Paracetamol

ApprovedSmall molecule

GSK

Paracetamol is one of 1026 small molecule programs targeting Coronary Artery Disease. It is currently in Approved.

Indications

322

Total Trials

Active Trials

1,025

Competitors

Pipeline

Status by Indication[3][1]

Indication

Coronary Artery DiseaseActive, not recruiting

Cleft PalateActive, not recruiting

PneumothoraxActive, not recruiting

Respiratory Tract InfectionActive, not recruiting

Neuropathic PainActive, not recruiting

Low Back PainActive, not recruiting

Rib FractureActive, not recruiting

Common ColdActive, not recruiting

ToxicityActive, not recruiting

Hip FractureActive, not recruiting

Coronary Artery DiseaseApproved

Active, not recruiting

Cleft PalatePhase 2

Active, not recruiting

PneumothoraxPhase 1/Phase 2

Active, not recruiting

Respiratory Tract InfectionApproved

Active, not recruiting

Neuropathic PainPhase 2

Active, not recruiting

Low Back PainPreclinical

Active, not recruiting

Rib FracturePreclinical

Active, not recruiting

Common ColdApproved

Active, not recruiting

ToxicityPhase 3

Active, not recruiting

Hip FracturePhase 2

Active, not recruiting

Showing 10 of 51 indications

Competition

Competitive Landscape

2828 competitors in Breast Cancer

#DrugCompanyPhaseTrials

Paracetamol

GSK

Approved

1 2

Trodelvy

Gilead

Preclinical

37 3

Tecentriq

Roche

Preclinical

36 4

DATROWAY

Daiichi Sankyo

Preclinical

4 5

MS Contin

Merck & Co.

Preclinical

2 6

Effexor

WWyeth-Lederle Vaccines

Preclinical

2 7

Recentin

NNational Cancer Institute (NCI)

Preclinical

2 8

Zinecard

CChildren's Oncology Group

Preclinical

2 9

Avastin

Roche

Preclinical

4 10

Apatinib Mesylate

BBukwang Pharmaceutical

Preclinical

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q3 2026

N/ANot yet recruiting

Study completion

NCT07426744

N/ARecruiting

Hemodynamic

NCT07466108

Phase 3Recruiting

Dexmedetomidine

NCT06274333

Post-ApprovalRecruiting

Analgesic Efficacy

NCT07440069

Q4 2026

Recruiting

Bariatric Surgery

NCT03538457

N/ANot yet recruiting

Postoperative Analgesia

NCT07463482

Clinical

Trials by Indication[1]

Headache8 trials

Effects of Preemptive Paracetamol and Ibuprofen on Headache and Myalgia in Patients After Electroconvulsive Therapy

Completed·IInonu University·N/A·NCT03783312·60 enrolled

Intravenous Paracetamol, Dexketoprofen and Ibuprofen in the Treatment of Acute Migraine Attack Headache

Unknown status·PPamukkale University·Phase 4·NCT04372264·210 enrolled

Comparison of Drugs on Headache Treatment After ECT Treatment

Unknown status·MMustafa Kemal University·Phase 4·NCT03830398·225 enrolled

Show 5 more trials

Sphenopalatine Ganglion Block for Management of Post- Dural Puncture Headache in Obstetric Patients

Completed·—·N/A·NCT04793490·40 enrolled

Assessment of Oral Caffeine Intake in Changing the Severity of Acute Migraine Attack Using VAS Score Among Patients Attending Headache and Neurology Outpatients Clinic of Ainshams University Hospitals

Recruiting·—·Phase 4·NCT07022496·120 enrolled

Different Approaches for the Management of Post-dural Puncture Headache

Completed·BBahaa Mohammed Refaie·N/A·NCT05253014·120 enrolled

Clinical Study to Evaluate Efficacy of New Paracetamol Formulation Compared to Ibuprofen in Headache

Terminated· GSK logo

GSK·Phase 3·NCT01842633·365 enrolled

Paracetamol With Caffeine to Treat Episodic Tension Type Headache

Terminated· GSK logo

GSK·Phase 2/3·NCT01755702·66 enrolled

Intravenous7 trials

Preemptive Analgesia Using Intravenous Paracetamol

Completed·—·N/A·NCT02884921·87 enrolled

Efficacy of Intravenous (IV) Paracetamol for Treatment of Acute Pain

Completed·TTehran University of Medical Sciences·Phase 4·NCT01465984·60 enrolled

Intravenous Infusion of Paracetamol for Intrapartum Analgesia of Labor

Completed·—·Phase 3·NCT01428375·120 enrolled

Show 4 more trials

Disposition of Intravenous Paracetamol in Young Women

Completed·UUniversitaire Ziekenhuizen KU Leuven··NCT02590900·69 enrolled

Intravenous Paracetamol Versus Intramuscular Tramadol in Shortening the Duration of Labour.

Completed·FFederal Teaching Hospital Abakaliki·N/A·NCT07394491·189 enrolled

Pharmacokinetics, -Dynamics and Safety of Intravenous Paracetamol in Neonates

Completed·UUniversitaire Ziekenhuizen KU Leuven·Phase 2/3·NCT00969176·60 enrolled

Comparison of the Efficacy of Intravenous Dexketoprofen and Paracetamol in the Treatment of Sore Throat

Completed·PPamukkale University·Phase 4·NCT03768882·200 enrolled

Analgesic Efficacy6 trials

Analgesic Efficacy of Morphine Alone or Combined With Paracetamol and/or Ibuprofen for Long-bones Fractures in Children

Completed·AAssistance Publique - Hôpitaux de Paris·Phase 3·NCT02477007·304 enrolled

Post-operative Dental Pain Study Comparing Analgesic Efficacy

Completed· GSK logo

GSK·Phase 4·NCT01082081·300 enrolled

Post-operative Dental Pain Study Comparing Two Different Dosage of Analgesic Efficacy

Completed· GSK logo

GSK·Phase 4·NCT01075243·401 enrolled

Show 3 more trials

Analgesic Efficacy, Safety and Tolerability of Two Paracetamol-Containing Solutions in Post-Surgical Hip Replacement Pain

Completed·BBaxter Healthcare Corporation·Phase 3·NCT00508495·148 enrolled

Analgesic Efficacy and Obstetric Effects of Tramadol, Paracetamol and Placebo in Active Labor

Recruiting·UUniversidad Nacional Autonoma de Honduras·Phase 4·NCT07440069·300 enrolled

Analgesic Efficacy, Safety and Tolerability of Two Paracetamol-containing Solutions in Post-Surgical Dental Pain

Completed·BBaxter Healthcare Corporation·Phase 3·NCT00406679·135 enrolled

Low back pain5 trials

Comparison of Intravenous Ibuprofen and Paracetamol in Patients With Low Back Pain Presented to the Emergency Department

Unknown status·PPamukkale University·Phase 4·NCT02836509·200 enrolled

IV Paracetamol, Dexketoprofen or Morphine for the Treatment of Low Back Pain

Completed·PPamukkale University·Phase 4·NCT01422291·120 enrolled

Magnesium Oral Supplementation for Acute Non-specific Low Back Pain

Completed·IIstanbul University·N/A·NCT04626063·240 enrolled

Show 2 more trials

Paracetamol, Dexketoprofen and Ibuprofen In Non-Traumatic Acute Low Back Pain

Completed·PPamukkale University·Phase 4·NCT04609254·210 enrolled

Evaluation of the Pain Relief Effect of Battlefield Acupuncture on Patients With Chronic Low Back Pain Due to Lumbar Spine Degeneration.

Completed·UUniversity of Medicine and Pharmacy at Ho Chi Minh City·N/A·NCT06874959·60 enrolled

Postoperative Analgesia5 trials

Postoperative Analgesia After Minithoracotomy

Completed·MMedical University of Lublin·Phase 4·NCT03415555·19 enrolled

Non-opioid Analgesic Combination With Morphine for Postoperative Analgesia.

Terminated·RRennes University Hospital·Phase 4·NCT01882530·223 enrolled

A PhaseⅡ/ Ⅲ Seamless Study to Evaluate Efficacy and Safety of Paracetamol Injection as Adjuvant to Morphine-based Postoperative Analgesia

Completed·JJiangsu HengRui Medicine Co., Ltd.·Phase 2/3·NCT02811991·348 enrolled

Show 2 more trials

Preoperative High-Dose Oral Paracetamol for Postoperative Analgesia in Children Undergoing Tonsillectomy"

Not yet recruiting·TThammasat University·N/A·NCT07463482·54 enrolled

Controlled-Release Oxycodone For Postoperative Analgesia After Video-Assisted Thoracic Surgery

Terminated·UUniversity of Parma·Phase 4·NCT00681174·22 enrolled

109 more indications

Common Cold5 trials

Evaluation of the Efficacy and Safety of Two Ibuprofen Combination Products for the Treatment of the Common Cold and Flu in Latin America

Withdrawn· Pfizer logo

Pfizer·Phase 3·NCT01938144

Effects of a Common Cold Treatment on Cognitive Function

Completed· GSK logo

GSK·Phase 4·NCT01466348·72 enrolled

Effect of Paracetamol on the Common Cold

Completed· GSK logo

GSK·Phase 2·NCT01277081·200 enrolled

Show 2 more trials

Placebo and Active Controlled Study to Compare the Efficacy of Aspirin and Paracetamol in Treatment of Sore Throat Associated With a Common Cold

Completed· Bayer logo

Bayer·Phase 4·NCT01465009·508 enrolled

Effects of Two Doses of a Common Cold Treatment on Alertness

Completed· GSK logo

GSK·Phase 3·NCT01686646·240 enrolled

Patent ductus arteriosus4 trials

Paracetamol Versus Ibuprofen in Premature Infants With Hemodynamically Significant Patent Ductus Arteriosus

Completed·MMáximo Vento Torres·Phase 3·NCT04037514·133 enrolled

Paracetamol and Patent Ductus Arteriosus (PDA)

Unknown status·SShaare Zedek Medical Center·Phase 2·NCT01291654·80 enrolled

Paracetamol And Ibuprofen/Indomethacin in Closing Patent Ductus Arteriosus

Terminated·UUniversity of Oulu·Phase 1·NCT03648437·22 enrolled

Show 1 more trial

Platelet Transfusion for Treatment of Patent Ductus Arteriosus in Thrombocytopenic Preterm Neonates

Completed·PPost Graduate Institute of Medical Education and Research, Chandigarh·Phase 3·NCT03022253·44 enrolled

Pain Management4 trials

NSAIDs Versus Paracetamol Versus Paracetamol + NSAIDs in Traumatic Pain Management

Completed·UUniversity of Monastir·Phase 3·NCT03222518·1,500 enrolled

Efficacy Study of Different Analgesic Options in Kidney Stone Pain Management

Completed·HHamad Medical Corporation·Phase 4·NCT02187614·1,645 enrolled

Efficacy of Oral Paracetamol Compared With Oral Ketoprofen for Pain Management in Office Hysteroscopy

Completed·IIndonesia University·Phase 4·NCT07315698·60 enrolled

Show 1 more trial

Vaginal Postpartum Pain Management Protocol Comparison

Completed·RRambam Health Care Campus·N/A·NCT04087317·200 enrolled

Analgesia4 trials

Paracetamol for Intrapartum Analgesia

Unknown status·—·Phase 2·NCT02578251·104 enrolled

Effect of Common Analgesia on Pulp Sensibility

Completed·HHITEC-Institute of Medical Sciences·N/A·NCT07125911·122 enrolled

Comparison of Post-Operative Analgesia After Percutaneous Nephrolithotomy.

Completed·—·Phase 4·NCT04835116·68 enrolled

Show 1 more trial

Efficacy of Paracetamol in Addition to Morphine to Improve Analgesia in the Emergency Department

Completed·BBruno Minotti·Phase 4·NCT03843281·222 enrolled

Ibuprofen4 trials

Paracetamol Versus Ibuprofen for PDA Closure

Unknown status·—·Phase 4·NCT03265782·30 enrolled

PAIR (Paracetamol and Ibuprofen Research) Pilot Trial

Unknown status·MManchester University NHS Foundation Trust·Phase 2/3·NCT04986839·32 enrolled

Effect of Ibuprofen, Paracetamol and Their Combination on Radical Oxygen Species (ROS) Production

Completed·UUllevaal University Hospital·Phase 4·NCT00921505·7 enrolled

Show 1 more trial

Population Pharmacokinetics and Dosage Individualization of Paracetamol and Ibuprofen in Children With PDA

Unknown status·SShandong University··NCT04397913·500 enrolled

Treatment3 trials

Effects Of Native Collagen Type 2 Treatment

Completed·EEskisehir Osmangazi University·N/A·NCT02237989·39 enrolled

Paracetamol Treatment of the Borderline Significant PDA

Unknown status·SShaare Zedek Medical Center·Phase 2·NCT02819414·80 enrolled

Prophylactic Antipyretic Treatment in Children Receiving Pneumococcal Conjugate and Standard Infant Vaccines

Completed· GSK logo

GSK·Phase 3·NCT00370318·400 enrolled

Dysmenorrhea3 trials

IV Paracetamol Versus IV Dexketoprofen in Dysmenorrhea

Unknown status·—·Phase 4·NCT02373514·100 enrolled

Intravenous Tramadol Versus Intravenous Paracetamol in Patients With Dysmenorrhea

Completed·—·Phase 4·NCT03509740·100 enrolled

Comparison of Dexketoprofen, Paracetamol and Ibuprofen in the Treatment of Primary Dysmenorrhea

Unknown status·PPamukkale University·N/A·NCT03697746·300 enrolled

Acetaminophen3 trials

Paracetamol (Acetaminophen) for Closure of PDA in Preterm Infants

Completed·HHillel Yaffe Medical Center·Phase 3·NCT01755728·19 enrolled

Comparison Between Rectal Suppository Acetaminophen and Diclofenac Sodium as Analgesia for Postpartum Perineal Tear

Completed·—·Phase 2·NCT03041779·909 enrolled

Analgesic Effect of Ibuprofen, Paracetamol (Acetaminophen), and Paracetamol (Acetaminophen) Plus Codeine on Acute Pain

Completed·UUllevaal University Hospital·Phase 4·NCT00699114·350 enrolled

Analgesic3 trials

Mental Effects of Analgesic Drugs: Paracetamol and Ibuprofen

Unknown status·—·Phase 1·NCT04424420·150 enrolled

Analgesic Effect of a New Analgesic Based Gel(Douloff) Versus Oral Paracetamol in Acute Soft Injuries

Unknown status·UUniversity of Monastir·Phase 1·NCT05647681·1,100 enrolled

Visualisation of the Central Analgesic Effect of Paracetamol in Functional MRI

Completed·UUniversity Hospital, Clermont-Ferrand·Phase 1·NCT01562704·21 enrolled

Post Operative Pain3 trials

Efficacy of Intravenous Ibuprofen and Paracetamol on Postoperative Pain and Tramadol Consumption in Shoulder Surgery

Completed·—·N/A·NCT05401916·2 enrolled

Codeine Plus Paracetamol Versus Placebo for PRK Post-operative Pain

Completed·UUniversity of Sao Paulo General Hospital·Phase 3·NCT02625753·40 enrolled

Effectiveness of Pre-emptive Analgesics on Post-Operative Pain After Stainless Steel Crown Placement On Primary Molars

Completed·—·Phase 4·NCT05602064·66 enrolled

Dexmedetomidine3 trials

Lidocaine, Paracetamol, and Dexmedetomidine for Rocuronium Injection Pain

Not yet recruiting·—·Phase 4·NCT07169227·170 enrolled

Intranasal Dexmedetomidine Versus Oral Paracetamol as a Pre-anaesthetic Medication in Pediatric Age Group

Completed·—·Phase 2·NCT04949477·86 enrolled

Adding Dexmedetomidine or Tramadol to Paracetamol- An Effort to Attenuate Catheter Related Bladder Discomfort

Recruiting·—·Phase 3·NCT06274333·60 enrolled

Interaction2 trials

A Pharmacokinetic Drug Interaction and Tolerance Study of Paracetamol and Nefopam

Completed·UUniversity Hospital, Clermont-Ferrand·Phase 1·NCT02174068·12 enrolled

The Median Effective Dose (ED50) of Paracetamol and Morphine : A Study of Interaction Study

Completed·PProcare Riaya Hospital·N/A·NCT01366313·90 enrolled

Gastrointestinal2 trials

Gastrointestinal Nutrient Transit and Enteroendocrine Function After Upper Gastrointestinal Surgery

Completed·SSt. James's Hospital, Ireland··NCT03734627·40 enrolled

Gastrointestinal Safety Evaluation of Two Over the Counter Analgesics

Completed· GSK logo

GSK·Phase 4·NCT01822665·28 enrolled

Ketorolac2 trials

Paracetamol Compared With Ketorolac for Post-operative Analgetic

Completed·IIndonesia University·Phase 4·NCT05523102·85 enrolled

Adjuncts to IVRA, a Comparison Between Ketorolac and Paracetamol

Completed·—·Phase 3·NCT03485625·60 enrolled

Pain2 trials

Pain Relief After Corneal Collagen Cross-Linking

Unknown status·—·Phase 1·NCT06212830·51 enrolled

Pain and Suction Curettage

Completed·GGökhan Açmaz·N/A·NCT01947205·111 enrolled

Tonsillectomy2 trials

Effect of Steroids on Post-tonsillectomy Morbidities

Completed·KKing Fahd General Hospital·Phase 2·NCT02401529·100 enrolled

Preemptive Dexamethasone , Paracetamol on Postoperative Period Following Adeno-tonsillectomy in Pediatric .

Completed·—·Phase 2·NCT05143762·90 enrolled

Concentration2 trials

Detection of Paracetamol Concentration in Blood-, Saline- and Urine Samples - a Validation Study for a Novel Technique

Completed·JJohanna Kujala·N/A·NCT04690673·12 enrolled

At What Time Therapeutic Plasma Concentrations of Paracetamol Are Achieved in Two Marketed Formulations

Completed· GSK logo

GSK·Phase 1·NCT01551836·12 enrolled

Respiratory tract infection2 trials

Comparison of the Efficacy of Intravenous Paracetamol and Ibuprofen in the Treatment of Fever Due to Upper Respiratory Tract Infection

Completed·PPamukkale University·Phase 4·NCT03918135·200 enrolled

Placebo and Active Controlled Study to Compare the Antipyretic Efficacy of Aspirin® in Patients With Acute Febrile Upper Respiratory Tract Infections Suspected to be of Viral Origin

Completed· Bayer logo

Bayer·Phase 4·NCT01464944·392 enrolled

Total Hip Arthroplasty2 trials

Effect of Combinations of Paracetamol, Ibuprofen, and Dexamethasone on Patient-Controlled Morphine Consumption in the First 24 Hours After Total Hip Arthroplasty

Completed·NNaestved Hospital·Phase 4·NCT04123873·1,060 enrolled

Study to Evaluate The Analgesic Efficacy and Safety of Intravenous Paracetamol in Subjects With Postoperative Pain After Total Hip Arthroplasty

Completed· Bristol-Myers Squibb logo

Bristol-Myers Squibb·Phase 4·NCT00344045·86 enrolled

Total Knee Arthroplasty2 trials

Outcomes Of Perioperative Pregabalin On Total Knee Arthroplasty

Completed·NNational University Hospital, Singapore·Phase 3·NCT02954484·116 enrolled

Effect of Paracetamol and Ibuprofen Reducing Morphine Requirements After Total Knee Arthroplasty

Completed·IIndonesia University·Phase 2/3·NCT04414995·36 enrolled

Malaria2 trials

Effect of Paracetamol on Renal Function in Plasmodium Knowlesi Malaria

Completed·MMenzies School of Health Research·Phase 3·NCT03056391·360 enrolled

Antimalaria Drugs Susceptibility Testing for an Effective Management of Infected Patients in Sub-Sahara Africa

Completed·—·Phase 3·NCT02974348·300 enrolled

Breast Surgery2 trials

Intercostal Nerves Block in the Midaxillary Line Versus Paravertebral Block for no Reconstructive Breast Surgery

Unknown status·PPaula Diéguez García·Phase 4·NCT02018601·120 enrolled

ESP in Breast Surgery Due to Cancer

Completed·MMedical University of Lublin·Phase 4·NCT04726878·75 enrolled

Acute Postoperative Pain2 trials

Oral Use of Dexketoprofen/Tramadol for Acute Postoperative Pain in Total Hip Replacement With a Direct Anterior Approach.

Completed·KKAT General Hospital·Phase 2·NCT04178109·226 enrolled

Comparison of the Effectiveness of Preemptive Paracetamol and Ibuprofen in Acute Postoperative Pain

Unknown status·—·Phase 4·NCT03063658·108 enrolled

Cesarean Section2 trials

Regional Analgesia After Cesarean Section

Completed·MMedical University of Lublin·Phase 4·NCT03244540·105 enrolled

Preemptive Analgesia With Intravenous Paracetamol for Post-cesarean Section Pain Control

Completed·—·Phase 4·NCT02369133·60 enrolled

Adverse Effect2 trials

Mechanisms of N-acetylcysteine Mediated Vascular Adverse Effects

Completed·UUniversity of Edinburgh·N/A·NCT01209455·24 enrolled

Combined Intravenous Tramadol and Paracetamol Versus Intramuscular Pethidine for Pain Relief During the First Stage of Labor. Compare the Efficacy and Adverse Effects

Recruiting·ZZohar Nachum·N/A·NCT07264309·140 enrolled

Experimental2 trials

A Pharmacokinetic Study Investigating the Rate and Extent of Paracetamol Absorption of Three Experimental Sustained Release Pediatric Suspensions

Completed· GSK logo

GSK·Phase 1·NCT01476215·18 enrolled

A Pharmacokinetic Study of an Experimental Paracetamol Formulation

Completed· GSK logo

GSK·Phase 1·NCT01476176·30 enrolled

Osteoarthritis2 trials

Structured Non-operative Treatment of Knee Osteoarthritis

Completed·NNorthern Orthopaedic Division, Denmark·N/A·NCT01535001·100 enrolled

A 12-Week Efficacy Study of Paracetamol 1000mg Sustained-release Tablets in Patients With Osteoarthritis

Completed· GSK logo

GSK·Phase 3·NCT02311881·960 enrolled

After Cardiac Surgery2 trials

Morphine IV vs Paracetamol IV in Neonates and Infants After Cardiac Surgery

Completed·EErasmus Medical Center·N/A·NCT05853263·208 enrolled

Multimodal Analgesic Treatment Versus Traditional Morphine Analgesia After Cardiac Surgery

Completed·RRigshospitalet, Denmark·Phase 4·NCT01966172·180 enrolled

Opioid Consumption2 trials

The Effect of Intraoperative Ketamine on Opioid Consumption and Pain After Spine Surgery in Opioid-dependent Patients

Completed·RRigshospitalet, Denmark·Phase 4·NCT02085577·147 enrolled

Effect of Early Pain Management at Triage on Opioid Consumption

Completed·UUniversity of Monastir·N/A·NCT03243006·1,500 enrolled

Multiple Sclerosis2 trials

Non-inferiority Study of Ocrelizumab and Rituximab in Active Multiple Sclerosis

Active, not recruiting·RRigshospitalet, Denmark·Phase 3·NCT04688788·600 enrolled

A Study to Characterize Subcutaneous or Intravenous Alemtuzumab in Patients With Progressive Multiple Sclerosis

Completed· Sanofi logo

Sanofi·Phase 1·NCT02583594·24 enrolled

Medication2 trials

Paracetamol as Antipyretic and Analgesic Medication

Completed·UUniversity of Athens·Phase 4·NCT01070732·100 enrolled

Study Assessing the Effect of Medications to Prevent Fever on Prevenar 13®

Completed· Pfizer logo

Pfizer·Phase 4·NCT01392378·908 enrolled

Renal Colic2 trials

Comparison of the Analgesic Efficacy of Dexketoprofen Trometamol, Meperidine, and Paracetamol in Renal Colic

Completed·IIsmail Tekin·Phase 4·NCT06558916·90 enrolled

Oral NSAI Versus Paracetamol or Placebo as a Second Line Treatment for Renal Colics

Completed·UUniversity of Monastir·Phase 3·NCT02304783·1,400 enrolled

Influenza1 trial

A Comparison of Solid and Soluble Forms of Cold and Influenza Remedies

Completed· GSK logo

GSK·Phase 4·NCT01332578·25 enrolled

Vascular Function1 trial

Effects of Opioids and NSAIDs on Sympathetic Nervous System and Vascular Function

Recruiting·UUniversity of Zurich·Phase 4·NCT03781544·90 enrolled

Diverticulitis1 trial

Symptomatic Treatment of Acute Uncomplicated Diverticulitis

Completed·HHelsinki University Central Hospital·N/A·NCT02219698·158 enrolled

Thoracoscopic Surgery1 trial

A Study Investigating Pain Following Single-port or Multi-port Video Assisted Thoracoscopic Surgery

Withdrawn·UUniversity Hospitals Bristol and Weston NHS Foundation Trust·N/A·NCT02556970

Emergencies1 trial

Paracetamol Vs Caffeine Vs Codeine in the Management of Post Traumatic Pain in Emergencies

Completed·UUniversity of Monastir·Phase 3·NCT05229965·1,500 enrolled

Spinal Anesthesia1 trial

Prophylactic Paracetamol or Dexamethasone for Post-spinal Anesthesia Shivering

Completed·—·Phase 4·NCT03679065·300 enrolled

Coronary Artery Disease1 trial

Paracetamol and Endothelial Function in Patients With Stable Coronary Artery Disease

Completed·UUniversity of Zurich·Phase 4·NCT00534651·37 enrolled

Humans1 trial

Variability of Sulfotransferase 1A1 Activity in Humans: an Approach to Improve Predictive Drug Response - Part I: Analysis of Intraindividual Variation in Healthy Adults

Completed·—·Phase 1·NCT03182595·36 enrolled

Rib Fracture1 trial

Pain as Indication for Operative Treatment of Traumatic Rib Fractures

Withdrawn·SSahlgrenska University Hospital·N/A·NCT02094807

Temporomandibular Disorder1 trial

Evaluation of the Efficacy of Different Drugs in the Treatment of the Pain in Patients With Temporomandibular Disorder

Completed·YYuzuncu Yil University·Phase 4·NCT05529290·200 enrolled

Tics1 trial

Effect of Paracetamol on Opicapone Pharmacokinetics in Healthy Volunteers

Completed·BBial - Portela C S.A.·Phase 1·NCT02305017·28 enrolled

Menopause1 trial

A Research Study Looking Into the Effect of NNC0519-0130 on Blood Levels of a Birth Control Pill and Emptying of the Stomach in Women After Menopause

Completed· Novo Nordisk logo

Novo Nordisk·Phase 1·NCT06513104·47 enrolled

Clinical Trial1 trial

Randomized Clinical Trial With Aminocaproic Acid in the Prevention of Exodontic Bleeding in Anticoagulants Patients

Unknown status·GGrupo de Estudos Multicentricos em Onco-Hematologia·Phase 4·NCT02238288·154 enrolled

Bacterial Meningitis1 trial

Oral Glycerol and High-Dose Rectal Paracetamol to Improve the Prognosis of Childhood Bacterial Meningitis

Completed·KKamuzu University of Health Sciences·Phase 3·NCT00619203·466 enrolled

MPA1 trial

Comparison Between 2 Techniques for Lumbar-ESPB

Not yet recruiting·—·N/A·NCT07104097·44 enrolled

COVID-191 trial

A Study of a Candidate COVID-19 Vaccine (COV001)

Completed·UUniversity of Oxford·Phase 1/2·NCT04324606·1,077 enrolled

Breast Cancer1 trial

Ultrasound Guided Pecs Block and Ketamine Infusion for Preventing Chronic Pain in Patients Undergoing Breast Cancer Surgery

Not yet recruiting·—·N/A·NCT07197684·120 enrolled

Neuropathic Pain1 trial

Paracetamol and Neuropathic Pain

Terminated·UUniversity Hospital, Clermont-Ferrand·Phase 2·NCT03559985·43 enrolled

Prospective1 trial

Observational Prospective Study to Evaluate AEs, Risk Factors and Drug Utilization of BUSCAPINA COMPOSITUM N in Adults From Metropolitan Lima

Completed· Boehringer Ingelheim logo

Boehringer Ingelheim··NCT02910167·360 enrolled

Dementia1 trial

Pain in Patients With Dementia and Behavioural Disturbances

Completed·UUniversity of Bergen·Phase 2/3·NCT01021696·352 enrolled

Strabismus1 trial

Comparison Between Peribulbar And Sub-tenon Blocks on Oculocardiac Reflex (OCR) During Pediatric Strabismus Surgery

Unknown status·—·N/A·NCT06293586·140 enrolled

Randomized Controlled Trial1 trial

Large-scale Prospective Double-blind Randomized Controlled Trial of Pecs II Block for Breast Surgery

Completed·GGZA Ziekenhuizen Campus Sint-Augustinus·Phase 4·NCT02544282·140 enrolled

Morphine1 trial

IV Paracetamol vs IV Morphine vs Placebo in Sciatalgia

Unknown status·—·Phase 4·NCT02504996·300 enrolled

Pregnant Women1 trial

Transplacental Transfer of Drugs Used in Pregnant Women

Completed·UUniversity Hospital, Gasthuisberg·N/A·NCT02622802·250 enrolled

Vaginal Delivery1 trial

Is Paracetamol an Effective Treatment for Chronic Moderate Pain in the Newborn After Operative Vaginal Delivery?

Completed·UUniversity Hospital, Basel, Switzerland·Phase 4·NCT00488540·280 enrolled

Hypotensive Anesthesia1 trial

Effect of Local Anesthesia Versus Induced Hypotensive Anesthesia on Quality of External Dacryocystorhinostomy Operation

Unknown status·MMansoura University·N/A·NCT05241054·64 enrolled

Meningococcal Disease1 trial

Safety and Immunogenicity of an Investigational Pentavalent Meningococcal ABCYW Vaccine Against Meningococcal Disease in Children, Toddlers, and Infants

Active, not recruiting· Sanofi logo

Sanofi·Phase 1/2·NCT06647407·750 enrolled

Overweight1 trial

A Study of BGM0504 in Overweight or Obese Participants

Completed·BBrightGene Bio-Medical Technology Co., Ltd.·Phase 1·NCT06920056·28 enrolled

Age1 trial

Topical 5% Imiquimod Cream for Vulvar Paget's Disease

Completed·UUniversity Medical Center Nijmegen·Phase 3·NCT02385188·25 enrolled

Metabolism1 trial

Paracetamol Metabolism Research in Postoperative Hepatic Surgery

Completed·UUniversity Hospital, Lille·N/A·NCT03297073·90 enrolled

Hysterectomy1 trial

Elective Total Abdominal Hysterectomy With Preoperative Analgesia Intravenous Paracetamol Versus Placebo

Completed·QQueen Savang Vadhana Memorial Hospital, Thailand·N/A·NCT07368790·40 enrolled

Microcirculation1 trial

Circulating Free Hemoglobin and Microcirculation After Administration of Paracetamol in Febrile Septic Patient

Completed·UUniversità Politecnica delle Marche··NCT02750163·50 enrolled

Blood-Brain Barrier1 trial

Blood-Brain Barrier Penetration of Therapeutic Agents in Human

Completed· Orion Corporation, Orion Pharma logo

Orion Corporation, Orion Pharma·Phase 1·NCT04571996·4 enrolled

Enrolling by invitation·—·Phase 2/3·NCT07067177·28 enrolled

AIN1 trial

A Pharmacokinetic Study to Compare Sustained Release and Standard Paracetamol Formulations.

Completed· GSK logo

GSK·Phase 1·NCT01551797·14 enrolled

Cohort Study1 trial

Panadol Osteo Pharmaceuticals Benefit Scheme (PBS) Claims Cohort Study

Withdrawn· GSK logo

GSK··NCT02262702

Oral1 trial

Pharmacokinetics of a Standard Paracetamol Tablet and Oral Solution After Oral Administration in Chinese Healthy Volunteers

Completed·—·Phase 1·NCT02095704·6 enrolled

Postpartum Period1 trial

Paracetamol / Ibuprofen for Postpartum Pain in the Early Postpartum Period

Completed·TTel-Aviv Sourasky Medical Center·N/A·NCT04653506·107 enrolled

Vaccination1 trial

Primary and Booster Vaccination Study With Pneumococcal Vaccine GSK1024850A and Prophylactic Antipyretic Treatment

Completed· GSK logo

GSK·Phase 4·NCT01235949·850 enrolled

Chronic Knee Pain1 trial

Radiofrequency Neurotomy In Relieving Chronic Knee Pain

Completed·—·N/A·NCT03224637·60 enrolled

Dexamethasone1 trial

SC Versus IV Isatuximab in Combination With Pomalidomide and Dexamethasone in RRMM

Active, not recruiting· Sanofi logo

Sanofi·Phase 3·NCT05405166·531 enrolled

Hemodynamic1 trial

Hemodynamic Effects of Intravenous Paracetamol in Patients Undergoing Emergency Laparotomy

Recruiting·—·N/A·NCT07466108·90 enrolled

Cholecystectomy1 trial

Comparing Intravenous and Oral Paracetamol for Cholecystectomy

Completed·MMelbourne Health·Phase 4·NCT00292214·30 enrolled

Third Molar1 trial

Nefopam/Paracetamol Fixed Dose Combination in Acute Pain After Impacted Third Molar Extraction

Completed·UUnither Pharmaceuticals, France·Phase 3·NCT04622735·321 enrolled

ESS1 trial

Estimation of Paracetamol in Urine to Assess the Diurnal Variation

Completed·—·N/A·NCT03122561·46 enrolled

Infants1 trial

Extremely Low Gestatonal Age Infants' Paracetamol Study

Completed·OOuti Aikio·Phase 1/2·NCT03641209·40 enrolled

CLE1 trial

Paracetamol Study in Patients With Low Muscle Mass

Unknown status·MMette Cathrine Oerngreen·Phase 4·NCT03648658·48 enrolled

Hip Fracture1 trial

Pain Management in Geriatric Hip Fracture

Completed·QQueen Elizabeth Hospital, Hong Kong·Phase 2·NCT01630343·400 enrolled

Sprain1 trial

Approach to Ankle Sprains in the Emergency Department

Completed·—·Phase 4·NCT06563271·150 enrolled

Retinopathy of Prematurity1 trial

Pain Management During Screening for Retinopathy of Prematurity

Completed·IIstanbul Medeniyet University··NCT04767178·44 enrolled

Third Molar Surgery1 trial

Comparative Analgesic Effects of Paracetamol/Codeine and Ibuprofen on Pain After Third Molar Surgery

Completed·UUniversity of Roma La Sapienza·Phase 4·NCT04730297·120 enrolled

Brain Injury1 trial

The Paracetamol AfteR Traumatic Brain InjurY Study

Completed·DDr. M.K. Saxena·Phase 2·NCT01231139·41 enrolled

Abortion1 trial

Postoperative Pain After Medical Abortion Under Local Anesthesia : Comparison of Several Analgesic Regimen

Completed·UUniversity Hospital, Angers·N/A·NCT00188071·240 enrolled

Post Operative Sore Throat1 trial

Combined Effect of Dexamethasone and Paracetamol for Postoperative Sore Throat

Unknown status·SSeoul National University Hospital·N/A·NCT02252419·242 enrolled

Breast1 trial

Breastmilk Alone or in Combination With Paracetamol for Reducing Pain

Unknown status·—·Phase 4·NCT05354479·60 enrolled

Labor Pain1 trial

Oral Paracetamol as Preemptive Analgesia for Labor Pain

Completed·—·Phase 3·NCT01817829·100 enrolled

SARS CoV 2 Infection1 trial

Early Treatment of Vulnerable Individuals With Non-Severe SARS-CoV-2 Infection

Unknown status·AANRS, Emerging Infectious Diseases·Phase 2/3·NCT04920838·600 enrolled

Diffuse Large B-Cell Lymphoma1 trial

A Study on Pharmacokinetics (PK), Efficacy and Safety of Subcutaneous (SC) Versus Intravenous (IV) Rituximab, in Combination With CHOP (Cyclophosphamide, Doxorubicin, Vincristine, Prednisone) in Previously Untreated Participants With CD20 Positive Diffuse Large B-Cell Lymphoma (DLBCL)

Completed· Roche logo

Roche·Phase 2·NCT04660799·50 enrolled

Postoperative Pain Management1 trial

Morphine-sparing Effect of Intravenous Paracetamol for Post-operative Pain Management Following Laparoscopic Gastric Banding in Morbidly Obese Patients

Unknown status·SSoroka University Medical Center·N/A·NCT02154464·220 enrolled

Placebo Effect1 trial

Placebo Effect of Paracetamol in Healthy Volunteers

Completed·UUniversity Hospital, Clermont-Ferrand·Phase 1·NCT01053650·40 enrolled

Infusion1 trial

Management Of The Infusion-Associated Reactions In RRMS Patients Treated With LEMTRADA

Completed· Sanofi logo

Sanofi·Phase 4·NCT02205489·58 enrolled

Long-term Follow-up1 trial

Long-term Follow-up of Lichtenstein's Operation Versus Mesh Plug Repair

Completed·UUniversity Hospital, Basel, Switzerland·N/A·NCT01637818·594 enrolled

Musculoskeletal Pain1 trial

Comparison of Efficacy of Intravenous Paracetamol and Dexketoprofen for Acute Traumatic Musculoskeletal Pain

Completed·PPamukkale University·Phase 4·NCT03428503·200 enrolled

Pacemaker1 trial

PECs Block for Pacemaker Insertion in Children

Completed·KKasr El Aini Hospital·Phase 4·NCT04931693·40 enrolled

General Anesthesia1 trial

Pain Management Following Dental Treatment Under General Anesthesia

Completed·KKing Abdullah University Hospital·N/A·NCT06574516·118 enrolled

Labor Analgesia1 trial

Epidural Tap in Labor Analgesia FOR LABOR ANALGESIA

Completed·MMedipol University·N/A·NCT05499234·70 enrolled

Remifentanil1 trial

Remifentanil Versus Paracetamol for Pain Treatment External Cephalic Versions.

Completed·BBasque Health Service·Phase 3·NCT01048398·60 enrolled

Opioids1 trial

PARASTOP - Paracetamol With Strong Opioids

Completed·OOslo University Hospital·Phase 3·NCT05051735·204 enrolled

Caesarean Section1 trial

Protective Analgesia in Caesarean Section Using Intravenous Paracetamol

Unknown status·—·N/A·NCT03060265·60 enrolled

Gastrectomy1 trial

Pharmacokinetics of Paracetamol and Antiepileptic Drugs After Sleeve Gastrectomy

Terminated·RRambam Health Care Campus·Phase 4·NCT03161509·2 enrolled

Thoracic Paravertebral Block1 trial

Pain Control After Open Radical Nephrectomy: Thoracic Paravertebral Block Versus External Oblique Intercostal Block

Completed·HHacettepe University·N/A·NCT07071012·98 enrolled

Major Trauma1 trial

Pain Multidisciplinar Intervention in Major Trauma Patients

Completed·NNuria Llorach-Perucho··NCT05355441·38 enrolled

Local Anesthetic1 trial

Ibuprofen, Paracetamol Versus Placebo on Pain During Local Anesthetic Injection (RCT)

Unknown status·—·Phase 1/2·NCT03184649·52 enrolled

Unspecified12 trials

Paracetamol and Glutathion

Completed·UUniversity Hospital, Clermont-Ferrand·Phase 1·NCT01116596·18 enrolled

Different Peribulbar Blocks With SPI-guided Anaesthesia for VRS (P&MSPIVRS)

Completed·MMedical University of Silesia·N/A·NCT03413371·184 enrolled

Antipyretic Therapy With and Without Cold Sponging

Not yet recruiting·MMuhammad Aamir Latif·N/A·NCT07426744·210 enrolled

Show 9 more trials

Paracetamol and Metamizole With SPI-guided Anaesthesia for VRS

Completed·MMedical University of Silesia·N/A·NCT03389243·165 enrolled

A Study Investigating the Pharmacokinetic Profiles of Four Extended Release Paracetamol Formulations

Completed· GSK logo

GSK·Phase 1·NCT01568749·14 enrolled

Pharmacokinetic Study of Paracetamol.

Unknown status·KKolding Sygehus·Phase 1·NCT03953287·12 enrolled

Paracetamol and Pharmacogenetic

Completed·UUniversity Hospital, Clermont-Ferrand·Phase 1·NCT01520792·100 enrolled

Pharmacokinetic Study of a Fixed Dose Combination Nefopam Hydrochloride (30 mg) / Paracetamol (500 mg)

Completed·UUnither Pharmaceuticals, France·Phase 1·NCT05129137·32 enrolled

Effect of Parcetamol in Headach

Not yet recruiting·—·Phase 3·NCT06861738·100 enrolled

To Test Bioequivalence Between Two Formulations of Paracetamol/Phenylephrine

Completed·MMcNeil AB·Phase 1·NCT01112462·40 enrolled

Bioequivalence Study of One Tablet of Paracetamol 1000 mg + Codeine 30 mg vs. Two Tablets of Paracetamol 500 mg + Codeine 30 mg

Completed·AAziende Chimiche Riunite Angelini Francesco S.p.A·Phase 1·NCT02902666·46 enrolled

ESP vs ESP With PECS

Completed·MMedical University of Lublin·Phase 4·NCT03592485·33 enrolled

Sources

References

[1]
ClinicalTrials.gov — 322 trial records for Paracetamol. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — Paracetamol compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for Paracetamol. EMBL-EBI & Wellcome Sanger Institute.
[4]
SEC EDGAR — GSK company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[2]
Highest Phase: Approved[1]
Company: GSK

Paracetamol

Status by Indication[3][1]

Competitive Landscape

Expected Milestones

Q3 2026

Q4 2026

Trials by Indication[1]

Headache8 trials

Intravenous7 trials

Analgesic Efficacy6 trials

Low back pain5 trials

Postoperative Analgesia5 trials

Common Cold5 trials

Patent ductus arteriosus4 trials

Pain Management4 trials

Analgesia4 trials

Ibuprofen4 trials

Treatment3 trials

Dysmenorrhea3 trials

Acetaminophen3 trials

Analgesic3 trials

Post Operative Pain3 trials

Dexmedetomidine3 trials

Interaction2 trials

Gastrointestinal2 trials

Ketorolac2 trials

Pain2 trials

Tonsillectomy2 trials

Concentration2 trials

Respiratory tract infection2 trials

Total Hip Arthroplasty2 trials

Total Knee Arthroplasty2 trials

Malaria2 trials

Breast Surgery2 trials

Acute Postoperative Pain2 trials

Cesarean Section2 trials

Adverse Effect2 trials

Experimental2 trials

Osteoarthritis2 trials

After Cardiac Surgery2 trials

Opioid Consumption2 trials

Multiple Sclerosis2 trials

Medication2 trials

Renal Colic2 trials

Influenza1 trial

Vascular Function1 trial

Diverticulitis1 trial

Thoracoscopic Surgery1 trial

Emergencies1 trial

Spinal Anesthesia1 trial

Coronary Artery Disease1 trial

Humans1 trial

Rib Fracture1 trial

Temporomandibular Disorder1 trial

Tics1 trial

Menopause1 trial

Clinical Trial1 trial

Bacterial Meningitis1 trial

MPA1 trial

COVID-191 trial

Breast Cancer1 trial

Neuropathic Pain1 trial

Prospective1 trial

Dementia1 trial

Strabismus1 trial

Randomized Controlled Trial1 trial

Morphine1 trial

Pregnant Women1 trial

Vaginal Delivery1 trial

Hypotensive Anesthesia1 trial

Meningococcal Disease1 trial

Overweight1 trial

Age1 trial

Metabolism1 trial

Hysterectomy1 trial

Microcirculation1 trial

Blood-Brain Barrier1 trial

Bariatric Surgery1 trial

Elective Cardiac Surgery1 trial

Elderly1 trial