VivoSeq
Other

Hypospadias

27

Pipeline Programs↗

7

Active Trials↗

11

Companies Involved↗

Hypospadias is an emerging landscape with 27 programs across 11 companies. The most active players are TLC Biopharmaceuticals, Inc., Merck & Co., McNeil Consumer & Specialty Pharmaceuticals, a Division of McNeil-PPC, Inc.. 12 therapies are approved with 6 more in late-stage development.

Intelligence

Pipeline Metrics

Competitive Density

52/100

Pipeline Velocity

11/100

Mech. Concentration

19/100

Completion Rate

83/100

Attrition Rate

7/100

Competition

Competitive Landscape

Bubble size = clinical trials

Approved
Phase 3
Phase 2
Phase 1
Preclinical

Key Players

Top Companies Companies ranked by the number of pipeline programs they run for this disease.

T

TLC Biopharmaceuticals, Inc.

1 program

Phase 1Merck & Co. logo

Merck & Co.

1 program

Phase 2M

McNeil Consumer & Specialty Pharmaceuticals, a Division of McNeil-PPC, Inc.

1 program

Phase 3K

Kenvue Brands

2 programs

ApprovedOtsuka logo

Otsuka

1 program

ApprovedM

Milestone Pharmaceuticals Inc.

1 program

Approved

Pipeline

Programs by Phase

Analysis

Trial Status

27

clinical trials

Completed10 · 37%
Unknown status8 · 30%
Recruiting4 · 15%
Not yet recruiting2 · 7%
Active, not recruiting1 · 4%
Withdrawn1 · 4%
Other1 · 4%

Clinical Trials

Trial Activity

27 trials

Caudal Anesthesia Versus Local Anesthesia in Hypospadias
Recruiting·NNecmi Kadıoğlu Hospital·N/A·NCT06417060·200 enrolled
The Effect of Caudal Block on the İncidence of Urethrocutaneous Fistula After Distal Hypospadias Repair: A Multicentre, Randomized Controlled Trial
Recruiting·SSaglik Bilimleri Universitesi Gazi Yasargil Training and Research Hospital·Preclinical·NCT07675798·80 enrolled
Improving Parental Support in Hypospadias Care
Recruiting·UUniversity of North Carolina, Chapel Hill·Preclinical·NCT06832280·324 enrolled
Prospective Comparison of Sacral Erector Spinae Plane Block and Caudal Epidural Block for Postoperative Analgesia in Pediatric Hypospadias Surgery
Recruiting·TTC Erciyes University·Preclinical·NCT07619651·60 enrolled
Prophylactic Antibiotics or Placebo After Hypospadias Repair
Active, not recruiting·—·N/A·NCT02096159·93 enrolled
Comparison of the Efficacy of Bupivacaine with and Without Dexmedetomidine As an Adjuvant on Penile Block for Postoperative Pain Relief in Pediatrics Undergoing Hypospadias Repair Surgery
Not yet recruiting·—·Phase 3·NCT06789393·80 enrolled
Preventative Effect of Combining Dexamethasone with Ondansetron on Postoperative Nausea, Vomiting and Shivering in Children Undergoing Caudal Anesthesia on Hypospadias Surgery
Not yet recruiting·—·Phase 4·NCT06747975·100 enrolled
Comparison of Caudal Block Versus Dexmedetomidine Infusion in Pediatric Patients Undergoing Hypospadias Repair Surgery
Completed·TTanta University·N/A·NCT04331418·135 enrolled
Effect of Intravenous Dexamethasone With Pudendal Nerve Block on Postoperative Pain in Pediatric Hypospadias Repair
Completed·DDr Sonia ben khalifa (PhD)·Phase 4·NCT03902249·70 enrolled
Antibiotic Use Following Distal and Mid-shaft Hypospadias Repair
Completed·MMedical College of Wisconsin·N/A·NCT02593903·67 enrolled
Caudal Combination of Dexamethasone and/or Dexmedetomidine to Bupivacaine in Pediatric Hypospadias Surgery
Completed·—·Phase 1·NCT03261921·63 enrolled
Does Caudal Block Increase the Incidence of Urethrocutaneous Fistula Formation Following Hypospadias Repair in Infants?
Completed·UUniversity of Colorado, Denver·Phase 4·NCT02861950·165 enrolled
Does the Single Use of Intravenous Dexamethasone Enhance Analgesic Quality of Pudendal Analgesia in Children Undergoing Hypospadias Surgery?
Completed·YYonsei University·N/A·NCT04836962·46 enrolled
Dexmedetomidine Infusion in Hypospadias Surgery
Completed·UUniversity of Jordan·Phase 3·NCT00926705·48 enrolled
Association of Different Doses of Clonidine in Caudal Epidural Anesthesia for Hypospadias Surgery
Completed·FFederal University of Minas Gerais·Phase 2·NCT02769390·80 enrolled
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Data sources: ClinicalTrials.gov (NIH) · OpenFDA (FDA) · ChEMBL (EMBL-EBI) · Open Targets (EBI/Sanger) · MedlinePlus (NIH) · PubMed (NIH) · SEC EDGAR (SEC)