Growth hormone

Phase 3Small molecule

Pfizer

Growth hormone is one of 235 small molecule programs targeting Small for gestational age. It is currently in Phase 3.

Indications

Total Trials

Active Trials

234

Competitors

Pipeline

Status by Indication[3][1]

Indication

Small for Gestational AgeActive, not recruiting

Ovarian ReserveActive, not recruiting

ObesityActive, not recruiting

OsteoporosisActive, not recruiting

InteractionCompleted

LocalCompleted

Insulin SensitivityRecruiting

BlastocystRecruiting

Insulin ResistanceNot yet recruiting

GastroparesisRecruiting

Small for Gestational AgePreclinical

Active, not recruiting

Ovarian ReservePreclinical

Active, not recruiting

ObesityPreclinical

Active, not recruiting

OsteoporosisPreclinical

Active, not recruiting

InteractionPreclinical

Completed

LocalPreclinical

Completed

Insulin SensitivityPreclinical

Recruiting

BlastocystPhase 3

Recruiting

Insulin ResistancePhase 1

Not yet recruiting

GastroparesisPhase 1

Recruiting

Showing 10 of 11 indications

Competition

Competitive Landscape

190 competitors in Obesity

#DrugCompanyPhaseTrials

Synthroid

IInstitut Jerome Lejeune

Phase 3

1 2

Vivia

SSpringWorks Therapeutics, Inc., a healthcare company of Merck KGaA, Darmstadt, Germany

Phase 3

1 3

Enavogliflozin

Daewoong Pharmaceutical Co. LTD.

Phase 3

1 4

IBI362

Innovent Biologics (Suzhou) Co. Ltd.

Phase 3

4 5

Growth hormone

Pfizer

Phase 3

1 6

Mibavademab

Regeneron

Phase 3

2 7

Elecoglipron

AstraZeneca

Phase 3

1 8

PF-08653944

Pfizer

Phase 3

5 9

Survodutide

Boehringer Ingelheim

Phase 3

2 10

Aleniglipron

GGasherbrum Bio, Inc., a wholly owned subsidiary of Structure Therapeutics

Phase 3

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q4 2026

Phase 3Recruiting

Blastocyst

NCT05447208

Q3 2027

N/ARecruiting

Injury

NCT05746650

Q4 2027

Phase 1Recruiting

Gastroparesis

NCT06803589

Q2 2028

N/ARecruiting

Insulin Sensitivity

NCT07359625

Post-ApprovalRecruiting

Study completion

NCT05681299

Clinical

Trials by Indication[1]

Growth30 trials

Growth Hormone and Endothelial Function in Children

Completed·OOhio State University·Phase 4·NCT00373386·9 enrolled

Effects of Growth Hormone Administration on Muscle Strength and Body Composition in Men Over 50 Years Old

Completed·UUniversidade Federal do Rio de Janeiro·Phase 4·NCT01853566·13 enrolled

Growth Hormone Treatment of Young Growth Hormone-Deficient Adults

Unknown status·UUniversity Hospital, Angers··NCT00187993·30 enrolled

Show 27 more trials

Growth Hormone for Poor Responders in in Vitro Fertilization (IVF)

Completed·OOttawa Fertility Centre·Phase 2·NCT01204840·38 enrolled

Assessment of the Role of the Growth Hormone (GH) Onthe Intestinal Triglyceride-rich-lipoproteins (TRL) Metabolism

Unknown status·AAssistance Publique Hopitaux De Marseille·Phase 3·NCT01572259·40 enrolled

Effects of Short-term Growth Hormone in HIV-infected Patients

Completed·MMassachusetts General Hospital·N/A·NCT00795210·25 enrolled

Growth Hormone's Effect on Endothelial Progenitor Cells

Completed·VVanderbilt University·N/A·NCT00397592·18 enrolled

Trial of Growth Hormone Therapy in Pediatric Crohn's Disease

Completed·—·Phase 2·NCT00109473·22 enrolled

The Relationship Between Body Composition and Growth Hormone, SIRT Signaling, Protein Turnover and Insulin Sensitivity

Completed·UUniversity of Aarhus·N/A·NCT01299831·19 enrolled

Growth Hormone Adding to Controlled Ovarian Hyperstimulation for Improving Embryo Quality

Unknown status·RReproductive & Genetic Hospital of CITIC-Xiangya·N/A·NCT03966339·128 enrolled

Growth Hormone and Exclusion Diet Therapy in Juvenile Crohn's Disease

Withdrawn·—·Phase 2·NCT01647412

Long Protocol and Growth Hormone in Poor Responders

Completed·WWoman's Health University Hospital, Egypt·Phase 2·NCT02338206·240 enrolled

Growth Hormone's Effect on the Cardiovascular System

Terminated·VVanderbilt University··NCT00397319·26 enrolled

Phase II Randomized Study of the Effects of Growth Hormone on Children and Adolescents on Maintenance Dialysis

Completed·NNational Center for Research Resources (NCRR)·Phase 2·NCT00004340·109 enrolled

Effects of Growth Hormone on Exercise Capacity

Completed·FFederico II University·Phase 3·NCT00501514·22 enrolled

Effect of Growth Hormone on Uterine Receptivity in Women With RIF in an Oocyte Donation Program

Unknown status·CCompetence Centre on Health Technologies·Phase 1·NCT03237117·105 enrolled

Low Dose Growth Hormone (GH) on Insulin Sensitivity and Cortisol Production Rates

Completed·OOregon Health and Science University·Phase 1·NCT00517062·16 enrolled

Treatment of Children With Insufficient Secretion of Growth Hormone

Unknown status·LLG Life Sciences·Phase 3·NCT00271518·144 enrolled

IVF/ICSI Protocols in Poor Responders With Growth Hormone

Completed·WWoman's Health University Hospital, Egypt·Phase 4·NCT01897324·287 enrolled

Growth Hormone Replacement Therapy for Retried Professional Football Players

Recruiting·CCenter for Neurological Studies·Phase 2·NCT04121780·42 enrolled

Growth Hormone Pretreatment in Poseidon Type IV Undergoing ICSI Using Minimal Induction Protocol: A Randomized Controlled Trial

Unknown status·—·N/A·NCT05089344·132 enrolled

Effects of Growth Hormone in Chronically Ill Children

Withdrawn·UUniversity of Texas Southwestern Medical Center·N/A·NCT00286689

Oxandrolone Compared With a Placebo on Growth Rate in Girls With Growth Hormone-Treated Turner's Syndrome

Completed·NNational Institute of Neurological Disorders and Stroke (NINDS)·Phase 2·NCT00004275·80 enrolled

Growth and Metabolic Response to GH and GnRHa Treatment Versus GH Alone in Boys Born SGA.

Completed·RRabin Medical Center·N/A·NCT00522743·17 enrolled

The Effect of Growth Hormone in Assisted Reproductive Technology Clinical Outcome of Poor Responder

Unknown status·SSun Yat-sen University·Phase 4·NCT03027843·80 enrolled

Three-times-weekly Versus Daily Growth Hormone (GH) Treatment in naïve GH-deficient Children

Completed·UUniversity of Palermo·Phase 3·NCT03033121·32 enrolled

Combined Dehydropeiandrosterone and Growth Hormone in Women With Expected Poor Ovarian Response Undergoing ICSI

Unknown status·—·Phase 4·NCT02766764·230 enrolled

Effect of Insulin Sensitization on IGF-1 Response to Growth Hormone in SGA Children

Unknown status·—·N/A·NCT02931591·24 enrolled

Arimidex Multicenter Trial in Growth Hormone (GH) Deficient Boys

Completed·NNemours Children's Clinic·Phase 2/3·NCT00133354·53 enrolled

Randomized Study of Recombinant Human Growth Hormone in Patients on Chronic Hemodialysis or Peritoneal Dialysis

Completed·FFDA Office of Orphan Products Development·N/A·NCT00004429·25 enrolled

Growth Hormone Deficiency6 trials

Growth Hormone Deficiency in Mild Traumatic Brain Injury

Unknown status·UUniversity of Calgary·Phase 1·NCT05660356·20 enrolled

304-C03/L3301n: Effects of Growth Hormone on Glucose and Protein Metabolism in Children With Growth Hormone Deficiency

Unknown status·—·N/A·NCT00362063·20 enrolled

Insulin Sensitivity and Substrate Metabolism Before and After Treatment in Patients With Growth Hormone Deficiency

Completed·UUniversity of Aarhus·N/A·NCT00646815·24 enrolled

Show 3 more trials

Adult Growth Hormone Deficiency and Cardiovascular Risk

Terminated·—·Phase 4·NCT00720902·7 enrolled

Randomized Study of Growth Hormone on Bone Mineral Density in Patients With Adult Onset Growth Hormone Deficiency

Completed·NNational Center for Research Resources (NCRR)·N/A·NCT00006394·72 enrolled

Treatment of Adults With Growth Hormone Deficiency

Completed·LLG Life Sciences·Phase 3·NCT00294619·147 enrolled

Cirrhosis2 trials

Growth Hormone in Decompensated Liver Cirrhosis

Completed·PPost Graduate Institute of Medical Education and Research, Chandigarh·Phase 2/3·NCT05253287·96 enrolled

Growth Hormone Therapy in Liver Cirrhosis

Completed·PPost Graduate Institute of Medical Education and Research, Chandigarh·Phase 2/3·NCT03420144·76 enrolled

Cystic Fibrosis2 trials

Phase II Study of Growth Hormone in Children With Cystic Fibrosis

Completed·UUniversity of Utah·Phase 2·NCT00016445·40 enrolled

Growth Hormone Use in Adolescents and Adults With Cystic Fibrosis

Withdrawn·UUniversity of Texas Southwestern Medical Center·N/A·NCT00287430

Ovarian Reserve2 trials

Growth Hormone to Improve the Clinical Outcome of Assisted Fertility in Young Patients With Decreased Ovarian Reserve

Unknown status·NNanjing University·N/A·NCT05585177·120 enrolled

To Explore the Effect of GH Pretreatment on Clinical Outcomes in Patients With Low Ovarian Reserve

Unknown status·GGuangzhou First People's Hospital··NCT04384783·114 enrolled

36 more indications

GH Deficiency2 trials

Adipose Tissue and Circulating Markers of Inflammation in GH Deficiency and Changes With GH Therapy

Completed·—··NCT03225755·7 enrolled

Adipose Tissue and Serum Inflammation in GH Deficiency

Completed·—··NCT03500913·19 enrolled

Short stature2 trials

Aromatase Inhibitors, Alone And In Combination With Growth Hormone In Adolescent Boys With Idiopathic Short Stature

Completed·NNemours Children's Clinic·Phase 3·NCT01248416·76 enrolled

The Role of Igf-1 Generation Test in Diagnosis and Treatment of Short Stature

Withdrawn·MMaimonides Medical Center·N/A·NCT01970800

Function2 trials

GH in Adults With PWS, Effect on Hypotonia Evaluated by Functional MRI, Relationship With Strength and Body Composition

Completed·CCorporacion Parc Tauli·Phase 4·NCT03616509·30 enrolled

Adipocyte Function and Somtropin Deficiency

Completed· Ferring logo

Ferring··NCT01351818·62 enrolled

Turner syndrome2 trials

Effect of Biosynthetic Growth Hormone and/or Ethinyl Estradiol on Adult Height in Patients With Turner Syndrome

Completed·EEunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)·Phase 2·NCT00001221·160 enrolled

Growth Hormone Treatment of Women With Turner Syndrome

Completed·—·N/A·NCT00420654·24 enrolled

Wound Healing1 trial

Assessment of Mechanisms of Improved Wound Healing

Completed·TThe University of Texas Medical Branch, Galveston·Phase 2/3·NCT00673309·644 enrolled

Alcoholic Fatty Liver Disease1 trial

Growth Hormone and Intrahepatic Lipid Content in Patients With Nonalcoholic Fatty Liver Disease

Completed·MMassachusetts General Hospital·Phase 2·NCT02217345·131 enrolled

Heart Failure1 trial

Treatment of the lOw IGF-1 Syndrome aSsociated With Chronic Heart fAilure: A Randomized, Placebo-Controlled, Double-Blind Study.

Suspended·FFederico II University·Phase 2·NCT01235273·100 enrolled

Cirrhosis of Liver1 trial

Granulocyte Colony Stimulating Factor And Growth Hormone In Cirrhosis Of Liver: An Open Label Study

Completed·PPost Graduate Institute of Medical Education and Research, Chandigarh·Phase 2/3·NCT02451033·65 enrolled

Lip1 trial

Lipolytic Effects of GH in Human Subjects in Vivo

Completed·UUniversity of Aarhus·N/A·NCT02782221·9 enrolled

Small for gestational age1 trial

Retrospective Study Of The Influence Of Age At Start Of Growth Hormone Treatment On Height Gain In Children Born Small for Gestational Age

Completed· Pfizer logo

Pfizer··NCT01897753·264 enrolled

Gastroparesis1 trial

Growth Hormone for the Treatment of Gastroparesis

Recruiting·MMayo Clinic·Phase 1·NCT06803589·10 enrolled

HIV-1 infection1 trial

Novel Interventions in HIV-1 Infection

Terminated·IImperial College London·Phase 1·NCT01130376·12 enrolled

Prader-Willi syndrome1 trial

Is There a Sensibility Increased in the Growth Hormone at Child With Prader-Willi Syndrome?

Completed·UUniversity Hospital, Toulouse·Phase 4·NCT01298180·111 enrolled

Amyotrophic Lateral Sclerosis1 trial

Growth Hormone in Amyotrophic Lateral Sclerosis

Completed·FFederico II University·Phase 2·NCT00635960·40 enrolled

Injury1 trial

Improving Tissue Repair After Injury in the Muscle-tendon Interface Muscle Tissue Injury

Recruiting·—·N/A·NCT05746650·40 enrolled

Phelan-McDermid syndrome1 trial

A Controlled Trial of Growth Hormone in Phelan-McDermid Syndrome and Idiopathic Autism

Completed·IIcahn School of Medicine at Mount Sinai·Phase 2·NCT05187377·32 enrolled

Blastocyst1 trial

Effect of GH on the Blastocyst Euploid Rate in AMA Patients

Recruiting·SShangHai Ji Ai Genetics & IVF Institute·Phase 3·NCT05447208·400 enrolled

Children1 trial

Adrenal Function in GHD Children

Completed·UUniversity of Palermo··NCT03203356·30 enrolled

Obesity1 trial

Study of Growth Hormone and Bone in Obesity

Completed·MMassachusetts General Hospital·N/A·NCT01724489·77 enrolled

COVID-191 trial

Growth Hormone in Obese Cases With Covid-19

Withdrawn·CClinAmygate·Phase 4·NCT04532554

Hypothyroidism1 trial

Growth Hormone and GnRH Agonist in Adolescents With Acquired Hypothyroidism

Terminated·—·Phase 4·NCT00206375·16 enrolled

Short Bowel Syndrome1 trial

Evaluate the Efficacy and Safety Growth Hormone, Glutamine and Diet in Patients With Short Bowel Syndrome (SBS)

Terminated·UUniversity of Nebraska·Phase 4·NCT00742157·5 enrolled

Chronic Myelogenous Leukemia1 trial

Assessment Of Gh-Igf-1 Axis In Children With Chronic Myelogenous Leukemia (CML) In Remission

Unknown status·PPost Graduate Institute of Medical Education and Research, Chandigarh·Phase 4·NCT01901666·20 enrolled

Intracytoplasmic Sperm Injection1 trial

Effect of GH Administration in Poor Responders Undergoing Intracytoplasmic Sperm Injection (ICSI)

Completed·—·Phase 4·NCT05281341·160 enrolled

Outcome1 trial

To Explore the Effect of GH on Outcomes of IVF and Telomerase Activity of Granulosa Cells in Women With POR

Unknown status·GGuangzhou First People's Hospital··NCT04384744·40 enrolled

Insulin Sensitivity1 trial

Effects of Ketone Bodies on Insulin Sensitivity

Recruiting·UUniversity of Aarhus·N/A·NCT07359625·10 enrolled

Insulin resistance1 trial

Human Models of Selective Insulin Resistance: Pancreatic Clamp

Not yet recruiting·—·Phase 1·NCT06558422·36 enrolled

Pancreatic1 trial

Pancreatic Clamp in NAFLD

Completed·—·Phase 1·NCT05724134·18 enrolled

Fatigue1 trial

Growth Hormone or Sildenafil as Therapies for Fatigue in Mild- Traumatic-brain-injury (MTBI)

Completed·TThe University of Texas Medical Branch, Galveston·Phase 1·NCT02114775·34 enrolled

Cohort Study1 trial

Effect of GH Supplementation on the Blastocyst Euploid Rate in AMA Patients--A Retrospective Cohort Study

Completed·SShangHai Ji Ai Genetics & IVF Institute·Phase 3·NCT05574894·692 enrolled

Metabolic Syndrome1 trial

Effect of Growth Hormone in Metabolic Syndrome

Unknown status·—·Phase 4·NCT00307411·32 enrolled

Osteoporosis1 trial

Descriptive Study of Recombinant Human Insulin-Like Growth Factor for Osteoporosis in Werner's Syndrome

Completed·NNational Center for Research Resources (NCRR)·N/A·NCT00004815·1 enrolled

Interaction1 trial

Metabolic Studies- Interactions Between GH and Insulin in GHDA

Completed·UUniversity of Aarhus·N/A·NCT00568568·8 enrolled

Pregnancy1 trial

Low-dose GH Supplementation Increases Clinical Pregnancy Rate

Completed·CCentro de Infertilidad y Reproducción Humana·Phase 1·NCT02359695·64 enrolled

Local1 trial

The Effect of Local Injectet GH on the Collagen Synthesis in the Ligamentum Patella

Completed·UUniversity of Aarhus·N/A·NCT01158612·12 enrolled

Unspecified3 trials

Antagonist Protocol in Poor Responders

Completed·—·Phase 4·NCT02195947·141 enrolled

Microflare Protocol in Poor Responders

Completed·WWoman's Health University Hospital, Egypt·Phase 4·NCT02185326·145 enrolled

Effects of GH and Lirglutide on AgRP

Recruiting·—·Phase 4·NCT05681299·40 enrolled

Sources

References

[1]
ClinicalTrials.gov — 84 trial records for Growth hormone. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — Growth hormone compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for Growth hormone. EMBL-EBI & Wellcome Sanger Institute.
[4]
SEC EDGAR — Pfizer company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[2]
Highest Phase: Phase 3[1]
Company: Pfizer

Growth hormone

Status by Indication[3][1]

Competitive Landscape

Expected Milestones

Q4 2026

Q3 2027

Q4 2027

Q2 2028

Trials by Indication[1]

Growth30 trials

Growth Hormone Deficiency6 trials

Cirrhosis2 trials

Cystic Fibrosis2 trials

Ovarian Reserve2 trials

GH Deficiency2 trials

Short stature2 trials

Function2 trials

Turner syndrome2 trials

Wound Healing1 trial

Alcoholic Fatty Liver Disease1 trial

Heart Failure1 trial

Cirrhosis of Liver1 trial

Lip1 trial

Small for gestational age1 trial

Gastroparesis1 trial

HIV-1 infection1 trial

Prader-Willi syndrome1 trial

Amyotrophic Lateral Sclerosis1 trial

Injury1 trial

Phelan-McDermid syndrome1 trial

Blastocyst1 trial

Children1 trial

Obesity1 trial

COVID-191 trial

Hypothyroidism1 trial

Short Bowel Syndrome1 trial

Chronic Myelogenous Leukemia1 trial

Intracytoplasmic Sperm Injection1 trial

Outcome1 trial

Insulin Sensitivity1 trial

Insulin resistance1 trial

Pancreatic1 trial

Fatigue1 trial

Cohort Study1 trial

Metabolic Syndrome1 trial

Osteoporosis1 trial

Interaction1 trial

Pregnancy1 trial

Local1 trial

Unspecified3 trials

References

Drug Info

Quick Facts

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