Ethyol
(Amifostine)ApprovedSmall molecule
Amifostine is used to reduce side effects from radiation and chemotherapy treatments in cancer patients, particularly to protect against kidney damage and reduce dry mouth after head and neck radiation.[2] Ethyol is currently approved and in use across 11 indications[4].[1]
Ethyol is one of 311 small molecule programs targeting Multiple Myeloma. It is currently in Approved.
11
Indications
20
Total Trials
0
Active Trials
310
Competitors
1
FDA Application
NDA/BLA/ANDA regulatory filings
Pipeline
Status by Indication[4][1]
Indication
Showing 10 of 11 indications
Competition
Competitive Landscape
348 competitors in Prostate Cancer
#DrugCompanyPhaseTrials
1Ethyol
LLegacy Health System
Approved
Yervoy
Bristol-Myers SquibbPhase 3
Zoladex
TTerSera Therapeutics LLC
Phase 3
Cabometyx
Bristol-Myers SquibbPhase 3
Truqap
AstraZenecaPhase 3
Docetaxel /m²
AstraZenecaPhase 3
Semaglutide Pen Injector
UUniversitaire Ziekenhuizen KU Leuven
Phase 3
Gnrh Agonist/antagonist
NNorthwestern University
Phase 3
Trexall
Jazz PharmaceuticalsPreclinical
Duragesic
CCephalon
Preclinical
Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.
Clinical
Trials by Indication[1]
Head and Neck Cancer3 trials
Lymphoma2 trials
Amifostine for Head and Neck Irradiation in Lymphoma
Completed·—·Phase 2·NCT00136474·75 enrolled
Peripheral Neuropathy1 trial
Autologous Stem Cell Transplantation1 trial
High Dose Chemotherapy With Amifostine and Autologous Stem Cell Transplantation for High Risk Relapsed Pediatric Solid Tumors and Brain Tumors
Terminated·—·Phase 2·NCT05167370·2 enrolled
12 more indications
Trigeminal Neuralgia1 trial
Squamous Cell Carcinoma1 trial
Toxicity1 trial
Nasopharyngeal Cancer1 trial
Cervical Cancer1 trial
Non-Small Cell Lung Cancer1 trial
Anemia1 trial
Phase I Study of Amifostine in Patients With Bone Marrow Failure Related to Fanconi's Anemia
Unknown status·—·Phase 1·NCT00006127·21 enrolled
Randomized1 trial
Randomized Amifostine For SCCHN
Completed·—·Phase 2·NCT00095927·58 enrolled
Cytoreductive Surgery1 trial
Locally-advanced Rectal Cancer1 trial
Unspecified1 trial
High-dose ICE With Amifostine
Completed·—·Phase 2·NCT00003657·24 enrolled
Regulatory
FDA Approval Timeline[5]
Sep 10, 1999
ETHYOL
NDA NDA020221
Sources
References
- [1]
- [2]MedlinePlus Drug Information — Ethyol drug information. U.S. National Library of Medicine, National Institutes of Health.
- [3]
- [4]Open Targets Platform — Drug–disease associations for Amifostine. EMBL-EBI & Wellcome Sanger Institute.
- [5]
- [6]
Details
Drug Info
Quick Facts
- Modality
- Small molecule[3]
- Highest Phase
- Approved[1]
- Company
- LLegacy Health System