Ultiva
(Remifentanil)ApprovedSmall molecule
Remifentanil is a strong pain reliever and sedative used during surgery and other medical procedures to keep patients comfortable and help them stay calm while under anesthesia.[2] Ultiva is currently approved and in use across 51 indications[4].[1]
Ultiva is one of 676 small molecule programs targeting Stroke. It is currently in Approved.
51
Indications
333
Total Trials
11
Active Trials
675
Competitors
1
FDA Application
NDA/BLA/ANDA regulatory filings
Pipeline
Status by Indication[4][1]
Indication
Showing 10 of 43 indications
Competition
Competitive Landscape
268 competitors in Colorectal Cancer
#DrugCompanyPhaseTrials
1Camptosar
PfizerPhase 3
Beyfortus
BeiGenePhase 3
Adrucil
EElorac, Inc.
Phase 3
Wellcovorin
EEastern Cooperative Oncology Group
Phase 3
Ultiva
PPfizer's Upjohn has merged with Mylan to form Viatris Inc.
Approved
Bayer Aspirin
BayerPhase 3
Acetylsalicylic Acid
BayerPhase 3
TAS 102
Taiho Oncology, Inc.Phase 3
Systemic Chemotherapy
SSun Yat-sen University
Phase 3
BL-M07D1
SSichuan Baili Pharmaceutical Co., Ltd.
Phase 3
Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.
Timeline
Expected Milestones
Clinical
Trials by Indication[1]
Remifentanil25 trials
Show 22 more trials
Remifentanil and Stress Hormones Response
Completed·—·N/A·NCT03378674·50 enrolled
Remifentanil Requirement for Acceptable Intubating Condition
Completed·—·Phase 4·NCT02655380·51 enrolled
Efficacy of Two Bolus Doses of Remifentanil on the Incidence of Coughing During Emergence of Anesthesia
Completed·—·N/A·NCT01489072·180 enrolled
A Comparison of Esmolol and Remifentanil to Reduce Blood Loss
Unknown status·—·Phase 4·NCT01752959·60 enrolled
Efficacy and Satisfaction With Remifentanil Analgesia in Parturients During the Childbirth
Completed·—··NCT02447757·66 enrolled
Safety of Remifentanil Infusion
Completed·—·Phase 4·NCT01303627·42 enrolled
Efficacy of Remifentanil Compared to Lidocaine on the Incidence of Coughing During Emergence of Anesthesia
Completed·—·N/A·NCT01026129·93 enrolled
EC95 of Remifentanil for Preventing Cough
Completed·—·N/A·NCT02973724·40 enrolled
Remifentanil and Fentanyl in Dental Surgery (REFEDS)
Completed·—·N/A·NCT02619032·46 enrolled
Sedation23 trials
Show 20 more trials
Propofol vs Remifentanil for Sedation in Gastroscopy
Active, not recruiting·FFatih Sultan Mehmet Training and Research Hospital·N/A·NCT07336628·80 enrolled
Dexmedetomidine Sedation in Orthopedic Surgery
Unknown status·—·Phase 2·NCT04149626·60 enrolled
Totally Transdermal Sedation in the Weaning From Remifentanil Infusion
Completed·FFondazione Policlinico Universitario Agostino Gemelli IRCCS·Phase 2·NCT04204967·24 enrolled
the Research of Analgesia and Sedation Effect of Remifentanil on ICU Short Operation
Unknown status·TThe First Affiliated Hospital of Zhengzhou University·Phase 4·NCT02635802·1,500 enrolled
Combination of Remifentanil and Flurbiprofen in Sedation and Analgesia for ESWL of Pancreatic Stone
Completed·—·Phase 4·NCT01998217·60 enrolled
Sedation Strategies for Therapeutic Bronchoscopy 2
Unknown status·—·N/A·NCT03983915·80 enrolled
Sedation Strategies for Therapeutic Bronchoscopy
Terminated·—·N/A·NCT03406546·20 enrolled
Dexmedetomidine7 trials
Dexmedetomidine and Remifentanil in NORA
Completed·—·Phase 4·NCT06403670·76 enrolled
Show 4 more trials
Effect of Dexmedetomidine After Thyroidectomy
Completed·—·N/A·NCT02412150·139 enrolled
The Effect of Dexmedetomidine for Emergence Cough
Completed·—·N/A·NCT03622502·48 enrolled
General Anesthesia7 trials
Comparison of the Effects of Remifentanil and Dexmedetomidine Administered Under General Anesthesia in Rhinoplasty
Completed·—·Phase 4·NCT05572723·50 enrolled
Conditions of Diagnostic Panendoscopy of the Upper Airway Under Propofol Remifentanil General Anesthesia
Completed·—·Phase 3·NCT02093143·256 enrolled
Show 4 more trials
Near Infrared Spectroscopy Cortical Response to Noxious and Auditory Stimuli in Subjects Under General Anesthesia
Completed·—·N/A·NCT02703090·44 enrolled
Opioid Free Anesthesia4 trials
Opioid-free Anesthesia in Thyroidectomies
Unknown status·—·N/A·NCT05243940·60 enrolled
97 more indications
Agitation4 trials
Effect of Deksmedetomidine and Remifentanil in Extubation Agitation
Unknown status·—·Phase 4·NCT02104297·90 enrolled
Scalp Nerve Block on Emergence Agitation
Completed·—·Phase 4·NCT02428283·44 enrolled
Show 1 more trial
Efficacy of Remifentanil in Preventing Emergence Agitation
Recruiting·SSaglik Bilimleri Universitesi Gazi Yasargil Training and Research Hospital·N/A·NCT06539013·99 enrolled
Intraoperative4 trials
Hemodynamic Response4 trials
Effect-site Concentration of Remifentanil for Blunting Hemodynamic Responses to Double-lumen Endobronchial Intubation
Unknown status·—·N/A·NCT02001285·50 enrolled
Anesthesia3 trials
Minimal Flow Anesthesia and Infection Risk
Active, not recruiting·—·N/A·NCT07092046·140 enrolled
Respiratory Depression3 trials
Predictors of Opioid-Induced Respiratory Depression (OIRD)
Completed·—·Phase 1·NCT02473354·30 enrolled
Concentration3 trials
Effect-site Concentration of Remifentanil for Smooth Induction With Desflurane
Completed·—·Phase 4·NCT02379715·26 enrolled
Post Operative Pain3 trials
Effect of Higher Doses of Remifentanil on Postoperative Pain in Patients Undergoing Thyroidectomy
Unknown status·—·Phase 4·NCT01761149·60 enrolled
Cardiac Surgery3 trials
Laryngeal Mask Airway3 trials
Remifentanil for the I-gel and Laryngeal Mask Airway Insertion
Completed·—·Phase 4·NCT02382354·41 enrolled
Laparoscopic Cholecystectomy2 trials
Anesthesia With Propofol, Dexmedetomidine and Lidocaine Infusions for Laparoscopic Cholecystectomy
Completed·—·Phase 4·NCT01833819·80 enrolled
LAPOFAR Trial: Opioid-Free vs. Remifentanil Anesthesia in Laparoscopic Cholecystectomy
Completed·—·N/A·NCT07307625·101 enrolled
Loss of consciousness2 trials
Laparoscopic Sleeve Gastrectomy2 trials
Obstructive Sleep Apnea2 trials
Cataract2 trials
Mechanically Ventilated Patients2 trials
Hyperalgesia2 trials
Post Operative Cognitive Dysfunction2 trials
Epidural Analgesia2 trials
Intensive Care Unit2 trials
Patient-Controlled Analgesia2 trials
General Anaesthesia2 trials
Bronchoscopy2 trials
Complication2 trials
Opioid Analgesia2 trials
Quality of Recovery1 trial
Breast1 trial
MAC vs TIVA Ambulatory Breast Augmentation
Completed·—·Phase 3·NCT03764267·80 enrolled
Delirium1 trial
Neuromuscular Blocking Agents1 trial
Abdominal Surgery1 trial
Infiltration1 trial
Psoas Compartment Block (PCB) Versus L.A Infiltration and Remifentanil Infusion During EVAR
Completed·—·Phase 2·NCT03443518·30 enrolled
Brain Injury1 trial
Treatment of Spontaneous Hyperventilation With Remifentanil in Traumatic Brain Injury Patients
Unknown status·—·N/A·NCT04974060·30 enrolled
Diastolic Dysfunction1 trial
Laryngoscopy1 trial
Subarachnoid Hemorrhage1 trial
Drug Intervention of Spontaneous Hyperventilation in Patients With Aneurysmal Subarachnoid Hemorrhage
Unknown status·—·N/A·NCT04940273·30 enrolled
Spinal Cord Injury1 trial
Electroencephalographic Characteristics of Chronic Pain in Patients With Spinal Cord Injury
Not yet recruiting·—·N/A·NCT06531837·60 enrolled
Mastectomy1 trial
Post Operative Sore Throat1 trial
Gastrointestinal1 trial
The Effect of Anesthetic Methods on Gastrointestinal Motility
Completed·—·N/A·NCT05951686·61 enrolled
Pruritus1 trial
Monitored Anaesthesia Care1 trial
Hernia1 trial
Evaluating Pain Outcomes of Caudal vs Ilioinguinal Nerve Block in Children Undergoing Hernia Repair
Unknown status·—·N/A·NCT03041948·88 enrolled
Tics1 trial
Muscle Relaxation1 trial
Intraocular Pressure1 trial
Effects Of Anaesthesia on Intraocular Pressure in Robotic Prostate Surgery
Completed·—·N/A·NCT07033442·60 enrolled
Total Intravenous Anesthesia1 trial
Randomised Controlled Trial1 trial
Injury1 trial
Prostatectomy1 trial
Respiratory Distress Syndrome1 trial
Surfactant Via Endotracheal Tube vs. Laryngeal Mask Airway (LMA) in Preterm Neonates With Respiratory Distress Syndrome
Terminated·—·Phase 4·NCT02164734·93 enrolled
Head and Neck1 trial
Colorectal Cancer1 trial
Hypotension1 trial
Target Controlled Infusion of Propofol1 trial
THe Comparison of Target Controlled Infusion of Propofol or Etomidate at General Anesthesia in Geriatric Patients
Unknown status·SSecond Affiliated Hospital of Xi'an Jiaotong University·Phase 4·NCT02111265·90 enrolled
Neuromuscular Blockade1 trial
Remifentanil Minimum Effective Dose for Children Intubation Without Neuromuscular Blockade
Completed·—·Phase 4·NCT02454868·30 enrolled
Patient-controlled Intravenous Analgesia1 trial
Local Anesthesia1 trial
Pediatric Patients1 trial
Use of Bispectral Index (BIS) for Monitoring of Total Intravenous Anaesthesia in Pediatric Patients
Terminated·—·N/A·NCT01043952·157 enrolled
Induction Anesthesia1 trial
The Effect of Propofol and Remifentanil Sequence on ED50 and ED95 of Rocuronium in Rapid Sequence Induction Anesthesia
Completed·—·Phase 4·NCT02709473·84 enrolled
Hypotensive Anesthesia1 trial
Nerve Block1 trial
Evaluating Pain Outcomes of Caudal vs Ilioinguinal Nerve Block in Children Undergoing Orchiopexy Repair
Completed·—·N/A·NCT03041935·90 enrolled
PONV1 trial
The Effects of Anesthetic Techniques and Palonosetron Administration on the Incidence of PONV
Completed·—·Phase 4·NCT02809378·150 enrolled
Opioid Consumption1 trial
Oxidative Stress1 trial
Muscle Relaxants1 trial
Nausea and vomiting1 trial
Orthognathic Surgery1 trial
Opioids1 trial
Impact of Opioids on Heart Rate During Rapid Sequence Intubation
Terminated·—·N/A·NCT05384665·3 enrolled
Experimental1 trial
Safety and Efficacy1 trial
Autonomic Nervous System1 trial
Spinal Fusion1 trial
Idiopathic Scoliosis1 trial
Intelligence1 trial
Invasive Mechanical Ventilation1 trial
Pilot Study1 trial
Sunburn1 trial
Myocardial Protection1 trial
Myocardial Protection and Anesthetic Agents
Completed·—·Phase 4·NCT02405689·60 enrolled
Cognitive Function1 trial
Remifentanil/Sufentanil for CABG+/-AVR Evaluated by Recovery, Cognitive Function, Haemodynamics and Biochemical Markers.
Completed·—·Phase 4·NCT02053818·60 enrolled
Post-cardiac Surgery1 trial
Elderly Patients1 trial
Lumbar Spine Surgery1 trial
Opioid Sparing Anesthesia in Lumbar Spine Surgery
Unknown status·—·N/A·NCT05594407·60 enrolled
Unspecified2 trials
Regulatory
FDA Approval Timeline[5]
Jul 12, 1996
ULTIVA
NDA NDA020630
Sources
References
- [1]
- [2]MedlinePlus Drug Information — Ultiva drug information. U.S. National Library of Medicine, National Institutes of Health.
- [3]
- [4]Open Targets Platform — Drug–disease associations for Remifentanil. EMBL-EBI & Wellcome Sanger Institute.
- [5]
- [6]
Details