Gastroenterology

Hernia

47

Pipeline Programs↗

12

Active Trials↗

21

Companies Involved↗

Hernia is a moderately active landscape with 47 programs across 21 companies. The most active players are TLC Biopharmaceuticals, Inc., Mononuclear Therapeutics Ltd., Gynecologic Oncology Group. 13 therapies are approved with 3 more in late-stage development.

Intelligence

Pipeline Metrics

Competitive Density

60/100

Pipeline Velocity

27/100

Mech. Concentration

20/100

Completion Rate

81/100

Attrition Rate

13/100

Competition

Competitive Landscape

Bubble size = clinical trials

Approved

Phase 3

Phase 2

Phase 1

Preclinical

Key Players

Top Companies

TLC Biopharmaceuticals, Inc.

1 program

Mononuclear Therapeutics Ltd.

1 program

Gynecologic Oncology Group

1 program

AlgoRx Pharmaceuticals

1 program

Protega

1 program

Sanofi

1 program

Pipeline

Programs by Phase

Analysis

Trial Status

56

clinical trials

Completed29 · 52%

Unknown status8 · 14%

Recruiting7 · 13%

Terminated4 · 7%

Active, not recruiting3 · 5%

Withdrawn3 · 5%

Other2 · 4%

Clinical Trials

Trial Activity

56 trials

A Trial of Phosphodiesterase-5 Inhibitor in Neonatal Congenital Diaphragmatic Hernia (TOP-CDH)

Recruiting·UUniversity of Utah·Phase 2·NCT05201144·40 enrolled

Surgery with Botulinum Toxin a for Incisional Hernia

Recruiting·AAssistance Publique - Hôpitaux de Paris·Phase 3·NCT06499324·260 enrolled

The Role of Antibiotic Prophylaxis in Lowering Wound Infection Rates Post-Open Repair of Primary Elective Groin Hernias in High-Risk Patients

Recruiting·UUniversity of Aleppo·Phase 3·NCT06576154·200 enrolled

De-implementing Inhaled Nitric Oxide for Congenital Diaphragmatic Hernia

Recruiting·TThe University of Texas Health Science Center, Houston·Phase 4·NCT05213676·600 enrolled

Assessment of Intra-abdominal Pressure During the Perioperative Period of Hernia Repair

Recruiting·CCentre Hospitalier Universitaire de Nice·Preclinical·NCT07531615·10 enrolled

Infant Survival and Long-term Outcome Following Fetoscopic Endoluminal Tracheal Occlusion in Severe Left and Right Congenital Diaphragmatic Hernia, A Phase III Trial

Recruiting·—·Preclinical·NCT07577414·40 enrolled

Fetal Endoscopic Tracheal Occlusion (FETO) Trial for Congenital Diaphragmatic Hernia (CDH)

Recruiting·—·Preclinical·NCT05354505·10 enrolled

Effectiveness and Safety of Korean Medicine Treatment for Cervical Disc Herniation

Active, not recruiting·JJaseng Medical Foundation·N/A·NCT03959098·120 enrolled

Post-operative Pain Control-TAP Block Using Exparel vs. Marcaine for Hernia Repairs

Active, not recruiting·—·Phase 1·NCT05177991·200 enrolled

A Retrospective, Single Centre, Observational Study to Evaluate the Safety and Effectiveness of LIQUIBAND FIX8® When Used for Mesh Fixation During Ventral Incisional Hernia Repair.

Active, not recruiting·AAdvanced Medical Solutions Ltd.·N/A·NCT07295379·148 enrolled

Efficacy of Inhaled Nitric Oxide in Congenital Diaphragmatic Hernia

Not yet recruiting·—·Phase 4·NCT07247240·40 enrolled

A Randomized Trial of Duramesh Versus PDS Loop Suture for Midline Incision Fascial Abdominal Closure Evaluation in Patients With Gynecological Malignancies

Not yet recruiting·AAristotle University Of Thessaloniki·Preclinical·NCT07683546·300 enrolled

Trigger-point Blockade in Persistent Pain After Open Groin Hernia Repair

Completed·UUniversity of Copenhagen·Phase 3·NCT02065219·20 enrolled

Drainage Versus Sealant in Double Blinded Monocentric Open Incisional Hernia Repair

Completed·UUniversity Hospital, Ghent·Phase 4·NCT00775034·57 enrolled

Study of the Efficacy of Preoperative Cefuroxime Prophylaxis to Prevent Surgical Site Infection in Herniated Disk Surgery

Completed·—·Phase 4·NCT00530400·1,369 enrolled

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Data sources: ClinicalTrials.gov (NIH) · OpenFDA (FDA) · ChEMBL (EMBL-EBI) · Open Targets (EBI/Sanger) · MedlinePlus (NIH) · PubMed (NIH) · SEC EDGAR (SEC)