Paracetamol

Phase 3Small molecule

GSK

Paracetamol is one of 288 small molecule programs targeting Rib Fracture. It is currently in Phase 3.

Indications

335

Total Trials

Active Trials

287

Competitors

Pipeline

Status by Indication[3][1]

Indication

Rib FractureActive, not recruiting

Insulin SecretionActive, not recruiting

AbortionActive, not recruiting

DysmenorrheaActive, not recruiting

Retinopathy of PrematurityActive, not recruiting

UrolithiasisNot yet recruiting

Relapsing-Remitting Multiple SclerosisActive, not recruiting

DiverticulitisActive, not recruiting

Femur FractureActive, not recruiting

HysterectomyActive, not recruiting

Rib FracturePreclinical

Active, not recruiting

Insulin SecretionPreclinical

Active, not recruiting

AbortionPreclinical

Active, not recruiting

DysmenorrheaPreclinical

Active, not recruiting

Retinopathy of PrematurityPreclinical

Active, not recruiting

UrolithiasisPhase 3

Not yet recruiting

Relapsing-Remitting Multiple SclerosisPhase 3

Active, not recruiting

DiverticulitisPreclinical

Active, not recruiting

Femur FracturePreclinical

Active, not recruiting

HysterectomyPreclinical

Active, not recruiting

Showing 10 of 22 indications

Competition

Competitive Landscape

706 competitors in Breast Cancer

#DrugCompanyPhaseTrials

Paracetamol

GSK

Phase 3

1 2

Blenoxane

Bristol-Myers Squibb

Preclinical

1 3

Lexiscan

Astellas

Preclinical

1 4

Voltaren

Novartis

Preclinical

1 5

Spravato

WWim Janssens

Preclinical

2 6

Sporanox

SSebela Pharmaceuticals Development LLC

Preclinical

1 7

Nubain

AAultman Health Foundation

Preclinical

1 8

Feraheme

AAzurity Pharmaceuticals

Preclinical

1 9

Rilvegostomig

AstraZeneca

Preclinical

1 10

Systemic Therapy

Bristol-Myers Squibb

Preclinical

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q2 2027

N/ANot yet recruiting

Breast Cancer

NCT07197684

Phase 1/2Active, not recruiting

Meningococcal Disease

NCT06647407

Clinical

Trials by Indication[1]

Treatment7 trials

Effects Of Native Collagen Type 2 Treatment

Completed·EEskisehir Osmangazi University·N/A·NCT02237989·39 enrolled

Treatment Of Fever In The Emergency Department

Completed·FFondazione Policlinico Universitario Agostino Gemelli IRCCS··NCT05814302·324 enrolled

Operative Treatment of Unstable Thoracic Cage Injuries and Chest Wall Deformity in Trauma

Completed·SSahlgrenska University Hospital·N/A·NCT02132416·92 enrolled

Show 4 more trials

Prophylactic Antipyretic Treatment in Children Receiving Pneumococcal Conjugate and Standard Infant Vaccines

Completed· GSK logo

GSK·Phase 3·NCT00370318·400 enrolled

Early Treatment Versus Expectant Management of PDA in Preterm Infants

Completed·LLviv National Medical University·N/A·NCT03860428·208 enrolled

Prophylactic Antipyretic Treatment in Children Receiving Booster Dose of Pneumococcal Conjugate Vaccine GSK1024850A

Completed· GSK logo

GSK·Phase 3·NCT00496015·750 enrolled

Safety of Paracetamol as Antipyretic in Treatment of Dengue Infection in Adults

Completed·PPhramongkutklao College of Medicine and Hospital·N/A·NCT02833584·123 enrolled

Headache6 trials

Effects of Preemptive Paracetamol and Ibuprofen on Headache and Myalgia in Patients After Electroconvulsive Therapy

Completed·IInonu University·N/A·NCT03783312·60 enrolled

Different Approaches for the Management of Post-dural Puncture Headache

Completed·BBahaa Mohammed Refaie·N/A·NCT05253014·120 enrolled

Clinical Study to Evaluate Efficacy of New Paracetamol Formulation Compared to Ibuprofen in Headache

Terminated· GSK logo

GSK·Phase 3·NCT01842633·365 enrolled

Show 3 more trials

Paracetamol With Caffeine to Treat Episodic Tension Type Headache

Terminated· GSK logo

GSK·Phase 2/3·NCT01755702·66 enrolled

Comparison of Drugs on Headache Treatment After ECT Treatment

Unknown status·MMustafa Kemal University·Phase 4·NCT03830398·225 enrolled

Sphenopalatine Ganglion Block for Management of Post- Dural Puncture Headache in Obstetric Patients

Completed·—·N/A·NCT04793490·40 enrolled

Patent ductus arteriosus5 trials

Platelet Transfusion for Treatment of Patent Ductus Arteriosus in Thrombocytopenic Preterm Neonates

Completed·PPost Graduate Institute of Medical Education and Research, Chandigarh·Phase 3·NCT03022253·44 enrolled

Adding Paracetamol to Ibuprofen for Treatment of Patent Ductus Arteriosus in Preterm Infants

Completed·RRambam Health Care Campus·Phase 2/3·NCT02002741·24 enrolled

Paracetamol in Patent Ductus Arteriosus

Completed·AAziende Chimiche Riunite Angelini Francesco S.p.A·Phase 2·NCT02422966·110 enrolled

Show 2 more trials

Assessment of Therapeutic Effect of Rectal Vs. Intravenous Paracetamol in The Treatment of Patent Ductus Arteriosus (PDA) in Neonates

Unknown status·SSoha mahmoud Hussien mahdy·Phase 1/2·NCT06256211·100 enrolled

Paracetamol and Patent Ductus Arteriosus (PDA)

Unknown status·SShaare Zedek Medical Center·Phase 2·NCT01291654·80 enrolled

Analgesic5 trials

The Central Analgesic Effects of Paracetamol on Serotonergic Pathways

Completed·UUniversity Hospital, Basel, Switzerland·N/A·NCT00970450·16 enrolled

Mental Effects of Analgesic Drugs: Paracetamol and Ibuprofen

Unknown status·—·Phase 1·NCT04424420·150 enrolled

Analgesic Effect of a New Analgesic Based Gel(Douloff) Versus Oral Paracetamol in Acute Soft Injuries

Unknown status·UUniversity of Monastir·Phase 1·NCT05647681·1,100 enrolled

Show 2 more trials

Analgesic Use for Pain Relief in Scorpion Sting

Completed·—·N/A·NCT05125796·106 enrolled

Visualisation of the Central Analgesic Effect of Paracetamol in Functional MRI

Completed·UUniversity Hospital, Clermont-Ferrand·Phase 1·NCT01562704·21 enrolled

Common Cold5 trials

Placebo and Active Controlled Study to Compare the Efficacy of Aspirin and Paracetamol in Treatment of Sore Throat Associated With a Common Cold

Completed· Bayer logo

Bayer·Phase 4·NCT01465009·508 enrolled

Effects of Two Doses of a Common Cold Treatment on Alertness

Completed· GSK logo

GSK·Phase 3·NCT01686646·240 enrolled

Evaluation of the Efficacy and Safety of Two Ibuprofen Combination Products for the Treatment of the Common Cold and Flu in Latin America

Withdrawn· Pfizer logo

Pfizer·Phase 3·NCT01938144

Show 2 more trials

Effects of a Common Cold Treatment on Cognitive Function

Completed· GSK logo

GSK·Phase 4·NCT01466348·72 enrolled

Efficacy and Safety of the Combination of Acetylcysteine, Paracetamol and Phenylephrine for the Treatment of Common Cold

Withdrawn· Novartis logo

Novartis·Phase 3·NCT05070650

120 more indications

Post Operative Pain5 trials

Intravenous Paracetamol for Postoperative Pain

Completed·LLithuanian University of Health Sciences·Phase 4·NCT02248493·54 enrolled

Codeine Plus Paracetamol Versus Placebo for PRK Post-operative Pain

Completed·UUniversity of Sao Paulo General Hospital·Phase 3·NCT02625753·40 enrolled

Effectiveness of Pre-emptive Analgesics on Post-Operative Pain After Stainless Steel Crown Placement On Primary Molars

Completed·—·Phase 4·NCT05602064·66 enrolled

Show 2 more trials

Efficacy of Intravenous Ibuprofen and Paracetamol on Postoperative Pain and Tramadol Consumption in Shoulder Surgery

Completed·—·N/A·NCT05401916·2 enrolled

The Effect of Dexamethasone in Combination With Paracetamol and Ibuprofen on Postoperative Pain After Spine Surgery

Completed·RRigshospitalet, Denmark·Phase 4·NCT01953978·160 enrolled

Intravenous5 trials

Pharmacokinetics, -Dynamics and Safety of Intravenous Paracetamol in Neonates

Completed·UUniversitaire Ziekenhuizen KU Leuven·Phase 2/3·NCT00969176·60 enrolled

Comparison of the Efficacy of Intravenous Dexketoprofen and Paracetamol in the Treatment of Sore Throat

Completed·PPamukkale University·Phase 4·NCT03768882·200 enrolled

Intravenous Paracetamol or Morphine for the Treatment of Acute Flank Pain

Completed·PPamukkale University·Phase 4·NCT01318187·73 enrolled

Show 2 more trials

Preemptive Analgesia Using Intravenous Paracetamol

Completed·—·N/A·NCT02884921·87 enrolled

Efficacy of Intravenous (IV) Paracetamol for Treatment of Acute Pain

Completed·TTehran University of Medical Sciences·Phase 4·NCT01465984·60 enrolled

Pain Management3 trials

NSAIDs Versus Paracetamol Versus Paracetamol + NSAIDs in Traumatic Pain Management

Completed·UUniversity of Monastir·Phase 3·NCT03222518·1,500 enrolled

Efficacy Study of Different Analgesic Options in Kidney Stone Pain Management

Completed·HHamad Medical Corporation·Phase 4·NCT02187614·1,645 enrolled

The Efficiency of Periarticular Multimodal Drug Injection in Pain Management Following Primary Unilateral TKA

Completed·—·N/A·NCT06112548·80 enrolled

Interaction3 trials

The Median Effective Dose (ED50) of Paracetamol and Morphine : A Study of Interaction Study

Completed·PProcare Riaya Hospital·N/A·NCT01366313·90 enrolled

Clinical Confirmation of a Pharmacodynamic Interaction Between Tropisetron and Paracetamol

Completed·UUniversity Hospital, Clermont-Ferrand·Phase 4·NCT00487110·40 enrolled

Drug Interaction Between Paracetamol and Warfarin

Completed·HHopital Lariboisière·Phase 4·NCT01104337·45 enrolled

Osteoarthritis3 trials

Structured Treatment of Osteoarthritis of the Knee With or Without Total Knee Replacement

Completed·NNorthern Orthopaedic Division, Denmark·N/A·NCT01410409·100 enrolled

Assess the Blood-Oxygen-Level-Dependent (BOLD) Signal Changes in the Brain by Paracetamol as Measured by Functional Magnetic Resonance Imaging (fMRI) in Subjects With Osteoarthritis (OA)

Completed· GSK logo

GSK·Phase 4·NCT01105936·31 enrolled

Structured Non-operative Treatment of Knee Osteoarthritis

Completed·NNorthern Orthopaedic Division, Denmark·N/A·NCT01535001·100 enrolled

Dysmenorrhea3 trials

IV Paracetamol Versus IV Dexketoprofen in Dysmenorrhea

Unknown status·—·Phase 4·NCT02373514·100 enrolled

Intravenous Tramadol Versus Intravenous Paracetamol in Patients With Dysmenorrhea

Completed·—·Phase 4·NCT03509740·100 enrolled

Comparison of Dexketoprofen, Paracetamol and Ibuprofen in the Treatment of Primary Dysmenorrhea

Unknown status·PPamukkale University·N/A·NCT03697746·300 enrolled

Ibuprofen3 trials

Population Pharmacokinetics and Dosage Individualization of Paracetamol and Ibuprofen in Children With PDA

Unknown status·SShandong University··NCT04397913·500 enrolled

Ibuprofen and Paracetamol Pharmacokinetic Study

Completed·RReckitt Benckiser Healthcare (UK) Limited·Phase 1·NCT02452450·43 enrolled

Paracetamol Versus Ibuprofen for PDA Closure

Unknown status·—·Phase 4·NCT03265782·30 enrolled

Postoperative Analgesia3 trials

Perioperative Electroacupuncture on Postoperative Analgesia in Prostatectomy

Completed·GG.Gennimatas General Hospital·Phase 4·NCT01526525·70 enrolled

Controlled-Release Oxycodone For Postoperative Analgesia After Video-Assisted Thoracic Surgery

Terminated·UUniversity of Parma·Phase 4·NCT00681174·22 enrolled

Intravenous Paracetamol Compared Dexketoprofen for Postoperative Analgesia After Septoplasty

Unknown status·—·Phase 3·NCT02602197·2 enrolled

Low back pain3 trials

Magnesium Oral Supplementation for Acute Non-specific Low Back Pain

Completed·IIstanbul University·N/A·NCT04626063·240 enrolled

IV Paracetamol, Dexketoprofen or Morphine for the Treatment of Low Back Pain

Completed·PPamukkale University·Phase 4·NCT01422291·120 enrolled

Paracetamol, Dexketoprofen and Ibuprofen In Non-Traumatic Acute Low Back Pain

Completed·PPamukkale University·Phase 4·NCT04609254·210 enrolled

Cancer Pain3 trials

Paracetamol Versus Placebo in Conjunction With Strong Opioids for Cancer Pain

Terminated·UUniversity of Edinburgh·N/A·NCT02706769·34 enrolled

Paracetamol in Addition to WHO Step III Opioids in Chronic Cancer Pain Control

Recruiting·IInsel Gruppe AG, University Hospital Bern·Phase 4·NCT05088876·140 enrolled

Paracetamol for Cancer Pain

Unknown status·—·Phase 4·NCT01313247·50 enrolled

Knee Arthroscopy2 trials

Ultrasound-guided Blocks for Ambulatory Knee Arthroscopy

Completed·JJens Borglum Neimann·Phase 4·NCT01837394·60 enrolled

Safety and Effectiveness of Tramadex-OD After Knee Arthroscopy

Unknown status·SShaare Zedek Medical Center·N/A·NCT01024348·100 enrolled

Gastrointestinal2 trials

Gastrointestinal Nutrient Transit and Enteroendocrine Function After Upper Gastrointestinal Surgery

Completed·SSt. James's Hospital, Ireland··NCT03734627·40 enrolled

Gastrointestinal Safety Evaluation of Two Over the Counter Analgesics

Completed· GSK logo

GSK·Phase 4·NCT01822665·28 enrolled

Musculoskeletal Pain2 trials

Comparison of Efficacy of Intravenous Paracetamol and Dexketoprofen for Acute Traumatic Musculoskeletal Pain

Completed·PPamukkale University·Phase 4·NCT03428503·200 enrolled

Comparison of Efficacy of Intravenous Paracetamol and Dexketoprofen for Acute Nontraumatic Musculoskeletal Pain

Completed·PPamukkale University·Phase 4·NCT03122314·200 enrolled

Respiratory tract infection2 trials

Comparison of the Efficacy of Intravenous Paracetamol and Ibuprofen in the Treatment of Fever Due to Upper Respiratory Tract Infection

Completed·PPamukkale University·Phase 4·NCT03918135·200 enrolled

Placebo and Active Controlled Study to Compare the Antipyretic Efficacy of Aspirin® in Patients With Acute Febrile Upper Respiratory Tract Infections Suspected to be of Viral Origin

Completed· Bayer logo

Bayer·Phase 4·NCT01464944·392 enrolled

After Cardiac Surgery2 trials

Multimodal Analgesic Treatment Versus Traditional Morphine Analgesia After Cardiac Surgery

Completed·RRigshospitalet, Denmark·Phase 4·NCT01966172·180 enrolled

Morphine IV vs Paracetamol IV in Neonates and Infants After Cardiac Surgery

Completed·EErasmus Medical Center·N/A·NCT05853263·208 enrolled

Spinal Anesthesia2 trials

Prophylactic Paracetamol or Dexamethasone for Post-spinal Anesthesia Shivering

Completed·—·Phase 4·NCT03679065·300 enrolled

Paracetamol Versus Dipyrone After Pediatric Lower Abdominal Surgery in Children With Spinal Anesthesia

Completed·—·Phase 2·NCT01858402·2 enrolled

Pain2 trials

Pain Relief After Corneal Collagen Cross-Linking

Unknown status·—·Phase 1·NCT06212830·51 enrolled

Pain and Suction Curettage

Completed·GGökhan Açmaz·N/A·NCT01947205·111 enrolled

Tonsillectomy2 trials

Effect of Steroids on Post-tonsillectomy Morbidities

Completed·KKing Fahd General Hospital·Phase 2·NCT02401529·100 enrolled

Preemptive Dexamethasone , Paracetamol on Postoperative Period Following Adeno-tonsillectomy in Pediatric .

Completed·—·Phase 2·NCT05143762·90 enrolled

Abortion2 trials

Postoperative Pain After Medical Abortion Under Local Anesthesia : Comparison of Several Analgesic Regimen

Completed·UUniversity Hospital, Angers·N/A·NCT00188071·240 enrolled

Comparison Between Two Analgesic Methods for Pain Relief Following Surgical Abortion

Unknown status·RRambam Health Care Campus·N/A·NCT02025166·82 enrolled

AIN2 trials

The Effect of Paracetamol on Brain Temperature

Completed·FFondation Ophtalmologique Adolphe de Rothschild·Phase 4·NCT03648021·100 enrolled

Measuring Blood Flow in the Brain After Epileptic Activity

Completed·RRijnstate Hospital·Phase 2·NCT04028596·34 enrolled

Experimental2 trials

A Pharmacokinetic Study of an Experimental Paracetamol Formulation

Completed· GSK logo

GSK·Phase 1·NCT01476176·30 enrolled

A Pharmacokinetic Study Investigating the Rate and Extent of Paracetamol Absorption of Three Experimental Sustained Release Pediatric Suspensions

Completed· GSK logo

GSK·Phase 1·NCT01476215·18 enrolled

Concentration2 trials

At What Time Therapeutic Plasma Concentrations of Paracetamol Are Achieved in Two Marketed Formulations

Completed· GSK logo

GSK·Phase 1·NCT01551836·12 enrolled

Detection of Paracetamol Concentration in Blood-, Saline- and Urine Samples - a Validation Study for a Novel Technique

Completed·JJohanna Kujala·N/A·NCT04690673·12 enrolled

Renal Colic2 trials

Oral NSAI Versus Paracetamol or Placebo as a Second Line Treatment for Renal Colics

Completed·UUniversity of Monastir·Phase 3·NCT02304783·1,400 enrolled

Parecoxib vs Paracetamol in the Treatment of Acute Renal Colic

Completed·MMansoura University·Phase 4·NCT03704623·200 enrolled

Acute Postoperative Pain2 trials

Comparison of the Effectiveness of Preemptive Paracetamol and Ibuprofen in Acute Postoperative Pain

Unknown status·—·Phase 4·NCT03063658·108 enrolled

Oral Use of Dexketoprofen/Tramadol for Acute Postoperative Pain in Total Hip Replacement With a Direct Anterior Approach.

Completed·KKAT General Hospital·Phase 2·NCT04178109·226 enrolled

Efficacy2 trials

Efficacy of Ginger Extract (Compare Between the Ginger Preparation of Ancient Concept of Thai Traditional Practitioner, Standard Drug and Placebo) by Using Pain Score to Evaluate After Pain of Three Groups of First Normal Postpartum Women.

Completed·TThammasat University·Phase 1/2·NCT03617900·99 enrolled

Efficacy and Tolerability of Buscopan Plus in Painful Gastric or Intestinal Spasms

Completed· Boehringer Ingelheim logo

Boehringer Ingelheim·Phase 2·NCT02229786·1,637 enrolled

COVID-192 trials

Four Different Experimental Drug Regimens to Standard of Care for the Treatment of Symptomatic Outpatients With COVID-19

Completed·SShin Poong Pharmaceutical Co. Ltd.·Phase 2·NCT04532931·192 enrolled

A Study of a Candidate COVID-19 Vaccine (COV001)

Completed·UUniversity of Oxford·Phase 1/2·NCT04324606·1,077 enrolled

Total Hip Arthroplasty2 trials

Study to Evaluate The Analgesic Efficacy and Safety of Intravenous Paracetamol in Subjects With Postoperative Pain After Total Hip Arthroplasty

Completed· Bristol-Myers Squibb logo

Bristol-Myers Squibb·Phase 4·NCT00344045·86 enrolled

Effect of Combinations of Paracetamol, Ibuprofen, and Dexamethasone on Patient-Controlled Morphine Consumption in the First 24 Hours After Total Hip Arthroplasty

Completed·NNaestved Hospital·Phase 4·NCT04123873·1,060 enrolled

Cesarean Section2 trials

To Study and Evaluate the Effectiveness of Treatment by Percutaneous Electrical NeuroStimulation (PENS) for Post-operative Pain in Cesarean Section Patients Using Primary Relief v 2.0

Unknown status·DDyAnsys, Inc.·N/A·NCT03829774·22 enrolled

Preemptive Analgesia With Intravenous Paracetamol for Post-cesarean Section Pain Control

Completed·—·Phase 4·NCT02369133·60 enrolled

Influenza2 trials

The Benefit and Harm of Fever Suppression by Antipyretics in Influenza

Completed·TThe University of Hong Kong·Phase 4·NCT01891084·300 enrolled

Oseltamivir Versus Paracetamol for Influenza-like Illness During the Influenza Season

Unknown status·RRambam Health Care Campus·Phase 4·NCT03754686·436 enrolled

Dementia2 trials

Pain in Patients With Dementia and Behavioural Disturbances

Completed·UUniversity of Bergen·Phase 2/3·NCT01021696·352 enrolled

Efficacy of Pain Treatment on Depression in Patients With Dementia

Completed·UUniversity of Bergen·Phase 4·NCT02267057·163 enrolled

Dexmedetomidine2 trials

Lidocaine, Paracetamol, and Dexmedetomidine for Rocuronium Injection Pain

Not yet recruiting·—·Phase 4·NCT07169227·170 enrolled

Intranasal Dexmedetomidine Versus Oral Paracetamol as a Pre-anaesthetic Medication in Pediatric Age Group

Completed·—·Phase 2·NCT04949477·86 enrolled

Malaria2 trials

Effect of Paracetamol on Renal Function in Plasmodium Knowlesi Malaria

Completed·MMenzies School of Health Research·Phase 3·NCT03056391·360 enrolled

Antimalaria Drugs Susceptibility Testing for an Effective Management of Infected Patients in Sub-Sahara Africa

Completed·—·Phase 3·NCT02974348·300 enrolled

Dexamethasone2 trials

Perineural Dexamethasone in Femural Nerve Block After Ligament Reconstruction

Completed·FFoisor Orthopedics Clinical Hospital·Phase 3·NCT02749162·90 enrolled

Perineural Low-dose Dexamethasone Added to Infraclavicular Block Anesthesia

Completed·FFoisor Orthopedics Clinical Hospital·Phase 3·NCT02698995·180 enrolled

Vascular Function1 trial

Effects of Opioids and NSAIDs on Sympathetic Nervous System and Vascular Function

Recruiting·UUniversity of Zurich·Phase 4·NCT03781544·90 enrolled

General Anesthesia1 trial

Pain Management Following Dental Treatment Under General Anesthesia

Completed·KKing Abdullah University Hospital·N/A·NCT06574516·118 enrolled

Analgesia1 trial

Efficacy of Paracetamol in Addition to Morphine to Improve Analgesia in the Emergency Department

Completed·BBruno Minotti·Phase 4·NCT03843281·222 enrolled

Labor Analgesia1 trial

Epidural Tap in Labor Analgesia FOR LABOR ANALGESIA

Completed·MMedipol University·N/A·NCT05499234·70 enrolled

Opioids1 trial

PARASTOP - Paracetamol With Strong Opioids

Completed·OOslo University Hospital·Phase 3·NCT05051735·204 enrolled

Multiple Sclerosis1 trial

A Study to Characterize Subcutaneous or Intravenous Alemtuzumab in Patients With Progressive Multiple Sclerosis

Completed· Sanofi logo

Sanofi·Phase 1·NCT02583594·24 enrolled

Ketorolac1 trial

Adjuncts to IVRA, a Comparison Between Ketorolac and Paracetamol

Completed·—·Phase 3·NCT03485625·60 enrolled

Tics1 trial

Effect of Paracetamol on Opicapone Pharmacokinetics in Healthy Volunteers

Completed·BBial - Portela C S.A.·Phase 1·NCT02305017·28 enrolled

Radius Fracture1 trial

Rebound Pain After Operations for Distal Radius Fractures With a Volar Plate in Brachial Plexus Block

Completed·OOslo University Hospital·Phase 3·NCT03011905·53 enrolled

Cryotherapy1 trial

Interest of Cryotherapy or Cortisone Aerosol Therapy in Early Post-operative Swallowing Disorders Following Total Thyroidectomy

Completed·—·N/A·NCT02855866·240 enrolled

Cognition1 trial

Exploratory Study to Investigate Cognition Function and Mobility in Individuals With Pain

Terminated· GSK logo

GSK·Phase 4·NCT02974114·21 enrolled

Septic Shock1 trial

Heamodynamic Effects of Paracetamol in Septic Shock Patients

Completed·AAyah Mohammed Khalil·Phase 4·NCT06076980·61 enrolled

Infants1 trial

The Preterm Infants' Paracetamol Study

Completed·UUniversity of Oulu·Phase 2·NCT01938261·120 enrolled

Gastrectomy1 trial

Pharmacokinetics of Paracetamol and Antiepileptic Drugs After Sleeve Gastrectomy

Terminated·RRambam Health Care Campus·Phase 4·NCT03161509·2 enrolled

Migraine1 trial

Comparison of Oral Paracetamol and Zolmitriptan Efficacy in the Treatment of Acute Migraine in Emergency Department

Completed·PPamukkale University·Phase 4·NCT03145467·200 enrolled

Abdominal Surgery1 trial

Lornoxicam vs. Paracetamol After Lower Abdominal Surgery

Completed·IImam Abdulrahman Bin Faisal University·Phase 4·NCT01564680·60 enrolled

Vaccination1 trial

Primary and Booster Vaccination Study With Pneumococcal Vaccine GSK1024850A and Prophylactic Antipyretic Treatment

Completed· GSK logo

GSK·Phase 4·NCT01235949·850 enrolled

Emergencies1 trial

Paracetamol Vs Caffeine Vs Codeine in the Management of Post Traumatic Pain in Emergencies

Completed·UUniversity of Monastir·Phase 3·NCT05229965·1,500 enrolled

Temporomandibular Disorder1 trial

Evaluation of the Efficacy of Different Drugs in the Treatment of the Pain in Patients With Temporomandibular Disorder

Completed·YYuzuncu Yil University·Phase 4·NCT05529290·200 enrolled

Post Operative Sore Throat1 trial

Combined Effect of Dexamethasone and Paracetamol for Postoperative Sore Throat

Unknown status·SSeoul National University Hospital·N/A·NCT02252419·242 enrolled

Labor Pain1 trial

Oral Paracetamol as Preemptive Analgesia for Labor Pain

Completed·—·Phase 3·NCT01817829·100 enrolled

SARS CoV 2 Infection1 trial

Early Treatment of Vulnerable Individuals With Non-Severe SARS-CoV-2 Infection

Unknown status·AANRS, Emerging Infectious Diseases·Phase 2/3·NCT04920838·600 enrolled

Lumbar Erector Spinae Plane Block1 trial

Lumbar Erector Spinae Plane Block for Back Surgery

Unknown status·DDr M. B. Breebaart·Phase 3·NCT03825198·80 enrolled

Postoperative Pain Management1 trial

Morphine-sparing Effect of Intravenous Paracetamol for Post-operative Pain Management Following Laparoscopic Gastric Banding in Morbidly Obese Patients

Unknown status·SSoroka University Medical Center·N/A·NCT02154464·220 enrolled

Long-term Follow-up1 trial

Long-term Follow-up of Lichtenstein's Operation Versus Mesh Plug Repair

Completed·UUniversity Hospital, Basel, Switzerland·N/A·NCT01637818·594 enrolled

Opioid Consumption1 trial

Effect of Early Pain Management at Triage on Opioid Consumption

Completed·UUniversity of Monastir·N/A·NCT03243006·1,500 enrolled

Pacemaker1 trial

PECs Block for Pacemaker Insertion in Children

Completed·KKasr El Aini Hospital·Phase 4·NCT04931693·40 enrolled

Remifentanil1 trial

Remifentanil Versus Paracetamol for Pain Treatment External Cephalic Versions.

Completed·BBasque Health Service·Phase 3·NCT01048398·60 enrolled

Caesarean Section1 trial

Protective Analgesia in Caesarean Section Using Intravenous Paracetamol

Unknown status·—·N/A·NCT03060265·60 enrolled

Menopause1 trial

A Research Study Looking Into the Effect of NNC0519-0130 on Blood Levels of a Birth Control Pill and Emptying of the Stomach in Women After Menopause

Completed· Novo Nordisk logo

Novo Nordisk·Phase 1·NCT06513104·47 enrolled

Efficacy and Safety1 trial

Trauma Acute Pain Treatment With Methoxyflurane Vaporized (PENTHROX®): Efficacy and Safety Study (MEDITA)

Completed·MMundipharma Pharmaceuticals srl·Phase 3·NCT03585374·272 enrolled

CAR1 trial

Consequences of Doing What Should Not be Done in Primary Care

Completed·UUniversidad Miguel Hernandez de Elche··NCT03482232·750,000 enrolled

Hypertensive1 trial

Variability of Sulfotransferase Activity in Humans: an Approach to Improve Predictive Drug Response Part II: Analysis of Interindividual Variation in Hypertensive Patients

Completed·—·Phase 1·NCT06782204·7 enrolled

Asthma1 trial

The Effect of Single Dose Paracetamol on the Lower Airways of Asthmatic and Healthy Children

Unknown status·TTel-Aviv Sourasky Medical Center·N/A·NCT01073748·60 enrolled

Complication1 trial

Preoperative Dose of Co-amoxiclav for Prevention of Postoperative Complications in Dentoalveolar Surgery

Unknown status·TTaibah University·N/A·NCT03844776·135 enrolled

Prevention1 trial

Prevention of Post-Operative Shivering

Completed·—·Phase 1·NCT04682743·120 enrolled

Toxicity1 trial

Paracetamol Toxicity in Septic Patients

Suspended·—·Phase 3·NCT01182974·80 enrolled

Interscalene Brachial Plexus Block1 trial

Ultrasound Guidance for Interscalene Brachial Plexus Block

Completed·UUniversity of Parma·Phase 4·NCT00702416·50 enrolled

Thoracic Paravertebral Block1 trial

Pain Control After Open Radical Nephrectomy: Thoracic Paravertebral Block Versus External Oblique Intercostal Block

Completed·HHacettepe University·N/A·NCT07071012·98 enrolled

Pregnant Women1 trial

Transplacental Transfer of Drugs Used in Pregnant Women

Completed·UUniversity Hospital, Gasthuisberg·N/A·NCT02622802·250 enrolled

Major Trauma1 trial

Pain Multidisciplinar Intervention in Major Trauma Patients

Completed·NNuria Llorach-Perucho··NCT05355441·38 enrolled

Oxidative Stress1 trial

Paracetamol Effect on Oxidative Stress and Renal Function in Severe Malaria

Completed·UUniversity of Oxford·N/A·NCT01641289·62 enrolled

Pain and Discomfort1 trial

Strategy to Cope Pain and Discomfort in Mammography

Unknown status·—·N/A·NCT04381104·632 enrolled

Atrophic Scar1 trial

Simultaneous Versus Sequential Fractional CO2 Laser and Subcision Combination for Post-acne Atrophic Scars: A Split-face Comparative Study.

Completed·HHo Chi Minh City Hospital of Dermato-Venereology·N/A·NCT05688202·34 enrolled

Hypertension1 trial

PAracetamol Treatment in Hypertension: Effect on Blood Pressure (PATH-BP) Study

Completed·UUniversity of Edinburgh·Phase 4·NCT01997112·100 enrolled

Hypothermia1 trial

Paracetamol Hypothermia Children

Completed·—·Phase 4·NCT04608669·60 enrolled

Clinical Trial1 trial

Randomized Clinical Trial With Aminocaproic Acid in the Prevention of Exodontic Bleeding in Anticoagulants Patients

Unknown status·GGrupo de Estudos Multicentricos em Onco-Hematologia·Phase 4·NCT02238288·154 enrolled

Bacterial Meningitis1 trial

Oral Glycerol and High-Dose Rectal Paracetamol to Improve the Prognosis of Childhood Bacterial Meningitis

Completed·KKamuzu University of Health Sciences·Phase 3·NCT00619203·466 enrolled

Breast Cancer1 trial

Ultrasound Guided Pecs Block and Ketamine Infusion for Preventing Chronic Pain in Patients Undergoing Breast Cancer Surgery

Not yet recruiting·—·N/A·NCT07197684·120 enrolled

Total Knee Arthroplasty1 trial

Outcomes Of Perioperative Pregabalin On Total Knee Arthroplasty

Completed·NNational University Hospital, Singapore·Phase 3·NCT02954484·116 enrolled

Neuropathic Pain1 trial

Paracetamol and Neuropathic Pain

Terminated·UUniversity Hospital, Clermont-Ferrand·Phase 2·NCT03559985·43 enrolled

Prospective1 trial

Observational Prospective Study to Evaluate AEs, Risk Factors and Drug Utilization of BUSCAPINA COMPOSITUM N in Adults From Metropolitan Lima

Completed· Boehringer Ingelheim logo

Boehringer Ingelheim··NCT02910167·360 enrolled

Strabismus1 trial

Comparison Between Peribulbar And Sub-tenon Blocks on Oculocardiac Reflex (OCR) During Pediatric Strabismus Surgery

Unknown status·—·N/A·NCT06293586·140 enrolled

Randomized Controlled Trial1 trial

Large-scale Prospective Double-blind Randomized Controlled Trial of Pecs II Block for Breast Surgery

Completed·GGZA Ziekenhuizen Campus Sint-Augustinus·Phase 4·NCT02544282·140 enrolled

Breast Surgery1 trial

Intercostal Nerves Block in the Midaxillary Line Versus Paravertebral Block for no Reconstructive Breast Surgery

Unknown status·PPaula Diéguez García·Phase 4·NCT02018601·120 enrolled

Morphine1 trial

IV Paracetamol vs IV Morphine vs Placebo in Sciatalgia

Unknown status·—·Phase 4·NCT02504996·300 enrolled

Oral1 trial

Oral Pharmacokinetics of Sulfasalazine, Paracetamol, Fexofenadine and Valsartan Using Different Administration Mediums

Completed·UUniversity Medicine Greifswald·Phase 1·NCT03012763·9 enrolled

Postoperative Pain Relief1 trial

Pre-operative Analgesics for Postoperative Pain Relief After Dental Treatment

Completed·HHadassah Medical Organization·Phase 1·NCT02393339·114 enrolled

Myocardial Infarction1 trial

The Effect of Opioids on P2Y12 Receptor Inhibition in Patients With ST-Elevation Myocardial Infarction Who Are Pre-treated With Crushed Ticagrelor

Completed·AA.H. Tavenier·Phase 4·NCT03400267·200 enrolled

Effectiveness1 trial

Cost-effectiveness of Two Painkillers for Treating Pain After Limb Injuries

Completed·—·Phase 2·NCT00528658·782 enrolled

Bariatric Surgery1 trial

Comparisons of iv Ibuprofen and iv Paracetamol During Bariatric Surgery

Completed·IInonu University·Phase 4·NCT02778958·40 enrolled

Cesarean Delivery1 trial

TAP vs QLB in Patients After Cesarean Delivery

Completed·MMedical University of Lublin·Phase 4·NCT03404908·105 enrolled

Cleft Palate1 trial

Suprazygomatic Block in Cleft Palate Surgery in Children

Completed·—·Phase 2·NCT03412474·80 enrolled

Laparoscopic Cholecystectomy1 trial

Intraoperative Lidocaine Infusion vs. Esmolol Infusion for Postoperative Analgesia in Laparoscopic Cholecystectomy

Completed·—·Phase 4·NCT02327923·90 enrolled

Abdominal Aortic Aneurysm1 trial

Epidural Versus Wound Infusion Plus Morphine Bolus in Open Abdominal Aortic Aneurysm Repair

Completed·UUniversity of Genova·Phase 4·NCT02677532·51 enrolled

Infiltration1 trial

Transversus Abdominis Plane Block Versus Wound Infiltration for Postcesarean Analgesia

Completed·MMansoura University·N/A·NCT02691572·80 enrolled

Radiofrequency Ablation1 trial

A Trial of Intravenous Paracetamol vs. Placebo in Patients Receiving Radiofrequency Ablation of the Medial Branch Facet Nerve

Unknown status·SSheba Medical Center·N/A·NCT02539979·50 enrolled

Femur Fracture1 trial

Analgesic Effect of Paracetamol in Patients With Femur Fracture: is Intravenous Better Than Oral?

Completed·FFondazione Policlinico Universitario Agostino Gemelli IRCCS··NCT05025228·170 enrolled

Type 2 Diabetes1 trial

Effect of Liraglutide on Absorption of Paracetamol in Subjects With Type 2 Diabetes

Completed· Novo Nordisk logo

Novo Nordisk·Phase 1·NCT01517555·18 enrolled

Pneumothorax1 trial

Does Non-Steroidal Anti-inflammatory Drugs Decrease the Quality of Pleurodesis After Mechanical Pleural Abrasion/Pleurectomy for Treatment of Pneumothorax?

Recruiting·—·Phase 1/2·NCT06467318·116 enrolled

Insulin Secretion1 trial

Effect of Food Composition on Postprandial Insulin Secretion in Neonatal Diabetes

Completed·RRoyal Devon and Exeter NHS Foundation Trust·N/A·NCT02921906·16 enrolled

Sciatica1 trial

Comparison of Intravenous Ibuprofen and Paracetamol in Patients With Sciatica Presented to the Emergency Department

Unknown status·PPamukkale University·Phase 4·NCT02777320·120 enrolled

Tramadol1 trial

Tramadol vs.Tramadol With Paracetamol

Completed·YYeditepe University Hospital·N/A·NCT03482492·60 enrolled

Pilot Study1 trial

Feasibility of n-of-1 Trials - a Pilot Study

Completed·UUniversity of Bristol·Phase 2·NCT00371696·10 enrolled

Video-Assisted Thoracoscopic Surgery1 trial

Comparison Paravertebral and Serratus Anterior Plane Block in Video-assisted Thoracoscopic Surgery.

Active, not recruiting·HHacettepe University·N/A·NCT07002788·122 enrolled

Retinopathy of Prematurity1 trial

The Efficacy of Paracetamol in Reducing Pain During Ophthalmological Examination for Retinopathy of Prematurity: a Prospective Randomised Trial

Unknown status·—·N/A·NCT01872871·80 enrolled

Third Molar Surgery1 trial

Pre Emptive Analgesics for Pain Relief in Impacted Lower Third Molar Surgery

Completed·MMelaka Manipal Medical College·Phase 4·NCT04769557·60 enrolled

Vaginal Delivery1 trial

Is Paracetamol an Effective Treatment for Chronic Moderate Pain in the Newborn After Operative Vaginal Delivery?

Completed·UUniversity Hospital, Basel, Switzerland·Phase 4·NCT00488540·280 enrolled

Hypotensive Anesthesia1 trial

Effect of Local Anesthesia Versus Induced Hypotensive Anesthesia on Quality of External Dacryocystorhinostomy Operation

Unknown status·MMansoura University·N/A·NCT05241054·64 enrolled

Meningococcal Disease1 trial

Safety and Immunogenicity of an Investigational Pentavalent Meningococcal ABCYW Vaccine Against Meningococcal Disease in Children, Toddlers, and Infants

Active, not recruiting· Sanofi logo

Sanofi·Phase 1/2·NCT06647407·750 enrolled

Adverse Effect1 trial

Mechanisms of N-acetylcysteine Mediated Vascular Adverse Effects

Completed·UUniversity of Edinburgh·N/A·NCT01209455·24 enrolled

Age1 trial

Topical 5% Imiquimod Cream for Vulvar Paget's Disease

Completed·UUniversity Medical Center Nijmegen·Phase 3·NCT02385188·25 enrolled

Brachytherapy1 trial

Paracetamol With or Without Ketoprofen in the Management of Pain for Patients Receiving Brachytherapy (KETOCOL-1304)

Completed·CCentre Oscar Lambret·Phase 2·NCT02439034·68 enrolled

Completed· GSK logo

GSK·Phase 4·NCT01075243·401 enrolled

Unspecified6 trials

ESP vs ESP With PECS

Completed·MMedical University of Lublin·Phase 4·NCT03592485·33 enrolled

Bioequivalence Study of One Tablet of Paracetamol 1000 mg + Codeine 30 mg vs. Two Tablets of Paracetamol 500 mg + Codeine 30 mg

Completed·AAziende Chimiche Riunite Angelini Francesco S.p.A·Phase 1·NCT02902666·46 enrolled

Paracetamol and Glutathion

Completed·UUniversity Hospital, Clermont-Ferrand·Phase 1·NCT01116596·18 enrolled

Show 3 more trials

Different Peribulbar Blocks With SPI-guided Anaesthesia for VRS (P&MSPIVRS)

Completed·MMedical University of Silesia·N/A·NCT03413371·184 enrolled

Antipyretic Therapy With and Without Cold Sponging

Not yet recruiting·MMuhammad Aamir Latif·N/A·NCT07426744·210 enrolled

A Study Investigating the Pharmacokinetic Profiles of Four Extended Release Paracetamol Formulations

Completed· GSK logo

GSK·Phase 1·NCT01568749·14 enrolled

Sources

References

[1]
ClinicalTrials.gov — 335 trial records for Paracetamol. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — Paracetamol compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for Paracetamol. EMBL-EBI & Wellcome Sanger Institute.
[4]
SEC EDGAR — GSK company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[2]
Highest Phase: Phase 3[1]
Company: GSK