Lyrica

(Pregabalin)

ApprovedSmall molecule

PPfizer's Upjohn has merged with Mylan to form Viatris Inc.

Pregabalin is used to treat nerve pain from diabetes or shingles, and it also helps reduce seizures and anxiety. It works by calming overactive nerves in the body that cause pain and other symptoms.[2] Lyrica is currently approved and in use across 74 indications[4].[1]

Lyrica is one of 853 small molecule programs targeting Pruritus. It is currently in Approved.

Indications

421

Total Trials

Active Trials

852

Competitors

FDA Applications

NDA/BLA/ANDA regulatory filings

Patents

Pipeline

Status by Indication[4][1]

Indication

HysterectomyTerminated

Peripheral NeuropathyCompleted

SeizureTerminated

Chronic Pelvic PainNot yet recruiting

FibromyalgiaCompleted

Bilateral Tonic-Clonic SeizureApproved

Intervertebral Disk DegenerationApproved

Opioid DependenceApproved

RadiculopathyApproved

Nicotine DependenceApproved

HysterectomyApproved

Terminated

Peripheral NeuropathyApproved

Completed

SeizureApproved

Terminated

Chronic Pelvic PainPreclinical

Not yet recruiting

FibromyalgiaApproved

Completed

Bilateral Tonic-Clonic SeizureApproved

Approved

Intervertebral Disk DegenerationApproved

Approved

Opioid DependenceApproved

Approved

RadiculopathyApproved

Approved

Nicotine DependenceApproved

Approved

Showing 10 of 69 indications

Competition

Competitive Landscape

706 competitors in Breast Cancer

#DrugCompanyPhaseTrials

Lyrica

PPfizer's Upjohn has merged with Mylan to form Viatris Inc.

Approved

4 2

Adenocard

Astellas

Preclinical

2 3

Lexiscan

Astellas

Preclinical

1 4

Voltaren

Novartis

Preclinical

1 5

Zolymbus

AbbVie

Preclinical

1 6

Blenoxane

Bristol-Myers Squibb

Preclinical

1 7

Methylthioninium Chloride

PProvepharm SAS

Preclinical

3 8

MS Contin

HHikma Pharmaceuticals LLC

Preclinical

3 9

Duragesic-100

CCephalon

Preclinical

2 10

MS Contin

HHikma Pharmaceuticals LLC

Preclinical

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q4 2026

Phase 2Not yet recruiting

Postherpetic Neuralgia

NCT07275762

Phase 2Recruiting

Neuropathic Pain

NCT06766916

Q1 2027

N/ARecruiting

Mastectomy

NCT07421427

Q2 2027

Post-ApprovalRecruiting

Neuropathic Pain

NCT07451431

Q3 2027

N/ARecruiting

Fibromyalgia

NCT07196657

N/ARecruiting

Fibromyalgia

NCT07208357

Clinical

Trials by Indication[1]

Neuropathic Pain29 trials

Pregabalin Peripheral Neuropathic Pain Study

Completed·PPfizer's Upjohn has merged with Mylan to form Viatris Inc.·Phase 3·NCT00141219·241 enrolled

Crisugabalin for Radiotherapy-Related Neuropathic Pain

Recruiting·SSun Yat-Sen Memorial Hospital of Sun Yat-Sen University·Phase 2·NCT06766916·172 enrolled

Clinical Trial to Evaluate the Efficacy and Safety of 'GLA5PR GLARS-NF1 Tab.' in Peripheral Neuropathic Pain

Completed· Daewon Pharmaceutical Co., Ltd. logo

Daewon Pharmaceutical Co., Ltd.·Phase 3·NCT03221907·352 enrolled

Show 26 more trials

Diabetic Peripheral Neuropathic Pain (DPNP)

Completed· Bristol-Myers Squibb logo

Bristol-Myers Squibb·Phase 2·NCT01314222·178 enrolled

An Open-Label Comparison of Duloxetine to Other Alternatives for the Management of Diabetic Peripheral Neuropathic Pain

Completed· Eli Lilly logo

Eli Lilly·Phase 4·NCT00385671·407 enrolled

Efficacy Of Pregabalin In Subjects With Post-Stroke Central Neuropathic Pain

Completed·PPfizer's Upjohn has merged with Mylan to form Viatris Inc.·Phase 4·NCT00313820·220 enrolled

A Study of Duloxetine (LY248686) in Participants With Diabetic Peripheral Neuropathic Pain (DPNP)

Completed· Eli Lilly logo

Eli Lilly·Phase 4·NCT02417935·304 enrolled

Study of the Safety and Efficacy of RGH-896 in Patients With Diabetic Peripheral Neuropathic Pain

Completed·FForest Laboratories·Phase 2·NCT00838799·458 enrolled

Placebo-controlled Safety and Efficacy Study of Pregabalin in Subjects With Post-traumatic Peripheral Neuropathic Pain

Completed·PPfizer's Upjohn has merged with Mylan to form Viatris Inc.·Phase 3·NCT01701362·542 enrolled

Efficacy and Safety of Mirogabalin in Diabetic Peripheral Neuropathic Pain

Recruiting·—·Phase 4·NCT07451431·78 enrolled

Pregabalin and Orofacial Neuropathic Pain

Terminated·UUniversity of Toronto·Phase 2·NCT00852436·1 enrolled

An Open-Label Long-Term Study Of Pregabalin For The Treatment Of Central Neuropathic Pain

Completed·PPfizer's Upjohn has merged with Mylan to form Viatris Inc.·Phase 3·NCT01202227·104 enrolled

Localized Neuropathic Pain: Topical Treatment Versus Systemic Treatment

Terminated·UUniversity Hospital, Antwerp·Phase 4·NCT03348735·33 enrolled

Study To Assess The Reproducibility And Sensitivity Of Quantitative Sensory Testing In Patients With Neuropathic Pain

Completed· Pfizer logo

Pfizer·N/A·NCT01117766·31 enrolled

Evaluate Long-Term Safety and Efficacy of Pregabalin in Patients With Chronic Neuropathic Pain.

Completed· Pfizer logo

Pfizer·Phase 3·NCT00141362·325 enrolled

Amitriptyline or Pregabalin to Treat Neuropathic Pain in Incurable Cancer

Unknown status·RRadboud University Medical Center·Phase 3·NCT00740571·130 enrolled

Neuropathic Pain Assessment Comparing Pregabalin and Paroxetine in Management of MS-induced Neuropathic Pain

Completed·UUniversity of Manitoba·Phase 3·NCT00291148·75 enrolled

Pregabalin Versus Placebo In The Treatment Of Neuropathic Pain Associated With HIV Neuropathy

Terminated·PPfizer's Upjohn has merged with Mylan to form Viatris Inc.·Phase 3·NCT01049217·377 enrolled

Evaluation in the Treatment of Neuropathic Pain Post Breast Surgery

Completed·IInstitut Cancerologie de l'Ouest·Phase 3·NCT03794388·140 enrolled

Symptomatic Treatment Of Patients With Neuropathic Pain With LYRICA

Completed·PPfizer's Upjohn has merged with Mylan to form Viatris Inc.··NCT00843284·691 enrolled

Mechanism-based Choice of Therapy for Neuropathic Pain

Completed·RRambam Health Care Campus·N/A·NCT01359514·32 enrolled

A Methodology Study Of Brain Imaging Of Pain-Killers In Post-Traumatic Neuropathic Pain Patients

Completed·PPfizer's Upjohn has merged with Mylan to form Viatris Inc.·N/A·NCT00610155·18 enrolled

A 2-part Trial to Learn More About How BAY1817080 Works, How Safe it is, and What the Right Dose is for Participants With Diabetic Neuropathic Pain

Terminated· Bayer logo

Bayer·Phase 2·NCT04641273·154 enrolled

Evaluate the Efficacy and Safety of JMKX000623 in Participants With Diabetic Peripheral Neuropathic Pain

Recruiting·JJemincare·Phase 2·NCT06221241·220 enrolled

Effect of Pregabalin in Patients With Radiotherapy-related Neuropathic Pain

Completed·SSun Yat-Sen Memorial Hospital of Sun Yat-Sen University·Phase 2·NCT01869569·137 enrolled

A Multicenter Study Comparing the Analgesic Effects and Safety of ABT-639 Compared to Placebo in Subjects With Diabetic Neuropathic Pain

Completed· AbbVie logo

AbbVie·Phase 2·NCT01345045·193 enrolled

Pregabalin add-on for Neuropathic Pain in Cervical Myelopathy

Unknown status·SSeoul National University Hospital·Phase 1·NCT03618589·60 enrolled

A Study to Assess the Safety and Efficacy of 7 Days Treatment With a Novel Analgesic in Subjects With Peripheral Neuropathic Pain

Terminated·GGrünenthal GmbH·Phase 2·NCT01485094·114 enrolled

A Study to Compare QUTENZA With Pregabalin for the Treatment of Peripheral Neuropathic Pain (PNP) After 8 Weeks of Treatment

Completed· Astellas logo

Astellas·Phase 4·NCT01713426·568 enrolled

Pregabalin20 trials

The Effect of Gabapentin (Neurentin) and Pregabalin (Lyrica) in Pain Reduction After Photorefractive Keratectomy

Unknown status·SShahid Beheshti University of Medical Sciences·Phase 1·NCT01122004

Efficacy of Pregabalin in Patients With Radicular Pain

Completed·NNorthwestern University·Phase 4·NCT00908375·39 enrolled

Effects of Pregabalin, Duloxetine & Amitriptyline on Pain & Sleep

Completed·UUniversity of Surrey·Phase 2/3·NCT00370656·90 enrolled

Show 17 more trials

Comparing Pregabalin and Placebo in Patients With Persistent Globus Sensation

Unknown status·UUniversitaire Ziekenhuizen KU Leuven·Phase 4·NCT05432843·90 enrolled

Role of Pregabalin in Treatment of Post-Op Pain in Fracture Patients

Completed·UUniversity of Alabama at Birmingham·Phase 1·NCT00583869·86 enrolled

Abuse Liability of Pregabalin and Its Effects on Benzodiazepine Withdrawal Symptoms

Terminated·CCentre for Addiction and Mental Health·Phase 4·NCT02423018·1 enrolled

Pregabalin in CIPN

Completed·WWashington University School of Medicine·N/A·NCT02394951·26 enrolled

Pregabalin and Radicular Pain Study (PARPS)

Completed·SSingapore General Hospital·Phase 4·NCT01061697·50 enrolled

The Effects of Peri-operative Pregabalin Administration on Post-operative Analgesia in Patients Undergoing Coronary Bypass Grafting

Unknown status·UUniversity of Manitoba·Phase 3·NCT00623285·40 enrolled

Impact of Pregabalin in Chronic Users vs. a Perioperative Limited Prescription on Oxycodone Requirement

Completed·—··NCT02866396·70 enrolled

Effect of Pregabalin on Immediate Post-operative and Longterm Pain

Completed·TTurku University Hospital·Phase 4·NCT02464813·64 enrolled

PHOTOTHERAPY VERSUS PREGABALIN IN TREATMENT OF REFRACTORY UREAMIC PRURITIS

Unknown status·—·Phase 2·NCT04660773·40 enrolled

A Post Marketing Surveillance Study On Pregabalin (Lyrica) On Efficacy, Safety And Tolerability Of Pregabalin

Completed·PPfizer's Upjohn has merged with Mylan to form Viatris Inc.··NCT00892008·2,278 enrolled

P4 (Pregabalin for Peripheral Posttraumatic Pain)

Completed·PPfizer's Upjohn has merged with Mylan to form Viatris Inc.·Phase 4·NCT00292188·255 enrolled

Efficacy, Safety, Tolerability and Pharmacokinetics of Concomitant Administration of Tramadol With Duloxetine or Pregabalin

Withdrawn·TTurku University Hospital·Phase 4·NCT01116531

The Effect of Pregabalin on Pain of Propofol Injection

Completed·KKyungpook National University Hospital·N/A·NCT02668094·120 enrolled

Pre-operative Pregabalin and Ketamine to Prevent Phantom Pain

Withdrawn·UUniversity of Texas Southwestern Medical Center·Phase 3·NCT02311777

Study to Find Out if Therapy With the Drug Pregabalin Relieves Pain During Shingles Compared With Placebo

Terminated·UUniversity of California, San Francisco·Phase 2·NCT00352651·34 enrolled

Pregabalin Treatment for RDEB Pain and Itch

Completed·TThe Hospital for Sick Children·Phase 3·NCT03928093·1 enrolled

A Comparison of Pregabalin (Lyrica®) to Placebo in Pain Relief After Photorefractive Keratectomy (PRK) Surgery

Completed·559th Medical Wing·N/A·NCT01097577·130 enrolled

Fibromyalgia16 trials

The Efficacy and Safety of Pregabalin and Crisugabalin in Patients With Fibromyalgia

Recruiting·—·N/A·NCT07196657·1,116 enrolled

The Efficacy and Safety of Pregabalin Combined With Toludesvenlafaxine in Patients With Fibromyalgia

Recruiting·—·N/A·NCT07208357·384 enrolled

Treatment of Pain Associated With Fibromyalgia

Completed· Daiichi Sankyo logo

Daiichi Sankyo·Phase 3·NCT02187159·1,270 enrolled

Show 13 more trials

Mechanism-based Choice of Therapy: Can Treatments Success in Fibromyalgia Patients be Coupled to Psychophysical Pain Modulation Profile?

Unknown status·TTel-Aviv Sourasky Medical Center·N/A·NCT01268631·150 enrolled

Treatment of Pain Associated With Fibromyalgia

Completed· Daiichi Sankyo logo

Daiichi Sankyo·Phase 3·NCT02187471·1,301 enrolled

Safety and Efficacy Study of Pregabalin in Fibromyalgia

Completed·PPfizer's Upjohn has merged with Mylan to form Viatris Inc.·Phase 3·NCT00151489·1,020 enrolled

Effects Of Pregabalin (Lyrica) On Sleep Maintenance In Subjects With Fibromyalgia

Completed·PPfizer's Upjohn has merged with Mylan to form Viatris Inc.·Phase 3·NCT00883740·119 enrolled

A Controlled Pregabalin Trial In Fibromyalgia

Completed·PPfizer's Upjohn has merged with Mylan to form Viatris Inc.·Phase 3·NCT00230776·740 enrolled

The Effect of Central Sensitization on Treatment Response in Patients With Fibromyalgia

Unknown status·MMarmara University··NCT05020600·40 enrolled

Randomized, Double-Blind, Placebo-Controlled Study Of Pregabalin In Patients With Fibromyalgia

Completed·PPfizer's Upjohn has merged with Mylan to form Viatris Inc.·Phase 3·NCT00830167·498 enrolled

The Efficacy and Safety of Pregabalin Combined With Desvenlafaxine in Patients With Fibromyalgia

Recruiting·—·N/A·NCT07171320·384 enrolled

Special Investigation of Pregabalin for Fibromyalgia (Regulatory Post Marketing Commitment Plan)

Completed·PPfizer's Upjohn has merged with Mylan to form Viatris Inc.··NCT01773993·534 enrolled

The Efficacy and Safety of Pregabalin Combined With Dexmedetomidine in Patients With Fibromyalgia

Recruiting·—·N/A·NCT07230197·400 enrolled

Fixed Versus Flexible Dosing of Pregabalin in Patients With Fibromyalgia

Completed·—·Phase 4·NCT01226667·174 enrolled

Pregabalin In Adolescent Patients With Fibromyalgia

Completed·PPfizer's Upjohn has merged with Mylan to form Viatris Inc.·Phase 4·NCT01020526·63 enrolled

Efficacy and Safety of Pregabalin/Tizanidine vs. Pregabalin in Patients With Fibromyalgia

Not yet recruiting·—·N/A·NCT07382921·164 enrolled

Seizure15 trials

To Evaluate the Long-Term Safety and Efficacy of Pregabalin in Patients With Partial Seizures.

Completed· Pfizer logo

Pfizer·Phase 3·NCT00141336·750 enrolled

Once-A-Day Pregabalin For Partial Seizures

Completed·PPfizer's Upjohn has merged with Mylan to form Viatris Inc.·Phase 3·NCT01262677·325 enrolled

Comparative Study Of Pregabalin And Gabapentin As Adjunctive Therapy In Subjects With Partial Seizures

Completed·PPfizer's Upjohn has merged with Mylan to form Viatris Inc.·Phase 4·NCT00537940·482 enrolled

Show 12 more trials

Levetiracetam or Pregabalin in Treating Seizures in Patients Undergoing Chemotherapy and/or Radiation Therapy For Primary Brain Tumors

Completed·DDr Andrea Rossetti·Phase 2·NCT00629889·52 enrolled

Evaluation of Long-Term Safety and Efficacy of Pregabalin in Patients With Partial Seizures.

Completed· Pfizer logo

Pfizer·Phase 3·NCT00150293·337 enrolled

Pregabalin Versus Levetiracetam In Partial Seizures

Completed·PPfizer's Upjohn has merged with Mylan to form Viatris Inc.·Phase 3·NCT00537238·509 enrolled

A 12-Month Study To Evaluate The Safety And Tolerability Of Pregabalin As Add-On Therapy In Pediatric Subjects 1 Month To 16 Years Of Age With Partial Onset Seizures And Pediatric And Adult Subjects 5 To 65 Years Of Age With Primary Generalized Tonic-Clonic Seizures

Completed·PPfizer's Upjohn has merged with Mylan to form Viatris Inc.·Phase 3·NCT01463306·605 enrolled

To Evaluate Long-Term Safety and Efficacy of Pregabalin in Patients With Partial Seizures.

Completed· Pfizer logo

Pfizer·Phase 3·NCT00141245·325 enrolled

Pregabalin In Partial Seizures: An Open-Label, International, Multicenter Add-On Therapy Trial.

Completed·PPfizer's Upjohn has merged with Mylan to form Viatris Inc.·Phase 4·NCT00141427·540 enrolled

Pregabalin In Partial Seizures (PREPS): An Open-Label, Multicenter Add On Therapy Trial

Terminated·PPfizer's Upjohn has merged with Mylan to form Viatris Inc.·Phase 4·NCT00407797·136 enrolled

Safety, Tolerability, and Pharmacokinetic Study of Pregabalin in Pediatric Patients With Partial Onset Seizures

Completed·PPfizer's Upjohn has merged with Mylan to form Viatris Inc.·Phase 1/2·NCT00437281·65 enrolled

Extension Study Of Long-Term Safety And Efficacy Of Pregabalin As Monotherapy (Lyrica) In Patients With Partial Seizures

Completed·PPfizer's Upjohn has merged with Mylan to form Viatris Inc.·Phase 3·NCT00596466·75 enrolled

To Evaluate the Long-Term Safety and Efficacy of Pregabalin in Patients With Partial Seizures

Completed· Pfizer logo

Pfizer·Phase 3·NCT00141388·455 enrolled

Pregabalin Open-Label Extension Trial in Patients With Partial Seizures

Completed· Pfizer logo

Pfizer·Phase 3·NCT00143143·300 enrolled

Lyrica (Pregabalin) Administered as an Add-on Therapy for Partial Seizures (LEADER).

Completed·PPfizer's Upjohn has merged with Mylan to form Viatris Inc.·Phase 4·NCT00288639·98 enrolled

Peripheral Neuropathy9 trials

Evaluation of Efficacy and Safety of VX-548 for Painful Diabetic Peripheral Neuropathy (DPN)

Completed· Vertex Pharmaceuticals logo

Vertex Pharmaceuticals·Phase 2·NCT05660538·194 enrolled

A Study In Patients With Neuropathic Pain From Diabetic Peripheral Neuropathy (DPN)

Completed·XXenoPort, Inc.·Phase 2·NCT00643760·421 enrolled

The Effect of Pregabalin on Pain Related to Walking in Patients With Diabetic Peripheral Neuropathy

Completed·—·Phase 3·NCT02927951·44 enrolled

Show 6 more trials

Evaluation of Efficacy and Safety of VX-993 for Pain Associated With Diabetic Peripheral Neuropathy

Recruiting· Vertex Pharmaceuticals logo

Vertex Pharmaceuticals·Phase 2·NCT06619860·300 enrolled

Pregabalin in the Treatment of Pain Due to Diabetic Peripheral Neuropathy

Completed·PPfizer's Upjohn has merged with Mylan to form Viatris Inc.·Phase 4·NCT00159679·167 enrolled

Prevention And Treatment Of Chemotherapy-Induced Peripheral Neuropathy In Subjects With Advanced Colorectal Cancer

Terminated·PPfizer's Upjohn has merged with Mylan to form Viatris Inc.·Phase 4·NCT00380874·64 enrolled

To Evaluate the Safety and Efficacy of Pregabalin in Patients With Painful Diabetic Peripheral Neuropathy.

Completed· Pfizer logo

Pfizer·Phase 3·NCT00150423·384 enrolled

Efficacy and Safety of Gabapentin/B-complex Versus Pregabalin in Diabetic Peripheral Neuropathy Pain Management

Completed· Merck & Co. logo

Merck & Co.·Phase 4·NCT01364298·353 enrolled

Safety of Pregabalin in the Treatment of Pain Due to Diabetic Peripheral Neuropathy

Completed·PPfizer's Upjohn has merged with Mylan to form Viatris Inc.·Phase 4·NCT00159731·160 enrolled

77 more indications

Postherpetic Neuralgia4 trials

A 13-Week, Randomized, Double-Blind, Multicenter, Placebo-Controlled Study Of Pregabalin For Postherpetic Neuralgia

Completed·PPfizer's Upjohn has merged with Mylan to form Viatris Inc.·Phase 3·NCT00394901·372 enrolled

Y-4 to Treat the Postherpetic Neuralgia

Not yet recruiting·NNeurodawn Pharmaceutical Co., Ltd.·Phase 2·NCT07275762·160 enrolled

Pregabalin Treatment Of Peripheral Neuropathic Pain Associated With Diabetic Peripheral NeP (DPN), Postherpetic Neuralgia (PHN), HIV-related NeP (HIV), and Chemotherapy Induced NeP

Completed·PPfizer's Upjohn has merged with Mylan to form Viatris Inc.·Phase 4·NCT00407511·121 enrolled

Show 1 more trial

Study to Assess the Efficacy, Safety, and Tolerability of ADL5747 in Participants With Postherpetic Neuralgia

Terminated· Merck & Co. logo

Merck & Co.·Phase 2·NCT01058642·41 enrolled

Partial Epilepsy3 trials

Systematic Review: Retigabine for Adjunctive Therapy in Partial Epilepsy

Completed· GSK logo

GSK··NCT01587339·6,498 enrolled

Effect on Anxiety in Partial Epilepsy Patients Treated With Pregabalin

Terminated·NNortheast Regional Epilepsy Group·Phase 4·NCT01128712·4 enrolled

To Evaluate the Long-Term Safety of Pregabalin in Refractory Partial Epilepsy.

Completed· Pfizer logo

Pfizer·Phase 2·NCT00141414·82 enrolled

Post-thoracotomy Pain3 trials

Adding Amantadine to Pregabalin on Occurrence of Post-thoracotomy Pain Syndrome

Completed·—·N/A·NCT06833203·60 enrolled

Pregabalin and Post-thoracotomy Pain

Completed·QQueen's University·Phase 4·NCT00663962·15 enrolled

The Effect of Perioperative Pregabalin on the Incidence of Chronic Post-thoracotomy Pain Syndrome

Withdrawn·QQueen's University·Phase 3·NCT00998816

Analgesic3 trials

Assessment of the Analgesic Effects of PF-06273340 in Healthy Volunteers Using Evoked Pain Endpoints

Completed· Pfizer logo

Pfizer·Phase 1·NCT02260947·20 enrolled

Assessment of the Analgesic Effects of PF-06372865 in Healthy Volunteers Using Evoked Pain Endpoints

Completed· Pfizer logo

Pfizer·Phase 1·NCT02238717·20 enrolled

MAST Trial: Multi-modal Analgesic Strategies in Trauma

Completed·TThe University of Texas Health Science Center, Houston·Phase 4·NCT03472469·1,561 enrolled

Anxiety3 trials

Perioperative Pregabalin Use, Rehabilitation, Pain Outcomes and Anxiety Following Hip Surgery

Unknown status·SSunnybrook Health Sciences Centre·Phase 4·NCT00762099·184 enrolled

Comparing the Efficacy of Pregabalin and Hydroxyzine on the Anxiety Score

Completed·PPoitiers University Hospital·Phase 2·NCT01675986·306 enrolled

Trial of Pregabalin, Alprazolam, and Placebo in Subjects With Anxiety Prior to Dental Procedure

Completed·PPfizer's Upjohn has merged with Mylan to form Viatris Inc.·Phase 2·NCT00245609·90 enrolled

Neuralgia3 trials

A Study To Compare Pregabalin/PF-00489791 Combination Versus Pregabalin Alone In Post-Herpetic Neuralgia

Completed· Pfizer logo

Pfizer·Phase 2·NCT00599638·72 enrolled

Efficacy of Pregabalin for the Treatment of Acute Herpetic Neuralgia

Completed·—·Phase 4·NCT03809702·82 enrolled

Pregabalin Treatment and Prevention Post-herpetic Neuralgia

Unknown status·SSecond Affiliated Hospital of Guangzhou Medical University·Phase 3·NCT03186443·342 enrolled

Post Operative Pain3 trials

Pre- Versus Post-incisional Pregabalin for Postoperative Pain Attenuation and Analgesics Spare in Orthopedic Oncologic Patients

Unknown status·TTel-Aviv Sourasky Medical Center·N/A·NCT01359059·80 enrolled

Combination of Duloxetine and Pregabalin to Improve Postoperative Pain

Completed·—·Phase 1·NCT04862845·90 enrolled

Combination Effects of Pregabalin and Dexmedetomidine on Postoperative Pain

Completed·WWonkwang University Hospital·Phase 4·NCT03512574·150 enrolled

Generalized Anxiety Disorder3 trials

Pregabalin in the Treatment of Patients With Generalized Anxiety Disorder (GAD).

Completed·PPfizer's Upjohn has merged with Mylan to form Viatris Inc.·Phase 3·NCT00413010·356 enrolled

Comparison of Pregabalin Versus Venlafaxine XR and Placebo in the Treatment of Generalized Anxiety Disorder

Completed·PPfizer's Upjohn has merged with Mylan to form Viatris Inc.·Phase 3·NCT00151450·390 enrolled

Efficacy and Safety of Pregabalin vs Placebo for Generalized Anxiety Disorder (GAD) Symptoms in Subjects Discontinuing Benzodiazepine Treatment and Remaining 6 Weeks on Study Medication, Free From Benzodiazepine Use.

Completed·PPfizer's Upjohn has merged with Mylan to form Viatris Inc.·Phase 3·NCT00368745·108 enrolled

Breast Cancer2 trials

Swiss Multi-centre, Randomized, Placebo Controlled Trial of Pregabalin for Prevention of Persistent Pain in High Risk Patients Undergoing Breast Cancer Surgery

Terminated·BBenno Rehberg-Klug·Phase 3·NCT03216187·126 enrolled

The Effects of Peri-Operative Pregabalin on Post-Operative Pain Following Breast Cancer Surgery With Axillary Node Dissection: A Pilot Study

Completed·NNova Scotia Health Authority·Phase 3·NCT00852683·70 enrolled

Chronic pain2 trials

Chronic Pain Management After Herniorraphy

Completed·EErasmus Medical Center·Phase 3·NCT00772291·140 enrolled

The Effect of Pregabalin and Dexamethasone on Acute and Chronic Pain After Lumbar Spinal Surgery

Completed·YYonsei University·N/A·NCT01168531·108 enrolled

Preoperative2 trials

Analgetic Effect of Preoperative Pregabalin in Patients Undergoing Nephrectomy

Completed·MMedical University of Graz·Phase 3·NCT00957177·20 enrolled

Effect of Preoperative Pregabalin on Propofol Induction Dose

Completed·UUniversité de Sherbrooke·Phase 4·NCT01158859·50 enrolled

Hysterectomy2 trials

Effect of Pregabalin on Post Operative Pain in Abdominal Hysterectomy Under Spinal Anesthesia With Intrathecal Morphine

Completed·MMahidol University·Phase 4·NCT02285010·125 enrolled

Preoperative Oral Pregabalin Effect on Inhalational Anesthetic Requirements ln Hysterectomy Under General Anesthesia

Completed·NNesrine El-Refai·Phase 3·NCT03302208·50 enrolled

Diabetic Neuropathy2 trials

Evaluation of the Impact of Training on Outcome Measures in Subjects With Painful Diabetic Neuropathy

Unknown status·AAnalgesic Solutions·Phase 4·NCT01770964·90 enrolled

A Study for Treatment of Pain in Patients With Diabetic Neuropathy.

Completed· Eli Lilly logo

Eli Lilly·Phase 2·NCT00785577·273 enrolled

Inguinal hernia2 trials

Surgical Pain After Inguinal Hernia Repair (SPAIHR)

Completed·PPfizer's Upjohn has merged with Mylan to form Viatris Inc.·Phase 3·NCT00551135·425 enrolled

Efficacy of Pre-operative Oral Pregabalin in Ambulatory Inguinal Hernia Repair for Post Operative Pain

Unknown status·UUniversity of Malaya·Phase 3·NCT01450345·72 enrolled

Neuropathy2 trials

Study of Pregabalin Versus Placebo in the Treatment of Nerve Pain Associated With HIV Neuropathy

Completed·PPfizer's Upjohn has merged with Mylan to form Viatris Inc.·Phase 3·NCT00232141·302 enrolled

Evaluation of Pregabalin in Idiopathic Small Fiber Neuropathy

Terminated·UUniversity of Alberta·N/A·NCT00787462·3 enrolled

Spinal Cord Injury2 trials

Pregabalin for the Treatment and Prevention of Spinal Cord Injury Neuropathic Pain

Unknown status·JJulian Taylor Green·Phase 4·NCT01479556·82 enrolled

To Evaluate Long-Term Safety and Efficacy of Pregabalin in the Treatment of Neuropathic Pain After Spinal Cord Injury.

Completed· Pfizer logo

Pfizer·Phase 3·NCT00141375·132 enrolled

Restless Legs Syndrome2 trials

Lyrica Dose Response Study With Restless Legs Syndrome (RLS) Patients

Completed·PPfizer's Upjohn has merged with Mylan to form Viatris Inc.·Phase 2·NCT00676403·137 enrolled

Polysomnography Study Of Pregabalin And Pramipexole Versus Placebo In Patients With Restless Legs Syndrome And Associated Sleep Disturbance

Completed·PPfizer's Upjohn has merged with Mylan to form Viatris Inc.·Phase 3·NCT00991276·85 enrolled

Mastectomy2 trials

Adding Amantadine or Duloxetine to Pregabalin on Occurrence of Post Mastectomy Pain Syndrome

Recruiting·—·N/A·NCT07421427·150 enrolled

Perioperative Administration of Pregabalin for Pain After Mastectomy

Completed·SSeverance Hospital·Phase 4·NCT00938548·70 enrolled

Irritable Bowel Syndrome2 trials

A Placebo-Controlled Trial of Pregabalin (Lyrica) for Irritable Bowel Syndrome

Completed·MMayo Clinic·Phase 2·NCT00977197·85 enrolled

Pregabalin on Colonic Motor and Sensory Function in Constipation Predominant Irritable Bowel Syndrome

Completed·MMayo Clinic·Phase 4·NCT01331213·18 enrolled

Post-craniotomy2 trials

Effects of Perioperative Pregabalin for Post-Craniotomy Pain

Withdrawn·UUnity Health Toronto·Phase 4·NCT01591980

Pregabalin for Post-craniotomy Pain Control

Unknown status·TTel-Aviv Sourasky Medical Center·N/A·NCT01612832·100 enrolled

Total Knee Arthroplasty2 trials

Outcomes Of Perioperative Pregabalin On Total Knee Arthroplasty

Completed·NNational University Hospital, Singapore·Phase 3·NCT02954484·116 enrolled

Pregabalin, Celecoxib, Total Knee Arthroplasty and Intrathecal Morphine

Completed·—·Phase 4·NCT01344213·100 enrolled

Postoperative Pain Control2 trials

Comparison of Oral Gabapentin and Pregabalin in Postoperative Pain Control After Photorefractive Keratectomy

Terminated·LLoma Linda University·N/A·NCT00954187·8 enrolled

Pre- Versus Post-Incisional Pregabalin for Postoperative Pain Control

Unknown status·TTel-Aviv Sourasky Medical Center·N/A·NCT01614236·100 enrolled

Postoperative Analgesia2 trials

Postoperative Analgesia After Laparoscopic Living Donor Nephrectomy

Completed·OOslo University Hospital·Phase 4·NCT01059331·80 enrolled

Evaluation of Preoperative Use of Pregabalin on Postoperative Analgesia After Laparoscopic Colorectal Surgery

Completed·LLarissa University Hospital·N/A·NCT01940224·50 enrolled

Pain Control2 trials

Study Evaluating the Effects of Toradol and Lyrica for Pain Control After Donor Nephrectomy

Completed·UUniversity of Utah·Phase 2·NCT03669081·64 enrolled

Preoperative Pain Control in Liver Surgery Patients

Completed·—·N/A·NCT01923948·40 enrolled

Chronic Pancreatitis1 trial

Pain and Chronic Pancreatitis - Clinical End Experimental Studies

Completed·—·Phase 2/3·NCT00755573·64 enrolled

Remifentanil1 trial

Pregabalin and Remifentanil - Analgesia and Ventilation

Completed·OOslo University Hospital·Phase 4·NCT01419405·12 enrolled

Sedation1 trial

Melatonin vs Pregabalin for Anxiolysis and Sedation

Completed·MMenoufia University·Phase 4·NCT05221151·78 enrolled

Bone pain1 trial

A Study To Evaluate Pregabalin In The Treatment Of Moderate To Severe Chronic Bone Pain Related To Metastatic Cancer

Terminated·PPfizer's Upjohn has merged with Mylan to form Viatris Inc.·Phase 4·NCT00381095·152 enrolled

Anterior Cruciate Ligament Reconstruction1 trial

Perioperative Administration of Pregabalin in Patients Undergoing Arthroscopic Anterior Cruciate Ligament Reconstruction

Completed·PPrince of Songkla University·Phase 4·NCT01242332·60 enrolled

Prevention1 trial

Pain Prevention and Treatment Through the Enhancement of the Anti-nociceptive Component of Pain Modulation Profiles

Completed·RRambam Health Care Campus·N/A·NCT02020122·5 enrolled

Muscle Cramp1 trial

A Study Evaluating the Efficacy and Safety of Pregabalin Against Frequent Muscle Cramp in Patients With Liver Cirrhosis

Completed·SSeoul National University Boramae Hospital·Phase 3·NCT01271660·60 enrolled

Essential Tremor1 trial

Pregabalin (Lyrica) for the Treatment of Essential Tremor

Completed·UUniversity of South Florida·Phase 4·NCT00584376·29 enrolled

Surgery1 trial

Preventing Pain After Heart Surgery

Completed·BBarts & The London NHS Trust·Phase 4·NCT01480765·150 enrolled

Outcome1 trial

Lumbar Stenosis Outcomes Research (LUSTOR)

Completed·UUniversity of Rochester·Phase 4·NCT00638443·29 enrolled

Sevoflurane1 trial

Pregabalin Reduce the Sevoflurane Requirement

Completed·MMansoura University·Phase 2·NCT01571804·42 enrolled

Withdrawal Syndrome1 trial

Pregabalin for Opiate Withdrawal Syndrome

Completed·SSt. Petersburg Bekhterev Research Psychoneurological Institute·Phase 4·NCT03017430·100 enrolled

Gulf War Illness1 trial

Research Examining Gulf War Illness in Our Nations Service Members

Terminated·VVA Office of Research and Development·Phase 2·NCT01846182·112 enrolled

Dexamethasone1 trial

Effect of Paracetamol, Pregabalin and Dexamethasone on Pain and Opioid Requirements in Patients After Hip Operations

Completed·GGlostrup University Hospital, Copenhagen·Phase 4·NCT00235261·120 enrolled

Hot flashes1 trial

A Study Following Women in Menopause Treated With a Non-hormonal Therapy for Hot Flashes and Night Sweats

Active, not recruiting· Astellas logo

Astellas··NCT06049797·999 enrolled

Arthralgia1 trial

Exploratory Study on the Use of Pregabalin for the Treatment of Taxol Related Arthralgia-Myalgia

Unknown status·—·Phase 2·NCT02024568·38 enrolled

Laparoscopic Cholecystectomy1 trial

Pregabalin and Analgesia After Laparoscopic Cholecystectomy

Completed·LLarissa University Hospital·N/A·NCT01321801·50 enrolled

Trial1 trial

[S,S]-Reboxetine Add-On Trial

Terminated· Pfizer logo

Pfizer·Phase 2·NCT00334685·136 enrolled

Interleukin1 trial

Pregabalin on Interleukin-6 Levels in Living Donor Kidney

Completed·FFederal University of São Paulo·Phase 2·NCT01529190·40 enrolled

Dexmedetomidine1 trial

The Effect of Dexmedetomidine, Melatonin and Pregabalin

Unknown status·EEgymedicalpedia·Phase 1·NCT05829148·120 enrolled

Schizophrenia1 trial

Pregablin for Anxiety-comorbidity in Patients With Schizophrenia

Completed·UUniversity of Aarhus·Phase 4·NCT01496690·54 enrolled

Coronary Artery Bypass1 trial

Pregabalin Versus Dexmedetomidine for Delirium Treatment After Coronary Artery Bypass Grafting

Recruiting·TTanta University·Phase 4·NCT05640453·70 enrolled

Hypotensive Anesthesia1 trial

Pregabalin Effects on Hypotensive Anesthesia During Spine Surgery.

Completed·MMansoura University·N/A·NCT03301025·106 enrolled

Abortion1 trial

Prophylactic Pregabalin to Decrease Pain During Medical Abortion

Completed·UUniversity of Hawaii·Phase 4·NCT02782169·110 enrolled

Arterial Occlusive Disease1 trial

Magnesium Oral Supplementation to Reduce Pain Inpatients With Severe Peripheral Arterial Occlusive Disease

Unknown status·AAzienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia·N/A·NCT02455726·150 enrolled

Bunion1 trial

Bunionectomy Study (0000-063)

Completed· Merck & Co. logo

Merck & Co.·Phase 1·NCT00601458·100 enrolled

Delirium1 trial

Pregabalin Versus Dexmedetomidine for Delirium Prevention After Cardiac Surgery

Completed·TTanta University·Phase 4·NCT05640479·60 enrolled

Anxiolytic Effect1 trial

Analgetic and Anxiolytic Effect of Preoperative Pregabalin

Completed·—·Phase 4·NCT00353704·50 enrolled

Acetaminophen1 trial

A Phase 1 Study to Evaluate Pregabalin and Acetaminophen in Healthy Volunteers

Completed·NNevakar, Inc.·Phase 1·NCT04265456·63 enrolled

Herpes Zoster1 trial

Comparative Efficacy of Pregabalin and Lacosamide in Patients With Herpes Zoster and Post Herpetic Neuralgia

Recruiting·—·N/A·NCT06969417·50 enrolled

Dementia1 trial

Pain in Patients With Dementia and Behavioural Disturbances

Completed·UUniversity of Bergen·Phase 2/3·NCT01021696·352 enrolled

Ischemia1 trial

Randomized Study of Pregabalin for Pain Reduction in Patients With Rest Pain and Lower Limb Ischemia

Terminated·KKarolinska Institutet·Phase 4·NCT00403780·18 enrolled

Alcohol Use Disorder1 trial

Pregabalin as Treatment for Alcohol Use Disorder

Completed·NNew York State Psychiatric Institute·Phase 2·NCT03256253·18 enrolled

Drug Therapy1 trial

Effect of Preventional Drug Therapy on Pain Regulation Mechanisms Among SCI

Unknown status·SSheba Medical Center·Phase 4·NCT03748290·50 enrolled

Chronic Prostatitis1 trial

Efficacy & Safety Study of Pregabalin to Treat Chronic Prostatitis/Chronic Pelvic Pain Syndrome (CP/CPPS)

Completed·NNational Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)·Phase 3·NCT00371033·324 enrolled

Cognitive Function1 trial

Efficacy of Pregabalin and Duloxetine in Patients With PDPN: the Effect of Pain on Cognitive Function, Sleep and Quality of Life

Terminated·KKRKA·Phase 4·NCT04246619·254 enrolled

Migraine1 trial

Efficacy of Pregabalin in Migraine Prevention

Withdrawn·—·Phase 3·NCT00447369·70 enrolled

Interscalene Brachial Plexus Block1 trial

Pain Relief Following Arthroscopic Rotator Cuff Repair: Perioperative Pregabalin Administration Versus Interscalene Brachial Plexus Block

Unknown status·TTel-Aviv Sourasky Medical Center·N/A·NCT01359085·56 enrolled

Clinical Trial1 trial

A Clinical Trial to Compare The Pharmacokinetics of A Pregabalin GLARS Tablet 150mg With Immediate Release Formulation and to Assess The Effect of High Fat Diet in Healthy Male Subjects

Completed·GGL Pharm Tech Corporation·Phase 1·NCT01635751·30 enrolled

Dry Eye Symptoms1 trial

Can Pregabalin Reduce the Frequency and Severity of Dry Eye Symptoms After Laser-assisted in Situ Keratomileusis?

Completed·UUniversity of Miami·Phase 2/3·NCT02701764·43 enrolled

Shoulder pain1 trial

Effect of Pregabalin on Shoulder Pain in Patients With Central Sensitization After Arthroscopic Rotator Cuff Repair

Not yet recruiting·TThe Catholic University of Korea·Phase 4·NCT06367998·76 enrolled

Polyneuropathy1 trial

Imipramine and Pregabalin Combination in Painful Polyneuropathy

Unknown status·OOdense University Hospital·Phase 4·NCT01047488·75 enrolled

Lumbar Disc Surgery1 trial

Pregabalin Compared to Gabapentin for Pain Control in Lumbar Disc Surgery

Completed·—·Phase 3·NCT02120703·78 enrolled

Pain1 trial

Shifting Pain Modulation From Pro-to Anti-nociceptive

Terminated·RRambam Health Care Campus·N/A·NCT02672202·9 enrolled

Unknown status·OOttawa Hospital Research Institute·Phase 1/2·NCT02482818·40 enrolled

Cardiovascular1 trial

Pregabalin Stabilize Cardiovascular Response to Intubation

Completed·SShanghai Zhongshan Hospital·Phase 4·NCT03456947·90 enrolled

Obsessive-Compulsive Disorder1 trial

A Study of Pregabalin (Lyrica) Augmentation in Serotonin Reuptake Inhibitor-Refractory Obsessive Compulsive Disorder

Completed·MMcMaster University·Phase 4·NCT00994786·15 enrolled

Cognition1 trial

Simulated Driving Performance, Daytime Sedation and Cognition in Healthy Volunteers Taking Gralise, Neurontin or Lyrica

Completed·DDepomed·Phase 4·NCT03179345·32 enrolled

Complex Regional Pain Syndrome1 trial

Pregabalin Versus Placebo as an Add on for Complex Regional Pain Syndrome (CPRS) of the Upper Limb Managed by Stellate Ganglion Block (The PREGA Study)

Terminated·MMcMaster University·N/A·NCT00891397·14 enrolled

Spinal Anesthesia1 trial

The Effect of Pregabalin on the Spinal Anesthesia

Completed·KKyungpook National University Hospital·N/A·NCT02690506·44 enrolled

Unspecified2 trials

Study to Investigate the Pharmacodynamic Effects of IP2015 in Healthy Male Subjects Using the Intradermal Capsaicin Model

Unknown status·IInitiator Pharma·Phase 1·NCT05181852·24 enrolled

Pharmacovigilance in Gerontopsychiatric Patients

Terminated·HHannover Medical School·Phase 3·NCT02374567·407 enrolled

Regulatory

FDA Approval Timeline[5]

Dec 30, 2004

LYRICA

NDA NDA021446

Dec 30, 2004

LYRICA

NDA NDA021446

Feb 17, 2006

LYRICA

NDA NDA021446

Feb 17, 2006

LYRICA

NDA NDA021446

Oct 27, 2006

LYRICA

NDA NDA021446

Jun 21, 2007

LYRICA

NDA NDA021446

Apr 23, 2009

LYRICA

NDA NDA021446

Apr 23, 2009

LYRICA

NDA NDA021446

Jan 4, 2010

LYRICA

NDA NDA021446

Jan 4, 2010

LYRICA

NDA NDA022488

Oct 8, 2010

LYRICA

NDA NDA021446

Apr 26, 2011

LYRICA

NDA NDA021446

Apr 26, 2011

LYRICA

NDA NDA021446

Apr 26, 2011

LYRICA

NDA NDA022488

Apr 26, 2011

LYRICA

NDA NDA022488

Apr 26, 2011

LYRICA

NDA NDA022488

Jun 20, 2011

LYRICA

NDA NDA022488

Jun 20, 2011

LYRICA

NDA NDA021446

Aug 24, 2011

LYRICA

NDA NDA022488

Aug 24, 2011

LYRICA

NDA NDA021446

Apr 16, 2012

LYRICA

NDA NDA022488

Jun 20, 2012

LYRICA

NDA NDA021446

Feb 28, 2013

LYRICA

NDA NDA022488

Dec 23, 2013

LYRICA

NDA NDA022488

Dec 23, 2013

LYRICA

NDA NDA021446

Mar 9, 2016

LYRICA

NDA NDA022488

Mar 9, 2016

LYRICA

NDA NDA021446

Jul 8, 2016

LYRICA

NDA NDA021446

Dec 22, 2016

LYRICA

NDA NDA021446

Dec 22, 2016

LYRICA

NDA NDA022488

Oct 11, 2017

LYRICA CR

NDA NDA209501

Oct 11, 2017

LYRICA CR

NDA NDA209501

May 3, 2018

LYRICA

NDA NDA022488

May 3, 2018

LYRICA

NDA NDA021446

May 23, 2019

LYRICA

NDA NDA022488

May 23, 2019

LYRICA

NDA NDA021446

Apr 3, 2020

LYRICA

NDA NDA022488

Apr 3, 2020

LYRICA

NDA NDA021446

Apr 3, 2020

LYRICA CR

NDA NDA209501

Dec 13, 2023

LYRICA

NDA NDA021446

Dec 13, 2023

LYRICA CR

NDA NDA209501

Dec 13, 2023

LYRICA

NDA NDA022488

Apr 25, 2025

LYRICA

NDA NDA022488

Apr 25, 2025

LYRICA

NDA NDA021446

Apr 25, 2025

LYRICA CR

NDA NDA209501

Sources

References

[1]
ClinicalTrials.gov — 421 trial records for Pregabalin. U.S. National Library of Medicine, National Institutes of Health.
[2]
MedlinePlus Drug Information — Lyrica drug information. U.S. National Library of Medicine, National Institutes of Health.
[3]
ChEMBL — Pregabalin compound record. European Bioinformatics Institute (EMBL-EBI).
[4]
Open Targets Platform — Drug–disease associations for Pregabalin. EMBL-EBI & Wellcome Sanger Institute.
[5]
OpenFDA — FDA approval records (NDA NDA022488). U.S. Food & Drug Administration.
[6]
FDA Orange Book — Patent and exclusivity data for Lyrica. U.S. Food & Drug Administration.
[7]
SEC EDGAR — Pfizer's Upjohn has merged with Mylan to form Viatris Inc. company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Mechanism of Action: Voltage-Gated Calcium Channel Modulator[3]
Modality: Small molecule[3]
Highest Phase: Approved[1]
Company: PPfizer's Upjohn has merged with Mylan to form Viatris Inc.

Patent Landscape[6]

Patent Cliff

May 2, 2027

Earliest patent expiration — generic entry possible after this date

Patent #Expires

10022447Nov 2, 2026

8945620Nov 2, 2026

9144559Nov 2, 2026

9144559*PEDMay 2, 2027

10022447*PEDMay 2, 2027

1 more patents

8945620*PEDMay 2, 2027