Vancocin

(Vancomycin)

ApprovedSmall molecule

Vancomycin is an antibiotic used to treat serious bacterial infections, particularly those caused by bacteria that are resistant to other common antibiotics like methicillin-resistant Staphylococcus aureus (MRSA).[2] Vancocin is currently approved and in use across 72 indications[4].[1]

Vancocin is one of 1197 small molecule programs targeting Arthropathy. It is currently in Approved.

Indications

271

Total Trials

Active Trials

1,196

Competitors

FDA Applications

NDA/BLA/ANDA regulatory filings

Patents

Pipeline

Status by Indication[4][1]

Indication

ArthropathyApproved

CellulitisActive, not recruiting

Total Joint ArthroplastyActive, not recruiting

Revision of Total Knee ArthroplastyActive, not recruiting

Metabolic SyndromeActive, not recruiting

ColitisActive, not recruiting

Bacterial DiseaseActive, not recruiting

NeutropeniaActive, not recruiting

Liver TransplantActive, not recruiting

ToxicityActive, not recruiting

ArthropathyApproved

Approved

CellulitisApproved

Active, not recruiting

Total Joint ArthroplastyPhase 1

Active, not recruiting

Revision of Total Knee ArthroplastyPreclinical

Active, not recruiting

Metabolic SyndromePhase 2

Active, not recruiting

ColitisPreclinical

Active, not recruiting

Bacterial DiseaseApproved

Active, not recruiting

NeutropeniaPreclinical

Active, not recruiting

Liver TransplantPreclinical

Active, not recruiting

ToxicityApproved

Active, not recruiting

Showing 10 of 69 indications

Competition

Competitive Landscape

1774 competitors in Lymphoma

#DrugCompanyPhaseTrials

Vancocin

HHikma Pharmaceuticals LLC

Approved

271 2

Blenoxane

SSequus Pharmaceuticals

Preclinical

25 3

Tafasitamab

Incyte

Preclinical

7 4

Nuvigil

NNuvo Research GmbH

Preclinical

1 5

Emend

CCidara Therapeutics Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)

Preclinical

1 6

Kenalog

BBausch Health Americas, Inc.

Preclinical

1 7

Elitek

AAzienda U.S.L. 1 di Massa e Carrara

Preclinical

—8

Decadron

QQuince Therapeutics S.p.A.

Preclinical

—9

Rhg-CSF

CCSPC Baike (Shandong) Biopharmaceutical Co., Ltd.

Preclinical

3 10

Stem Cells

KKang Stem Biotech Co., Ltd.

Preclinical

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q3 2026

Phase 1Recruiting

Multiple Sclerosis

NCT05539729

N/ARecruiting

Spine Surgery

NCT06439953

Q4 2026

Phase 1Recruiting

Heart Failure

NCT07490054

Phase 3Recruiting

Surgical Site Infection

NCT05959603

N/ANot yet recruiting

Infection

NCT06702345

Q1 2027

Phase 2Active, not recruiting

Spinal Fusion

NCT04017468

Clinical

Trials by Indication[1]

Vancomycin20 trials

LocalVancomycinPowderToPreventPeriprostheticJointInfection.

Unknown status·—·Phase 2·NCT05697965·174 enrolled

Haemoglobin And Vancomycin Pharmacokinetics in the Cerebrospinal Fluid Following Subarachnoid Haemorrhage

Not yet recruiting·UUniversity Hospital Southampton NHS Foundation Trust·N/A·NCT06373640·14 enrolled

Pharmacokinetics of Vancomycin in Adults Receiving ECMO

Completed·NNational Taiwan University Hospital·Phase 4·NCT00281281·24 enrolled

Show 17 more trials

Phase 2 Study of Safety, Efficacy, and Pharmacokinetics of Higher Doses of Daptomycin and Vancomycin in MRSA Bacteremia

Terminated· Merck & Co. logo

Merck & Co.·Phase 2·NCT00695903·38 enrolled

The Influencing Factors of Vancomycin Trough Level and the Rate Achieving the Target Trough Level

Completed·SSoutheast University, China··NCT03806543·165 enrolled

Vancomycin vs. Vancomycin Plus Gentamycin in Treatment of MRSA Infection

Completed·MMichael E. DeBakey VA Medical Center·Phase 4·NCT00304811·160 enrolled

Oral Vancomycin Followed by Fecal Transplant Versus Tapering Oral Vancomycin

Terminated·UUniversity Health Network, Toronto·Phase 2/3·NCT01226992·81 enrolled

Exploring Vancomycin Disposition in Neonates

Recruiting·UUniversitaire Ziekenhuizen KU Leuven·Phase 4·NCT02096536·120 enrolled

The Effects of Daptomycin and Cytokines Production in Comparison With Vancomycin

Completed·HHospital Universitario Evangelico de Curitiba·Phase 4·NCT01626560·20 enrolled

Model-informed Precision Dosing of Vancomycin in Adults

Completed·UUniversity Hospital, Ghent·Phase 4·NCT05535075·155 enrolled

Pharmacokinetics Vancomycin CVVHDF with OXiris Membrane

Recruiting·MMahidol University·N/A·NCT06543940·8 enrolled

Infection Rates Between Using of Vancomycin Versus Gentamycin in Primary ACLR

Unknown status·—··NCT06050785·110 enrolled

Effect of Vancomycin After Catheter Replacement

Unknown status·UUniversity of Zurich·Phase 4·NCT04856878·100 enrolled

Treatment Algorithm to Reduce the Use of Vancomycin in Adults With Blood Stream Infection

Completed·—·Phase 2·NCT01191840·509 enrolled

A Phase 2a Study, Effect of Vancomycin With vs Without Delpazolid (LCB01-0371) in Patients With MRSA Bacteremia

Terminated·LLigaChem Biosciences, Inc.·Phase 2·NCT05225558·40 enrolled

Pharmacokinetics/ Pharmacodynamics (PK/PD) Study of Vancomycin

Unknown status·ZZhejiang University·Phase 4·NCT02443064·100 enrolled

Vancomycin in the Target Site Treatment of Intracranial Infection

Unknown status·XXijing Hospital·Phase 4·NCT03585426·2 enrolled

Neonatal Vancomycin Trial

Terminated·PPENTA Foundation·Phase 2·NCT02790996·242 enrolled

Loading Vancomycin Doses in the Emergency Department

Completed·CChristiana Care Health Services·N/A·NCT01162733·99 enrolled

First Time Right of Vancomycin

Not yet recruiting·EErasmus Medical Center·N/A·NCT05964114·134 enrolled

Clostridium Difficile Infection16 trials

Fecal Transplantation for Primary Clostridium Difficile Infection

Terminated·OOslo University Hospital·Phase 3·NCT03796650·104 enrolled

A Post-marketing, Blinded Study to Investigate How Effective Fidaxomicin is Compared to Vancomycin in the Sustained Cure of Clostridium Difficile Infection in Adults That Are Receiving Therapy to Suppress the Immune System

Terminated· Astellas logo

Astellas·Phase 4·NCT01775397·12 enrolled

A Phase IIIB/IV Study to Compare the Efficacy of Vancomycin Therapy to Extended Duration of Fidaxomicin Therapy in the Clinical Cure of Clostridium Difficile Infection (CDI) in an Older Population

Completed· Astellas logo

Astellas·Phase 4·NCT02254967·364 enrolled

Show 13 more trials

Use Of Oral Fidaxomicin Vs. Oral Vancomycin For Clostridium Difficile Infection In Patients With Spinal Cord Injury

Terminated·—·Phase 4·NCT02355938·12 enrolled

Rectal Bacteriotherapy, Fecal Microbiota Transplantation or Oral Vancomycin Treatment of Recurrent Clostridium Difficile Infections

Unknown status·HHvidovre University Hospital·Phase 3·NCT02774382·450 enrolled

Oral Vancomycin Versus Probiotics Versus Placebo for Prevention of Clostridium Difficile Infection in Colonized Patients

Withdrawn·HHamilton Health Sciences Corporation·Phase 1·NCT04246151

Comparison of Ridinilazole Versus Vancomycin Treatment for Clostridium Difficile Infection

Completed·SSummit Therapeutics·Phase 3·NCT03595553·759 enrolled

Fecal Microbiota Therapy for Recurrent Clostridium Difficile Infection

Unknown status·QQueen Elizabeth II Health Sciences Centre·Phase 2/3·NCT02686645·50 enrolled

Vancomycin Prophylaxis in Recurrent Clostridium Difficile Infection

Unknown status·CCorewell Health West·Phase 4·NCT02237859·140 enrolled

MET-2 Clinical Study for Recurrent Clostridium Difficile Infection (CDI)

Completed·NNuBiyota·Phase 1·NCT02865616·19 enrolled

Initial Vancomycin Taper for the Prevention of Recurrent Clostridium Difficile Infection

Completed·MMcGill University Health Centre/Research Institute of the McGill University Health Centre·Phase 3·NCT04138706·263 enrolled

Fecal Microbiota Transplantation for Relapsing Clostridium Difficile Infection

Completed·UUniversity of Aarhus·Phase 3·NCT02743234·64 enrolled

Efficacy of Oral Vancomycin Prophylaxis for Prevention of Recurrent Clostridium Difficile Infection

Completed·UUniversity of Wisconsin, Madison·Phase 2·NCT03462459·79 enrolled

Study of CB-183,315 in Participants With Clostridium Difficile Infection

Completed· Merck & Co. logo

Merck & Co.·Phase 2·NCT01085591·210 enrolled

Screening to Prophylax Against Clostridium Difficile Infection -

Completed·CCorewell Health East·Phase 4·NCT02996487·1,294 enrolled

Treatment of Initial Clostridium Difficile Infection

Completed·UUniversidad Autonoma de Nuevo Leon·N/A·NCT03107169·10 enrolled

Diarrhea10 trials

Efficacy and Safety of Cadazolid Versus Vancomycin in Subjects With Clostridium Difficile - Associated Diarrhea

Completed· Johnson & Johnson logo

Johnson & Johnson·Phase 3·NCT01987895·632 enrolled

Study of CB-183,315 in Participants With Clostridium Difficile Associated Diarrhea (MK-4261-005)

Completed· Merck & Co. logo

Merck & Co.·Phase 3·NCT01597505·606 enrolled

PAR-101/OPT-80 Versus Vancomycin for the Treatment of Clostridium Difficile-Associated Diarrhea (CDAD)

Completed· Merck & Co. logo

Merck & Co.·Phase 3·NCT00468728·535 enrolled

Show 7 more trials

Transplantation of Cultured Gut Microflora to Repeat Antibiotic-induced Diarrhea Due to Clostridium Difficile

Completed·PPer Hellström·Phase 2·NCT02857582·60 enrolled

Fidaxomicin Versus Vancomycin for the Treatment of Clostridium Difficile-Associated Diarrhea (CDAD) (MK-5119-018)

Completed· Merck & Co. logo

Merck & Co.·Phase 3·NCT00314951·629 enrolled

A Trial to Compare Xifaxan to Vancomycin for the Treatment of Clostridium Difficile-Associated Diarrhea (CDAD)

Completed·BBausch Health Americas, Inc.·Phase 3·NCT00269399·237 enrolled

A Study to Compare Safety and Efficacy of OPT-80(Fidaxomicin) With Vancomycin in Subjects With Clostridium Difficile-associated Diarrhea (CDAD)

Completed· Astellas logo

Astellas·Phase 3·NCT02179658·210 enrolled

Fecal Microbiota Transplantation for Primary Clostridium Difficile Diarrhea

Withdrawn·MMemorial University of Newfoundland·Phase 3·NCT02801656

Efficacy and Safety of Cadazolid Versus Vancomycin in Subjects With Clostridium Difficile-associated Diarrhea

Completed· Johnson & Johnson logo

Johnson & Johnson·Phase 3·NCT01983683·631 enrolled

Efficacy, Safety and Tolerability of Cadazolid in Subjects With Clostridium Difficile Associated Diarrhea (CDAD)

Completed· Johnson & Johnson logo

Johnson & Johnson·Phase 2·NCT01222702·84 enrolled

Antibiotics7 trials

Systems Biology of Flu Vaccine in Healthy Adults With and Without the Use of Antibiotics

Completed·EEmory University·N/A·NCT02154061·33 enrolled

Antibiotics Continuous Infusion at Home

Unknown status·OOspedale San Carlo Borromeo·Phase 1·NCT04816968·50 enrolled

Study of Antibiotics in Cerebrospinal Fluid Following Intravenous Injection

Withdrawn·—·Phase 1·NCT00925093

Show 4 more trials

A Comparison of Fidaxomicin and Vancomycin in Patients With CDI Receiving Antibiotics for Concurrent Infections

Completed·UUniversity of Michigan·Phase 4·NCT02692651·144 enrolled

Surgical Infection Rates With Adjunct Vancomycin Compared to Standard Peri-Operative IV Antibiotics

Unknown status·CCorewell Health West·N/A·NCT02299882·700 enrolled

Responses to Rabies Vaccine in Adults With or Without Antibiotics

Completed·EEmory University·Phase 4·NCT03557008·37 enrolled

Early Antibiotics After Aspiration in ICU Patients

Terminated·UUConn Health·Phase 4·NCT05079620·5 enrolled

Pneumonia6 trials

Evaluation of Patients With Methicillin-Resistant Staphylococcus Aureus Hospital-Acquired Pneumonia Treated With Linezolid or Vancomycin

Completed· Pfizer logo

Pfizer··NCT01561469·188 enrolled

Nosocomial Pneumonia With Suspected Or Proven Methicillin-Resistant Staphylococcus Aureus (MRSA)

Completed· Pfizer logo

Pfizer·Phase 4·NCT00084266·1,225 enrolled

Aerosolized Vancomycin in Methicillin-Resistant Staphylococcus Aureus Pneumonia Under Mechanical Ventilation

Completed·SSeoul National University Hospital·Phase 2·NCT01925066·20 enrolled

Show 3 more trials

Comparison of Telavancin and Vancomycin for Hospital-acquired Pneumonia Due to Methicillin-resistant Staphylococcus Aureus

Completed·CCumberland Pharmaceuticals·Phase 3·NCT00124020·771 enrolled

Clinical Outcomes of Methicillin Resistant Staphylococcus Aureus (MRSA) Hospital-Based Pneumonia

Completed· Pfizer logo

Pfizer··NCT01819935·5,271 enrolled

Clinical Efficacy of Intravenous Iclaprim Versus Vancomycin in the Treatment of Hospital-Acquired, Ventilator-Associated, or Health-Care-Associated Pneumonia

Terminated·AArpida AG·Phase 2·NCT00543608·135 enrolled

82 more indications

Infections6 trials

Study Comparing Cubicin With Vancomycin in Treatment of Participants With Complicated Skin and Skin Structure Infections in a Home Infusion Setting

Terminated· Merck & Co. logo

Merck & Co.·Phase 4·NCT01175707·80 enrolled

Dalbavancin for the Treatment of Acute Bacterial Skin and Skin Structure Infections in Children, Known or Suspected to be Caused by Susceptible Gram-positive Organisms, Including MRSA

Completed· AbbVie logo

AbbVie·Phase 3·NCT02814916·199 enrolled

Delafloxacin vs Vancomycin and Aztreonam for the Treatment of Acute Bacterial Skin and Skin Structure Infections

Completed·MMelinta Therapeutics, Inc.·Phase 3·NCT01984684·850 enrolled

Show 3 more trials

Intestinal Lavage for the Treatment of Severe C. Difficile Infections

Unknown status·LLondon Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's·Phase 2/3·NCT02466698·20 enrolled

Evaluation of Daptomycin for the Emergency Department Treatment of Complicated Skin and Skin Structure Infections

Completed·UUniversity of Cincinnati·Phase 4·NCT01549613·104 enrolled

Antibiotic Treatment for Infections of Short Term In-dwelling Vascular Catheters Due to Gram Positive Bacteria

Completed· Pfizer logo

Pfizer·Phase 3·NCT00037050·739 enrolled

Antibiotic6 trials

AbioKin - Antibiotic Kinetics

Completed·GGruppo Italiano per la Valutazione degli Interventi in Terapia Intensiva··NCT02609646·1,500 enrolled

Placement of Antibiotic Powder in Wounds During the Emergency Room

Recruiting·TThe University of Texas Health Science Center at San Antonio·Phase 4·NCT03765567·200 enrolled

Impact of Oral Antibiotic Treatment on C. Difficile

Completed·—·Phase 4·NCT02057198·33 enrolled

Show 3 more trials

Comparison of Teicoplanin and Vancomycin in Initial Empirical Antibiotic Regimen for Febrile Neutropenic Patients

Completed· Sanofi logo

Sanofi·Phase 4·NCT00454272·197 enrolled

IL-10 Stratifying Tool for Towards Antibiotic Selection for MRSaB

Completed·SSharp HealthCare·Phase 4·NCT02660346·40 enrolled

Intracameral Antibiotic Safety Study

Suspended·PPanhandle Eye Group, LLP·Phase 3·NCT02590523·500 enrolled

Safety and Efficacy5 trials

Phase 3 Study to Evaluate Safety and Efficacy of Iclaprim Versus Vancomycin for ABSSSI: REVIVE-2

Completed·MMotif Bio·Phase 3·NCT02607618·613 enrolled

Phase 3 Study to Evaluate Safety and Efficacy of Iclaprim Versus Vancomycin for ABSSSI: REVIVE-1

Completed·MMotif Bio·Phase 3·NCT02600611·600 enrolled

Phase 2 Safety and Efficacy Study of Daptomycin in Complicated Skin and Skin Structure Infections

Completed· Merck & Co. logo

Merck & Co.·Phase 2·NCT00426933·100 enrolled

Show 2 more trials

Study of Daptomycin Safety and Efficacy for Complicated Skin and Skin Structure Infections (cSSSI) and Bacteremia in Renal Impairment

Terminated· Merck & Co. logo

Merck & Co.·Phase 4·NCT01104662·92 enrolled

Study Comparing the Safety and Efficacy of Two Doses of BC-3781 vs Vancomycin in Patients With Acute Bacterial Skin and Skin Structure Infection (ABSSSI)

Completed·NNabriva Therapeutics AG·Phase 2·NCT01119105·210 enrolled

Skin Infection5 trials

China Registration Study in Patients With Skin Infections

Completed· AstraZeneca logo

AstraZeneca·Phase 3·NCT00772447·265 enrolled

Evaluation of Ceftaroline Fosamil vs Vancomycin Plus Aztreonam in the Treatment of Patients With Skin Infections.

Terminated· Pfizer logo

Pfizer·Phase 3·NCT02202135·4 enrolled

A Study to Assess Objective Endpoint Measurements of Response in Bacterial Skin Infections

Completed·MMelinta Therapeutics, Inc.·Phase 2·NCT01283581·256 enrolled

Show 2 more trials

Evaluation of Ceftaroline Fosamil Versus Vancomycin Plus Aztreonam in the Treatment of Patients With Skin Infections

Completed· Pfizer logo

Pfizer·Phase 3·NCT01499277·802 enrolled

Daptomycin Versus Vancomycin in Participants With Skin Infections Due to MRSA

Completed· Merck & Co. logo

Merck & Co.·Phase 4·NCT01419184·250 enrolled

Cardiac Surgery5 trials

Prevention of Infections in Cardiac Surgery

Terminated·HHamilton Health Sciences Corporation·N/A·NCT02285140·5,989 enrolled

Prevention of Infections in Cardiac Surgery (PICS): a Cluster-randomized Factorial Cross-over Trial

Not yet recruiting·HHamilton Health Sciences Corporation·Phase 4·NCT06567808·38,000 enrolled

Topical Use of Vancomycin in Reducing Sternal Wound Infection in Cardiac Surgery (SWI Trial)

Terminated·UUniversity of Alberta·Phase 2·NCT02374853·1,037 enrolled

Show 2 more trials

Prevention of Infections in Cardiac Surgery (PICS) Prevena Study

Completed·PPopulation Health Research Institute·Phase 4·NCT03402945·4,107 enrolled

Efficacy of Diluted Betadine vs Antibiotic Installation Before Surgical Wound Closure in Prevention of Post Cardiac Surgery Wound Infection

Unknown status·—·Phase 4·NCT05276687·80 enrolled

Sclerosing Cholangitis5 trials

Vancomycin for Primary Sclerosing Cholangitis

Completed·EElizabeth Carey·Phase 2/3·NCT03710122·102 enrolled

Effect and Safety of Oral Vancomycin in Primary Sclerosing Cholangitis Patients

Unknown status·TTehran University of Medical Sciences·Phase 4·NCT02605213·30 enrolled

A Pilot Study of Vancomycin or Metronidazole in Patients With Primary Sclerosing Cholangitis

Completed·MMayo Clinic·Phase 1·NCT01085760·35 enrolled

Show 2 more trials

Gastrointestinal Microbiota in Primary Sclerosing Cholangitis and Biliary Atresia With Vancomycin

Completed·SStanford University·Phase 1·NCT01322386·32 enrolled

A Pilot Study to Characterize Bile Acid Metabolism and Dysbiosis in Primary Sclerosing Cholangitis

Completed·UUniversity of Minnesota·Phase 1·NCT02464020·8 enrolled

Methicillin-resistant Staphylococcus Aureus5 trials

Skin Structure Infections With Suspected or Proven Methicillin-Resistant Staphylococcus Aureus (MRSA)

Completed· Pfizer logo

Pfizer·Phase 4·NCT00087490·1,077 enrolled

Comparison of Telavancin and Vancomycin for Complicated Skin and Skin Structure Infections With a Focus on Methicillin-resistant Staphylococcus Aureus

Completed·CCumberland Pharmaceuticals·Phase 3·NCT00107978·1,035 enrolled

Vancomycin Versus Daptomycin for the Treatment of Methicillin-resistant Staphylococcus Aureus Bacteremia Due to Isolates With High Vancomycin Minimum Inhibitory Concentrations (MICs)

Terminated·SSt. John Health System, Michigan·Phase 4·NCT01287832·11 enrolled

Show 2 more trials

Comparison of Telavancin and Vancomycin for Complicated Skin and Skin Structure Infections With a Focus on Methicillin-resistant Staphylococcus Aureus

Completed·CCumberland Pharmaceuticals·Phase 3·NCT00091819·862 enrolled

Prevention of Gastrostomy-Related Wound Infection by Vancomycin in Carriers of Methicillin-Resistant Staphylococcus Aureus.

Unknown status·UUniversity Hospital, Geneva·Phase 2·NCT00150852·96 enrolled

Osteomyelitis4 trials

Drug Delivery Devices for Osteomyelitis

Completed·—··NCT02968693·51 enrolled

Study of Daptomycin in Subjects Undergoing Surgery for Osteomyelitis Associated With an Infected Prosthetic Caused by Staphylococci

Completed· Merck & Co. logo

Merck & Co.·Phase 2·NCT00428844·75 enrolled

Vancomycin Or Trimethoprim/Sulfamethoxazole for Methicillin-resistant Staphylococcus Aureus Osteomyelitis

Completed·UUniversity of Washington·Phase 3·NCT00324922·2 enrolled

Show 1 more trial

Prospective, Randomized, Multicenter Clinical Trial of Bisphosphonates Combined With Vancomycin for the Treatment of Cierny-Mader Type I and III Osteomyelitis

Not yet recruiting·SSecond Affiliated Hospital, School of Medicine, Zhejiang University·Phase 3·NCT07435051·280 enrolled

Staphylococcus Aureus4 trials

Ceftobiprole in the Treatment of Resistant Staphylococcus Aureus Skin and Skin Structure Infections

Completed· Basilea Pharmaceutica logo

Basilea Pharmaceutica·Phase 3·NCT00228982·784 enrolled

A Phase 3 Telavancin Staphylococcus Aureus (S. Aureus) Bacteremia Trial

Terminated·CCumberland Pharmaceuticals·Phase 3·NCT02208063·121 enrolled

Staphylococcus Aureus Network Adaptive Platform Trial

Recruiting·UUniversity of Melbourne·Phase 4·NCT05137119·8,000 enrolled

Show 1 more trial

Vancomycin Versus Daptomycin for the Treatment of Methicillin Resistant Staphylococcus Aureus (MRSA) Bacteremia

Terminated·SSingapore General Hospital·Phase 2·NCT01975662·14 enrolled

Clostridium Difficile3 trials

Optimal Treatment for Recurrent Clostridium Difficile

Terminated·VVA Office of Research and Development·Phase 4·NCT02667418·308 enrolled

Study of Nitazoxanide in the Treatment of Clostridium Difficile-associated Disease

Terminated·RRomark Laboratories L.C.·Phase 3·NCT00384527·50 enrolled

A Study of SMT19969 Compared With Vancomycin for the Treatment of Clostridium Difficile-Associated Diarrhoea (CDAD)

Completed·SSummit Therapeutics·Phase 2·NCT02092935·100 enrolled

Ulcerative Colitis3 trials

A Phase 1b Trial to Evaluate the Safety of MB310 in Patients With Active, Mild-to-Moderate Ulcerative Colitis

Completed·MMicrobiotica Ltd·Phase 1·NCT06582264·29 enrolled

Antibiotics for the Treatment of Ulcerative Colitis

Completed·UUniversity of Dundee·N/A·NCT00355602·40 enrolled

Refined Fecal Microbiota Transplantation (FMT) for Ulcerative Colitis (UC)

Terminated·AAri M Grinspan·Phase 1·NCT04968951·4 enrolled

Surgical Site Infection3 trials

Study for Antibiotic Impregnated Calcium Sulfate Beads as Prophylaxis for Surgical Site Infection

Unknown status·MMcMaster University·Phase 4·NCT03308253·60 enrolled

The Effect of Intrawound Vancomycin Powder on Surgical Site Infection in Inguinal Lymph Node Dissection

Recruiting·WWomen and Infants Hospital of Rhode Island·Phase 2/3·NCT05625373·30 enrolled

Intra-wound Vancomycin Powder for Prevention of Surgical Site Infection Following Spinal Surgery

Recruiting·RRabin Medical Center·Phase 3·NCT05959603·363 enrolled

Staphylococcus Aureus Bacteremia2 trials

Staphylococcus Aureus Bacteremia Antibiotic Treatment Options

Completed·HHeinrich-Heine University, Duesseldorf·Phase 3·NCT01792804·215 enrolled

DOTS: Dalbavancin as an Option for Treatment of Staphylococcus Aureus Bacteremia

Completed·NNational Institute of Allergy and Infectious Diseases (NIAID)·Phase 2·NCT04775953·200 enrolled

Neutropenia2 trials

Short vs Prolonged Antibiotic Treatment for Hospitalized Hemato-oncology Patients With Febrile Neutropenia

Unknown status·TTel-Aviv Sourasky Medical Center·Phase 4·NCT02463747·110 enrolled

Meropenem Versus Meropenem Plus Glycopeptide in Patients With Febrile Neutropenia After Allogenic Blood Stem Cell Transplantation

Completed·PPETHEMA Foundation··NCT00462878·392 enrolled

Spinal Fusion2 trials

Intrawound Vancomycin Powder in Spinal Fusion Surgery

Completed·—·Phase 4·NCT02631408·308 enrolled

Suprafascial Vancomycin Powder for Prevention of Surgical Site Infections After Instrumented Posterior Spinal Fusion

Active, not recruiting·IInsel Gruppe AG, University Hospital Bern·Phase 2·NCT04017468·450 enrolled

Infective Endocarditis2 trials

Vancomycin, Gentamycin in Infective Endocarditis

Unknown status·—·N/A·NCT03688659·30 enrolled

Fosfomycin Plus Imipenem for Treatment of Infective Endocarditis

Completed·JJuan A. Arnaiz·Phase 4·NCT00871104·50 enrolled

Infection2 trials

Clostridioides Difficile Controlled Human Infection Model

Not yet recruiting·LLeiden University Medical Center·N/A·NCT06702345·60 enrolled

TD-1792 in Gram-positive Complicated Skin and Skin Structure Infection

Completed·TTheravance Biopharma·Phase 2·NCT00442832·203 enrolled

Colitis2 trials

Intracolonic Vancomycin Therapy in Severe C. Diff Colitis

Terminated·CCorewell Health East·N/A·NCT01346059·2 enrolled

Fecal Microbiota Transplantation in Recurrent or Refractory Clostridium Difficile Colitis

Unknown status·UUniversity Hospital Tuebingen·N/A·NCT01942447·30 enrolled

Acute Kidney Injury2 trials

Vancomycin-Associated Acute Kidney Injury: A Cross-Sectional Study From a Multi- Center in China

Unknown status·PPeking University First Hospital··NCT03456544·10,000 enrolled

A Pragmatic Clinical Trial Comparing the Risk of Acute Kidney Injury During Treatment With Vancomycin and Piperacillin-Tazobactam vs. Vancomycin and Cefepime in Hospitalized Patients

Recruiting·UUniversity of Pennsylvania·Phase 4·NCT06954129·750 enrolled

Crohn's Disease2 trials

Fundamental Modification of the Gut Microbiota in the Treatment of Refractory Crohn's Disease

Completed·UUniversity of Pennsylvania·Phase 2·NCT02765256·8 enrolled

Pilot Study of Fundamental Modification of the Gut Microbiota in the Treatment of Refractory Crohn's Disease

Completed·—·Phase 2·NCT03476317·10 enrolled

Spine Surgery2 trials

The Effect of Intrawound Vancomycin Powder in Spine Surgery

Recruiting·WWindsor-Essex Compassionate Care Community·Phase 4·NCT04825522·1,643 enrolled

Irrisept Solution for Instrumented Spine Surgery

Recruiting·RRhode Island Hospital·N/A·NCT06439953·200 enrolled

Total Knee Arthroplasty2 trials

A Prospective, Randomized Parallel Group Study of the Efficacy of Vancomycin Administered Through Intraarticular Injection Versus Intraosseous Injection Versus Intravenous Infusion in Patients Undergoing Total Knee Arthroplasty

Recruiting·UUniversity of California, San Diego·Phase 4·NCT07282782·30 enrolled

Effectiveness of Adding Morphine to Intraosseous Vancomycin for Pain Control in Total Knee Arthroplasty

Completed·CCarilion Clinic·Phase 2·NCT06716749·100 enrolled

Total Knee Replacement2 trials

Regional Prophylactic Vancomycin With Restricted Tourniquet Time in Primary Total Knee Replacement

Completed·MMayo Clinic·Phase 2/3·NCT03506347·24 enrolled

Regional Prophylactic Vancomycin in Revision Total Knee Replacement

Completed·MMayo Clinic·Phase 2/3·NCT02020031·22 enrolled

Gut Microbiome2 trials

Effect of Antibiotics on Gut Microbiome and Plasma Metabolome

Completed·FFinnish Institute for Health and Welfare·Phase 4·NCT03273296·39 enrolled

The Effect of an Antibiotic on the Production of Uremic Toxins by the Gut Microbiome

Completed·NNYU Langone Health·Phase 2·NCT03452189·15 enrolled

Intravenous Administration2 trials

Evaluating the Use of Large-dose, Extended Interval Vancomycin Intravenous Administration for Skin and Soft Tissue Infections

Completed·FFraser Health·N/A·NCT01037192·4 enrolled

Vancomycin Tissue Concentrations by Bier Block or Intravenous Administration

Completed·MMayo Clinic·Phase 1·NCT04673877·20 enrolled

Diabetic Foot2 trials

Outpatient Treatment of Gram Positive Wound Infections in the Diabetic Foot: A Pharmaco-economic Comparison of Daptomycin vs. Vancomycin Based Regimens

Terminated·CClinical Alliance for Research & Education - Infectious Diseases, LLC.·Phase 4·NCT01133600·6 enrolled

Application of Daptomycin in MRSA Infected Diabetic Foot in Comparison to Vancomycin Treatment

Terminated·RRuhr University of Bochum·Phase 3·NCT01199783·1 enrolled

Critically Ill Patients2 trials

Cystatin-C C-guided Vancomycin Dosing in Critically Ill Patients: A Quality Improvement Project

Completed·MMayo Clinic·Phase 1·NCT02945241·399 enrolled

Utility of Vancomycin Loading: A Pharmacokinetic Analysis in Critically Ill Patients

Terminated·MM.D. Anderson Cancer Center·N/A·NCT01157533·1 enrolled

Surgical Site Infections2 trials

Delafloxacin IV and OS Administration Compared to Best Available Therapy in Patients With Surgical Site Infections

Terminated· Menarini logo

Menarini·Phase 3·NCT04042077·268 enrolled

Checklist to Prevent MRSA Surgical Site Infections

Completed·VVA Office of Research and Development·N/A·NCT02216227·1,794 enrolled

Clostridioides difficile Infection2 trials

ACX-362E [Ibezapolstat] for Oral Treatment of Clostridioides Difficile Infection

Completed·AAcurx Pharmaceuticals Inc.·Phase 2·NCT04247542·53 enrolled

Lyophilized Fecal Microbiome Transfer vs. Vancomycin Monotherapy for Primary Clostridioides Difficile Infection

Recruiting·RRambam Health Care Campus·N/A·NCT05709184·196 enrolled

Soft Tissue Infections1 trial

Efficacy and Safety of Daptomycin Versus Vancomycin or Teicoplanin for Treatment of Complicated Skin and Soft Tissue Infections

Terminated· Novartis logo

Novartis·Phase 3·NCT00430937·194 enrolled

Antibiotic Therapy1 trial

Optimized Antibiotic Therapy in Patients With Subarachnoid Haemorrhage (ES) and Cerebral Haemorrhage (EC)

Unknown status·AAzienda Sanitaria-Universitaria Integrata di Udine··NCT04132115·104 enrolled

Methicillin-Resistant Staphylococcus Aureus Infection1 trial

Cotrimoxazole Versus Vancomycin for Invasive Methicillin-resistant Staphylococcus Aureus Infections

Completed·RRabin Medical Center·Phase 3·NCT00427076·252 enrolled

Cirrhosis1 trial

Empirical vs 2nd Line Antibiotic Therapy in Health-care Associated Infections in Cirrhosis

Unknown status·UUniversity of Roma La Sapienza·Phase 4·NCT01820026·96 enrolled

Hematologic Cancer1 trial

Prevention of Infection in Patients With Hematologic Cancer and Persistent Fever Caused by a Low White Blood Cell Count

Completed·EEuropean Organisation for Research and Treatment of Cancer - EORTC·Phase 3·NCT00003805·859 enrolled

Immune Response1 trial

The Role of the Microbiota in the Systemic Immune Response

Completed·—·N/A·NCT02340182·12 enrolled

Fecal Microbiota Transplantation1 trial

Application of Fecal Microbiota Transplantation in Children With ASD

Unknown status·TTongji Hospital·Phase 1·NCT04948814·40 enrolled

Multiple Sclerosis1 trial

Vancomycin Study in Multiple Sclerosis (MS)

Recruiting·IIcahn School of Medicine at Mount Sinai·Phase 1·NCT05539729·12 enrolled

Hepatocellular Carcinoma1 trial

Vancomycin in Patients With Unresectable Fibrolamellar Hepatocellular Carcinoma (FLC) Oral

Withdrawn·NNational Cancer Institute (NCI)·Phase 2·NCT04025567

Preoperative1 trial

Preoperative Antibiotics for Carpal Tunnel Release Surgery

Completed·WWellSpan Health·Phase 4·NCT03432858·184 enrolled

Cancer1 trial

Comparative Study of Ceftazidime-Avibactam Versus Standard of Care as Therapy in Febrile Neutropenic Adults With Cancer

Terminated·FForest Laboratories·Phase 2·NCT02732327·2 enrolled

Open Fracture1 trial

Local Application of Vancomycin Powder in Grade I-IIIA Open Fractures

Terminated·UUniversity of Tennessee·Phase 4·NCT02400112·11 enrolled

Wound Infection1 trial

To Assess Use of Vancomycin Powder in Craniotomy on Wound Infection Rates

Unknown status·—·Phase 4·NCT04917627·500 enrolled

Effectiveness1 trial

The Effectiveness of Vancomycin in Comarison With Cefazolin in Prevention of SSI After Craniotomy

Unknown status·IIsfahan University of Medical Sciences·Phase 1/2·NCT03466645·126 enrolled

Prospective1 trial

PHASE II SINGLE-CENTER, RANDOMIZED, OPEN-LABEL, PROSPECTIVE, STUDY TO DETERMINE THE IMPACT OF SERIAL PROCALCITONIN

Completed·MM.D. Anderson Cancer Center·Phase 2·NCT04983901·100 enrolled

Adolescent1 trial

Safety, Tolerability and the Pharmacokinetics of Ridinilazole in Adolescent Subjects

Terminated·SSummit Therapeutics·Phase 3·NCT04802837·2 enrolled

Outcome1 trial

Clinical and Economic Outcomes of Ceftaroline Fosamil for ABSSSI Documented or at Risk of MRSA

Completed·WWayne State University·Phase 4·NCT02582203·174 enrolled

Autism Spectrum Disorder1 trial

Microbiota Transfer Therapy for Adults With Autism Spectrum Disorder (ASD) Who Have Gastrointestinal Disorders

Active, not recruiting·—·Phase 2·NCT03408886·55 enrolled

Liver Transplant1 trial

Vancomycin Treatment in Recurrent PSC in Liver Transplant Patients

Withdrawn·OOchsner Health System·N/A·NCT03046901

Rheumatoid Arthritis1 trial

Role of Oral and Intestinal Microbiota in Rheumatoid Arthritis (RA)

Completed·NNYU Langone Health·N/A·NCT01198509·178 enrolled

Fidaxomicin1 trial

Study to Assess Inhibition of Spore Production in Patients With C. Difficile Infections: Fidaxomicin Versus Vancomycin

Completed·HHartford Hospital·Phase 4·NCT01818141·34 enrolled

Concentration1 trial

Steady State Serum and Epithelial Lining Fluid (ELF) Antibiotics Concentrations Under Continous Infusion

Terminated·UUniversity Hospital Tuebingen··NCT00435305·40 enrolled

Cystic Fibrosis1 trial

Pharmacokinetics of Vancomycin for Inhalation in Cystic Fibrosis

Withdrawn·—·Phase 1·NCT01509339

Critically Ill1 trial

Precision Dosing of Vancomycin in Critically Ill Children

Completed·UUniversity Hospital, Ghent·Phase 4·NCT04666948·314 enrolled

Prosthetic-joint Infection1 trial

Efficacy and Safety Study of Antibiotic Treatment to Treat Hip Prosthetic Joint Infection

Unknown status·UUniversity Hospital, Tours·Phase 2·NCT01757236·100 enrolled

Gut Microbiota1 trial

Investigation of the Gut Microbiota in Regulating Nutrient Absorption in Humans

Completed·NNational Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)·Phase 2·NCT02037295·27 enrolled

Ventilator-Associated Pneumonia1 trial

Microbiologic Response With Linezolid And Vancomycin In Ventilator-Associated Pneumonia Due To Methicillin Resistant Staphylococcus Aureus

Completed· Pfizer logo

Pfizer·Phase 4·NCT00572559·149 enrolled

Metastatic Colorectal Cancer1 trial

Fecal Microbiota Transplant and Re-introduction of Anti-PD-1 Therapy (Pembrolizumab or Nivolumab) for the Treatment of Metastatic Colorectal Cancer in Anti-PD-1 Non-responders

Active, not recruiting·MM.D. Anderson Cancer Center·Phase 2·NCT04729322·15 enrolled

Prevention1 trial

Prevention of Infection in Closed Fractures: Cefazolin Versus Vancomycin

Terminated·UUniversity of Tennessee·N/A·NCT02027532·430 enrolled

Metabolic Syndrome1 trial

Interventional Bioremediation of Microbiota in Metabolic Syndrome

Terminated·UUniversity of Minnesota·Phase 2·NCT02730962·12 enrolled

Randomized1 trial

Vancomycin Dosing for Serious MRSA Infections: A Non-inferiority Randomized Trial of Trough Level Versus AUC/MIC

Recruiting·AAnthony Bai·N/A·NCT04793152·700 enrolled

Surgical Wound Infection1 trial

Prevention of Neurosurgical Wound Infections

Completed·OOregon Health and Science University·N/A·NCT00915967·214 enrolled

Heart Failure1 trial

Intestinal Microbiota Transplantation in Patients With Chronic Heart Failure

Recruiting·MMelana Yuzefpolskaya, MD·Phase 1·NCT07490054·40 enrolled

Endothelial Function1 trial

Effect of Probiotic Supplementation on Endothelial Function

Completed·MMedical College of Wisconsin·Phase 4·NCT01952834·21 enrolled

Hematopoietic Stem Cell Transplant1 trial

Prevention of C.Difficile Infections With Oral Vancomycine in Patients Undergoing Allogeneic Hematopoietic Stem Cell Transplant

Unknown status·AAssistance Publique - Hôpitaux de Paris·Phase 3·NCT05256693·336 enrolled

Osteoarticular Infections1 trial

Dalbavancin For The Treatment of Gram Positive Osteoarticular Infections

Completed·IInfectious Diseases Physicians, Inc.·Phase 4·NCT03426761·41 enrolled

Hospitalized Patients1 trial

Cost Study of Linezolid Versus Vancomycin Among Previously Hospitalized Patients

Completed· Pfizer logo

Pfizer··NCT01363271·7,260 enrolled

Mortality1 trial

Impact of Treatment With Colistin on Mortality Bacteremia Multiresistant Acinetobacter Baumannii Sensitive Colistin in Patients Critical

Completed·MMaimónides Biomedical Research Institute of Córdoba··NCT02573064·113 enrolled

Peritoneal Dialysis1 trial

Vancomycin Pharmacokinetics in Patients on Peritoneal Dialysis

Completed·TThomas Jefferson University·Phase 1·NCT03685747·4 enrolled

Clinical Trial1 trial

A Clinical Trial for Analysis of Intestinal Microbiome Affecting PK, PD, and Safety of Metformin

Completed·SSeoul National University Hospital·N/A·NCT03809260·20 enrolled

Catheter Related Bloodstream Infection1 trial

Vancomycin Study: Treatment of Catheter Related Bloodstream Infection Caused by Coagulase Negative Staphylococcus

Completed·UUniversity of British Columbia·N/A·NCT00175370·60 enrolled

Cellulitis1 trial

Study Comparing CUBICIN® (Daptomycin for Injection) With Vancomycin in Cellulitis or Erysipelas

Completed· Merck & Co. logo

Merck & Co.·Phase 4·NCT00295178·80 enrolled

Renal Replacement Therapy1 trial

Safety and TDM of Continuous Infusion Vancomycin Through Continuous Renal Replacement Therapy Solution

Unknown status·—·Phase 1·NCT02663596·10 enrolled

Melanoma1 trial

A Phase 1b Trial to Evaluate Safety of MB097 in Combination With Pembrolizumab in Melanoma Patients

Active, not recruiting·MMicrobiotica Ltd·Phase 1·NCT06540391·41 enrolled

Treatment1 trial

Treatment of Neutropenic Patients With Fever Who Are Suspected to Have A Gram Positive Infection

Completed· Pfizer logo

Pfizer·Phase 3·NCT00035425·120 enrolled

Neurosurgery1 trial

Topical Vancomycin for Neurosurgery Wound Prophylaxis

Completed·—·Phase 3·NCT02284126·1,103 enrolled

Probiotic Intervention1 trial

Maternal Probiotic Intervention to Improve Gut Health - Trial II - Bangladesh

Enrolling by invitation·IInternational Centre for Diarrhoeal Disease Research, Bangladesh·Phase 2·NCT06817031·144 enrolled

Peritonitis1 trial

Vancomycin Plus Moxifloxacin Versus Vancomycin Plus Ceftazidime for the Treatment of Peritoneal Dialysis (PD)-Related Peritonitis

Completed·PPeking University First Hospital·N/A·NCT02787057·80 enrolled

Renal Failure1 trial

Acute Renal Failure in the Surgical Intense Care Units - NTUH-SICU-ARF (NSARF) Study

Unknown status·NNational Taiwan University Hospital·N/A·NCT00451373·300 enrolled

Non-Small Cell Lung Cancer1 trial

Safety Trial of Antimicrobial Therapy and Precision Radiation Therapy in Patients With Oligoprogressive Non-small Cell Lung Cancer

Recruiting·—·Phase 1·NCT03546829·10 enrolled

Chronic Rhinosinusitis1 trial

Topical Antibiotics in Chronic Rhinosinusitis

Completed·MMayo Clinic·Phase 1/2·NCT03673956·19 enrolled

Insulin Sensitivity1 trial

The Importance of the Gut Microbiota in Body Weight Control and Insulin Sensitivity

Completed·MMaastricht University Medical Center·N/A·NCT02241421·57 enrolled

Sepsis1 trial

Neonatal Suspected Sepsis Treated With Cefazolin or Vancomycin

Completed·HHospital Italiano de Buenos Aires·Phase 3·NCT01867138·109 enrolled

Regulatory

FDA Approval Timeline[5]

Apr 15, 1986

VANCOCIN HYDROCHLORIDE

NDA NDA050606

Mar 1, 1999

VANCOMYCIN HYDROCHLORIDE IN PLASTIC CONTAINER

NDA NDA050671

Jan 26, 2018

FIRVANQ KIT

NDA NDA208910

Jul 10, 2018

VANCOMYCIN HYDROCHLORIDE

NDA NDA209481

Feb 15, 2019

TYZAVAN

NDA NDA211962

Aug 26, 2021

VANCOMYCIN

NDA NDA213895

Jan 20, 2023

VANCOMYCIN HYDROCHLORIDE

NDA NDA210274

Sources

References

[1]
ClinicalTrials.gov — 271 trial records for Vancomycin. U.S. National Library of Medicine, National Institutes of Health.
[2]
MedlinePlus Drug Information — Vancocin drug information. U.S. National Library of Medicine, National Institutes of Health.
[3]
ChEMBL — Vancomycin compound record. European Bioinformatics Institute (EMBL-EBI).
[4]
Open Targets Platform — Drug–disease associations for Vancomycin. EMBL-EBI & Wellcome Sanger Institute.
[5]
OpenFDA — FDA approval records (NDA NDA210274). U.S. Food & Drug Administration.
[6]
FDA Orange Book — Patent and exclusivity data for Vancocin. U.S. Food & Drug Administration.
[7]
SEC EDGAR — Hikma Pharmaceuticals LLC company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[3]
Highest Phase: Approved[1]
Company: HHikma Pharmaceuticals LLC

Patent Landscape[6]

Patent Cliff

Mar 13, 2035

Earliest patent expiration — generic entry possible after this date

Patent #Expires

10959946Mar 13, 2035

10959947Mar 13, 2035

10959948Mar 13, 2035

10959949Mar 13, 2035

11638692Mar 13, 2035

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