VivoSeq
Cardiovascular

Arrhythmia

41

Pipeline Programs↗

3

Active Trials↗

18

Companies Involved↗

Arrhythmia is a moderately active landscape with 41 programs across 18 companies. The most active players are Astellas, Ono Pharmaceutical Co. Ltd, Novo Nordisk. 12 therapies are approved with 7 more in late-stage development.

Intelligence

Pipeline Metrics

Competitive Density

56/100

Pipeline Velocity

15/100

Mech. Concentration

12/100

Completion Rate

74/100

Attrition Rate

17/100

Competition

Competitive Landscape

Bubble size = clinical trials

Approved
Phase 3
Phase 2
Phase 1
Preclinical

Key Players

Top Companies Companies ranked by the number of pipeline programs they run for this disease.

Astellas logo

Astellas

1 program

Phase 3Ono Pharmaceutical Co. Ltd logo

Ono Pharmaceutical Co. Ltd

1 program

Phase 3Novo Nordisk logo

Novo Nordisk

1 program

Phase 3M

Menarini International Operations Luxembourg SA

1 program

Phase 3P

Pfizer's Upjohn has merged with Mylan to form Viatris Inc.

1 program

ApprovedA

Advanz Pharma

1 program

Approved

Pipeline

Programs by Phase

Preclinical17

Propranolol

Wyeth-Lederle Vaccines

Dexmedetomidine

McNeil Consumer & Specialty Pharmaceuticals, a Division of McNeil-PPC, Inc.

Ropivacaine

Fresenius Kabi Oncology Ltd.

Propofol

Fresenius Kabi Oncology Ltd.

Standard Medical Therapy

Post Graduate Institute of Medical Education and Research, Chandigarh

Phase 1
No programs
Phase 25

Epinephrine

Samson Clinical Operations Pty Ltd

Metoprolol

Bp Consulting, Inc

IV Atropine

Assiut University

IM Atropine

Assiut University

Atropine and Dexamethasone

Assiut University

Phase 37

Semaglutide

Novo Nordisk

Cefazolin

Baxter Healthcare Corporation

Magnesium

Spherium Biomed

Ranolazine

Menarini International Operations Luxembourg SA

Routine Care

University of California, Los Angeles

Approved12

Atorvastatin

Pfizer's Upjohn has merged with Mylan to form Viatris Inc.

Digoxin

Advanz Pharma

Colchicine

Alnylam Pharmaceuticals

Remimazolam Besylate

Union Hospital, Tongji Medical College, Huazhong University of Science and Technology

Lovaza

AstraZeneca

Analysis

Modality Breakdown

98%

Small molecule

42 of 43 classified programs — the dominant modality here.

2%ALL OTHERSPeptide12%

Small molecule leads; the ring shows all 43 classified programs, each share of the total. Modality classified for 100% of 44 pipeline programs.

Analysis

Trial Status

35

clinical trials

Completed20 · 57%
Terminated5 · 14%
Unknown status5 · 14%
Not yet recruiting3 · 9%
Withdrawn1 · 3%
Suspended1 · 3%

Clinical Trials

Trial Activity

35 trials

Arrhythmia Cohort Study
Not yet recruiting·—·N/A·NCT07123896·10,000 enrolled
Acupuncture for Preventing Atrial Arrhythmia Recurrence After Ablation
Not yet recruiting·SShanghai Zhongshan Hospital·N/A·NCT07487532·120 enrolled
A Study on the Acquisition of 2D ICE Images With the CHORUS IDx System in Subjects Undergoing an Ablation Procedure
Not yet recruiting·BBoston Scientific Corporation·Preclinical·NCT07353710·200 enrolled
Effect of Sedative Agent on Reducing the Frequency of Arrhythmia in the Patients After Cardiac Surgery
Completed·AAnesthesia Research Group UA·N/A·NCT05450497·356 enrolled
Response to RSD1235 Compared to Placebo in Subjects With Atrial Arrhythmia After Heart Surgery
Completed·Astellas logoAstellas·Phase 3·NCT00125320·190 enrolled
Study of Arrhythmia and ECG Abnormalities in Patients With COVID-19
Completed·UUniversity Hospital, Bordeaux·N/A·NCT04937621·196 enrolled
Modeling of Amiodarone Effect on Heart Rate Control in Critically Ill Patients With Atrial Tachyarrhythmias
Completed·GGroupe Hospitalier Pitie-Salpetriere·N/A·NCT03413150·80 enrolled
The HOLIDAY (HOw ALcohol InDuces Atrial TachYarrhythmias) Study
Completed·UUniversity of California, San Francisco·N/A·NCT01996943·100 enrolled
Controlled Study of ONO-1101 in Patients With Postoperative Tachyarrhythmias in Japan
Completed·OOno Pharma USA Inc·Phase 2·NCT00212680·100 enrolled
The Personalized Chinese Herb Formulas Over Hypertensive Bradyarrhythmia
Completed·—·N/A·NCT04505228·72 enrolled
Brad Arrhythmia Induced by Repeated Succinylcholine During Gynecological Laparoscopic Surgery
Completed·—·Phase 2·NCT02676011·120 enrolled
Amiodarone to Prevent Post-Operative Arrhythmias
Completed·UUniversity of Calgary·Phase 3·NCT00251706·600 enrolled
Prevention of Arrhythmia Device Infection Trial (PADIT)
Completed·PPopulation Health Research Institute·Phase 4·NCT01628666·12,814 enrolled
Glycopyrrolate Prophylaxis for Prevention of Bradyarrhythmia During Laparoscopic Cholecystectomy
Completed·NNational Academy of Medical Sciences, Nepal·N/A·NCT05997004·62 enrolled
Reversal of Neuromuscular Blockade and Perioperative Arrhythmias
Completed·—·N/A·NCT04720573·80 enrolled
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Data sources: ClinicalTrials.gov (NIH) · OpenFDA (FDA) · ChEMBL (EMBL-EBI) · Open Targets (EBI/Sanger) · MedlinePlus (NIH) · PubMed (NIH) · SEC EDGAR (SEC)