VivoSeq
Cardiovascular

Hypotension

98

Pipeline Programs↗

32

Active Trials↗

33

Companies Involved↗

Hypotension is a moderately active landscape with 98 programs across 33 companies. The most active players are Regeneron, Lundbeck, EMD Serono. 45 therapies are approved with 15 more in late-stage development.

Intelligence

Pipeline Metrics

Competitive Density

71/100

Pipeline Velocity

41/100

Mech. Concentration

10/100

Completion Rate

89/100

Attrition Rate

7/100

Competition

Competitive Landscape

Bubble size = clinical trials

Approved
Phase 3
Phase 2
Phase 1
Preclinical

Key Players

Top Companies Companies ranked by the number of pipeline programs they run for this disease.

Regeneron logo

Regeneron

2 programs

Phase 2Lundbeck logo

Lundbeck

1 program

Phase 2EMD Serono logo

EMD Serono

1 program

Phase 2I

Iperboreal Pharma Srl

1 program

Phase 3P

Pfizer's Upjohn has merged with Mylan to form Viatris Inc.

2 programs

Phase 3Alnylam Pharmaceuticals logo

Alnylam Pharmaceuticals

2 programs

Approved

Pipeline

Programs by Phase

Preclinical23

Caffeine

Hikma Pharmaceuticals LLC

Metoclopramide

Istituto Clinico Humanitas

Ketamine

Aultman Health Foundation

Remifentanil

Pfizer's Upjohn has merged with Mylan to form Viatris Inc.

Ciprofol

Haisco Pharmaceutical Group Co., Ltd.

Phase 12

Ropivacaine

Fresenius Kabi Oncology Ltd.

Ketalar

Helse Møre og Romsdal HF

Phase 213

Droxidopa

Lundbeck

Bupivacaine

Innocoll

Mannitol

B. Braun Medical Inc.

Metformin

EMD Serono

Fentanyl

Cephalon

Phase 315

Icatibant

Takeda

Norepinephrine

General Hospital of Ningxia Medical University

Hydrocortisone

Pfizer's Upjohn has merged with Mylan to form Viatris Inc.

L-Carnitine

Iperboreal Pharma Srl

Norepinephrine Bitartrate

Longeveron Inc.

Approved45

Tranexamic Acid

Amring

Ivabradine

Amgen

Chlorpheniramine and Ranitidine

Mahidol University

Midodrine

Takeda

Desflurane

Baxter Healthcare Corporation

Analysis

Trial Status

183

clinical trials

Completed97 · 53%
Unknown status42 · 23%
Recruiting14 · 8%
Not yet recruiting12 · 7%
Terminated9 · 5%
Enrolling by invitation3 · 2%
Other6 · 3%

Clinical Trials

Trial Activity

183 trials

Effect of Titrated Administration of Ciprofol on Perioperative Hypotension in Elderly Patients Undergoing Laparoscopic Abdominal Surgery: A Randomized Controlled Trial
Recruiting·SSixth Affiliated Hospital, Sun Yat-sen University·N/A·NCT07328958·500 enrolled
Dopamine vs. Norepinephrine for Hypotension in Very Preterm Infants With Late-onset Sepsis
Recruiting·MMount Sinai Hospital, Canada·N/A·NCT05347238·550 enrolled
Ketamine for Preventing Post-Spinal Hypotension in Orthopedic Surgery
Recruiting·—·N/A·NCT06995690·30 enrolled
Prevention of Intradialytic Hypotension by Inhibiting Bradykinin B2 Receptor
Recruiting·VVanderbilt University Medical Center·Phase 3·NCT05834777·26 enrolled
Noradrenaline Versus Standard Blood Pressure Management for Perioperative Hypotension in Non-cardiac Surgery
Recruiting·JJagiellonian University·Phase 3·NCT06885268·750 enrolled
Effect of Dexamethasone on Post-spinal Hypotension
Recruiting·SShaheed Mohtarma Benazir Bhutto Institue of Trauma·Phase 4·NCT06819436·170 enrolled
Effect of Ciprofol on Intraoperative Hypotension in Elderly Patients Receiving Renin-angiotensin System Inhibitors
Recruiting·SSecond Affiliated Hospital, School of Medicine, Zhejiang University·Phase 4·NCT06952608·140 enrolled
Methylene Blue for the Prevention of Hypotension During Hemodialysis
Recruiting·FFederal University of São Paulo·Phase 2·NCT05092165·260 enrolled
Norepinephrine Weaning Guided by the Hypotension Prediction Index in Vasoplegic Shock After Cardiac Surgery
Recruiting·—·N/A·NCT05922982·142 enrolled
Norepinephrine on Maternal Hypotension After Combined Lumbar and Epidural Anaesthesia
Recruiting·—·Phase 4·NCT06498115·100 enrolled
Anesthesia Techniques, Neuroprotection and Surgical Field in FESS Under Controlled Hypotension
Recruiting·—·N/A·NCT07181564·150 enrolled
The Efficacy of Dexmedetomidine Versus Labetalol In Providing Controlled Hypotension In Dacryocystorhinostomy SurgeryA Comparative Randomized Prospective Study
Recruiting·SSohag University·N/A·NCT06346561·50 enrolled
Study on Preliminary Safety and Efficacy of the ARC-IM Therapy to Support Hemodynamic Management in People With Typical and Atypical Parkinson's Disease
Recruiting·EEcole Polytechnique Fédérale de Lausanne·Preclinical·NCT06920134·5 enrolled
Effectiveness of Hypotension Prediction Index (HPI) in Preventing Hypotension in the Post-Anesthesia Care Unit (PACU): A Prospective, Randomized, Controlled Trial
Recruiting·WWonkwang University Hospital·Preclinical·NCT07097454·210 enrolled
Evaluation of Post-Induction Hypotension Treatment with PRAM Method
Active, not recruiting·—·N/A·NCT06787404·100 enrolled
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Data sources: ClinicalTrials.gov (NIH) · OpenFDA (FDA) · ChEMBL (EMBL-EBI) · Open Targets (EBI/Sanger) · MedlinePlus (NIH) · PubMed (NIH) · SEC EDGAR (SEC)