

Model-informed Precision Dosing of Vancomycin in Adults

Completed·UUniversity Hospital, Ghent·Phase 4·NCT05535075·155 enrolled

Show 17 more trials

Haemoglobin And Vancomycin Pharmacokinetics in the Cerebrospinal Fluid Following Subarachnoid Haemorrhage

Not yet recruiting·UUniversity Hospital Southampton NHS Foundation Trust·N/A·NCT06373640·14 enrolled

Vancomycin vs. Vancomycin Plus Gentamycin in Treatment of MRSA Infection

Completed·MMichael E. DeBakey VA Medical Center·Phase 4·NCT00304811·160 enrolled

Oral Vancomycin Followed by Fecal Transplant Versus Tapering Oral Vancomycin

Terminated·UUniversity Health Network, Toronto·Phase 2/3·NCT01226992·81 enrolled

Exploring Vancomycin Disposition in Neonates

Recruiting·UUniversitaire Ziekenhuizen KU Leuven·Phase 4·NCT02096536·120 enrolled

The Effects of Daptomycin and Cytokines Production in Comparison With Vancomycin

Completed·HHospital Universitario Evangelico de Curitiba·Phase 4·NCT01626560·20 enrolled

Vancomycin in the Target Site Treatment of Intracranial Infection

Unknown status·XXijing Hospital·Phase 4·NCT03585426·2 enrolled

Pharmacokinetics/ Pharmacodynamics (PK/PD) Study of Vancomycin

Unknown status·ZZhejiang University·Phase 4·NCT02443064·100 enrolled

Neonatal Vancomycin Trial

Terminated·PPENTA Foundation·Phase 2·NCT02790996·242 enrolled

Loading Vancomycin Doses in the Emergency Department

Completed·CChristiana Care Health Services·N/A·NCT01162733·99 enrolled

Pharmacokinetics Vancomycin CVVHDF with OXiris Membrane

Recruiting·MMahidol University·N/A·NCT06543940·8 enrolled

First Time Right of Vancomycin

Not yet recruiting·EErasmus Medical Center·N/A·NCT05964114·134 enrolled

Infection Rates Between Using of Vancomycin Versus Gentamycin in Primary ACLR

Unknown status·—··NCT06050785·110 enrolled

Effect of Vancomycin After Catheter Replacement

Unknown status·UUniversity of Zurich·Phase 4·NCT04856878·100 enrolled

Treatment Algorithm to Reduce the Use of Vancomycin in Adults With Blood Stream Infection

Completed·—·Phase 2·NCT01191840·509 enrolled

IO Vancomycin Spine

Not yet recruiting·TThe Methodist Hospital Research Institute·Phase 2/3·NCT06748144·30 enrolled

IO vs IV Vancomycin in Tourniquetless TKA

Unknown status·TThe Methodist Hospital Research Institute·Phase 4·NCT05705843·40 enrolled

Vancomycin for the Treatment of NAAT(+)/Toxin(-) C. Difficile

Completed·MMedical College of Wisconsin·Phase 1·NCT03827447·7 enrolled

Clostridium Difficile Infection14 trials

Oral Vancomycin Versus Probiotics Versus Placebo for Prevention of Clostridium Difficile Infection in Colonized Patients

Withdrawn·HHamilton Health Sciences Corporation·Phase 1·NCT04246151

Fecal Transplantation for Primary Clostridium Difficile Infection

Terminated·OOslo University Hospital·Phase 3·NCT03796650·104 enrolled

A Post-marketing, Blinded Study to Investigate How Effective Fidaxomicin is Compared to Vancomycin in the Sustained Cure of Clostridium Difficile Infection in Adults That Are Receiving Therapy to Suppress the Immune System

Terminated· Astellas logo

Astellas·Phase 4·NCT01775397·12 enrolled

Show 11 more trials

Use Of Oral Fidaxomicin Vs. Oral Vancomycin For Clostridium Difficile Infection In Patients With Spinal Cord Injury

Terminated·—·Phase 4·NCT02355938·12 enrolled

Fecal Microbiota Transplantation for Relapsing Clostridium Difficile Infection

Completed·UUniversity of Aarhus·Phase 3·NCT02743234·64 enrolled

Efficacy of Oral Vancomycin Prophylaxis for Prevention of Recurrent Clostridium Difficile Infection

Completed·UUniversity of Wisconsin, Madison·Phase 2·NCT03462459·79 enrolled

Study of CB-183,315 in Participants With Clostridium Difficile Infection

Completed· Merck & Co. logo

Merck & Co.·Phase 2·NCT01085591·210 enrolled

Treatment of Initial Clostridium Difficile Infection

Completed·UUniversidad Autonoma de Nuevo Leon·N/A·NCT03107169·10 enrolled

Fecal Microbiota Therapy for Recurrent Clostridium Difficile Infection

Unknown status·QQueen Elizabeth II Health Sciences Centre·Phase 2/3·NCT02686645·50 enrolled

Vancomycin Prophylaxis in Recurrent Clostridium Difficile Infection

Unknown status·CCorewell Health West·Phase 4·NCT02237859·140 enrolled

MET-2 Clinical Study for Recurrent Clostridium Difficile Infection (CDI)

Completed·NNuBiyota·Phase 1·NCT02865616·19 enrolled

Initial Vancomycin Taper for the Prevention of Recurrent Clostridium Difficile Infection

Completed·MMcGill University Health Centre/Research Institute of the McGill University Health Centre·Phase 3·NCT04138706·263 enrolled

Screening to Prophylax Against Clostridium Difficile Infection -

Completed·CCorewell Health East·Phase 4·NCT02996487·1,294 enrolled

Fecal Microbiota Transplantation for Severe Clostridium Difficile Infection

Completed·—·Phase 2·NCT03427229·58 enrolled

Diarrhea13 trials

A Study of CB-183,315 in Participants With Clostridium Difficile Associated Diarrhea (MK-4261-006)

Completed· Merck & Co. logo

Merck & Co.·Phase 3·NCT01598311·608 enrolled

Efficacy and Safety of Cadazolid Versus Vancomycin in Subjects With Clostridium Difficile - Associated Diarrhea

Completed· Johnson & Johnson logo

Johnson & Johnson·Phase 3·NCT01987895·632 enrolled

Study of CB-183,315 in Participants With Clostridium Difficile Associated Diarrhea (MK-4261-005)

Completed· Merck & Co. logo

Merck & Co.·Phase 3·NCT01597505·606 enrolled

Show 10 more trials

PAR-101/OPT-80 Versus Vancomycin for the Treatment of Clostridium Difficile-Associated Diarrhea (CDAD)

Completed· Merck & Co. logo

Merck & Co.·Phase 3·NCT00468728·535 enrolled

Transplantation of Cultured Gut Microflora to Repeat Antibiotic-induced Diarrhea Due to Clostridium Difficile

Completed·PPer Hellström·Phase 2·NCT02857582·60 enrolled

Fidaxomicin Versus Vancomycin for the Treatment of Clostridium Difficile-Associated Diarrhea (CDAD) (MK-5119-018)

Completed· Merck & Co. logo

Merck & Co.·Phase 3·NCT00314951·629 enrolled

A Trial to Compare Xifaxan to Vancomycin for the Treatment of Clostridium Difficile-Associated Diarrhea (CDAD)

Completed·BBausch Health Americas, Inc.·Phase 3·NCT00269399·237 enrolled

A Study to Compare Safety and Efficacy of OPT-80(Fidaxomicin) With Vancomycin in Subjects With Clostridium Difficile-associated Diarrhea (CDAD)

Completed· Astellas logo

Astellas·Phase 3·NCT02179658·210 enrolled

Fecal Microbiota Transplantation for Primary Clostridium Difficile Diarrhea

Withdrawn·MMemorial University of Newfoundland·Phase 3·NCT02801656

Efficacy and Safety of Cadazolid Versus Vancomycin in Subjects With Clostridium Difficile-associated Diarrhea

Completed· Johnson & Johnson logo

Johnson & Johnson·Phase 3·NCT01983683·631 enrolled

Efficacy, Safety and Tolerability of Cadazolid in Subjects With Clostridium Difficile Associated Diarrhea (CDAD)

Completed· Johnson & Johnson logo

Johnson & Johnson·Phase 2·NCT01222702·84 enrolled

Comparison of Cadazolid Versus Vancomycin in Children With Clostridium Difficile-associated Diarrhea (CDAD)

Terminated· Johnson & Johnson logo

Johnson & Johnson·Phase 2/3·NCT03105479·1 enrolled

A Study to Investigate the Safety and Efficacy of Fidaxomicin (Oral Suspension or Tablets) and Vancomycin (Oral Liquid or Capsules) in Pediatric Subjects With Clostridium Difficile-associated Diarrhea (CDAD)

Completed· Astellas logo

Astellas·Phase 3·NCT02218372·148 enrolled

Pneumonia7 trials

Aerosolized Vancomycin in Methicillin-Resistant Staphylococcus Aureus Pneumonia Under Mechanical Ventilation

Completed·SSeoul National University Hospital·Phase 2·NCT01925066·20 enrolled

Evaluation of Patients With Methicillin-Resistant Staphylococcus Aureus Hospital-Acquired Pneumonia Treated With Linezolid or Vancomycin

Completed· Pfizer logo

Pfizer··NCT01561469·188 enrolled

Nosocomial Pneumonia With Suspected Or Proven Methicillin-Resistant Staphylococcus Aureus (MRSA)

Completed· Pfizer logo

Pfizer·Phase 4·NCT00084266·1,225 enrolled

Show 4 more trials

Clinical Outcomes of Methicillin Resistant Staphylococcus Aureus (MRSA) Hospital-Based Pneumonia

Completed· Pfizer logo

Pfizer··NCT01819935·5,271 enrolled

Clinical Efficacy of Intravenous Iclaprim Versus Vancomycin in the Treatment of Hospital-Acquired, Ventilator-Associated, or Health-Care-Associated Pneumonia

Terminated·AArpida AG·Phase 2·NCT00543608·135 enrolled

Comparison of Telavancin and Vancomycin for Hospital-acquired Pneumonia Due to Methicillin-resistant Staphylococcus Aureus

Completed·CCumberland Pharmaceuticals·Phase 3·NCT00107952·761 enrolled

Comparison of Telavancin and Vancomycin for Hospital-acquired Pneumonia Due to Methicillin-resistant Staphylococcus Aureus

Completed·CCumberland Pharmaceuticals·Phase 3·NCT00124020·771 enrolled

Infections7 trials

Study Comparing Cubicin With Vancomycin in Treatment of Participants With Complicated Skin and Skin Structure Infections in a Home Infusion Setting

Terminated· Merck & Co. logo

Merck & Co.·Phase 4·NCT01175707·80 enrolled

Evaluation of Daptomycin for the Emergency Department Treatment of Complicated Skin and Skin Structure Infections

Completed·UUniversity of Cincinnati·Phase 4·NCT01549613·104 enrolled

Dalbavancin for the Treatment of Acute Bacterial Skin and Skin Structure Infections in Children, Known or Suspected to be Caused by Susceptible Gram-positive Organisms, Including MRSA

Completed· AbbVie logo

AbbVie·Phase 3·NCT02814916·199 enrolled

Show 4 more trials

Delafloxacin vs Vancomycin and Aztreonam for the Treatment of Acute Bacterial Skin and Skin Structure Infections

Completed·MMelinta Therapeutics, Inc.·Phase 3·NCT01984684·850 enrolled

Intestinal Lavage for the Treatment of Severe C. Difficile Infections

Unknown status·LLondon Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's·Phase 2/3·NCT02466698·20 enrolled

Antibiotic Treatment for Infections of Short Term In-dwelling Vascular Catheters Due to Gram Positive Bacteria

Completed· Pfizer logo

Pfizer·Phase 3·NCT00037050·739 enrolled

Delafloxacin Versus Vancomycin and Aztreonam for the Treatment of Acute Bacterial Skin and Skin Structure Infections

Completed·MMelinta Therapeutics, Inc.·Phase 3·NCT01811732·660 enrolled

85 more indications

Skin Infection6 trials

China Registration Study in Patients With Skin Infections

Completed· AstraZeneca logo

AstraZeneca·Phase 3·NCT00772447·265 enrolled

Evaluation of Ceftaroline Fosamil vs Vancomycin Plus Aztreonam in the Treatment of Patients With Skin Infections.

Terminated· Pfizer logo

Pfizer·Phase 3·NCT02202135·4 enrolled

A Study to Assess Objective Endpoint Measurements of Response in Bacterial Skin Infections

Completed·MMelinta Therapeutics, Inc.·Phase 2·NCT01283581·256 enrolled

Show 3 more trials

Daptomycin Versus Vancomycin in Participants With Skin Infections Due to MRSA

Completed· Merck & Co. logo

Merck & Co.·Phase 4·NCT01419184·250 enrolled

Evaluation of Ceftaroline Fosamil Versus Vancomycin Plus Aztreonam in the Treatment of Patients With Skin Infections

Completed· Pfizer logo

Pfizer·Phase 3·NCT01499277·802 enrolled

Study of Debio 1450 for Bacterial Skin Infections

Completed·DDebiopharm International SA·Phase 2·NCT02426918·330 enrolled

Methicillin-resistant Staphylococcus Aureus5 trials

Prevention of Gastrostomy-Related Wound Infection by Vancomycin in Carriers of Methicillin-Resistant Staphylococcus Aureus.

Unknown status·UUniversity Hospital, Geneva·Phase 2·NCT00150852·96 enrolled

Skin Structure Infections With Suspected or Proven Methicillin-Resistant Staphylococcus Aureus (MRSA)

Completed· Pfizer logo

Pfizer·Phase 4·NCT00087490·1,077 enrolled

Comparison of Telavancin and Vancomycin for Complicated Skin and Skin Structure Infections With a Focus on Methicillin-resistant Staphylococcus Aureus

Completed·CCumberland Pharmaceuticals·Phase 3·NCT00107978·1,035 enrolled

Show 2 more trials

Vancomycin Versus Daptomycin for the Treatment of Methicillin-resistant Staphylococcus Aureus Bacteremia Due to Isolates With High Vancomycin Minimum Inhibitory Concentrations (MICs)

Terminated·SSt. John Health System, Michigan·Phase 4·NCT01287832·11 enrolled

Comparison of Telavancin and Vancomycin for Complicated Skin and Skin Structure Infections With a Focus on Methicillin-resistant Staphylococcus Aureus

Completed·CCumberland Pharmaceuticals·Phase 3·NCT00091819·862 enrolled

Safety and Efficacy5 trials

Phase 3 Study to Evaluate Safety and Efficacy of Iclaprim Versus Vancomycin for ABSSSI: REVIVE-2

Completed·MMotif Bio·Phase 3·NCT02607618·613 enrolled

Phase 3 Study to Evaluate Safety and Efficacy of Iclaprim Versus Vancomycin for ABSSSI: REVIVE-1

Completed·MMotif Bio·Phase 3·NCT02600611·600 enrolled

Phase 2 Safety and Efficacy Study of Daptomycin in Complicated Skin and Skin Structure Infections

Completed· Merck & Co. logo

Merck & Co.·Phase 2·NCT00426933·100 enrolled

Show 2 more trials

Study of Daptomycin Safety and Efficacy for Complicated Skin and Skin Structure Infections (cSSSI) and Bacteremia in Renal Impairment

Terminated· Merck & Co. logo

Merck & Co.·Phase 4·NCT01104662·92 enrolled

Study Comparing the Safety and Efficacy of Two Doses of BC-3781 vs Vancomycin in Patients With Acute Bacterial Skin and Skin Structure Infection (ABSSSI)

Completed·NNabriva Therapeutics AG·Phase 2·NCT01119105·210 enrolled

Osteomyelitis5 trials

Drug Delivery Devices for Osteomyelitis

Completed·—··NCT02968693·51 enrolled

Study of Daptomycin in Subjects Undergoing Surgery for Osteomyelitis Associated With an Infected Prosthetic Caused by Staphylococci

Completed· Merck & Co. logo

Merck & Co.·Phase 2·NCT00428844·75 enrolled

Vancomycin Or Trimethoprim/Sulfamethoxazole for Methicillin-resistant Staphylococcus Aureus Osteomyelitis

Completed·UUniversity of Washington·Phase 3·NCT00324922·2 enrolled

Show 2 more trials

Prospective, Randomized, Multicenter Clinical Trial of Bisphosphonates Combined With Vancomycin for the Treatment of Cierny-Mader Type I and III Osteomyelitis

Not yet recruiting·SSecond Affiliated Hospital, School of Medicine, Zhejiang University·Phase 3·NCT07435051·280 enrolled

Safety and Efficacy Study of Daptomycin Compared to Active Comparator in Pediatric Participants With Acute Hematogenous Osteomyelitis (AHO) (MK-3009-006)

Completed· Merck & Co. logo

Merck & Co.·Phase 3·NCT01922011·149 enrolled

Antibiotic5 trials

AbioKin - Antibiotic Kinetics

Completed·GGruppo Italiano per la Valutazione degli Interventi in Terapia Intensiva··NCT02609646·1,500 enrolled

Impact of Oral Antibiotic Treatment on C. Difficile

Completed·—·Phase 4·NCT02057198·33 enrolled

Comparison of Teicoplanin and Vancomycin in Initial Empirical Antibiotic Regimen for Febrile Neutropenic Patients

Completed· Sanofi logo

Sanofi·Phase 4·NCT00454272·197 enrolled

Show 2 more trials

Intracameral Antibiotic Safety Study

Suspended·PPanhandle Eye Group, LLP·Phase 3·NCT02590523·500 enrolled

IL-10 Stratifying Tool for Towards Antibiotic Selection for MRSaB

Completed·SSharp HealthCare·Phase 4·NCT02660346·40 enrolled

Cardiac Surgery4 trials

Prevention of Infections in Cardiac Surgery (PICS): a Cluster-randomized Factorial Cross-over Trial

Not yet recruiting·HHamilton Health Sciences Corporation·Phase 4·NCT06567808·38,000 enrolled

Efficacy of Diluted Betadine vs Antibiotic Installation Before Surgical Wound Closure in Prevention of Post Cardiac Surgery Wound Infection

Unknown status·—·Phase 4·NCT05276687·80 enrolled

Topical Use of Vancomycin in Reducing Sternal Wound Infection in Cardiac Surgery (SWI Trial)

Terminated·UUniversity of Alberta·Phase 2·NCT02374853·1,037 enrolled

Show 1 more trial

Prevention of Infections in Cardiac Surgery (PICS) Prevena Study

Completed·PPopulation Health Research Institute·Phase 4·NCT03402945·4,107 enrolled

Antibiotics4 trials

Early Antibiotics After Aspiration in ICU Patients

Terminated·UUConn Health·Phase 4·NCT05079620·5 enrolled

Responses to Rabies Vaccine in Adults With or Without Antibiotics

Completed·EEmory University·Phase 4·NCT03557008·37 enrolled

Study of Antibiotics in Cerebrospinal Fluid Following Intravenous Injection

Withdrawn·—·Phase 1·NCT00925093

Show 1 more trial

A Comparison of Fidaxomicin and Vancomycin in Patients With CDI Receiving Antibiotics for Concurrent Infections

Completed·UUniversity of Michigan·Phase 4·NCT02692651·144 enrolled

Staphylococcus Aureus4 trials

Staphylococcus Aureus Network Adaptive Platform Trial

Recruiting·UUniversity of Melbourne·Phase 4·NCT05137119·8,000 enrolled

Ceftobiprole in the Treatment of Resistant Staphylococcus Aureus Skin and Skin Structure Infections

Completed· Basilea Pharmaceutica logo

Basilea Pharmaceutica·Phase 3·NCT00228982·784 enrolled

A Phase 3 Telavancin Staphylococcus Aureus (S. Aureus) Bacteremia Trial

Terminated·CCumberland Pharmaceuticals·Phase 3·NCT02208063·121 enrolled

Show 1 more trial

Vancomycin Versus Daptomycin for the Treatment of Methicillin Resistant Staphylococcus Aureus (MRSA) Bacteremia

Terminated·SSingapore General Hospital·Phase 2·NCT01975662·14 enrolled

Clostridium Difficile4 trials

A Study of SMT19969 Compared With Vancomycin for the Treatment of Clostridium Difficile-Associated Diarrhoea (CDAD)

Completed·SSummit Therapeutics·Phase 2·NCT02092935·100 enrolled

Study of Nitazoxanide in the Treatment of Clostridium Difficile-associated Disease

Terminated·RRomark Laboratories L.C.·Phase 3·NCT00384527·50 enrolled

Oral Vancomycin for Preventing Clostridium Difficile Recurrence

Terminated·RRochester General Hospital·Phase 4·NCT03200093·65 enrolled

Show 1 more trial

TOX NEG Trial: Clostridium Difficile Diagnosis and Treatment

Completed·WWashington University School of Medicine·Phase 4·NCT03388268·15 enrolled

Ulcerative Colitis3 trials

A Phase 1b Trial to Evaluate the Safety of MB310 in Patients With Active, Mild-to-Moderate Ulcerative Colitis

Completed·MMicrobiotica Ltd·Phase 1·NCT06582264·29 enrolled

Antibiotics for the Treatment of Ulcerative Colitis

Completed·UUniversity of Dundee·N/A·NCT00355602·40 enrolled

Refined Fecal Microbiota Transplantation (FMT) for Ulcerative Colitis (UC)

Terminated·AAri M Grinspan·Phase 1·NCT04968951·4 enrolled

Sclerosing Cholangitis3 trials

Vancomycin in Primary Sclerosing Cholangitis in Italy

Recruiting·UUniversity of Milano Bicocca·Phase 2·NCT05876182·84 enrolled

Effect and Safety of Oral Vancomycin in Primary Sclerosing Cholangitis Patients

Unknown status·TTehran University of Medical Sciences·Phase 4·NCT02605213·30 enrolled

A Pilot Study to Characterize Bile Acid Metabolism and Dysbiosis in Primary Sclerosing Cholangitis

Completed·UUniversity of Minnesota·Phase 1·NCT02464020·8 enrolled

Surgical Site Infection3 trials

Intra-wound Vancomycin Powder for Prevention of Surgical Site Infection Following Spinal Surgery

Recruiting·RRabin Medical Center·Phase 3·NCT05959603·363 enrolled

The Effect of Intrawound Vancomycin Powder on Surgical Site Infection in Inguinal Lymph Node Dissection

Recruiting·WWomen and Infants Hospital of Rhode Island·Phase 2/3·NCT05625373·30 enrolled

Linezolid or Vancomycin Surgical Site Infection Prophylaxis

Recruiting·AAssistance Publique Hopitaux De Marseille·Phase 4·NCT05571722·1,160 enrolled

Infection3 trials

Clostridioides Difficile Controlled Human Infection Model

Not yet recruiting·LLeiden University Medical Center·N/A·NCT06702345·60 enrolled

TNP-2092 to Treat Acute Bacterial Skin and Skin Structure Infection

Completed·TTenNor Therapeutics Limited·Phase 2·NCT03964493·120 enrolled

TD-1792 in Gram-positive Complicated Skin and Skin Structure Infection

Completed·TTheravance Biopharma·Phase 2·NCT00442832·203 enrolled

Neutropenia3 trials

Daptomycin or Vancomycin in Treating Bacteria in the Blood in Patients With Neutropenia Caused By Chemotherapy

Withdrawn·WWake Forest University Health Sciences·N/A·NCT00296049

Meropenem Versus Meropenem Plus Glycopeptide in Patients With Febrile Neutropenia After Allogenic Blood Stem Cell Transplantation

Completed·PPETHEMA Foundation··NCT00462878·392 enrolled

Early Versus Late Stopping of Antibiotics in Children With Cancer and High-risk Febrile Neutropenia

Completed·MMurdoch Childrens Research Institute·Phase 4·NCT04948463·55 enrolled

Infective Endocarditis2 trials

Vancomycin, Gentamycin in Infective Endocarditis

Unknown status·—·N/A·NCT03688659·30 enrolled

Fosfomycin Plus Imipenem for Treatment of Infective Endocarditis

Completed·JJuan A. Arnaiz·Phase 4·NCT00871104·50 enrolled

Open Fracture2 trials

Local Application of Vancomycin Powder in Grade I-IIIA Open Fractures

Terminated·UUniversity of Tennessee·Phase 4·NCT02400112·11 enrolled

Acute Application of Antibiotic Powder in Open Fracture Wounds

Completed·UUniversity of Colorado, Denver·Phase 4·NCT04872400·20 enrolled

Colitis2 trials

Fecal Microbiota Transplantation in Recurrent or Refractory Clostridium Difficile Colitis

Unknown status·UUniversity Hospital Tuebingen·N/A·NCT01942447·30 enrolled

Intracolonic Vancomycin Therapy in Severe C. Diff Colitis

Terminated·CCorewell Health East·N/A·NCT01346059·2 enrolled

Total Knee Arthroplasty2 trials

Effectiveness of Adding Morphine to Intraosseous Vancomycin for Pain Control in Total Knee Arthroplasty

Completed·CCarilion Clinic·Phase 2·NCT06716749·100 enrolled

A Prospective, Randomized Parallel Group Study of the Efficacy of Vancomycin Administered Through Intraarticular Injection Versus Intraosseous Injection Versus Intravenous Infusion in Patients Undergoing Total Knee Arthroplasty

Recruiting·UUniversity of California, San Diego·Phase 4·NCT07282782·30 enrolled

Surgical Site Infections2 trials

Delafloxacin IV and OS Administration Compared to Best Available Therapy in Patients With Surgical Site Infections

Terminated· Menarini logo

Menarini·Phase 3·NCT04042077·268 enrolled

Checklist to Prevent MRSA Surgical Site Infections

Completed·VVA Office of Research and Development·N/A·NCT02216227·1,794 enrolled

Clostridioides difficile Infection2 trials

ACX-362E [Ibezapolstat] for Oral Treatment of Clostridioides Difficile Infection

Completed·AAcurx Pharmaceuticals Inc.·Phase 2·NCT04247542·53 enrolled

Lyophilized Fecal Microbiome Transfer vs. Vancomycin Monotherapy for Primary Clostridioides Difficile Infection

Recruiting·RRambam Health Care Campus·N/A·NCT05709184·196 enrolled

Diabetic Foot2 trials

Application of Daptomycin in MRSA Infected Diabetic Foot in Comparison to Vancomycin Treatment

Terminated·RRuhr University of Bochum·Phase 3·NCT01199783·1 enrolled

Outpatient Treatment of Gram Positive Wound Infections in the Diabetic Foot: A Pharmaco-economic Comparison of Daptomycin vs. Vancomycin Based Regimens

Terminated·CClinical Alliance for Research & Education - Infectious Diseases, LLC.·Phase 4·NCT01133600·6 enrolled

Acute Kidney Injury2 trials

Vancomycin-Associated Acute Kidney Injury: A Cross-Sectional Study From a Multi- Center in China

Unknown status·PPeking University First Hospital··NCT03456544·10,000 enrolled

A Pragmatic Clinical Trial Comparing the Risk of Acute Kidney Injury During Treatment With Vancomycin and Piperacillin-Tazobactam vs. Vancomycin and Cefepime in Hospitalized Patients

Recruiting·UUniversity of Pennsylvania·Phase 4·NCT06954129·750 enrolled

Prevention2 trials

Prevention of Infection in Closed Fractures: Cefazolin Versus Vancomycin

Terminated·UUniversity of Tennessee·N/A·NCT02027532·430 enrolled

Oral Vancomycin Vs Placebo in the Prevention of Recurrence of Clostridioides Difficile's Infection

Completed·JJulia Orígüen·Phase 3·NCT05320068·24 enrolled

Gut Microbiome2 trials

Effect of Antibiotics on Gut Microbiome and Plasma Metabolome

Completed·FFinnish Institute for Health and Welfare·Phase 4·NCT03273296·39 enrolled

The Effect of an Antibiotic on the Production of Uremic Toxins by the Gut Microbiome

Completed·NNYU Langone Health·Phase 2·NCT03452189·15 enrolled

Intravenous Administration2 trials

Evaluating the Use of Large-dose, Extended Interval Vancomycin Intravenous Administration for Skin and Soft Tissue Infections

Completed·FFraser Health·N/A·NCT01037192·4 enrolled

Vancomycin Tissue Concentrations by Bier Block or Intravenous Administration

Completed·MMayo Clinic·Phase 1·NCT04673877·20 enrolled

Adult1 trial

First-in-human Study of VE303 in Healthy Adult Volunteers

Completed·VVedanta Biosciences, Inc.·Phase 1·NCT04236778·39 enrolled

Hepatocellular Carcinoma1 trial

Vancomycin in Patients With Unresectable Fibrolamellar Hepatocellular Carcinoma (FLC) Oral

Withdrawn·NNational Cancer Institute (NCI)·Phase 2·NCT04025567

Cancer1 trial

Comparative Study of Ceftazidime-Avibactam Versus Standard of Care as Therapy in Febrile Neutropenic Adults With Cancer

Terminated·FForest Laboratories·Phase 2·NCT02732327·2 enrolled

Prospective1 trial

PHASE II SINGLE-CENTER, RANDOMIZED, OPEN-LABEL, PROSPECTIVE, STUDY TO DETERMINE THE IMPACT OF SERIAL PROCALCITONIN

Completed·MM.D. Anderson Cancer Center·Phase 2·NCT04983901·100 enrolled

Critically Ill Patients1 trial

Utility of Vancomycin Loading: A Pharmacokinetic Analysis in Critically Ill Patients

Terminated·MM.D. Anderson Cancer Center·N/A·NCT01157533·1 enrolled

Liver Transplant1 trial

Vancomycin Treatment in Recurrent PSC in Liver Transplant Patients

Withdrawn·OOchsner Health System·N/A·NCT03046901

Soft Tissue Infections1 trial

Efficacy and Safety of Daptomycin Versus Vancomycin or Teicoplanin for Treatment of Complicated Skin and Soft Tissue Infections

Terminated· Novartis logo

Novartis·Phase 3·NCT00430937·194 enrolled

Antibiotic Therapy1 trial

Optimized Antibiotic Therapy in Patients With Subarachnoid Haemorrhage (ES) and Cerebral Haemorrhage (EC)

Unknown status·AAzienda Sanitaria-Universitaria Integrata di Udine··NCT04132115·104 enrolled

Methicillin-Resistant Staphylococcus Aureus Infection1 trial

Cotrimoxazole Versus Vancomycin for Invasive Methicillin-resistant Staphylococcus Aureus Infections

Completed·RRabin Medical Center·Phase 3·NCT00427076·252 enrolled

Hematologic Cancer1 trial

Prevention of Infection in Patients With Hematologic Cancer and Persistent Fever Caused by a Low White Blood Cell Count

Completed·EEuropean Organisation for Research and Treatment of Cancer - EORTC·Phase 3·NCT00003805·859 enrolled

Preoperative1 trial

Preoperative Antibiotics for Carpal Tunnel Release Surgery

Completed·WWellSpan Health·Phase 4·NCT03432858·184 enrolled

Wound Infection1 trial

To Assess Use of Vancomycin Powder in Craniotomy on Wound Infection Rates

Unknown status·—·Phase 4·NCT04917627·500 enrolled

Effectiveness1 trial

The Effectiveness of Vancomycin in Comarison With Cefazolin in Prevention of SSI After Craniotomy

Unknown status·IIsfahan University of Medical Sciences·Phase 1/2·NCT03466645·126 enrolled

Peritonitis1 trial

Vancomycin Plus Moxifloxacin Versus Vancomycin Plus Ceftazidime for the Treatment of Peritoneal Dialysis (PD)-Related Peritonitis

Completed·PPeking University First Hospital·N/A·NCT02787057·80 enrolled

Adolescent1 trial

Safety, Tolerability and the Pharmacokinetics of Ridinilazole in Adolescent Subjects

Terminated·SSummit Therapeutics·Phase 3·NCT04802837·2 enrolled

Outcome1 trial

Clinical and Economic Outcomes of Ceftaroline Fosamil for ABSSSI Documented or at Risk of MRSA

Completed·WWayne State University·Phase 4·NCT02582203·174 enrolled

Autism Spectrum Disorder1 trial

Microbiota Transfer Therapy for Adults With Autism Spectrum Disorder (ASD) Who Have Gastrointestinal Disorders

Active, not recruiting·—·Phase 2·NCT03408886·55 enrolled

Rheumatoid Arthritis1 trial

Role of Oral and Intestinal Microbiota in Rheumatoid Arthritis (RA)

Completed·NNYU Langone Health·N/A·NCT01198509·178 enrolled

Fidaxomicin1 trial

Study to Assess Inhibition of Spore Production in Patients With C. Difficile Infections: Fidaxomicin Versus Vancomycin

Completed·HHartford Hospital·Phase 4·NCT01818141·34 enrolled

Concentration1 trial

Steady State Serum and Epithelial Lining Fluid (ELF) Antibiotics Concentrations Under Continous Infusion

Terminated·UUniversity Hospital Tuebingen··NCT00435305·40 enrolled

Hematopoietic Stem Cell Transplant1 trial

Prevention of C.Difficile Infections With Oral Vancomycine in Patients Undergoing Allogeneic Hematopoietic Stem Cell Transplant

Unknown status·AAssistance Publique - Hôpitaux de Paris·Phase 3·NCT05256693·336 enrolled

Endothelial Function1 trial

Effect of Probiotic Supplementation on Endothelial Function

Completed·MMedical College of Wisconsin·Phase 4·NCT01952834·21 enrolled

Osteoarticular Infections1 trial

Dalbavancin For The Treatment of Gram Positive Osteoarticular Infections

Completed·IInfectious Diseases Physicians, Inc.·Phase 4·NCT03426761·41 enrolled

Hospitalized Patients1 trial

Cost Study of Linezolid Versus Vancomycin Among Previously Hospitalized Patients

Completed· Pfizer logo

Pfizer··NCT01363271·7,260 enrolled

Mortality1 trial

Impact of Treatment With Colistin on Mortality Bacteremia Multiresistant Acinetobacter Baumannii Sensitive Colistin in Patients Critical

Completed·MMaimónides Biomedical Research Institute of Córdoba··NCT02573064·113 enrolled

Catheter Related Bloodstream Infection1 trial

Vancomycin Study: Treatment of Catheter Related Bloodstream Infection Caused by Coagulase Negative Staphylococcus

Completed·UUniversity of British Columbia·N/A·NCT00175370·60 enrolled

Cellulitis1 trial

Study Comparing CUBICIN® (Daptomycin for Injection) With Vancomycin in Cellulitis or Erysipelas

Completed· Merck & Co. logo

Merck & Co.·Phase 4·NCT00295178·80 enrolled

Renal Failure1 trial

Acute Renal Failure in the Surgical Intense Care Units - NTUH-SICU-ARF (NSARF) Study

Unknown status·NNational Taiwan University Hospital·N/A·NCT00451373·300 enrolled

Peritoneal Dialysis1 trial

Vancomycin Pharmacokinetics in Patients on Peritoneal Dialysis

Completed·TThomas Jefferson University·Phase 1·NCT03685747·4 enrolled

Clinical Trial1 trial

A Clinical Trial for Analysis of Intestinal Microbiome Affecting PK, PD, and Safety of Metformin

Completed·SSeoul National University Hospital·N/A·NCT03809260·20 enrolled

Non-Small Cell Lung Cancer1 trial

Safety Trial of Antimicrobial Therapy and Precision Radiation Therapy in Patients With Oligoprogressive Non-small Cell Lung Cancer

Recruiting·—·Phase 1·NCT03546829·10 enrolled

Total Knee Replacement1 trial

Regional Prophylactic Vancomycin in Revision Total Knee Replacement

Completed·MMayo Clinic·Phase 2/3·NCT02020031·22 enrolled

Chronic Rhinosinusitis1 trial

Topical Antibiotics in Chronic Rhinosinusitis

Completed·MMayo Clinic·Phase 1/2·NCT03673956·19 enrolled

Sepsis1 trial

Neonatal Suspected Sepsis Treated With Cefazolin or Vancomycin

Completed·HHospital Italiano de Buenos Aires·Phase 3·NCT01867138·109 enrolled

Charcot Foot Ulcer1 trial

Pulsed Electromagnetic Field Stimulation and Charcot Foot Ulcer

Recruiting·—·N/A·NCT06527131·34 enrolled

Microbiota1 trial

FMT for Moderate to Severe CDI: A Randomised Study With Concurrent Stool Microbiota Assessment

Unknown status·—·N/A·NCT02570477·30 enrolled

Toxicity1 trial

Safety and Efficacy of Strategy to Prevent Drug-Induced Nephrotoxicity in High-Risk Patients

Terminated·HHenry Ford Health System·Phase 4·NCT01734694·100 enrolled

Shoulder Arthroplasty1 trial

Daptomycin Use for Antimicrobial Prophylaxis in Methicillin Resistant Staphylococcus Aureus (MRSA) Colonized Adult Patients Undergoing Primary Elective Hip, Knee, or Shoulder Arthroplasty

Terminated·MMountain Home Research & Education Corporation·Phase 4·NCT01196169·28 enrolled

Prosthetic-joint Infection1 trial

Efficacy and Safety Study of Antibiotic Treatment to Treat Hip Prosthetic Joint Infection

Unknown status·UUniversity Hospital, Tours·Phase 2·NCT01757236·100 enrolled

Insulin Sensitivity1 trial

The Importance of the Gut Microbiota in Body Weight Control and Insulin Sensitivity

Completed·MMaastricht University Medical Center·N/A·NCT02241421·57 enrolled

Spine Surgery1 trial

The Effect of Intrawound Vancomycin Powder in Spine Surgery

Recruiting·WWindsor-Essex Compassionate Care Community·Phase 4·NCT04825522·1,643 enrolled

Crohn's Disease1 trial

Pilot Study of Fundamental Modification of the Gut Microbiota in the Treatment of Refractory Crohn's Disease

Completed·—·Phase 2·NCT03476317·10 enrolled

Randomized1 trial

Vancomycin Dosing for Serious MRSA Infections: A Non-inferiority Randomized Trial of Trough Level Versus AUC/MIC

Recruiting·AAnthony Bai·N/A·NCT04793152·700 enrolled

Surgical Wound Infection1 trial

Prevention of Neurosurgical Wound Infections

Completed·OOregon Health and Science University·N/A·NCT00915967·214 enrolled

Kidney Stone1 trial

A Randomized Trial of Preoperative Prophylactic Antibiotics Prior to Kidney Stone Surgery (Percutaneous Nephrolithotomy [PCNL])

Completed·UUniversity of California, San Diego·Phase 4·NCT02384200·86 enrolled

Renal Replacement Therapy1 trial

Safety and TDM of Continuous Infusion Vancomycin Through Continuous Renal Replacement Therapy Solution

Unknown status·—·Phase 1·NCT02663596·10 enrolled

Efficacy1 trial

Efficacy of Local Powder Prophylactics

Unknown status·—·N/A·NCT01372371·1,844 enrolled

Obesity1 trial

Vancomycin Dose Optimization in Obesity

Recruiting·UUniversity of Michigan·Phase 1·NCT06601257·24 enrolled

Staphylococcus Aureus Bacteremia1 trial

DOTS: Dalbavancin as an Option for Treatment of Staphylococcus Aureus Bacteremia

Completed·NNational Institute of Allergy and Infectious Diseases (NIAID)·Phase 2·NCT04775953·200 enrolled

Melanoma1 trial

A Phase 1b Trial to Evaluate Safety of MB097 in Combination With Pembrolizumab in Melanoma Patients

Active, not recruiting·MMicrobiotica Ltd·Phase 1·NCT06540391·41 enrolled

Treatment1 trial

Treatment of Neutropenic Patients With Fever Who Are Suspected to Have A Gram Positive Infection

Completed· Pfizer logo

Pfizer·Phase 3·NCT00035425·120 enrolled

Cystic Fibrosis1 trial

Pharmacokinetics of Vancomycin for Inhalation in Cystic Fibrosis

Withdrawn·—·Phase 1·NCT01509339

Critically Ill1 trial

Precision Dosing of Vancomycin in Critically Ill Children

Completed·UUniversity Hospital, Ghent·Phase 4·NCT04666948·314 enrolled

Bloodstream Infection1 trial

Linezolid in the Treatment of Hemodialysis Patients With Catheter-Related Gram-Positive Bloodstream Infections

Terminated· Pfizer logo

Pfizer·Phase 3·NCT00108433·61 enrolled

Total Ankle Arthroplasty1 trial

Intraosseous vs. Intravenous Vancomycin Administration in Total Ankle Arthroplasty

Recruiting·TThe Methodist Hospital Research Institute·Phase 4·NCT06384651·40 enrolled

Oncology Patients1 trial

Vancomycin for C Difficile NAAT+/EIA- Hematology Oncology Patients

Completed·MMedical College of Wisconsin·Phase 2·NCT03030248·9 enrolled

Liver Cancer1 trial

Fecal Microbiota Transfer in Liver Cancer to Overcome Resistance to Atezolizumab/Bevacizumab (FLORA)

Recruiting·MMichael Dill·Phase 2·NCT05690048·48 enrolled

Encephalopathy1 trial

VE303 for Treatment of Hepatic Encephalopathy (HE)

Completed·PPatricia Bloom·Phase 2·NCT04899115·19 enrolled

Open Heart Surgery1 trial

The Effects of Gut Micribiota Disruption on the Immune Response After Open Heart Surgery

Unknown status·RRadboud University Medical Center·N/A·NCT03939273·80 enrolled

Probiotic Intervention1 trial

Maternal Probiotic Intervention to Improve Gut Health-Trial II-Pakistan

Recruiting·—·Phase 2·NCT07207434·144 enrolled

Regulatory

FDA Approval Timeline[5]

Apr 15, 1986

VANCOCIN HYDROCHLORIDE

NDA NDA050606

Jun 5, 1986

VANCOCIN HYDROCHLORIDE

NDA NDA050606

Oct 8, 1986

VANCOCIN HYDROCHLORIDE

NDA NDA050606

Aug 12, 1987

VANCOCIN HYDROCHLORIDE

NDA NDA050606

Aug 18, 1987

VANCOCIN HYDROCHLORIDE

NDA NDA050606

May 23, 1988

VANCOCIN HYDROCHLORIDE

NDA NDA050606

Jun 30, 1993

VANCOCIN HYDROCHLORIDE

NDA NDA050606

Sep 27, 1995

VANCOCIN HYDROCHLORIDE

NDA NDA050606

Jun 14, 1996

VANCOCIN HYDROCHLORIDE

NDA NDA050606

Jun 14, 1996

VANCOCIN HYDROCHLORIDE

NDA NDA050606

May 12, 1997

VANCOCIN HYDROCHLORIDE

NDA NDA050606

Mar 18, 1998

VANCOCIN HYDROCHLORIDE

NDA NDA050606

Mar 1, 1999

VANCOMYCIN HYDROCHLORIDE IN PLASTIC CONTAINER

NDA NDA050671

Feb 6, 2001

VANCOCIN HYDROCHLORIDE

NDA NDA050606

May 24, 2002

VANCOCIN HYDROCHLORIDE

NDA NDA050606

May 28, 2002

VANCOCIN HYDROCHLORIDE

NDA NDA050606

Mar 17, 2004

VANCOCIN HYDROCHLORIDE

NDA NDA050606

May 27, 2004

VANCOCIN HYDROCHLORIDE

NDA NDA050606

Jan 8, 2010

VANCOCIN HYDROCHLORIDE

NDA NDA050606

Dec 14, 2011

VANCOCIN HYDROCHLORIDE

NDA NDA050606

Jan 26, 2018

FIRVANQ KIT

NDA NDA208910

Jul 10, 2018

VANCOMYCIN HYDROCHLORIDE

NDA NDA209481

Feb 15, 2019

TYZAVAN

NDA NDA211962

Aug 11, 2020

VANCOCIN HYDROCHLORIDE

NDA NDA050606

Jan 29, 2021

VANCOCIN HYDROCHLORIDE

NDA NDA050606

Aug 26, 2021

VANCOMYCIN

NDA NDA213895

Dec 22, 2021

VANCOCIN HYDROCHLORIDE

NDA NDA050606

Jan 20, 2023

VANCOMYCIN HYDROCHLORIDE

NDA NDA210274

Sources

References

[1]
ClinicalTrials.gov — 277 trial records for Vancomycin. U.S. National Library of Medicine, National Institutes of Health.
[2]
MedlinePlus Drug Information — Vancocin drug information. U.S. National Library of Medicine, National Institutes of Health.
[3]
ChEMBL — Vancomycin compound record. European Bioinformatics Institute (EMBL-EBI).
[4]
Open Targets Platform — Drug–disease associations for Vancomycin. EMBL-EBI & Wellcome Sanger Institute.
[5]
OpenFDA — FDA approval records (NDA NDA210274). U.S. Food & Drug Administration.
[6]
FDA Orange Book — Patent and exclusivity data for Vancocin. U.S. Food & Drug Administration.
[7]
SEC EDGAR — Hikma Pharmaceuticals LLC company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[3]
Highest Phase: Approved[1]
Company: HHikma Pharmaceuticals LLC

Patent Landscape[6]

Patent Cliff

Mar 13, 2035

Earliest patent expiration — generic entry possible after this date

Patent #Expires

10959946Mar 13, 2035

10959947Mar 13, 2035

10959948Mar 13, 2035

10959949Mar 13, 2035

11638692Mar 13, 2035

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