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Other/Knee Arthroplasty

Knee Arthroplasty

38

Pipeline Programs↗

52

Active Trials↗

23

Companies Involved↗

Knee Arthroplasty is a moderately active landscape with 38 programs across 23 companies. 2 programs are in Phase 3.

Intelligence

Pipeline Metrics

Competitive Density

62/100

Pipeline Velocity

49/100

Mech. Concentration

17/100

Completion Rate

88/100

Attrition Rate

8/100

Pipeline

Programs by Phase

Preclinical33

Intra Thecal Morphine

University College Hospital Galway

Intrathecal Fentanyl

Mansoura University

Intrathecal Morphine

Pacira Pharmaceuticals, Inc

Intra-Articular Tranexamic Acid

Idlib University

Lidocaine

MEDRx USA, Inc.

Phase 1

No programs

Phase 23

Losartan

Organon and Co

Epidiolex

Jazz Pharmaceuticals

IO Administration of Cefazolin

The Methodist Hospital Research Institute

Phase 32

Liposomal Bupivacaine

TLC Biopharmaceuticals, Inc.

Standard Care Pain Medicines

Endeavor Health

Approved

No programs

Analysis

Trial Status

354

clinical trials

Completed205 · 58%

Unknown status68 · 19%

Recruiting31 · 9%

Withdrawn16 · 5%

Not yet recruiting15 · 4%

Terminated13 · 4%

Other6 · 2%

Clinical Trials

Trial Activity

354 trials

Local Infiltration Analgesia Versus Quadruple Nerve Blocks in Total Knee Arthroplasty: a Randomized Controlled Trial.

Recruiting·CCMC Ambroise Paré·Preclinical·NCT07477730·80 enrolled

Does Joint Immobilization Following Revision Total Knee Arthroplasty (rTKA) Improve Range of Motion Following Surgery?

Recruiting·HHospital for Special Surgery, New York·Preclinical·NCT07552415·170 enrolled

Enhancing Functional Outcomes in Total Knee Arthroplasty: the Role of Preoperative Genicular Radiofrequency

Recruiting·Anesthesiology department Iris South Hospitals·Preclinical·NCT07727551·44 enrolled

Evaluation of the Effects of Regional Anesthesia Methods Applied in Total Knee Arthroplasty on Joint Range of Motion in the Postoperative Period and Patient Satisfaction

Recruiting·KKonya City Hospital·Preclinical·NCT07124494·30 enrolled

The Impact of a Daily Whole Food Plant-based Smoothie Utilization 2 Weeks Prior to Revision Total Knee Replacement Surgery on Inflammation and Post-operative Pain.

Recruiting·HHospital for Special Surgery, New York·Preclinical·NCT06896240·24 enrolled

An Oral Methylprednisolone Taper Within a Multimodal Analgesic Regimen After Total Knee Arthroplasty: a Double-Blind Randomized Placebo-Controlled Trial

Recruiting·RRush University Medical Center·Approved·NCT05097976·420 enrolled

Total Intravenous Anesthesia vs Spinal Anesthesia in Patients Undergoing Unilateral Primary Total Knee Arthroplasty

Recruiting·UUniversity of Chicago·Preclinical·NCT07672301·150 enrolled

A Prospective, Randomized Trial Utilizing Methadone in the Management of Post-Operative Pain in Total Knee Replacement

Recruiting·AAdventHealth·Approved·NCT07485803·192 enrolled

VTE Prevention Following Total Hip and Knee Arthroplasty

Recruiting·—·Phase 3·NCT04075240·5,400 enrolled

The Perioperative Outcome of Epinephrine Infusion and Tranexamic Acid in Knee Arthroplasty Surgery

Recruiting·KKing Abdullah International Medical Research Center·Phase 4·NCT07089251·80 enrolled

Impact of Dexamethasone Route on Pain and Inflammation in iPACK With ACB for Knee Arthroplasty

Recruiting·PPoznan University of Medical Sciences·Phase 4·NCT07180953·90 enrolled

Dexamethasone Vs. Dexmedetomidine for ESPB in Pain Management After Knee Arthroplasty

Recruiting·PPoznan University of Medical Sciences·Phase 4·NCT06470100·90 enrolled

Comparing Different Doses of Corticosteroids in Local Infiltration Analgesia (LIA) for Total Knee Arthroplasty

Recruiting·FFirst Affiliated Hospital of Fujian Medical University·N/A·NCT07337772·120 enrolled

Reducing Perioperative Oxidative Stress to Prevent Postoperative Chronic Pain Following Total Knee Arthroplasty

Recruiting·VVanderbilt University Medical Center·Phase 4·NCT06083480·148 enrolled

Efficacy and Safety of Liposomal Bupivacaine Using Periarticular Injection in Total Knee Arthroplasty

Recruiting·—·Phase 4·NCT06557018·60 enrolled

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Data sources: ClinicalTrials.gov (NIH) · OpenFDA (FDA) · ChEMBL (EMBL-EBI) · Open Targets (EBI/Sanger) · MedlinePlus (NIH) · PubMed (NIH) · SEC EDGAR (SEC)