Trimethoprim-sulfamethoxazole

ApprovedSmall molecule

Astellas

Trimethoprim-sulfamethoxazole is one of 393 small molecule programs targeting Cellulitis. It is currently in Approved.

Indications

Total Trials

Active Trials

392

Competitors

Pipeline

Status by Indication[3][1]

Indication

CellulitisActive, not recruiting

AbscessActive, not recruiting

ToxoplasmosisActive, not recruiting

PyelonephritisActive, not recruiting

LymphomaActive, not recruiting

ErythemaActive, not recruiting

Kidney TransplantActive, not recruiting

MalariaActive, not recruiting

Chronic Obstructive Pulmonary DiseaseActive, not recruiting

PneumoniaActive, not recruiting

CellulitisPreclinical

Active, not recruiting

AbscessPreclinical

Active, not recruiting

ToxoplasmosisPhase 3

Active, not recruiting

PyelonephritisPhase 3

Active, not recruiting

LymphomaPhase 2

Active, not recruiting

ErythemaApproved

Active, not recruiting

Kidney TransplantApproved

Active, not recruiting

MalariaPhase 3

Active, not recruiting

Chronic Obstructive Pulmonary DiseasePhase 3

Active, not recruiting

PneumoniaPhase 3

Active, not recruiting

Showing 10 of 19 indications

Competition

Competitive Landscape

1774 competitors in Lymphoma

#DrugCompanyPhaseTrials

Trimethoprim-sulfamethoxazole

Astellas

Approved

2 2

Norvir

AbbVie

Preclinical

1 3

Wellcovorin

GGlaxo Dba Glaxosmithkline

Preclinical

4 4

Nuvigil

NNuvo Research GmbH

Preclinical

1 5

Systemic Therapy

Bristol-Myers Squibb

Preclinical

1 6

PEG-Intron

Merck & Co.

Preclinical

1 7

Rhg-CSF

CCSPC Baike (Shandong) Biopharmaceutical Co., Ltd.

Preclinical

3 8

Stem Cells

KKang Stem Biotech Co., Ltd.

Preclinical

2 9

JY231

SShenzhen Genocury Biotech Co., Ltd.

Preclinical

1 10

PD-1 Monoclonal Antibody

SSichuan Baili Pharmaceutical Co., Ltd.

Preclinical

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q1 2027

Phase 2/3Recruiting

Antibiotic Therapy

NCT07202078

Phase 2/3Recruiting

Antibiotic Therapy

NCT07202091

Phase 2/3Recruiting

Antibiotic Therapy

NCT07202052

Q2 2027

Phase 2/3Recruiting

Antibiotic Therapy

NCT05678621

Post-ApprovalRecruiting

Infections

NCT06982105

Q4 2027

Phase 1/2Active, not recruiting

Granulomatosis With Polyangiitis

NCT03919435

Clinical

Trials by Indication[1]

Antibiotic Therapy4 trials

Role of Antibiotic Therapy or Immunoglobulin On iNfections in hAematoLogy: Starting Immunoglobulin (Start Ig)

Recruiting·MMonash University·Phase 2/3·NCT07202078·900 enrolled

Role of Antibiotic Therapy or Immunoglobulin On iNfections in hAematoLogy Immunoglobulin Stopping or Extension (Stop Ig)

Recruiting·MMonash University·Phase 2/3·NCT07202091·900 enrolled

Role of Antibiotic Therapy or Immunoglobulin On iNfections in hAematoLogy: Immunoglobulin Stopping or Extension

Recruiting·MMonash University·Phase 2/3·NCT05678621·300 enrolled

Show 1 more trial

Role of Antibiotic Therapy or Immunoglobulin On iNfections in hAematoLogy Platform Trial (RATIONAL-PT)

Recruiting·MMonash University·Phase 2/3·NCT07202052·900 enrolled

Abscess3 trials

Utility of Trimethoprim-sulfamethoxazole Use in Skin Abscess Management

Completed·SSt. Louis University·Phase 4·NCT00679302·161 enrolled

Evaluation of 3 Versus 10 Days of Antibiotics in Skin Abscesses After Surgical Drainage

Completed·—·N/A·NCT02024867·249 enrolled

Antibiotics Versus Placebo in the Treatment of Abscesses in the Emergency Department

Terminated·—·N/A·NCT00867789·140 enrolled

Malaria2 trials

Interactions Between HIV and Malaria in African Children

Completed·UUniversity of California, San Francisco·Phase 3·NCT00527800·351 enrolled

Chemopreventive Therapy for Malaria in Ugandan Children

Completed·UUniversity of California, San Francisco·Phase 3·NCT00948896·600 enrolled

Methicillin-resistant Staphylococcus Aureus2 trials

Uncomplicated Skin and Soft Tissue Infections Caused by Community-Associated Methicillin-Resistant Staphylococcus Aureus

Completed·NNational Institute of Allergy and Infectious Diseases (NIAID)·Phase 2·NCT00730028·1,310 enrolled

Randomized Clinical Trial to Compare a Regimen of Trimethoprim-sulfamethoxazole Plus Rifampicin With a Regimen of Linezolid in the Treatment of Methicillin-Resistant Staphylococcus Aureus (MRSA) Infection

Completed·UUniversity Hospital, Geneva·Phase 4·NCT00711854·150 enrolled

Antibiotics2 trials

Prophylactic Antibiotics on Urethral Catheter Withdrawal

Completed·SSt. Antonius Hospital·Phase 4·NCT00126698·100 enrolled

Strategies Using Off-Patent Antibiotics for Methicillin Resistant S. Aureus "STOP MRSA"

Completed·NNational Institute of Allergy and Infectious Diseases (NIAID)·Phase 2/3·NCT00729937·2,265 enrolled

25 more indications

Lymphoma2 trials

Combination Chemotherapy in Treating Patients With AIDS-Related Lymphoma

Completed·MM.D. Anderson Cancer Center·Phase 2·NCT00002524·46 enrolled

SWOG-9320 Combination Chemotherapy, Radiation Therapy, and Antiviral Therapy in Treating Patients With AIDS-Related Lymphoma

Completed·SSWOG Cancer Research Network·Phase 2·NCT00002571·52 enrolled

Urinary Tract Infection2 trials

Perioperative Fosfomycin in the Prophylaxis of Urinary Tract Infection in Kidney Transplant Recipients

Completed·IInstituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran·Phase 4·NCT03235947·82 enrolled

Prophylactic Antibiotics for Urinary Tract Infections After Robot-Assisted Radical Cystectomy

Completed·RRoswell Park Cancer Institute·Phase 4·NCT04502095·89 enrolled

Pneumonia2 trials

DB289 Versus TMP-SMX for the Treatment of Acute Pneumocystis Jiroveci Pneumonia (PCP)

Terminated·IImmtech Pharmaceuticals, Inc·Phase 3·NCT00302341·48 enrolled

Low Dose Trimethoprim-Sulfamethoxazole for the Treatment of Pneumocystis Jirovecii Pneumonia

Recruiting·—·Phase 3·NCT04851015·416 enrolled

Staphylococcus Aureus Bacteremia1 trial

Staphylococcus Aureus Bacteremia Antibiotic Treatment Options

Completed·HHeinrich-Heine University, Duesseldorf·Phase 3·NCT01792804·215 enrolled

Hypospadias1 trial

Prophylactic Antibiotics or Placebo After Hypospadias Repair

Active, not recruiting·—·N/A·NCT02096159·93 enrolled

Children1 trial

PK of Clindamycin and Trimethoprim-sulfamethoxazole in Infants and Children

Completed·MMichael Cohen-Wolkowiez·Phase 1·NCT02475876·51 enrolled

Pyelonephritis1 trial

Antibiotic Prophylaxis in Children With Pyelonephritis

Withdrawn·UUniversity of Alberta·Phase 3·NCT00752375

Infections1 trial

Trimethoprim-sulfamethoxazole vs. Clindamycin for the Treatment of Children With Invasive MRSA Infections

Recruiting·IIndiana University·Phase 4·NCT06982105·100 enrolled

Malignancies1 trial

Antimicrobial Solution or Saline Solution in Maintaining Catheter Patency and Preventing Catheter-Related Blood Infections in Patients With Malignancies

Withdrawn·MM.D. Anderson Cancer Center·Phase 1/2·NCT01101412

Pneumocystis1 trial

Treatment of Pneumocystis in COPD (the TOPIC Study)

Terminated·CCorewell Health East·Phase 1/2·NCT05418777·1 enrolled

Osteomyelitis1 trial

Vancomycin Or Trimethoprim/Sulfamethoxazole for Methicillin-resistant Staphylococcus Aureus Osteomyelitis

Completed·UUniversity of Washington·Phase 3·NCT00324922·2 enrolled

Age-Related Macular Degeneration1 trial

A Study of the Safety and Tolerability of ASP7317 in Senior Adults Who Are Losing Their Clear, Sharp Central Vision Due to Geographic Atrophy Secondary to Dry Age-related Macular Degeneration

Recruiting· Astellas logo

Astellas·Phase 1·NCT03178149·42 enrolled

Granulomatosis with Polyangiitis1 trial

TEMPO Study: Trimethoprim-Sulfamethoxazole in Granulomatosis With Polyangiitis

Active, not recruiting·UUniversity of Pennsylvania·Phase 1/2·NCT03919435·8 enrolled

Cellulitis1 trial

Study of New Antibiotic Regimen for the Treatment of Uncomplicated Cellulitis in Emergency Department Patients

Completed·—·N/A·NCT00676130·153 enrolled

Chronic Obstructive Pulmonary Disease1 trial

Antibiotic/COPD in Acute Exacerbation of Chronic Obstructive Pulmonary Disease (COPD) Requiring Mechanical Ventilation

Completed·UUniversity of Monastir·Phase 3·NCT00791505·170 enrolled

Antibiotic Prophylaxis1 trial

Antibiotic Prophylaxis for Transrectal Prostate Biopsy

Completed·NNorthwestern University·Phase 4·NCT01659866·563 enrolled

Acute Lymphoblastic Leukemia1 trial

Alemtuzumab and Combination Chemotherapy in Treating Patients With Untreated Acute Lymphoblastic Leukemia

Completed·NNational Cancer Institute (NCI)·Phase 1/2·NCT00061945·302 enrolled

Stenotrophomonas Maltophilia Infection1 trial

Trimethoprim-Sulfamethoxazole vs Levofloxacin as Targeted Therapy for Stenotrophomonas Maltophilia Infections: a Retrospective Cohort Study

Completed·NNational Institutes of Health Clinical Center (CC)··NCT04639817·1,621 enrolled

Cystic Fibrosis1 trial

Testing a Novel Combination Treatment (Arm D) Versus Standard of Care for Intensive Phase Treatment for Mycobacterium Abscessus Pulmonary Disease in People With or Without Cystic Fibrosis in the Finding the Optimal Regimen for Mycobacterium Abscessus Treatment (FORMaT) Adaptive Platform Trial

Not yet recruiting·TThe University of Queensland·Phase 2·NCT07485010·300 enrolled

Vesicoureteral Reflux1 trial

Randomized Intervention for Children With Vesicoureteral Reflux (RIVUR)

Completed·NNational Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)·Phase 3·NCT00405704·607 enrolled

Kidney Transplant1 trial

Antibiotics for Kidney Transplant Recipients

Not yet recruiting·UUniversity of California, San Francisco·Phase 4·NCT07106125·50 enrolled

Toxoplasmosis1 trial

Influence of Trimethoprim-Sulfamethoxazole for the Recurrence of Ocular Toxoplasmosis

Completed·UUniversity of Campinas, Brazil·Phase 3·NCT01449877·141 enrolled

Advanced or Metastatic Solid Tumors1 trial

VNP20009 in Treating Patients With Advanced or Metastatic Solid Tumors That Have Not Responded to Previous Therapy

Completed·VVion Pharmaceuticals·Phase 1·NCT00004216

Erythema1 trial

Prophylactic Trimethoprim/Sulfamethoxazole to Prevent Severe Infections in Patients With Lupus Erythematous

Unknown status·IInstituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran·Phase 4·NCT03042260·310 enrolled

Chronic Obstructive Pulmonary Disease (COPD)1 trial

A Multicenter, Prospective, Double-blind, Randomized Controlled Study on the Impact of Decolonization Treatment on the Frequency of Acute Exacerbation in Patients With Chronic Obstructive Pulmonary Disease Colonized With Pneumocystis Jirovecii

Not yet recruiting·SSecond Affiliated Hospital, School of Medicine, Zhejiang University·Preclinical·NCT07665359·630 enrolled

Sources

References

[1]
ClinicalTrials.gov — 41 trial records for Trimethoprim-sulfamethoxazole. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — Trimethoprim-sulfamethoxazole compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for Trimethoprim-sulfamethoxazole. EMBL-EBI & Wellcome Sanger Institute.
[4]
SEC EDGAR — Astellas company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[2]
Highest Phase: Approved[1]
Company: Astellas

Trimethoprim-sulfamethoxazole

Status by Indication[3][1]

Competitive Landscape

Expected Milestones

Q1 2027

Q2 2027

Q4 2027

Trials by Indication[1]

Antibiotic Therapy4 trials

Abscess3 trials

Malaria2 trials

Methicillin-resistant Staphylococcus Aureus2 trials

Antibiotics2 trials

Lymphoma2 trials

Urinary Tract Infection2 trials

Pneumonia2 trials

Staphylococcus Aureus Bacteremia1 trial

Hypospadias1 trial

Children1 trial

Pyelonephritis1 trial

Infections1 trial

Malignancies1 trial

Pneumocystis1 trial

Osteomyelitis1 trial

Age-Related Macular Degeneration1 trial

Granulomatosis with Polyangiitis1 trial

Cellulitis1 trial

Chronic Obstructive Pulmonary Disease1 trial

Antibiotic Prophylaxis1 trial

Acute Lymphoblastic Leukemia1 trial

Stenotrophomonas Maltophilia Infection1 trial

Cystic Fibrosis1 trial

Vesicoureteral Reflux1 trial

Kidney Transplant1 trial

Toxoplasmosis1 trial

Advanced or Metastatic Solid Tumors1 trial

Erythema1 trial

Chronic Obstructive Pulmonary Disease (COPD)1 trial

References

Drug Info

Quick Facts

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