Vancocin

(Vancomycin)

ApprovedSmall molecule

Vancomycin is an antibiotic used to treat serious bacterial infections, particularly those caused by bacteria that are resistant to other common antibiotics like methicillin-resistant Staphylococcus aureus (MRSA).[2] Vancocin is currently approved and in use across 70 indications[4].[1]

Vancocin is one of 886 small molecule programs targeting Clostridium Difficile Infection. It is currently in Approved.

Indications

275

Total Trials

Active Trials

885

Competitors

FDA Applications

NDA/BLA/ANDA regulatory filings

Patents

Pipeline

Status by Indication[4][1]

Indication

Clostridium Difficile InfectionCompleted

Respiratory Tract Infectious DisorderActive, not recruiting

Bacterial DiseaseActive, not recruiting

ArthropathyApproved

Metastatic MelanomaApproved

Subarachnoid HemorrhageActive, not recruiting

Staphylococcal Skin InfectionsActive, not recruiting

Revision of Total Knee ArthroplastyActive, not recruiting

AntibioticsTerminated

Open FractureTerminated

Clostridium Difficile InfectionApproved

Completed

Respiratory Tract Infectious DisorderApproved

Active, not recruiting

Bacterial DiseaseApproved

Active, not recruiting

ArthropathyApproved

Approved

Metastatic MelanomaApproved

Approved

Subarachnoid HemorrhagePreclinical

Active, not recruiting

Staphylococcal Skin InfectionsPreclinical

Active, not recruiting

Revision of Total Knee ArthroplastyPreclinical

Active, not recruiting

AntibioticsApproved

Terminated

Open FractureApproved

Terminated

Showing 10 of 67 indications

Competition

Competitive Landscape

449 competitors in Non-Small Cell Lung Cancer

#DrugCompanyPhaseTrials

Vancocin

HHikma Pharmaceuticals LLC

Approved

1 2

Tuoyi

SSun Yat-sen University

Phase 3

8 3

Pyrotinib

HHengrui Therapeutics, Inc.

Phase 3

3 4

JMT101

CCSPC Megalith Biopharmaceutical Co.,Ltd.

Phase 3

6 5

Remeron

OOrganon and Co

Preclinical

1 6

Treatment

GSK

Preclinical

1 7

Valemetostat Tosylate

Daiichi Sankyo

Preclinical

1 8

Aqupla

Jiangsu Simcere Pharmaceutical Co., Ltd.

Preclinical

—9

Ftorafur

TThe First Affiliated Hospital with Nanjing Medical University

Preclinical

—10

Vibramycin

PPfizer's Upjohn has merged with Mylan to form Viatris Inc.

Preclinical

—

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q4 2026

Phase 1Recruiting

Heart Failure

NCT07490054

Phase 3Recruiting

Surgical Site Infection

NCT05959603

Phase 2Recruiting

Probiotic Intervention

NCT07207434

Phase 2/3Recruiting

Clostridioides Difficile Infection

NCT07221370

N/ANot yet recruiting

Infection

NCT06702345

Q1 2027

Phase 2Not yet recruiting

Intraoperative

NCT07201987

Clinical

Trials by Indication[1]

Vancomycin19 trials

IO Vancomycin Spine

Not yet recruiting·TThe Methodist Hospital Research Institute·Phase 2/3·NCT06748144·30 enrolled

First Time Right of Vancomycin

Not yet recruiting·EErasmus Medical Center·N/A·NCT05964114·134 enrolled

Infection Rates Between Using of Vancomycin Versus Gentamycin in Primary ACLR

Unknown status·—··NCT06050785·110 enrolled

Show 16 more trials

IO vs IV Vancomycin in Tourniquetless TKA

Unknown status·TThe Methodist Hospital Research Institute·Phase 4·NCT05705843·40 enrolled

Vancomycin for the Treatment of NAAT(+)/Toxin(-) C. Difficile

Completed·MMedical College of Wisconsin·Phase 1·NCT03827447·7 enrolled

LocalVancomycinPowderToPreventPeriprostheticJointInfection.

Unknown status·—·Phase 2·NCT05697965·174 enrolled

Pharmacokinetics of Vancomycin in Adults Receiving ECMO

Completed·NNational Taiwan University Hospital·Phase 4·NCT00281281·24 enrolled

Phase 2 Study of Safety, Efficacy, and Pharmacokinetics of Higher Doses of Daptomycin and Vancomycin in MRSA Bacteremia

Terminated· Merck & Co. logo

Merck & Co.·Phase 2·NCT00695903·38 enrolled

The Influencing Factors of Vancomycin Trough Level and the Rate Achieving the Target Trough Level

Completed·SSoutheast University, China··NCT03806543·165 enrolled

A Phase 2a Study, Effect of Vancomycin With vs Without Delpazolid (LCB01-0371) in Patients With MRSA Bacteremia

Terminated·LLigaChem Biosciences, Inc.·Phase 2·NCT05225558·40 enrolled

Exploring Vancomycin Disposition in Neonates

Recruiting·UUniversitaire Ziekenhuizen KU Leuven·Phase 4·NCT02096536·120 enrolled

The Effects of Daptomycin and Cytokines Production in Comparison With Vancomycin

Completed·HHospital Universitario Evangelico de Curitiba·Phase 4·NCT01626560·20 enrolled

Vancomycin in the Target Site Treatment of Intracranial Infection

Unknown status·XXijing Hospital·Phase 4·NCT03585426·2 enrolled

Pharmacokinetics Vancomycin CVVHDF with OXiris Membrane

Recruiting·MMahidol University·N/A·NCT06543940·8 enrolled

Model-informed Precision Dosing of Vancomycin in Adults

Completed·UUniversity Hospital, Ghent·Phase 4·NCT05535075·155 enrolled

Vancomycin vs. Vancomycin Plus Gentamycin in Treatment of MRSA Infection

Completed·MMichael E. DeBakey VA Medical Center·Phase 4·NCT00304811·160 enrolled

Oral Vancomycin Followed by Fecal Transplant Versus Tapering Oral Vancomycin

Terminated·UUniversity Health Network, Toronto·Phase 2/3·NCT01226992·81 enrolled

Neonatal Vancomycin Trial

Terminated·PPENTA Foundation·Phase 2·NCT02790996·242 enrolled

Loading Vancomycin Doses in the Emergency Department

Completed·CChristiana Care Health Services·N/A·NCT01162733·99 enrolled

Clostridium Difficile Infection17 trials

Screening to Prophylax Against Clostridium Difficile Infection -

Completed·CCorewell Health East·Phase 4·NCT02996487·1,294 enrolled

Fecal Microbiota Transplantation for Severe Clostridium Difficile Infection

Completed·—·Phase 2·NCT03427229·58 enrolled

Oral Vancomycin for Secondary Prophylaxis of Clostridium Difficile Infection (CDI)

Terminated·UUniversity of South Florida·Phase 4·NCT04000555·26 enrolled

Show 14 more trials

Oral Vancomyin for Primary Clostridium Difficile Infection Prophylaxis in Patients Receiving High-Risk Antibiotics

Completed·SSt. Luke's Hospital, Chesterfield, Missouri·Phase 4·NCT02951702·51 enrolled

Safety and Efficacy of Multiple Daily Dosing of Oral LFF571 in Patients With Moderate Clostridium Difficile Infections

Completed· Novartis logo

Novartis·Phase 2·NCT01232595·109 enrolled

Bezlotoxumab (BEZLO) In Addition To Standard Of Care (SOC) Vancomycin For The Treatment of Multi-Recurrent Clostridium Difficile Infection

Completed·UUniversity of Kansas Medical Center·Phase 4·NCT03880539·4 enrolled

A Phase IIIB/IV Study to Compare the Efficacy of Vancomycin Therapy to Extended Duration of Fidaxomicin Therapy in the Clinical Cure of Clostridium Difficile Infection (CDI) in an Older Population

Completed· Astellas logo

Astellas·Phase 4·NCT02254967·364 enrolled

Rectal Bacteriotherapy, Fecal Microbiota Transplantation or Oral Vancomycin Treatment of Recurrent Clostridium Difficile Infections

Unknown status·HHvidovre University Hospital·Phase 3·NCT02774382·450 enrolled

Oral Vancomycin Versus Probiotics Versus Placebo for Prevention of Clostridium Difficile Infection in Colonized Patients

Withdrawn·HHamilton Health Sciences Corporation·Phase 1·NCT04246151

Comparison of Ridinilazole Versus Vancomycin Treatment for Clostridium Difficile Infection

Completed·SSummit Therapeutics·Phase 3·NCT03595553·759 enrolled

Fecal Microbiota Transplantation for Relapsing Clostridium Difficile Infection

Completed·UUniversity of Aarhus·Phase 3·NCT02743234·64 enrolled

Vancomycin Prophylaxis in Recurrent Clostridium Difficile Infection

Unknown status·CCorewell Health West·Phase 4·NCT02237859·140 enrolled

MET-2 Clinical Study for Recurrent Clostridium Difficile Infection (CDI)

Completed·NNuBiyota·Phase 1·NCT02865616·19 enrolled

Initial Vancomycin Taper for the Prevention of Recurrent Clostridium Difficile Infection

Completed·MMcGill University Health Centre/Research Institute of the McGill University Health Centre·Phase 3·NCT04138706·263 enrolled

Fecal Microbiota Therapy for Recurrent Clostridium Difficile Infection

Unknown status·QQueen Elizabeth II Health Sciences Centre·Phase 2/3·NCT02686645·50 enrolled

Fecal Transplantation for Primary Clostridium Difficile Infection

Terminated·OOslo University Hospital·Phase 3·NCT03796650·104 enrolled

A Post-marketing, Blinded Study to Investigate How Effective Fidaxomicin is Compared to Vancomycin in the Sustained Cure of Clostridium Difficile Infection in Adults That Are Receiving Therapy to Suppress the Immune System

Terminated· Astellas logo

Astellas·Phase 4·NCT01775397·12 enrolled

Antibiotics11 trials

Topical Antibiotics in Surgical Site

Completed·UUniversidad Autonoma de Nuevo Leon·N/A·NCT05363462·75 enrolled

Evaluate the Effects of the Environmental Change in Intestine by Antibiotics on the Pharmacokinetic Characteristics of Simvastatin in Healthy Male Volunteers

Completed·SSeoul National University Hospital·Phase 1·NCT03403972·6 enrolled

Combination Study of Antibiotics With Enzalutamide (PROMIZE)

Recruiting·IInstitute of Cancer Research, United Kingdom·Phase 1/2·NCT06126731·39 enrolled

Show 8 more trials

Oral Vancomycin to Prevent Recurrent C Difficile Infection With Antibiotics

Completed·—·Phase 4·NCT03466502·104 enrolled

Systems Biology of Flu Vaccine in Healthy Adults With and Without the Use of Antibiotics

Completed·EEmory University·N/A·NCT02154061·33 enrolled

Antibiotics Continuous Infusion at Home

Unknown status·OOspedale San Carlo Borromeo·Phase 1·NCT04816968·50 enrolled

Early Antibiotics After Aspiration in ICU Patients

Terminated·UUConn Health·Phase 4·NCT05079620·5 enrolled

Study of Antibiotics in Cerebrospinal Fluid Following Intravenous Injection

Withdrawn·—·Phase 1·NCT00925093

A Comparison of Fidaxomicin and Vancomycin in Patients With CDI Receiving Antibiotics for Concurrent Infections

Completed·UUniversity of Michigan·Phase 4·NCT02692651·144 enrolled

Surgical Infection Rates With Adjunct Vancomycin Compared to Standard Peri-Operative IV Antibiotics

Unknown status·CCorewell Health West·N/A·NCT02299882·700 enrolled

Responses to Rabies Vaccine in Adults With or Without Antibiotics

Completed·EEmory University·Phase 4·NCT03557008·37 enrolled

Diarrhea9 trials

A Study to Compare Safety and Efficacy of OPT-80(Fidaxomicin) With Vancomycin in Subjects With Clostridium Difficile-associated Diarrhea (CDAD)

Completed· Astellas logo

Astellas·Phase 3·NCT02179658·210 enrolled

Comparison of Cadazolid Versus Vancomycin in Children With Clostridium Difficile-associated Diarrhea (CDAD)

Terminated· Johnson & Johnson logo

Johnson & Johnson·Phase 2/3·NCT03105479·1 enrolled

A Study to Investigate the Safety and Efficacy of Fidaxomicin (Oral Suspension or Tablets) and Vancomycin (Oral Liquid or Capsules) in Pediatric Subjects With Clostridium Difficile-associated Diarrhea (CDAD)

Completed· Astellas logo

Astellas·Phase 3·NCT02218372·148 enrolled

Show 6 more trials

Transplantation of Cultured Gut Microflora to Repeat Antibiotic-induced Diarrhea Due to Clostridium Difficile

Completed·PPer Hellström·Phase 2·NCT02857582·60 enrolled

Fidaxomicin Versus Vancomycin for the Treatment of Clostridium Difficile-Associated Diarrhea (CDAD) (MK-5119-018)

Completed· Merck & Co. logo

Merck & Co.·Phase 3·NCT00314951·629 enrolled

A Trial to Compare Xifaxan to Vancomycin for the Treatment of Clostridium Difficile-Associated Diarrhea (CDAD)

Completed·BBausch Health Americas, Inc.·Phase 3·NCT00269399·237 enrolled

A Study of CB-183,315 in Participants With Clostridium Difficile Associated Diarrhea (MK-4261-006)

Completed· Merck & Co. logo

Merck & Co.·Phase 3·NCT01598311·608 enrolled

Efficacy and Safety of Cadazolid Versus Vancomycin in Subjects With Clostridium Difficile - Associated Diarrhea

Completed· Johnson & Johnson logo

Johnson & Johnson·Phase 3·NCT01987895·632 enrolled

Study of CB-183,315 in Participants With Clostridium Difficile Associated Diarrhea (MK-4261-005)

Completed· Merck & Co. logo

Merck & Co.·Phase 3·NCT01597505·606 enrolled

Sclerosing Cholangitis6 trials

Investigation of Vancomycin Efficacy in Patients With Ulcerative Colitis and Primary Sclerosing Cholangitis

Not yet recruiting·MMcMaster University·Phase 2·NCT07341282·14 enrolled

Treating Primary Sclerosing Cholangitis and Biliary Atresia With Vancomycin

Recruiting·SSacramento Pediatric Gastroenterology·Phase 1·NCT02137668·200 enrolled

Primary Sclerosing Cholangitis With Oral Vancomycin by the Study of Its Antimicrobial and Immunomodulating Effects

Completed·SStanford University·Phase 3·NCT01802073·34 enrolled

Show 3 more trials

A Pilot Study of Vancomycin or Metronidazole in Patients With Primary Sclerosing Cholangitis

Completed·MMayo Clinic·Phase 1·NCT01085760·35 enrolled

Vancomycin in Primary Sclerosing Cholangitis in Italy

Recruiting·UUniversity of Milano Bicocca·Phase 2·NCT05876182·84 enrolled

Effect and Safety of Oral Vancomycin in Primary Sclerosing Cholangitis Patients

Unknown status·TTehran University of Medical Sciences·Phase 4·NCT02605213·30 enrolled

86 more indications

Infections6 trials

Delafloxacin vs Vancomycin and Aztreonam for the Treatment of Acute Bacterial Skin and Skin Structure Infections

Completed·MMelinta Therapeutics, Inc.·Phase 3·NCT01984684·850 enrolled

Intestinal Lavage for the Treatment of Severe C. Difficile Infections

Unknown status·LLondon Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's·Phase 2/3·NCT02466698·20 enrolled

Study Comparing Cubicin With Vancomycin in Treatment of Participants With Complicated Skin and Skin Structure Infections in a Home Infusion Setting

Terminated· Merck & Co. logo

Merck & Co.·Phase 4·NCT01175707·80 enrolled

Show 3 more trials

Evaluation of Daptomycin for the Emergency Department Treatment of Complicated Skin and Skin Structure Infections

Completed·UUniversity of Cincinnati·Phase 4·NCT01549613·104 enrolled

Dalbavancin for the Treatment of Acute Bacterial Skin and Skin Structure Infections in Children, Known or Suspected to be Caused by Susceptible Gram-positive Organisms, Including MRSA

Completed· AbbVie logo

AbbVie·Phase 3·NCT02814916·199 enrolled

Antibiotic Treatment for Infections of Short Term In-dwelling Vascular Catheters Due to Gram Positive Bacteria

Completed· Pfizer logo

Pfizer·Phase 3·NCT00037050·739 enrolled

Pneumonia6 trials

Aerosolized Vancomycin in Methicillin-Resistant Staphylococcus Aureus Pneumonia Under Mechanical Ventilation

Completed·SSeoul National University Hospital·Phase 2·NCT01925066·20 enrolled

Evaluation of Patients With Methicillin-Resistant Staphylococcus Aureus Hospital-Acquired Pneumonia Treated With Linezolid or Vancomycin

Completed· Pfizer logo

Pfizer··NCT01561469·188 enrolled

Nosocomial Pneumonia With Suspected Or Proven Methicillin-Resistant Staphylococcus Aureus (MRSA)

Completed· Pfizer logo

Pfizer·Phase 4·NCT00084266·1,225 enrolled

Show 3 more trials

Clinical Outcomes of Methicillin Resistant Staphylococcus Aureus (MRSA) Hospital-Based Pneumonia

Completed· Pfizer logo

Pfizer··NCT01819935·5,271 enrolled

Clinical Efficacy of Intravenous Iclaprim Versus Vancomycin in the Treatment of Hospital-Acquired, Ventilator-Associated, or Health-Care-Associated Pneumonia

Terminated·AArpida AG·Phase 2·NCT00543608·135 enrolled

Comparison of Telavancin and Vancomycin for Hospital-acquired Pneumonia Due to Methicillin-resistant Staphylococcus Aureus

Completed·CCumberland Pharmaceuticals·Phase 3·NCT00107952·761 enrolled

Skin Infection5 trials

Study of Debio 1450 for Bacterial Skin Infections

Completed·DDebiopharm International SA·Phase 2·NCT02426918·330 enrolled

Evaluation of Ceftaroline Fosamil Versus Vancomycin Plus Aztreonam in the Treatment of Patients With Skin Infections

Completed· Pfizer logo

Pfizer·Phase 3·NCT01499277·802 enrolled

China Registration Study in Patients With Skin Infections

Completed· AstraZeneca logo

AstraZeneca·Phase 3·NCT00772447·265 enrolled

Show 2 more trials

A Study to Assess Objective Endpoint Measurements of Response in Bacterial Skin Infections

Completed·MMelinta Therapeutics, Inc.·Phase 2·NCT01283581·256 enrolled

Daptomycin Versus Vancomycin in Participants With Skin Infections Due to MRSA

Completed· Merck & Co. logo

Merck & Co.·Phase 4·NCT01419184·250 enrolled

Cardiac Surgery5 trials

Prevention of Infections in Cardiac Surgery

Terminated·HHamilton Health Sciences Corporation·N/A·NCT02285140·5,989 enrolled

Prevention of Infections in Cardiac Surgery (PICS): a Cluster-randomized Factorial Cross-over Trial

Not yet recruiting·HHamilton Health Sciences Corporation·Phase 4·NCT06567808·38,000 enrolled

Efficacy of Diluted Betadine vs Antibiotic Installation Before Surgical Wound Closure in Prevention of Post Cardiac Surgery Wound Infection

Unknown status·—·Phase 4·NCT05276687·80 enrolled

Show 2 more trials

Prevention of Infections in Cardiac Surgery (PICS) Prevena Study

Completed·PPopulation Health Research Institute·Phase 4·NCT03402945·4,107 enrolled

Topical Use of Vancomycin in Reducing Sternal Wound Infection in Cardiac Surgery (SWI Trial)

Terminated·UUniversity of Alberta·Phase 2·NCT02374853·1,037 enrolled

Safety and Efficacy4 trials

Study of Daptomycin Safety and Efficacy for Complicated Skin and Skin Structure Infections (cSSSI) and Bacteremia in Renal Impairment

Terminated· Merck & Co. logo

Merck & Co.·Phase 4·NCT01104662·92 enrolled

Phase 3 Study to Evaluate Safety and Efficacy of Iclaprim Versus Vancomycin for ABSSSI: REVIVE-1

Completed·MMotif Bio·Phase 3·NCT02600611·600 enrolled

Phase 2 Safety and Efficacy Study of Daptomycin in Complicated Skin and Skin Structure Infections

Completed· Merck & Co. logo

Merck & Co.·Phase 2·NCT00426933·100 enrolled

Show 1 more trial

Phase 3 Study to Evaluate Safety and Efficacy of Iclaprim Versus Vancomycin for ABSSSI: REVIVE-2

Completed·MMotif Bio·Phase 3·NCT02607618·613 enrolled

Osteomyelitis4 trials

Safety and Efficacy Study of Daptomycin Compared to Active Comparator in Pediatric Participants With Acute Hematogenous Osteomyelitis (AHO) (MK-3009-006)

Completed· Merck & Co. logo

Merck & Co.·Phase 3·NCT01922011·149 enrolled

Vancomycin Or Trimethoprim/Sulfamethoxazole for Methicillin-resistant Staphylococcus Aureus Osteomyelitis

Completed·UUniversity of Washington·Phase 3·NCT00324922·2 enrolled

Study of Daptomycin in Subjects Undergoing Surgery for Osteomyelitis Associated With an Infected Prosthetic Caused by Staphylococci

Completed· Merck & Co. logo

Merck & Co.·Phase 2·NCT00428844·75 enrolled

Show 1 more trial

Prospective, Randomized, Multicenter Clinical Trial of Bisphosphonates Combined With Vancomycin for the Treatment of Cierny-Mader Type I and III Osteomyelitis

Not yet recruiting·SSecond Affiliated Hospital, School of Medicine, Zhejiang University·Phase 3·NCT07435051·280 enrolled

Surgical Site Infection4 trials

Linezolid or Vancomycin Surgical Site Infection Prophylaxis

Recruiting·AAssistance Publique Hopitaux De Marseille·Phase 4·NCT05571722·1,160 enrolled

Study for Antibiotic Impregnated Calcium Sulfate Beads as Prophylaxis for Surgical Site Infection

Unknown status·MMcMaster University·Phase 4·NCT03308253·60 enrolled

Intra-wound Vancomycin Powder for Prevention of Surgical Site Infection Following Spinal Surgery

Recruiting·RRabin Medical Center·Phase 3·NCT05959603·363 enrolled

Show 1 more trial

The Effect of Intrawound Vancomycin Powder on Surgical Site Infection in Inguinal Lymph Node Dissection

Recruiting·WWomen and Infants Hospital of Rhode Island·Phase 2/3·NCT05625373·30 enrolled

Ulcerative Colitis4 trials

VE202 in Patients With Mild-to-Moderate Ulcerative Colitis

Terminated·VVedanta Biosciences, Inc.·Phase 2·NCT05370885·114 enrolled

A Phase 1b Trial to Evaluate the Safety of MB310 in Patients With Active, Mild-to-Moderate Ulcerative Colitis

Completed·MMicrobiotica Ltd·Phase 1·NCT06582264·29 enrolled

Refined Fecal Microbiota Transplantation (FMT) for Ulcerative Colitis (UC)

Terminated·AAri M Grinspan·Phase 1·NCT04968951·4 enrolled

Show 1 more trial

Antibiotics for the Treatment of Ulcerative Colitis

Completed·UUniversity of Dundee·N/A·NCT00355602·40 enrolled

Clostridium Difficile3 trials

Oral Vancomycin for Preventing Clostridium Difficile Recurrence

Terminated·RRochester General Hospital·Phase 4·NCT03200093·65 enrolled

TOX NEG Trial: Clostridium Difficile Diagnosis and Treatment

Completed·WWashington University School of Medicine·Phase 4·NCT03388268·15 enrolled

A Study of SMT19969 Compared With Vancomycin for the Treatment of Clostridium Difficile-Associated Diarrhoea (CDAD)

Completed·SSummit Therapeutics·Phase 2·NCT02092935·100 enrolled

Probiotic Intervention3 trials

Maternal Probiotic Intervention to Improve Gut Health-Trial II-Pakistan

Recruiting·—·Phase 2·NCT07207434·144 enrolled

Maternal Probiotic Intervention to Improve Gut Health - Trial II - Burkina Faso (MPIGH-II)

Recruiting·UUniversity Ghent·Phase 2·NCT07134790·144 enrolled

Maternal Probiotic Intervention to Improve Gut Health - Trial II - Bangladesh

Enrolling by invitation·IInternational Centre for Diarrhoeal Disease Research, Bangladesh·Phase 2·NCT06817031·144 enrolled

Spine Surgery3 trials

Comparative Effectiveness and Cost-Benefit Analysis of Vancomycin Powder in High Risk Spine Surgery Patients

Withdrawn·VVanderbilt University Medical Center·N/A·NCT01566422

Vancomycin in Spine Surgery

Unknown status·UUniversity of Tennessee·Phase 4·NCT01977989·140 enrolled

The Effect of Intrawound Vancomycin Powder in Spine Surgery

Recruiting·WWindsor-Essex Compassionate Care Community·Phase 4·NCT04825522·1,643 enrolled

Neutropenia3 trials

Short vs Prolonged Antibiotic Treatment for Hospitalized Hemato-oncology Patients With Febrile Neutropenia

Unknown status·TTel-Aviv Sourasky Medical Center·Phase 4·NCT02463747·110 enrolled

Meropenem Versus Meropenem Plus Glycopeptide in Patients With Febrile Neutropenia After Allogenic Blood Stem Cell Transplantation

Completed·PPETHEMA Foundation··NCT00462878·392 enrolled

Daptomycin or Vancomycin in Treating Bacteria in the Blood in Patients With Neutropenia Caused By Chemotherapy

Withdrawn·WWake Forest University Health Sciences·N/A·NCT00296049

Antibiotic3 trials

Placement of Antibiotic Powder in Wounds During the Emergency Room

Recruiting·TThe University of Texas Health Science Center at San Antonio·Phase 4·NCT03765567·200 enrolled

Impact of Oral Antibiotic Treatment on C. Difficile

Completed·—·Phase 4·NCT02057198·33 enrolled

Intracameral Antibiotic Safety Study

Suspended·PPanhandle Eye Group, LLP·Phase 3·NCT02590523·500 enrolled

Infection3 trials

TD-1792 in Gram-positive Complicated Skin and Skin Structure Infection

Completed·TTheravance Biopharma·Phase 2·NCT00442832·203 enrolled

Clostridioides Difficile Controlled Human Infection Model

Not yet recruiting·LLeiden University Medical Center·N/A·NCT06702345·60 enrolled

TNP-2092 to Treat Acute Bacterial Skin and Skin Structure Infection

Completed·TTenNor Therapeutics Limited·Phase 2·NCT03964493·120 enrolled

Staphylococcus Aureus3 trials

Staphylococcus Aureus Network Adaptive Platform Trial

Recruiting·UUniversity of Melbourne·Phase 4·NCT05137119·8,000 enrolled

Ceftobiprole in the Treatment of Resistant Staphylococcus Aureus Skin and Skin Structure Infections

Completed· Basilea Pharmaceutica logo

Basilea Pharmaceutica·Phase 3·NCT00228982·784 enrolled

A Phase 3 Telavancin Staphylococcus Aureus (S. Aureus) Bacteremia Trial

Terminated·CCumberland Pharmaceuticals·Phase 3·NCT02208063·121 enrolled

Methicillin-resistant Staphylococcus Aureus2 trials

Vancomycin Versus Daptomycin for the Treatment of Methicillin-resistant Staphylococcus Aureus Bacteremia Due to Isolates With High Vancomycin Minimum Inhibitory Concentrations (MICs)

Terminated·SSt. John Health System, Michigan·Phase 4·NCT01287832·11 enrolled

Prevention of Gastrostomy-Related Wound Infection by Vancomycin in Carriers of Methicillin-Resistant Staphylococcus Aureus.

Unknown status·UUniversity Hospital, Geneva·Phase 2·NCT00150852·96 enrolled

Prevention2 trials

Oral Vancomycin Vs Placebo in the Prevention of Recurrence of Clostridioides Difficile's Infection

Completed·JJulia Orígüen·Phase 3·NCT05320068·24 enrolled

Prevention of Infection in Closed Fractures: Cefazolin Versus Vancomycin

Terminated·UUniversity of Tennessee·N/A·NCT02027532·430 enrolled

Fecal Microbiota Transplantation2 trials

Fecal Microbiota Transplantation by Colonoscopy for Recurrent C. Difficile Infection

Completed·—·Phase 2·NCT02148601·39 enrolled

Application of Fecal Microbiota Transplantation in Children With ASD

Unknown status·TTongji Hospital·Phase 1·NCT04948814·40 enrolled

Hepatocellular Carcinoma2 trials

Nivolumab (Anti-PD1), Tadalafil and Oral Vancomycin in People With Refractory Primary Hepatocellular Carcinoma or Liver Dominant Metastatic Cancer From Colorectal or Pancreatic Cancers

Terminated·NNational Cancer Institute (NCI)·Phase 2·NCT03785210·22 enrolled

Vancomycin in Patients With Unresectable Fibrolamellar Hepatocellular Carcinoma (FLC) Oral

Withdrawn·NNational Cancer Institute (NCI)·Phase 2·NCT04025567

Open Fracture2 trials

Powdered Intrawound Vancomycin in Open Fractures Trial

Not yet recruiting·UUniversity of Manitoba·Phase 4·NCT06504992·350 enrolled

Local Application of Vancomycin Powder in Grade I-IIIA Open Fractures

Terminated·UUniversity of Tennessee·Phase 4·NCT02400112·11 enrolled

Clostridioides difficile Infection2 trials

Enteral Vancomycin as Primary Prophylaxis Against Clostridioides Difficile Infection in Critically Ill Patients

Recruiting·RRiverside University Health System Medical Center·Phase 2/3·NCT07221370·176 enrolled

Lyophilized Fecal Microbiome Transfer vs. Vancomycin Monotherapy for Primary Clostridioides Difficile Infection

Recruiting·RRambam Health Care Campus·N/A·NCT05709184·196 enrolled

Crohn's Disease2 trials

Fundamental Modification of the Gut Microbiota in the Treatment of Refractory Crohn's Disease

Completed·UUniversity of Pennsylvania·Phase 2·NCT02765256·8 enrolled

Pilot Study of Fundamental Modification of the Gut Microbiota in the Treatment of Refractory Crohn's Disease

Completed·—·Phase 2·NCT03476317·10 enrolled

Critically Ill Patients2 trials

Utility of Vancomycin Loading: A Pharmacokinetic Analysis in Critically Ill Patients

Terminated·MM.D. Anderson Cancer Center·N/A·NCT01157533·1 enrolled

Cystatin-C C-guided Vancomycin Dosing in Critically Ill Patients: A Quality Improvement Project

Completed·MMayo Clinic·Phase 1·NCT02945241·399 enrolled

Bloodstream Infection1 trial

Linezolid in the Treatment of Hemodialysis Patients With Catheter-Related Gram-Positive Bloodstream Infections

Terminated· Pfizer logo

Pfizer·Phase 3·NCT00108433·61 enrolled

Intravenous Administration1 trial

Evaluating the Use of Large-dose, Extended Interval Vancomycin Intravenous Administration for Skin and Soft Tissue Infections

Completed·FFraser Health·N/A·NCT01037192·4 enrolled

Surgical Wound Infection1 trial

Prevention of Neurosurgical Wound Infections

Completed·OOregon Health and Science University·N/A·NCT00915967·214 enrolled

Critically Ill1 trial

Precision Dosing of Vancomycin in Critically Ill Children

Completed·UUniversity Hospital, Ghent·Phase 4·NCT04666948·314 enrolled

Total Ankle Arthroplasty1 trial

Intraosseous vs. Intravenous Vancomycin Administration in Total Ankle Arthroplasty

Recruiting·TThe Methodist Hospital Research Institute·Phase 4·NCT06384651·40 enrolled

Oncology Patients1 trial

Vancomycin for C Difficile NAAT+/EIA- Hematology Oncology Patients

Completed·MMedical College of Wisconsin·Phase 2·NCT03030248·9 enrolled

Liver Cancer1 trial

Fecal Microbiota Transfer in Liver Cancer to Overcome Resistance to Atezolizumab/Bevacizumab (FLORA)

Recruiting·MMichael Dill·Phase 2·NCT05690048·48 enrolled

Encephalopathy1 trial

VE303 for Treatment of Hepatic Encephalopathy (HE)

Completed·PPatricia Bloom·Phase 2·NCT04899115·19 enrolled

Open Heart Surgery1 trial

The Effects of Gut Micribiota Disruption on the Immune Response After Open Heart Surgery

Unknown status·RRadboud University Medical Center·N/A·NCT03939273·80 enrolled

Recurrent1 trial

Bezlotoxumab Versus FMT for Multiple Recurrent CDI

Withdrawn·LLeiden University Medical Center·Phase 4·NCT05077085

Infection Pro1 trial

Topical Vancomycin for Infection Prophylaxis in TJA

Not yet recruiting·AAlberta Hip and Knee Clinic·Phase 2·NCT04993027·100 enrolled

Metastatic Cancer1 trial

Study of VE800 and Nivolumab in Patients With Selected Types of Advanced or Metastatic Cancer

Completed·VVedanta Biosciences, Inc.·Phase 1/2·NCT04208958·56 enrolled

Intraoperative1 trial

Intraoperative Placement of Vancomycin-impregnated Calcium Sulfate Beads Conjugated With Analgesics to Improve Spine Surgery Outcomes

Not yet recruiting·GGanesh M. Shankar·Phase 2·NCT07201987·100 enrolled

Treatment1 trial

A Systems Biology Approach for Identification of Host and Microbial Mechanisms and Druggable Targets for the Treatment of PSC-IBD

Unknown status·UUniversity Hospital Birmingham NHS Foundation Trust··NCT05376228·15 enrolled

Autism1 trial

Beneficial Bacteria Treatment for Autism

Completed·—·Phase 1/2·NCT02504554·18 enrolled

Total Joint Arthroplasty1 trial

Vancomycin Powder and Dilute Povidone Iodine Lavage for Infection Prophylaxis in High Risk Total Joint Arthroplasty

Completed·NNYU Langone Health·Phase 1·NCT04075526·2,129 enrolled

Infection in Solid Organ Transplant Recipients1 trial

Fecal Microbiota Transplantation for C. Difficile Infection in Solid Organ Transplant Recipients

Terminated·UUniversity of Wisconsin, Madison·Phase 2·NCT03617445·3 enrolled

Efficacy and Safety1 trial

Evaluating the Efficacy and Safety of Intra-wound Vancomycin Powder in High Risk Patients

Recruiting·TThe University of Hong Kong·N/A·NCT03839914·76 enrolled

Inflammatory Bowel Disease1 trial

Use of Fidaxomicin Compared to Vancomycin for Decolonization of C. Difficile in Patients With Inflammatory Bowel Disease

Not yet recruiting·—·Phase 4·NCT06794944·60 enrolled

Gut Microbiota1 trial

Investigation of the Gut Microbiota in Regulating Nutrient Absorption in Humans

Completed·NNational Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)·Phase 2·NCT02037295·27 enrolled

Ventilator-Associated Pneumonia1 trial

Microbiologic Response With Linezolid And Vancomycin In Ventilator-Associated Pneumonia Due To Methicillin Resistant Staphylococcus Aureus

Completed· Pfizer logo

Pfizer·Phase 4·NCT00572559·149 enrolled

Metastatic Colorectal Cancer1 trial

Fecal Microbiota Transplant and Re-introduction of Anti-PD-1 Therapy (Pembrolizumab or Nivolumab) for the Treatment of Metastatic Colorectal Cancer in Anti-PD-1 Non-responders

Active, not recruiting·MM.D. Anderson Cancer Center·Phase 2·NCT04729322·15 enrolled

Total Knee Replacement1 trial

Regional Prophylactic Vancomycin With Restricted Tourniquet Time in Primary Total Knee Replacement

Completed·MMayo Clinic·Phase 2/3·NCT03506347·24 enrolled

Metabolic Syndrome1 trial

Interventional Bioremediation of Microbiota in Metabolic Syndrome

Terminated·UUniversity of Minnesota·Phase 2·NCT02730962·12 enrolled

Neurosurgery1 trial

Topical Vancomycin for Neurosurgery Wound Prophylaxis

Completed·—·Phase 3·NCT02284126·1,103 enrolled

Staphylococcus Aureus Bacteremia1 trial

Staphylococcus Aureus Bacteremia Antibiotic Treatment Options

Completed·HHeinrich-Heine University, Duesseldorf·Phase 3·NCT01792804·215 enrolled

Cirrhosis1 trial

Empirical vs 2nd Line Antibiotic Therapy in Health-care Associated Infections in Cirrhosis

Unknown status·UUniversity of Roma La Sapienza·Phase 4·NCT01820026·96 enrolled

Spinal Fusion1 trial

Intrawound Vancomycin Powder in Spinal Fusion Surgery

Completed·—·Phase 4·NCT02631408·308 enrolled

Immune Response1 trial

The Role of the Microbiota in the Systemic Immune Response

Completed·—·N/A·NCT02340182·12 enrolled

Multiple Sclerosis1 trial

Vancomycin Study in Multiple Sclerosis (MS)

Recruiting·IIcahn School of Medicine at Mount Sinai·Phase 1·NCT05539729·12 enrolled

Adult1 trial

First-in-human Study of VE303 in Healthy Adult Volunteers

Completed·VVedanta Biosciences, Inc.·Phase 1·NCT04236778·39 enrolled

Cancer1 trial

Comparative Study of Ceftazidime-Avibactam Versus Standard of Care as Therapy in Febrile Neutropenic Adults With Cancer

Terminated·FForest Laboratories·Phase 2·NCT02732327·2 enrolled

Prospective1 trial

PHASE II SINGLE-CENTER, RANDOMIZED, OPEN-LABEL, PROSPECTIVE, STUDY TO DETERMINE THE IMPACT OF SERIAL PROCALCITONIN

Completed·MM.D. Anderson Cancer Center·Phase 2·NCT04983901·100 enrolled

Outcome1 trial

Clinical and Economic Outcomes of Ceftaroline Fosamil for ABSSSI Documented or at Risk of MRSA

Completed·WWayne State University·Phase 4·NCT02582203·174 enrolled

Autism Spectrum Disorder1 trial

Microbiota Transfer Therapy for Adults With Autism Spectrum Disorder (ASD) Who Have Gastrointestinal Disorders

Active, not recruiting·—·Phase 2·NCT03408886·55 enrolled

Infective Endocarditis1 trial

Fosfomycin Plus Imipenem for Treatment of Infective Endocarditis

Completed·JJuan A. Arnaiz·Phase 4·NCT00871104·50 enrolled

Rheumatoid Arthritis1 trial

Role of Oral and Intestinal Microbiota in Rheumatoid Arthritis (RA)

Completed·NNYU Langone Health·N/A·NCT01198509·178 enrolled

Fidaxomicin1 trial

Study to Assess Inhibition of Spore Production in Patients With C. Difficile Infections: Fidaxomicin Versus Vancomycin

Completed·HHartford Hospital·Phase 4·NCT01818141·34 enrolled

Concentration1 trial

Steady State Serum and Epithelial Lining Fluid (ELF) Antibiotics Concentrations Under Continous Infusion

Terminated·UUniversity Hospital Tuebingen··NCT00435305·40 enrolled

Heart Failure1 trial

Intestinal Microbiota Transplantation in Patients With Chronic Heart Failure

Recruiting·MMelana Yuzefpolskaya, MD·Phase 1·NCT07490054·40 enrolled

Hematopoietic Stem Cell Transplant1 trial

Prevention of C.Difficile Infections With Oral Vancomycine in Patients Undergoing Allogeneic Hematopoietic Stem Cell Transplant

Unknown status·AAssistance Publique - Hôpitaux de Paris·Phase 3·NCT05256693·336 enrolled

Endothelial Function1 trial

Effect of Probiotic Supplementation on Endothelial Function

Completed·MMedical College of Wisconsin·Phase 4·NCT01952834·21 enrolled

Osteoarticular Infections1 trial

Dalbavancin For The Treatment of Gram Positive Osteoarticular Infections

Completed·IInfectious Diseases Physicians, Inc.·Phase 4·NCT03426761·41 enrolled

Prosthetic-joint Infection1 trial

Efficacy and Safety Study of Antibiotic Treatment to Treat Hip Prosthetic Joint Infection

Unknown status·UUniversity Hospital, Tours·Phase 2·NCT01757236·100 enrolled

Insulin Sensitivity1 trial

The Importance of the Gut Microbiota in Body Weight Control and Insulin Sensitivity

Completed·MMaastricht University Medical Center·N/A·NCT02241421·57 enrolled

Surgical Site Infections1 trial

Checklist to Prevent MRSA Surgical Site Infections

Completed·VVA Office of Research and Development·N/A·NCT02216227·1,794 enrolled

Total Knee Arthroplasty1 trial

A Prospective, Randomized Parallel Group Study of the Efficacy of Vancomycin Administered Through Intraarticular Injection Versus Intraosseous Injection Versus Intravenous Infusion in Patients Undergoing Total Knee Arthroplasty

Recruiting·UUniversity of California, San Diego·Phase 4·NCT07282782·30 enrolled

Gut Microbiome1 trial

Effect of Antibiotics on Gut Microbiome and Plasma Metabolome

Completed·FFinnish Institute for Health and Welfare·Phase 4·NCT03273296·39 enrolled

Randomized1 trial

Vancomycin Dosing for Serious MRSA Infections: A Non-inferiority Randomized Trial of Trough Level Versus AUC/MIC

Recruiting·AAnthony Bai·N/A·NCT04793152·700 enrolled

Acute Kidney Injury1 trial

Vancomycin-Associated Acute Kidney Injury: A Cross-Sectional Study From a Multi- Center in China

Unknown status·PPeking University First Hospital··NCT03456544·10,000 enrolled

Liver Transplant1 trial

Vancomycin Treatment in Recurrent PSC in Liver Transplant Patients

Withdrawn·OOchsner Health System·N/A·NCT03046901

Soft Tissue Infections1 trial

Efficacy and Safety of Daptomycin Versus Vancomycin or Teicoplanin for Treatment of Complicated Skin and Soft Tissue Infections

Terminated· Novartis logo

Novartis·Phase 3·NCT00430937·194 enrolled

Antibiotic Therapy1 trial

Optimized Antibiotic Therapy in Patients With Subarachnoid Haemorrhage (ES) and Cerebral Haemorrhage (EC)

Unknown status·AAzienda Sanitaria-Universitaria Integrata di Udine··NCT04132115·104 enrolled

Methicillin-Resistant Staphylococcus Aureus Infection1 trial

Cotrimoxazole Versus Vancomycin for Invasive Methicillin-resistant Staphylococcus Aureus Infections

Completed·RRabin Medical Center·Phase 3·NCT00427076·252 enrolled

Hematologic Cancer1 trial

Prevention of Infection in Patients With Hematologic Cancer and Persistent Fever Caused by a Low White Blood Cell Count

Completed·EEuropean Organisation for Research and Treatment of Cancer - EORTC·Phase 3·NCT00003805·859 enrolled

Wound Infection1 trial

To Assess Use of Vancomycin Powder in Craniotomy on Wound Infection Rates

Unknown status·—·Phase 4·NCT04917627·500 enrolled

Effectiveness1 trial

The Effectiveness of Vancomycin in Comarison With Cefazolin in Prevention of SSI After Craniotomy

Unknown status·IIsfahan University of Medical Sciences·Phase 1/2·NCT03466645·126 enrolled

Peritonitis1 trial

Vancomycin Plus Moxifloxacin Versus Vancomycin Plus Ceftazidime for the Treatment of Peritoneal Dialysis (PD)-Related Peritonitis

Completed·PPeking University First Hospital·N/A·NCT02787057·80 enrolled

Adolescent1 trial

Safety, Tolerability and the Pharmacokinetics of Ridinilazole in Adolescent Subjects

Terminated·SSummit Therapeutics·Phase 3·NCT04802837·2 enrolled

Chronic Rhinosinusitis1 trial

Topical Antibiotics in Chronic Rhinosinusitis

Completed·MMayo Clinic·Phase 1/2·NCT03673956·19 enrolled

Sepsis1 trial

Neonatal Suspected Sepsis Treated With Cefazolin or Vancomycin

Completed·HHospital Italiano de Buenos Aires·Phase 3·NCT01867138·109 enrolled

Diabetic Foot1 trial

Application of Daptomycin in MRSA Infected Diabetic Foot in Comparison to Vancomycin Treatment

Terminated·RRuhr University of Bochum·Phase 3·NCT01199783·1 enrolled

Unspecified1 trial

Clostridioides Difficile Colonisation

Unknown status·LLeiden University Medical Center·Phase 1·NCT05693077·70 enrolled

Regulatory

FDA Approval Timeline[5]

Apr 15, 1986

VANCOCIN HYDROCHLORIDE

NDA NDA050606

Mar 1, 1999

VANCOMYCIN HYDROCHLORIDE IN PLASTIC CONTAINER

NDA NDA050671

Jan 26, 2018

FIRVANQ KIT

NDA NDA208910

Jul 10, 2018

VANCOMYCIN HYDROCHLORIDE

NDA NDA209481

Feb 15, 2019

TYZAVAN

NDA NDA211962

Aug 26, 2021

VANCOMYCIN

NDA NDA213895

Jan 20, 2023

VANCOMYCIN HYDROCHLORIDE

NDA NDA210274

Sources

References

[1]
ClinicalTrials.gov — 275 trial records for Vancomycin. U.S. National Library of Medicine, National Institutes of Health.
[2]
MedlinePlus Drug Information — Vancocin drug information. U.S. National Library of Medicine, National Institutes of Health.
[3]
ChEMBL — Vancomycin compound record. European Bioinformatics Institute (EMBL-EBI).
[4]
Open Targets Platform — Drug–disease associations for Vancomycin. EMBL-EBI & Wellcome Sanger Institute.
[5]
OpenFDA — FDA approval records (NDA NDA210274). U.S. Food & Drug Administration.
[6]
FDA Orange Book — Patent and exclusivity data for Vancocin. U.S. Food & Drug Administration.
[7]
SEC EDGAR — Hikma Pharmaceuticals LLC company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[3]
Highest Phase: Approved[1]
Company: HHikma Pharmaceuticals LLC

Patent Landscape[6]

Patent Cliff

Mar 13, 2035

Earliest patent expiration — generic entry possible after this date

Patent #Expires

10959946Mar 13, 2035

10959947Mar 13, 2035

10959948Mar 13, 2035

10959949Mar 13, 2035

11638692Mar 13, 2035

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10849956Nov 6, 2035