Reglan

(Metoclopramide)

ApprovedSmall molecule

Metoclopramide is used to relieve nausea and vomiting, and to help food move more easily through the stomach in people with certain digestive problems.[2] Reglan is currently approved and in use across 36 indications[4].[1]

Reglan is one of 601 small molecule programs targeting Tension-type headache. It is currently in Approved.

Indications

115

Total Trials

Active Trials

600

Competitors

FDA Applications

NDA/BLA/ANDA regulatory filings

Patents

Pipeline

Status by Indication[4][1]

Indication

Tension-Type HeadacheActive, not recruiting

Gastrointestinal DiseaseActive, not recruiting

Intestinal ObstructionApproved

Migraine DisorderApproved

HIV InfectionApproved

GastroschisisApproved

GastroenteritisApproved

VertigoActive, not recruiting

HypotensionActive, not recruiting

Cesarean SectionActive, not recruiting

Tension-Type HeadacheApproved

Active, not recruiting

Gastrointestinal DiseaseApproved

Active, not recruiting

Intestinal ObstructionApproved

Approved

Migraine DisorderApproved

Approved

HIV InfectionApproved

Approved

GastroschisisApproved

Approved

GastroenteritisApproved

Approved

VertigoApproved

Active, not recruiting

HypotensionPreclinical

Active, not recruiting

Cesarean SectionPreclinical

Active, not recruiting

Showing 10 of 32 indications

Competition

Competitive Landscape

242 competitors in Efficacy and Safety

#DrugCompanyPhaseTrials

Avastin

Roche

Phase 3

11 2

Reglan

IIstituto Clinico Humanitas

Approved

1 3

Savaysa

Daiichi Sankyo

Phase 3

3 4

Fludara

Sanofi

Phase 3

1 5

Tuoyi

SSun Yat-sen University

Phase 3

4 6

Busulfex

Akero Therapeutics

Phase 3

3 7

Tyvyt

Innovent Biologics (Suzhou) Co. Ltd.

Phase 3

3 8

Kineret

SSwedish Orphan Biovitrum

Phase 3

2 9

Alka-Seltzer

AAbbott

Phase 3

1 10

Mitomycin C

GGynecologic Oncology Group

Phase 3

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q3 2026

Post-ApprovalNot yet recruiting

Efficacy

NCT07031479

Q1 2027

ApprovedRecruiting

Intraoperative

NCT07740577

Q2 2027

ApprovedRecruiting

Post Operative Nausea and Vomiting

NCT07638527

Q3 2027

ApprovedNot yet recruiting

Nausea and Vomiting

NCT06740812

Clinical

Trials by Indication[1]

Nausea and vomiting13 trials

Comparison of Ondansetron, Metoclopramide and Promethazine for the Treatment of Nausea and Vomiting in the Adult ED

Terminated·VVanderbilt University·N/A·NCT00655642·171 enrolled

Treatment Algorithm for Nausea and Vomiting in the Palliative Phase

Unknown status·RRadboud University Medical Center·Phase 4·NCT03017391·20 enrolled

Uncomplicated Nausea and Vomiting in the Emergency Department

Completed·WWellSpan Health·Phase 4·NCT00778011·137 enrolled

Show 10 more trials

Efficacy of Three Antiemetics in Preventing Nausea and Vomiting

Completed·TThe Second Affiliated Hospital of Chongqing Medical University·Phase 4·NCT05533281·200 enrolled

Prevention of Intraoperative Nausea and Vomiting During Cesarean Section

Completed·—·N/A·NCT01216410·306 enrolled

Clinical Trial to Investigate the Efficacy and Safety of Ondansetron (Danset - Adwia) Versus Placebo Plus the Standard of Care in the Treatment of Nausea and Vomiting in Adult Patients With Acute Gastroenteritis

Not yet recruiting·GGenuine Research Center, Egypt·Phase 3·NCT05876585·126 enrolled

Prophylactic Subhypnotic Propofol for Nausea and Vomiting During for Cesarean Section Under Subarachnoid Anesthesia.

Completed·GG. d'Annunzio University·Phase 4·NCT01781377·112 enrolled

Effects of Ondansetron, Metoclopramide and Granisetron on Perioperative Nausea and Vomiting in Patients Undergone Bariatric Surgery

Completed·SShahid Beheshti University of Medical Sciences·Phase 3·NCT05087615·130 enrolled

Acupuncture Point P6 Stimulation for Reduction of Nausea and Vomiting During Cesarean

Completed·RRutgers, The State University of New Jersey·Phase 4·NCT02959840·180 enrolled

Real-time Decision Support for Postoperative Nausea and Vomiting (PONV) Prophylaxis

Completed·VVanderbilt University·N/A·NCT02625181·27,034 enrolled

Capsaicin Cream as an Adjunctive Therapy for Nausea and Vomiting of Pregnancy

Completed·WWomen and Infants Hospital of Rhode Island·Phase 2·NCT05098067·30 enrolled

Olanzapine Plus Metoclopramide for the Prevention of Opioid-Induced Nausea and Vomiting

Recruiting·—·Phase 3·NCT07208305·222 enrolled

Broadening Antiemetics Research by Comparing the Effectiveness of Fosaprepitant and Metoclopramide: A Randomized Control Trial

Not yet recruiting·MMontefiore Medical Center·Approved·NCT06740812·212 enrolled

Migraine10 trials

Intravenous Ketorolac and Metoclopramide for Pediatric Migraine in the Emergency Department

Completed·UUniversity of Alberta·Phase 4·NCT01596166·56 enrolled

Corticosteroids for Acute Migraine in the Emergency Department

Completed·MMontefiore Medical Center·Phase 4·NCT02847494·220 enrolled

Diphenhydramine for Acute Migraine

Completed·MMontefiore Medical Center·Phase 4·NCT01825941·208 enrolled

Show 7 more trials

Magnesium Versus Prochlorperazine Versus Metoclopramide for Migraines

Completed·WWake Forest University Health Sciences·Phase 3·NCT05967442·157 enrolled

Intravenous Metoclopramide in the Acute Treatment of Migraine: A Double-blind, Randomized, Placebo-controlled Trial

Completed·KKocaeli University·Phase 4·NCT02314351·148 enrolled

Trial on Metoclopramide and Ketoprofen in Acute Migraine of Childhood

Withdrawn·IIRCCS Burlo Garofolo·Phase 3·NCT00557544

Metoclopramide for Migraine: A Dose Finding Study

Completed·MMontefiore Medical Center·Phase 3·NCT00682734·349 enrolled

Intravenous Metoclopramide Versus Dexketoprofen Trometamol Versus Metoclopramide+ Dexketoprofen Trometamol in Migraine

Completed·—·N/A·NCT04252521·150 enrolled

A Pilot Clinical Trial of a New Neuromodulation Device for Acute Attacks of Migraine in Children and Adolescents

Completed·UUniversity of Calgary·Phase 3·NCT05102591·22 enrolled

Efficacy of CLORazepate for the Treatment of MIGraine Attack in the Emergency Room

Terminated·AAssistance Publique - Hôpitaux de Paris·Phase 3·NCT04726592·323 enrolled

Headache9 trials

Intravenous Metoclopramide for the Treatment of Post Concussive Headache: a Randomized Placebo Controlled Trial

Unknown status·VVancouver General Hospital·N/A·NCT00237705·40 enrolled

Metoclopramide for Post-Traumatic Headache. A Pilot Study

Completed·MMontefiore Medical Center·Phase 1/2·NCT03056352·21 enrolled

Efficacy of Haloperidol vs. Metoclopramide for Treatment of Acute Headaches and Migraines in the Emergency Department

Terminated·OOhioHealth·Phase 4·NCT02972502·66 enrolled

Show 6 more trials

Treatment of Acute Migraine Headache in Children

Completed·—·Phase 2·NCT00355394·31 enrolled

Dexamethasone for Post Traumatic Headache

Completed·MMontefiore Medical Center·Phase 4·NCT04799015·162 enrolled

Haldol/Diphenhydramine Versus Metoclopramide/Diphenhydramine for Treatment of Acute Headache in the ED: A RCT

Withdrawn·UUnited States Naval Medical Center, Portsmouth·Phase 4·NCT02098499

Metoclopramide for Post Traumatic Headache

Completed·MMontefiore Medical Center·Phase 3·NCT03220958·160 enrolled

"THINK Trial: Treatment of Headache With IntraNasal Ketamine: A Randomized Controlled Trial Evaluating the Efficacy of Intranasal Ketamine Versus Standard Therapy in the Management of Primary Headache Syndromes in the Emergency Department"

Completed·—·Phase 3·NCT03081416·80 enrolled

MgSO4 vs Metoclopramide for Headache in Pregnant Women

Withdrawn·WWomen and Infants Hospital of Rhode Island·Phase 2/3·NCT00632606

Feeding Intolerance4 trials

Efficacy, Safety, and Pharmacokinetics (PK) Study of Ulimorelin in Patients With Enteral Feeding Intolerance (EFI): The PROMOTE Trial

Completed·LLyric Pharmaceuticals·Phase 2·NCT02784392·120 enrolled

TAK-954 in Critically Ill Participants With Enteral Feeding Intolerance (EFI)

Terminated· Takeda logo

Takeda·Phase 2·NCT03477903·1 enrolled

Itopride in Feeding Intolerance of Critically-ill Patients Receiving Enteral Nutrition

Unknown status·—·N/A·NCT03698292·60 enrolled

Show 1 more trial

Electrogastrography (EGC) in Premature Infants With Feeding Intolerance

Completed·NNational Center for Research Resources (NCRR)·Phase 2·NCT00008736

Efficacy4 trials

The Efficacy of B6 and Metoclopramide Combination in Comparison With the Other Antiemetics

Completed·UUniversity of Baghdad·Phase 2/3·NCT06390787·250 enrolled

Efficacy of Itopride Versus Metoclopramide in Hospitalized Medicine Patients With High Gastric Residual Volume

Not yet recruiting·—·Phase 4·NCT07031479·86 enrolled

Efficacy and Akathisia Incidence of Slow Infusion Metoclopramide

Completed·PPamukkale University·N/A·NCT01069536·140 enrolled

Show 1 more trial

Efficacy of Metoclopramide in Poor Ovarian Response IVF Patients

Recruiting·—·N/A·NCT03560583·60 enrolled

62 more indications

Gastroparesis3 trials

Multicenter Study to Evaluate the Efficacy and Safety of Metoclopramide Nasal Spray in Men With Diabetic Gastroparesis

Completed·EEvoke Pharma·Phase 3·NCT02025751·53 enrolled

Multicenter Study to Evaluate the Efficacy and Safety of Metoclopramide Nasal Spray in Women With Diabetic Gastroparesis

Completed·EEvoke Pharma·Phase 3·NCT02025725·205 enrolled

Efficacy and Safety of Metoclopramide Nasal Spray Solution in Diabetic Patients With Gastroparesis

Completed·EEvoke Pharma·Phase 2·NCT00845858·287 enrolled

Endoscopy2 trials

Study of Metoclopramide in Small Bowel Capsule Endoscopy

Completed·AAscension Health·Phase 4·NCT01630109·5 enrolled

Study to Evaluate the Efficacy of Oral Dissolving Metoclopramide Before Video Capsule Endoscopy

Terminated·WWinthrop University Hospital·N/A·NCT01631994·6 enrolled

Prevention2 trials

The CRISIS Prevention Study

Terminated·MMichael Dean·Phase 3·NCT00395161·293 enrolled

Nefopam vs Tramadol in the Prevention of Post Anaesthetic Shivering

Unknown status·LLagos State Health Service Commission·Phase 2·NCT02441673·130 enrolled

Bowel Preparation2 trials

Bowel Preparation and Prokinetics in Capsule Endoscopy

Unknown status·LLondon North West Healthcare NHS Trust·Phase 3·NCT00275184·150 enrolled

Optimization of the Bowel Preparation Regimen for the PillCam® COLON 2 Capsule Endoscopy Procedure

Completed·MMedtronic - MITG·N/A·NCT02481219·122 enrolled

Critically Ill Patients2 trials

A Randomized, Double-Blind Study to Evaluate the Safety, Tolerability, and Pharmacodynamics of a Single Dose of Intravenous TD-8954 Compared With Metoclopramide in Critically Ill Patients With Enteral Feeding Intolerance

Completed· Takeda logo

Takeda·Phase 1/2·NCT01953081·13 enrolled

A Comparative Evaluation of Mosapride Versus Metoclopramide for Enteral Feeding Intolerance in Critically Ill Patients

Not yet recruiting·—·Phase 3·NCT06826443·100 enrolled

Ondansetron2 trials

Antiemetic Efficacy of Ondansetron Versus Metoclopramide

Unknown status·HHospital General Naval de Alta Especialidad - Escuela Medico Naval·Phase 3·NCT02619201·250 enrolled

Evaluating Neostigmine Effect on Reducing Gastric Residual Volume as Compared With Metoclopramide and Ondansetron

Completed·TTanta University·Phase 2·NCT05342818·90 enrolled

Randomised Controlled Trial2 trials

Metoclopramide to Aid Establishment of Breastfeeding:a Randomised Controlled Trial

Completed·NNational University Hospital, Singapore·N/A·NCT00264719·160 enrolled

Maxolon to Improve Breastmilk Supply in Diabetic Women: a Randomised Controlled Trial

Completed·NNational University Hospital, Singapore·Phase 3·NCT00477776·160 enrolled

Critically Ill2 trials

Nutritional Adequacy Therapeutic Enhancement in the Critically Ill. The NUTRIATE Study

Terminated· GSK logo

GSK·Phase 2·NCT01934192·91 enrolled

Acupuncture Effect on Digestion in Critically Ill Post-Operative Oral and Hypo-pharyngeal Cancer Patients

Completed·—·N/A·NCT03934294·28 enrolled

Randomized Controlled Trial2 trials

Metoclopramide and the Length of First Stage of Labor , a Randomized Controlled Trial

Completed·—·Phase 4·NCT04969120·80 enrolled

Dopamine D-2 Antagonist Use in Poor Responders in IVF: a Randomized Controlled Trial

Withdrawn·MMount Sinai Hospital, Canada·N/A·NCT02262923

Age2 trials

Palliative Management of Inoperable Malignant Bowel Obstruction

Terminated·RRoswell Park Cancer Institute·Phase 2·NCT04027348·15 enrolled

Metoclopramide Versus Hyoscine Butylbromide in Shortening Duration of First Stage of Labour

Unknown status·UUwakwe Emmanuel Chijioke·Phase 1·NCT05222646·150 enrolled

Vomiting1 trial

Intrathecal Atropine vs IV Metoclopramide for Nausea & Vomiting During CS

Completed·MMansoura University·Phase 4·NCT03932578·60 enrolled

Caesarean Section1 trial

Intrathecal Levobupivacaine With Opioids for Caesarean Section

Completed·—·Phase 3·NCT01858090·93 enrolled

Pregnancy1 trial

A Cost Effective Treatment for Headache in Pregnancy When Acetaminophen Alone is Ineffective.

Completed·SSt. Louis University·N/A·NCT02295280·70 enrolled

Clozapine-induced Hypersalivation1 trial

Metoclopramide as Treatment of Clozapine-induced Hypersalivation

Completed·—·Phase 3·NCT02222220·61 enrolled

Vertigo1 trial

Comparison of Efficacy Dimenhydrinate and Metoclopramide in the Treatment of Nausea Due to Vertigo

Completed·PPamukkale University·Phase 4·NCT02253524·200 enrolled

Mechanically Ventilated Patients1 trial

Metoclopramide on Gastric Emptying in Mechanically Ventilated Patients

Completed·TTanta University·Phase 4·NCT05641051·80 enrolled

Olanzapine1 trial

Comparison of Olanzapine and Metoclopramide For Treatment Of bReakThrough Emesis

Terminated·KKarin Jordan·Phase 2·NCT01148264·23 enrolled

Knee Arthroscopy1 trial

Ultrasound-guided Blocks for Ambulatory Knee Arthroscopy

Completed·JJens Borglum Neimann·Phase 4·NCT01837394·60 enrolled

Chemotherapy-induced nausea and vomiting1 trial

MEtoclopramide, DExamethasone or Axoli to Prevent or Delay Chemotherapy-induced Nausea and Vomiting in Moderately Emetogenic Non-AC-based Chemotherapy

Completed·AAmsterdam UMC, location VUmc·Phase 3·NCT02135510·249 enrolled

Opioid1 trial

Opioid Effects on Swallowing and Esophageal Sphincter Pressure

Completed·RRegion Örebro County·Phase 4·NCT01191645·14 enrolled

Tramadol1 trial

Role of Prophylactic Metoclopramide With Tramadol in Trauma Patients

Completed·UUniversity of Malaya·Phase 2·NCT03383315·191 enrolled

Laparoscopic Sleeve Gastrectomy1 trial

Non-opioid Anesthesia Based on Thoracic Paravertebral Block During Laparoscopic Sleeve Gastrectomy

Not yet recruiting·IIVO JURISIC·N/A·NCT07084753·36 enrolled

Greater Occipital Nerve Block1 trial

Greater Occipital Nerve Block Versus Metoclopramide

Completed·MMontefiore Medical Center·Phase 4·NCT03269435·99 enrolled

Ketorolac1 trial

Valproate Versus Ketorolac Versus Metoclopramide

Completed·MMontefiore Medical Center·Phase 4·NCT01267864·330 enrolled

Azithromycin1 trial

Metoclopramide, Azithromycin, or Nondrug Pretreatment for UGIB to Reduce Second Endoscopy

Unknown status·WWaihong Chung·Phase 2·NCT03840057·435 enrolled

Ultrasound1 trial

Ultrasound Assessment of Metoclopramide's Effect on Stomach Volume in Urgent Pediatric Trauma Surgery

Not yet recruiting·—·Phase 3·NCT06793267·70 enrolled

Gastrointestinal1 trial

Metoclopramide in Upper Gastrointestinal Bleed

Unknown status·—·Phase 4·NCT05746377·60 enrolled

Trial1 trial

Metoclopramide Pilot Trial

Terminated·TThe Hospital for Sick Children·Phase 3·NCT02098915·10 enrolled

Ileus1 trial

The Effects of Combined Gum-chewing and Parenteral Metoclopramide on Post-operative Ileus

Completed·IIkechukwu Bartholomew Ulasi·Phase 4·NCT05669781·105 enrolled

Adult1 trial

A Study Evaluating the Safety, Tolerability and Pharmacokinetics of ASY202 in Healthy Adults

Completed·AAspeya Switzerland SA·Phase 1·NCT07226362·44 enrolled

Cesarean Section1 trial

Ultrasound Assessment of Metoclopramide Effect on Gastric Volume in Cesarean Section

Unknown status·—·N/A·NCT04157998·60 enrolled

Hyperemesis Gravidarum1 trial

Comparison of Gabapentin and Metoclopramide for Treating Hyperemesis Gravidarum

Completed·SState University of New York at Buffalo·Phase 2·NCT02163434·31 enrolled

Gastric Emptying1 trial

Gastric Emptying With Metoclopramide in GLP-1 Agonist Patients Undergoing Elective Surgery

Not yet recruiting·—·Phase 4·NCT07100691·80 enrolled

Acute Myocardial Infarction1 trial

Impact of Morphine Treatment on Platelet Inhibition in Acute Myocardial Infarction

Completed·UUniversity of Luebeck·Phase 4·NCT02627950·138 enrolled

Bleeding1 trial

Metoclopramide for Acute Upper GI Bleeding

Completed·KKing Chulalongkorn Memorial Hospital·Phase 4·NCT04771481·68 enrolled

Hypoglycemia1 trial

Restoration of Hypoglycemia Awareness With Metoclopramide

Recruiting·SSimon Fisher·Phase 2·NCT03970720·36 enrolled

Myelodysplastic Syndrome1 trial

Metoclopramide to Treat Anemia in Patients With Myelodysplastic Syndrome (MDS)

Withdrawn·NNational Heart, Lung, and Blood Institute (NHLBI)·Phase 2·NCT00120653

Efficacy and Safety1 trial

Efficacy and Safety of Ondansetron Versus Metaclopromide Treatment in Infants With Gastro Oesophageal Reflux

Completed·MMuhammad Aamir Latif·N/A·NCT06898268·290 enrolled

Myocardial Infarction1 trial

Effects of Morphine on Loading-dose Ticagrelor in Patients With ST-segment Elevation Myocardial Infarction

Unknown status·GGeneral Hospital of Chinese Armed Police Forces·Phase 4·NCT02913469·128 enrolled

Gastric1 trial

Effect of Metoclopramide Versus Erythromycin on on Gastric Residual Volume

Completed·—·N/A·NCT04682691·50 enrolled

Pneumonia1 trial

Metoclopramide vs Placebo for Prevention of Pneumonia in Acute Stroke

Completed·SShaheed Zulfiqar Ali Bhutto Medical University·Phase 4·NCT04873297·106 enrolled

Tension-type headache1 trial

Metoclopramide Versus Ketorolac for Tension-type Headache

Completed·MMontefiore Medical Center·Phase 4·NCT01011673·123 enrolled

Tics1 trial

Anesthetics in Rhytidoplasty - A Comparison Study

Completed·MMercy Facial Plastic Surgery Center·N/A·NCT02410460·30 enrolled

Hypotension1 trial

Midodrine for Prophylaxis Against Post Spinal Hypotension in Elderly Population

Completed·—·N/A·NCT05548985·58 enrolled

Surgical1 trial

PEP uP Protocol in Surgical Patients

Terminated·—·Phase 4·NCT02459275·36 enrolled

Upper Gastrointestinal Bleeding1 trial

Usefulness of Metoclopramide to Improve Endoscopic Visualization in Upper Gastrointestinal Bleeding

Completed·UUniversidad Autonoma de Nuevo Leon·Phase 3·NCT06297954·50 enrolled

Gastroesophageal Reflux1 trial

Methoclopramide for Gastroesophageal Reflux in Premature Infants

Completed·NNathalie Charpak·Phase 4·NCT02907632·490 enrolled

Dexamethasone1 trial

Ondansetron Plus Dexamethasone With or Without Metoclopramide as Antiemetic Prophylaxis After Receiving Cisplatin

Completed·MMahidol University·N/A·NCT01093690·162 enrolled

Exercise1 trial

The Effect of Dopamine on Pulmonary Diffusion and Capillary Blood Volume During Exercise

Completed·UUniversity of Alberta·N/A·NCT02965963·49 enrolled

Induction Chemotherapy1 trial

Study to Evaluate the Effect of Aprepitant in Children and Adolescents Receiving AML Remission Induction Chemotherapy

Unknown status·DDr Atul Sharma·Phase 3·NCT02979548·116 enrolled

Intensive Care Unit1 trial

The Effect of Prucalopride on Gastric Emptying in Intensive Care Unit Patients

Completed·—·Phase 1/2·NCT05496179·70 enrolled

Acute Mountain Sickness1 trial

Comparison of Metoclopramide and Ibuprofen for the Treatment of Acute Mountain Sickness

Completed·MMassachusetts General Hospital·N/A·NCT01522326·300 enrolled

Women1 trial

Use of an Antiemetic to Shorten the Length of Labor in Nulliparous Women

Completed·—·Phase 4·NCT01937234·250 enrolled

Side Effects1 trial

Pharmacogenetic Factors and Side Effects of Metoclopramide and Diphenhydramine

Terminated·MMatthias Schwab·Phase 1·NCT01289938·49 enrolled

Low Birth Weight1 trial

Metoclopramide Use in Very Low Birth Weight Newborns

Completed·LLondon Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's·Phase 4·NCT00242450·30 enrolled

Cesarean Delivery1 trial

Evaluating the Effect of Intravenous Dexamethasone on the Duration of Spinal Anesthesia After Cesarean Delivery

Recruiting·IIWK Health Centre·Phase 4·NCT05731960·192 enrolled

Vaccine Response Impaired1 trial

A Human Experimental Medicine Study to Assess Whether the Gut Microbiota Regulates Specific and Non-specific Immune Responses to Vaccination

Recruiting·SSouth Australian Health and Medical Research Institute·Approved·NCT06148025·348 enrolled

Post Operative Nausea and Vomiting1 trial

Time-to-first-rescue Antiemetic With Ondansetron Plus Metoclopramide Versus Dexamethasone Plus Metoclopramide for PONV Prophylaxis in Laparoscopic Cholecystectomy: a Randomized, Triple-Blind, Superiority Trial

Recruiting·FFaisalabad Medical University·Approved·NCT07638527·264 enrolled

Cataract1 trial

Efficacy of Dexamethasone Versus Metoclopramide for Prophylaxis of Nausea and Vomiting After Cataract Surgery: A Double-blind Randomized Controlled Study

Completed·AAlexandria University·Preclinical·NCT07086118·210 enrolled

Intraoperative1 trial

Comparative Effectiveness of Routine Antiemetic Prophylaxis in Nonfasted Parturients Undergoing Cesarean Sections Under Spinal Anesthesia: A Prospective Randomized Controlled Trial

Recruiting·SSanliurfa Education and Research Hospital·Approved·NCT07740577·100 enrolled

Metastatic Neuroendocrine Prostate Cancer1 trial

A Phase I, Open-label, Multi-center Exploratory Safety and Efficacy Study With PSMA, SSTR2 and GRPR Targeted Radioligand Therapy in Metastatic Neuroendocrine Prostate Cancer.

Active, not recruiting· Novartis logo

Novartis·Phase 1·NCT06379217·31 enrolled

Unspecified3 trials

The Montefiore Metoclopramide Study

Completed·MMontefiore Medical Center·Phase 4·NCT00475306·289 enrolled

Prochlorperazine vs Metoclopramide

Completed·MMontefiore Medical Center·Phase 4·NCT00364806·76 enrolled

Subcutaneous Route and Pharmacology of Metoclopramide

Completed·UUniversity Hospital, Bordeaux·Phase 3·NCT02466984·5 enrolled

Regulatory

FDA Approval Timeline[5]

Dec 30, 1980

REGLAN

NDA NDA017854

May 13, 1981

REGLAN

NDA NDA017854

May 13, 1981

REGLAN

NDA NDA017854

Nov 6, 1981

REGLAN

NDA NDA017854

Dec 9, 1981

REGLAN

NDA NDA017854

Jan 1, 1982

REGLAN

NDA NDA017862

Feb 18, 1982

REGLAN

NDA NDA017854

Feb 19, 1982

REGLAN

NDA NDA017854

Feb 25, 1982

REGLAN

NDA NDA017854

Jun 28, 1982

REGLAN

NDA NDA017854

Sep 8, 1982

REGLAN

NDA NDA017854

Sep 23, 1982

REGLAN

NDA NDA017854

Nov 12, 1982

REGLAN

NDA NDA017854

Mar 25, 1983

REGLAN

NDA NDA018821

Apr 13, 1983

REGLAN

NDA NDA017854

May 11, 1983

REGLAN

NDA NDA017854

Jul 5, 1983

REGLAN

NDA NDA017854

Jul 27, 1983

REGLAN

NDA NDA017854

May 1, 1984

REGLAN

NDA NDA017854

May 1, 1984

REGLAN

NDA NDA017854

Aug 15, 1984

REGLAN

NDA NDA017854

Sep 21, 1984

REGLAN

NDA NDA017854

Jan 18, 1985

REGLAN

NDA NDA017854

Mar 12, 1985

REGLAN

NDA NDA017854

Aug 20, 1985

REGLAN

NDA NDA017854

Oct 21, 1985

REGLAN

NDA NDA017854

Jan 16, 1986

REGLAN

NDA NDA017854

Apr 15, 1986

REGLAN

NDA NDA017854

Apr 23, 1986

REGLAN

NDA NDA017854

Oct 21, 1986

REGLAN

NDA NDA017854

May 5, 1987

REGLAN

NDA NDA017854

May 5, 1987

REGLAN

NDA NDA017854

Sep 12, 1988

REGLAN

NDA NDA017854

Feb 22, 1989

REGLAN

NDA NDA017854

Aug 31, 1992

REGLAN

NDA NDA017854

May 31, 1994

REGLAN

NDA NDA017854

Jun 24, 1996

REGLAN

NDA NDA017854

Feb 3, 1998

REGLAN

NDA NDA017854

Mar 9, 1999

REGLAN

NDA NDA017854

Jun 1, 2000

REGLAN

NDA NDA017854

Nov 7, 2001

REGLAN

NDA NDA017854

Apr 22, 2003

REGLAN

NDA NDA017854

Apr 22, 2003

REGLAN

NDA NDA017854

Apr 22, 2003

REGLAN

NDA NDA017854

Jul 26, 2004

REGLAN

NDA NDA017854

Jun 10, 2005

REGLAN ODT

NDA NDA021793

Jun 30, 2009

REGLAN

NDA NDA017854

Sep 4, 2009

REGLAN

NDA NDA017854

Sep 4, 2009

METOZOLV ODT

NDA NDA022246

Nov 18, 2010

REGLAN

NDA NDA017854

Aug 2, 2011

REGLAN

NDA NDA017854

Sep 22, 2011

REGLAN

NDA NDA017854

Jan 12, 2015

REGLAN

NDA NDA017854

Apr 17, 2015

REGLAN

NDA NDA017854

Jun 15, 2015

REGLAN

NDA NDA017854

Aug 29, 2017

REGLAN

NDA NDA017854

Jun 19, 2020

GIMOTI

NDA NDA209388

Feb 9, 2026

REGLAN

NDA NDA017854

Sources

References

[1]
ClinicalTrials.gov — 115 trial records for Metoclopramide. U.S. National Library of Medicine, National Institutes of Health.
[2]
MedlinePlus Drug Information — Reglan drug information. U.S. National Library of Medicine, National Institutes of Health.
[3]
ChEMBL — Metoclopramide compound record. European Bioinformatics Institute (EMBL-EBI).
[4]
Open Targets Platform — Drug–disease associations for Metoclopramide. EMBL-EBI & Wellcome Sanger Institute.
[5]
OpenFDA — FDA approval records (NDA NDA017854). U.S. Food & Drug Administration.
[6]
FDA Orange Book — Patent and exclusivity data for Reglan. U.S. Food & Drug Administration.
[7]
SEC EDGAR — Istituto Clinico Humanitas company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Mechanism of Action: Dopamine D2 Receptor Antagonist; Serotonin 4 (5-HT4) Receptor Agonist; Serotonin 3a (5-Ht3a) Receptor Antagonist[3]
Modality: Small molecule[3]
Highest Phase: Approved[1]
Company: IIstituto Clinico Humanitas

Patent Landscape[6]

Patent Cliff

Dec 22, 2029

Earliest patent expiration — generic entry possible after this date

Patent #Expires

11813231Dec 22, 2029

12194009Dec 22, 2029

12194008Dec 22, 2029

11020361Dec 22, 2029

11628150Dec 22, 2029

2 more patents

8334281May 16, 2030

12377064Nov 17, 2038