Azactam
(Aztreonam)ApprovedSmall molecule
This is an antibiotic injection used to treat bacterial infections in various parts of the body, including the lungs, urinary tract, blood, skin, and abdomen. It can also be used to prevent infections before or after surgery. The medication works by killing bacteria that cause these infections.[2] Azactam is currently approved and in use across 2 indications[4].[1]
Azactam is one of 62 small molecule programs targeting Liver. It is currently in Approved.
2
Indications
14
Total Trials
1
Active Trials
61
Competitors
3
FDA Applications
NDA/BLA/ANDA regulatory filings
Pipeline
Status by Indication[4][1]
Competition
Competitive Landscape
107 competitors in Cystic Fibrosis
#DrugCompanyPhaseTrials
1Ibsrela
AArdelyx
Phase 3
Azactam
KKaruna Therapeutics, Inc., a Bristol Myers Squibb company
Approved
Lamprene
NovartisPhase 2
HSK31858
Haisco Pharmaceutical Group Co., Ltd.Phase 3
Sirturo
WWim Janssens
Phase 2
ELX/TEZ/IVA
Vertex PharmaceuticalsPhase 3
Trikafta
NNottingham University Hospitals NHS Trust
Phase 3
VNZ/TEZ/D-IVA
Vertex PharmaceuticalsPhase 3
VX-121/TEZ/D-IVA
Vertex PharmaceuticalsPhase 3
Hyperpolarized Xenon-129
TThunder Bay Regional Health Research Institute
Phase 3
Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.
Timeline
Expected Milestones
Clinical
Trials by Indication[1]
Cystic Fibrosis2 trials
Infections2 trials
Skin Infection2 trials
6 more indications
Efficacy and Safety1 trial
Peritonitis1 trial
Adolescent1 trial
Liver1 trial
Targeted Versus Standard Peri-operative Antibiotic Prophylaxis in Patients Colonized With Carbapenemase-producing Enterobacterales Undergoing Liver Transplantation: a Stepped Wedge Cluster Randomization Trial
Not yet recruiting·IIRCCS Azienda Ospedaliero-Universitaria di Bologna·Phase 3·NCT07759453·168 enrolled
Regulatory
FDA Approval Timeline[5]
Dec 31, 1986
AZACTAM
NDA NDA050580
May 24, 1989
AZACTAM IN PLASTIC CONTAINER
NDA NDA050632
Feb 22, 2010
CAYSTON
NDA NDA050814
Sources
References
- [1]
- [2]MedlinePlus Drug Information — Azactam drug information. U.S. National Library of Medicine, National Institutes of Health.
- [3]
- [4]Open Targets Platform — Drug–disease associations for Aztreonam. EMBL-EBI & Wellcome Sanger Institute.
- [5]
- [6]
Details