Paracetamol

Phase 3Small molecule

GSK

Paracetamol is one of 316 small molecule programs targeting Analgesic Efficacy. It is currently in Phase 3.

Indications

328

Total Trials

Active Trials

315

Competitors

Pipeline

Status by Indication[3][1]

Indication

Analgesic EfficacyCompleted

Retinopathy of PrematurityActive, not recruiting

Femur FractureActive, not recruiting

Rib FractureActive, not recruiting

Insulin SecretionActive, not recruiting

AbortionActive, not recruiting

DysmenorrheaActive, not recruiting

Oxidative StressActive, not recruiting

DiverticulitisActive, not recruiting

HysterectomyActive, not recruiting

Analgesic EfficacyPhase 3

Completed

Retinopathy of PrematurityPreclinical

Active, not recruiting

Femur FracturePreclinical

Active, not recruiting

Rib FracturePreclinical

Active, not recruiting

Insulin SecretionPreclinical

Active, not recruiting

AbortionPreclinical

Active, not recruiting

DysmenorrheaPreclinical

Active, not recruiting

Oxidative StressPreclinical

Active, not recruiting

DiverticulitisPreclinical

Active, not recruiting

HysterectomyPreclinical

Active, not recruiting

Showing 10 of 23 indications

Competition

Competitive Landscape

744 competitors in Breast Cancer

#DrugCompanyPhaseTrials

Paracetamol

GSK

Phase 3

1 2

Adenocard

Astellas

Preclinical

2 3

Lexiscan

Astellas

Preclinical

1 4

Methylthioninium Chloride

PProvepharm SAS

Preclinical

3 5

Duragesic

CCephalon

Preclinical

1 6

Sporanox

SSebela Pharmaceuticals Development LLC

Preclinical

1 7

Vfend

PPrism Pharmaceuticals

Preclinical

—8

Neoadjuvant Treatment

SShanghai Zhongshan Hospital

Preclinical

1 9

Tianeptine

Pfizer

Preclinical

1 10

Diuretic

RReprieve Cardiovascular, Inc

Preclinical

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q2 2027

Phase 1/2Active, not recruiting

Meningococcal Disease

NCT06647407

Clinical

Trials by Indication[1]

Patent ductus arteriosus8 trials

Platelet Transfusion for Treatment of Patent Ductus Arteriosus in Thrombocytopenic Preterm Neonates

Completed·PPost Graduate Institute of Medical Education and Research, Chandigarh·Phase 3·NCT03022253·44 enrolled

Assessment of Therapeutic Effect of Rectal Vs. Intravenous Paracetamol in The Treatment of Patent Ductus Arteriosus (PDA) in Neonates

Unknown status·SSoha mahmoud Hussien mahdy·Phase 1/2·NCT06256211·100 enrolled

Paracetamol and Patent Ductus Arteriosus (PDA)

Unknown status·SShaare Zedek Medical Center·Phase 2·NCT01291654·80 enrolled

Show 5 more trials

Comparision Between Paracetamol and Ibuprofen in Closure of Patent Ductus Arteriosus

Unknown status·—·Phase 2·NCT06152796·56 enrolled

Adding Paracetamol to Ibuprofen for Treatment of Patent Ductus Arteriosus in Preterm Infants

Completed·RRambam Health Care Campus·Phase 2/3·NCT02002741·24 enrolled

Oral Paracetamol Versus Oral Ibuprofen in Management of Patent Ductus Arteriosus in Preterm Infants: A Randomised Controlled Trial

Completed·ZZekai Tahir Burak Women's Health Research and Education Hospital·Phase 4·NCT01536158·80 enrolled

Serum Level Measurement of Oral Paracetamol and Oral Ibuprofen for Patent Ductus Arteriosus Treatment in Preterm Infants

Unknown status·ZZekai Tahir Burak Women's Health Research and Education Hospital·Phase 4·NCT01544972·80 enrolled

Paracetamol Versus Ibuprofen in Premature Infants With Hemodynamically Significant Patent Ductus Arteriosus

Completed·MMáximo Vento Torres·Phase 3·NCT04037514·133 enrolled

Intravenous6 trials

Pharmacokinetics, -Dynamics and Safety of Intravenous Paracetamol in Neonates

Completed·UUniversitaire Ziekenhuizen KU Leuven·Phase 2/3·NCT00969176·60 enrolled

Comparison of the Efficacy of Intravenous Dexketoprofen and Paracetamol in the Treatment of Sore Throat

Completed·PPamukkale University·Phase 4·NCT03768882·200 enrolled

Intravenous Paracetamol Versus Intramuscular Tramadol in Shortening the Duration of Labour.

Completed·FFederal Teaching Hospital Abakaliki·N/A·NCT07394491·189 enrolled

Show 3 more trials

Intravenous Paracetamol or Morphine for the Treatment of Acute Flank Pain

Completed·PPamukkale University·Phase 4·NCT01318187·73 enrolled

Efficacy of Intravenous (IV) Paracetamol for Treatment of Acute Pain

Completed·TTehran University of Medical Sciences·Phase 4·NCT01465984·60 enrolled

Disposition of Intravenous Paracetamol in Young Women

Completed·UUniversitaire Ziekenhuizen KU Leuven··NCT02590900·69 enrolled

Treatment5 trials

Treatment Of Fever In The Emergency Department

Completed·FFondazione Policlinico Universitario Agostino Gemelli IRCCS··NCT05814302·324 enrolled

Prophylactic Antipyretic Treatment in Children Receiving Pneumococcal Conjugate and Standard Infant Vaccines

Completed· GSK logo

GSK·Phase 3·NCT00370318·400 enrolled

Operative Treatment of Unstable Thoracic Cage Injuries and Chest Wall Deformity in Trauma

Completed·SSahlgrenska University Hospital·N/A·NCT02132416·92 enrolled

Show 2 more trials

Early Treatment Versus Expectant Management of PDA in Preterm Infants

Completed·LLviv National Medical University·N/A·NCT03860428·208 enrolled

Prophylactic Antipyretic Treatment in Children Receiving Booster Dose of Pneumococcal Conjugate Vaccine GSK1024850A

Completed· GSK logo

GSK·Phase 3·NCT00496015·750 enrolled

Postoperative Analgesia5 trials

Controlled-Release Oxycodone For Postoperative Analgesia After Video-Assisted Thoracic Surgery

Terminated·UUniversity of Parma·Phase 4·NCT00681174·22 enrolled

Postoperative Analgesia After Minithoracotomy

Completed·MMedical University of Lublin·Phase 4·NCT03415555·19 enrolled

Non-opioid Analgesic Combination With Morphine for Postoperative Analgesia.

Terminated·RRennes University Hospital·Phase 4·NCT01882530·223 enrolled

Show 2 more trials

Perioperative Electroacupuncture on Postoperative Analgesia in Prostatectomy

Completed·GG.Gennimatas General Hospital·Phase 4·NCT01526525·70 enrolled

Intravenous Paracetamol Compared Dexketoprofen for Postoperative Analgesia After Septoplasty

Unknown status·—·Phase 3·NCT02602197·2 enrolled

Post Operative Pain4 trials

Intravenous Paracetamol for Postoperative Pain

Completed·LLithuanian University of Health Sciences·Phase 4·NCT02248493·54 enrolled

Codeine Plus Paracetamol Versus Placebo for PRK Post-operative Pain

Completed·UUniversity of Sao Paulo General Hospital·Phase 3·NCT02625753·40 enrolled

Effectiveness of Pre-emptive Analgesics on Post-Operative Pain After Stainless Steel Crown Placement On Primary Molars

Completed·—·Phase 4·NCT05602064·66 enrolled

Show 1 more trial

The Effect of Dexamethasone in Combination With Paracetamol and Ibuprofen on Postoperative Pain After Spine Surgery

Completed·RRigshospitalet, Denmark·Phase 4·NCT01953978·160 enrolled

130 more indications

Headache4 trials

Clinical Study to Evaluate Efficacy of New Paracetamol Formulation Compared to Ibuprofen in Headache

Terminated· GSK logo

GSK·Phase 3·NCT01842633·365 enrolled

Paracetamol With Caffeine to Treat Episodic Tension Type Headache

Terminated· GSK logo

GSK·Phase 2/3·NCT01755702·66 enrolled

Intravenous Dexketoprofen and Paracetamol in the Treatment of Headache Caused by Acute Migraine Attack

Completed·PPamukkale University·Phase 4·NCT01730326·200 enrolled

Show 1 more trial

Intravenous Paracetamol, Dexketoprofen and Ibuprofen in the Treatment of Acute Migraine Attack Headache

Unknown status·PPamukkale University·Phase 4·NCT04372264·210 enrolled

Renal Colic3 trials

Comparison of the Analgesic Efficacy of Dexketoprofen Trometamol, Meperidine, and Paracetamol in Renal Colic

Completed·IIsmail Tekin·Phase 4·NCT06558916·90 enrolled

Oral NSAI Versus Paracetamol or Placebo as a Second Line Treatment for Renal Colics

Completed·UUniversity of Monastir·Phase 3·NCT02304783·1,400 enrolled

Parecoxib vs Paracetamol in the Treatment of Acute Renal Colic

Completed·MMansoura University·Phase 4·NCT03704623·200 enrolled

Interaction3 trials

The Median Effective Dose (ED50) of Paracetamol and Morphine : A Study of Interaction Study

Completed·PProcare Riaya Hospital·N/A·NCT01366313·90 enrolled

Drug Interaction Between Paracetamol and Warfarin

Completed·HHopital Lariboisière·Phase 4·NCT01104337·45 enrolled

Clinical Confirmation of a Pharmacodynamic Interaction Between Tropisetron and Paracetamol

Completed·UUniversity Hospital, Clermont-Ferrand·Phase 4·NCT00487110·40 enrolled

AIN3 trials

The Effect of Paracetamol on Brain Temperature

Completed·FFondation Ophtalmologique Adolphe de Rothschild·Phase 4·NCT03648021·100 enrolled

Validation of a Physiological Based Pharmacokinetic Model by the Study of Paracetamol Distribution in the Brain Compartments in Brain Injured Patients

Completed·PPoitiers University Hospital·Phase 1·NCT03223506·17 enrolled

Measuring Blood Flow in the Brain After Epileptic Activity

Completed·RRijnstate Hospital·Phase 2·NCT04028596·34 enrolled

Ibuprofen3 trials

Population Pharmacokinetics and Dosage Individualization of Paracetamol and Ibuprofen in Children With PDA

Unknown status·SShandong University··NCT04397913·500 enrolled

Ibuprofen and Paracetamol Pharmacokinetic Study

Completed·RReckitt Benckiser Healthcare (UK) Limited·Phase 1·NCT02452450·43 enrolled

Paracetamol vs Ibuprofen for PDA Closure in Preterm Infants.

Suspended·UUniversity of Padova·Phase 2/3·NCT02056223·120 enrolled

Cesarean Section3 trials

Regional Analgesia After Cesarean Section

Completed·MMedical University of Lublin·Phase 4·NCT03244540·105 enrolled

To Study and Evaluate the Effectiveness of Treatment by Percutaneous Electrical NeuroStimulation (PENS) for Post-operative Pain in Cesarean Section Patients Using Primary Relief v 2.0

Unknown status·DDyAnsys, Inc.·N/A·NCT03829774·22 enrolled

Comparison of Two Pain-treatment Techniques After Cesarean Section

Completed·MMichał Borys·Phase 4·NCT02804126·232 enrolled

Influenza3 trials

The Benefit and Harm of Fever Suppression by Antipyretics in Influenza

Completed·TThe University of Hong Kong·Phase 4·NCT01891084·300 enrolled

A Comparison of Solid and Soluble Forms of Cold and Influenza Remedies

Completed· GSK logo

GSK·Phase 4·NCT01332578·25 enrolled

Oseltamivir Versus Paracetamol for Influenza-like Illness During the Influenza Season

Unknown status·RRambam Health Care Campus·Phase 4·NCT03754686·436 enrolled

Low back pain3 trials

Magnesium Oral Supplementation for Acute Non-specific Low Back Pain

Completed·IIstanbul University·N/A·NCT04626063·240 enrolled

IV Paracetamol, Dexketoprofen or Morphine for the Treatment of Low Back Pain

Completed·PPamukkale University·Phase 4·NCT01422291·120 enrolled

Comparison of Intravenous Ibuprofen and Paracetamol in Patients With Low Back Pain Presented to the Emergency Department

Unknown status·PPamukkale University·Phase 4·NCT02836509·200 enrolled

Cancer Pain3 trials

Paracetamol Versus Placebo in Conjunction With Strong Opioids for Cancer Pain

Terminated·UUniversity of Edinburgh·N/A·NCT02706769·34 enrolled

Paracetamol in Addition to WHO Step III Opioids in Chronic Cancer Pain Control

Recruiting·IInsel Gruppe AG, University Hospital Bern·Phase 4·NCT05088876·140 enrolled

Paracetamol for Cancer Pain

Unknown status·—·Phase 4·NCT01313247·50 enrolled

Hysterectomy2 trials

Elective Total Abdominal Hysterectomy With Preoperative Analgesia Intravenous Paracetamol Versus Placebo

Completed·QQueen Savang Vadhana Memorial Hospital, Thailand·N/A·NCT07368790·40 enrolled

Efficacy of Intravenous Paracetamol and Ibuprofen on Postoperative Pain and Morphine Consumption in Hysterectomy

Completed·IInonu University·N/A·NCT04691856·66 enrolled

Breast Surgery2 trials

ESP in Breast Surgery Due to Cancer

Completed·MMedical University of Lublin·Phase 4·NCT04726878·75 enrolled

Intercostal Nerves Block in the Midaxillary Line Versus Paravertebral Block for no Reconstructive Breast Surgery

Unknown status·PPaula Diéguez García·Phase 4·NCT02018601·120 enrolled

Musculoskeletal Pain2 trials

Comparison of Efficacy of Intravenous Paracetamol and Dexketoprofen for Acute Traumatic Musculoskeletal Pain

Completed·PPamukkale University·Phase 4·NCT03428503·200 enrolled

Comparison of Efficacy of Intravenous Paracetamol and Dexketoprofen for Acute Nontraumatic Musculoskeletal Pain

Completed·PPamukkale University·Phase 4·NCT03122314·200 enrolled

Analgesia2 trials

Efficacy of Paracetamol in Addition to Morphine to Improve Analgesia in the Emergency Department

Completed·BBruno Minotti·Phase 4·NCT03843281·222 enrolled

Paracetamol for Intrapartum Analgesia

Unknown status·—·Phase 2·NCT02578251·104 enrolled

Labor Analgesia2 trials

Epidural Tap in Labor Analgesia FOR LABOR ANALGESIA

Completed·MMedipol University·N/A·NCT05499234·70 enrolled

A Randomized Control Trial on Intravenous Paracetamol Versus Intramuscular Tramadol as Intra Partum Labor Analgesia

Completed·DDarlington-Peter Chibuzor Ugoji·Phase 2·NCT06371144·194 enrolled

Ketorolac2 trials

Adjuncts to IVRA, a Comparison Between Ketorolac and Paracetamol

Completed·—·Phase 3·NCT03485625·60 enrolled

Paracetamol Compared With Ketorolac for Post-operative Analgetic

Completed·IIndonesia University·Phase 4·NCT05523102·85 enrolled

Respiratory tract infection2 trials

Comparison of the Efficacy of Intravenous Paracetamol and Ibuprofen in the Treatment of Fever Due to Upper Respiratory Tract Infection

Completed·PPamukkale University·Phase 4·NCT03918135·200 enrolled

Placebo and Active Controlled Study to Compare the Antipyretic Efficacy of Aspirin® in Patients With Acute Febrile Upper Respiratory Tract Infections Suspected to be of Viral Origin

Completed· Bayer logo

Bayer·Phase 4·NCT01464944·392 enrolled

Analgesic2 trials

The Central Analgesic Effects of Paracetamol on Serotonergic Pathways

Completed·UUniversity Hospital, Basel, Switzerland·N/A·NCT00970450·16 enrolled

Analgesic Use for Pain Relief in Scorpion Sting

Completed·—·N/A·NCT05125796·106 enrolled

Concentration2 trials

At What Time Therapeutic Plasma Concentrations of Paracetamol Are Achieved in Two Marketed Formulations

Completed· GSK logo

GSK·Phase 1·NCT01551836·12 enrolled

Detection of Paracetamol Concentration in Blood-, Saline- and Urine Samples - a Validation Study for a Novel Technique

Completed·JJohanna Kujala·N/A·NCT04690673·12 enrolled

Acute Postoperative Pain2 trials

Comparison of the Effectiveness of Preemptive Paracetamol and Ibuprofen in Acute Postoperative Pain

Unknown status·—·Phase 4·NCT03063658·108 enrolled

Oral Use of Dexketoprofen/Tramadol for Acute Postoperative Pain in Total Hip Replacement With a Direct Anterior Approach.

Completed·KKAT General Hospital·Phase 2·NCT04178109·226 enrolled

COVID-192 trials

Four Different Experimental Drug Regimens to Standard of Care for the Treatment of Symptomatic Outpatients With COVID-19

Completed·SShin Poong Pharmaceutical Co. Ltd.·Phase 2·NCT04532931·192 enrolled

Effect of Kunamin in SARS-CoV-2 RT-PCR Positive Covid-19 Patients

Completed·RRAAS Nutritionals, LLC·Phase 3·NCT05417997·71 enrolled

Total Hip Arthroplasty2 trials

Study to Evaluate The Analgesic Efficacy and Safety of Intravenous Paracetamol in Subjects With Postoperative Pain After Total Hip Arthroplasty

Completed· Bristol-Myers Squibb logo

Bristol-Myers Squibb·Phase 4·NCT00344045·86 enrolled

Effect of Combinations of Paracetamol, Ibuprofen, and Dexamethasone on Patient-Controlled Morphine Consumption in the First 24 Hours After Total Hip Arthroplasty

Completed·NNaestved Hospital·Phase 4·NCT04123873·1,060 enrolled

Dementia2 trials

Pain in Patients With Dementia and Behavioural Disturbances

Completed·UUniversity of Bergen·Phase 2/3·NCT01021696·352 enrolled

Efficacy of Pain Treatment on Depression in Patients With Dementia

Completed·UUniversity of Bergen·Phase 4·NCT02267057·163 enrolled

Dexmedetomidine2 trials

Lidocaine, Paracetamol, and Dexmedetomidine for Rocuronium Injection Pain

Not yet recruiting·—·Phase 4·NCT07169227·170 enrolled

Intranasal Dexmedetomidine Versus Oral Paracetamol as a Pre-anaesthetic Medication in Pediatric Age Group

Completed·—·Phase 2·NCT04949477·86 enrolled

Malaria2 trials

Effect of Paracetamol on Renal Function in Plasmodium Knowlesi Malaria

Completed·MMenzies School of Health Research·Phase 3·NCT03056391·360 enrolled

Effect of Paracetamol on Kidney Function in Severe Malaria

Unknown status·UUniversity of British Columbia·Phase 3·NCT04251351·460 enrolled

Dexamethasone2 trials

Perineural Dexamethasone in Femural Nerve Block After Ligament Reconstruction

Completed·FFoisor Orthopedics Clinical Hospital·Phase 3·NCT02749162·90 enrolled

Perineural Low-dose Dexamethasone Added to Infraclavicular Block Anesthesia

Completed·FFoisor Orthopedics Clinical Hospital·Phase 3·NCT02698995·180 enrolled

Efficacy2 trials

Efficacy and Tolerability of Buscopan Plus in Painful Gastric or Intestinal Spasms

Completed· Boehringer Ingelheim logo

Boehringer Ingelheim·Phase 2·NCT02229786·1,637 enrolled

Efficacy of Ginger Extract (Compare Between the Ginger Preparation of Ancient Concept of Thai Traditional Practitioner, Standard Drug and Placebo) by Using Pain Score to Evaluate After Pain of Three Groups of First Normal Postpartum Women.

Completed·TThammasat University·Phase 1/2·NCT03617900·99 enrolled

Clinical Trial2 trials

Randomized Clinical Trial With Aminocaproic Acid in the Prevention of Exodontic Bleeding in Anticoagulants Patients

Unknown status·GGrupo de Estudos Multicentricos em Onco-Hematologia·Phase 4·NCT02238288·154 enrolled

PAracetamol and NSAID in Combination: A Randomised, Blinded, Parallel, 4-group Clinical Trial

Completed·DDaniel Hägi-Pedersen·Phase 4·NCT02571361·556 enrolled

Overweight1 trial

A Study of BGM0504 in Overweight or Obese Participants

Completed·BBrightGene Bio-Medical Technology Co., Ltd.·Phase 1·NCT06920056·28 enrolled

Microcirculation1 trial

Circulating Free Hemoglobin and Microcirculation After Administration of Paracetamol in Febrile Septic Patient

Completed·UUniversità Politecnica delle Marche··NCT02750163·50 enrolled

Blood-Brain Barrier1 trial

Blood-Brain Barrier Penetration of Therapeutic Agents in Human

Completed· Orion Corporation, Orion Pharma logo

Orion Corporation, Orion Pharma·Phase 1·NCT04571996·4 enrolled

Analgesic Efficacy1 trial

Analgesic Efficacy of Morphine Alone or Combined With Paracetamol and/or Ibuprofen for Long-bones Fractures in Children

Completed·AAssistance Publique - Hôpitaux de Paris·Phase 3·NCT02477007·304 enrolled

Local Anesthetic1 trial

Ibuprofen, Paracetamol Versus Placebo on Pain During Local Anesthetic Injection (RCT)

Unknown status·—·Phase 1/2·NCT03184649·52 enrolled

Diffuse Large B-Cell Lymphoma1 trial

A Study on Pharmacokinetics (PK), Efficacy and Safety of Subcutaneous (SC) Versus Intravenous (IV) Rituximab, in Combination With CHOP (Cyclophosphamide, Doxorubicin, Vincristine, Prednisone) in Previously Untreated Participants With CD20 Positive Diffuse Large B-Cell Lymphoma (DLBCL)

Completed· Roche logo

Roche·Phase 2·NCT04660799·50 enrolled

Medication1 trial

Paracetamol as Antipyretic and Analgesic Medication

Completed·UUniversity of Athens·Phase 4·NCT01070732·100 enrolled

Premedication1 trial

Oral Paracetamol Premedication Effect on Maternal Pain in Amniocentesis

Unknown status·DDepartment of Medical Services Ministry of Public Health of Thailand·N/A·NCT03035045·240 enrolled

Placebo Effect1 trial

Placebo Effect of Paracetamol in Healthy Volunteers

Completed·UUniversity Hospital, Clermont-Ferrand·Phase 1·NCT01053650·40 enrolled

Infusion1 trial

Management Of The Infusion-Associated Reactions In RRMS Patients Treated With LEMTRADA

Completed· Sanofi logo

Sanofi·Phase 4·NCT02205489·58 enrolled

General Anesthesia1 trial

Pain Management Following Dental Treatment Under General Anesthesia

Completed·KKing Abdullah University Hospital·N/A·NCT06574516·118 enrolled

Opioids1 trial

PARASTOP - Paracetamol With Strong Opioids

Completed·OOslo University Hospital·Phase 3·NCT05051735·204 enrolled

Multiple Sclerosis1 trial

A Study to Characterize Subcutaneous or Intravenous Alemtuzumab in Patients With Progressive Multiple Sclerosis

Completed· Sanofi logo

Sanofi·Phase 1·NCT02583594·24 enrolled

Tics1 trial

Effect of Paracetamol on Opicapone Pharmacokinetics in Healthy Volunteers

Completed·BBial - Portela C S.A.·Phase 1·NCT02305017·28 enrolled

Radius Fracture1 trial

Rebound Pain After Operations for Distal Radius Fractures With a Volar Plate in Brachial Plexus Block

Completed·OOslo University Hospital·Phase 3·NCT03011905·53 enrolled

Cryotherapy1 trial

Interest of Cryotherapy or Cortisone Aerosol Therapy in Early Post-operative Swallowing Disorders Following Total Thyroidectomy

Completed·—·N/A·NCT02855866·240 enrolled

Cognition1 trial

Exploratory Study to Investigate Cognition Function and Mobility in Individuals With Pain

Terminated· GSK logo

GSK·Phase 4·NCT02974114·21 enrolled

Septic Shock1 trial

Heamodynamic Effects of Paracetamol in Septic Shock Patients

Completed·AAyah Mohammed Khalil·Phase 4·NCT06076980·61 enrolled

Infants1 trial

The Preterm Infants' Paracetamol Study

Completed·UUniversity of Oulu·Phase 2·NCT01938261·120 enrolled

Gastrectomy1 trial

Pharmacokinetics of Paracetamol and Antiepileptic Drugs After Sleeve Gastrectomy

Terminated·RRambam Health Care Campus·Phase 4·NCT03161509·2 enrolled

After Cardiac Surgery1 trial

Multimodal Analgesic Treatment Versus Traditional Morphine Analgesia After Cardiac Surgery

Completed·RRigshospitalet, Denmark·Phase 4·NCT01966172·180 enrolled

Migraine1 trial

Comparison of Oral Paracetamol and Zolmitriptan Efficacy in the Treatment of Acute Migraine in Emergency Department

Completed·PPamukkale University·Phase 4·NCT03145467·200 enrolled

Abdominal Surgery1 trial

Lornoxicam vs. Paracetamol After Lower Abdominal Surgery

Completed·IImam Abdulrahman Bin Faisal University·Phase 4·NCT01564680·60 enrolled

Lumbar Erector Spinae Plane Block1 trial

Lumbar Erector Spinae Plane Block for Back Surgery

Unknown status·DDr M. B. Breebaart·Phase 3·NCT03825198·80 enrolled

Postoperative Pain Management1 trial

Morphine-sparing Effect of Intravenous Paracetamol for Post-operative Pain Management Following Laparoscopic Gastric Banding in Morbidly Obese Patients

Unknown status·SSoroka University Medical Center·N/A·NCT02154464·220 enrolled

Experimental1 trial

A Pharmacokinetic Study of an Experimental Paracetamol Formulation

Completed· GSK logo

GSK·Phase 1·NCT01476176·30 enrolled

Long-term Follow-up1 trial

Long-term Follow-up of Lichtenstein's Operation Versus Mesh Plug Repair

Completed·UUniversity Hospital, Basel, Switzerland·N/A·NCT01637818·594 enrolled

Opioid Consumption1 trial

Effect of Early Pain Management at Triage on Opioid Consumption

Completed·UUniversity of Monastir·N/A·NCT03243006·1,500 enrolled

Pacemaker1 trial

PECs Block for Pacemaker Insertion in Children

Completed·KKasr El Aini Hospital·Phase 4·NCT04931693·40 enrolled

Remifentanil1 trial

Remifentanil Versus Paracetamol for Pain Treatment External Cephalic Versions.

Completed·BBasque Health Service·Phase 3·NCT01048398·60 enrolled

Caesarean Section1 trial

Protective Analgesia in Caesarean Section Using Intravenous Paracetamol

Unknown status·—·N/A·NCT03060265·60 enrolled

Thoracic Paravertebral Block1 trial

Pain Control After Open Radical Nephrectomy: Thoracic Paravertebral Block Versus External Oblique Intercostal Block

Completed·HHacettepe University·N/A·NCT07071012·98 enrolled

Metabolism1 trial

Paracetamol Metabolism Research in Postoperative Hepatic Surgery

Completed·UUniversity Hospital, Lille·N/A·NCT03297073·90 enrolled

Pregnant Women1 trial

Transplacental Transfer of Drugs Used in Pregnant Women

Completed·UUniversity Hospital, Gasthuisberg·N/A·NCT02622802·250 enrolled

Common Cold1 trial

Effects of Two Doses of a Common Cold Treatment on Alertness

Completed· GSK logo

GSK·Phase 3·NCT01686646·240 enrolled

Major Trauma1 trial

Pain Multidisciplinar Intervention in Major Trauma Patients

Completed·NNuria Llorach-Perucho··NCT05355441·38 enrolled

Gastrointestinal1 trial

Gastrointestinal Safety Evaluation of Two Over the Counter Analgesics

Completed· GSK logo

GSK·Phase 4·NCT01822665·28 enrolled

Oxidative Stress1 trial

Paracetamol Effect on Oxidative Stress and Renal Function in Severe Malaria

Completed·UUniversity of Oxford·N/A·NCT01641289·62 enrolled

Pain and Discomfort1 trial

Strategy to Cope Pain and Discomfort in Mammography

Unknown status·—·N/A·NCT04381104·632 enrolled

Atrophic Scar1 trial

Simultaneous Versus Sequential Fractional CO2 Laser and Subcision Combination for Post-acne Atrophic Scars: A Split-face Comparative Study.

Completed·HHo Chi Minh City Hospital of Dermato-Venereology·N/A·NCT05688202·34 enrolled

Dysmenorrhea1 trial

Comparison of Dexketoprofen, Paracetamol and Ibuprofen in the Treatment of Primary Dysmenorrhea

Unknown status·PPamukkale University·N/A·NCT03697746·300 enrolled

Strabismus1 trial

Comparison Between Peribulbar And Sub-tenon Blocks on Oculocardiac Reflex (OCR) During Pediatric Strabismus Surgery

Unknown status·—·N/A·NCT06293586·140 enrolled

Randomized Controlled Trial1 trial

Large-scale Prospective Double-blind Randomized Controlled Trial of Pecs II Block for Breast Surgery

Completed·GGZA Ziekenhuizen Campus Sint-Augustinus·Phase 4·NCT02544282·140 enrolled

Morphine1 trial

IV Paracetamol vs IV Morphine vs Placebo in Sciatalgia

Unknown status·—·Phase 4·NCT02504996·300 enrolled

Pain Management1 trial

The Efficiency of Periarticular Multimodal Drug Injection in Pain Management Following Primary Unilateral TKA

Completed·—·N/A·NCT06112548·80 enrolled

Oral1 trial

Oral Pharmacokinetics of Sulfasalazine, Paracetamol, Fexofenadine and Valsartan Using Different Administration Mediums

Completed·UUniversity Medicine Greifswald·Phase 1·NCT03012763·9 enrolled

Postoperative Pain Relief1 trial

Pre-operative Analgesics for Postoperative Pain Relief After Dental Treatment

Completed·HHadassah Medical Organization·Phase 1·NCT02393339·114 enrolled

Myocardial Infarction1 trial

The Effect of Opioids on P2Y12 Receptor Inhibition in Patients With ST-Elevation Myocardial Infarction Who Are Pre-treated With Crushed Ticagrelor

Completed·AA.H. Tavenier·Phase 4·NCT03400267·200 enrolled

Effectiveness1 trial

Cost-effectiveness of Two Painkillers for Treating Pain After Limb Injuries

Completed·—·Phase 2·NCT00528658·782 enrolled

Bariatric Surgery1 trial

Comparisons of iv Ibuprofen and iv Paracetamol During Bariatric Surgery

Completed·IInonu University·Phase 4·NCT02778958·40 enrolled

Cesarean Delivery1 trial

TAP vs QLB in Patients After Cesarean Delivery

Completed·MMedical University of Lublin·Phase 4·NCT03404908·105 enrolled

Cleft Palate1 trial

Suprazygomatic Block in Cleft Palate Surgery in Children

Completed·—·Phase 2·NCT03412474·80 enrolled

Laparoscopic Cholecystectomy1 trial

Intraoperative Lidocaine Infusion vs. Esmolol Infusion for Postoperative Analgesia in Laparoscopic Cholecystectomy

Completed·—·Phase 4·NCT02327923·90 enrolled

Abdominal Aortic Aneurysm1 trial

Epidural Versus Wound Infusion Plus Morphine Bolus in Open Abdominal Aortic Aneurysm Repair

Completed·UUniversity of Genova·Phase 4·NCT02677532·51 enrolled

Gastric1 trial

Bioavailability of Paracetamol, Amoxicillin and Talinolol Before, Immediately and One Year After Gastric Bypass Operation

Completed·UUniversity Medicine Greifswald·Phase 1·NCT02514941·12 enrolled

Prematurity1 trial

Registration and Treatment of Pain During Eye Examination of Prematurity

Terminated·SSt. Olavs Hospital·N/A·NCT01552993·5 enrolled

Intraoperative1 trial

Pre-emptive Paracetamol for Prevention of Intraoperative Shoulder Tip Pain

Unknown status·—·Phase 2/3·NCT04038307·120 enrolled

Satisfaction1 trial

To Compare the Efficacy and Patients' Satisfaction for the Treatment of Post Cesarean Pain of Two Protocols: Oral Medications in Fixed Time Interval Administration Versus Spinal Morphine

Completed·HHaEmek Medical Center, Israel·N/A·NCT02440399·200 enrolled

MPA1 trial

Pharmacokinetic Study to Compare Two Formulations of Paracetamol

Completed· GSK logo

GSK·Phase 1·NCT01767428·30 enrolled

Age1 trial

Assessment of Use of Rapid Diagnostic Testing in the Context of Home Management With ACTs

Completed·—·N/A·NCT00720811·6,456 enrolled

Meningococcal Disease1 trial

Safety and Immunogenicity of an Investigational Pentavalent Meningococcal ABCYW Vaccine Against Meningococcal Disease in Children, Toddlers, and Infants

Active, not recruiting· Sanofi logo

Sanofi·Phase 1/2·NCT06647407·750 enrolled

Diverticulitis1 trial

Symptomatic Treatment of Acute Uncomplicated Diverticulitis

Completed·HHelsinki University Central Hospital·N/A·NCT02219698·158 enrolled

Thoracoscopic Surgery1 trial

A Study Investigating Pain Following Single-port or Multi-port Video Assisted Thoracoscopic Surgery

Withdrawn·UUniversity Hospitals Bristol and Weston NHS Foundation Trust·N/A·NCT02556970

Coronary Artery Disease1 trial

Paracetamol and Endothelial Function in Patients With Stable Coronary Artery Disease

Completed·UUniversity of Zurich·Phase 4·NCT00534651·37 enrolled

Humans1 trial

Variability of Sulfotransferase 1A1 Activity in Humans: an Approach to Improve Predictive Drug Response - Part I: Analysis of Intraindividual Variation in Healthy Adults

Completed·—·Phase 1·NCT03182595·36 enrolled

Acetaminophen1 trial

Paracetamol (Acetaminophen) for Closure of PDA in Preterm Infants

Completed·HHillel Yaffe Medical Center·Phase 3·NCT01755728·19 enrolled

Brain Injury1 trial

The Paracetamol AfteR Traumatic Brain InjurY Study

Completed·DDr. M.K. Saxena·Phase 2·NCT01231139·41 enrolled

Breast1 trial

Breastmilk Alone or in Combination With Paracetamol for Reducing Pain

Unknown status·—·Phase 4·NCT05354479·60 enrolled

Menopause1 trial

A Research Study Looking Into the Effect of NNC0519-0130 on Blood Levels of a Birth Control Pill and Emptying of the Stomach in Women After Menopause

Completed· Novo Nordisk logo

Novo Nordisk·Phase 1·NCT06513104·47 enrolled

Hypotensive Anesthesia1 trial

Effect of Local Anesthesia Versus Induced Hypotensive Anesthesia on Quality of External Dacryocystorhinostomy Operation

Unknown status·MMansoura University·N/A·NCT05241054·64 enrolled

Osteoarthritis1 trial

Assess the Blood-Oxygen-Level-Dependent (BOLD) Signal Changes in the Brain by Paracetamol as Measured by Functional Magnetic Resonance Imaging (fMRI) in Subjects With Osteoarthritis (OA)

Completed· GSK logo

GSK·Phase 4·NCT01105936·31 enrolled

Efficacy and Safety1 trial

Trauma Acute Pain Treatment With Methoxyflurane Vaporized (PENTHROX®): Efficacy and Safety Study (MEDITA)

Completed·MMundipharma Pharmaceuticals srl·Phase 3·NCT03585374·272 enrolled

CAR1 trial

Consequences of Doing What Should Not be Done in Primary Care

Completed·UUniversidad Miguel Hernandez de Elche··NCT03482232·750,000 enrolled

Hypertensive1 trial

Variability of Sulfotransferase Activity in Humans: an Approach to Improve Predictive Drug Response Part II: Analysis of Interindividual Variation in Hypertensive Patients

Completed·—·Phase 1·NCT06782204·7 enrolled

Asthma1 trial

The Effect of Single Dose Paracetamol on the Lower Airways of Asthmatic and Healthy Children

Unknown status·TTel-Aviv Sourasky Medical Center·N/A·NCT01073748·60 enrolled

Complication1 trial

Preoperative Dose of Co-amoxiclav for Prevention of Postoperative Complications in Dentoalveolar Surgery

Unknown status·TTaibah University·N/A·NCT03844776·135 enrolled

Prevention1 trial

Prevention of Post-Operative Shivering

Completed·—·Phase 1·NCT04682743·120 enrolled

Toxicity1 trial

Paracetamol Toxicity in Septic Patients

Suspended·—·Phase 3·NCT01182974·80 enrolled

Interscalene Brachial Plexus Block1 trial

Ultrasound Guidance for Interscalene Brachial Plexus Block

Completed·UUniversity of Parma·Phase 4·NCT00702416·50 enrolled

Hypertension1 trial

PAracetamol Treatment in Hypertension: Effect on Blood Pressure (PATH-BP) Study

Completed·UUniversity of Edinburgh·Phase 4·NCT01997112·100 enrolled

Hypothermia1 trial

Paracetamol Hypothermia Children

Completed·—·Phase 4·NCT04608669·60 enrolled

Bacterial Meningitis1 trial

Oral Glycerol and High-Dose Rectal Paracetamol to Improve the Prognosis of Childhood Bacterial Meningitis

Completed·KKamuzu University of Health Sciences·Phase 3·NCT00619203·466 enrolled

Infiltration1 trial

Transversus Abdominis Plane Block Versus Wound Infiltration for Postcesarean Analgesia

Completed·MMansoura University·N/A·NCT02691572·80 enrolled

Abortion1 trial

Comparison Between Two Analgesic Methods for Pain Relief Following Surgical Abortion

Unknown status·RRambam Health Care Campus·N/A·NCT02025166·82 enrolled

Radiofrequency Ablation1 trial

A Trial of Intravenous Paracetamol vs. Placebo in Patients Receiving Radiofrequency Ablation of the Medial Branch Facet Nerve

Unknown status·SSheba Medical Center·N/A·NCT02539979·50 enrolled

Femur Fracture1 trial

Analgesic Effect of Paracetamol in Patients With Femur Fracture: is Intravenous Better Than Oral?

Completed·FFondazione Policlinico Universitario Agostino Gemelli IRCCS··NCT05025228·170 enrolled

Type 2 Diabetes1 trial

Effect of Liraglutide on Absorption of Paracetamol in Subjects With Type 2 Diabetes

Completed· Novo Nordisk logo

Novo Nordisk·Phase 1·NCT01517555·18 enrolled

Pneumothorax1 trial

Does Non-Steroidal Anti-inflammatory Drugs Decrease the Quality of Pleurodesis After Mechanical Pleural Abrasion/Pleurectomy for Treatment of Pneumothorax?

Recruiting·—·Phase 1/2·NCT06467318·116 enrolled

Insulin Secretion1 trial

Effect of Food Composition on Postprandial Insulin Secretion in Neonatal Diabetes

Completed·RRoyal Devon and Exeter NHS Foundation Trust·N/A·NCT02921906·16 enrolled

Sciatica1 trial

Comparison of Intravenous Ibuprofen and Paracetamol in Patients With Sciatica Presented to the Emergency Department

Unknown status·PPamukkale University·Phase 4·NCT02777320·120 enrolled

Tramadol1 trial

Tramadol vs.Tramadol With Paracetamol

Completed·YYeditepe University Hospital·N/A·NCT03482492·60 enrolled

Pilot Study1 trial

Feasibility of n-of-1 Trials - a Pilot Study

Completed·UUniversity of Bristol·Phase 2·NCT00371696·10 enrolled

Video-Assisted Thoracoscopic Surgery1 trial

Comparison Paravertebral and Serratus Anterior Plane Block in Video-assisted Thoracoscopic Surgery.

Active, not recruiting·HHacettepe University·N/A·NCT07002788·122 enrolled

Knee Arthroscopy1 trial

Safety and Effectiveness of Tramadex-OD After Knee Arthroscopy

Unknown status·SShaare Zedek Medical Center·N/A·NCT01024348·100 enrolled

Retinopathy of Prematurity1 trial

The Efficacy of Paracetamol in Reducing Pain During Ophthalmological Examination for Retinopathy of Prematurity: a Prospective Randomised Trial

Unknown status·—·N/A·NCT01872871·80 enrolled

Third Molar Surgery1 trial

Pre Emptive Analgesics for Pain Relief in Impacted Lower Third Molar Surgery

Completed·MMelaka Manipal Medical College·Phase 4·NCT04769557·60 enrolled

Vaginal Delivery1 trial

Is Paracetamol an Effective Treatment for Chronic Moderate Pain in the Newborn After Operative Vaginal Delivery?

Completed·UUniversity Hospital, Basel, Switzerland·Phase 4·NCT00488540·280 enrolled

Gingival Recession1 trial

Clinical Evaluation of Single-stage Advanced Versus Rotated Flaps in the Treatment of Gingival Recessions

Completed·UUniversidade Federal Fluminense·Phase 4·NCT02433912·36 enrolled

Quadratus Lumborum Block1 trial

Quadratus Lumborum Block vs Transversus Abdominis Plane Block for Post-cholecystectomy Analgesia

Completed·MMansoura University·N/A·NCT03323684·159 enrolled

Epidural Analgesia1 trial

Supplementary Epidural Analgesia in Video-Assisted Thoracic Surgery (VATS) - The SEAVATS Study

Completed·OOdense University Hospital·Phase 4·NCT02359175·161 enrolled

Lumbar Disc Surgery1 trial

Efficacy of Intravenous Ibuprofen and Paracetamol on Postoperative Pain and Morphine Consumption in Lumbar Disc Surgery

Completed·IInonu University·N/A·NCT03437707·3 enrolled

Inguinal hernia1 trial

Comparison of Lornoxicam and Paracetamol for Pre-emptive Intravenous Analgesia for Elective Inguinal Hernia Repair

Unknown status·—·Phase 3·NCT01069055·60 enrolled

Unspecified6 trials

Pharmacokinetic Study of Paracetamol.

Unknown status·KKolding Sygehus·Phase 1·NCT03953287·12 enrolled

ESP vs ESP With PECS

Completed·MMedical University of Lublin·Phase 4·NCT03592485·33 enrolled

Paracetamol and Metamizole With SPI-guided Anaesthesia for VRS

Completed·MMedical University of Silesia·N/A·NCT03389243·165 enrolled

Show 3 more trials

Paracetamol and Glutathion

Completed·UUniversity Hospital, Clermont-Ferrand·Phase 1·NCT01116596·18 enrolled

Different Peribulbar Blocks With SPI-guided Anaesthesia for VRS (P&MSPIVRS)

Completed·MMedical University of Silesia·N/A·NCT03413371·184 enrolled

Antipyretic Therapy With and Without Cold Sponging

Not yet recruiting·MMuhammad Aamir Latif·N/A·NCT07426744·210 enrolled

Sources

References

[1]
ClinicalTrials.gov — 328 trial records for Paracetamol. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — Paracetamol compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for Paracetamol. EMBL-EBI & Wellcome Sanger Institute.
[4]
SEC EDGAR — GSK company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[2]
Highest Phase: Phase 3[1]
Company: GSK