VivoSeq
Other

Total Knee Arthroplasty

174

Pipeline Programs↗

41

Active Trials↗

56

Companies Involved↗

Total Knee Arthroplasty is a highly competitive landscape with 174 programs across 56 companies. The most active players are Bayer, ScinnoHub Pharmaceutical Co., Ltd., Sanofi. 81 therapies are approved with 21 more in late-stage development.

Intelligence

Pipeline Metrics

Competitive Density

79/100

Pipeline Velocity

45/100

Mech. Concentration

16/100

Completion Rate

87/100

Attrition Rate

9/100

Competition

Competitive Landscape

Bubble size = clinical trials

Approved
Phase 3
Phase 2
Phase 1
Preclinical

Key Players

Top Companies Companies ranked by the number of pipeline programs they run for this disease.

Bayer logo

Bayer

2 programs

Phase 2S

ScinnoHub Pharmaceutical Co., Ltd.

2 programs

Phase 2Sanofi logo

Sanofi

2 programs

Phase 2M

Medtronic Spinal and Biologics

1 program

Phase 2Shanghai Hengrui Pharmaceutical Co., Ltd. logo

Shanghai Hengrui Pharmaceutical Co., Ltd.

1 program

Phase 2L

Livzon Pharmaceutical Group Inc.

1 program

Phase 2

Pipeline

Programs by Phase

Preclinical38

Duloxetine

Alnylam Pharmaceuticals

Lidocaine

MEDRx USA, Inc.

EXPAREL

Pacira Pharmaceuticals, Inc

Dexmedetomidine

McNeil Consumer & Specialty Pharmaceuticals, a Division of McNeil-PPC, Inc.

Propofol

Fresenius Kabi Oncology Ltd.

Phase 16

Losartan

Organon and Co

PLG0206

Peptilogics

Kräuterblut

Northern Orthopaedic Division, Denmark

Ferrofumerat

Northern Orthopaedic Division, Denmark

Hemoboost

Northern Orthopaedic Division, Denmark

Phase 228

Enoxaparin

Sanofi

Dexketoprofen Trometamol

Menarini

Apixaban

Bristol-Myers Squibb

Acetylsalicylic Acid

Bayer

Du-176b

Daiichi Sankyo

Phase 321

Platelet Rich Plasma

Zagazig University

Etoricoxib

Novartis

Ibuprofen

Kenvue Brands

Paracetamol

GSK

REGN7508

Regeneron

Approved81

Dexamethasone

Aspen Global Incorporated

Celecoxib

Philadelphia Eye Associates

Fentanyl

Cephalon

Hydrocortisone

Pfizer's Upjohn has merged with Mylan to form Viatris Inc.

Pantoprazole

Wyeth-Lederle Vaccines

Analysis

Modality Breakdown

98%

Small molecule

269 of 274 classified programs — the dominant modality here.

2%ALL OTHERSMonoclonal antibody2<1%Protein / enzyme1<1%Peptide1<1%Cell therapy1<1%

Small molecule leads; the ring shows all 274 classified programs, each share of the total. Modality classified for 100% of 276 pipeline programs.

Analysis

Trial Status

316

clinical trials

Completed182 · 58%
Unknown status65 · 21%
Recruiting23 · 7%
Withdrawn16 · 5%
Not yet recruiting13 · 4%
Terminated12 · 4%
Other5 · 2%

Clinical Trials

Trial Activity

316 trials

Comparing Different Doses of Corticosteroids in Local Infiltration Analgesia (LIA) for Total Knee Arthroplasty
Recruiting·FFirst Affiliated Hospital of Fujian Medical University·N/A·NCT07337772·120 enrolled
Reducing Perioperative Oxidative Stress to Prevent Postoperative Chronic Pain Following Total Knee Arthroplasty
Recruiting·VVanderbilt University Medical Center·Phase 4·NCT06083480·148 enrolled
Efficacy and Safety of Liposomal Bupivacaine Using Periarticular Injection in Total Knee Arthroplasty
Recruiting·—·Phase 4·NCT06557018·60 enrolled
Effects of Oral Tranexamic Acid Following Total Knee Arthroplasty
Recruiting·—·Phase 2·NCT06479161·80 enrolled
Analgesic Efficacy of Different Liposomal Bupivacaine Doses in the Adductor Canal Block for Total Knee Arthroplasty
Recruiting·TThe University of Hong Kong·Phase 3·NCT06740214·177 enrolled
Comparison of Postoperative Pain Score Between Perioperative Intravenous Ketamine and Placebo in Patients Undergoing Unilateral Total Knee Arthroplasty Under General Anesthesia
Recruiting·Ministry of Health, Thailand·Phase 4·NCT06267638·100 enrolled
Study on BT-114143 Reducing Perioperative Bleeding in Total Knee Arthroplasty（TKA）
Recruiting·SScinnoHub Pharmaceutical Co., Ltd.·Phase 2·NCT07127042·270 enrolled
Phase II Clinical Study of H001 Capsule in the Prevention of Venous Thromboembolism After Total Knee Arthroplasty
Recruiting·LLivzon Pharmaceutical Group Inc.·Phase 2·NCT06963320·320 enrolled
Combined Intrathecal Dexmedetomidine and Adductor Canal Block for Analgesia After Total Knee Arthroplasty
Recruiting·KKafrelsheikh University·N/A·NCT06837844·75 enrolled
ZYNRELEF for Pain Management in Total Knee Arthroplasty
Recruiting·BBaptist Health South Florida·Phase 4·NCT05644496·242 enrolled
Cannabidiol for Postoperative Opioid Reduction in Primary Total Knee Arthroplasty
Recruiting·—·Phase 2·NCT06234631·380 enrolled
Continuous Versus Single Injection Adductor Canal Blocks for Outpatient Total Knee Arthroplasty
Recruiting·UUniversity of California, San Diego·Phase 4·NCT06784882·40 enrolled
Tranexamic Acid Use on Pain, Mobility and Bleeding Following Total Hip and Total Knee Arthroplasty
Recruiting·SSt. Mary's Research Center, Canada·N/A·NCT06208267·210 enrolled
Effect of peRiopErative duLoxetIne Administration on Opioid Consumption Following Total kneE Arthroplasty (RELIFE)
Recruiting·SSunnybrook Health Sciences Centre·Phase 4·NCT06423716·150 enrolled
Oral Steroid Taper After Total Knee Arthroplasty
Recruiting·—·Phase 1·NCT07070882·130 enrolled
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Data sources: ClinicalTrials.gov (NIH) · OpenFDA (FDA) · ChEMBL (EMBL-EBI) · Open Targets (EBI/Sanger) · MedlinePlus (NIH) · PubMed (NIH) · SEC EDGAR (SEC)