BoNT-A

Phase 2Small molecule

SSir Run Run Shaw Hospital

BoNT-A is one of 174 small molecule programs targeting Spasticity. It is currently in Phase 2.

Indications

Total Trials

Active Trials

173

Competitors

Pipeline

Status by Indication[3][1]

Indication

SpasticityActive, not recruiting

Carpal Tunnel SyndromeActive, not recruiting

TremorActive, not recruiting

Brain InjuryActive, not recruiting

MigraineActive, not recruiting

Overactive BladderActive, not recruiting

Premature EjaculationActive, not recruiting

SpasticityPreclinical

Active, not recruiting

Carpal Tunnel SyndromePhase 2

Active, not recruiting

TremorPhase 2

Active, not recruiting

Brain InjuryPhase 2

Active, not recruiting

MigrainePhase 2

Active, not recruiting

Overactive BladderPhase 2

Active, not recruiting

Premature EjaculationPreclinical

Active, not recruiting

Competition

Competitive Landscape

357 competitors in Migraine

#DrugCompanyPhaseTrials

Aimovig

Amgen

Preclinical

33 2

BoNT-A

SSir Run Run Shaw Hospital

Phase 2

1 3

Vyepti

Lundbeck

Preclinical

12 4

Savella

AbbVie

Preclinical

2 5

Botox

RRevance Therapeutics, Inc.

Preclinical

9 6

Adempas

Bayer

Preclinical

1 7

Viagra

VViatris Specialty LLC

Preclinical

2 8

Nitrostat

VViatris Specialty LLC

Preclinical

2 9

Vibramycin

PPfizer's Upjohn has merged with Mylan to form Viatris Inc.

Preclinical

1 10

Pristiq

PPrism Pharmaceuticals

Preclinical

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q3 2026

Phase 2Recruiting

Brain Injury

NCT06293300

Clinical

Trials by Indication[1]

Spasticity2 trials

Efficacy of Extracorporeal Shock Wave Therapy on Spasticity

Completed·KKayseri City Hospital·N/A·NCT06225024·40 enrolled

The Effectiveness of Early Botulinum Toxin A Injection for Lower Limbs Spasticity in Subacute Stroke Adults

Unknown status·SSir Run Run Shaw Hospital·Phase 4·NCT02505802·30 enrolled

Carpal Tunnel Syndrome1 trial

BotulInum Toxin Type A for Peripheral Neuropathic Pain in subjEcts With Carpal Tunnel Syndrome

Unknown status·FFrancesco Bono·Phase 2·NCT05411900·164 enrolled

Migraine1 trial

"Follow the Sutures". A New Procedure for Injection of Botulinum Toxin for Chronic Migraine

Completed·NNorwegian University of Science and Technology·Phase 2·NCT03543254·20 enrolled

Overactive Bladder1 trial

Different Injection Number of the Same Dose of Botulinum Toxin A on Overactive Bladder Syndrome

Completed·—·Phase 2·NCT01657409·90 enrolled

Treatment1 trial

Study Comparing Treatment With Alluzience vs Reconstituted Toxin

Completed·GGalderma R&D·Phase 4·NCT05277337·150 enrolled

3 more indications

Premature Ejaculation1 trial

Dual-Site Botulinum Toxin Type A Injection for Lifelong Premature Ejaculation

Completed·—·N/A·NCT07426640·150 enrolled

Brain Injury1 trial

Understanding and Treating Traumatic Brain Injury (TBI) Associated Photophobia With Botulinum Toxin Type A (BoNT-A)

Recruiting·UUniversity of Miami·Phase 2·NCT06293300·50 enrolled

Tremor1 trial

Kinematic-guided BoNT-A Treatment for ET and PD Tremor

Unknown status·WWestern University, Canada·Phase 2·NCT02427646·54 enrolled

Sources

References

[1]
ClinicalTrials.gov — 9 trial records for BoNT-A. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — BoNT-A compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for BoNT-A. EMBL-EBI & Wellcome Sanger Institute.
[4]
SEC EDGAR — Sir Run Run Shaw Hospital company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[2]
Highest Phase: Phase 2[1]
Company: SSir Run Run Shaw Hospital

BoNT-A

Status by Indication[3][1]

Competitive Landscape

Expected Milestones

Q3 2026

Trials by Indication[1]

Spasticity2 trials

Carpal Tunnel Syndrome1 trial

Migraine1 trial

Overactive Bladder1 trial

Treatment1 trial

Premature Ejaculation1 trial

Brain Injury1 trial

Tremor1 trial

References

Drug Info

Quick Facts

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