VivoSeq
Musculoskeletal

Low Back Pain

204

Pipeline Programs↗

40

Active Trials↗

73

Companies Involved↗

Low back pain is a highly competitive landscape with 204 programs across 73 companies. The most active players are Stayble Therapeutics, Centrexion Therapeutics, Scienture. 59 therapies are approved with 72 more in late-stage development.

Intelligence

Pipeline Metrics

Competitive Density

81/100

Pipeline Velocity

47/100

Mech. Concentration

17/100

Completion Rate

87/100

Attrition Rate

10/100

Competition

Competitive Landscape

Bubble size = clinical trials

Approved
Phase 3
Phase 2
Phase 1
Preclinical

Key Players

Top Companies Companies ranked by the number of pipeline programs they run for this disease.

S

Stayble Therapeutics

1 program

Phase 1C

Centrexion Therapeutics

1 program

Phase 1S

Scienture

1 program

Phase 1COMPASS Pathways logo

COMPASS Pathways

1 program

Phase 1M

Melinta Therapeutics, Inc.

1 program

Phase 1Sun Pharma Advanced Research Company Limited logo

Sun Pharma Advanced Research Company Limited

4 programs

Phase 2

Pipeline

Programs by Phase

Preclinical19

Methylprednisolone

Pfizer

Dexamethasone

Aspen Global Incorporated

Clonidine

Boehringer Ingelheim

Paracetamol

GSK

Magnesium

Spherium Biomed

Phase 110

Morphine Sulfate

Merck & Co.

Naloxone

Scienture

Platelet Rich Plasma

Zagazig University

Psilocybin

COMPASS Pathways

Methylphenidate

Novartis

Phase 244

Gabapentin

Viatris Specialty LLC

Metformin

EMD Serono

Diclophenac Sodium and Thiocolchicoside

Medipol University

Ketamine Hydrochloride

Boehringer Ingelheim

Propranolol

Wyeth-Lederle Vaccines

Phase 372

Onabotulinumtoxina

Vitae Pharmaceuticals Inc., an Allergan affiliate

Etoricoxib

Novartis

Infliximab

Organon and Co

Prednisolone Acetate

Novartis

Tramadol Hydrochloride

Haisco Pharmaceutical Group Co., Ltd.

Approved59

Ketoprofen

Wyeth-Lederle Vaccines

Modafinil

Nuvo Research GmbH

Caffeine

Hikma Pharmaceuticals LLC

Celecoxib

Philadelphia Eye Associates

Tizanidine

Legacy Health System

Analysis

Modality Breakdown

97%

Small molecule

221 of 227 classified programs — the dominant modality here.

3%ALL OTHERSMonoclonal antibody42%Peptide1<1%Cell therapy1<1%

Small molecule leads; the ring shows all 227 classified programs, each share of the total. Modality classified for 100% of 238 pipeline programs.

Analysis

Trial Status

263

clinical trials

Completed174 · 66%
Unknown status22 · 8%
Recruiting21 · 8%
Terminated19 · 7%
Not yet recruiting11 · 4%
Withdrawn8 · 3%
Other8 · 3%

Clinical Trials

Trial Activity

263 trials

Efficacy of Antibiotic Treatment for Patients With Chronic Low Back Pain and Modic Type I Changes - Randomized Placebo-controlled Trial
Recruiting·—·Phase 3·NCT06771492·204 enrolled
Effectiveness of a Multidisciplinary Treatment for Patients With Chronic Low Back Pain
Recruiting·UUniversity of Barcelona·N/A·NCT06679205·62 enrolled
Pulsed RF Neuromodulation and Leukocyte-Rich PRP for Refractory Low Back Pain
Recruiting·IIffat Anwar Medical Complex·Phase 1·NCT06524531·100 enrolled
Prolotherapy in Acupoints in Chronic Non-specific Low Back Pain (cLBP)
Recruiting·NNational and Kapodistrian University of Athens·Phase 1·NCT07296653·60 enrolled
Ketamine-assisted Integrative Treatment for Veterans With Chronic Low Back Pain and Comorbid Depression
Recruiting·VVA Office of Research and Development·Phase 2·NCT06419439·44 enrolled
Evaluation of the Benefit and Safety of Localized Tissue Hydration in the Management of Chronic Low Back Pain
Recruiting·GGCS Ramsay Santé pour l'Enseignement et la Recherche·Phase 2·NCT06471998·29 enrolled
Safety and PK of Intrathecal CNTX-3001 for Intractable Chronic Low Back Pain
Recruiting·CCentrexion Therapeutics·Phase 1·NCT07122453·16 enrolled
A Study of Retatrutide (LY3437943) in Participants Who Have Obesity or Overweight and Chronic Low Back Pain
Recruiting·Eli Lilly logoEli Lilly·Phase 3·NCT07035093·586 enrolled
Sodium Aescinate for the Treatment of Low Back Pain (LBP) in Adults
Recruiting·XXijing Hospital·Phase 1·NCT07339631·40 enrolled
Effectiveness of Thoracolumbar Fascia Mobilization and Ultrasound-Guided 5% Dextrose Injection in Chronic Low Back Pain
Recruiting·—·N/A·NCT07241559·75 enrolled
Psilocybin in Chronic Low Back Pain and Depression
Recruiting·JJohns Hopkins University·Phase 1·NCT06355414·40 enrolled
PRGF-ENDORET® Infiltrations in the Treatment of Low Back Pain.
Recruiting·BBiotechnology Institute IMASD·Phase 4·NCT06715085·48 enrolled
Assessment of Different Clinical Techniques to Treat Patients With Chronic Low Back Pain
Recruiting·IIffat Anwar Medical Complex·N/A·NCT06453291·100 enrolled
Melatonin for Patients With Chronic Low Back Pain
Recruiting·—·Phase 3·NCT06859957·240 enrolled
Effect of Manual Therapy on Low Back Pain in Osteopenic Postmenopausal Women
Recruiting·—·N/A·NCT06671665·40 enrolled
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Data sources: ClinicalTrials.gov (NIH) · OpenFDA (FDA) · ChEMBL (EMBL-EBI) · Open Targets (EBI/Sanger) · MedlinePlus (NIH) · PubMed (NIH) · SEC EDGAR (SEC)