Infectious Disease

Bronchiolitis

38

Pipeline Programs↗

6

Active Trials↗

17

Companies Involved↗

Bronchiolitis is a moderately active landscape with 38 programs across 17 companies. The most active players are Hyundai Pharmaceutical Co., LTD., Validus Pharmaceuticals, Exela Pharma Sciences, LLC.. 5 therapies are approved with 12 more in late-stage development.

Intelligence

Pipeline Metrics

Competitive Density

56/100

Pipeline Velocity

11/100

Mech. Concentration

28/100

Completion Rate

76/100

Attrition Rate

18/100

Competition

Competitive Landscape

Bubble size = clinical trials

Approved

Phase 3

Phase 2

Phase 1

Preclinical

Key Players

Top Companies

Hyundai Pharmaceutical Co., LTD.

1 program

Validus Pharmaceuticals

1 program

Exela Pharma Sciences, LLC.

1 program

Fresenius Kabi Oncology Ltd.

1 program

CSL Behring

1 program

GSK

2 programs

Pipeline

Programs by Phase

Preclinical10

Montelukast

Organon and Co

Methylprednisolone

Pfizer

Epinephrine

Samson Clinical Operations Pty Ltd

Prednisolone

Pfizer's Upjohn has merged with Mylan to form Viatris Inc.

Salbutamol

GSK

Phase 1

No programs

Phase 211

Cholecalciferol

Hyundai Pharmaceutical Co., LTD.

Furosemide

Validus Pharmaceuticals

Phenylephrine

Exela Pharma Sciences, LLC.

Magnesium Sulfate

Fresenius Kabi Oncology Ltd.

Fluticasone Propionate

GSK

Phase 312

Montelukast Sodium

AstraZeneca

Zinc Sulfate

Fakultas Kedokteran Universitas Indonesia

Nitric Oxide

Mallinckrodt

Betamethasone

Schering-Plough

Clarithromycin

AbbVie

Approved5

Dexamethasone

Aspen Global Incorporated

Erythromycin

Azurity Pharmaceuticals

Albuterol Plus Tiotropium

IRCCS Azienda Ospedaliera Universitaria San Martino - IST Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy

Racemic Adrenaline

Oslo University Hospital

N-Acetyl Cyteien

Stanford University

Analysis

Modality Breakdown

98%

Small molecule

53 of 54 classified programs — the dominant modality here.

Small molecule leads; the ring shows all 54 classified programs, each share of the total. Modality classified for 100% of 55 pipeline programs.

Analysis

Trial Status

68

clinical trials

Completed42 · 62%

Terminated9 · 13%

Unknown status7 · 10%

Recruiting3 · 4%

Withdrawn3 · 4%

Active, not recruiting2 · 3%

Other2 · 3%

Clinical Trials

Trial Activity

68 trials

Peginterferon α-2b Injection for the Treatment of Pediatric RSV Bronchiolitis

Recruiting·—·N/A·NCT06827249·90 enrolled

Efficacy of Lavender Essential Oil Chest Wraps in Infants With Bronchiolitis

Recruiting·UUniversity Hospital, Geneva·Phase 4·NCT06108648·400 enrolled

Characterization of Bronchodilator Response in Children With Bronchiolitis Using Phenotypic and Genotypic Features

Recruiting·NNemours Children's Clinic·Phase 3·NCT06946264·400 enrolled

Efficacy of Magnesium Sulfate Bolus in Pediatric Patients With Bronchiolitis

Active, not recruiting·UUniversity of Louisville·Phase 2/3·NCT04740294·40 enrolled

The Role of Vitamin D and Vitamin D Receptor in Recurrent Wheezing in Children With Bronchiolitis: Immunological Association With T-lymphocyte Mitochondrial Mass

Active, not recruiting·NNational and Kapodistrian University of Athens·N/A·NCT07700134·130 enrolled

Impact of Outpatient Respiratory Physiotherapy on Hospitalizations and Costs in Infants With Acute Viral Bronchiolitis: A Quasi-Experimental Study in Public Health Services in Sorocaba.

Not yet recruiting·UUniversity of Sao Paulo·Preclinical·NCT07682844·1,000 enrolled

Montelukast in Acute RSV Bronchiolitis

Completed·ZZiv Hospital·N/A·NCT00524693·51 enrolled

Bronchodilator Responsiveness in Obliterative Bronchiolitis

Completed·IIRCCS Azienda Ospedaliera Universitaria San Martino - IST Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy·Phase 4·NCT01112241·17 enrolled

Nebulized 3% Hypertonic Saline Solution Treatment of Bronchiolitis in Infants

Completed·CCoordinación de Investigación en Salud, Mexico·Phase 4·NCT02233985·64 enrolled

Efficacy of Zinc in the Treatment of Bronchiolitis and Prevention of Wheezing Respiratory Illness in Children Less Than Two Years Old

Completed·IInternational Centre for Diarrhoeal Disease Research, Bangladesh·Phase 3·NCT00355043·330 enrolled

Efficacy of Magnesium Sulfate in the Treatment of Bronchiolitis

Completed·HHamad Medical Corporation·Phase 2·NCT02145520·200 enrolled

Use of Erythromycin in Mustard-Induced Bronchiolitis

Completed·—·Phase 4·NCT00367419

Nebulized 5% Hypertonic Saline for the Treatment of Bronchiolitis

Completed·HHamad Medical Corporation·Phase 4·NCT01016249·187 enrolled

A Study of Hypertonic Saline for Infants Hospitalized With Bronchiolitis

Completed·MMontefiore Medical Center·N/A·NCT01488448·227 enrolled

Caffeine Citrate for the Treatment of Apnea Associated With Bronchiolitis in Young Infants

Completed·HHamad Medical Corporation·N/A·NCT01435486·90 enrolled

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Data sources: ClinicalTrials.gov (NIH) · OpenFDA (FDA) · ChEMBL (EMBL-EBI) · Open Targets (EBI/Sanger) · MedlinePlus (NIH) · PubMed (NIH) · SEC EDGAR (SEC)