Liposomal bupivacaine

Phase 3Small molecule

Liposomal bupivacaine is one of 141 small molecule programs targeting Total Knee Arthroplasty. It is currently in Phase 3.

Indications

162

Total Trials

Active Trials

140

Competitors

Pipeline

Status by Indication[3][1]

Indication

Total Knee ArthroplastyRecruiting

Liposomal BupivacaineCompleted

Total Joint ArthroplastyActive, not recruiting

Liposome BupivacaineNot yet recruiting

Liver and Intrahepatic Bile Duct DisorderActive, not recruiting

Diaphragmatic FunctionRecruiting

Local InfiltrationTerminated

Video-Assisted Thoracoscopic SurgeryNot yet recruiting

Local AnestheticActive, not recruiting

Chronic PainRecruiting

Total Knee ArthroplastyPhase 3

Recruiting

Liposomal BupivacainePhase 3

Completed

Total Joint ArthroplastyPreclinical

Active, not recruiting

Liposome BupivacainePreclinical

Not yet recruiting

Liver and Intrahepatic Bile Duct DisorderPhase 3

Active, not recruiting

Diaphragmatic FunctionPreclinical

Recruiting

Local InfiltrationPreclinical

Terminated

Video-Assisted Thoracoscopic SurgeryPhase 3

Not yet recruiting

Local AnestheticPhase 2

Active, not recruiting

Chronic PainPhase 3

Recruiting

Showing 10 of 16 indications

Competition

Competitive Landscape

77 competitors in Chronic Pain

#DrugCompanyPhaseTrials

Voltaren

Novartis

Approved

1 2

Duragesic

CCephalon

Approved

4 3

MS Contin

HHikma Pharmaceuticals LLC

Approved

4 4

Dolophine

HHikma Pharmaceuticals LLC

Approved

3 5

Precedex

MMcNeil Consumer & Specialty Pharmaceuticals, a Division of McNeil-PPC, Inc.

Approved

2 6

Tylenol

KKenvue Brands

Approved

1 7

Marcaine

IInnocoll

Approved

1 8

Decadron

AAspen Global Incorporated

Approved

1 9

Prilosec

DDexcel Pharma Technologies Ltd.

Lodosyn

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q4 2026

Post-ApprovalNot yet recruiting

Liposomal Bupivacaine

NCT04003506

Phase 3Recruiting

Liposomal Bupivacaine

NCT06179004

Post-ApprovalRecruiting

Liposomal Bupivacaine

NCT05972018

Phase 2Active, not recruiting

Retroperitoneal Sarcoma

NCT04189783

Q1 2027

PreclinicalNot yet recruiting

Liposome Bupivacaine

NCT07667439

Q2 2027

Active, not recruiting

Mastectomy

NCT05795413

Clinical

Trials by Indication[1]

Liposomal Bupivacaine61 trials

Liposomal Bupivacaine Interscalene Nerve Block in Shoulder Arthroplasty

Completed·MMayo Clinic·Phase 4·NCT03663283·104 enrolled

Liposomal Bupivacaine After Arthroscopic Rotator Cuff Repair

Completed·SSteven Orebaugh·Phase 4·NCT03149887·54 enrolled

Pec Infiltration With Liposomal Bupivacaine for Breast Surgery

Completed·UUniversity of Minnesota·Phase 4·NCT03599635·112 enrolled

Show 58 more trials

Analgesic Efficacy of Liposomal Bupivacaine vs. Bupivacaine HCL as a Tap Block After Abdominally Based Autologous Breast Reconstruction

Terminated·WWashington University School of Medicine·Phase 4·NCT02662036·70 enrolled

Transversus Abdominis Plane (TAP) Block Using Liposomal Bupivacaine in Metabolic and Bariatric Surgery Patients

Completed·WWake Forest University Health Sciences·Phase 1·NCT05537883·72 enrolled

Liposomal Bupivacaine Interscalene Blocks for Rotator Cuff Repair

Completed·UUniversity of Minnesota·Phase 4·NCT03587584·80 enrolled

Liposomal Bupivacaine for Pain Control Following Thoracic Surgery.

Unknown status·MMassachusetts General Hospital·Phase 2/3·NCT03036085·200 enrolled

Liposomal Bupivacaine in Implant Based Breast Reconstruction

Terminated·LLoma Linda University·N/A·NCT02659501·24 enrolled

Intraoperative Liposomal Bupivacaine vs. Bupivacaine for Total Hip Replacement Pain Management

Completed·AAmerican Hip Institute·Phase 2·NCT03001453·107 enrolled

Liposomal Bupivacaine To Control Post-Operative Pain Following BMG

Completed·UUrology of Virginia·Phase 3·NCT03720223·50 enrolled

Impact of Liposomal Bupivacaine Administered Following Placement of a Transobturator Suburethral Sling

Terminated·TTriHealth Inc.·Phase 4·NCT02591888·18 enrolled

Effectiveness of Adductor Canal Block Using Liposomal Bupivacaine

Not yet recruiting·TThe University of Hong Kong·Phase 4·NCT04003506·90 enrolled

Liposomal Bupivacaine Versus Lidocaine for Skin Graft Donor Site Pain

Recruiting·UUniversity of Kansas Medical Center·Phase 4·NCT03854344·75 enrolled

Sternal Block With Liposomal Bupivacaine vs. Saline Prior to Incision in Cardiac Surgery

Completed·—·Phase 4·NCT04333095·70 enrolled

Comparing Liposomal Bupivacaine Versus Standard Bupivacaine in Colorectal Surgery

Completed·IIndiana University·Phase 3·NCT03702621·90 enrolled

Liposomal Bupivacaine Versus Bupivacaine Plain for Operative Pain Management of Forefoot Surgery

Unknown status·AAlexandra Black·Phase 4·NCT04751344·100 enrolled

Thoracic Epidural Analgesia vs Surgical Site Infiltration With Liposomal Bupivacaine Following Open Gynecologic Surgery

Completed·SSidney Kimmel Comprehensive Cancer Center at Johns Hopkins·Phase 3·NCT04117074·106 enrolled

Trial of Liposomal Bupivacaine for TKA

Completed·—·Phase 4·NCT05635916·80 enrolled

Rectus Sheath Block With Liposomal Bupivacaine Versus Thoracic Epidural Analgesia for Pain Control Following Pancreatoduodenectomy

Recruiting·MMasonic Cancer Center, University of Minnesota·Phase 2·NCT06411795·78 enrolled

TAP Block Using Liposomal Bupivacaine for Post-cesarean Delivery Analgesia- Walking Towards Recovery

Terminated·YYale University·Phase 4·NCT04393207·147 enrolled

Liposomal Bupivacaine for Pain Control After Rotator Cuff Repair

Completed·OOrthopaedic & Neurosurgery Specialists·N/A·NCT03692546·50 enrolled

The Efficacy of Liposomal Bupivacaine in Ultrasound Guided Supraclavicular Nerve Blocks for Hand and Wrist Surgery

Active, not recruiting·SSt. Luke's Hospital, Pennsylvania·Phase 4·NCT06806410·120 enrolled

Liposomal Bupivacaine vs Ropivacaine for TAPBs

Recruiting·SSun Yat-sen University·Phase 3·NCT06430112·74 enrolled

Enhanced Recovery With Liposomal Bupivacaine in Orthognathic Surgery

Unknown status·UUniversity of Texas at Austin·Phase 4·NCT03844451·75 enrolled

Wound Infiltration of Liposomal Bupivacaine v Plain Bupivacaine for Post-Op Pain Control in Elective Cesarean Delivery

Unknown status·—·Phase 4·NCT03353363·132 enrolled

Liposomal Bupivacaine Versus Standard of Care in Total Knee Surgery

Completed·OOhioHealth·N/A·NCT02219087·60 enrolled

Efficacy of Liposomal Bupivacaine Post Septorhinoplasty

Enrolling by invitation·JJessyka Lighthall·Phase 3·NCT05964868·72 enrolled

Bupivacaine Versus Liposomal Bupivacaine For Breast Pain Management After Breast Recontruction

Withdrawn·—·Phase 2·NCT03393117

Liposomal Bupivacaine vs. Bupivacaine Hydrochloride and Lidocaine During Suburethral Sling Placement

Completed·—·N/A·NCT02875015·57 enrolled

Liposomal Bupivacaine Use in Alveolar Bone Graft Patients

Recruiting·KKerry O'Rourke·Phase 3·NCT06284434·60 enrolled

Supraclavicular Bupivacaine Vs. Supraclavicular Liposomal Bupivacaine for Orthopedic Wrist Surgery

Recruiting·UUniversity of North Carolina, Chapel Hill·Phase 3·NCT06179004·100 enrolled

Obstetric Liposomal Bupivacaine Via Surgical Transversus Abdominis Plane Block for Post Cesarean Pain Control

Completed·UUniversity of Wisconsin, Madison·Phase 4·NCT04897841·60 enrolled

TAP Block With Liposomal Bupivacaine Versus Pre-incisional Wound Infiltration With Bupivacaine for Postoperative Pain

Terminated·UUniversity of Tennessee·Phase 1·NCT02400645·69 enrolled

Liposomal Bupivacaine at Cesarean Delivery to Decrease Post-operative Pain

Completed·MMassachusetts General Hospital·Phase 2/3·NCT02959996·80 enrolled

Subcostal TAP Block With Liposomal Bupivacaine Versus Bupivacaine in Donor Nephrectomy Patients: A Prospective Study

Completed·UUniversity of Minnesota·Phase 4·NCT02287623·60 enrolled

Efficacy of Liposomal Bupivacaine Versus 0.25% Bupivacaine for Laparoscopic Urologic Surgery

Completed·—·Phase 4·NCT02222129·206 enrolled

Intercostal Liposomal Bupivacaine for the Management of Blunt Chest Wall Trauma

Completed·UUniversity of Cincinnati·Phase 2·NCT02749968·100 enrolled

Liposomal Bupivacaine With or Without Hydromorphone for the Improvement of Pain Control After Laparotomy in Patients With Gynecological Malignancies

Completed·MMayo Clinic·Phase 4·NCT04258631·105 enrolled

Pharmacokinetics of Single-Dose Liposomal Bupivacaine in Surgeon Performed Intercostal Nerve Blocks

Completed·UUniversity of Virginia·Phase 4·NCT03708198·15 enrolled

Liposomal Bupivacaine/Bupivacaine in Rectus Sheath Blocks Versus Ropivacaine in Rectus Sheath Blocks And Catheters

Recruiting·HHartford Hospital·Phase 4·NCT05972018·14 enrolled

Liposomal Bupivacaine in Benign Soft Tissue Tumor Resection

Unknown status·SSamaritan Health Services·Phase 4·NCT05082441·140 enrolled

Liposomal Bupivacaine in Adductor Canal Blocks (ACB)

Withdrawn·UUniversity of Miami·Phase 4·NCT04539730

The Use Of Liposomal Bupivacaine For Pain Control

Completed·WWake Forest University Health Sciences·Phase 4·NCT03722927·3 enrolled

Liposomal Bupivacaine (Exparel) in Sarcomas

Terminated·WWake Forest University Health Sciences·Phase 1·NCT03867188·2 enrolled

Liposomal Bupivacaine + Bupivacaine vs. Bupivacaine Alone on Opioid Use After Elective c/Section

Withdrawn·WWake Forest University Health Sciences·Phase 4·NCT04232306

Comparison of Analgesic Efficacy Between of Interscalene Block With Liposomal Bupivacaine With Bupivacaine and Dexamethasone

Completed·IIcahn School of Medicine at Mount Sinai··NCT03969875·90 enrolled

A Study of Liposomal Bupivacaine Versus 0.25% Bupivacaine Hydrochloride Post Breast Reduction

Completed·MMayo Clinic·Phase 4·NCT05891613·32 enrolled

Pudendal Block Using Liposomal Bupivacaine vs. Standard Treatment During Sacrospinous Ligament Fixation

Unknown status·—·Phase 4·NCT03664986·88 enrolled

Wound Infiltration With Liposomal Bupivacaine vs. Standard Wound Infiltration With Bupivacaine in Patient's Undergoing Open Gynecologic Surgery on an Enhanced Recovery Pathway

Terminated·MM.D. Anderson Cancer Center·Phase 3·NCT02740114·105 enrolled

Evaluation of Liposomal Bupivacaine Compared to Usual Care and Its Effects on Pain for Cardiac Surgery

Unknown status·FFlorida Heart and Lung Institute·Phase 4·NCT04065919·300 enrolled

Liposomal Bupivacaine in Shoulder Arthroscopy

Withdrawn·UUniversity of Pennsylvania·Phase 3·NCT04461028

Pilot Study of Liposomal Bupivacaine Redosing in Patients Undergoing Major Gynecologic Procedures

Terminated·UUniversity of California, Irvine·Phase 3·NCT04849858·13 enrolled

Post-operative Pain Control of Testicular Sperm Extraction Using Liposomal Bupivacaine

Completed·WWeill Medical College of Cornell University·Phase 4·NCT03802864·50 enrolled

Intraoperative TAP Block With Bupivacaine/Dexamethasone Against Liposomal Bupivacaine (Exparel®)

Completed·—·Phase 4·NCT03723447·102 enrolled

Liposomal Bupivacaine and Transoral Robotic Surgery

Recruiting·GGeisinger Clinic··NCT05862792·80 enrolled

Continuous vs Liposomal Bupivacaine Interscalene Block for Proximal Humeral Fracture (CLIP)

Unknown status·TThe University of Hong Kong·Phase 4·NCT04928664·78 enrolled

Thoracic Epidural Analgesia Versus Rectus Sheath Block Versus Surgeon Infiltration With Liposomal Bupivacaine or Standard Bupivacaine for Post-Operative Pain Control After Cystectomy

Completed·IIndiana University·Phase 3·NCT04300231·160 enrolled

Interscalene Block With and Without Liposomal Bupivacaine in Shoulder Surgery

Completed·OOrthopaedic & Neurosurgery Specialists·N/A·NCT03728946·100 enrolled

Interscalene Block With Liposomal Bupivacaine vs. Interscalene Block With Bupivacaine and Adjuvants

Terminated·WWake Forest University Health Sciences·Phase 4·NCT03845894·25 enrolled

Does a ThoracoLumbar Interfacial Plane (TLIP) Block With Liposomal Bupivacaine Provide TLIP Block in Spinal Surgery

Unknown status·TThe Cooper Health System·Phase 2·NCT04865211·90 enrolled

Liposomal Bupivacaine Versus Ropivacaine for Preperitoneal Infiltration Analgesia in Upper Abdominal Laparotomy: A Randomized Controlled Trial

Completed·QQilu Hospital of Shandong University·Preclinical·NCT07271979·146 enrolled

Total Shoulder Arthroplasty7 trials

Postoperative Pain Control in Total Shoulder Arthroplasty

Completed·SScripps Clinic·Phase 4·NCT05068960·100 enrolled

Liposomal Bupivacaine in Total Shoulder Arthroplasty

Completed·HHenry Ford Health System·Phase 4·NCT02570022·57 enrolled

Liposomal Bupivacaine (Exparel ® ) Plus 0.5% Bupivacaine HCL Versus 0.5% Bupivacaine HCL for Interscalene Nerve Block (ISB) for Patients Undergoing Total Shoulder Arthroplasty(TSA)

Completed·NNYU Langone Health·Phase 4·NCT03913091·184 enrolled

Show 4 more trials

Liposomal Bupivacaine for Pain Control After Total Shoulder Arthroplasty

Completed·JJohns Hopkins University·N/A·NCT02762071·108 enrolled

Pain Management After Total Shoulder Arthroplasty

Terminated·TThe Christ Hospital·Phase 4·NCT03219983·22 enrolled

Liposomal Bupivacaine Versus Non-liposomal Bupivacaine for Total Shoulder Arthroplasty

Completed·UUniversity of Virginia·Phase 3·NCT04974385·80 enrolled

A Double-Blind Randomized Comparison Trial of Postoperative Pain in Patients Undergoing Total Shoulder Arthroplasty Who Receive Interscalene Blocks With or Without Liposomal Bupivacaine (PoPTSAWoW Trial)

Terminated·JJohnny K. Lee·Approved·NCT05900427·78 enrolled

Hysterectomy6 trials

Randomized Trial of Wound Infiltration With Extended-release Bupivacaine Before Laparoscopic or Robotic Hysterectomy

Completed·AAdventHealth·Phase 4·NCT02352922·64 enrolled

TAP vs Surgical Infiltration of Local Anesthetic in Laparoscopic and Robotic Hysterectomy

Completed·UUniversity of Minnesota·Phase 4·NCT02519023·87 enrolled

TAP Block With Liposomal Bupivacaine Versus Bupivacaine in Robotic Hysterectomy

Completed·UUniversity of Minnesota·Phase 4·NCT02289079·60 enrolled

Show 3 more trials

Mixture of Liposomal Bupivacaine and Bupivacaine for TAP Block for Open Hysterectomy

Completed·HHenry Ford Health System·Phase 4·NCT03250507·90 enrolled

ESP Block VS TAP in Laparoscopic Hysterectomy

Completed·IIndiana University·Phase 3·NCT04003987·78 enrolled

Liposomal Bupivacaine in Vaginal Hysterectomy

Terminated·MMayo Clinic·Phase 4·NCT03907033·28 enrolled

Total Knee Arthroplasty6 trials

Efficacy and Safety of Liposomal Bupivacaine Using Periarticular Injection in Total Knee Arthroplasty

Recruiting·—·Phase 4·NCT06557018·60 enrolled

Liposomal Bupivacaine vs Adductor Canal Block in Total Knee Arthroplasty

Completed·TTexas Orthopaedics, Sports and Rehabilitation Associates·Phase 4·NCT02863120·63 enrolled

Liposomal Bupivacaine Versus Standard Bupivacaine Plus Dexamethasone in Quadriceps Sparing Femoral Nerve Block and Wound Infiltration for Total Knee Arthroplasty

Withdrawn·—·Phase 4·NCT02624856

Show 3 more trials

Liposomal Bupivacaine in Simultaneous Bilateral Total Knee Arthroplasty

Completed·OOrthoCarolina Research Institute, Inc.·Phase 4·NCT02349542·20 enrolled

A Comparison of Exparel Local Anesthetic in Total Knee Arthroplasty (TKA) Patients

Withdrawn·HHoly Cross Hospital, Florida·Phase 4·NCT02765815

Liposomal Bupivacaine in Total Knee Arthroplasty

Withdrawn·MMiller Orthopedic Specialists·Phase 4·NCT02426164

Nerve Block3 trials

Clinical Observation of Bupivacaine Liposome for Lower Extremity Nerve Block

Not yet recruiting·—·Phase 2·NCT07366905·60 enrolled

Exparel as a Nerve Block for Severe Hand Pain

Terminated·JJose Soberon, MD·Phase 2/3·NCT02374320·13 enrolled

Measuring Opioid Use After Rotator Cuff Repair: Comparing the Effects of Standard vs. Extended-release Nerve Blocks

Completed·CCarilion Clinic·Phase 4·NCT05482113·17 enrolled

66 more indications

Video-Assisted Thoracoscopic Surgery2 trials

Video-assisted Thoracoscopic Surgery - Exparel Study

Completed·NNada Sadek·Phase 2·NCT04864210·176 enrolled

Comparison of the Ultrasound-guided Paravertebral Nerve Block With Liposomal Bupivacaine Versus Ropivacaine for Post-Surgical Pain After Video-Assisted Thoracoscopic Surgery

Not yet recruiting·FFeng Gao·Phase 3·NCT06405724·84 enrolled

Mastectomy2 trials

Post-Mastectomy Analgesia Using Exparel (Liposomal) Versus Standard Bupivacaine or Placebo

Unknown status·GGeorgetown University·Phase 2·NCT03504865·100 enrolled

Quality of Recovery From Mastectomy With and Without PECS Blocks

Active, not recruiting·EEndeavor Health··NCT05795413·800 enrolled

Peripheral Nerve Block2 trials

Liposomal Bupivacaine vs Peripheral Nerve Block

Terminated·GGeisinger Clinic·Phase 4·NCT03922620·1 enrolled

Liposomal Bupivacaine Plus Bupivacaine Peripheral Nerve Blockade Versus Ropivacaine Plus Dexamethasone Peripheral Nerve Blockade for Arthroscopic Rotator Cuff Repair

Completed·—·Phase 4·NCT04737980·92 enrolled

Postoperative Analgesia2 trials

Postoperative Analgesia Between Paravertebral Block and Epidural Block in Esophageal Surgery

Recruiting·ZZhejiang Cancer Hospital·N/A·NCT06704698·132 enrolled

Postoperative Analgesia With Liposomal Bupivacaine Versus Standard Bupivacaine Combined With Dexamethasone

Completed·ZZhejiang Cancer Hospital·Phase 4·NCT06173466·96 enrolled

Erector Spinae Block2 trials

Erector Spinae Block Versus Surgeon Infiltration in VATS Procedures

Completed·IIndiana University·Phase 3·NCT03859635·120 enrolled

Erector Spinae Block for Spine Surgery

Terminated·IIcahn School of Medicine at Mount Sinai·Phase 4·NCT05417113·13 enrolled

Adductor Canal Block2 trials

Post Operative Pain Management Through Adductor Canal Block With Bupivacaine for ACL Reconstruction

Unknown status·RRothman Institute Orthopaedics·Phase 3·NCT05161221·154 enrolled

Observation Study of the Pharmacokinetics of Adductor Canal Block

Completed·TThe University of Hong Kong··NCT04916392·10 enrolled

Local Anesthetic2 trials

EXPAREL or Lidocane as Local Anesthetic in Patients Undergoing Pleuroscopy With Pleural Biopsy and Indwelling Pleural Catheter Placement

Active, not recruiting·MM.D. Anderson Cancer Center·Phase 2·NCT05044468·80 enrolled

Extended Release Local Anesthetic for Postsurgical Pain After Posterior Colporrhaphy and Perineorrhaphy

Completed·WWake Forest University Health Sciences·Phase 4·NCT03875664·72 enrolled

Abdominoplasty2 trials

Exparel vs. Standard Bupivicaine for Abdominoplasty

Terminated·EEmory University·Phase 4·NCT01853176·4 enrolled

Optimizing Recovery in Abdominoplasty

Terminated·UUniversity of Wisconsin, Madison·Phase 4·NCT04254692·2 enrolled

Amputation2 trials

Use of Long-acting Bupivacaine In Lower Extremity Amputation

Terminated·LLoma Linda University·Phase 4·NCT04360421·7 enrolled

Liposomal Bupivacaine vs Continuous Nerve Catheters for Below the Knee Amputations

Terminated·AAurora Quaye·Phase 4·NCT05140499·11 enrolled

Post Operative Pain2 trials

A Phase 3, Randomized, Double-blind, Comparator- and Placebo-controlled Study to Evaluate the Safety and Efficacy of TLC590 for Postsurgical Pain Management Following Bunionectomy

Active, not recruiting·TTLC Biopharmaceuticals, Inc.·Phase 3·NCT07222748·304 enrolled

Effect of Liposomal Bupivacaine TAPB Combined With Oxycodone PCIA on Postoperative Gastrointestinal Function in Patients Undergoing Major Abdominal Surgery: A Randomized Controlled Trial

Recruiting·TTianjin First Central Hospital·Preclinical·NCT07651722·132 enrolled

Total Joint Arthroplasty1 trial

Liposomal Bupivacaine Versus Standard Analgesia in Total Joint Arthroplasty (TJA)

Completed·OOhioHealth·N/A·NCT02197273·211 enrolled

Spine Fusion1 trial

Utility of Exparel Based ESP Blocks in Elective Posterior Spine Fusion

Unknown status·HHartford Hospital·Phase 4·NCT06107660·100 enrolled

Postoperative Pain Relief1 trial

Double-Blinded Randomized Controlled Study Investigating the Efficacy of Exparel (Liposomal Bupivacaine) for Postoperative Pain Relief in Mandibular Third Molar Extractions

Completed·UUniversity of Southern California·Phase 4·NCT05374499·73 enrolled

Gynecologic Surgery1 trial

A Comparison of Exparel to Bupivacaine in TAP Block for Abdominal Gynecologic Surgery

Unknown status·—·Phase 3·NCT03304444·128 enrolled

Retroperitoneal Sarcoma1 trial

Repeat or Single Quadratus Lumborum Block for the Reduction of Opioid Prescriptions After Surgery in Retroperitoneal Sarcoma Patients ("RESQU-SARC" Trial)

Active, not recruiting·MM.D. Anderson Cancer Center·Phase 2·NCT04189783·113 enrolled

Dexamethasone1 trial

Exparel v Dexamethasone in RCR

Enrolling by invitation·RRothman Institute Orthopaedics·Phase 4·NCT06575010·126 enrolled

Pain Control1 trial

Hip Arthroscopy Pain Control Randomized Control Trial (RCT)

Completed·WWalter Reed National Military Medical Center·Phase 4·NCT02947178·74 enrolled

Erector Spinae Plane Block1 trial

Liposomal Bupivacaine Vs Bupivacaine with Dexmedetomidine in Erector Spinae Plane Blocks for Mastectomies

Recruiting·UUnited States Naval Medical Center, Portsmouth·Phase 4·NCT06252662·200 enrolled

Bupivacaine1 trial

Comparing TAP Blocks Bupivacaine, and Placebo for Plane

Completed·EEdward Mascha·Phase 3·NCT04685876·285 enrolled

Knee Arthroplasty1 trial

A Clinical Trial of Two Periarticular Multimodal Drug Injections in Total Hip and Knee Arthroplasty

Completed·KKootenai Health·Phase 4·NCT02543801·239 enrolled

ACL Reconstruction1 trial

Evaluation of Exparel Adductor Canal Field Block for Pain Control After ACL Reconstruction

Unknown status·CCarilion Clinic·Phase 3·NCT04764916·60 enrolled

Spinal Fusion1 trial

Liposomal Bupivacaine in One-level Instrumented Posterior Spinal Fusion

Suspended·—·Phase 4·NCT03745040·60 enrolled

Anesthesia1 trial

Cranial Blocks for Postoperative Anesthesia

Terminated·UUniversity of Pennsylvania·Phase 4·NCT04749797·11 enrolled

Rib Fracture1 trial

Trial of Injected Liposomal Bupivacaine vs Bupivacaine Infusion After Surgical Stabilization of Rib Fractures

Completed·—·Phase 4·NCT03305666·36 enrolled

CAR1 trial

Multimodal Orthognathic Study Comparing Use of Exparel With Standard of Care.

Completed·UUnited States Naval Medical Center, San Diego·Phase 1·NCT06499181·86 enrolled

Humerus Fracture1 trial

Continuous Interscalene Block vs Liposomal Bupivacaine After Proximal Humerus Fracture Surgery

Unknown status·TThe University of Hong Kong·Phase 3·NCT05084573·92 enrolled

Local Infiltration1 trial

Ultrasound Guided Local Infiltration Analgesia for Hip Arthroscopy

Terminated·TTrinity Health Of New England·N/A·NCT01907191·23 enrolled

GAN1 trial

Temporary Celiac Ganglion Block as a Test Before Celiac Ganglion Resection for Dysautonomia-Related Bowel Dysmotility

Completed·JJohns Hopkins University·Phase 1·NCT04121338·15 enrolled

Lung Cancer1 trial

Pain After Lung Cancer Surgery - Comparing Traditional Versus Prolonged Release Nerve Blockades

Unknown status·JJannie Bisgaard Stæhr·Phase 2·NCT05038007·50 enrolled

Interscalene Block1 trial

Evaluation of Diaphragm Movement After an Interscalene Block

Completed·UUniversity of Minnesota·Phase 4·NCT03636542·26 enrolled

Pecto-intercostal Fascial Plane Block1 trial

Pecto-Intercostal Fascial Plane Block Study

Completed·UUniversity of Wisconsin, Madison·Phase 4·NCT04928339·100 enrolled

Hypospadias1 trial

Liposomal Bupivacaine vs Standard Penile Block for Hypospadias Repair

Withdrawn·UUniversity of Texas Southwestern Medical Center·Phase 1·NCT04479371

Thoracic Surgery1 trial

Minimally Invasive Thoracic Surgery Intercostal Nerve Block Trial

Completed·UUniversity of California, San Francisco·Phase 3·NCT03508830·91 enrolled

Thoracoscopic Lobectomy1 trial

Exparel and Marcaine for Pain Management in Thoracoscopic Lobectomy Patients

Completed·SSouthern Illinois University·Phase 3·NCT03682224·57 enrolled

Breast Reconstruction1 trial

Comparing Local Anesthetics for TAP Block During Abdominally-based Free Flap for Breast Reconstruction

Completed·VVanderbilt University Medical Center·Phase 4·NCT03700970·60 enrolled

Pain Management1 trial

A Randomized Trial of Exparel vs Saline in Opioid Reduction of Pain Management Following Lumbar Spine Surgeries.

Completed·UUniversity of Missouri-Columbia·Phase 4·NCT04644796·34 enrolled

Interscalene Brachial Plexus Block1 trial

Efficacy of Interscalene Brachial Plexus Block With Liposomal Bupivacaine for Arthroscopic Shoulder Surgery

Completed·SSt. Luke's-Roosevelt Hospital Center·Phase 4·NCT01977352·42 enrolled

Urogynecologic Surgery1 trial

Efficacy of Extended-Release Liposomal Bupivacaine for Post-Operative Urogynecologic Surgery

Unknown status·WWalter Reed National Military Medical Center·Phase 4·NCT02287246·120 enrolled

Idiopathic Scoliosis1 trial

IV Methadone Vs EXPAREL Erector Spinae Plane Blockade in Pediatric Subjects Undergoing Idiopathic Scoliosis Correction

Completed·—·Phase 4·NCT05730920·30 enrolled

Anterior Cruciate Ligament Reconstruction1 trial

Exparel Infiltration in Anterior Cruciate Ligament Reconstruction

Completed·HHenry Ford Health System·Phase 4·NCT02606448·84 enrolled

Chronic pain1 trial

Efficacy and Safety of Liposomal Bupivacaine Injection for Paravertebral Nerve Block in the Treatment of Acute and Chronic Pain After Thoracoscopic Pneumonectomy: A Multicenter, Randomized, Double-blind, Controlled Clinical Trial

Recruiting·TThe Second Affiliated Hospital of Chongqing Medical University·Phase 4·NCT06569953·284 enrolled

Aesthetic1 trial

Study of Peri-Articular Anaesthetic for Replacement of the Knee

Completed·UUniversity of Leeds·Phase 3·NCT03326180·533 enrolled

Opioid1 trial

Stopping Opioid Overuse in Obstetrics to Halt Exposure Trial

Active, not recruiting·UUniversity of Missouri, Kansas City·Phase 4·NCT04680221·97 enrolled

Stress urinary incontinence1 trial

Trial Liposomal Bupivacaine Following Retropubic Suburethral Sling for Stress Urinary Incontinence

Completed·TTriHealth Inc.·Phase 4·NCT02296099·114 enrolled

Tonsillectomy1 trial

EXPAREL® for Pain After Tonsillectomy

Completed·MMayo Clinic·Phase 4·NCT02444533·39 enrolled

Clavicle Fracture1 trial

Does Liposomal Bupivacaine Provide Improved Pain Management for ORIF of Midshaft Clavicle Fractures?

Withdrawn·UUniversity of Minnesota·Phase 4·NCT03020563

Lateral Epicondylitis1 trial

Levobupivacaine Versus Liposomal Bupivacaine (Exparel®) for Treatment of Pain and Disability in Lateral Epicondylitis

Unknown status·TTurku University Hospital·Phase 4·NCT04382144·50 enrolled

Intraperitoneal Chemotherapy1 trial

Four Quadrants Transverse Abdominus Plane (4Q-TAP) Block With Plain and Liposomal Bupivacaine vs. Thoracic Epidermal Analgesia (TEA) in Patients Undergoing Cytoreductive Surgery With Hyperthermic Intraperitoneal Chemotherapy (CRS-HIPEC) on an Enhanced Recovery Pathway

Completed·MM.D. Anderson Cancer Center·Phase 3·NCT03359811·75 enrolled

Hernia1 trial

Post-operative Pain Control-TAP Block Using Exparel vs. Marcaine for Hernia Repairs

Active, not recruiting·LLeslie Son·Phase 1·NCT05177991·200 enrolled

Postoperative Pain Management1 trial

TAP Block With Plain Bupivacaine Versus Wound Infiltration With Exparel for Postoperative Pain Management

Completed·UUniversity of Texas Southwestern Medical Center·Phase 4·NCT02074709·60 enrolled

Endometrial Cancer1 trial

Pilot: Intraoperative TAP Block and Post-operative Pain Control for Minimally Invasive Hysterectomy for Endometrial Cancer

Completed·TTufts Medical Center·Phase 3·NCT05763667·15 enrolled

Outcome1 trial

Outcomes for Lumbar Decompressions With Use of Liposomal Bupivicaine

Recruiting·UUniversity of Colorado, Denver·Phase 2·NCT04066296·100 enrolled

Femur Fracture1 trial

Effects of Liposomal Bupivacaine for Acute Pain in Hip and Femur Fractures

Terminated·IIan Elliott Brown·Phase 2·NCT02679560·3 enrolled

Rectus Sheath Block1 trial

Rectus Sheath Block for Analgesia After Gynecological Laparotomy

Completed·—·Phase 4·NCT06575699·90 enrolled

Breast Surgery1 trial

RCT Comparing ESPB Solutions in Breast Surgery

Completed·TTufts Medical Center·Phase 2·NCT04603911·75 enrolled

Total Knee Anthroplasty1 trial

A Randomized Trial of Liposomal Bupivacaine, Ropivacaine With Perineural Dexamethasone, and Ropivacaine With Perineural Dexmedetomidine for Adductor Canal Block Combined With IPACK Block in Total Knee Arthroplasty

Recruiting·HHuazhong University of Science and Technology·Preclinical·NCT07509866·90 enrolled

Coronary Artery Disease1 trial

Effectiveness Of Liposomal Bupivacaine Stellate Ganglion Blockade In Preventing Atrial Fibrillation After Isolated Coronary Artery Bypass Grafting Surgery: A Randomized Placebo-Controlled Trial

Not yet recruiting·MMayo Clinic·Approved·NCT07570940·450 enrolled

Acute Pain1 trial

Liposomal Bupivacaine Combined With Plain Bupivacaine for Peripheral Nerve Block to Reduce Rebound Pain After Orthopedic Extremity Surgery: A Multicenter Randomized Controlled Trial

Not yet recruiting·SShanghai Jiao Tong University Affiliated Sixth People's Hospital·Approved·NCT07606911·668 enrolled

Knee Arthroplasty, Total1 trial

Liposomal Bupivacaine vs Perineural Adjuvants in Adductor Canal and iPACK Blocks in Patients Undergoing Primary Total Knee Arthroplasty

Not yet recruiting·WWake Forest University Health Sciences·Approved·NCT07097493·90 enrolled

Pain, Postoperative1 trial

Liposomal Bupivacaine vs Standard Bupivacaine for Post-Rhinoplasty Analgesia: A Randomized Clinical Trial

Recruiting·WWashington University School of Medicine·Phase 2·NCT07689162·45 enrolled

Fascia1 trial

Fascia Iliaca Block Using Liposomal Bupivacaine for Analgesia After Hip Surgery: a Randomized Trial

Not yet recruiting·PPeking University First Hospital·Approved·NCT07643792·148 enrolled

Diaphragmatic Function1 trial

Evaluation of Diaphragmatic Function After Interscalene Brachial Plexus Block With Liposomal Bupivacaine: A Cohort Study

Recruiting·ZZhejiang University·Preclinical·NCT07263295·120 enrolled

Liver and Intrahepatic Bile Duct Disorder1 trial

Randomized, Unblinded, Phase III Trial of Thoracic Epidural Analgesia Versus Four-Quadrant Transversus Abdominus Plane Block in Oncologic Open-Incision Liver Surgery

Active, not recruiting·MM.D. Anderson Cancer Center·Phase 3·NCT03214510·101 enrolled

Postoperative Acute Pain1 trial

Liposomal Bupivacaine for Acute Pain Management Following Posterior Lumbar Decompression and Fusion Surgery in Adults: A Prospective, Randomized Controlled Trial

Completed·MMin Li·Approved·NCT07171125·204 enrolled

Liposome Bupivacaine1 trial

The Effect of Liposomal Bupivacaine Erector Spinae Plane Block on Postoperative Pain in Patients Undergoing Open Upper Abdominal Surgery: A Randomized, Controlled, Double-Blind Trial

Not yet recruiting·SSecond Affiliated Hospital, School of Medicine, Zhejiang University·Preclinical·NCT07667439·148 enrolled

Unspecified4 trials

Safety, Tolerability, Pharmacokinetic and Pharmacodynamic Profile of HYR-PB21 in Healthy Volunteers

Completed·FFruithy Medical Pty Ltd·Phase 1·NCT04169256·32 enrolled

Exparel vs Exparel Plus ACB in TKAs

Withdrawn·TThe Hawkins Foundation·Phase 4·NCT02365727

Post-operative Exparel Study Following Rotator Cuff Repair

Unknown status·RRothman Institute Orthopaedics·N/A·NCT04047745·132 enrolled

Show 1 more trial

Transverse Abdominus Plane Block Study

Withdrawn·UUniversity of Colorado, Denver·Phase 2·NCT05216055

Sources

References

[1]
ClinicalTrials.gov — 162 trial records for Liposomal bupivacaine. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — Liposomal bupivacaine compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for Liposomal bupivacaine. EMBL-EBI & Wellcome Sanger Institute.
[4]
SEC EDGAR — TLC Biopharmaceuticals, Inc. company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[2]
Highest Phase: Phase 3[1]
Company: TTLC Biopharmaceuticals, Inc.