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Cardiovascular/Aneurysm

Aneurysm

28

Pipeline Programs↗

82

Active Trials↗

36

Companies Involved↗

Aneurysm is an emerging landscape with 28 programs across 36 companies. 1 program is in Phase 3.

Intelligence

Pipeline Metrics

Competitive Density

64/100

Pipeline Velocity

63/100

Mech. Concentration

18/100

Completion Rate

79/100

Attrition Rate

7/100

Pipeline

Programs by Phase

Preclinical24

Heparin

Baxter Healthcare Corporation

Atenolol

Twinpig Biolab, Inc.

Ropivacaine

Fresenius Kabi USA, LLC

Lidocaine

MEDRx USA, Inc.

Isoflurane

Baxter Healthcare Corporation

Phase 1

No programs

Phase 23

Infliximab

Johnson & Johnson

Fludrocortisone

Jazz Pharmaceuticals

Allogeneic CART-NKG2D Cells

Instituto de Investigación Hospital Universitario La Paz

Phase 31

Ticagrelor or Prasugrel .

Federal State Budgetary Institution, V. A. Almazov Federal North-West Medical Research Centre, of the Ministry of Health

Approved

No programs

Analysis

Modality Breakdown

92%

Small molecule

22 of 24 classified programs — the dominant modality here.

Small molecule leads; the ring shows all 24 classified programs, each share of the total. Modality classified for 100% of 28 pipeline programs.

Analysis

Trial Status

178

clinical trials

Completed54 · 30%

Recruiting49 · 28%

Unknown status28 · 16%

Not yet recruiting18 · 10%

Active, not recruiting12 · 7%

Terminated8 · 4%

Other9 · 5%

Clinical Trials

Trial Activity

178 trials

Laser In Situ Fenestration for Endovascular Aortic Repair (LIFE) Study

Recruiting·—·Preclinical·NCT06411990·15 enrolled

Zenith® Fenestrated+ Endovascular Graft Clinical Study

Recruiting·CCook Group Incorporated·Preclinical·NCT04875429·105 enrolled

Evaluation Of Cost-Effectiveness Of Iliac Branch Endoprostheses: A Multi-Center, Retrospective-Prospective, Observational Study/ Eunet-Hta Core Model

Recruiting·—·N/A·NCT07096388·300 enrolled

A Multicenter Prospective Study of New Flow Diverter Stent on the Treatment of Intracranial Aneurysms in China

Recruiting·BBeijing Tiantan Hospital·Preclinical·NCT07821957·280 enrolled

Early Feasibility Study of the GORE® Multibranch Arch Endoprosthesis (MBA Device)

Recruiting·WW.L.Gore & Associates·Preclinical·NCT07564375·20 enrolled

NeuroVascular Product Surveillance Registry (PSR) Platform

Recruiting·MMedtronic Neurovascular Clinical Affairs·N/A·NCT02988128·4,000 enrolled

Aneurysm Treatment Using the Heli-FX™ EndoAnchor™ System China Study(ATHENA)

Recruiting·—·Preclinical·NCT07754318·142 enrolled

Cerebral Protection in Aortic Arch Surgery

Recruiting·BBarts & The London NHS Trust·N/A·NCT04966247·40 enrolled

Evaluating Oral Peri-operative Acetylsalicylic Acid in Subjects Undergoing Endovascular Coiling-only of Unruptured Brain Aneurysms(EVOLVE): A Phase 3 Multicenter Randomized Study

Recruiting·UUniversity of Calgary·Phase 3·NCT04192955·440 enrolled

Multimodal Biocollection Linked to the French Register of Intracranial Aneurysms

Recruiting·NNantes University Hospital·Preclinical·NCT06689410·1,100 enrolled

A Multicenter, Prospective, Single-Arm Observational Study to Evaluate the Safety and Effectiveness of the Choydar Flow-Directed Mesh Stent in the Treatment of Unruptured Intracranial Aneurysms

Recruiting·JJohnson & Johnson Medical (Shanghai) Ltd.·N/A·NCT07228312·200 enrolled

Clinical Outcomes and Quality of Life Measures in Patients Treated for Complex Abdominal, Thoracoabdominal and Aortic Arch Aneurysms or Dissections With Fenestrated and Branched Stent Grafts

Recruiting·—·Preclinical·NCT02089607·760 enrolled

Artisse™ Intrasaccular Device IDE

Recruiting·MMedtronic Neurovascular Clinical Affairs·Preclinical·NCT02998229·300 enrolled

General Anesthesia vs Local Anesthesia for Endovascular Treatment in Patients With Unruptured Intracranial Aneurysm Using Flow Diverter: an Exploratory Randomized Clinical Trial

Recruiting·—·Preclinical·NCT06416657·188 enrolled

A Prospective and Retrospective, Multi-Centre, Post-Market, Non-Interventional Study of Terumo Aortic Knitted and Woven Grafts, and Cardiovascular Patches

Recruiting·VVascutek Ltd.·N/A·NCT04545502·2,000 enrolled

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Data sources: ClinicalTrials.gov (NIH) · OpenFDA (FDA) · ChEMBL (EMBL-EBI) · Open Targets (EBI/Sanger) · MedlinePlus (NIH) · PubMed (NIH) · SEC EDGAR (SEC)