Trexall

(Methotrexate)

ApprovedSmall molecule

Methotrexate is used to treat certain cancers, autoimmune diseases like rheumatoid arthritis and psoriasis, and to prevent rejection after organ transplants. It works by slowing down the growth of rapidly dividing cells in the body.[2] Trexall is currently approved and in use across 188 indications[4].[1]

Trexall is one of 2616 small molecule programs targeting Glioma. It is currently in Approved.

188

Indications

1,186

Total Trials

Active Trials

2,615

Competitors

FDA Applications

NDA/BLA/ANDA regulatory filings

Patents

Pipeline

Status by Indication[4][1]

Indication

GliomaActive, not recruiting

Head and Neck CarcinomaActive, not recruiting

ChoriocarcinomaActive, not recruiting

EpendymomaActive, not recruiting

Gestational Trophoblastic NeoplasmApproved

Metabolic SyndromeActive, not recruiting

Relapsing PolychondritisActive, not recruiting

HIV InfectionActive, not recruiting

Systemic Lupus ErythematosusApproved

Cardiovascular DiseaseApproved

GliomaPhase 3

Active, not recruiting

Head and Neck CarcinomaPhase 3

Active, not recruiting

ChoriocarcinomaApproved

Active, not recruiting

EpendymomaPreclinical

Active, not recruiting

Gestational Trophoblastic NeoplasmApproved

Approved

Metabolic SyndromeApproved

Active, not recruiting

Relapsing PolychondritisPhase 2

Active, not recruiting

HIV InfectionPhase 1

Active, not recruiting

Systemic Lupus ErythematosusApproved

Approved

Cardiovascular DiseaseApproved

Approved

Showing 10 of 188 indications

Competition

Competitive Landscape

2828 competitors in Breast Cancer

#DrugCompanyPhaseTrials

Trexall

Alnylam Pharmaceuticals

Approved

43 2

Tykerb

GSK

Preclinical

80 3

Trodelvy

Gilead

Preclinical

37 4

Avastin

Prolia

14 6

Lexiscan

Astellas

Preclinical

1 7

Voltaren

Novartis

Preclinical

1 8

Acupan

YYonsei University

Preclinical

1 9

Lipegfilgrastim

Merck & Co.

Preclinical

1 10

Citalopram Hydrobromide

TTorrent Pharmaceuticals Limited

Preclinical

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q4 2026

Phase 1/2Recruiting

Acute Lymphoblastic Leukemia

NCT06207123

Phase 3Recruiting

Acute Leukemia

NCT04314219

Q1 2027

Phase 2Active, not recruiting

Acute Lymphoblastic Leukemia

NCT00792948

Phase 2Active, not recruiting

Acute Lymphoblastic Leukemia

NCT02143414

Phase 1/2Active, not recruiting

Acute Lymphoblastic Leukemia

NCT05192889

Phase 2Recruiting

Acute Lymphoblastic Leukemia

NCT04747912

Clinical

Trials by Indication[1]

Rheumatoid Arthritis29 trials

A Study of Ocrelizumab in Combination With Methotrexate in Patients With Rheumatoid Arthritis Who Are Naive to Methotrexate (FILM)

Terminated· Roche logo

Roche·Phase 3·NCT00485589·613 enrolled

A Dose-Range Finding Study for ALX-0061 Combination Therapy in Subjects With Rheumatoid Arthritis

Completed·AAblynx, a Sanofi company·Phase 2·NCT02309359·345 enrolled

Methotrexate Polyglutamate Levels as a Marker for the Clinical Outcome in the Treatment of Rheumatoid Arthritis

Completed·LLudwig-Boltzmann Institut fuer Rheumatologie, Balneologie und Rehabilitation·Phase 4·NCT00695188·19 enrolled

Show 26 more trials

A Non-Comparative Study to Assess the Safety of MabThera (Rituximab) in Patients With Rheumatoid Arthritis.

Completed· Roche logo

Roche·Phase 3·NCT00502996·246 enrolled

Long-term Treatment Study of Certolizumab Pegol (CDP870) as Add-on Medication to Methotrexate in Japanese Rheumatoid Arthritis (RA) Patients

Completed· Astellas logo

Astellas·Phase 3·NCT00851318·285 enrolled

To Evaluate Sarilumab - SAR153191 (REGN88) - Auto-injector Device In Patients With Rheumatoid Arthritis

Completed· Sanofi logo

Sanofi·Phase 3·NCT02057250·217 enrolled

Evaluating Etanercept Use in Patients With Moderate to Severe Rheumatoid Arthritis Who Have Lost Response to Adalimumab

Terminated· Amgen logo

Amgen·Phase 4·NCT01927757·90 enrolled

Efficacy and Safety of Resveratrol in Patients With Rheumatoid Arthritis.

Recruiting·—·N/A·NCT07089381·118 enrolled

A Study of RO7123520 to Evaluate the Safety and Efficacy in Participants With Moderately To Severely Active Rheumatoid Arthritis (RA) Who Are Inadequately Responding to Anti-Tumor Necrosis Factor (TNF)-Alpha Therapy

Terminated· Roche logo

Roche·Phase 2·NCT03001219·109 enrolled

Efficacy and Safety Study of Abatacept Subcutaneous Plus Methotrexate in Inducing Remission in Adults With Very Early Rheumatoid Arthritis

Completed· Bristol-Myers Squibb logo

Bristol-Myers Squibb·Phase 3·NCT01142726·511 enrolled

A Study Comparing Upadacitinib (ABT-494) Monotherapy to Methotrexate (MTX) Monotherapy in Adults With Rheumatoid Arthritis (RA) Who Have an Inadequate Response to MTX (SELECT-MONOTHERAPY)

Completed· AbbVie logo

AbbVie·Phase 3·NCT02706951·648 enrolled

A Study of Retreatment With Rituximab in Patients With Rheumatoid Arthritis Receiving Background Methotrexate

Completed· Roche logo

Roche·Phase 3·NCT00266227·559 enrolled

Safety and Tolerability of Rituxan With Methotrexate and Etanercept or Methotrexate and Adalimumab in Patients With Active Rheumatoid Arthritis

Terminated· Biogen logo

Biogen·Phase 2·NCT00298272·54 enrolled

A Study of Tocilizumab as Monotherapy and in Combination With Methotrexate Versus Methotrexate in Patients With Early Moderate to Severe Rheumatoid Arthritis

Completed· Roche logo

Roche·Phase 3·NCT01007435·1,162 enrolled

A Study to Evaluate the Efficacy, Safety and Pharmacokinetics/Pharmacodynamics (PK/PD) of Ocrelizumab in Patients With Rheumatoid Arthritis

Terminated· Roche logo

Roche·Phase 2·NCT00779220·152 enrolled

An Efficacy and Safety Study of Infliximab in Participants With Rheumatoid Arthritis

Completed· Johnson & Johnson logo

Johnson & Johnson·Phase 4·NCT00896168·234 enrolled

Phase IIB Rheumatoid Arthritis Dose Ranging Study for BMS-945429 in Subjects Who Are Not Responding to Methotrexate

Completed· CSL Behring logo

CSL Behring·Phase 2·NCT01373151·418 enrolled

Long-term Efficacy of Iguratimod Alone or Iguratimod in Combination With Methotrexate in Patients With Rheumatoid Arthritis

Unknown status· Jiangsu Simcere Pharmaceutical Co., Ltd. logo

Jiangsu Simcere Pharmaceutical Co., Ltd.·Phase 4·NCT01548001·910 enrolled

A Study of RoActemra/Actemra (Tocilizumab) With or Without Methotrexate in Patients With Mild to Moderate Rheumatoid Arthritis With an Inadequate Response to Methotrexate

Completed· Roche logo

Roche·Phase 3·NCT01587989·77 enrolled

Adalimumab in Combination With Methotrexate vs Methotrexate Alone in Early Rheumatoid Arthritis

Completed·AAbbott·Phase 3·NCT00234845·148 enrolled

A Study on The Safety of Administering Rituximab at A More Rapid Rate in Patients With Rheumatoid Arthritis

Completed· Roche logo

Roche·Phase 4·NCT01382940·351 enrolled

The Efficacy and Safety of Fang yi Qing Feng Shi Granules in Subjects With Rheumatoid Arthritis

Completed·MMaoxiang Group Jilin Pharmaceutical Co., Ltd.·Phase 2·NCT02029599·240 enrolled

Extension Study to Assess the Efficacy and Safety of Repeat Treatment With Rituximab (MabThera) in Participants With Active Rheumatoid Arthritis (RA)

Completed· Roche logo

Roche·Phase 2·NCT02093026·465 enrolled

Namilumab vs Adalimumab in Participants With Moderate to Severe Early Rheumatoid Arthritis Inadequately Responding to Methotrexate

Terminated· Takeda logo

Takeda·Phase 2·NCT02393378·7 enrolled

A Study to Evaluate the Safety and Efficacy of MabThera (Rituximab) in Combination With Methotrexate (MTX) in Participants With Active Rheumatoid Arthritis Who Failed on Anti-Tumor Necrosis Factor Alpha Therapy

Completed· Roche logo

Roche·Phase 3·NCT00468546·520 enrolled

Comparative Clinical Trial of Efficacy and Safety of BCD-055 and Remicade® in Combination With Methotrexate in Patients With Active Rheumatoid Arthritis

Completed·BBiocad·Phase 3·NCT02762838·426 enrolled

Comparison of Compliance and Evolution of Functional Capacity of Patients With Rheumatoid Arthritis Treated by Methotrexate Either by Auto-injector or by Conventional Sub-cutaneous Syringe

Completed·NNordic Pharma SAS·Phase 3·NCT02553018·278 enrolled

Safety and Efficacy of MK-8457 and Methotrexate (MTX) in Participants With Active Rheumatoid Arthritis Despite MTX Therapy (P08683, MK-8457-008)

Terminated· Merck & Co. logo

Merck & Co.·Phase 2·NCT01569152·82 enrolled

A Study of MabThera (Rituximab) in Patients With Rheumatoid Arthritis Who Have Had an Inadequate Response to Methotrexate

Completed· Roche logo

Roche·Phase 4·NCT00934648·15 enrolled

Acute Lymphoblastic Leukemia26 trials

Trial Treating Relapsed Acute Lymphoblastic Leukemia With Venetoclax and Navitoclax

Active, not recruiting·SSt. Jude Children's Research Hospital·Phase 1/2·NCT05192889·35 enrolled

Carfilzomib and Hyper-CVAD in Treating Patients With Newly Diagnosed Acute Lymphoblastic Leukemia or Lymphoma

Completed·MMehrdad Abedi, MD·Phase 1·NCT02293109·10 enrolled

Blinatumomab and Combination Chemotherapy or Dasatinib, Prednisone, and Blinatumomab in Treating Older Patients With Acute Lymphoblastic Leukemia

Active, not recruiting·NNational Cancer Institute (NCI)·Phase 2·NCT02143414·53 enrolled

Show 23 more trials

Calaspargase Pegol or Pegaspargase and Combination Chemotherapy in Treating Younger Patients With Newly Diagnosed High-Risk Acute Lymphoblastic Leukemia

Completed·CChildren's Oncology Group·Phase 3·NCT00671034·166 enrolled

Risk-Adapted Chemotherapy in Treating Younger Patients With Newly Diagnosed Standard-Risk Acute Lymphoblastic Leukemia or Localized B-Lineage Lymphoblastic Lymphoma

Active, not recruiting·CChildren's Oncology Group·Phase 3·NCT01190930·9,350 enrolled

German Multicenter Trial for Treatment of Elderly Patients With Newly Diagnosed Acute Lymphoblastic Leukemia

Completed·GGoethe University·Phase 4·NCT00198978·377 enrolled

Tagraxofusp and Low-Intensity Chemotherapy for the Treatment of CD123 Positive Relapsed or Refractory Acute Lymphoblastic Leukemia or Lymphoblastic Lymphoma

Terminated·MM.D. Anderson Cancer Center·Phase 1/2·NCT05032183·4 enrolled

A Study to Investigate LP-118, Ponatinib, Vincristine and Dexamethasone in Relapsed/Refractory Acute Lymphoblastic Leukemia (ALL) or Lymphoblastic Lymphoma (LBL)

Recruiting·UUniversity of Chicago·Phase 1/2·NCT06207123·15 enrolled

PETHEMA LAL-RI/96: Treatment for Patients With Standard Risk Acute Lymphoblastic Leukemia

Completed·PPETHEMA Foundation·Phase 4·NCT00494897·374 enrolled

Combination Chemotherapy and Dasatinib in Treating Participants With Philadelphia Positive or BCR-ABL Positive Acute Lymphoblastic Leukemia.

Completed·MM.D. Anderson Cancer Center·Phase 2·NCT00390793·107 enrolled

Trial for Treatment of Adult Patients With Standard Risk Acute Lymphoblastic Leukemia With Chemotherapy and Rituximab

Completed·JJohann Wolfgang Goethe University Hospital·Phase 4·NCT00199004·60 enrolled

Combination Chemotherapy With or Without Blinatumomab in Treating Patients With Newly Diagnosed BCR-ABL-Negative B Lineage Acute Lymphoblastic Leukemia

Active, not recruiting·NNational Cancer Institute (NCI)·Phase 3·NCT02003222·488 enrolled

Combination Chemotherapy With or Without Donor Stem Cell Transplant in Treating Patients With Acute Lymphoblastic Leukemia

Active, not recruiting·NNational Cancer Institute (NCI)·Phase 2·NCT00792948·97 enrolled

Ruxolitinib Phosphate or Dasatinib With Chemotherapy in Treating Patients With Relapsed or Refractory Philadelphia Chromosome-Like Acute Lymphoblastic Leukemia

Terminated·MM.D. Anderson Cancer Center·Phase 2·NCT02420717·11 enrolled

Chemotherapy With or Without Imatinib and/or Peripheral Stem Cell Transplant in Acute Lymphoblastic Leukemia

Completed·GGruppo Italiano Malattie EMatologiche dell'Adulto·Phase 2·NCT00458848·470 enrolled

Combination Chemotherapy in Treating Young Patients With Acute Lymphoblastic Leukemia

Unknown status·UUniversitätsklinikum Hamburg-Eppendorf·N/A·NCT00343369·550 enrolled

Chemotherapy in Treating Patients With Acute Lymphoblastic Leukemia and Diffuse Non-Hodgkin's Lymphoma

Completed·NNational Institutes of Health Clinical Center (CC)·Phase 2·NCT00018954

Pegaspargase and Combination Chemotherapy in Treating Patients With Newly Diagnosed Acute Lymphoblastic Leukemia

Terminated·OOHSU Knight Cancer Institute·Phase 2·NCT01005914·11 enrolled

Dasatinib Combined With Chemotherapy in Philadelphia Chromosome-positive Acute Lymphoblastic Leukemia

Completed·IInstitute of Hematology & Blood Diseases Hospital, China·Phase 2·NCT02523976·30 enrolled

Study of Chemotherapy-Free Induction Regimen for Ph+ Acute Lymphoblastic Leukemia With Inotuzumab Ozogamicin (InO)

Recruiting·UUniversity of Chicago·Phase 2·NCT04747912·25 enrolled

Treosulfan, Fludarabine Phosphate, and Total-Body Irradiation Before Donor Stem Cell Transplant in Treating Patients With High-Risk Acute Myeloid Leukemia, Myelodysplastic Syndrome, Acute Lymphoblastic Leukemia

Completed·FFred Hutchinson Cancer Center·Phase 2·NCT00860574·96 enrolled

Combination Chemotherapy With or Without Donor Bone Marrow Transplantation in Treating Infants With Previously Untreated Acute Lymphoblastic Leukemia

Completed·CChildren's Oncology Group·Phase 2·NCT00022126·6 enrolled

EZN-3042 Administered With Re-induction Chemotherapy in Children With Relapsed Acute Lymphoblastic Leukemia (ALL)

Terminated·TTherapeutic Advances in Childhood Leukemia Consortium·Phase 1·NCT01186328·6 enrolled

Therapy for Newly Diagnosed Patients With B-Cell Precursor Acute Lymphoblastic Leukemia and Lymphoma

Recruiting·SSt. Jude Children's Research Hospital·Phase 2·NCT06533748·128 enrolled

Combination Chemotherapy With or Without Lestaurtinib in Treating Younger Patients With Newly Diagnosed Acute Lymphoblastic Leukemia

Completed·CChildren's Oncology Group·Phase 3·NCT00557193·218 enrolled

A Study of Ponatinib Versus Imatinib in Adults With Acute Lymphoblastic Leukemia

Active, not recruiting· Takeda logo

Takeda·Phase 3·NCT03589326·245 enrolled

Methotrexate11 trials

Methotrexate and Etoposide Infusions Into the Fourth Ventricle in Children with Recurrent Posterior Fossa Brain Tumors

Completed·TThe University of Texas Health Science Center, Houston·Phase 1·NCT02905110·3 enrolled

Methotrexate Infusion Into the Fourth Ventricle in Children With Malignant Fourth Ventricular Brain Tumors: A Pilot Study

Completed·MM.D. Anderson Cancer Center·Phase 1·NCT01737671·7 enrolled

Targeted Treatment Early With Etanercept + Methotrexate vs.T2T Care for DMARD-naïve Early RA Patients Based on naïve T-cell Stratification

Unknown status·UUniversity of Leeds·Phase 4·NCT03813771·106 enrolled

Show 8 more trials

Treatment of Early RA: Minocycline in Combination With Methotrexate vs Methotrexate Alone

Completed·UUniversity of Nebraska·Phase 3·NCT00579644·91 enrolled

Vinblastine and Methotrexate in Children With Pulmonary Vein Stenosis

Completed·—·Phase 2·NCT00215046·28 enrolled

Study of the Response and Cardiorespiratory Endurance in Early RA Patients Treated With Tocilizumab or Methotrexate

Completed·PPatrick Durez·N/A·NCT01245452·30 enrolled

Methotrexate Compared With Dactinomycin in Treating Patients With Gestational Trophoblastic Neoplasia

Completed·GGynecologic Oncology Group·Phase 3·NCT00003702·240 enrolled

A 30-month Follow-up of MERINO Participants to Evaluate Long-term Effects of Methotrexate in Erosive Hand OA.

Enrolling by invitation·—··NCT06281184·108 enrolled

Thyroid Associated Orbitopathy Treatment by Methotrexate Against Triamcinolone Periocular Injections

Completed·—·Phase 2·NCT05429450·18 enrolled

A Study to Investigate BMS-986165 and Methotrexate in Healthy Male Patients

Completed· Bristol-Myers Squibb logo

Bristol-Myers Squibb·Phase 1·NCT03402087·30 enrolled

A Study Investigating Interactions Between BMS-986322 and Rosuvastatin, Metformin and Methotrexate in Healthy Participants

Completed· Bristol-Myers Squibb logo

Bristol-Myers Squibb·Phase 1·NCT05615012·76 enrolled

Lymphoma10 trials

R-CHOP Combined With Lenalidomide in the First-line Treatment for Patients With Diffuse Large B Cell Lymphoma

Completed·HHenan Cancer Hospital·Phase 2·NCT04214626·60 enrolled

Combination Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Patients With Newly Diagnosed Aggressive Non-Hodgkin's Lymphoma

Completed·SSwiss Cancer Institute·Phase 3·NCT00003215·400 enrolled

Chidamide Combined With PECM in Relapsed or Refractory Peripheral T-cell Lymphoma (PTCL)

Unknown status·SSun Yat-sen University·Phase 2·NCT03321890·102 enrolled

Show 7 more trials

MESA Versus ESA in the Treatment of Early Stage NK/T-cell Lymphoma

Unknown status·RRuijin Hospital·Phase 3·NCT02631239·256 enrolled

Ibrutinib With Methotrexate and Temozolomide for Patients With Newly Diagnosed Primary CNS Lymphoma

Unknown status·HHuiqiang Huang·Phase 2·NCT04514393·33 enrolled

Study of AMG 531 to Evaluate the Safety & Efficacy in Patients With Non-Hodgkin's Lymphoma

Completed·MM.D. Anderson Cancer Center·Phase 1/2·NCT00299182·50 enrolled

Combination Chemotherapy in Treating Children With Non-Hodgkin's Lymphoma

Completed·UUNICANCER·Phase 3·NCT00003650·179 enrolled

Combination Chemotherapy, Rituximab, and Ixazomib Citrate in Treating Patients With Non-Hodgkin Lymphoma

Unknown status·NNorthwestern University·Phase 1/2·NCT02481310·38 enrolled

Rituximab and Combination Chemotherapy in Treating Patients With Newly Diagnosed Primary CNS Lymphoma

Completed·AAlliance for Clinical Trials in Oncology·Phase 2·NCT00098774·47 enrolled

A Phase III Randomized Trial of Low-Dose Versus Standard-Dose mBACOD Chemotherapy With rGM-CSF for Treatment of AIDS-Associated Non-Hodgkin's Lymphoma

Completed·NNational Institute of Allergy and Infectious Diseases (NIAID)·Phase 3·NCT00000658·250 enrolled

Breast Cancer10 trials

Combination Chemotherapy With Trastuzumab in Treating Women With Metastatic Breast Cancer

Completed·EEuropean Organisation for Research and Treatment of Cancer - EORTC·Phase 2·NCT00036868·90 enrolled

A Study of Cyclophosphamide/Methotrexate/5-Fluorouracil (CMF) With Pegfilgrastim in Subjects With Breast Cancer

Completed· Amgen logo

Amgen·Phase 2·NCT00124111

ZD6474 (Zactima) and Metronomic Chemotherapy in Advanced Breast Cancer

Completed·—·Phase 1·NCT00496665·25 enrolled

Show 7 more trials

Bevacizumab With or Without Cyclophosphamide and Methotrexate: A Pilot Study in Women With Operable Breast Cancer

Completed·—·N/A·NCT00121134·164 enrolled

Tamoxifen Following Combination Chemotherapy in Treating Women With Operable Invasive Breast Cancer

Completed·SScottish Cancer Therapy Network·Phase 3·NCT00002579·2,000 enrolled

Combination Chemotherapy in Treating Women With Stage III Breast Cancer

Suspended·GGrupo Oncologico Cooperativo del Sur·Phase 3·NCT00002696

Sunitinib, Cyclophosphamide, and Methotrexate in Treating Patients With Metastatic Breast Cancer

Terminated·UUniversity of California, San Francisco·Phase 1/2·NCT00616122·32 enrolled

Combination Chemotherapy and Filgrastim Before Surgery in Treating Patients With HER2-Positive Breast Cancer That Can Be Removed By Surgery

Completed·UUniversity of Washington·Phase 2·NCT00194779·50 enrolled

ELDA: Elderly Breast Cancer - Docetaxel in Adjuvant Treatment

Completed·NNational Cancer Institute, Naples·Phase 3·NCT00331097·300 enrolled

A Pilot Trial of Sequential Chemotherapy With Antimetabolite Induction, High-Dose Alkylating Agent Consolidation With Peripheral Blood Progenitor Cell Support, and Intensification With Paclitaxel and Doxorubicin for Patients With High-Risk Breast Cancer

Completed·NNational Cancer Institute (NCI)·Phase 2·NCT00001498·55 enrolled

76 more indications

Psoriasis7 trials

Dose Response and Safety Study of Topical Methotrexate for the Treatment of Fingernail Psoriasis

Unknown status·MMediQuest Therapeutics·Phase 2·NCT00666354·83 enrolled

Study Evaluating Etanercept and Methotrexate in Plaque Psoriasis

Completed· Pfizer logo

Pfizer·Phase 4·NCT00161655·60 enrolled

Comparative Effectiveness of Psoriasis Treatments on Systemic Inflammation

Completed·UUniversity Hospitals Cleveland Medical Center··NCT02330380·26 enrolled

Show 4 more trials

MAP Study: Methotrexate and Adalimumab in Psoriasis

Completed·JJeffrey J Crowley MD·Phase 2/3·NCT03217734·56 enrolled

Outcomes With Treatment and Withdraw of Ixekizumab in Patients With Plaque Psoriasis

Recruiting·SSingapore General Hospital·Phase 4·NCT04537689·40 enrolled

Dose Ranging Study to Compare the Efficacy and Safety of Methotrexate in Plaque Type Psoriasis

Completed·PPost Graduate Institute of Medical Education and Research, Chandigarh·Phase 4·NCT01187264·100 enrolled

The Efficacy and Safety of Adding Methotrexate to Etanercept in Psoriasis

Completed· Amgen logo

Amgen·Phase 3·NCT01001208·478 enrolled

Central Nervous System Lymphoma7 trials

Combination Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Patients With Newly Diagnosed Central Nervous System Lymphoma

Completed·MMemorial Sloan Kettering Cancer Center·Phase 2·NCT00003632·30 enrolled

Rituximab, Methotrexate, Vincristine Sulfate, Procarbazine Hydrochloride, and Cytarabine With or Without Radiation Therapy in Treating Patients With Primary Central Nervous System Lymphoma

Completed· Radiation Therapy Oncology Group logo

Radiation Therapy Oncology Group·Phase 2·NCT01399372·91 enrolled

Rituximab, Lenalidomide Combined With Methotrexate and Temozolomide For Primary Central Nervous System Lymphoma

Recruiting·HHenan Cancer Hospital·Phase 2·NCT04737889·30 enrolled

Show 4 more trials

Temozolomide in Treatment of Patients With Primary Central Nervous System Lymphoma

Unknown status·GGuangdong Provincial People's Hospital·Phase 2·NCT02934204·51 enrolled

LTA Pilot Study of Glucarpidase in Patients With Central Nervous System Lymphoma

Active, not recruiting·MMemorial Sloan Kettering Cancer Center·Phase 1·NCT03684980·58 enrolled

A Study of Pomadomide in Combination With Rituximab and Methotrexate for Newly-diagnosed Primary Central Nervous System Lymphoma

Recruiting·SSecond Affiliated Hospital, School of Medicine, Zhejiang University·Phase 1/2·NCT06554561·43 enrolled

Orelabrutinib,Rituximab and Methotrexate in Newly Diagnosed Primary Central Nervous System Lymphoma

Recruiting·SSecond Affiliated Hospital, School of Medicine, Zhejiang University·Phase 2·NCT05600660·28 enrolled

Leukemia6 trials

Monoclonal Antibody Therapy, Cyclophosphamide, and Total-Body Irradiation Followed by Peripheral Stem Cell Transplantation in Treating Patients With Advanced Recurrent Acute Lymphocytic Leukemia

Completed·FFred Hutchinson Cancer Center·Phase 2·NCT00003870·40 enrolled

Clofarabine With Cytarabine for Patients With Minimal Residual Disease Positive Leukemia

Terminated·TTherapeutic Advances in Childhood Leukemia Consortium·Phase 2·NCT01158885·2 enrolled

Combination Chemotherapy in Treating Patients With Non-Hodgkin's Lymphoma or Acute Lymphocytic Leukemia

Completed·AAlliance for Clinical Trials in Oncology·Phase 2·NCT00002494·134 enrolled

Show 3 more trials

Combination Chemotherapy in Treating Patients With Relapsed or Refractory Acute Lymphocytic Leukemia

Unknown status·HHannover Medical School·Phase 2·NCT00002532

Combination Chemotherapy in Treating Patients With Acute B-Lymphoblastic Leukemia or Non-Hodgkin's Lymphoma

Completed·MMemorial Sloan Kettering Cancer Center·Phase 2·NCT00002471

A Study of Revumenib in Combination With Chemotherapy for Patients Diagnosed With Relapsed or Refractory Leukemia

Active, not recruiting·CChildren's Oncology Group·Phase 2·NCT05761171·78 enrolled

Mantle Cell Lymphoma4 trials

R-MACLO-IVAM and Thalidomide in Untreated Mantle Cell Lymphoma

Completed·UUniversity of Miami·Phase 2·NCT00450801·22 enrolled

Combination Chemotherapy in Treating Patients With Newly Diagnosed Mantle Cell Lymphoma

Completed·MM.D. Anderson Cancer Center·Phase 2·NCT00003311·19 enrolled

Rituximab and Combination Chemotherapy in Treating Patients With Previously Untreated Mantle Cell Lymphoma

Completed·UUniversity of Miami·Phase 2·NCT00878254·25 enrolled

Show 1 more trial

Ofatumumab in Combination With Cyclophosphamide, Doxorubicin Hydrochloride, Vincristine Sulfate, and Dexamethasone Alternating With Ofatumumab in Combination With Cytarabine and Methotrexate in Treating Patients With Newly Diagnosed Mantle Cell Lymphoma

Completed·RRoswell Park Cancer Institute·Phase 2·NCT01527149·37 enrolled

Graft Versus Host Disease3 trials

Study to Assess the Safety and Efficacy of Tacrolimus (Prograf Capsule/Injection) and Methotrexate (MTX) Combination Therapy for Prevention of Graft Versus Host Disease (GVHD) in Patients Who Received Peripheral Hematopoietic Stem Cell Transplantation From a Sibling Donor

Completed· Astellas logo

Astellas·Phase 4·NCT02660684·39 enrolled

Calcineurin Inhibitor-Free Interventions BMT CTN 1301 for Prevention of Graft-versus-Host Disease (BMT CTN 1301)

Completed·NNational Heart, Lung, and Blood Institute (NHLBI)·Phase 3·NCT02345850·346 enrolled

Prevention of Graft-Versus-Host Disease in Patients With Hematologic Malignancies Who Are Receiving a Bone Marrow Transplant

Withdrawn·FFred Hutchinson Cancer Center·Phase 1/2·NCT00002790

Treatment3 trials

LAL-BR/2001: Study Treatment to Low Risk ALL

Completed·PPETHEMA Foundation·Phase 4·NCT00526175·150 enrolled

Treatments Against RA and Effect on FDG-PET/CT

Completed·—·Phase 4·NCT02374021·159 enrolled

Immune Modulation During Palynziq® Treatment in Adults (IMPALA)

Not yet recruiting· BioMarin Pharmaceutical logo

BioMarin Pharmaceutical·Phase 4·NCT07477691·12 enrolled

Stem Cell Transplant3 trials

Donor Peripheral Stem Cell Transplant in Treating Patients With Advanced Hematologic Cancer or Other Disorders

Active, not recruiting·—·Phase 2·NCT00544115·260 enrolled

Early Administration of ATG Followed by Cyclophosphamide, Busulfan and Fludarabine Before a Donor Stem Cell Transplant in Patients With Hematological Cancer

Completed·NNorthside Hospital, Inc.·Phase 2·NCT00787761·24 enrolled

Donor Stem Cell Transplant in Treating Older or Frail Patients With Hematologic Cancer

Completed·UUniversity of California, San Francisco·N/A·NCT00296023·25 enrolled

Pregnancy3 trials

Assessment of the Efficacy of Letrozole in the Treatment of Ectopic Pregnancy

Unknown status·TTehran University of Medical Sciences·Phase 1/2·NCT05918718·150 enrolled

Sequential Letrozole and Methotrexate Therapy Role in Treatment of Tubal Ectopic Pregnancy

Completed·ZZagazig University·N/A·NCT06426979·200 enrolled

Medical Treatment in Ectopic Tubal Pregnancy

Completed·NNishtar Medical University·N/A·NCT05208034·100 enrolled

Primary Biliary Cirrhosis2 trials

Phase III Randomized Study of Ursodiol With Vs Without Methotrexate for Primary Biliary Cirrhosis

Completed·NNational Center for Research Resources (NCRR)·Phase 3·NCT00004784·315 enrolled

Ursodiol-Methotrexate for Primary Biliary Cirrhosis

Completed·NNational Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)·Phase 3·NCT00006168

Arthritis2 trials

STep-up and Step-down Therapeutic Strategies in Childhood ARthritiS

Recruiting·IIstituto Giannina Gaslini·Phase 3·NCT03728478·260 enrolled

Multicenter Randomized Prospective Trial Comparing Methotrexate Alone or in Combination With Adalimumab in Early Arthritis

Unknown status·GGoupe d'Etudes et de Recherche Clinique En Rhumatologie·Phase 4·NCT00291915·80 enrolled

Advanced Head and Neck Cancer2 trials

Methotrexate Compared With Paclitaxel in Treating Patients With Advanced Head and Neck Cancer

Completed·EEastern Cooperative Oncology Group·Phase 3·NCT00003592·230 enrolled

Radiation Therapy With or Without Chemotherapy in Treating Patients With Advanced Head and Neck Cancer

Completed·CCancer Research UK·Phase 3·NCT00002476

Juvenile Idiopathic Arthritis2 trials

A Study to Evaluate the Pharmacokinetics, Efficacy and Safety of Intravenous Golimumab in Pediatric Participants With Active Polyarticular Course Juvenile Idiopathic Arthritis Despite Methotrexate Therapy

Completed· Johnson & Johnson logo

Johnson & Johnson·Phase 3·NCT02277444·130 enrolled

Juvenile Idiopathic Arthritis (JIA) Registry

Completed· AbbVie logo

AbbVie··NCT00783510·849 enrolled

Ankylosing Spondylitis2 trials

Methotrexate in Ankylosing Spondylitis (MTX in AS)

Unknown status·—·Phase 2·NCT00243750·20 enrolled

Effect of the Combination of Methotrexate and Adalimumab on Reduction of Immunization in Ankylosing Spondylitis (COMARIS)

Completed·UUniversity Hospital, Tours·Phase 4·NCT01895764·110 enrolled

Bladder Cancer2 trials

Perioperative Durvalumab With Neoadjuvant ddMVAC or Gemcitabine/Cisplatin in Patients With Muscle-invasive Bladder Cancer (NIAGARA-2)

Recruiting· AstraZeneca logo

AstraZeneca·Phase 3·NCT06960577·150 enrolled

Drug Screening Using IMD in Bladder Cancer

Unknown status·—·Phase 1·NCT06204614·18 enrolled

Bone Marrow Transplantation2 trials

Monoclonal Antibody Followed by Bone Marrow Transplantation in Treating Patients With Acute Myelogenous Leukemia in Remission or First Relapse

Completed·FFred Hutchinson Cancer Center·Phase 2·NCT00002554·30 enrolled

Phase II Study of Bone Marrow Transplantation Using Related Donors in Patients With Aplastic Anemia

Completed·NNational Center for Research Resources (NCRR)·Phase 2·NCT00004323·10 enrolled

Acute Leukemia2 trials

Comparing Post-Transplant Cyclophosphamide As GVHD Prophylaxis to Standard of Care for Acute Leukemia Patients

Recruiting·KKing Faisal Specialist Hospital & Research Center·Phase 3·NCT04314219·264 enrolled

Filgrastim-Treated Donor Peripheral Stem Cell Transplantation in Treating Patients With Acute Leukemia</p>

Completed·FFred Hutchinson Cancer Center·Phase 2·NCT00025545

Newly Diagnosed2 trials

PD-1 Inhibitor Combined With Rituximab, Methotrexate, and Orelabrutinib (PD-1i+RMO) for Newly Diagnosed PCNSL and SCNSL.

Recruiting·TThe First Affiliated Hospital with Nanjing Medical University·Phase 2·NCT07410520·50 enrolled

CHIP-AML22/Quizartinib: Quizartinib + Chemotherapy in Newly Diagnosed Pediatric FLT3-ITD+ and NPM1wt AML Patients

Recruiting·PPrincess Maxima Center for Pediatric Oncology·Phase 2·NCT06262438·60 enrolled

Acute Graft Versus Host Disease2 trials

To Compare the Efficacy of the Addition of Methotrexate (MTX) to Current Standard Acute Graft-versus-host Disease (GVHD) First-line Treatment With Corticosteroids

Unknown status·AAssistance Publique - Hôpitaux de Paris·Phase 3·NCT03371667·102 enrolled

Methotrexate and Glucocorticoids in Treating Patients With Newly Diagnosed Acute Graft-Versus-Host Disease After Donor Stem Cell Transplant

Completed·FFred Hutchinson Cancer Center·Phase 2·NCT00357084·53 enrolled

Pomalidomide1 trial

Sequential Treatment With RO-MTX After Pomalidomide, Orelabrutinib, Rituximab (POR) in Newly-diagnosed PCNSL

Recruiting·PPeking Union Medical College Hospital·Phase 2·NCT05390749·50 enrolled

Hematologic Malignancies1 trial

Tagraxofusp in Pediatric Patients With Relapsed or Refractory CD123 Expressing Hematologic Malignancies

Recruiting·TTherapeutic Advances in Childhood Leukemia Consortium·Phase 1·NCT05476770·54 enrolled

Drug1 trial

To Evaluate The Effect Of SAR153191 (REGN88) Added To Other RA Drugs In Patients With RA Who Are Not Responding To Or Intolerant Of Anti-TNF Therapy (SARIL-RA-TARGET)

Completed· Sanofi logo

Sanofi·Phase 3·NCT01709578·546 enrolled

Advanced Cancer1 trial

Two-Drug Combination Chemotherapy Compared With Four-Drug Combination Chemotherapy in Treating Patients With Advanced Cancer of the Urothelium

Completed·EEastern Cooperative Oncology Group·Phase 3·NCT00003376·330 enrolled

Hypophosphatasia1 trial

Mitigate Immune-Mediated Loss of Therapeutic Response to Asfotase Alfa (STRENSIQ®) for Hypophosphatasia

Withdrawn· AstraZeneca logo

AstraZeneca·Phase 4·NCT06015750

Vaccine Response1 trial

MTX Discontinuation and Vaccine Response

Completed·SSeoul National University Hospital·Phase 4·NCT02748785·277 enrolled

Neoadjuvant Chemotherapy1 trial

Neoadjuvant Chemotherapy With Methotrexate, Vinblastine, Adriamycin and Cisplatin (M-VAC) Plus Avastin in Patients With Urothelial Cancer

Completed·MM.D. Anderson Cancer Center·Phase 2·NCT00506155·60 enrolled

Pediatric ALL1 trial

ABT-751 With Chemotherapy for Relapsed Pediatric ALL

Terminated·TTherapeutic Advances in Childhood Leukemia Consortium·Phase 1/2·NCT00439296·9 enrolled

TACE1 trial

Abatacept Post-marketing Clinical Study in Japan

Completed· Bristol-Myers Squibb logo

Bristol-Myers Squibb·Phase 4·NCT01758198·405 enrolled

Adalimumab1 trial

ADalimumab in Persistent Early Oligoarthrits Study (ADEOS)

Completed·UUniversity of Leeds·Phase 2·NCT04154852·22 enrolled

Sickle Cell Disease1 trial

Abatacept for GVHD Prophylaxis After Hematopoietic Stem Cell Transplantation for Pediatric Sickle Cell Disease

Completed·MMonica Bhatia·Phase 1·NCT02867800·24 enrolled

Hematologic Disorder1 trial

Nonmyeloablative Allo SCT for the Treatment of Hematologic Disorders

Completed·—·Phase 2·NCT00636909·25 enrolled

Erythema1 trial

Methotrexate and Prednisolone Study in Erythema Nodosum Leprosum

Active, not recruiting·LLondon School of Hygiene and Tropical Medicine·N/A·NCT03775460·550 enrolled

Thalassemia1 trial

Hematopoietic Stem Cell Transplantation for Patients With Thalassemia Major: A Multicenter, Prospective Clinical Study

Completed·FFirst Affiliated Hospital of Guangxi Medical University·Phase 4·NCT04009525·823 enrolled

Immunotherapy1 trial

Pilot Study of MGd + High-dose MTX-Based Chemoimmunotherapy + RT for Newly Dx PCNSL

Withdrawn·NNorthwestern University·Phase 1·NCT00734773

Osteosarcoma1 trial

A Retrospective Non-intervention Study to Characterize FOlate Rescue Treatment in Osteosarcoma Patients Treated With HDMTX

Completed·IIsofol Medical AB··NCT02383901·116 enrolled

Acute Leukemia of Ambiguous Lineage1 trial

Efficacy of Acute Lymphoblastic Leukemia-Based Therapy in Treating Patients With Acute Leukemia of Ambiguous Lineage

Recruiting·IInstitute of Hematology & Blood Diseases Hospital, China·Phase 2·NCT04440267·50 enrolled

Interstitial Lung Disease1 trial

Effects of Tofacitinib vs Methotrexate on Rheumatoid Arthritis Interstitial Lung Disease

Terminated·VVastra Gotaland Region·Phase 4·NCT04311567·3 enrolled

Asthma1 trial

Low-dose Methotrexate for Change in Global Initiative for Asthma Step 5 Medications in Chronic Severe Asthma

Unknown status·UUniversita degli Studi di Catania·Phase 3·NCT02124226·102 enrolled

Vasculitis1 trial

The Effect of Some Drugs Used in Treatment of Vasculitis on the Complement System in Children

Unknown status·—·Phase 3·NCT03692416·70 enrolled

Mucous Membrane Pemphigoid1 trial

Baricitinib for the Treatment of Ocular Mucous Membrane Pemphigoid

Terminated·WWashington University School of Medicine·Phase 2·NCT05263505·2 enrolled

Vitiligo1 trial

Combination of Methotrexate and Phototherapy Versus Phototherapy in Adults With Progressive Vitiligo

Completed·UUniversity Hospital, Bordeaux·Phase 2·NCT04237103·32 enrolled

Atopic Dermatitis1 trial

Study of Methotrexate Efficacy Versus Cyclosporine in Moderate to Severe Atopic Dermatitis Patients

Completed·HHospices Civils de Lyon·Phase 3·NCT00809172·100 enrolled

Intermediate Uveitis1 trial

Randomized, Controlled Trial to Test the Efficacy of Interferon Beta in the Treatment of Intermediate Uveitis

Completed·HHeidelberg University·Phase 3·NCT00344253·19 enrolled

Phase II1 trial

ZR-MTX for PIOL Phase II Trial

Not yet recruiting·PPeking Union Medical College Hospital·Phase 2·NCT06973811·47 enrolled

Trial1 trial

PRINTO (the Paediatric Rheumatology International Trials Organisation)

Unknown status·IInstitute of Child Health··NCT00415935

Chemotherapy1 trial

Doxorubicin With Cisplatin, High-Dose Methotrexate, and Additional Risk-Adapted Outpatient Chemotherapy

Terminated·MM.D. Anderson Cancer Center·N/A·NCT00673179·7 enrolled

Cervical Cancer1 trial

Radiation Therapy With or Without Chemotherapy After Surgery in Treating Patients With Stage IB or Stage IIA Cervical Cancer

Completed·EEuropean Organisation for Research and Treatment of Cancer - EORTC·Phase 3·NCT00003209·700 enrolled

Osteoarthritis1 trial

Methotrexate in the Treatment of Advanced Knee Osteoarthritis With Effusion-synovitis

Completed·ZZhujiang Hospital·N/A·NCT03815448·215 enrolled

Imetelstat1 trial

A Study to Find the Highest Dose of Imetelstat in Combination With Fludarabine and Cytarabine for Patients With AML, MDS or JMML That Has Come Back or Does Not Respond to Therapy

Recruiting·CChildren's Oncology Group·Phase 1·NCT06247787·36 enrolled

Chidamide1 trial

Precision Diagnosis Directing HDACi Chidamide Target Therapy for Adult T-LBL/ALL

Unknown status·NNanfang Hospital, Southern Medical University·Phase 2/3·NCT03564704·80 enrolled

Medulloblastoma1 trial

Molecular and Clinical Risk-Directed Therapy for Infants and Young Children With Newly Diagnosed Medulloblastoma

Recruiting·SSt. Jude Children's Research Hospital·Phase 2·NCT05535166·130 enrolled

Primitive Neuroectodermal Tumor1 trial

Radiation Therapy and Combination Chemotherapy in Treating Young Patients With Medulloblastoma, Supratentorial Primitive Neuroectodermal Tumor, or Ependymoma

Completed·UUniversitätsklinikum Hamburg-Eppendorf·N/A·NCT00303810·567 enrolled

Urothelial Cancer1 trial

Gemcitabine Hydrochloride and Cisplatin or High-Dose Methotrexate, Vinblastine, Doxorubicin Hydrochloride, and Cisplatin in Treating Patients With Urothelial Cancer

Withdrawn·UUniversity of Southern California·Phase 2·NCT01639521

Histiocytosis1 trial

Hybrid Immunotherapy for Hemophagocytic LymphoHistiocytosis

Completed·—·Phase 2·NCT01104025·31 enrolled

Myelodysplastic Syndrome1 trial

Alloreactive NK Cells for Allogeneic Stem Cell Transplantation for Acute Myeloid Leukemia (AML) and Myelodysplastic Syndrome (MDS)

Completed·MM.D. Anderson Cancer Center·Phase 1·NCT00402558·15 enrolled

Chronic Myelogenous Leukemia1 trial

Combination Chemotherapy Followed by Peripheral Stem Cell Transplantation in Treating Patients With Chronic Myelogenous Leukemia or Myelodysplastic Syndrome

Completed·FFred Hutchinson Cancer Center·Phase 2·NCT00027924

Urinary Tract Cancer1 trial

Chemotherapy Before Surgery in Treating Patients With High Grade Upper Urinary Tract Cancer

Completed·EECOG-ACRIN Cancer Research Group·Phase 2·NCT02412670·36 enrolled

Chronic Lymphocytic Leukemia1 trial

Fludarabine and Cyclophosphamide in Treating Patients Who Are Undergoing Donor Stem Cell Transplant for Chronic Lymphocytic Leukemia or Waldenstrom's Macroglobulinemia

Completed·GGerman CLL Study Group·Phase 1/2·NCT00281983·100 enrolled

Ulcerative Colitis1 trial

Methotrexate in Induction and Maintenance of Steroid Free Remission in Ulcerative Colitis

Completed·UUniversity of North Carolina, Chapel Hill·Phase 2·NCT01393405·179 enrolled

Myeloproliferative Disorder1 trial

Combination Chemotherapy Plus Bone Marrow or Peripheral Stem Cell Transplantation in Treating Patients With Myeloproliferative Disorders

Completed·FFred Hutchinson Cancer Center·Phase 2·NCT00002792·20 enrolled

Myeloid1 trial

Myeloid-Derived Suppressor Cells and Checkpoint Immune Regulators' Expression in Allogeneic SCT Using FluBuATG

Completed·—·Phase 1·NCT02916979·20 enrolled

Uncontrolled Gout1 trial

Study of KRYSTEXXA® (Pegloticase) Plus Methotrexate in Participants With Uncontrolled Gout

Completed· Amgen logo

Amgen·Phase 4·NCT03994731·152 enrolled

Graft Vs Host Disease1 trial

Vorinostat Plus Tacrolimus & Methotrexate to Prevent Graft vs Host Disease Following Unrelated Stem Cell Transplant

Completed·UUniversity of Michigan Rogel Cancer Center·Phase 2·NCT01790568·26 enrolled

Stem Cell Transplantation1 trial

Zevalin-Containing Nonmyeloablative Conditioning for Stem Cell Transplantation (SCT)

Completed·MM.D. Anderson Cancer Center·Phase 2·NCT01490723·20 enrolled

Fasciitis1 trial

Treatment With High Dose Methotrexate in Patients With Eosinophilic Fasciitis

Completed·RRadboud University Medical Center·N/A·NCT00441961·6 enrolled

T-cell non-Hodgkin lymphoma1 trial

Combination Chemotherapy and Denileukin Diftitox in Treating Patients With Newly Diagnosed T-Cell Non-Hodgkin Lymphoma

Withdrawn·UUniversity of Miami·N/A·NCT00513188

Acute Promyelocytic Leukemia1 trial

S0521, Combination Chemotherapy With or Without Gemtuzumab Followed By Tretinoin, Mercaptopurine, and Methotrexate or Observation in Treating Patients With Acute Promyelocytic Leukemia

Completed·SSWOG Cancer Research Network·Phase 3·NCT00492856·105 enrolled

Lichen Planopilaris1 trial

The Effectiveness of Hydroxychloroquine Versus Methotrexate in the Treatment of Lichen Planopilaris in Routine Clinical Care: a Patient Preference Trial

Recruiting·EErasmus Medical Center··NCT06512753·56 enrolled

Acute Myeloid Leukemia1 trial

Fludarabine and Busulfan Followed by Allogeneic Stem Cell Transplant in Treating Older Patients With Acute Myeloid Leukemia in First Complete Remission

Completed·AAlliance for Clinical Trials in Oncology·Phase 2·NCT00070135·121 enrolled

Refractory Solid Tumors1 trial

Donor Stem Cell Transplant in Treating Young Patients With Relapsed or Refractory Solid Tumors

Completed·MMilton S. Hershey Medical Center·Phase 1·NCT00112645·10 enrolled

Anemia1 trial

Cyclophosphamide in Treating Patients Who Are Undergoing a Donor Bone Marrow Transplant for Fanconi's Anemia

Completed·FFred Hutchinson Cancer Center·Phase 1·NCT00317876·25 enrolled

Anaplastic Large Cell Lymphoma1 trial

Combination Chemotherapy in Treating Children With Anaplastic Large Cell Lymphoma (ALCL 99)

Completed·GGustave Roussy, Cancer Campus, Grand Paris·Phase 3·NCT00006455·885 enrolled

Severe Aplastic Anemia1 trial

Cyclophosphamide and Anti-thymocyte Globulin Followed By Methotrexate and Cyclosporine in Preventing Chronic Graft-Versus-Host Disease in Patients With Severe Aplastic Anemia Undergoing Donor Bone Marrow Transplant

Completed·FFred Hutchinson Cancer Center·Phase 2·NCT00343785·21 enrolled

Peripheral Blood Stem Cell Transplantation1 trial

Comparing ATG or Post-Transplant Cyclophosphamide to Calcineurin Inhibitor-Methotrexate as GVHD Prophylaxis After Myeloablative Unrelated Donor Peripheral Blood Stem Cell Transplantation

Withdrawn·FFred Hutchinson Cancer Center·Phase 2·NCT03602898

Ovarian Cancer1 trial

Methotrexate Plus Dipyridamole in Treating Patients With Advanced Ovarian Cancer

Unknown status·OOttawa Regional Cancer Centre·Phase 2·NCT00002487

Multiple Sclerosis1 trial

Combination Therapy With Avonex and BiMonthly High Dose Intravenous Methotrexate in Multiple Sclerosis

Completed·MMidAmerica Neuroscience Research Foundation at Rowe Neurology Institute·Phase 4·NCT00037102·16 enrolled

Adult Acute Lymphoblastic Leukemia1 trial

Rituximab Plus Chemotherapy for CD20+ Adult Acute Lymphoblastic Leukemia

Completed·RRuijin Hospital·Phase 4·NCT01358253·100 enrolled

Regulatory

FDA Approval Timeline[5]

Jan 1, 1982

METHOTREXATE SODIUM

NDA NDA008085

Mar 31, 1982

METHOTREXATE LPF

NDA NDA011719

Jul 10, 2014

RASUVO

NDA NDA205776

Nov 7, 2014

OTREXUP

NDA NDA204824

Apr 25, 2017

XATMEP

NDA NDA208400

Nov 27, 2019

REDITREX

NDA NDA210737

Aug 24, 2020

METHOTREXATE

NDA NDA214121

Nov 29, 2022

JYLAMVO

NDA NDA212479

Sources

References

[1]
ClinicalTrials.gov — 1186 trial records for Methotrexate. U.S. National Library of Medicine, National Institutes of Health.
[2]
MedlinePlus Drug Information — Trexall drug information. U.S. National Library of Medicine, National Institutes of Health.
[3]
ChEMBL — Methotrexate compound record. European Bioinformatics Institute (EMBL-EBI).
[4]
Open Targets Platform — Drug–disease associations for Methotrexate. EMBL-EBI & Wellcome Sanger Institute.
[5]
OpenFDA — FDA approval records (NDA NDA212479). U.S. Food & Drug Administration.
[6]
FDA Orange Book — Patent and exclusivity data for Trexall. U.S. Food & Drug Administration.
[7]
SEC EDGAR — Alnylam Pharmaceuticals company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Mechanism of Action: Dihydrofolate Reductase Inhibitor[3]
Modality: Small molecule[3]
Highest Phase: Approved[1]
Company: Alnylam Pharmaceuticals

Patent Landscape[6]

Patent Cliff

Oct 4, 2026

Earliest patent expiration — generic entry possible after this date

Patent #Expires

9629959Jan 24, 2026

11446441Jan 24, 2026

8562564Jan 24, 2026

9533102Jan 24, 2026

8021335Oct 4, 2026

21 more patents

10709844Mar 10, 2029

9867949Mar 10, 2029

11684723Mar 10, 2029

8664231Jun 1, 2029

8480631Mar 19, 2030

8579865Mar 19, 2030

8945063Mar 19, 2030

9421333Mar 19, 2030

11497753Mar 19, 2030

12357642Mar 19, 2030

8814834May 27, 2031

11969503Jan 2, 2033

11116724Jan 2, 2033

10610485Jan 2, 2033

12396947Jan 2, 2033

9855215Jan 2, 2033

9259427Jan 2, 2033

10231927Jan 2, 2033

11771701Oct 29, 2034

12605385Oct 25, 2035

11129833Oct 28, 2035