human chorionic gonadotropin

ApprovedSmall molecule

Merck & Co.

human chorionic gonadotropin is one of 160 small molecule programs targeting Hypogonadism. It is currently in Approved.

Indications

Total Trials

Active Trials

159

Competitors

Pipeline

Status by Indication[3][1]

Indication

HypogonadismActive, not recruiting

Female InfertilityActive, not recruiting

Hypogonadotropic HypogonadismActive, not recruiting

Polycystic Ovary SyndromeActive, not recruiting

Spinal Cord InjuryActive, not recruiting

InfertilityActive, not recruiting

HypogonadismApproved

Active, not recruiting

Female InfertilityPhase 1/Phase 2

Active, not recruiting

Hypogonadotropic HypogonadismPhase 3

Active, not recruiting

Polycystic Ovary SyndromePreclinical

Active, not recruiting

Spinal Cord InjuryPreclinical

Active, not recruiting

InfertilityPhase 3

Active, not recruiting

Competition

Competitive Landscape

190 competitors in Spinal Cord Injury

#DrugCompanyPhaseTrials

Medrol

Pfizer

Phase 3

3 2

Proamatine

Takeda

Phase 3

2 3

human chorionic gonadotropin

Merck & Co.

Approved

1 4

Minocin

TTriax

Phase 3

2 5

Actonel

VVitae Pharmaceuticals Inc., an Allergan affiliate

Phase 3

2 6

Deltavit

HHyundai Pharmaceutical Co., LTD.

Phase 3

1 7

Cesamet

BBausch Health Americas, Inc.

Phase 3

1 8

Genotropin

Myrbetriq

2 10

Gleevec

Novartis

Phase 2

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q3 2029

Phase 1Not yet recruiting

CLE

NCT06754332

Clinical

Trials by Indication[1]

Hypogonadotropic Hypogonadism5 trials

Efficacy and Safety of Pulsatile Gonadotropin Releasing Hormone Pump Treatment in Patients With Idiopathic Hypogonadotropic Hypogonadism

Unknown status·SShanghai Jiao Tong University School of Medicine·Phase 4·NCT02310074·76 enrolled

A Study Using Recombinant Human Luteinizing Hormone (r-hLH, Luveris®) in the Treatment of Chinese Women With Hypogonadotropic Hypogonadism

Completed· Merck & Co. logo

Merck & Co.·Phase 3·NCT01084265·31 enrolled

Rec-LH PD and Safety Profile in Hypogonadotropic Hypogonadism Men

Unknown status·AAzienda Ospedaliero-Universitaria di Modena·Phase 2·NCT04189133·32 enrolled

Show 2 more trials

Human Menopausal Gonadotropin Combining With Human Chorionic Gonadotropin Treat Congenital Hypogonadotropic Hypogonadism

Unknown status·—·Phase 4·NCT02880280·40 enrolled

Efficacy and Safety of Long Term Use of hCG or hCG Plus hMG in Males With Isolated Hypogonadotropic Hypogonadism (IHH)

Unknown status·TTongji Hospital·Phase 4·NCT03687606·210 enrolled

Polycystic Ovary Syndrome3 trials

Progestin-primed Ovarian Stimulation Protocol Versus GnRH Antagonist Protocol in Polycystic Ovary Syndrome Patients Undergoing IVF/ICSI Cycles

Unknown status·MMansoura University·N/A·NCT05112692·200 enrolled

Effect of GnRH Agonist vs GnRH Antagonist on IVF/ICSI Outcomes in Polycystic Ovary Syndrome Patients.

Completed·—·Phase 4·NCT04727671·50 enrolled

Effect of GnRH Agonist vs GnRH Antagonist on Oocyte Morphology in Polycystic Ovary Syndrome Patients During IVF/ICSI

Completed·—·Phase 4·NCT04727684·50 enrolled

CLE3 trials

Comparative Study Between Single Versus Dual Trigger for Poor Responders in GnRH-antagonist ICSI Cycles

Completed·—·Phase 4·NCT04008966·160 enrolled

The Study of Human Chorionic Gonadotropin (HCG) Activating the Dormant Follicles .

Not yet recruiting·TThe Fourth Affiliated Hospital of Zhejiang University School of Medicine·Phase 1·NCT06754332·60 enrolled

Muscle-Sparing Effect Of Human Chorionic Gonadotropin (hCG) During a Very Low Calorie Diet (VLCD)

Completed·—·Phase 1/2·NCT02427529·59 enrolled

Klinefelter Syndrome2 trials

Sex Steroids Balance for Metabolic and Reproductive Health in Klinefelter Syndrome

Recruiting·GGeorgios Papadakis·Phase 3·NCT05586802·150 enrolled

Human Chorionic Gonadotropin Stimulation Effects on Steroidogenesis in Men With Klinefelter Syndrome

Completed·AAzienda USL Modena·N/A·NCT02788136·25 enrolled

Controlled Ovarian Stimulation2 trials

Supplementation With Human Chorionic Gonadotropin (hCG) During Controlled Ovarian Stimulation With Recombinant Follicle-stimulating Hormone (FSH) for In Vitro Fertilisation

Completed·RRigshospitalet, Denmark·Phase 4·NCT00844311·60 enrolled

An Efficacy and Safety Study of Corifollitropin Alfa (MK-8962) in Contrast to Recombinant FSH for Use in Controlled Ovarian Stimulation of Indian Women (P07056, Also Known as MK-8962-029)

Withdrawn·OOrganon and Co·Phase 3·NCT01599494

25 more indications

Infertility2 trials

Dual FSH/HCG Trigger in Letrozole Stimulated Intrauterine Insemination Cycles in Women With Unexplained Infertility

Completed·—·Phase 3·NCT02739516·108 enrolled

Effect of Endometrial Injury in Couples With Unexplained Infertility

Unknown status·—·N/A·NCT03398993·100 enrolled

GnRH Antagonist2 trials

Effect of GnRH Agonist vs GnRH Antagonist on IVF/ICSI Outcomes.

Completed·—·Phase 4·NCT04724343·50 enrolled

Effect of GnRH Agonist vs GnRH Antagonist on Oocyte Morphology During IVF/ICSI

Completed·—·Phase 4·NCT04724486·50 enrolled

Embryo Transfer2 trials

Intrauterine Injection of Human Chorionic Gonadotropin Before Embryo Transfer in Women With Previous IVF Failure

Unknown status·MMansoura University·Phase 4·NCT02329197·380 enrolled

Frozen-thawed Embryo Transfer in a Natural Cycle: hCG Triggering Versus LH Home Test

Terminated·TTampere University Hospital·Phase 4·NCT03115320·62 enrolled

IVF Outcome1 trial

Effects of Intramural Fibroids on IVF Outcome

Unknown status·—·N/A·NCT03904355·200 enrolled

Body Weight1 trial

The Impact of Body Weight on Reproductive Outcomes in Poor Ovarian Responders in ICSI Cycles

Unknown status·—·N/A·NCT03457233·185 enrolled

Ovarian1 trial

Low Dose GnRHa Early Luteal Phase Down Regulation Versus GnRHa Ultra-short Protocol for Poor Ovarian Response

Unknown status·NNavy General Hospital, Beijing·N/A·NCT02940535·200 enrolled

Homeostasis1 trial

Extragonadal Effects of hCG on Calcium Homeostasis

Completed·MMartin Blomberg Jensen·Phase 1·NCT03418896·12 enrolled

In Vitro Fertilization1 trial

Relationship Between Some Vitamins and Antioxidants With in Vitro Fertilization Outcomes

Completed·—··NCT05393011·60 enrolled

Efficacy and Safety1 trial

Phase 3 Trial to Evaluate the Efficacy and Safety of COL-1620 Vaginal Progesterone Gel

Completed· Merck & Co. logo

Merck & Co.·Phase 3·NCT01863680·178 enrolled

Spinal Cord Injury1 trial

Provocative Testing Using LHRH and hCG of the Pituitary-Gonadal Axis in Persons With Spinal Cord Injury.

Completed·UUS Department of Veterans Affairs·N/A·NCT00223860·100 enrolled

Hypogonadism1 trial

Effects of Medications in Patients With Hypogonadism

Completed·GGulhane School of Medicine·Phase 4·NCT01601327·119 enrolled

Frozen Embryo Transfer1 trial

Replacement of Fresh Embryo Transfers (ETs) by Frozen Embryo Transfers (FETs) Using Vitrification

Unknown status·YYazd Research & Clinical Center for Infertility·Phase 1/2·NCT00823121·500 enrolled

Randomized Controlled Trial1 trial

HUMAN CHORIONIC GONADOTROPIN (HcG) VS MAGNESIUM SULPHATE (MgSo4) AS A TOCOLYTIC AGENT- A RANDOMIZED CONTROLLED TRIAL

Completed·SShaheed Zulfiqar Ali Bhutto Medical University·N/A·NCT05828966·70 enrolled

Female Infertility1 trial

Comparative Study on the Efficacy of Ovarian Stimulation Protocols on the Success Rate of ICSI in Female Infertility

Completed·LLebanese University·Phase 1/2·NCT04071574·200 enrolled

Treatment1 trial

Efficacy of Human Chorionic Gonadotropin in Acute GVHD Treatment

Recruiting·HHospital Universitario Dr. Jose E. Gonzalez·Phase 2·NCT06904599·20 enrolled

Ovulation Induction1 trial

Oxytocin Versus Human Chorionic Gonadotropin as Trigger in Ovulation Induction

Completed·SShakeela Ishrat·Phase 3·NCT06725004·60 enrolled

Phase II1 trial

Prediction of Metaphase II Oocytes According to Different Levels of Serum AMH in Poor Responders Using the Antagonist Protocol

Unknown status·—·N/A·NCT03484611·179 enrolled

Diagnosis1 trial

Preimplantation Genetic Diagnosis (PGD) With Gonadotropin-releasing Hormone (GnRH) Agonist Versus Antagonist

Completed·UUniversitair Ziekenhuis Brussel·Phase 4·NCT01888744·120 enrolled

In Vitro Fertilization (IVF)1 trial

Human Chorionic Gonadotropin (hCG) Priming Prior to Controlled Ovarian Hyperstimulation (COH) in Poor Responder In Vitro Fertilization (IVF) Patients

Completed·IIVI Madrid·Phase 4·NCT00870025·60 enrolled

Progesterone1 trial

Progesterone Levels During Ovulation and Luteal Phase

Completed·AART Fertility Clinics LLC··NCT05076981·6 enrolled

SMA1 trial

Three Small Doses of HCG Versus Booster Dose of HCG on Ovum Pickup Day

Completed·—·Phase 4·NCT02397551·200 enrolled

Outcome1 trial

Effect of Intrauterine Injection of Hcg Before ET on Clinical Outcomes in IVF/ICSI Cycles

Completed·—·N/A·NCT03238807·181 enrolled

Myoma1 trial

The Value of Myomectomy in Women With Intramural Myoma Before IVF.

Unknown status·—·N/A·NCT03904368·100 enrolled

Pregnancy1 trial

Intrauterine Injection of Human Chorionic Gonadotrophin and Pregnancy Rate in ICSI

Completed·—·N/A·NCT03445910·100 enrolled

Unspecified5 trials

Low Dose hCG in the Late Follicular Phase

Completed·UUniversitair Ziekenhuis Brussel·Phase 4·NCT00750100·70 enrolled

Effect of hCG on Receptivity of the Human Endometrium

Completed·MMichigan State University·Phase 4·NCT01786252·15 enrolled

Calciotropic Effects After HCG Stimulation Test

Completed·MMartin Blomberg Jensen··NCT03254641·242 enrolled

Show 2 more trials

Agonist Versus Classical HCG Trigger (Poor Responders, Normoresponders and High Responders)

Unknown status·GGinegorama S.L.·N/A·NCT03307720·300 enrolled

Dual Trigger Versus Booster Dose of HCG

Completed·—·N/A·NCT02397642·200 enrolled

Sources

References

[1]
ClinicalTrials.gov — 47 trial records for human chorionic gonadotropin. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — human chorionic gonadotropin compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for human chorionic gonadotropin. EMBL-EBI & Wellcome Sanger Institute.
[4]
SEC EDGAR — Merck & Co. company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[2]
Highest Phase: Approved[1]
Company: Merck & Co.

human chorionic gonadotropin

Status by Indication[3][1]

Competitive Landscape

Expected Milestones

Q3 2029

Trials by Indication[1]

Hypogonadotropic Hypogonadism5 trials

Polycystic Ovary Syndrome3 trials

CLE3 trials

Klinefelter Syndrome2 trials

Controlled Ovarian Stimulation2 trials

Infertility2 trials

GnRH Antagonist2 trials

Embryo Transfer2 trials

IVF Outcome1 trial

Body Weight1 trial

Ovarian1 trial

Homeostasis1 trial

In Vitro Fertilization1 trial

Efficacy and Safety1 trial

Spinal Cord Injury1 trial

Hypogonadism1 trial

Frozen Embryo Transfer1 trial

Randomized Controlled Trial1 trial

Female Infertility1 trial

Treatment1 trial

Ovulation Induction1 trial

Phase II1 trial

Diagnosis1 trial

In Vitro Fertilization (IVF)1 trial

Progesterone1 trial

SMA1 trial

Outcome1 trial

Myoma1 trial

Pregnancy1 trial

Unspecified5 trials

References

Drug Info

Quick Facts

Related News