Dimenhydrinate

Phase 3Small molecule

SSt. Justine's Hospital

Dimenhydrinate is one of 47 small molecule programs targeting Nausea and vomiting. It is currently in Phase 3.

Indications

Total Trials

Active Trials

Competitors

Pipeline

Status by Indication[3][1]

Indication

Nausea and VomitingActive, not recruiting

VertigoNot yet recruiting

Nausea and VomitingPreclinical

Active, not recruiting

VertigoPhase 3

Not yet recruiting

Competition

Competitive Landscape

78 competitors in Nausea and Vomiting

#DrugCompanyPhaseTrials

Decadron

AAspen Global Incorporated

Approved

62 2

Sufenta

LLeaf Vertical Inc.

Approved

2 3

Atropen

FFresenius Kabi Taiwan Ltd.

Approved

1 4

Xylocaine

MMEDRx USA, Inc.

Approved

1 5

Thalomid

Bristol-Myers Squibb

Phase 3

2 6

Abraxane

Bristol-Myers Squibb

Phase 3

1 7

Gemzar

Johnson & Johnson

Phase 3

1 8

Megace

Bristol-Myers Squibb

Phase 3

1 9

Nereus

VVanda Pharmaceuticals

Phase 3

2 10

Dimenhydrinate

SSt. Justine's Hospital

Phase 3

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q4 2027

PreclinicalNot yet recruiting

Vertigo

NCT07749573

Clinical

Trials by Indication[1]

Nausea and vomiting2 trials

Prophylactic Dimenhydrinate for Intraoperative Nausea and Vomiting

Completed·SSamuel Lunenfeld Research Institute, Mount Sinai Hospital·N/A·NCT00791960·149 enrolled

The Effect of Dimenhydrinate on Postoperative Nausea and Vomiting After Abdominal Hysterectomy: Randomized-controlled Trial

Not yet recruiting·PPreeyaporn Jirakittidul·N/A·NCT06395064·160 enrolled

Vertigo2 trials

Comparison of Efficacy Dimenhydrinate and Metoclopramide in the Treatment of Nausea Due to Vertigo

Completed·PPamukkale University·Phase 4·NCT02253524·200 enrolled

The Effect of Chewing Gum in Addition to Standard Treatment on Dizziness in Patients Diagnosed With Posterior Canal Benign Paroxysmal Positional Vertigo in the Emergency Department: A Randomized Controlled Clinical Trial

Not yet recruiting·AAnkara Ataturk Sanatorium Training and Research Hospital·Preclinical·NCT07749573·88 enrolled

Ondansetron1 trial

Dimenydrinate vs Ondansetron for PONV (DONV)

Completed·UUniversity of Thessaly·N/A·NCT05590936·190 enrolled

Vomiting1 trial

Prevention Post Operative Nausea Vomiting in Ambulatory Gynecologic Laparoscopy

Completed·PPrince of Songkla University·Phase 2·NCT01543945·340 enrolled

Enhanced Recovery1 trial

Recommendations of Enhanced Recovery Interventions for Patient's Clinical Team and Collection of Associated Data

Completed·JJennifer Holder-Murray·Phase 3·NCT04606264·2,977 enrolled

2 more indications

Gastroenteritis1 trial

A Trial Comparing the Effect of Oral Dimenhydrinate Versus Placebo in Children With Gastroenteritis

Completed·SSt. Justine's Hospital·Phase 4·NCT00124787·150 enrolled

Vertigo, Peripheral1 trial

" National, Phase III, Radomized, Double-Blind, Double -Dummy, Controlled, Parallel to Evaluate Non Inferiority of Meclin® (Meclizine Chlorhydrate) Versus Dramin® (Dimenhydrinate) Soft Gel Capsules in the Control of Acute Vertigo Symphtoms From Peripheral Origin"

Completed·AApsen Farmaceutica S.A.·Phase 3·NCT02112578·292 enrolled

Sources

References

[1]
ClinicalTrials.gov — 9 trial records for Dimenhydrinate. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — Dimenhydrinate compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for Dimenhydrinate. EMBL-EBI & Wellcome Sanger Institute.
[4]
SEC EDGAR — St. Justine's Hospital company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[2]
Highest Phase: Phase 3[1]
Company: SSt. Justine's Hospital

Dimenhydrinate

Status by Indication[3][1]

Competitive Landscape

Expected Milestones

Q4 2027

Trials by Indication[1]

Nausea and vomiting2 trials

Vertigo2 trials

Ondansetron1 trial

Vomiting1 trial

Enhanced Recovery1 trial

Gastroenteritis1 trial

Vertigo, Peripheral1 trial

References

Drug Info

Quick Facts

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