Ultiva

(Remifentanil)

ApprovedSmall molecule

PPfizer's Upjohn has merged with Mylan to form Viatris Inc.

Remifentanil is a strong pain reliever and sedative used during surgery and other medical procedures to keep patients comfortable and help them stay calm while under anesthesia.[2] Ultiva is currently approved and in use across 50 indications[4].[1]

Ultiva is one of 668 small molecule programs targeting Premature Birth. It is currently in Approved.

Indications

335

Total Trials

Active Trials

667

Competitors

FDA Applications

NDA/BLA/ANDA regulatory filings

Pipeline

Status by Indication[4][1]

Indication

Premature BirthApproved

Response to StressActive, not recruiting

Labor and Delivery ComplicationsActive, not recruiting

Breast DiseaseApproved

StrokeApproved

Ventricular TachycardiaCompleted

SunburnUnknown status

Brain InjuryActive, not recruiting

DeliriumActive, not recruiting

Kidney InjuryActive, not recruiting

Premature BirthApproved

Approved

Response to StressPreclinical

Active, not recruiting

Labor and Delivery ComplicationsPreclinical

Active, not recruiting

Breast DiseaseApproved

Approved

StrokeApproved

Approved

Ventricular TachycardiaApproved

Completed

SunburnApproved

Unknown status

Brain InjuryPreclinical

Active, not recruiting

DeliriumPreclinical

Active, not recruiting

Kidney InjuryPreclinical

Active, not recruiting

Showing 10 of 42 indications

Competition

Competitive Landscape

254 competitors in Colorectal Cancer

#DrugCompanyPhaseTrials

Stivarga

Bayer

Phase 3

39 2

Fudr

Pfizer

Phase 3

17 3

Adrucil

EElorac, Inc.

Phase 3

86 4

Wellcovorin

EEastern Cooperative Oncology Group

Phase 3

58 5

Ultiva

PPfizer's Upjohn has merged with Mylan to form Viatris Inc.

Approved

1 6

Acetylsalicylic Acid

Bayer

Phase 3

6 7

XL092

Roche

Phase 3

1 8

Huaier Granule

QQidong Gaitianli Medicines Co., Ltd

Phase 3

4 9

PD-1 Monoclonal Antibody

SSichuan Baili Pharmaceutical Co., Ltd.

Phase 3

2 10

Cytokine-Induced Killer Cells

TThe First People's Hospital of Changzhou

Phase 3

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q4 2026

Recruiting

Critically Ill Patients

NCT07301970

Q4 2029

N/ARecruiting

Obesity

NCT03756961

Clinical

Trials by Indication[1]

Sedation30 trials

Automated Postoperative Sedation After Cardiac Surgery

Terminated·CCMC Ambroise Paré·N/A·NCT03517735·7 enrolled

The Effect Site Concentration of Remifentanil for Conscious Sedation During Awake Nasotracheal Fiberoptic Intubation

Completed·YYonsei University·Phase 4·NCT01052324·19 enrolled

Comparison of Remifentanil as a Sole Agent or in Combination With Midazolam Versus Fentanyl/Midazolam During Sedation for Colonoscopy

Completed·KKing Hamad University Hospital, Bahrain·N/A·NCT03037892·75 enrolled

Show 27 more trials

Sedation Strategies for Diagnostic Bronchoscopy 2

Unknown status·—·N/A·NCT03983889·200 enrolled

Comparison of Sufentanil, Fentanyl and Remifentanil in Combination With Midazolam During Bronchoscopy Under Conscious Sedation

Completed·GGuangzhou Institute of Respiratory Disease·Phase 4·NCT03901716·60 enrolled

Dexmedetomidine vs. Remifentanil Conscious Sedation for Stapedotomy/Stapedectomy

Completed·IIuliu Hatieganu University of Medicine and Pharmacy·N/A·NCT06283836·74 enrolled

The Effect of Different Sedation Regimes on Cognitive Function in Lower Gastrointestinal System Endoscopy

Completed·UUfuk University·Phase 4·NCT02486328·103 enrolled

Propofol vs Remifentanil for Sedation in Gastroscopy

Active, not recruiting·FFatih Sultan Mehmet Training and Research Hospital·N/A·NCT07336628·80 enrolled

Alfentanil Versus Remifentanil in Patient-controlled Sedation During Endoscopic Retrograde Cholangiopancreatography (ERCP)

Completed·HHelsinki University Central Hospital·Phase 4·NCT01350037·81 enrolled

General Anesthesia Versus Sedation During Intra-arterial Treatment for Stroke

Completed·RRennes University Hospital·Phase 3·NCT02822144·351 enrolled

Changes of the Neuronal Activity in the Subthalamic Nucleus Under Remifentanil Sedation During Stereotactic Electrode Implantation

Unknown status·HHadassah Medical Organization·N/A·NCT00588926·20 enrolled

Step 2 of A Two-step Trial to Evaluate the Effectiveness and Safety of Remimazolam Besylate for Sedation in ICU Patients

Completed·UUnion Hospital, Tongji Medical College, Huazhong University of Science and Technology·Phase 3·NCT05782894·164 enrolled

Dexmedetomidine Sedation in Orthopedic Surgery

Unknown status·—·Phase 2·NCT04149626·60 enrolled

Electroencephalogram Based Real-Time Sedation Level Prediction

Unknown status·UUniversity Medical Center Groningen··NCT05757622·1,000 enrolled

Dexmedetomidine vs. Remifentanil for Sedation During AFI

Completed·TThe University of Texas Health Science Center, Houston·Phase 4·NCT00349245·30 enrolled

Remifentanil Versus Morphine for Sedation of Premature Neonates With Respiratory Distress Syndrome

Completed·FFederal University of Minas Gerais·Phase 4·NCT00391105

Sedation Strategies for Therapeutic Bronchoscopy

Terminated·—·N/A·NCT03406546·20 enrolled

the Research of Analgesia and Sedation Effect of Remifentanil on ICU Short Operation

Unknown status·TThe First Affiliated Hospital of Zhengzhou University·Phase 4·NCT02635802·1,500 enrolled

Conscious Sedation for Outpatient Colonoscopy

Completed·MMenoufia University·Phase 2·NCT03925779·80 enrolled

Sedation Versus General Anesthesia for Endovascular Therapy in Acute Stroke - Impact on Neurological Outcome

Completed·SSahlgrenska University Hospital·N/A·NCT01872884·90 enrolled

Totally Transdermal Sedation in the Weaning From Remifentanil Infusion

Completed·FFondazione Policlinico Universitario Agostino Gemelli IRCCS·Phase 2·NCT04204967·24 enrolled

Sedation With Dexmedetomidine Versus Remifentanil in Urogynecological Surgery Under Spinal Anaesthesia

Unknown status·UUniversity of Athens·Phase 3·NCT03883347·50 enrolled

Effects of Two Different Sedation Regimes on Auditory Evoked Potentials and Electroencephalogram (EEG)

Completed·IInsel Gruppe AG, University Hospital Bern·N/A·NCT00641563·10 enrolled

Remifentanil Versus Propofol for TCI Sedation of Patients Undergoing Gastrointestinal Endoscopic Procedures

Terminated·FFundación Universitaria de Ciencias de la Salud·Phase 4·NCT01746641·69 enrolled

A Comparison Between Propofol and Etomidate in Hysteroscopy on Effect of Postoperative Sedation and Cognitive Function in Elderly Patients

Unknown status·SShaanxi Provincial People's Hospital·Phase 4·NCT02147678·120 enrolled

Comparison of Dexmedetomidine and Propofol-Remifentanil Conscious Sedation for Awake Craniotomy for Tumor Surgery

Completed·NNicolai Goettel·N/A·NCT01545297·50 enrolled

Deep Brain Stimulation (DBS) Sedation

Terminated·UUniversity of Wisconsin, Madison·Phase 4·NCT03283150·20 enrolled

Sedation in Endoscopic Retrograde Cholangiopancreatography (ERCP) With or Without Opioids

Completed·UUniversity of Athens·N/A·NCT01304342·180 enrolled

A Study Comparing Two Analgesia/Sedation Regimens, Remifentanil/Propofol Versus Sufentanil/Propofol In Mechanically Ventilated Intensive Care Patients Requiring Analgesia And Sedation.

Terminated· GSK logo

GSK·Phase 4·NCT00421720·164 enrolled

Combination of Remifentanil and Flurbiprofen in Sedation and Analgesia for ESWL of Pancreatic Stone

Completed·—·Phase 4·NCT01998217·60 enrolled

Remifentanil21 trials

Median Effective Dose of Remifentanil for the Prevention of Myoclonus Induced by Etomidate Injection

Unknown status·YYangzhou University·N/A·NCT05754762·70 enrolled

Atropine Effects in Anaesthesia With Sufentanil vs. Remifentanil

Unknown status·UUniversity Medical Center Groningen·N/A·NCT01871935·70 enrolled

Median Effective Dose of Remifentanil for the Prevention of Pain Caused by the Injection of Rocuronium

Unknown status·YYangzhou University·N/A·NCT05217238·70 enrolled

Show 18 more trials

Efficacy of Two Bolus Doses of Remifentanil on the Incidence of Coughing During Emergence of Anesthesia

Completed·—·N/A·NCT01489072·180 enrolled

Effect of Remifentanil Boluses on Hemodynamics in Skull Pin Insertion

Completed·UUniversity Health Network, Toronto·N/A·NCT01056224·72 enrolled

Remifentanil and Fentanyl in Dental Surgery (REFEDS)

Completed·—·N/A·NCT02619032·46 enrolled

Remifentanil in Extracorporeal Shock Wave Lithotripsy

Completed·UUniversity of Roma La Sapienza·Phase 4·NCT01452880·228 enrolled

Remifentanil and Remimazolam to Limit Patient Movement

Recruiting·EEgymedicalpedia·N/A·NCT06583811·70 enrolled

SPI and Remifentanil in Skull Pin Fixation

Unknown status·KKaohsiung Medical University Chung-Ho Memorial Hospital·Phase 4·NCT06331663·27 enrolled

A Comparison of the Effects of Ketamine and Remifentanil on Serum Cystatin-c Levels in CABG Surgery

Completed·TTurkiye Yuksek Ihtisas Education and Research Hospital·Phase 4·NCT02113150·37 enrolled

Drip-infusion of Remifentanil for RIH

Completed·TTri-Service General Hospital··NCT04387097·559 enrolled

The Effects of Remifentanil and Remifentanil-Alfentanil Administration in Children

Completed·HHallym University Medical Center·N/A·NCT02486926·102 enrolled

Efficacy of Alkalinized Lidocaine Compared to Remifentanil on the Incidence of Coughing During Emergence of Anesthesia

Completed·—·N/A·NCT01451840·85 enrolled

Optimal Remifentanil Ce for Preventing Severe Cough and Hyperdynamic Response During Tracheal Extubation

Completed·FFundacion Clinica Valle del Lili·Phase 4·NCT03132519·364 enrolled

Effect of Remifentanil on Electroencephalographic BAR Index During Propofol Anaesthesia

Completed·MMelbourne Health·Phase 1·NCT00455026·45 enrolled

Remifentanil Infusion Alone During the Closure Period for Early Emergence Following Craniotomy

Completed·YYeditepe University Hospital·Phase 4·NCT02593942·80 enrolled

A Comparison of Esmolol and Remifentanil to Reduce Blood Loss

Unknown status·—·Phase 4·NCT01752959·60 enrolled

ANI and Remifentanil in Skull Pin Fixation.

Completed·KKaohsiung Medical University Chung-Ho Memorial Hospital·Phase 4·NCT05125328·27 enrolled

Efficacy and Satisfaction With Remifentanil Analgesia in Parturients During the Childbirth

Completed·—··NCT02447757·66 enrolled

A Dose Finding Study of Remifentanil and Propofol for Lumbar Punctures in Children

Completed·TThe Hospital for Sick Children·Phase 1/2·NCT00213239·64 enrolled

Comparison Between Two Different Dosages of Remifentanil During Colonoscopy

Completed·OOspedale San Raffaele·Phase 4·NCT01229527·90 enrolled

General Anesthesia6 trials

Remifentanil for General Anesthesia in Preeclamptics

Unknown status·IIstanbul University·Phase 4·NCT00567957·50 enrolled

Effect of Remifentanil on Cough During Emergence From General Anesthesia : Trial to Compare Between Sevoflurane Anesthesia and Propofol Anesthesia

Completed·YYonsei University·Phase 4·NCT01240109·70 enrolled

Near Infrared Spectroscopy Cortical Response to Noxious and Auditory Stimuli in Subjects Under General Anesthesia

Completed·—·N/A·NCT02703090·44 enrolled

Show 3 more trials

Hemodynamics During Induction of General Anesthesia After Prophylactic Ephedrine, Phenylephrine or Norepinephrine.

Completed·HHelse Fonna·Phase 4·NCT03864094·128 enrolled

Neuronal Mechanisms of Sensory Processing During General Anesthesia

Unknown status·LLudwig-Maximilians - University of Munich·N/A·NCT00434382·768 enrolled

Remifentanil for General Anesthesia in the Context of Immaturity

Completed·UUniversity Hospital, Rouen·Phase 1/2·NCT02029898·53 enrolled

Anesthesia5 trials

Effect of Remazolam on Anesthesia Recovery in Patients Undergoing Fundus Surgery

Not yet recruiting·SSichuan Provincial People's Hospital·Phase 1·NCT06205719·93 enrolled

Bispectral Index Under Propofol Anesthesia in Children : a Study Between TIVA and TCI

Completed·PPr Isabelle CONSTANT·N/A·NCT02637726·66 enrolled

Automated Anesthesia Guided by the Conox Monitor for Surgery

Terminated·CCMC Ambroise Paré·N/A·NCT03540875·62 enrolled

Show 2 more trials

Narcotic Free TIVA and Incidence of Unacceptable Movements Under Anesthesia During ACDF Surgery

Completed·UUniversity of Arkansas·Phase 4·NCT03643796·32 enrolled

Sufentanil as Adjuvant of Balanced Anesthesia

Completed·KKangbuk Samsung Hospital·N/A·NCT03868111·66 enrolled

Hyperalgesia5 trials

Remifentanil and Hyperalgesia: Gradual Withdrawal Versus Immediate Discontinuation

Completed·UUniversité Libre de Bruxelles·N/A·NCT03110653·30 enrolled

Effect of Ultra-low Dose Naloxone on Remifentanil-Induced Hyperalgesia

Terminated·UUniversity of California, Irvine·Phase 2·NCT03066739·8 enrolled

Modulation of Remifentanil-induced Postinfusion Hyperalgesia

Completed·UUllevaal University Hospital·Phase 4·NCT00785863·16 enrolled

Show 2 more trials

Effect of Butorphanol Combined With Flurbiprofen Axetil on Preventing Hyperalgesia Induced by Remifentanil in Patients

Completed·TTianjin Medical University General Hospital·N/A·NCT02043366·180 enrolled

Effect of Daytime Variation on Postoperative Hyperalgesia Induced by Opioids

Completed·TThe Second Affiliated Hospital of Chongqing Medical University··NCT05234697·60 enrolled

91 more indications

Hemodynamic Response5 trials

Comparision Between Hemodynamic Response of Dexmedetomidine and Remifentanil on Anesthesia in Endoscopic Sinus Surgery

Unknown status·KKorea University Anam Hospital·Phase 4·NCT02464722·50 enrolled

The Effects of Remifentanil on Attenuating the Hemodynamic Responses After Electroconvulsive Therapy

Unknown status·IInonu University·Phase 4·NCT02271555·58 enrolled

The EC50 of Remifentanil Blunting Hemodynamic Response to Double Lumen Tube Intubation

Completed·SSeoul National University Hospital·N/A·NCT01542099·80 enrolled

Show 2 more trials

Effect-site Concentration of Remifentanil for Blunting Hemodynamic Responses to Double-lumen Endobronchial Intubation

Unknown status·—·N/A·NCT02001285·50 enrolled

Comparison of Dexmedetomidin and Remifentanil for the Effect on Airway Reflex and Hemodynamic Response During Emergence in Patients Undergoing Craniotomy

Completed·YYonsei University·Phase 4·NCT01365923·74 enrolled

Dexmedetomidine5 trials

Dexmedetomidine and Remifentanil in NORA

Completed·—·Phase 4·NCT06403670·76 enrolled

Effect of Dexmedetomidine Combined With Low-dose Nalmefene on Preventing Remifentanil-induced Postoperative Hyperalgesia

Completed·TTianjin Medical University General Hospital·N/A·NCT03096730·150 enrolled

The Effects of Dexmedetomidine and Remifentanil on Carotid Patients

Terminated·TThe Cleveland Clinic·Phase 4·NCT00335972·142 enrolled

Show 2 more trials

Effect of Dexmedetomidine on Nol-Index Guided Remifentanil Analgesia

Completed·EErasme University Hospital·N/A·NCT03912740·58 enrolled

Safety Evaluation of Dexmedetomidine for EBUS-TBNA

Unknown status·MMaisonneuve-Rosemont Hospital·Phase 4·NCT01381627·60 enrolled

Tics4 trials

Comparison of Skin Sympathetic Nerve Activity According to Different Anesthetics

Withdrawn·SSeoul National University Hospital·N/A·NCT03763305

Pharmacokinetics and Pharmacodynamics of a New Formulation of Nasal Naloxone for Prehospital Use

Completed·NNorwegian University of Science and Technology·Phase 1/2·NCT02307721·12 enrolled

Synchronous Effect of Anesthetics on fMRI, EEG and Clinical Responses

Completed·PParc de Salut Mar·Phase 1/2·NCT03928366·30 enrolled

Show 1 more trial

Anesthetics and Auditory, Visceral, and Heat Evoked Potentials

Completed·TTechnical University of Munich·Phase 4·NCT00534586·60 enrolled

Concentration3 trials

The Effect Site Concentration of Remifentanil for Preventing QTc Interval Prolongation During Intubation in Normotensive and Hypertensive Patients

Completed·SSeverance Hospital·N/A·NCT01880931·44 enrolled

Effect-site Concentration of Remifentanil for Smooth Induction With Desflurane

Completed·—·Phase 4·NCT02379715·26 enrolled

Optimal Sevoflurane Concentration for Intubation in Combination of Clincal Remifentanil Doses

Completed·SSeverance Hospital·N/A·NCT02440204·68 enrolled

Opioid-induced Hyperalgesia3 trials

Opioid-induced Hyperalgesia After Remifentanil Infusion

Completed·OOslo University Hospital·Phase 4·NCT01702389·16 enrolled

Pain Response to Cannabidiol in Opioid-induced Hyperalgesia, Acute Nociceptive Pain and Allodynia By Using a Model Mimicking Acute Pain in Healthy Adults

Completed·UUniversity Hospital, Basel, Switzerland·N/A·NCT04059978·21 enrolled

Investigation of the Strategy of Preventing Post-operative Opioid-induced Hyperalgesia

Completed·TTri-Service General Hospital·Phase 4·NCT03812003·41 enrolled

Bronchoscopy3 trials

Remifentanil Use in Pediatric Rigid Bronchoscopy

Completed·—·Phase 4·NCT01947114·40 enrolled

Clinical Application Value of Remazolam Combined With Sugammadex Sodium in Anesthesia for Endotracheal Surgery Under Bronchoscopy

Completed·ZZhejiang Cancer Hospital·Phase 4·NCT05468671·34 enrolled

Remifentanil Plus Ketamine for Dynamic Flexible Bronchoscopy

Withdrawn·—·Phase 4·NCT03613792

Cardiac Surgery3 trials

Requirement of Analgesics After Two Remifentanil Dosing Regimen in Cardiac Surgery.

Completed·KKuopio University Hospital·Phase 4·NCT00757198·90 enrolled

Remifentanil vs Fentanyl During Cardiac Surgery and Chronic Thoracic Pain

Completed·SSt. Antonius Hospital·Phase 4·NCT02031016·126 enrolled

Remifentanil and Glycemic Response in Cardiac Surgery

Completed·UUnknown Sponsor·Phase 4·NCT02349152·116 enrolled

Agitation3 trials

Scalp Nerve Block on Emergence Agitation

Completed·—·Phase 4·NCT02428283·44 enrolled

Emergency Agitation in T&A

Completed·SSeoul National University Bundang Hospital·N/A·NCT01152476·42 enrolled

Efficacy of Remifentanil in Preventing Emergence Agitation

Recruiting·SSaglik Bilimleri Universitesi Gazi Yasargil Training and Research Hospital·N/A·NCT06539013·99 enrolled

Intraoperative3 trials

Effect of Intraoperative Remifentanil Infusion Rate on Postoperative Tolerance and Analgesic Consumption in Pediatric Laparoscopic Ureteroneocystostomy

Unknown status·YYonsei University·N/A·NCT01147757·60 enrolled

Effects of Sufentanil on the Intraoperative Hemodynamics

Recruiting·SSeoul National University Hospital·N/A·NCT06091904·92 enrolled

Influence of Intraoperative Analgesia on the Postoperative Morphine Consumption

Completed·HHopital Foch·Phase 4·NCT00772616·60 enrolled

Elderly Patients3 trials

Remifentanil for Smooth Emergence in Elderly Patients

Completed·—·Phase 4·NCT02334046·47 enrolled

Remifentanil for Preventing Propofol Injection Pain in Elderly Patients

Completed·—·Phase 4·NCT03330782·52 enrolled

The Effect Site Concentration of Remifentanil for Preventing QTc Interval Prolongation During Intubation Under Propofol-remifentanil Anesthesia in Elderly Patients

Completed·SSeverance Hospital·N/A·NCT01720498·50 enrolled

Opioid Free Anesthesia3 trials

Opioid Free Anesthesia in ENT Surgery

Unknown status·UUniversity of Thessaly·N/A·NCT04105946·200 enrolled

Postoperative and Opioid Free Anesthesia

Terminated·RRennes University Hospital·Phase 3·NCT03316339·316 enrolled

OFA - Opioid Free Anesthesia

Unknown status·UUniversity of Parma·Phase 4·NCT03124082·64 enrolled

Mechanically Ventilated Patients2 trials

Efficacy and Safety of Remifentanil for Mechanically Ventilated Patients in Intensive Care Unit

Unknown status·SSoutheast University, China·Phase 3·NCT05641909·138 enrolled

Efficacy and Safety of Remifentanil for Mechanically Ventilated Patients in ICU

Unknown status·SSoutheast University, China·Phase 3·NCT05003570·138 enrolled

Post Operative Pain2 trials

Gradual Withdrawal of Remifentanil Infusion Reduced Postoperative Pain and Opioid Requirement During Breast Surgery

Completed·SSamsung Medical Center·N/A·NCT03756233·60 enrolled

A Comparison of Remifentanil and Dexmedetomidine for Craniotomy Perioperative Hemodynamics and Postoperative Pain

Completed·TThe Cleveland Clinic·N/A·NCT01269918·142 enrolled

Epidural Analgesia2 trials

Remifentanil vs. Combined Spinal-epidural Analgesia for Labor Analgesia and Progress of Labor in Multiparous

Completed·UUniversity Medical Centre Ljubljana··NCT02963337·162 enrolled

Effect of Thoracic Epidural Analgesia on Intravenous Closed-Loop Anesthesia

Completed·HHopital Foch·Phase 4·NCT00627081·40 enrolled

Loss of consciousness2 trials

Remifentanil and Midazolam on Propofol for Loss of Consciousness

Completed·SSeverance Hospital·N/A·NCT02536690·120 enrolled

A Phase IV Study Investigating the Effects of Remifentanil Concentrations on Propofol Requirements for Loss of Consciousness, Response to Painful Stimuli, Bispectral Index and Associated Haemodynamic Changes

Completed·TThe University of Hong Kong·Phase 4·NCT02287181·100 enrolled

Pediatric Patients2 trials

Use of Closed-loop Anesthesia in Pediatric Patients

Terminated·HHopital Foch·Phase 4·NCT00778505·45 enrolled

Use of Bispectral Index (BIS) for Monitoring of Total Intravenous Anaesthesia in Pediatric Patients

Terminated·—·N/A·NCT01043952·157 enrolled

Opioid Analgesia2 trials

Non-opioid Analgesia for Fast-track Surgery

Completed·MMcGill University Health Centre/Research Institute of the McGill University Health Centre·N/A·NCT01275911·40 enrolled

Evaluation of the Potentiating Effect of tDCS on Opioid Analgesia of Pain Threshold in Humans

Unknown status·HHospital de Clinicas de Porto Alegre·Phase 2·NCT02432677·48 enrolled

Respiratory Depression2 trials

Predictors of Opioid-Induced Respiratory Depression (OIRD)

Completed·—·Phase 1·NCT02473354·30 enrolled

Respiratory Depression During an Analgosedation Combining Remifentanil and Ketamine in TCI for Oocyte Retrieval

Unknown status·EErasme University Hospital··NCT03458143·20 enrolled

Laryngeal Mask Airway2 trials

Remifentanil for the I-gel and Laryngeal Mask Airway Insertion

Completed·—·Phase 4·NCT02382354·41 enrolled

Optimal Effect-site Concentration of Remifentanil for Inhibiting Response to Laryngeal Mask Airway (LMA) Removal

Completed·SSangjin Park·N/A·NCT01915108·128 enrolled

Hypotension2 trials

Effects of Dexmetomidine and Remifentanil Used for Controlled Hypotension in Septorhinoplasty Surgery on Cardiac Electrophysiology: Prospective Randomized Study

Unknown status·SSaglik Bilimleri Universitesi Gazi Yasargil Training and Research Hospital·N/A·NCT06138574·72 enrolled

Remifentanil and Nitroprusside for Controlled Hypotension

Completed·—·N/A·NCT02001298·30 enrolled

General Anaesthesia2 trials

Effect of Remifentanil on the Bispectral Index in Women Undergoing Caesarean Delivery Under General Anaesthesia

Completed·WWest China Second University Hospital·N/A·NCT03508102·60 enrolled

Comparison of Sufentanil and Remifentanil Infusion During General Anaesthesia for Removal of Wisdom Teeth in Ambulatory Surgery

Completed·UUniversity Hospital, Clermont-Ferrand·Phase 4·NCT01139671·18 enrolled

Mastectomy2 trials

Inflammatory Effect Comparison Between Fentanyl and Remifentanil in Mastectomy Under General Anesthesia

Completed·UUdayana University·N/A·NCT04435925·48 enrolled

Effect of Intravenous Infusion of Lidocaine and Remifentanil Perioperatively in Patients Undergoing Mastectomy

Completed·HHospital de Base·Phase 4·NCT02291094·60 enrolled

Opioid2 trials

Pharmacodynamics and Arteriovenous Differences of Naloxone in Healthy Participants Exposed to an Opioid

Completed·NNorwegian University of Science and Technology·N/A·NCT02405988·12 enrolled

Opioid Effects on Swallowing and Esophageal Sphincter Pressure

Completed·RRegion Örebro County·Phase 4·NCT01191645·14 enrolled

Remimazolam2 trials

Remimazolam Phase II Cardiac Anesthesia Study

Completed·PPaion UK Ltd.·Phase 2·NCT01937767·90 enrolled

The Comparison of Remimazolam With Propofol in Core Body Temperature

Completed·WWonkwang University Hospital·Phase 4·NCT05215834·90 enrolled

Neuropathic Pain2 trials

Influence of Anesthetic Technique on Acute and Chronic Neuropathic Pain

Completed·VVA Pittsburgh Healthcare System·Phase 4·NCT02527083·10 enrolled

Effect of Opioids in Neuropathic Pain in Postherpetic Patients

Unknown status·MMedical University of Vienna·Phase 3·NCT01102101·30 enrolled

Postoperative Analgesia1 trial

Controlled-Release Oxycodone For Postoperative Analgesia After Video-Assisted Thoracic Surgery

Terminated·UUniversity of Parma·Phase 4·NCT00681174·22 enrolled

Trial1 trial

The PATHFINDER Study: A Feasibility Trial

Completed·—·Phase 1·NCT04016740·22 enrolled

Hernia1 trial

Evaluating Pain Outcomes of Caudal vs Ilioinguinal Nerve Block in Children Undergoing Hernia Repair

Unknown status·—·N/A·NCT03041948·88 enrolled

Delirium1 trial

The Effect of Remifentanil Infusion During Emergence on the Incidence of Emergence Delirium

Unknown status·YYeungnam University College of Medicine·N/A·NCT02108795·86 enrolled

Ambulatory Surgery1 trial

Comparison of Desflurane Anesthesia Versus TIVA-TCI in Patients Undergoing Ophthalmic Ambulatory Surgery

Completed·XXiaoliang Gan·N/A·NCT02922660·209 enrolled

Muscle Relaxation1 trial

A Prospective, Multi-center, Randomized Controlled Study of Muscle Relaxation Effect and Safety of Mivacurium Chloride in Pediatric Surgery Patients

Completed·JJiangsu Nhwa Pharmaceutical Co., Ltd.·Phase 4·NCT02117401·1,152 enrolled

Pediatric Anesthesia1 trial

Pupillometry Guided Remifentanil Administration In Pediatric Anesthesia

Withdrawn·UUniversity Hospital, Geneva·N/A·NCT02683837

Intraocular Pressure1 trial

Effects Of Anaesthesia on Intraocular Pressure in Robotic Prostate Surgery

Completed·—·N/A·NCT07033442·60 enrolled

Critically Ill Patients1 trial

Population Pharmacokinetics of Remifentanil in Low-Weight Critically Ill Patients

Recruiting·FFudan University··NCT07301970·45 enrolled

Efficacy and Safety1 trial

Efficacy and Safety of Oxycodone Hydrochloride for Long-term Analgesia in ICU Patients

Not yet recruiting·SShanghai Zhongshan Hospital·Phase 4·NCT06444997·60 enrolled

Cognitive Functions1 trial

Cognitive Functions After TIVA With Dexmedetomidine

Completed·UUludag University·Phase 4·NCT02631135·40 enrolled

Post Operative Cognitive Dysfunction1 trial

Comparison of Intravenous Anesthetics to Volatile Anesthetics on Postoperative Cognitive Dysfunction

Completed·SSun Yat-sen University·Phase 4·NCT01809041·684 enrolled

Total Intravenous Anesthesia1 trial

Effect of Total Intravenous Anesthesia and Balanced Anesthesia on Postoperative Lung Function

Completed·MMedical University Innsbruck·Phase 4·NCT00706277·60 enrolled

Randomised Controlled Trial1 trial

A Randomised Controlled Trial of Remifentanil Intravenous Patient Controlled Analgesia (PCA) Versus Intramuscular Pethidine for Pain Relief in Labour

Completed·UUniversity of Birmingham·Phase 4·NCT02179294·401 enrolled

Intensive Care Unit1 trial

A Low Dose Remifentanil Infusion During Tracheal Extubation in Surgical Intensive Care Unit Patients

Completed·SSeverance Hospital·Phase 4·NCT01152515·50 enrolled

Injury1 trial

Myocardial Injury in Remifentanil-based Versus Sevoflurane-sufentanil Balanced Regimens in OPCAB Surgery

Completed·KKonkuk University Medical Center·N/A·NCT02499445·120 enrolled

Analgesic1 trial

The Effect of Analgesic Drugs on Respiratory Center

Unknown status·CChun Pan·Phase 4·NCT04372342·50 enrolled

Prostatectomy1 trial

Analysis of Change of Optic Nerve Sheath Diameter in Robot Assisted Laparoscopic Radical Prostatectomy

Completed·SSeoul National University Hospital·N/A·NCT03152981·60 enrolled

Cataract1 trial

Controlled Sedation for Cataract Surgery

Terminated·FFundación Universitaria de Ciencias de la Salud·Phase 4·NCT03401606·98 enrolled

Pilot Study1 trial

The T REX Pilot Study: a Study to Investigate the Use of an Alternative Anaesthetic in Infants.

Completed·MMurdoch Childrens Research Institute·Phase 4·NCT02353182·60 enrolled

Respiratory Distress Syndrome1 trial

Surfactant Via Endotracheal Tube vs. Laryngeal Mask Airway (LMA) in Preterm Neonates With Respiratory Distress Syndrome

Terminated·—·Phase 4·NCT02164734·93 enrolled

Epilepsy1 trial

Conscious Sedation for Epilepsy Surgery

Completed·MMenoufia University·N/A·NCT02988050·60 enrolled

Laparoscopic Cholecystectomy1 trial

LAPOFAR Trial: Opioid-Free vs. Remifentanil Anesthesia in Laparoscopic Cholecystectomy

Completed·—·N/A·NCT07307625·101 enrolled

Head and Neck1 trial

Effect of Remifentanil on the Recovery Profile After Prolonged Head and Neck Surgery

Completed·SSingapore General Hospital··NCT02416752·222 enrolled

Spine Surgery1 trial

Opioid Sparing Anesthesia in Cervical Spine Surgery

Unknown status·EEvangelismos Hospital·N/A·NCT05717361·60 enrolled

Sunburn1 trial

The Effect of High-dose Remifentanil on Established Sunburn-induced Hyperalgesia in Human Volunteers (HighDose RemiSun)

Unknown status·MMedical University of Vienna·Phase 4·NCT01015482·24 enrolled

Myocardial Protection1 trial

Myocardial Protection and Anesthetic Agents

Completed·—·Phase 4·NCT02405689·60 enrolled

Obstructive Sleep Apnea1 trial

Study of Pain Processing in Subjects Suffering From Obstructive Sleep Apnea

Completed·SStanford University··NCT00672737·56 enrolled

Cognitive Function1 trial

Remifentanil/Sufentanil for CABG+/-AVR Evaluated by Recovery, Cognitive Function, Haemodynamics and Biochemical Markers.

Completed·—·Phase 4·NCT02053818·60 enrolled

Colorectal Cancer1 trial

The Effects of General Anesthetics on Lymphocytes in Patients Undergoing Colorectal Cancer Resection and Mechanism Involved

Unknown status·GGuizhi Du··NCT03193710·260 enrolled

Post-cardiac Surgery1 trial

Remifentanil Versus Dexmedetomidine for Post-Cardiac Surgery Patients With Noninvasive Ventilation Intolerance

Completed·SShanghai Zhongshan Hospital··NCT03395886·90 enrolled

Aspiration1 trial

Opioid Induced Swallowing Difficulties and Risk for Pulmonary Aspiration

Completed·RRegion Örebro County·Phase 4·NCT01495377·25 enrolled

Laparoscopic Sleeve Gastrectomy1 trial

Anaesthesia for Laparoscopic Sleeve Gastrectomy

Completed·MMenoufia University·N/A·NCT03029715·100 enrolled

Complication1 trial

Impact of Lidocaine Administration on Postoperative Complications During Lung Resection Surgery

Completed·FFrancisco Andres de la Gala·Phase 4·NCT03905837·156 enrolled

Patient-Controlled Analgesia1 trial

Intravenous Remifentanil Patient-controlled Analgesia (PCA) and Epidural Patient Controlled Epidural Analgesia (PCEA) for Labor Analgesia

Completed·HHadassah Medical Organization·Phase 4·NCT00801047·50 enrolled

Target Controlled Infusion of Propofol1 trial

THe Comparison of Target Controlled Infusion of Propofol or Etomidate at General Anesthesia in Geriatric Patients

Unknown status·SSecond Affiliated Hospital of Xi'an Jiaotong University·Phase 4·NCT02111265·90 enrolled

Neuromuscular Blockade1 trial

Remifentanil Minimum Effective Dose for Children Intubation Without Neuromuscular Blockade

Completed·—·Phase 4·NCT02454868·30 enrolled

Patient-controlled Intravenous Analgesia1 trial

Patient-controlled Intravenous Analgesia With Remifentanil Infusion for Labour

Terminated·SSamuel Lunenfeld Research Institute, Mount Sinai Hospital·N/A·NCT01563939·2 enrolled

Local Anesthesia1 trial

Remifentanil And Local Anesthesia Compared With Local Anesthesia For The Insertion Of Central Venous Catheters

Completed·UUniversity Hospital, Toulouse·Phase 4·NCT02206022·90 enrolled

Sinus Surgery1 trial

Comparison of Metoprolol and Tramadol With Remifentanil in Endoscopic Sinus Surgery

Completed·RRecep Tayyip Erdogan University·Phase 4·NCT02484859·88 enrolled

Ketorolac1 trial

Effect of Spinal Ketorolac After Acute Opioid Exposure

Terminated·WWake Forest University·Phase 2·NCT00693160·30 enrolled

Obesity1 trial

Effects of an Opioid Free/Sparing Care Pathway for Patients Undergoing Obesity Surgery

Recruiting·GGöteborg University·N/A·NCT03756961·220 enrolled

Preoperative1 trial

New Options for Preoperative Anesthesia in Intrauterine Needling

Completed·LLeiden University Medical Center·Phase 1·NCT01013558·50 enrolled

Postoperative Recovery1 trial

The Effect of Dexmedetomidine During Opioid Free Anesthesia on Postoperative Recovery After Gastrectomy

Completed·GGangnam Severance Hospital·N/A·NCT04529135·68 enrolled

Septic Shock1 trial

Comparison of Analgesic and Sedative Effects of Esmketamine and Remifentanil Combined With Propofol Respectively in Septic Shock Patients With Invasive Mechanical Ventilation

Unknown status·TThe First Hospital of Jilin University·N/A·NCT05551910·120 enrolled

Esketamine1 trial

Remiazolam Combined With Esketamine in Painless Bidirectional Endoscopy in Children

Completed·TTongji Hospital·N/A·NCT05686863·106 enrolled

Lumbar Spine Surgery1 trial

Opioid Sparing Anesthesia in Lumbar Spine Surgery

Unknown status·—·N/A·NCT05594407·60 enrolled

Hysterectomy1 trial

Remifentanil Versus Fentanyl During Laparoscopic Hysterectomy

Unknown status·WWolfson Medical Center·N/A·NCT04178785·76 enrolled

Caesarean Delivery1 trial

Dexmedetomidine vs. Remifentanil for Pre-eclampsia During Caesarean Delivery

Completed·MMansoura University·Phase 2·NCT01766089·50 enrolled

Mechanical Ventilation1 trial

Compare the Effects of Remifentanil and Fentanyl on the Duration of Mechanical Ventilation of ICU Patients

Unknown status·—·Phase 4·NCT05014711·254 enrolled

Bradycardia1 trial

Determination of Remifentanil's ED50 for Rapid Sequence Intubation Avoiding Bradycardia and Hypotension in Adults

Completed·—·Phase 3·NCT03065309·15 enrolled

Orthognathic Surgery1 trial

Assessment of Hematologic Parameters Before and After Bimaxillary Orthognathic Surgery

Completed·FFederal University of Minas Gerais·N/A·NCT02364765·53 enrolled

Heart Rate Variability1 trial

Heart Rate Variability Under Propofol and Sevoflurane

Completed·HHôpital Armand Trousseau·N/A·NCT03098875·40 enrolled

Arteriosclerosis Obliterans1 trial

Effects of Anesthetics on Postoperative Cognitive Function of Patients Undergoing Endovascular Repair of Aortic Aneurysm and Endovascular Treatment of Arteriosclerosis Obliterans of Lower Extremities.

Completed·TTao Zhang·Phase 4·NCT02107170·68 enrolled

Opioids1 trial

Study on the Effect of a Beta Blocker on Increased Sensitivity to Pain in Humans Caused by Opioids

Completed·SStanford University·Phase 2·NCT01222091·10 enrolled

Labor Analgesia1 trial

Intravenous Remifentanil for Labor Analgesia

Completed·NNanjing Medical University·Phase 4·NCT00710086·1,000 enrolled

Induction Anesthesia1 trial

The Effect of Propofol and Remifentanil Sequence on ED50 and ED95 of Rocuronium in Rapid Sequence Induction Anesthesia

Completed·—·Phase 4·NCT02709473·84 enrolled

Treatment1 trial

Esmolol Pretreatment on Pain During Injection of Propofol

Completed·KKyungpook National University Hospital·N/A·NCT01885364·120 enrolled

Oliceridine Fumarate1 trial

Efficacy and Safety Studies of Oliceridine Fumarate

Not yet recruiting·CChun Pan·Phase 4·NCT06454292·292 enrolled

Brain Injury1 trial

Remifentanil for Sedation of Patients With Traumatic Brain Injury (TBI)

Completed·JJoseph D. Tobias··NCT02049320·38 enrolled

Surgery1 trial

Assessment of the Nociception During Lumbar Surgery

Completed·UUniversity Hospital, Grenoble·N/A·NCT01015651·16 enrolled

Depth of Anesthesia1 trial

Influence of Depth of Anesthesia on Pupillary Reactivity to a Standardized Stimulus

Completed·HHôpital Armand Trousseau·N/A·NCT02595476·12 enrolled

Spinal Fusion1 trial

Methadone vs Magnesium in Spinal Fusion

Completed·NNationwide Children's Hospital·Phase 2·NCT01795495·63 enrolled

Analgesia1 trial

Comparison of Different Analgesia-Monitors in Tracing Unconscious Pain Sensations

Completed·UUniversitätsklinikum Hamburg-Eppendorf·N/A·NCT02429960·30 enrolled

Interaction1 trial

Pharmacodynamic Interaction of REMI and DMED

Completed·UUniversity Medical Center Groningen·Phase 4·NCT03143972·30 enrolled

Unspecified2 trials

ULTIVA Post Marketing Surveillance

Completed· GSK logo

GSK··NCT01299584·775 enrolled

The Medasense Study

Completed·LLeiden University Medical Center·N/A·NCT01912118·96 enrolled

Regulatory

FDA Approval Timeline[5]

Jul 12, 1996

ULTIVA

NDA NDA020630

Jun 23, 1999

ULTIVA

NDA NDA020630

Oct 15, 1999

ULTIVA

NDA NDA020630

Nov 23, 1999

ULTIVA

NDA NDA020630

Sep 19, 2000

ULTIVA

NDA NDA020630

Nov 19, 2001

ULTIVA

NDA NDA020630

Oct 3, 2002

ULTIVA

NDA NDA020630

Dec 20, 2002

ULTIVA

NDA NDA020630

Mar 8, 2004

ULTIVA

NDA NDA020630

Jun 11, 2013

ULTIVA

NDA NDA020630

Jan 12, 2016

ULTIVA

NDA NDA020630

Dec 16, 2016

ULTIVA

NDA NDA020630

Jun 21, 2018

ULTIVA

NDA NDA020630

Oct 7, 2019

ULTIVA

NDA NDA020630

Dec 15, 2023

ULTIVA

NDA NDA020630

Dec 22, 2025

ULTIVA

NDA NDA020630

Dec 22, 2025

ULTIVA

NDA NDA020630

Sources

References

[1]
ClinicalTrials.gov — 335 trial records for Remifentanil. U.S. National Library of Medicine, National Institutes of Health.
[2]
MedlinePlus Drug Information — Ultiva drug information. U.S. National Library of Medicine, National Institutes of Health.
[3]
ChEMBL — Remifentanil compound record. European Bioinformatics Institute (EMBL-EBI).
[4]
Open Targets Platform — Drug–disease associations for Remifentanil. EMBL-EBI & Wellcome Sanger Institute.
[5]
OpenFDA — FDA approval records (NDA NDA020630). U.S. Food & Drug Administration.
[6]
SEC EDGAR — Pfizer's Upjohn has merged with Mylan to form Viatris Inc. company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Mechanism of Action: Mu Opioid Receptor Agonist[3]
Modality: Small molecule[3]
Highest Phase: Approved[1]
Company: PPfizer's Upjohn has merged with Mylan to form Viatris Inc.