VivoSeq
Neurology

Traumatic Brain Injury

3

Pipeline Programs↗

14

Active Trials↗

5

Companies Involved↗

Traumatic Brain Injury is an early-stage landscape with 3 programs across 5 companies. The most active players are Fresenius Kabi Oncology Ltd., McNeil Consumer & Specialty Pharmaceuticals, a Division of McNeil-PPC, Inc., Mario Negri Institute for Pharmacological Research.

Intelligence

Pipeline Metrics

Competitive Density

36/100

Pipeline Velocity

32/100

Mech. Concentration

67/100

Completion Rate

100/100

Attrition Rate

0/100

Competition

Competitive Landscape

Bubble size = clinical trials

Approved
Phase 3
Phase 2
Phase 1
Preclinical

Key Players

Top Companies Companies ranked by the number of pipeline programs they run for this disease.

F

Fresenius Kabi Oncology Ltd.

1 program

PreclinicalM

McNeil Consumer & Specialty Pharmaceuticals, a Division of McNeil-PPC, Inc.

1 program

PreclinicalMario Negri Institute for Pharmacological Research logo

Mario Negri Institute for Pharmacological Research

0 programs

PreclinicalRoche logo

Roche

0 programs

PreclinicalR

Ramon Diaz-Arrastia

0 programs

Preclinical

Pipeline

Programs by Phase

Analysis

Trial Status

18

clinical trials

Recruiting10 · 56%
Completed4 · 22%
Not yet recruiting4 · 22%

Clinical Trials

Trial Activity

18 trials

CoMBat Insomnia: A Randomized Controlled Trial of Cognitive-Behavioral vs. Mindfulness-Based Treatment for TBI-Related Insomnia and Post-Traumatic Stress Symptoms
Recruiting·JJohns Hopkins University·Preclinical·NCT05663034·360 enrolled
A Combined Retrospective and Prospective Study of Surgical and Clinical Outcomes in Pediatric Patients With Extradural Hematoma Following Acute Head Injury
Recruiting·SSohag University·N/A·NCT07696598·30 enrolled
Facilitation as a Strategy for Implementing the Novel TBI-RECOVER Intervention Into Substance Use Treatment: A Mixed Methods Hybrid Type 2 Effectiveness-Implementation Trial
Recruiting·OOhio State University·Preclinical·NCT07215221·900 enrolled
Study of Pathological and Regenerative Molecular and Cellular Processes Triggered After Traumatic Brain Injury: Analysis of Biopsy Specimens
Recruiting·Mario Negri Institute for Pharmacological Research logoMario Negri Institute for Pharmacological Research·N/A·NCT07683169·500 enrolled
Cerebral Autoregulation, Brain Perfusion, and Neurocognitive Outcomes After Traumatic Brain Injury
Recruiting·UUniversity of Texas Southwestern Medical Center·N/A·NCT06480838·130 enrolled
A Multicenter Prospective Study to Develop a Blood-based Biomarker Test for Aiding the Diagnosis/Prognosis of Traumatic Brain Injury in Adult Subjects (CLIN12.1) and for Monitoring the Development of Secondary Events in Patients Diagnosed With Traumatic Brain Injury (CLIN12.2)
Recruiting·Roche logoRoche·N/A·NCT07455136·2,000 enrolled
A Sleep Intervention to Improve Quality of Life and Symptom Management in Veterans With the Polytrauma Clinical Triad
Recruiting·VVA Office of Research and Development·Preclinical·NCT06477796·96 enrolled
A Feasibility Study Exploring Emotional Health Training After Moderate to Severe Traumatic Brain Injury
Recruiting·HHackensack Meridian Health·Preclinical·NCT07624825·48 enrolled
The Biomarkers in the Hyperbaric Oxygen Brain Injury Treatment Trial (BioHOBIT)
Recruiting·UUniversity of Michigan·N/A·NCT04855396·150 enrolled
Prevalence of Brain Health Versus Neurodegeneration in Former Professional Football Players
Recruiting·DDavid Okonkwo, MD, PhD·N/A·NCT04708613·300 enrolled
The Systemic Nature of Severe Traumatic Brain Injury: Multi-Omic Analysis of Neural Trauma, Autoantibodies and the Gut-Brain Axis: The MANTRA Study
Not yet recruiting·CCorewell Health West·N/A·NCT07679126·40 enrolled
Effect of Propofol, Midazolam, and Dexmedetomidine on Intracranial Pressure and Clinical Outcomes in Patients With Moderate-to-Severe Traumatic Brain Injury Undergoing Urgent Neurosurgical Intervention
Not yet recruiting·AAswan University·Preclinical·NCT07678216·210 enrolled
Investigating the Feasibility and Translational Therapeutic Benefits of Overground, Fully Immersive Virtual Reality (VR) Gait Rehabilitation Therapies for Individuals With Traumatic Brain Injury (TBI)
Not yet recruiting·IIndiana University·Preclinical·NCT07038889·30 enrolled
Assessment of Traumatic Brain Injury Using Transcranial Magnetic Stimulated Evoked Potentials (TMS-EEG)
Not yet recruiting·—·N/A·NCT06963775·215 enrolled
Evaluation, Pathogenesis, and Outcome of Subjects With or Suspected Traumatic Brain Injury
Completed·National Institute of Neurological Disorders and Stroke (NINDS)·N/A·NCT01132937·886 enrolled
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Data sources: ClinicalTrials.gov (NIH) · OpenFDA (FDA) · ChEMBL (EMBL-EBI) · Open Targets (EBI/Sanger) · MedlinePlus (NIH) · PubMed (NIH) · SEC EDGAR (SEC)