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Musculoskeletal/Low Back Pain

Musculoskeletal

Low Back Pain

31

Pipeline Programs↗

125

Active Trials↗

56

Companies Involved↗

Low back pain is a moderately active landscape with 31 programs across 56 companies. The most active players are Centrexion Therapeutics. 3 programs are in Phase 3.

Intelligence

Pipeline Metrics

Competitive Density

68/100

Pipeline Velocity

87/100

Mech. Concentration

20/100

Completion Rate

88/100

Attrition Rate

7/100

Competition

Competitive Landscape

Bubble size = clinical trials

Approved

Phase 3

Phase 2

Phase 1

Preclinical

Key Players

Top Companies

Centrexion Therapeutics

1 program

Pipeline

Programs by Phase

Preclinical21

Methylprednisolone

Pfizer

Clonidine

Boehringer Ingelheim

Magnesium

Spherium Biomed

Nsaids

Roche

PPP Treatment

Regenexx, LLC

Phase 14

Naloxone

Scienture

CNTX-3001

Centrexion Therapeutics

Sodium Aescinate

Xijing Hospital

Psilocybin

COMPASS Pathways

Phase 23

Ketamine Hydrochloride

Boehringer Ingelheim

Diclofenac /ml

Aksaray University Training and Research Hospital

Psilocybin Therapy With Zolpidem

Joshua Woolley, MD, PhD

Phase 33

Rexlemestrocel-L

Mesoblast, Ltd.

Tolperisone

Neurana Pharmaceuticals, Inc.

Biofreeze

Sport and Spine Rehab Clinical Research Foundation

Approved

No programs

Analysis

Modality Breakdown

96%

Small molecule

26 of 27 classified programs — the dominant modality here.

Small molecule leads; the ring shows all 27 classified programs, each share of the total. Modality classified for 97% of 31 pipeline programs.

Analysis

Trial Status

388

clinical trials

Completed212 · 55%

Recruiting60 · 15%

Not yet recruiting46 · 12%

Unknown status22 · 6%

Terminated19 · 5%

Active, not recruiting14 · 4%

Other15 · 4%

Clinical Trials

Trial Activity

388 trials

The Prognostic Role of Central Sensitization in Short-Term Clinical Outcomes in Chronic Nonspecific Low Back Pain

Recruiting·Mardin Artuklu University·N/A·NCT07826546·180 enrolled

Back to Back: the Forgotten Role of Back Muscle Characteristics to Tailor Exercise Therapy for Recurrent Non-specific Low Back Pain

Recruiting·HHasselt University·N/A·NCT05851196·100 enrolled

Impact of Leisure Activities on Quality of Life in Patients With Chronic Low Back Pain

Recruiting·Centre Hospitalier Valida·N/A·NCT07467499·148 enrolled

Algorithm-informed Decision-making to Advance Pain Treatment (ADAPT Study)

Recruiting·UUniversity of Michigan·Preclinical·NCT07731750·500 enrolled

A Multi-Center Randomized Clinical Study of the NOCISCAN MR Spectroscopy (MRS) in Patients Treated for Discogenic Low Back Pain

Recruiting·AAclarion·N/A·NCT06661850·300 enrolled

Effectiveness of Ultrasound-guided Percutaneous Electrical Stimulation of the Inferior and Superior Gluteal Nerves as Treatment for Gluteus Maximus and Medius Muscle Dysfunction After an Episode of Low Back Pain: Randomized Clinical Trial

Recruiting·—·Preclinical·NCT06873386·24 enrolled

Fusion or Not- a Randomized Controlled Study on Low Back Pain

Recruiting·UUppsala University·Preclinical·NCT06709391·90 enrolled

Study of Correlation Between Serum BDNF Levels and Pfirmann Grading and IL- 1β

Recruiting·KKeimyung University Dongsan Medical Center·N/A·NCT07807839·59 enrolled

Psilocybin and Affective Function in Chronic Lower Back Pain Depression

Recruiting·JJohns Hopkins University·Phase 1·NCT06355414·40 enrolled

Intracept Minimally-invasive PROcedure for VErtebrogenic Back Pain

Recruiting·BBoston Scientific Corporation·N/A·NCT06827262·1,500 enrolled

Comparing the Effects of Yoga Nidra, Yoga, and Control Condition on Thermal Pain Processing, Psychological Factors, and Movement-Evoked Pain in Individuals With Chronic Low Back Pain

Recruiting·University of Central Florida·Preclinical·NCT07543835·27 enrolled

Combined Effects of Post-Isometric Relaxation and Myofascial Release in Patients With Low Back Pain and Lower Cross Syndrome: A Randomized Controlled Trial

Recruiting·UUniversity of Karachi·Preclinical·NCT07496099·60 enrolled

Effects of Whole-Body Vibraton and Pilates on Pain, Dynamic Balance, and Functional Performance in Chronic Non-Specific Low Back Pain

Recruiting·Lahore University of Biological and Applied Sciences·Preclinical·NCT07719699·68 enrolled

Study of Correlation Between the Level of Intradiscal Periostin Expression and Pfirrmann Grading

Recruiting·KKeimyung University Dongsan Medical Center·N/A·NCT07776366·20 enrolled

Telerehabilitation for Patients With Chronic Low Back Pain (TeleBACK Clinical Trial)

Recruiting·JJohns Hopkins University·Preclinical·NCT06821607·1,000 enrolled

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Data sources: ClinicalTrials.gov (NIH) · OpenFDA (FDA) · ChEMBL (EMBL-EBI) · Open Targets (EBI/Sanger) · MedlinePlus (NIH) · PubMed (NIH) · SEC EDGAR (SEC)