Ultiva

(Remifentanil)

ApprovedSmall molecule

PPfizer's Upjohn has merged with Mylan to form Viatris Inc.

Remifentanil is a strong pain reliever and sedative used during surgery and other medical procedures to keep patients comfortable and help them stay calm while under anesthesia.[2] Ultiva is currently approved and in use across 55 indications[4].[1]

Ultiva is one of 804 small molecule programs targeting Premature Birth. It is currently in Approved.

Indications

326

Total Trials

Active Trials

803

Competitors

FDA Application

NDA/BLA/ANDA regulatory filings

Pipeline

Status by Indication[4][1]

Indication

Premature BirthApproved

Response to StressActive, not recruiting

Labor and Delivery ComplicationsActive, not recruiting

Breast DiseaseApproved

Neuropathic PainActive, not recruiting

BradycardiaActive, not recruiting

StrokeApproved

Ventricular TachycardiaActive, not recruiting

SunburnActive, not recruiting

Idiopathic ScoliosisActive, not recruiting

Premature BirthApproved

Approved

Response to StressPreclinical

Active, not recruiting

Labor and Delivery ComplicationsPreclinical

Active, not recruiting

Breast DiseaseApproved

Approved

Neuropathic PainPhase 3

Active, not recruiting

BradycardiaPhase 3

Active, not recruiting

StrokeApproved

Approved

Ventricular TachycardiaApproved

Active, not recruiting

SunburnApproved

Active, not recruiting

Idiopathic ScoliosisPhase 2

Active, not recruiting

Showing 10 of 46 indications

Competition

Competitive Landscape

949 competitors in Colorectal Cancer

#DrugCompanyPhaseTrials

Ultiva

PPfizer's Upjohn has merged with Mylan to form Viatris Inc.

Approved

1 2

Emend IV

PORTRAZZA

Bridion

CCidara Therapeutics Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)

Preclinical

1 5

Andriol

AAuxilium

Preclinical

1 6

Feraheme

AAzurity Pharmaceuticals

Preclinical

1 7

Vascepa

AAmarin Pharma Inc.

Preclinical

1 8

Gas-X

PPortuguese Oncology Institute, Coimbra

Preclinical

1 9

Ketalar

AAultman Health Foundation

Preclinical

1 10

Xylocaine

MMEDRx USA, Inc.

Preclinical

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q4 2026

N/ARecruiting

Intraoperative

NCT06091904

Recruiting

Critically Ill Patients

NCT07301970

Q4 2029

N/ARecruiting

Obesity

NCT03756961

Clinical

Trials by Indication[1]

Sedation25 trials

Comparison of Sufentanil, Fentanyl and Remifentanil in Combination With Midazolam During Bronchoscopy Under Conscious Sedation

Completed·GGuangzhou Institute of Respiratory Disease·Phase 4·NCT03901716·60 enrolled

Dexmedetomidine vs. Remifentanil Conscious Sedation for Stapedotomy/Stapedectomy

Completed·IIuliu Hatieganu University of Medicine and Pharmacy·N/A·NCT06283836·74 enrolled

The Effect of Different Sedation Regimes on Cognitive Function in Lower Gastrointestinal System Endoscopy

Completed·UUfuk University·Phase 4·NCT02486328·103 enrolled

Show 22 more trials

Propofol vs Remifentanil for Sedation in Gastroscopy

Active, not recruiting·FFatih Sultan Mehmet Training and Research Hospital·N/A·NCT07336628·80 enrolled

Concepts for Analgosedation During Placement of Regional Anaesthesia Before Operations.

Completed·MMedical University of Graz·Phase 4·NCT04026074·50 enrolled

Step 2 of A Two-step Trial to Evaluate the Effectiveness and Safety of Remimazolam Besylate for Sedation in ICU Patients

Completed·UUnion Hospital, Tongji Medical College, Huazhong University of Science and Technology·Phase 3·NCT05782894·164 enrolled

A Study Comparing Two Analgesia/Sedation Regimens, Remifentanil/Propofol Versus Sufentanil/Propofol In Mechanically Ventilated Intensive Care Patients Requiring Analgesia And Sedation.

Terminated· GSK logo

GSK·Phase 4·NCT00421720·164 enrolled

Combination of Remifentanil and Flurbiprofen in Sedation and Analgesia for ESWL of Pancreatic Stone

Completed·—·Phase 4·NCT01998217·60 enrolled

Dexmedetomidine Sedation in Orthopedic Surgery

Unknown status·—·Phase 2·NCT04149626·60 enrolled

Automated Postoperative Sedation After Cardiac Surgery

Terminated·CCMC Ambroise Paré·N/A·NCT03517735·7 enrolled

Remifentanil Versus Propofol for TCI Sedation of Patients Undergoing Gastrointestinal Endoscopic Procedures

Terminated·FFundación Universitaria de Ciencias de la Salud·Phase 4·NCT01746641·69 enrolled

Sedation Strategies for Therapeutic Bronchoscopy 2

Unknown status·—·N/A·NCT03983915·80 enrolled

A Comparison Between Propofol and Etomidate in Hysteroscopy on Effect of Postoperative Sedation and Cognitive Function in Elderly Patients

Unknown status·SShaanxi Provincial People's Hospital·Phase 4·NCT02147678·120 enrolled

Comparison of Dexmedetomidine and Propofol-Remifentanil Conscious Sedation for Awake Craniotomy for Tumor Surgery

Completed·NNicolai Goettel·N/A·NCT01545297·50 enrolled

Deep Brain Stimulation (DBS) Sedation

Terminated·UUniversity of Wisconsin, Madison·Phase 4·NCT03283150·20 enrolled

Sedation in Endoscopic Retrograde Cholangiopancreatography (ERCP) With or Without Opioids

Completed·UUniversity of Athens·N/A·NCT01304342·180 enrolled

Alfentanil Versus Remifentanil in Patient-controlled Sedation During Endoscopic Retrograde Cholangiopancreatography (ERCP)

Completed·HHelsinki University Central Hospital·Phase 4·NCT01350037·81 enrolled

General Anesthesia Versus Sedation During Intra-arterial Treatment for Stroke

Completed·RRennes University Hospital·Phase 3·NCT02822144·351 enrolled

Electroencephalogram Based Real-Time Sedation Level Prediction

Unknown status·UUniversity Medical Center Groningen··NCT05757622·1,000 enrolled

The Effect Site Concentration of Remifentanil for Conscious Sedation During Awake Nasotracheal Fiberoptic Intubation

Completed·YYonsei University·Phase 4·NCT01052324·19 enrolled

Sedation Strategies for Diagnostic Bronchoscopy

Terminated·—·N/A·NCT03406533·28 enrolled

Comparison of Remifentanil as a Sole Agent or in Combination With Midazolam Versus Fentanyl/Midazolam During Sedation for Colonoscopy

Completed·KKing Hamad University Hospital, Bahrain·N/A·NCT03037892·75 enrolled

Sedation Strategies for Diagnostic Bronchoscopy 2

Unknown status·—·N/A·NCT03983889·200 enrolled

Dexmedetomidine vs. Remifentanil for Sedation During AFI

Completed·TThe University of Texas Health Science Center, Houston·Phase 4·NCT00349245·30 enrolled

The Effect of Analgesia Based Sedation Protocol on Brain Function of Critical Care Patients

Unknown status·PPeking University People's Hospital·Phase 4·NCT02078583·100 enrolled

Remifentanil22 trials

Atropine Effects in Anaesthesia With Sufentanil vs. Remifentanil

Unknown status·UUniversity Medical Center Groningen·N/A·NCT01871935·70 enrolled

Median Effective Dose of Remifentanil for the Prevention of Pain Caused by the Injection of Rocuronium

Unknown status·YYangzhou University·N/A·NCT05217238·70 enrolled

Optimum Dose of Remifentanil for Intubation in Small Children

Completed·UUniversity of British Columbia·Phase 3·NCT00474071·60 enrolled

Show 19 more trials

Efficacy of Two Bolus Doses of Remifentanil on the Incidence of Coughing During Emergence of Anesthesia

Completed·—·N/A·NCT01489072·180 enrolled

Remifentanil and Fentanyl in Dental Surgery (REFEDS)

Completed·—·N/A·NCT02619032·46 enrolled

Remifentanil Only vs. Midazolam and Meperidine During Elective Colonoscopy

Completed·KKonkuk University Medical Center·Phase 4·NCT01693185·60 enrolled

Remifentanil in Extracorporeal Shock Wave Lithotripsy

Completed·UUniversity of Roma La Sapienza·Phase 4·NCT01452880·228 enrolled

Pregabalin and Remifentanil - Analgesia and Ventilation

Completed·OOslo University Hospital·Phase 4·NCT01419405·12 enrolled

VPIA Remifentanil for Labour Pain to Reduce Maternal Desaturation and Improve Analgesic Titration

Unknown status·KKK Women's and Children's Hospital·Phase 4·NCT02733835·25 enrolled

Assessment of the Pharmacodynamic and Pharmacokinetic Interaction of Remimazolam and Remifentanil

Completed·PPaion UK Ltd.·Phase 1·NCT04670471·28 enrolled

Efficacy and Satisfaction With Remifentanil Analgesia in Parturients During the Childbirth

Completed·—··NCT02447757·66 enrolled

A Dose Finding Study of Remifentanil and Propofol for Lumbar Punctures in Children

Completed·TThe Hospital for Sick Children·Phase 1/2·NCT00213239·64 enrolled

A Comparison of the Perioperative Hemodynamic Effects of Remifentanil and Esmolol in Intracranial Surgery

Completed·—·Phase 4·NCT01628562·40 enrolled

Comparison Between Two Different Dosages of Remifentanil During Colonoscopy

Completed·OOspedale San Raffaele·Phase 4·NCT01229527·90 enrolled

Automatic Remifentanil Administration Guided by ANI During Propofol Anesthesia

Completed·UUniversity Hospital, Lille·N/A·NCT03556696·52 enrolled

Comparison of Monitored Anesthesia Care Using Remifentanil or Fentanyl for Major Dressing Changes in Burns

Terminated·MMontreal Burn Centre·Phase 4·NCT00326859·40 enrolled

Efficacy of Remifentanil Compared to Lidocaine on the Incidence of Coughing During Emergence of Anesthesia

Completed·—·N/A·NCT01026129·93 enrolled

EC95 of Remifentanil for Preventing Cough

Completed·—·N/A·NCT02973724·40 enrolled

Median Effective Dose of Remifentanil for the Prevention of Myoclonus Induced by Etomidate Injection

Unknown status·YYangzhou University·N/A·NCT05754762·70 enrolled

Remifentanil and Remimazolam to Limit Patient Movement

Recruiting·EEgymedicalpedia·N/A·NCT06583811·70 enrolled

SPI and Remifentanil in Skull Pin Fixation

Unknown status·KKaohsiung Medical University Chung-Ho Memorial Hospital·Phase 4·NCT06331663·27 enrolled

Optimal Remifentanil Ce for Preventing Severe Cough and Hyperdynamic Response During Tracheal Extubation

Completed·FFundacion Clinica Valle del Lili·Phase 4·NCT03132519·364 enrolled

Hyperalgesia7 trials

The Effect of High-dose Remifentanil on Established Capsaicin-induced Hyperalgesia in Human Volunteers

Unknown status·MMedical University of Vienna·Phase 4·NCT00886106·24 enrolled

The Effect of Remimazolam on Opioid Induced Hyperalgesia

Completed·WWonkwang University Hospital·N/A·NCT05866315·108 enrolled

The Effect of Remifentanil on Established Capsaicin-Induced Hyperalgesia in Human Volunteers

Unknown status·MMedical University of Vienna·Phase 4·NCT00789386·24 enrolled

Show 4 more trials

Effect of Daytime Variation on Postoperative Hyperalgesia Induced by Opioids

Completed·TThe Second Affiliated Hospital of Chongqing Medical University··NCT05234697·60 enrolled

Effect of Ultra-low Dose Naloxone on Remifentanil-Induced Hyperalgesia

Terminated·UUniversity of California, Irvine·Phase 2·NCT03066739·8 enrolled

Remifentanil and Hyperalgesia: Gradual Withdrawal Versus Immediate Discontinuation

Completed·UUniversité Libre de Bruxelles·N/A·NCT03110653·30 enrolled

Modulation of Remifentanil-induced Postinfusion Hyperalgesia

Completed·UUllevaal University Hospital·Phase 4·NCT00785863·16 enrolled

Dexmedetomidine6 trials

Effect of Dexmedetomidine After Thyroidectomy

Completed·—·N/A·NCT02412150·139 enrolled

The Effect of Dexmedetomidine for Emergence Cough

Completed·—·N/A·NCT03622502·48 enrolled

Dexmedetomidine and Remifentanil in NORA

Completed·—·Phase 4·NCT06403670·76 enrolled

Show 3 more trials

Effect of Dexmedetomidine Combined With Low-dose Nalmefene on Preventing Remifentanil-induced Postoperative Hyperalgesia

Completed·TTianjin Medical University General Hospital·N/A·NCT03096730·150 enrolled

The Effects of Dexmedetomidine and Remifentanil on Carotid Patients

Terminated·TThe Cleveland Clinic·Phase 4·NCT00335972·142 enrolled

Remifentanil-dexmedetomidine Anesthesia With a Caudal for Elective Surgery. (Remi-dex)

Withdrawn·MMofya Diallo·Phase 4·NCT02799589

General Anesthesia5 trials

Perioperative Multimodal General AnesTHesia Focusing on Specific CNS Targets in Patients Undergoing carDiac surgERies

Completed·—·N/A·NCT05279898·70 enrolled

Conditions of Diagnostic Panendoscopy of the Upper Airway Under Propofol Remifentanil General Anesthesia

Completed·—·Phase 3·NCT02093143·256 enrolled

Remifentanil for General Anesthesia in the Context of Immaturity

Completed·UUniversity Hospital, Rouen·Phase 1/2·NCT02029898·53 enrolled

Show 2 more trials

Hemodynamics During Induction of General Anesthesia After Prophylactic Ephedrine, Phenylephrine or Norepinephrine.

Completed·HHelse Fonna·Phase 4·NCT03864094·128 enrolled

Neuronal Mechanisms of Sensory Processing During General Anesthesia

Unknown status·LLudwig-Maximilians - University of Munich·N/A·NCT00434382·768 enrolled

94 more indications

Intraoperative5 trials

PRD-guided Analgesia During FESS for Intraoperative Blood Loss

Unknown status·MMedical University of Silesia·N/A·NCT03417206·120 enrolled

Effects of Sufentanil on the Intraoperative Hemodynamics

Recruiting·SSeoul National University Hospital·N/A·NCT06091904·92 enrolled

SPI-guided Analgesia During FESS for Intraoperative Blood Loss

Unknown status·MMedical University of Silesia·N/A·NCT03417180·120 enrolled

Show 2 more trials

SPI-guided vs PRD-guided Analgesia During FESS for Intraoperative Blood Loss

Completed·MMedical University of Silesia·N/A·NCT03389763·105 enrolled

Influence of Intraoperative Analgesia on the Postoperative Morphine Consumption

Completed·HHopital Foch·Phase 4·NCT00772616·60 enrolled

Tics4 trials

Pharmacokinetics and Pharmacodynamics of a New Formulation of Nasal Naloxone for Prehospital Use

Completed·NNorwegian University of Science and Technology·Phase 1/2·NCT02307721·12 enrolled

Synchronous Effect of Anesthetics on fMRI, EEG and Clinical Responses

Completed·PParc de Salut Mar·Phase 1/2·NCT03928366·30 enrolled

Anesthetics and Auditory, Visceral, and Heat Evoked Potentials

Completed·TTechnical University of Munich·Phase 4·NCT00534586·60 enrolled

Show 1 more trial

Comparison of Skin Sympathetic Nerve Activity According to Different Anesthetics

Withdrawn·SSeoul National University Hospital·N/A·NCT03763305

Hemodynamic Response4 trials

Comparision Between Hemodynamic Response of Dexmedetomidine and Remifentanil on Anesthesia in Endoscopic Sinus Surgery

Unknown status·KKorea University Anam Hospital·Phase 4·NCT02464722·50 enrolled

The Effects of Remifentanil on Attenuating the Hemodynamic Responses After Electroconvulsive Therapy

Unknown status·IInonu University·Phase 4·NCT02271555·58 enrolled

The EC50 of Remifentanil Blunting Hemodynamic Response to Double Lumen Tube Intubation

Completed·SSeoul National University Hospital·N/A·NCT01542099·80 enrolled

Show 1 more trial

Effect-site Concentration of Remifentanil for Blunting Hemodynamic Responses to Double-lumen Endobronchial Intubation

Unknown status·—·N/A·NCT02001285·50 enrolled

Concentration4 trials

Optimal Concentration of Remifentanil for NIM Tube Intubation With Low-dose NMBA

Completed·—·N/A·NCT06162390·21 enrolled

Optimal Sevoflurane Concentration for Intubation in Combination of Clincal Remifentanil Doses

Completed·SSeverance Hospital·N/A·NCT02440204·68 enrolled

The Effect Site Concentration of Remifentanil for Preventing QTc Interval Prolongation During Intubation in Normotensive and Hypertensive Patients

Completed·SSeverance Hospital·N/A·NCT01880931·44 enrolled

Show 1 more trial

Effect-site Concentration of Remifentanil for Smooth Induction With Desflurane

Completed·—·Phase 4·NCT02379715·26 enrolled

Anesthesia4 trials

Effect of Remazolam on Anesthesia Recovery in Patients Undergoing Fundus Surgery

Not yet recruiting·SSichuan Provincial People's Hospital·Phase 1·NCT06205719·93 enrolled

Bispectral Index Under Propofol Anesthesia in Children : a Study Between TIVA and TCI

Completed·PPr Isabelle CONSTANT·N/A·NCT02637726·66 enrolled

Automated Anesthesia Guided by the Conox Monitor for Surgery

Terminated·CCMC Ambroise Paré·N/A·NCT03540875·62 enrolled

Show 1 more trial

Narcotic Free TIVA and Incidence of Unacceptable Movements Under Anesthesia During ACDF Surgery

Completed·UUniversity of Arkansas·Phase 4·NCT03643796·32 enrolled

Bronchoscopy3 trials

Remifentanil Plus Ketamine for Dynamic Flexible Bronchoscopy

Withdrawn·—·Phase 4·NCT03613792

Remifentanil Use in Pediatric Rigid Bronchoscopy

Completed·—·Phase 4·NCT01947114·40 enrolled

Clinical Application Value of Remazolam Combined With Sugammadex Sodium in Anesthesia for Endotracheal Surgery Under Bronchoscopy

Completed·ZZhejiang Cancer Hospital·Phase 4·NCT05468671·34 enrolled

Cardiac Surgery3 trials

Requirement of Analgesics After Two Remifentanil Dosing Regimen in Cardiac Surgery.

Completed·KKuopio University Hospital·Phase 4·NCT00757198·90 enrolled

Remifentanil vs Fentanyl During Cardiac Surgery and Chronic Thoracic Pain

Completed·SSt. Antonius Hospital·Phase 4·NCT02031016·126 enrolled

Remifentanil and Glycemic Response in Cardiac Surgery

Completed·UUnknown Sponsor·Phase 4·NCT02349152·116 enrolled

Intensive Care Unit3 trials

A Low Dose Remifentanil Infusion During Tracheal Extubation in Surgical Intensive Care Unit Patients

Completed·SSeverance Hospital·Phase 4·NCT01152515·50 enrolled

Pharmacoeconomic Consequences Of Analgesia in the Intensive Care Unit (ICU)

Terminated· GSK logo

GSK·Phase 3·NCT00436345·39 enrolled

Pharmaco-Economic Study Of Ultiva In Intensive Care Unit(ICU)Subjects

Completed· GSK logo

GSK·Phase 4·NCT00158873·224 enrolled

Agitation3 trials

Emergency Agitation in T&A

Completed·SSeoul National University Bundang Hospital·N/A·NCT01152476·42 enrolled

Effect of Deksmedetomidine and Remifentanil in Extubation Agitation

Unknown status·—·Phase 4·NCT02104297·90 enrolled

Efficacy of Remifentanil in Preventing Emergence Agitation

Recruiting·SSaglik Bilimleri Universitesi Gazi Yasargil Training and Research Hospital·N/A·NCT06539013·99 enrolled

Opioid Free Anesthesia3 trials

Opioid Free Anesthesia in ENT Surgery

Unknown status·UUniversity of Thessaly·N/A·NCT04105946·200 enrolled

Postoperative and Opioid Free Anesthesia

Terminated·RRennes University Hospital·Phase 3·NCT03316339·316 enrolled

OFA - Opioid Free Anesthesia

Unknown status·UUniversity of Parma·Phase 4·NCT03124082·64 enrolled

Opioid-induced Hyperalgesia3 trials

Investigation of the Strategy of Preventing Post-operative Opioid-induced Hyperalgesia

Completed·TTri-Service General Hospital·Phase 4·NCT03812003·41 enrolled

Opioid-induced Hyperalgesia After Remifentanil Infusion

Completed·OOslo University Hospital·Phase 4·NCT01702389·16 enrolled

Pain Response to Cannabidiol in Opioid-induced Hyperalgesia, Acute Nociceptive Pain and Allodynia By Using a Model Mimicking Acute Pain in Healthy Adults

Completed·UUniversity Hospital, Basel, Switzerland·N/A·NCT04059978·21 enrolled

Post Operative Cognitive Dysfunction2 trials

Comparison of Intravenous Anesthetics to Volatile Anesthetics on Postoperative Cognitive Dysfunction

Completed·SSun Yat-sen University·Phase 4·NCT01809041·684 enrolled

Postoperative Cognitive Dysfunction in Transsphenoidal Pituitary Surgeries

Completed·KKocaeli University·Phase 4·NCT06793150·48 enrolled

Epidural Analgesia2 trials

Remifentanil vs. Combined Spinal-epidural Analgesia for Labor Analgesia and Progress of Labor in Multiparous

Completed·UUniversity Medical Centre Ljubljana··NCT02963337·162 enrolled

Effect of Thoracic Epidural Analgesia on Intravenous Closed-Loop Anesthesia

Completed·HHopital Foch·Phase 4·NCT00627081·40 enrolled

Post Operative Pain2 trials

A Comparison of Remifentanil and Dexmedetomidine for Craniotomy Perioperative Hemodynamics and Postoperative Pain

Completed·TThe Cleveland Clinic·N/A·NCT01269918·142 enrolled

Gradual Withdrawal of Remifentanil Infusion Reduced Postoperative Pain and Opioid Requirement During Breast Surgery

Completed·SSamsung Medical Center·N/A·NCT03756233·60 enrolled

Loss of consciousness2 trials

Remifentanil and Midazolam on Propofol for Loss of Consciousness

Completed·SSeverance Hospital·N/A·NCT02536690·120 enrolled

A Phase IV Study Investigating the Effects of Remifentanil Concentrations on Propofol Requirements for Loss of Consciousness, Response to Painful Stimuli, Bispectral Index and Associated Haemodynamic Changes

Completed·TThe University of Hong Kong·Phase 4·NCT02287181·100 enrolled

Hypotension2 trials

Effects of Dexmetomidine and Remifentanil Used for Controlled Hypotension in Septorhinoplasty Surgery on Cardiac Electrophysiology: Prospective Randomized Study

Unknown status·SSaglik Bilimleri Universitesi Gazi Yasargil Training and Research Hospital·N/A·NCT06138574·72 enrolled

Remifentanil and Nitroprusside for Controlled Hypotension

Completed·—·N/A·NCT02001298·30 enrolled

Complication2 trials

Impact of Lidocaine Administration on Postoperative Complications During Lung Resection Surgery

Completed·FFrancisco Andres de la Gala·Phase 4·NCT03905837·156 enrolled

Effect of Remimazolam vs Sevoflurane Anesthesia on Incidence of Emergence Agitation and Complications in Children Undergoing Ophthalmic Surgery

Completed·SSecond Affiliated Hospital of Nanchang University·N/A·NCT05527314·110 enrolled

Patient-Controlled Analgesia2 trials

Intravenous Remifentanil Patient-controlled Analgesia (PCA) and Epidural Patient Controlled Epidural Analgesia (PCEA) for Labor Analgesia

Completed·HHadassah Medical Organization·Phase 4·NCT00801047·50 enrolled

Remifentanil as Intravenous Patient-controlled Analgesia (IVPCA) During Labour

Completed·SSorlandet Hospital HF·Phase 4·NCT00202722·41 enrolled

Postoperative Analgesia2 trials

Controlled-Release Oxycodone For Postoperative Analgesia After Video-Assisted Thoracic Surgery

Terminated·UUniversity of Parma·Phase 4·NCT00681174·22 enrolled

The Epigenetic Modification in OPRM1 on Postoperative Analgesia and Side Effect Induced by Sufentanil

Unknown status·HHuazhong University of Science and Technology·Phase 4·NCT03135795·100 enrolled

Laryngeal Mask Airway2 trials

Optimal Effect-site Concentration of Remifentanil for Inhibiting Response to Laryngeal Mask Airway (LMA) Removal

Completed·SSangjin Park·N/A·NCT01915108·128 enrolled

Dosing Study of Remifentanil for Smooth Removal of the Laryngeal Mask Airway (LMA)

Completed·—·Phase 4·NCT01931683·27 enrolled

Remimazolam2 trials

The Comparison of Remimazolam With Propofol in Core Body Temperature

Completed·WWonkwang University Hospital·Phase 4·NCT05215834·90 enrolled

Remimazolam Phase II Cardiac Anesthesia Study

Completed·PPaion UK Ltd.·Phase 2·NCT01937767·90 enrolled

Mechanically Ventilated Patients2 trials

Efficacy and Safety of Remifentanil for Mechanically Ventilated Patients in ICU

Unknown status·SSoutheast University, China·Phase 3·NCT05003570·138 enrolled

Efficacy and Safety of Remifentanil for Mechanically Ventilated Patients in Intensive Care Unit

Unknown status·SSoutheast University, China·Phase 3·NCT05641909·138 enrolled

Elderly Patients2 trials

Remifentanil for Smooth Emergence in Elderly Patients

Completed·—·Phase 4·NCT02334046·47 enrolled

Remifentanil for Preventing Propofol Injection Pain in Elderly Patients

Completed·—·Phase 4·NCT03330782·52 enrolled

Critically Ill Patients1 trial

Population Pharmacokinetics of Remifentanil in Low-Weight Critically Ill Patients

Recruiting·FFudan University··NCT07301970·45 enrolled

PONV1 trial

The Effects of Anesthetic Techniques and Palonosetron Administration on the Incidence of PONV

Completed·—·Phase 4·NCT02809378·150 enrolled

Efficacy and Safety1 trial

Efficacy and Safety of Oxycodone Hydrochloride for Long-term Analgesia in ICU Patients

Not yet recruiting·SShanghai Zhongshan Hospital·Phase 4·NCT06444997·60 enrolled

Cognitive Functions1 trial

Cognitive Functions After TIVA With Dexmedetomidine

Completed·UUludag University·Phase 4·NCT02631135·40 enrolled

Opioid Consumption1 trial

Pupillometry Guided Remifentanil Administration and Total Opioid Consumption During Propofol - Remifentanil TCI

Completed·PPr Isabelle CONSTANT·N/A·NCT02576600·65 enrolled

Total Intravenous Anesthesia1 trial

Effect of Total Intravenous Anesthesia and Balanced Anesthesia on Postoperative Lung Function

Completed·MMedical University Innsbruck·Phase 4·NCT00706277·60 enrolled

Oxidative Stress1 trial

Effect of Induction and Maintenance of Anesthesia With Etomidate on Hemodynamics and Oxidative Stress in Diabetic Patients

Unknown status·ZZhujiang Hospital·Phase 4·NCT02202239·60 enrolled

Randomised Controlled Trial1 trial

A Randomised Controlled Trial of Remifentanil Intravenous Patient Controlled Analgesia (PCA) Versus Intramuscular Pethidine for Pain Relief in Labour

Completed·UUniversity of Birmingham·Phase 4·NCT02179294·401 enrolled

Muscle Relaxants1 trial

Application of Low-dose Muscle Relaxants in Bronchoscopic Interventional Procedures

Completed·HHarbin Medical University·N/A·NCT07035301·153 enrolled

Nausea and vomiting1 trial

Real-time Decision Support for Postoperative Nausea and Vomiting (PONV) Prophylaxis

Completed·VVanderbilt University·N/A·NCT02625181·27,034 enrolled

Injury1 trial

Myocardial Injury in Remifentanil-based Versus Sevoflurane-sufentanil Balanced Regimens in OPCAB Surgery

Completed·KKonkuk University Medical Center·N/A·NCT02499445·120 enrolled

Analgesic1 trial

The Effect of Analgesic Drugs on Respiratory Center

Unknown status·CChun Pan·Phase 4·NCT04372342·50 enrolled

Aesthetic1 trial

A Study to Compare the Long-term Outcomes After Two Different Anaesthetics

Active, not recruiting·MMurdoch Childrens Research Institute·Phase 3·NCT03089905·450 enrolled

Pediatric Patients1 trial

Use of Closed-loop Anesthesia in Pediatric Patients

Terminated·HHopital Foch·Phase 4·NCT00778505·45 enrolled

Opioids1 trial

Impact of Opioids on Heart Rate During Rapid Sequence Intubation

Terminated·—·N/A·NCT05384665·3 enrolled

Pruritus1 trial

Effect of Remifentanil on Pruritus and Paresthesia of Fospropofol Disodium Anesthesia

Completed·TTongji Hospital·N/A·NCT07092384·265 enrolled

Obstructive Sleep Apnea1 trial

Study of Pain Processing in Subjects Suffering From Obstructive Sleep Apnea

Completed·SStanford University··NCT00672737·56 enrolled

Cognitive Function1 trial

Remifentanil/Sufentanil for CABG+/-AVR Evaluated by Recovery, Cognitive Function, Haemodynamics and Biochemical Markers.

Completed·—·Phase 4·NCT02053818·60 enrolled

Respiratory Depression1 trial

Respiratory Depression During an Analgosedation Combining Remifentanil and Ketamine in TCI for Oocyte Retrieval

Unknown status·EErasme University Hospital··NCT03458143·20 enrolled

Osteoarthritis1 trial

Imaging Pain Relief in Osteoarthritis

Completed·UUniversity of Nottingham·Phase 4·NCT02208778·77 enrolled

Colorectal Cancer1 trial

The Effects of General Anesthetics on Lymphocytes in Patients Undergoing Colorectal Cancer Resection and Mechanism Involved

Unknown status·GGuizhi Du··NCT03193710·260 enrolled

Laparoscopy1 trial

ONSD According to the Position During Laparoscopy

Completed·—·N/A·NCT01937104·60 enrolled

Smooth Emergence1 trial

The Effect of Lidocaine on Smooth Emergence With Double Lumen Tube

Unknown status·—·N/A·NCT04455711·80 enrolled

Analgesia1 trial

Comparison of Different Analgesia-Monitors in Tracing Unconscious Pain Sensations

Completed·UUniversitätsklinikum Hamburg-Eppendorf·N/A·NCT02429960·30 enrolled

Hemodynamic Stability1 trial

Effect of Remifentanil on Hemodynamic Stability During Placement of a Mayfield Head Fixation Device for Craniotomy

Terminated·NNorthwestern University·N/A·NCT02430389·20 enrolled

Post-cardiac Surgery1 trial

Remifentanil Versus Dexmedetomidine for Post-Cardiac Surgery Patients With Noninvasive Ventilation Intolerance

Completed·SShanghai Zhongshan Hospital··NCT03395886·90 enrolled

Aspiration1 trial

Opioid Induced Swallowing Difficulties and Risk for Pulmonary Aspiration

Completed·RRegion Örebro County·Phase 4·NCT01495377·25 enrolled

Laparoscopic Sleeve Gastrectomy1 trial

Anaesthesia for Laparoscopic Sleeve Gastrectomy

Completed·MMenoufia University·N/A·NCT03029715·100 enrolled

Monitored Anaesthesia Care1 trial

Comparison of Remifentanil and Dexmedetomidine for Monitored Anaesthesia Care During Vertebroplasty and Kyphoplasty

Completed·HHallym University Medical Center·N/A·NCT02476981·75 enrolled

Opioid Analgesia1 trial

Evaluation of the Potentiating Effect of tDCS on Opioid Analgesia of Pain Threshold in Humans

Unknown status·HHospital de Clinicas de Porto Alegre·Phase 2·NCT02432677·48 enrolled

Hemodynamic Changes1 trial

The EC90 of Remifentanil Blunting Hemodynamic Changes to Head Fixation

Completed·SSeoul National University Hospital·N/A·NCT01489137·50 enrolled

Target Controlled Infusion of Propofol1 trial

THe Comparison of Target Controlled Infusion of Propofol or Etomidate at General Anesthesia in Geriatric Patients

Unknown status·SSecond Affiliated Hospital of Xi'an Jiaotong University·Phase 4·NCT02111265·90 enrolled

Trial1 trial

The PATHFINDER Study: A Feasibility Trial

Completed·—·Phase 1·NCT04016740·22 enrolled

Induction Anesthesia1 trial

The Effect of Propofol and Remifentanil Sequence on ED50 and ED95 of Rocuronium in Rapid Sequence Induction Anesthesia

Completed·—·Phase 4·NCT02709473·84 enrolled

Treatment1 trial

Esmolol Pretreatment on Pain During Injection of Propofol

Completed·KKyungpook National University Hospital·N/A·NCT01885364·120 enrolled

Nerve Block1 trial

Evaluating Pain Outcomes of Caudal vs Ilioinguinal Nerve Block in Children Undergoing Orchiopexy Repair

Completed·—·N/A·NCT03041935·90 enrolled

Neuropathic Pain1 trial

Influence of Anesthetic Technique on Acute and Chronic Neuropathic Pain

Completed·VVA Pittsburgh Healthcare System·Phase 4·NCT02527083·10 enrolled

Kidney Injury1 trial

The Effects of Dexmedetomidine and Remifentanil on Kidney Injury After Muscle Compression Injury in Rats

Completed·—·N/A·NCT07094165·28 enrolled

Brain Injury1 trial

Remifentanil for Sedation of Patients With Traumatic Brain Injury (TBI)

Completed·JJoseph D. Tobias··NCT02049320·38 enrolled

Tonsillectomy1 trial

Remifentanil Tapering and Post-adenotonsillectomy Pain in Children

Terminated·UUniversity Hospital, Akershus·Phase 4·NCT03994146·6 enrolled

Ventricular Tachycardia1 trial

Remifentanil Intravenous Patient Controlled Analgesia (IVPCA) for Ablation of Idiopathic Ventricular Tachycardia

Completed·NNYU Langone Health·Phase 4·NCT01901575·16 enrolled

Inhalational Anesthesia1 trial

Intravenous Versus Inhalational Anesthesia in Parkinson's Disease

Terminated·—·N/A·NCT00615472·58 enrolled

Surgery1 trial

Assessment of the Nociception During Lumbar Surgery

Completed·UUniversity Hospital, Grenoble·N/A·NCT01015651·16 enrolled

Depth of Anesthesia1 trial

Influence of Depth of Anesthesia on Pupillary Reactivity to a Standardized Stimulus

Completed·HHôpital Armand Trousseau·N/A·NCT02595476·12 enrolled

Spinal Fusion1 trial

Methadone vs Magnesium in Spinal Fusion

Completed·NNationwide Children's Hospital·Phase 2·NCT01795495·63 enrolled

Experimental1 trial

Experimental Medicine Study to Validate Pharmacodynamic Pain Assessments in Healthy Volunteers With an Opioid Analgesic (Remifentanil)

Completed· GSK logo

GSK·Phase 1·NCT02602002·20 enrolled

Prostatectomy1 trial

Analysis of Change of Optic Nerve Sheath Diameter in Robot Assisted Laparoscopic Radical Prostatectomy

Completed·SSeoul National University Hospital·N/A·NCT03152981·60 enrolled

Cataract1 trial

Controlled Sedation for Cataract Surgery

Terminated·FFundación Universitaria de Ciencias de la Salud·Phase 4·NCT03401606·98 enrolled

Pilot Study1 trial

The T REX Pilot Study: a Study to Investigate the Use of an Alternative Anaesthetic in Infants.

Completed·MMurdoch Childrens Research Institute·Phase 4·NCT02353182·60 enrolled

Respiratory Distress Syndrome1 trial

Surfactant Via Endotracheal Tube vs. Laryngeal Mask Airway (LMA) in Preterm Neonates With Respiratory Distress Syndrome

Terminated·—·Phase 4·NCT02164734·93 enrolled

Hernia1 trial

Evaluating Pain Outcomes of Caudal vs Ilioinguinal Nerve Block in Children Undergoing Hernia Repair

Unknown status·—·N/A·NCT03041948·88 enrolled

General Anaesthesia1 trial

Comparison of Sufentanil and Remifentanil Infusion During General Anaesthesia for Removal of Wisdom Teeth in Ambulatory Surgery

Completed·UUniversity Hospital, Clermont-Ferrand·Phase 4·NCT01139671·18 enrolled

Delirium1 trial

The Effect of Remifentanil Infusion During Emergence on the Incidence of Emergence Delirium

Unknown status·YYeungnam University College of Medicine·N/A·NCT02108795·86 enrolled

Neuromuscular Blockade1 trial

Remifentanil Minimum Effective Dose for Children Intubation Without Neuromuscular Blockade

Completed·—·Phase 4·NCT02454868·30 enrolled

Patient-controlled Intravenous Analgesia1 trial

Patient-controlled Intravenous Analgesia With Remifentanil Infusion for Labour

Terminated·SSamuel Lunenfeld Research Institute, Mount Sinai Hospital·N/A·NCT01563939·2 enrolled

Ambulatory Surgery1 trial

Comparison of Desflurane Anesthesia Versus TIVA-TCI in Patients Undergoing Ophthalmic Ambulatory Surgery

Completed·XXiaoliang Gan·N/A·NCT02922660·209 enrolled

Muscle Relaxation1 trial

A Prospective, Multi-center, Randomized Controlled Study of Muscle Relaxation Effect and Safety of Mivacurium Chloride in Pediatric Surgery Patients

Completed·JJiangsu Nhwa Pharmaceutical Co., Ltd.·Phase 4·NCT02117401·1,152 enrolled

Mastectomy1 trial

Inflammatory Effect Comparison Between Fentanyl and Remifentanil in Mastectomy Under General Anesthesia

Completed·UUdayana University·N/A·NCT04435925·48 enrolled

Postoperative Pain Management1 trial

Comparison of the Effectiveness of Intraoperative Intravenous Lidocaine and Intravenous Remifentanil in Postoperative Pain Management in Laparoscopic Cholecystectomy

Completed·—··NCT07312877·138 enrolled

Hysterectomy1 trial

Use of S+Ketamine During Target-Controlled Intravenous Anaesthesia After Abdominal Hysterectomy

Completed·KKK Women's and Children's Hospital·Phase 2·NCT03231683·90 enrolled

Pediatric Anesthesia1 trial

Pupillometry Guided Remifentanil Administration In Pediatric Anesthesia

Withdrawn·UUniversity Hospital, Geneva·N/A·NCT02683837

Ketorolac1 trial

Effect of Spinal Ketorolac After Acute Opioid Exposure

Terminated·WWake Forest University·Phase 2·NCT00693160·30 enrolled

Opioid1 trial

Pharmacodynamics and Arteriovenous Differences of Naloxone in Healthy Participants Exposed to an Opioid

Completed·NNorwegian University of Science and Technology·N/A·NCT02405988·12 enrolled

Sinus Surgery1 trial

Comparison of Metoprolol and Tramadol With Remifentanil in Endoscopic Sinus Surgery

Completed·RRecep Tayyip Erdogan University·Phase 4·NCT02484859·88 enrolled

Esketamine1 trial

Remiazolam Combined With Esketamine in Painless Bidirectional Endoscopy in Children

Completed·TTongji Hospital·N/A·NCT05686863·106 enrolled

Mechanical Ventilation1 trial

Compare the Effects of Remifentanil and Fentanyl on the Duration of Mechanical Ventilation of ICU Patients

Unknown status·—·Phase 4·NCT05014711·254 enrolled

Bradycardia1 trial

Determination of Remifentanil's ED50 for Rapid Sequence Intubation Avoiding Bradycardia and Hypotension in Adults

Completed·—·Phase 3·NCT03065309·15 enrolled

Obesity1 trial

Effects of an Opioid Free/Sparing Care Pathway for Patients Undergoing Obesity Surgery

Recruiting·GGöteborg University·N/A·NCT03756961·220 enrolled

Preoperative1 trial

New Options for Preoperative Anesthesia in Intrauterine Needling

Completed·LLeiden University Medical Center·Phase 1·NCT01013558·50 enrolled

Sunburn1 trial

The Effect of Remifentanil on Established Sunburn-induced Hyperalgesia in Human Volunteers

Unknown status·MMedical University of Vienna·Phase 4·NCT00811837·24 enrolled

Unspecified2 trials

ULTIVA Post Marketing Surveillance

Completed· GSK logo

GSK··NCT01299584·775 enrolled

Anesthetic Techniques in EP Patients

Terminated·UUniversity of California, Los Angeles·Phase 4·NCT02664922·35 enrolled

Regulatory

FDA Approval Timeline[5]

Jul 12, 1996

ULTIVA

NDA NDA020630

Sources

References

[1]
ClinicalTrials.gov — 326 trial records for Remifentanil. U.S. National Library of Medicine, National Institutes of Health.
[2]
MedlinePlus Drug Information — Ultiva drug information. U.S. National Library of Medicine, National Institutes of Health.
[3]
ChEMBL — Remifentanil compound record. European Bioinformatics Institute (EMBL-EBI).
[4]
Open Targets Platform — Drug–disease associations for Remifentanil. EMBL-EBI & Wellcome Sanger Institute.
[5]
OpenFDA — FDA approval records (NDA NDA020630). U.S. Food & Drug Administration.
[6]
SEC EDGAR — Pfizer's Upjohn has merged with Mylan to form Viatris Inc. company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Mechanism of Action: Mu Opioid Receptor Agonist[3]
Modality: Small molecule[3]
Highest Phase: Approved[1]
Company: PPfizer's Upjohn has merged with Mylan to form Viatris Inc.