Cannabis oil

Phase 3Small molecule

TTO Pharmaceuticals

Cannabis oil is one of 127 small molecule programs targeting Restless Legs Syndrome. It is currently in Phase 3.

Indications

Total Trials

Active Trials

126

Competitors

Pipeline

Status by Indication[3][1]

Indication

Restless Legs SyndromeActive, not recruiting

Hidradenitis SuppurativaActive, not recruiting

FibromyalgiaActive, not recruiting

Restless Legs SyndromePreclinical

Active, not recruiting

Hidradenitis SuppurativaPhase 2

Active, not recruiting

FibromyalgiaPhase 2

Active, not recruiting

Competition

Competitive Landscape

152 competitors in Fibromyalgia

#DrugCompanyPhaseTrials

Xyrem

Jazz Pharmaceuticals

Phase 3

1 2

Epidiolex

Jazz Pharmaceuticals

Phase 3

1 3

Namenda

AbbVie

Phase 3

1 4

Neurontin

VViatris Specialty LLC

Phase 3

3 5

Ultram

WWim Janssens

Phase 3

1 6

Prozac

VVitae Pharmaceuticals Inc., an Allergan affiliate

Phase 3

1 7

DS-5565

Daiichi Sankyo

Phase 3

4 8

Feosol

AAuerbach Hematology Oncology Associates P C

Genotropin

Saizen

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q2 2027

Phase 2Recruiting

Fibromyalgia

NCT06946940

Q3 2027

Phase 3Not yet recruiting

Pruritus

NCT06435299

Clinical

Trials by Indication[1]

Cannabis2 trials

Safety and Pharmacokinetics of Extrato de Cannabis Sativa GreenCare

Recruiting·GGreenCare Pharma·Phase 1·NCT06807762·72 enrolled

Pharmacokinetics and Pharmacological Effects of a Standardized Cannabis Preparation

Completed·GGermans Trias i Pujol Hospital·Phase 1·NCT04841993·43 enrolled

Pain1 trial

Cannabinoids Effects on the Pain Modulation System

Unknown status·TTel-Aviv Sourasky Medical Center·N/A·NCT02560545·40 enrolled

Dialysis Patients1 trial

Impact of Cannabis Oil on Nutrition in Hemodialysis Patients Study (ICON-HP Study)

Withdrawn·—·Phase 3·NCT03664141

Treatment1 trial

Treatment With Cannabis Oil Containing CBD, THC, CBDV or CBG vs. Placebo of Persons With ADHD

Terminated·BBrlev Agricultural Crops Ltd·Phase 2·NCT05219370·8 enrolled

Parkinson's Disease1 trial

Cannabis Oil for Pain in Parkinson's Disease

Unknown status·UUniversity Health Network, Toronto·Phase 2·NCT03639064·15 enrolled

5 more indications

Hidradenitis Suppurativa1 trial

Study to Investigate the Efficacy and Safety of Cannabis Oil for the Treatment of Subjects With Hidradenitis Suppurativa

Withdrawn·TTO Pharmaceuticals·Phase 2·NCT03929835

Restless Legs Syndrome1 trial

Using Cannabis to Treat Restless Legs Syndrome

Recruiting·SSunnybrook Health Sciences Centre·N/A·NCT06863740·30 enrolled

Pruritus1 trial

Efficacy and Tolerance of Cannabidiol in Patients with Severe Pruritus: a Multicenter, Double-blind, Randomized, Placebo-controlled Study

Not yet recruiting·UUniversity Hospital, Brest·Phase 3·NCT06435299·218 enrolled

Children1 trial

The Effects of Medical Cannabis in Children With Autistic Spectrum Disorder

Completed·—·Phase 3·NCT05212493·128 enrolled

Fibromyalgia1 trial

Biosignature of the Response to Treatment With Cannabis Oil in Individuals With Fibromyalgia

Recruiting·RRambam Health Care Campus·Phase 2·NCT06946940·150 enrolled

Sources

References

[1]
ClinicalTrials.gov — 11 trial records for Cannabis oil. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — Cannabis oil compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for Cannabis oil. EMBL-EBI & Wellcome Sanger Institute.
[4]
SEC EDGAR — TO Pharmaceuticals company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[2]
Highest Phase: Phase 3[1]
Company: TTO Pharmaceuticals

Cannabis oil

Status by Indication[3][1]

Competitive Landscape

Expected Milestones

Q2 2027

Q3 2027

Trials by Indication[1]

Cannabis2 trials

Pain1 trial

Dialysis Patients1 trial

Treatment1 trial

Parkinson's Disease1 trial

Hidradenitis Suppurativa1 trial

Restless Legs Syndrome1 trial

Pruritus1 trial

Children1 trial

Fibromyalgia1 trial

References

Drug Info

Quick Facts

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