Midodrine Hydrochloride

ApprovedSmall molecule

Midodrine Hydrochloride is one of 158 small molecule programs targeting Orthostatic Hypotension. It is currently in Approved.

Indications

Total Trials

Active Trials

157

Competitors

Pipeline

Status by Indication[3][1]

Indication

Orthostatic HypotensionActive, not recruiting

CognitionActive, not recruiting

Vasovagal SyncopeActive, not recruiting

Septic ShockActive, not recruiting

HypotensionActive, not recruiting

Spinal Cord InjuryActive, not recruiting

Orthostatic HypotensionApproved

Active, not recruiting

CognitionApproved

Active, not recruiting

Vasovagal SyncopePhase 3

Active, not recruiting

Septic ShockPhase 3

Active, not recruiting

HypotensionPhase 2/Phase 3

Active, not recruiting

Spinal Cord InjuryPhase 2

Active, not recruiting

Competition

Competitive Landscape

224 competitors in Septic Shock

#DrugCompanyPhaseTrials

Midodrine Hydrochloride

Takeda

Approved

1 2

Primaxin

Pfizer

Preclinical

2 3

Intropin

Pfizer

Preclinical

2 4

Zyvox

Pfizer

Preclinical

1 5

Doribax

Spravato

2 7

Cubicin

BBaxter Healthcare Corporation

Preclinical

1 8

Glucophage

EMD Serono

Preclinical

1 9

Lipitor

PPfizer's Upjohn has merged with Mylan to form Viatris Inc.

Preclinical

1 10

Avastin

BBio-Thera Solutions

Preclinical

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Clinical

Trials by Indication[1]

Orthostatic Hypotension4 trials

A Study for Patients With Neurogenic Orthostatic Hypotension

Completed· Takeda logo

Takeda·Phase 4·NCT00046475·140 enrolled

Treatment of Orthostatic Hypotension in SCI

Recruiting·JJames J. Peters Veterans Affairs Medical Center·Phase 4·NCT05839652·25 enrolled

Study to Assess the Benefit of Midodrine in the Treatment of Patients With Neurogenic Orthostatic Hypotension

Completed· Takeda logo

Takeda·Phase 4·NCT00555880·24 enrolled

Show 1 more trial

A Phase IV Study in Subjects With Neurogenic Orthostatic Hypotension

Terminated· Takeda logo

Takeda·Phase 4·NCT00046163·150 enrolled

Trial2 trials

A Dose Response Trial Using 5 and 10 Mg of Midodrine Hydrochloride

Completed·JJames J. Peters Veterans Affairs Medical Center·Phase 2·NCT00426842·11 enrolled

RaGuS Trial by Postoperative Patients

Unknown status·BBürgerspital Solothurn·Phase 4·NCT04440085·50 enrolled

Vasovagal syncope2 trials

Midodrine and Fludrocortisone for Vasovagal Syncope

Unknown status·TTehran Heart Center·Phase 3·NCT04595942·1,375 enrolled

Assessment of Midodrine in the Prevention of Vasovagal Syncope: The Prevention of Syncope Trial IV

Active, not recruiting·—·Phase 4·NCT01456481·134 enrolled

Prevention1 trial

Midodrine Versus Albumin for Prevention of Paracentesis Induced Circulatory Disturbance

Completed·—·Phase 3·NCT05240391·50 enrolled

Spinal Cord Injury1 trial

The Effects of Normalizing Blood Pressure on Cerebral Blood Flow in Hypotensive Individuals With Spinal Cord Injury

Completed·JJames J. Peters Veterans Affairs Medical Center·Phase 2·NCT02893553·21 enrolled

4 more indications

APL1 trial

Body Temperature in Persons With Tetraplegia When Exposed to Cold

Completed·JJames J. Peters Veterans Affairs Medical Center·Phase 4·NCT01822535·30 enrolled

Hypotension1 trial

Treatment of Post-SCI Hypotension

Completed·JJames J. Peters Veterans Affairs Medical Center·Phase 2/3·NCT02919917·66 enrolled

Cognition1 trial

Thermoregulation and Cognition During Cool Ambient Exposure in Tetraplegia

Completed·JJames J. Peters Veterans Affairs Medical Center·Phase 4·NCT02379156·30 enrolled

Septic Shock1 trial

Midodrine Use in Septic Shock

Terminated·UUniversity of Virginia·Phase 3·NCT03706053·10 enrolled

Sources

References

[1]
ClinicalTrials.gov — 14 trial records for Midodrine Hydrochloride. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — Midodrine Hydrochloride compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for Midodrine Hydrochloride. EMBL-EBI & Wellcome Sanger Institute.
[4]
SEC EDGAR — Takeda company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[2]
Highest Phase: Approved[1]
Company: Takeda

Midodrine Hydrochloride

Status by Indication[3][1]

Competitive Landscape

Trials by Indication[1]

Orthostatic Hypotension4 trials

Trial2 trials

Vasovagal syncope2 trials

Prevention1 trial

Spinal Cord Injury1 trial

APL1 trial

Hypotension1 trial

Cognition1 trial

Septic Shock1 trial

References

Drug Info

Quick Facts

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