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Tenormin

(Atenolol)

ApprovedSmall molecule

TTwinpig Biolab, Inc.

Atenolol is used to treat high blood pressure and heart conditions like angina and irregular heartbeats. It works by slowing your heart rate and reducing the force of your heart's contractions, which helps lower blood pressure and reduces the heart's workload.[2] Tenormin is currently approved and in use across 30 indications[4].[1]

Tenormin is one of 625 small molecule programs targeting Coronary Artery Disease. It is currently in Approved.

30

Indications

71

Total Trials

4

Active Trials

624

Competitors

2

FDA Applications

NDA/BLA/ANDA regulatory filings

Pipeline

Status by Indication[4][1]

Indication

Coronary Artery DiseaseActive, not recruiting

CachexiaActive, not recruiting

HemangiomaActive, not recruiting

Cardiovascular DiseaseActive, not recruiting

Endothelial DysfunctionActive, not recruiting

Essential HypertensionActive, not recruiting

IschemiaActive, not recruiting

StrokeActive, not recruiting

Orthostatic IntoleranceApproved

Angina PectorisActive, not recruiting

Coronary Artery DiseasePhase 2/Phase 3

Active, not recruiting

CachexiaPreclinical

Active, not recruiting

HemangiomaPhase 3

Active, not recruiting

Cardiovascular DiseaseApproved

Active, not recruiting

Endothelial DysfunctionApproved

Active, not recruiting

Essential HypertensionApproved

Active, not recruiting

IschemiaPhase 3

Active, not recruiting

StrokeApproved

Active, not recruiting

Orthostatic IntoleranceApproved

Approved

Angina PectorisApproved

Active, not recruiting

Showing 10 of 30 indications

Competition

Competitive Landscape

885 competitors in Type 2 Diabetes

#DrugCompanyPhaseTrials

Tenormin

TTwinpig Biolab, Inc.

Byetta

Jardiance

Boehringer Ingelheim

NOVOLIN R

Cysteine Hydrochloride

Glargine

Inspra

PPfizer's Upjohn has merged with Mylan to form Viatris Inc.

Aurlumyn

BBTG International Inc.

Nexium

DDexcel Pharma Technologies Ltd.

Pravachol

KKaruna Therapeutics, Inc., a Bristol Myers Squibb company

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Clinical

Trials by Indication[1]

Hypertension6 trials

An Active-controlled, Clinical Trial to Assess Central Hemodynamic Effects of Bisoprolol in Hypertensive Patients (Central Hemodynamic Assessment Measured in Patient With HypertensION [CHAMPION])

Completed· Merck & Co. logo

Merck & Co.·Phase 4·NCT01079962·209 enrolled

Black Education and Treatment of Hypertension (BEAT HTN)

Completed·—·Phase 4·NCT00661895·99 enrolled

Hypertension in Hemodialysis Patients (Aim 3)

Terminated·IIndiana University·Phase 3·NCT00582114·200 enrolled

Show 3 more trials

Evaluation of Periop Biochemical Stress Factors in Craniotomy Neurosurgical Procedure With Respect to Preop Hypertension

Completed·MMilton S. Hershey Medical Center·Phase 4·NCT02441842·85 enrolled

Systolic Hypertension in the Elderly Program (SHEP)

Completed·NNational Heart, Lung, and Blood Institute (NHLBI)·Phase 3·NCT00000514

Matão Controlling Hypertension (MatCH Study): Rationale and Design

Unknown status·CCentro Neurológico de Pesquisa e Reabiitação, Brazil·Phase 1·NCT03147092·15,000 enrolled

Blood Pressure5 trials

Study of Atenolol Influence on Blood Pressure During Resistance Exercise

Completed·UUniversity of Sao Paulo·Phase 4·NCT01030016·10 enrolled

Effect of Carvedilol Controlled-Release (CR) and Atenolol on Central Blood Pressure

Completed·UUniversity of Florida·Phase 4·NCT00669279·41 enrolled

Clinical Study to Investigate Safety and Effects on Heart Rate, Blood Pressure, and Pharmacokinetic Interactions of ACT-334441

Terminated·VViatris Innovation GmbH·Phase 1·NCT02479204·10 enrolled

Show 2 more trials

Clinical Study to Evaluate the Antihypertensive Efficacy and Changes of Neurohormonal Markers of Fimasartan and Atenolol With Exaggerated Blood Pressure Response During Exercise in Essential Hypertensive Patients

Completed· Boryung Pharmaceutical Co., Ltd logo

Boryung Pharmaceutical Co., Ltd·Phase 4·NCT01736488·25 enrolled

A Safety Evaluation of ECG Intervals and Blood Pressure in Normal Healthy Volunteers After Use of Nebivolol, Atenolol, Moxifloxacin, or Placebo

Completed·MMylan Bertek Pharmaceuticals·Phase 1·NCT00158093·260 enrolled

Marfan syndrome5 trials

Comparison of Two Medications Aimed at Slowing Aortic Root Enlargement in Individuals With Marfan Syndrome

Completed·CCarelon Research·Phase 3·NCT00429364·608 enrolled

Atenolol Versus Losartan in the Prevention of Progressive Dilation of the Aorta in Marfan Syndrome

Unknown status·—·Phase 3·NCT01145612·140 enrolled

Effects of Losartan Versus Atenolol on Aortic and Cardiac Muscle Stiffness in Adults With Marfan Syndrome

Completed·—·Phase 3·NCT00723801·40 enrolled

Show 2 more trials

Comparison of Medical Therapies in Marfan Syndrome.

Completed·—·Phase 4·NCT01295047·18 enrolled

Losartan Versus Atenolol for the Treatment of Marfan Syndrome

Completed·UUniversity of British Columbia·Phase 2·NCT00593710·17 enrolled

Essential Hypertension3 trials

A Randomized Controlled Study to Assess the Effects of Bisoprolol and Atenolol on Resting Heart Rate and Sympathetic Nervous System's Activity in Subjects With Essential Hypertension

Completed· Merck & Co. logo

Merck & Co.·Phase 4·NCT01251146·177 enrolled

Effects of Bisoprolol and Atenolol on Sympathetic Nervous Activity and Central Aortic Pressure in Patients With Essential Hypertension

Completed·RRuijin Hospital·Phase 4·NCT01762436·109 enrolled

Effect of the Fixed Dose Combination Amlodipine/Valsartan on Central Aortic Blood Pressure in Uncontrolled Essential Hypertension With Amlodipine 5 mg

Completed· Novartis logo

Novartis·Phase 4·NCT00687973·393 enrolled

Safety and Efficacy2 trials

Safety and Efficacy of Valsartan vs Atenolol and Hydrochlorothiazide Combination on Blood Flow in Hypertensive Patients

Completed· Novartis logo

Novartis·Phase 3·NCT00396656·30 enrolled

To Assess the Anti-anginal Safety and Efficacy of Ivabradine in Subjects With Stable，Symptomatic Chronic Angina

Unknown status·XXintong Pharmacy Company·Phase 2·NCT02623569·336 enrolled

42 more indications

Type 2 Diabetes2 trials

Nephropathy In Type 2 Diabetes and Cardio-renal Events

Completed·UUniversity of Campania Luigi Vanvitelli·Phase 4·NCT00535925·850 enrolled

Examining Genetic Influence on Response to Beta-Blocker Medications in People With Type 2 Diabetes

Terminated·UUniversity of Maryland, Baltimore·Phase 4·NCT00925119·31 enrolled

Hypertensive2 trials

Trial of Antihypertensive Intervention Management

Completed·NNational Heart, Lung, and Blood Institute (NHLBI)·Phase 3·NCT00000513

Pharmacogenomic Evaluation of Antihypertensive Responses

Completed·UUniversity of Florida·Phase 4·NCT00246519·1,701 enrolled

Hemangioma2 trials

Efficacy and Safety of Propranolol Versus Atenolol on the Proliferative Phase of Infantile Hemangioma

Completed·WWest China Hospital·Phase 3·NCT02342275·377 enrolled

Comparative Study to Evaluate the Effectiveness of Atenolol and Propranolol in the Treatment of Infantile Hemangiomas

Unknown status·PPost Graduate Institute of Medical Education and Research, Chandigarh·Phase 3·NCT03237637·60 enrolled

Overweight2 trials

VALENCE: Valsartan Versus Atenolol on Exercise Capacity in Hypertensive Overweight Postmenopausal Women

Completed· Novartis logo

Novartis·Phase 4·NCT00171132·64 enrolled

A Comparison of the Effect of Olmesartan Medoxomil, Losartan Potassium, and Atenolol on the Ability of Overweight Patients With High Blood Pressure to Respond to Insulin

Completed· Daiichi Sankyo logo

Daiichi Sankyo·Phase 4·NCT00185094·60 enrolled

Regression2 trials

The CLEVER Study - Coreg And Left Ventricular Mass Regression

Completed· GSK logo

GSK·Phase 3·NCT00108082·287 enrolled

The Confirmatory Olmesartan Plaque Regression Study

Terminated· Daiichi Sankyo logo

Daiichi Sankyo·Phase 4·NCT01132768·114 enrolled

Oral1 trial

Effect of SLCO2B1 Genotype and Apple Juice on Pharmacokinetics of Atenolol After Oral Administration in Healthy Male Korean

Completed·SSeoul National University Hospital·Phase 4·NCT01445964·12 enrolled

Ischemia1 trial

Asymptomatic Cardiac Ischemia Pilot (ACIP) Study

Completed·NNational Heart, Lung, and Blood Institute (NHLBI)·Phase 3·NCT00000478

Insulin Sensitivity1 trial

The Effect of Nebivolol on Insulin Sensitivity

Completed·IImperial College London·N/A·NCT00125853·54 enrolled

Function1 trial

Elder Surgery - Functional Recovery Following Beta Blockade

Completed·IIcahn School of Medicine at Mount Sinai·Phase 4·NCT00507663·359 enrolled

ESS1 trial

Comparison of Aliskiren vs Negative Controls on Aortic Stiffness in Patients With MFS

Completed·SSamsung Medical Center·Phase 3·NCT01715207·30 enrolled

Atherosclerosis1 trial

Olmesartan Medoxomil in Atherosclerosis

Completed·SSankyo Pharma Gmbh·Phase 3·NCT00185185·165 enrolled

Blood Pressure Variability1 trial

The Effect of Nitrendipine/Atenolol Combination on Blood Pressure Variability.

Unknown status·SShanghai Jiao Tong University School of Medicine·Phase 4·NCT04931108·32 enrolled

Stress1 trial

Evaluation of The Effects of Nebivolol in Comparison to Atenolol on Wall Shear Stress and Rupture Prone Coronary Plaques

Completed·EEmory University·Phase 4·NCT01230892·29 enrolled

Thoracic Aortic Aneurysm1 trial

Captopril Versus Atenolol to Prevent Expansion Rate of Thoracic Aortic Aneurysms

Unknown status·OOnassis Cardiac Surgery Centre·N/A·NCT04224675·424 enrolled

Heart Disease1 trial

Irbesartan and Atenolol in Hypertensive Heart Disease

Completed·KKarolinska Institutet·Phase 2/3·NCT00389168·115 enrolled

Bicuspid aortic valve1 trial

Beta Blockers and Angiotensin Receptor Blockers in Bicuspid Aortic Valve Disease Aortopathy (BAV Study)

Terminated·HHamilton Health Sciences Corporation·Phase 3·NCT01202721·85 enrolled

Pregnancy1 trial

Effect of Labetalol, Atenolol, and Nifedipine on Maternal Hemodynamics Measured by ICG in Early Pregnancy

Recruiting·MMarshall University··NCT04755764·60 enrolled

Ischemic stroke1 trial

Comparison of Peripheral and Cerebral Arterial Flow in Acute Ischemic Stroke: Fimasartan vs. Valsartan vs. Atenolol

Unknown status·—·Phase 4·NCT02403349·105 enrolled

Endothelial Function1 trial

A Study Examining the Effects of Nebivolol Compared to Atenolol on Endothelial Function

Completed·UUniversity of Minnesota·Phase 2·NCT01522950·76 enrolled

Atrial Fibrillation1 trial

Genetically Determined Response to Atenolol in Patients With Persistent Atrial Fibrillation

Completed·VVanderbilt University Medical Center·N/A·NCT01719367·38 enrolled

Hemodynamic Changes1 trial

Hemodynamic Changes of Patients Receiving Atenolol/Bisoprolol

Completed·HHospital Italiano de Buenos Aires·Phase 4·NCT01939509·80 enrolled

Tolerance1 trial

Effect of Ivabradine on Heart Rate & Effort Tolerance in Mitral Stenosis in Sinus Rhythm

Completed·GGovind Ballabh Pant Hospital·Phase 3·NCT01022463·50 enrolled

Growth1 trial

Study of Glucagon, Ghrelin and Growth Hormone as Counterregulatory Hormones

Unknown status·UUniversity of Virginia·N/A·NCT01795235·6 enrolled

Angina Pectoris1 trial

Comparison of Carvedilol and Atenolol on Anti-anginal and Metabolic Effects in Patients With Stable Angina Pectoris

Completed·GGachon University Gil Medical Center·Phase 4·NCT02547597·99 enrolled

Cachexia1 trial

Multimodal Treatment Strategy for Cancer Cachexia

Terminated·MM.D. Anderson Cancer Center·N/A·NCT00625742·15 enrolled

Metabolism1 trial

Dose Response and Receptor Selectivity of Beta-blocker Effects on Bone Metabolism

Completed·MMayo Clinic·Phase 1·NCT02467400·165 enrolled

Migraine1 trial

4-Aminopyridine, Atenolol, or Placebo in Patients With Vestibular Migraine

Withdrawn·MMassachusetts Eye and Ear Infirmary·Phase 2·NCT03578354

Interaction1 trial

Phase 1 Drug Interaction Study of Apixaban and Atenolol in Healthy Subjects

Completed· Bristol-Myers Squibb logo

Bristol-Myers Squibb·Phase 1·NCT02262533·15 enrolled

Chronic Stable Angina1 trial

Study to Assess Efficacy of Nicorandil+Atenolol vs Atenolol in Treatment of Chronic Stable Angina.

Unknown status·FFerozsons Laboratories Ltd.·Phase 4·NCT01397994·40 enrolled

Microvascular Function1 trial

Effects of Amlodipine and Other Blood Pressure Lowering Agents on Microvascular Function

Terminated·LLudwig-Maximilians - University of Munich·Phase 3·NCT03082014·101 enrolled

Coronary Artery Disease1 trial

Heart Rate Control Before Cardiac Computed Tomography in Adults for the Evaluation of Coronary Artery Disease

Enrolling by invitation·GGødstrup Hospital·Phase 2/3·NCT07268170·350 enrolled

Endothelial Dysfunction1 trial

Effect of the Angiotensin II Receptor Antagonist Irbesartan on Biochemical and Functional Markers of Endothelial Dysfunction in Patients With Hypertension

Completed· Sanofi logo

Sanofi·Phase 4·NCT00529750·108 enrolled

PTSD1 trial

Role of Sympathetic Overactivity and Angiotensin II in PTSD and CV

Suspended·EEmory University·Phase 2·NCT02560805·134 enrolled

Hemodynamic Response1 trial

Hemodynamic Response of Neuropathic And Non-Neuropathic POTS Patients To Adrenoreceptor Agonist And Antagonist

Terminated·—·Phase 1/2·NCT03070730·8 enrolled

MPA1 trial

Comparison Between Atenolol,Propnalol and Ivabradine

Completed·MMenoufia University·N/A·NCT06670690·120 enrolled

Osteoporosis1 trial

Atenolol for the Prevention of Osteoporosis (APO)

Active, not recruiting·—·Phase 2·NCT04905277·420 enrolled

Single Dose1 trial

Effects of Sodium Intake on (PK/PD) Relationship of a Single Dose of a Renin Angiotensin System-Blocker

Completed·AAssistance Publique - Hôpitaux de Paris·Phase 1·NCT00310778·64 enrolled

Preeclampsia1 trial

Impedance Cardiography to Decrease the Risk of Preeclampsia

Withdrawn·UUniversity of Tennessee Medical Center·Phase 1·NCT03245970

Fasting Conditions1 trial

Bioequivalence Study of Atenolol 100mg Tablets Under Fasting Conditions

Completed·RRanbaxy Laboratories Limited·N/A·NCT00775580·36 enrolled

Tachycardia1 trial

Effect of Atenolol Versus Ivabradine on HRV in TRS Patients on Clozapine With Tachycardia: A Randomised Control Trial.

Recruiting·—·N/A·NCT06505668·40 enrolled

Obese Patients1 trial

Use of Impedance Cardiography to Decrease the Risk of Pre-eclampsia in Obese Patients

Unknown status·UUniversity of Tennessee Graduate School of Medicine·Phase 1·NCT03105661·400 enrolled

Unspecified4 trials

Perioperative Effect of Atenolol on Cytokine Profiles

Unknown status·SSaini Foundation·Phase 4·NCT00202358·60 enrolled

To Demonstrate the Relative Bioavailability of Atenolol Tablets, 100 mg

Completed· Novartis logo

Novartis·Phase 1·NCT00946725·28 enrolled

To Demonstrate the Relative Bioavailability of Atenolol Tablets

Completed· Novartis logo

Novartis·Phase 1·NCT00913965·24 enrolled

Show 1 more trial

Genetic Determinants of Response to Beta Blockade

Completed·VVanderbilt University·N/A·NCT00837902·154 enrolled

Regulatory

FDA Approval Timeline[5]

Sep 13, 1989

TENORMIN

NDA NDA019058

Apr 9, 1990

TENORMIN

NDA NDA018240

Sources

References

[1]
ClinicalTrials.gov — 71 trial records for Atenolol. U.S. National Library of Medicine, National Institutes of Health.
[2]
MedlinePlus Drug Information — Tenormin drug information. U.S. National Library of Medicine, National Institutes of Health.
[3]
ChEMBL — Atenolol compound record. European Bioinformatics Institute (EMBL-EBI).
[4]
Open Targets Platform — Drug–disease associations for Atenolol. EMBL-EBI & Wellcome Sanger Institute.
[5]
OpenFDA — FDA approval records (NDA NDA018240). U.S. Food & Drug Administration.
[6]
SEC EDGAR — Twinpig Biolab, Inc. company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Mechanism of Action: Beta-1 Adrenergic Receptor Antagonist[3]
Modality: Small molecule[3]
Highest Phase: Approved[1]
Company: TTwinpig Biolab, Inc.

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