Lyrica

(Pregabalin)

ApprovedSmall molecule

PPfizer's Upjohn has merged with Mylan to form Viatris Inc.

Pregabalin is used to treat nerve pain from diabetes or shingles, and it also helps reduce seizures and anxiety. It works by calming overactive nerves in the body that cause pain and other symptoms.[2] Lyrica is currently approved and in use across 89 indications[4].[1]

Lyrica is one of 1382 small molecule programs targeting Refractive Error. It is currently in Approved.

Indications

415

Total Trials

Active Trials

1,381

Competitors

FDA Applications

NDA/BLA/ANDA regulatory filings

Patents

Pipeline

Status by Indication[4][1]

Indication

Refractive ErrorApproved

Myofascial Pain SyndromeApproved

Bilateral Tonic-Clonic SeizureApproved

Chronic PancreatitisActive, not recruiting

Epilepsy With Generalized Tonic-Clonic SeizuresApproved

Nicotine DependenceApproved

Neuropathic PainActive, not recruiting

Low Back PainActive, not recruiting

Partial EpilepsyApproved

ProstatitisApproved

Refractive ErrorApproved

Approved

Myofascial Pain SyndromeApproved

Approved

Bilateral Tonic-Clonic SeizureApproved

Approved

Chronic PancreatitisPhase 2

Active, not recruiting

Epilepsy With Generalized Tonic-Clonic SeizuresApproved

Approved

Nicotine DependenceApproved

Approved

Neuropathic PainApproved

Active, not recruiting

Low Back PainApproved

Active, not recruiting

Partial EpilepsyApproved

Approved

ProstatitisApproved

Approved

Showing 10 of 82 indications

Competition

Competitive Landscape

2828 competitors in Breast Cancer

#DrugCompanyPhaseTrials

Lyrica

PPfizer's Upjohn has merged with Mylan to form Viatris Inc.

Approved

5 2

Tykerb

GSK

Preclinical

80 3

Nolvadex

SSan Diego Pacific Oncology & Hematology Associates

Preclinical

78 4

Prolia

Amgen

Preclinical

14 5

DATROWAY

Daiichi Sankyo

Preclinical

4 6

Lupron

EEastern Cooperative Oncology Group

Preclinical

5 7

MS Contin

HHikma Pharmaceuticals LLC

Preclinical

3 8

Tricor

JJagotec

Preclinical

1 9

Cortef

PPfizer's Upjohn has merged with Mylan to form Viatris Inc.

Preclinical

1 10

Acupan

YYonsei University

Preclinical

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q4 2026

Phase 2Not yet recruiting

Postherpetic Neuralgia

NCT07275762

N/ARecruiting

Neuropathic Pain

NCT06155916

Phase 2Recruiting

Neuropathic Pain

NCT06766916

Q1 2027

N/ARecruiting

Mastectomy

NCT07421427

Q2 2027

Post-ApprovalRecruiting

Neuropathic Pain

NCT07451431

Phase 3Recruiting

Peripheral Neuropathy

NCT06628908

Clinical

Trials by Indication[1]

Neuropathic Pain22 trials

Efficacy of Perioperative Pregabalin in Reducing the Incidence of Chronic Neuropathic Pain and Postthoracotomy Syndrome.

Completed·—·N/A·NCT00967135·110 enrolled

Sleep and Neuropathic Pain - Intervention Study on Pregabalin

Recruiting·HHelsinki University Central Hospital·N/A·NCT06155916·40 enrolled

Crisugabalin for Radiotherapy-Related Neuropathic Pain

Recruiting·SSun Yat-Sen Memorial Hospital of Sun Yat-Sen University·Phase 2·NCT06766916·172 enrolled

Show 19 more trials

Diabetic Peripheral Neuropathic Pain (DPNP)

Completed· Bristol-Myers Squibb logo

Bristol-Myers Squibb·Phase 2·NCT01314222·178 enrolled

Oxycodone and Pregabalin for the Treatment of Oncological Neuropathic Pain

Completed·AAssociazione Progetto Oncologia UMAN.A·Phase 2·NCT00637975·80 enrolled

Clinical Trial to Evaluate the Efficacy and Safety of 'GLA5PR GLARS-NF1 Tab.' in Peripheral Neuropathic Pain

Completed· Daewon Pharmaceutical Co., Ltd. logo

Daewon Pharmaceutical Co., Ltd.·Phase 3·NCT03221907·352 enrolled

Trial of Efficacy and Safety of Pregabalin in Subjects With Neuropathic Pain Associated With Lumbo-Sacral Radiculopathy

Completed·PPfizer's Upjohn has merged with Mylan to form Viatris Inc.·Phase 3·NCT00159705·276 enrolled

An Open-Label Comparison of Duloxetine to Other Alternatives for the Management of Diabetic Peripheral Neuropathic Pain

Completed· Eli Lilly logo

Eli Lilly·Phase 4·NCT00385671·407 enrolled

Efficacy Of Pregabalin In Subjects With Post-Stroke Central Neuropathic Pain

Completed·PPfizer's Upjohn has merged with Mylan to form Viatris Inc.·Phase 4·NCT00313820·220 enrolled

A Study of Duloxetine (LY248686) in Participants With Diabetic Peripheral Neuropathic Pain (DPNP)

Completed· Eli Lilly logo

Eli Lilly·Phase 4·NCT02417935·304 enrolled

Study of the Safety and Efficacy of RGH-896 in Patients With Diabetic Peripheral Neuropathic Pain

Completed·FForest Laboratories·Phase 2·NCT00838799·458 enrolled

Placebo-controlled Safety and Efficacy Study of Pregabalin in Subjects With Post-traumatic Peripheral Neuropathic Pain

Completed·PPfizer's Upjohn has merged with Mylan to form Viatris Inc.·Phase 3·NCT01701362·542 enrolled

Efficacy and Safety of Mirogabalin in Diabetic Peripheral Neuropathic Pain

Recruiting·—·Phase 4·NCT07451431·78 enrolled

Pregabalin and Orofacial Neuropathic Pain

Terminated·UUniversity of Toronto·Phase 2·NCT00852436·1 enrolled

An Open-Label Long-Term Study Of Pregabalin For The Treatment Of Central Neuropathic Pain

Completed·PPfizer's Upjohn has merged with Mylan to form Viatris Inc.·Phase 3·NCT01202227·104 enrolled

Localized Neuropathic Pain: Topical Treatment Versus Systemic Treatment

Terminated·UUniversity Hospital, Antwerp·Phase 4·NCT03348735·33 enrolled

Study To Assess The Reproducibility And Sensitivity Of Quantitative Sensory Testing In Patients With Neuropathic Pain

Completed· Pfizer logo

Pfizer·N/A·NCT01117766·31 enrolled

Amitriptyline or Pregabalin to Treat Neuropathic Pain in Incurable Cancer

Unknown status·RRadboud University Medical Center·Phase 3·NCT00740571·130 enrolled

Neuropathic Pain Assessment Comparing Pregabalin and Paroxetine in Management of MS-induced Neuropathic Pain

Completed·UUniversity of Manitoba·Phase 3·NCT00291148·75 enrolled

Pregabalin Versus Placebo In The Treatment Of Neuropathic Pain Associated With HIV Neuropathy

Terminated·PPfizer's Upjohn has merged with Mylan to form Viatris Inc.·Phase 3·NCT01049217·377 enrolled

Evaluation in the Treatment of Neuropathic Pain Post Breast Surgery

Completed·IInstitut Cancerologie de l'Ouest·Phase 3·NCT03794388·140 enrolled

Pregabalin Peripheral Neuropathic Pain Study

Completed·PPfizer's Upjohn has merged with Mylan to form Viatris Inc.·Phase 3·NCT00141219·241 enrolled

Pregabalin20 trials

Perioperative Pregabalin in Ureteroscopy

Completed·UUniversity of Missouri-Columbia·Phase 2/3·NCT04122196·118 enrolled

Effects of Pregabalin, Duloxetine & Amitriptyline on Pain & Sleep

Completed·UUniversity of Surrey·Phase 2/3·NCT00370656·90 enrolled

Effect of Oral Pregabalin on Spinal Neurotransmitters in Patients Undergoing Knee Replacement

Completed·AAsokumar Buvanendran·Phase 3·NCT00729690·48 enrolled

Show 17 more trials

Pregabalin and Colonic Function

Completed·MMayo Clinic·Phase 4·NCT01094808·62 enrolled

PHOTOTHERAPY VERSUS PREGABALIN IN TREATMENT OF REFRACTORY UREAMIC PRURITIS

Unknown status·—·Phase 2·NCT04660773·40 enrolled

Pregabalin in CIPN

Completed·WWashington University School of Medicine·N/A·NCT02394951·26 enrolled

A Post Marketing Surveillance Study On Pregabalin (Lyrica) On Efficacy, Safety And Tolerability Of Pregabalin

Completed·PPfizer's Upjohn has merged with Mylan to form Viatris Inc.··NCT00892008·2,278 enrolled

Pregabalin and Radicular Pain Study (PARPS)

Completed·SSingapore General Hospital·Phase 4·NCT01061697·50 enrolled

The Effect of Gabapentin (Neurentin) and Pregabalin (Lyrica) in Pain Reduction After Photorefractive Keratectomy

Unknown status·SShahid Beheshti University of Medical Sciences·Phase 1·NCT01122004

Behavioral Effects of Pregabalin and Cannabis

Completed·JJoshua A. Lile, Ph.D.·Phase 1·NCT01511640·30 enrolled

Effect Of Pregabalin Treatment In Patients With Diabetic Nerve Pain Who Currently Use A Non-Steroid Anti-Inflammatory Drug (NSAID) For Another Pain

Completed·PPfizer's Upjohn has merged with Mylan to form Viatris Inc.·Phase 3·NCT01455415·306 enrolled

Comparing Efficiency of Mirogabalin and Pregabalin in Primary TKA

Recruiting·TThammasat University Hospital·N/A·NCT06328062·80 enrolled

Pregabalin for the Treatment of Vulvodynia

Terminated·TThe Cleveland Clinic·Phase 2·NCT00853229·16 enrolled

Comparing Pregabalin and Placebo in Patients With Persistent Globus Sensation

Unknown status·UUniversitaire Ziekenhuizen KU Leuven·Phase 4·NCT05432843·90 enrolled

Effect of Pregabalin on Immediate Post-operative and Longterm Pain

Completed·TTurku University Hospital·Phase 4·NCT02464813·64 enrolled

P4 (Pregabalin for Peripheral Posttraumatic Pain)

Completed·PPfizer's Upjohn has merged with Mylan to form Viatris Inc.·Phase 4·NCT00292188·255 enrolled

Pregabalin Treatment for RDEB Pain and Itch

Completed·TThe Hospital for Sick Children·Phase 3·NCT03928093·1 enrolled

A Comparison of Pregabalin (Lyrica®) to Placebo in Pain Relief After Photorefractive Keratectomy (PRK) Surgery

Completed·559th Medical Wing·N/A·NCT01097577·130 enrolled

Efficacy, Safety, Tolerability and Pharmacokinetics of Concomitant Administration of Tramadol With Duloxetine or Pregabalin

Withdrawn·TTurku University Hospital·Phase 4·NCT01116531

The Effect of Pregabalin on Pain of Propofol Injection

Completed·KKyungpook National University Hospital·N/A·NCT02668094·120 enrolled

Peripheral Neuropathy16 trials

A Study In Patients With Neuropathic Pain From Diabetic Peripheral Neuropathy (DPN)

Completed·XXenoPort, Inc.·Phase 2·NCT00643760·421 enrolled

A Long-Term Study To Evaluate Safety And Efficacy Of Pregabalin For Pain Associated With Diabetic Peripheral Neuropathy

Completed·PPfizer's Upjohn has merged with Mylan to form Viatris Inc.·Phase 3·NCT00553280·123 enrolled

The Effect of Pregabalin on Pain Related to Walking in Patients With Diabetic Peripheral Neuropathy

Completed·—·Phase 3·NCT02927951·44 enrolled

Show 13 more trials

Efficacy and Safety Study of Pregabalin in the Treatment of Pain on Walking in Patients With Diabetic Peripheral Neuropathy (DPN)

Completed·PPfizer's Upjohn has merged with Mylan to form Viatris Inc.·Phase 3·NCT01474772·217 enrolled

Evaluation of Efficacy and Safety of VX-993 for Pain Associated With Diabetic Peripheral Neuropathy

Recruiting· Vertex Pharmaceuticals logo

Vertex Pharmaceuticals·Phase 2·NCT06619860·300 enrolled

Evaluation of Efficacy and Safety of VX-548 for Painful Diabetic Peripheral Neuropathy (DPN)

Completed· Vertex Pharmaceuticals logo

Vertex Pharmaceuticals·Phase 2·NCT05660538·194 enrolled

Study To Evaluate Efficacy, Safety And Tolerability Of Lyrica In Patients With Painful Diabetic Peripheral Neuropathy

Completed·PPfizer's Upjohn has merged with Mylan to form Viatris Inc.·Phase 3·NCT01332149·626 enrolled

Safety and Efficacy of Pregabalin in Patients With Diabetic Peripheral Neuropathy.

Completed· Pfizer logo

Pfizer·Phase 3·NCT00141401·240 enrolled

Pregabalin in the Treatment of Pain Due to Diabetic Peripheral Neuropathy

Completed·PPfizer's Upjohn has merged with Mylan to form Viatris Inc.·Phase 4·NCT00159679·167 enrolled

Evaluation of Efficacy and Safety of Suzetrigine for Pain Associated With Diabetic Peripheral Neuropathy

Recruiting· Vertex Pharmaceuticals logo

Vertex Pharmaceuticals·Phase 3·NCT06628908·1,100 enrolled

Study to Assess Analgesic Efficacy and Safety of ASP3662 in Subjects With Painful Diabetic Peripheral Neuropathy

Terminated· Astellas logo

Astellas·Phase 2·NCT02372578·115 enrolled

SPENDD: Quantitative Sensory Testing and Analgesic Response for Painful Peripheral Neuropathy.

Not yet recruiting·UUniversity of Rochester·Phase 2·NCT06614322·190 enrolled

Prevention And Treatment Of Chemotherapy-Induced Peripheral Neuropathy In Subjects With Advanced Colorectal Cancer

Terminated·PPfizer's Upjohn has merged with Mylan to form Viatris Inc.·Phase 4·NCT00380874·64 enrolled

To Evaluate the Safety and Efficacy of Pregabalin in Patients With Painful Diabetic Peripheral Neuropathy.

Completed· Pfizer logo

Pfizer·Phase 3·NCT00150423·384 enrolled

Efficacy and Safety of Gabapentin/B-complex Versus Pregabalin in Diabetic Peripheral Neuropathy Pain Management

Completed· Merck & Co. logo

Merck & Co.·Phase 4·NCT01364298·353 enrolled

Safety of Pregabalin in the Treatment of Pain Due to Diabetic Peripheral Neuropathy

Completed·PPfizer's Upjohn has merged with Mylan to form Viatris Inc.·Phase 4·NCT00159731·160 enrolled

Fibromyalgia16 trials

The Efficacy and Safety of Pregabalin Combined With Toludesvenlafaxine in Patients With Fibromyalgia

Recruiting·—·N/A·NCT07208357·384 enrolled

Treatment of Pain Associated With Fibromyalgia

Completed· Daiichi Sankyo logo

Daiichi Sankyo·Phase 3·NCT02187471·1,301 enrolled

Study Of A Controlled Release Formulation Of Pregabalin In Fibromyalgia Patients

Completed·PPfizer's Upjohn has merged with Mylan to form Viatris Inc.·Phase 3·NCT01271933·441 enrolled

Show 13 more trials

Safety and Efficacy Study of Pregabalin in Fibromyalgia

Completed·PPfizer's Upjohn has merged with Mylan to form Viatris Inc.·Phase 3·NCT00151489·1,020 enrolled

This Study is An Open-Label Trial Of Pregabalin In Patients With Fibromyalgia

Completed·PPfizer's Upjohn has merged with Mylan to form Viatris Inc.·Phase 3·NCT00346034·357 enrolled

Effects Of Pregabalin (Lyrica) On Sleep Maintenance In Subjects With Fibromyalgia

Completed·PPfizer's Upjohn has merged with Mylan to form Viatris Inc.·Phase 3·NCT00883740·119 enrolled

A Phase 3b Multicenter Study of Pregabalin in Fibromyalgia Subjects Who Have Comorbid Depression

Completed·PPfizer's Upjohn has merged with Mylan to form Viatris Inc.·Phase 3·NCT01432236·197 enrolled

An Open-Label Trial of Pregabalin in Patients With Fibromyalgia

Completed·PPfizer's Upjohn has merged with Mylan to form Viatris Inc.·Phase 3·NCT00151528·428 enrolled

Brain Response to Single Dose of Pregabalin in Fibromyalgia

Completed·HHospital de Clinicas de Porto Alegre·Phase 2/3·NCT02639533·27 enrolled

A Study For Pregabalin In Patients With Fibromyalgia

Completed·PPfizer's Upjohn has merged with Mylan to form Viatris Inc.·Phase 3·NCT01387607·343 enrolled

The Effect of Central Sensitization on Treatment Response in Patients With Fibromyalgia

Unknown status·MMarmara University··NCT05020600·40 enrolled

The Efficacy and Safety of Pregabalin Combined With Desvenlafaxine in Patients With Fibromyalgia

Recruiting·—·N/A·NCT07171320·384 enrolled

Special Investigation of Pregabalin for Fibromyalgia (Regulatory Post Marketing Commitment Plan)

Completed·PPfizer's Upjohn has merged with Mylan to form Viatris Inc.··NCT01773993·534 enrolled

Treatment of Pain Associated With Fibromyalgia

Completed· Daiichi Sankyo logo

Daiichi Sankyo·Phase 3·NCT02146430·1,293 enrolled

Pregabalin In Adolescent Patients With Fibromyalgia

Completed·PPfizer's Upjohn has merged with Mylan to form Viatris Inc.·Phase 4·NCT01020526·63 enrolled

The Efficacy and Safety of Pregabalin Combined With Dexmedetomidine in Patients With Fibromyalgia

Recruiting·—·N/A·NCT07230197·400 enrolled

Seizure14 trials

Comparative Study Of Pregabalin And Gabapentin As Adjunctive Therapy In Subjects With Partial Seizures

Completed·PPfizer's Upjohn has merged with Mylan to form Viatris Inc.·Phase 4·NCT00537940·482 enrolled

Pregabalin Versus Levetiracetam In Partial Seizures

Completed·PPfizer's Upjohn has merged with Mylan to form Viatris Inc.·Phase 3·NCT00537238·509 enrolled

To Evaluate Long-Term Safety and Efficacy of Pregabalin in Patients With Partial Seizures.

Completed· Pfizer logo

Pfizer·Phase 3·NCT00141245·325 enrolled

Show 11 more trials

Pregabalin In Partial Seizures (PREPS): An Open-Label, Multicenter Add On Therapy Trial

Terminated·PPfizer's Upjohn has merged with Mylan to form Viatris Inc.·Phase 4·NCT00407797·136 enrolled

Pregabalin In Partial Seizures: An Open-Label, International, Multicenter Add-On Therapy Trial.

Completed·PPfizer's Upjohn has merged with Mylan to form Viatris Inc.·Phase 4·NCT00141427·540 enrolled

A Study of Lyrica as Treatment for Sleep Problems in Patients With Sleep Problems and Seizures

Completed· Pfizer logo

Pfizer·Phase 3·NCT00643136·17 enrolled

Levetiracetam or Pregabalin in Treating Seizures in Patients Undergoing Chemotherapy and/or Radiation Therapy For Primary Brain Tumors

Completed·DDr Andrea Rossetti·Phase 2·NCT00629889·52 enrolled

Evaluation of Long-Term Safety and Efficacy of Pregabalin in Patients With Partial Seizures.

Completed· Pfizer logo

Pfizer·Phase 3·NCT00150293·337 enrolled

Safety, Tolerability, and Pharmacokinetic Study of Pregabalin in Pediatric Patients With Partial Onset Seizures

Completed·PPfizer's Upjohn has merged with Mylan to form Viatris Inc.·Phase 1/2·NCT00437281·65 enrolled

To Evaluate the Long-Term Safety and Efficacy of Pregabalin in Patients With Partial Seizures

Completed· Pfizer logo

Pfizer·Phase 3·NCT00141388·455 enrolled

Lyrica (Pregabalin) Administered as an Add-on Therapy for Partial Seizures (LEADER).

Completed·PPfizer's Upjohn has merged with Mylan to form Viatris Inc.·Phase 4·NCT00288639·98 enrolled

Pregabalin Open-Label Extension Trial in Patients With Partial Seizures

Completed· Pfizer logo

Pfizer·Phase 3·NCT00143143·300 enrolled

Once-A-Day Pregabalin For Partial Seizures

Completed·PPfizer's Upjohn has merged with Mylan to form Viatris Inc.·Phase 3·NCT01262677·325 enrolled

To Evaluate the Long-Term Safety and Efficacy of Pregabalin in Patients With Partial Seizures.

Completed· Pfizer logo

Pfizer·Phase 3·NCT00141336·750 enrolled

80 more indications

Partial Epilepsy4 trials

Systematic Review: Retigabine for Adjunctive Therapy in Partial Epilepsy

Completed· GSK logo

GSK··NCT01587339·6,498 enrolled

To Evaluate the Long-Term Safety of Pregabalin in Refractory Partial Epilepsy.

Completed· Pfizer logo

Pfizer·Phase 2·NCT00141414·82 enrolled

Study Of The Safety And Efficacy Of Lyrica In The Treatment Of Newly Diagnosed Partial Epilepsy

Completed·PPfizer's Upjohn has merged with Mylan to form Viatris Inc.·Phase 3·NCT00280059·660 enrolled

Show 1 more trial

Effect on Anxiety in Partial Epilepsy Patients Treated With Pregabalin

Terminated·NNortheast Regional Epilepsy Group·Phase 4·NCT01128712·4 enrolled

Postherpetic Neuralgia4 trials

Safety And Efficacy Study Of Once Daily Controlled Release Pregabalin In The Treatment Of Patients With Postherpetic Neuralgia

Completed·PPfizer's Upjohn has merged with Mylan to form Viatris Inc.·Phase 3·NCT01270828·806 enrolled

A Long-Term Study To Evaluate Safety And Efficacy Of Pregabalin For Postherpetic Neuralgia

Completed·PPfizer's Upjohn has merged with Mylan to form Viatris Inc.·Phase 3·NCT00424372·126 enrolled

Y-4 to Treat the Postherpetic Neuralgia

Not yet recruiting·NNeurodawn Pharmaceutical Co., Ltd.·Phase 2·NCT07275762·160 enrolled

Show 1 more trial

A 13-Week, Randomized, Double-Blind, Multicenter, Placebo-Controlled Study Of Pregabalin For Postherpetic Neuralgia

Completed·PPfizer's Upjohn has merged with Mylan to form Viatris Inc.·Phase 3·NCT00394901·372 enrolled

Diabetic Neuropathy4 trials

A Randomized Double-Blind Study Testing the Effects of Pregabalin on Diabetic Neuropathy

Completed·—·Phase 4·NCT00573261·40 enrolled

A Study for Treatment of Pain in Patients With Diabetic Neuropathy.

Completed· Eli Lilly logo

Eli Lilly·Phase 2·NCT00785577·273 enrolled

A Study in Painful Diabetic Neuropathy

Completed· Eli Lilly logo

Eli Lilly·Phase 3·NCT01089556·811 enrolled

Show 1 more trial

Evaluation of the Impact of Training on Outcome Measures in Subjects With Painful Diabetic Neuropathy

Unknown status·AAnalgesic Solutions·Phase 4·NCT01770964·90 enrolled

Generalized Anxiety Disorder4 trials

Safety and Efficacy Evaluation Of Pregabalin (Lyrica) With Patients With Generalized Anxiety Disorder

Completed·PPfizer's Upjohn has merged with Mylan to form Viatris Inc.·Phase 4·NCT00624780·615 enrolled

Pregabalin in the Treatment of Patients With Generalized Anxiety Disorder (GAD).

Completed·PPfizer's Upjohn has merged with Mylan to form Viatris Inc.·Phase 3·NCT00413010·356 enrolled

Comparison of Pregabalin Versus Venlafaxine XR and Placebo in the Treatment of Generalized Anxiety Disorder

Completed·PPfizer's Upjohn has merged with Mylan to form Viatris Inc.·Phase 3·NCT00151450·390 enrolled

Show 1 more trial

Efficacy and Safety of Pregabalin vs Placebo for Generalized Anxiety Disorder (GAD) Symptoms in Subjects Discontinuing Benzodiazepine Treatment and Remaining 6 Weeks on Study Medication, Free From Benzodiazepine Use.

Completed·PPfizer's Upjohn has merged with Mylan to form Viatris Inc.·Phase 3·NCT00368745·108 enrolled

Chronic pain3 trials

Chronic Pain Management After Herniorraphy

Completed·EErasmus Medical Center·Phase 3·NCT00772291·140 enrolled

Cebranopadol Efficacy and Safety in Diabetic Patients Suffering From Chronic Pain Caused by Damage to the Nerves

Completed·TTris Pharma, Inc.·Phase 2·NCT01939366·699 enrolled

Comparison of Oral Lamotrigine Versus Pregabalin for Control of Acute and Chronic Pain

Available·—··NCT03419949

Breast Cancer3 trials

Swiss Multi-centre, Randomized, Placebo Controlled Trial of Pregabalin for Prevention of Persistent Pain in High Risk Patients Undergoing Breast Cancer Surgery

Terminated·BBenno Rehberg-Klug·Phase 3·NCT03216187·126 enrolled

The Efficacy of Tianeptine Versus Pregabalin on Acute and Chronic Post Mastectomy Pain After Breast Cancer Surgery.

Completed·NNational Cancer Institute, Egypt·N/A·NCT05935059·90 enrolled

The Effects of Peri-Operative Pregabalin on Post-Operative Pain Following Breast Cancer Surgery With Axillary Node Dissection: A Pilot Study

Completed·NNova Scotia Health Authority·Phase 3·NCT00852683·70 enrolled

Analgesic3 trials

Assessment of the Analgesic Effects of PF-06273340 in Healthy Volunteers Using Evoked Pain Endpoints

Completed· Pfizer logo

Pfizer·Phase 1·NCT02260947·20 enrolled

Assessment of the Analgesic Effects of PF-06372865 in Healthy Volunteers Using Evoked Pain Endpoints

Completed· Pfizer logo

Pfizer·Phase 1·NCT02238717·20 enrolled

MAST Trial: Multi-modal Analgesic Strategies in Trauma

Completed·TThe University of Texas Health Science Center, Houston·Phase 4·NCT03472469·1,561 enrolled

Spinal Cord Injury3 trials

A 17-Week Trial To Assess Pregabalin For The Treatment Of Nerve Pain Due To Spinal Cord Injury

Completed·PPfizer's Upjohn has merged with Mylan to form Viatris Inc.·Phase 3·NCT00407745·220 enrolled

Pregabalin for the Treatment and Prevention of Spinal Cord Injury Neuropathic Pain

Unknown status·JJulian Taylor Green·Phase 4·NCT01479556·82 enrolled

To Evaluate Long-Term Safety and Efficacy of Pregabalin in the Treatment of Neuropathic Pain After Spinal Cord Injury.

Completed· Pfizer logo

Pfizer·Phase 3·NCT00141375·132 enrolled

Neuralgia3 trials

Efficacy of Pregabalin for the Treatment of Acute Herpetic Neuralgia

Completed·—·Phase 4·NCT03809702·82 enrolled

Study of Pregabalin Therapy for Pain Relief in Subjects With Post-Herpetic Neuralgia

Completed·PPfizer's Upjohn has merged with Mylan to form Viatris Inc.·Phase 4·NCT00159666·255 enrolled

A Study To Compare Pregabalin/PF-00489791 Combination Versus Pregabalin Alone In Post-Herpetic Neuralgia

Completed· Pfizer logo

Pfizer·Phase 2·NCT00599638·72 enrolled

Bone pain2 trials

A Study To Evaluate Pregabalin In The Treatment Of Moderate To Severe Chronic Bone Pain Related To Metastatic Cancer

Terminated·PPfizer's Upjohn has merged with Mylan to form Viatris Inc.·Phase 4·NCT00381095·152 enrolled

Trial of Pregabalin for Granulocyte Colony-stimulating Factor (GCSF)-Induced Bone Pain

Terminated·UUNC Lineberger Comprehensive Cancer Center·Phase 2·NCT03407430·11 enrolled

Inguinal hernia2 trials

Surgical Pain After Inguinal Hernia Repair (SPAIHR)

Completed·PPfizer's Upjohn has merged with Mylan to form Viatris Inc.·Phase 3·NCT00551135·425 enrolled

Efficacy of Pre-operative Oral Pregabalin in Ambulatory Inguinal Hernia Repair for Post Operative Pain

Unknown status·UUniversity of Malaya·Phase 3·NCT01450345·72 enrolled

Preoperative2 trials

Analgetic Effect of Preoperative Pregabalin in Patients Undergoing Nephrectomy

Completed·MMedical University of Graz·Phase 3·NCT00957177·20 enrolled

Effect of Preoperative Pregabalin on Propofol Induction Dose

Completed·UUniversité de Sherbrooke·Phase 4·NCT01158859·50 enrolled

Mastectomy2 trials

Adding Amantadine or Duloxetine to Pregabalin on Occurrence of Post Mastectomy Pain Syndrome

Recruiting·—·N/A·NCT07421427·150 enrolled

Perioperative Administration of Pregabalin for Pain After Mastectomy

Completed·SSeverance Hospital·Phase 4·NCT00938548·70 enrolled

Irritable Bowel Syndrome2 trials

Pregabalin on Colonic Motor and Sensory Function in Constipation Predominant Irritable Bowel Syndrome

Completed·MMayo Clinic·Phase 4·NCT01331213·18 enrolled

A Placebo-Controlled Trial of Pregabalin (Lyrica) for Irritable Bowel Syndrome

Completed·MMayo Clinic·Phase 2·NCT00977197·85 enrolled

Post-craniotomy2 trials

Pregabalin for Post-craniotomy Pain Control

Unknown status·TTel-Aviv Sourasky Medical Center·N/A·NCT01612832·100 enrolled

Effects of Perioperative Pregabalin for Post-Craniotomy Pain

Withdrawn·UUnity Health Toronto·Phase 4·NCT01591980

Restless Legs Syndrome2 trials

Lyrica Dose Response Study With Restless Legs Syndrome (RLS) Patients

Completed·PPfizer's Upjohn has merged with Mylan to form Viatris Inc.·Phase 2·NCT00676403·137 enrolled

Polysomnography Study Of Pregabalin And Pramipexole Versus Placebo In Patients With Restless Legs Syndrome And Associated Sleep Disturbance

Completed·PPfizer's Upjohn has merged with Mylan to form Viatris Inc.·Phase 3·NCT00991276·85 enrolled

Post Operative Pain2 trials

Safety and Efficacy of Pre-emptive Tapentadol vs Pregabalin in Post Operative Pain Following Surgery

Completed·—·Phase 4·NCT03604354·95 enrolled

Pre- Versus Post-incisional Pregabalin for Postoperative Pain Attenuation and Analgesics Spare in Orthopedic Oncologic Patients

Unknown status·TTel-Aviv Sourasky Medical Center·N/A·NCT01359059·80 enrolled

Randomized Controlled Trial1 trial

Prospective, Randomized Controlled Trial on Perioperative Pregabalin to Reduce Late-onset CRPS After TKA

Completed·RRush University Medical Center·Phase 2·NCT00558753·240 enrolled

Sedation1 trial

Melatonin vs Pregabalin for Anxiolysis and Sedation

Completed·MMenoufia University·Phase 4·NCT05221151·78 enrolled

Hysterectomy1 trial

Effect of Pregabalin on Post Operative Pain in Abdominal Hysterectomy Under Spinal Anesthesia With Intrathecal Morphine

Completed·MMahidol University·Phase 4·NCT02285010·125 enrolled

Post-thoracotomy Pain1 trial

Adding Amantadine to Pregabalin on Occurrence of Post-thoracotomy Pain Syndrome

Completed·—·N/A·NCT06833203·60 enrolled

Acetaminophen1 trial

A Phase 2 Study to Evaluate Pregabalin and Acetaminophen Compared to Acetaminophen and Placebo in Subjects Undergoing Bunionectomy

Completed·NNevakar, Inc.·Phase 2·NCT04495283·87 enrolled

Anterior Cruciate Ligament Reconstruction1 trial

Perioperative Administration of Pregabalin in Patients Undergoing Arthroscopic Anterior Cruciate Ligament Reconstruction

Completed·PPrince of Songkla University·Phase 4·NCT01242332·60 enrolled

Anxiety1 trial

Perioperative Pregabalin Use, Rehabilitation, Pain Outcomes and Anxiety Following Hip Surgery

Unknown status·SSunnybrook Health Sciences Centre·Phase 4·NCT00762099·184 enrolled

Head and Neck Cancer1 trial

Interest of Pregabalin (Lyrica) on the Treatment of Reflex Earache in Head and Neck Cancer.

Terminated·UUniversity Hospital, Lille·Phase 2·NCT02924675·42 enrolled

Prevention1 trial

Pain Prevention and Treatment Through the Enhancement of the Anti-nociceptive Component of Pain Modulation Profiles

Completed·RRambam Health Care Campus·N/A·NCT02020122·5 enrolled

Randomized1 trial

Randomized, Open-label, Parallel Study to Evaluate the Pharmacokinetic Characteristics of Pregabalin According to Different Controlled Released Formulations in Healthy Male Subjects

Completed·YYuhan Corporation·Phase 1·NCT01420913·28 enrolled

Muscle Cramp1 trial

A Study Evaluating the Efficacy and Safety of Pregabalin Against Frequent Muscle Cramp in Patients With Liver Cirrhosis

Completed·SSeoul National University Boramae Hospital·Phase 3·NCT01271660·60 enrolled

Essential Tremor1 trial

Pregabalin (Lyrica) for the Treatment of Essential Tremor

Completed·UUniversity of South Florida·Phase 4·NCT00584376·29 enrolled

Surgery1 trial

Preventing Pain After Heart Surgery

Completed·BBarts & The London NHS Trust·Phase 4·NCT01480765·150 enrolled

Paclitaxel1 trial

Pregabalin in Preventing Acute Pain Syndrome in Patients Receiving Paclitaxel

Completed·—·Phase 2·NCT01637077·46 enrolled

Interaction1 trial

Drug-Drug Interaction Study of "CG-651" in Healthy Volunteer

Completed·CCrystalGenomics, Inc.·Phase 1·NCT05370716·47 enrolled

Terminated·VVA Office of Research and Development·Phase 2·NCT01846182·112 enrolled

Dexamethasone1 trial

Effect of Paracetamol, Pregabalin and Dexamethasone on Pain and Opioid Requirements in Patients After Hip Operations

Completed·GGlostrup University Hospital, Copenhagen·Phase 4·NCT00235261·120 enrolled

Sleep Disorder1 trial

Improving Perioperative Sleep Disorders

Completed·MMengchang Yang·Phase 1·NCT06512155·215 enrolled

Dexmedetomidine1 trial

The Effect of Dexmedetomidine, Melatonin and Pregabalin

Unknown status·EEgymedicalpedia·Phase 1·NCT05829148·120 enrolled

Chronic Cough1 trial

A 2x2 Factorial, Randomized, Open-label Trial to Evaluate Neuromodulators and Cough Control Therapy in Patients With Refractory or Unexplained Chronic Cough

Not yet recruiting·MMcMaster University·Phase 4·NCT07288528·124 enrolled

Pruritus1 trial

Efficacy of Pregabalin in the Management of Chronic Uremic Pruritus

Unknown status·SShaare Zedek Medical Center·Phase 4·NCT01073501·36 enrolled

Schizophrenia1 trial

Pregablin for Anxiety-comorbidity in Patients With Schizophrenia

Completed·UUniversity of Aarhus·Phase 4·NCT01496690·54 enrolled

Coronary Artery Bypass1 trial

Pregabalin Versus Dexmedetomidine for Delirium Treatment After Coronary Artery Bypass Grafting

Recruiting·TTanta University·Phase 4·NCT05640453·70 enrolled

Chronic Fatigue Syndrome1 trial

Investigation of Treating Chronic Fatigue Syndrome After COVID With Pharmacotherapy (Pregabalin) or Complex Rehabilitation

Recruiting·NNational Institute of Geriatrics, Rheumatology and Rehabilitation, Poland·Phase 2·NCT05967052·132 enrolled

Hypotensive Anesthesia1 trial

Pregabalin Effects on Hypotensive Anesthesia During Spine Surgery.

Completed·MMansoura University·N/A·NCT03301025·106 enrolled

Neuropathy1 trial

Evaluation of Pregabalin in Idiopathic Small Fiber Neuropathy

Terminated·UUniversity of Alberta·N/A·NCT00787462·3 enrolled

Abortion1 trial

Prophylactic Pregabalin to Decrease Pain During Medical Abortion

Completed·UUniversity of Hawaii·Phase 4·NCT02782169·110 enrolled

Cognitive Function1 trial

Efficacy of Pregabalin and Duloxetine in Patients With PDPN: the Effect of Pain on Cognitive Function, Sleep and Quality of Life

Terminated·KKRKA·Phase 4·NCT04246619·254 enrolled

Dementia1 trial

Pain in Patients With Dementia and Behavioural Disturbances

Completed·UUniversity of Bergen·Phase 2/3·NCT01021696·352 enrolled

Ischemia1 trial

Randomized Study of Pregabalin for Pain Reduction in Patients With Rest Pain and Lower Limb Ischemia

Terminated·KKarolinska Institutet·Phase 4·NCT00403780·18 enrolled

Dry Eye Symptoms1 trial

Can Pregabalin Reduce the Frequency and Severity of Dry Eye Symptoms After Laser-assisted in Situ Keratomileusis?

Completed·UUniversity of Miami·Phase 2/3·NCT02701764·43 enrolled

Alcohol Use Disorder1 trial

Pregabalin as Treatment for Alcohol Use Disorder

Completed·NNew York State Psychiatric Institute·Phase 2·NCT03256253·18 enrolled

Postoperative Analgesia1 trial

Postoperative Analgesia After Laparoscopic Living Donor Nephrectomy

Completed·OOslo University Hospital·Phase 4·NCT01059331·80 enrolled

Chronic Prostatitis1 trial

Efficacy & Safety Study of Pregabalin to Treat Chronic Prostatitis/Chronic Pelvic Pain Syndrome (CP/CPPS)

Completed·NNational Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)·Phase 3·NCT00371033·324 enrolled

Epilepsy1 trial

Pregabalin Epilepsy Add-On Trial

Completed·PPfizer's Upjohn has merged with Mylan to form Viatris Inc.·Phase 3·NCT00141258·178 enrolled

Osteoarthritis1 trial

Comparison of the Efficacy of Duloxetine and Pregabalin in Patients With Knee Osteoarthritis With Mix Type Pain

Completed·FFatih Sultan Mehmet Training and Research Hospital·Phase 4·NCT04532684·66 enrolled

Nausea and vomiting1 trial

Pregabalin for the Prevention of Chemotherapy Induced Nausea and Vomiting

Unknown status·FFaculdade de Medicina do ABC·Phase 2·NCT04181346·82 enrolled

Opioid Use Disorder1 trial

PROUD Study - Preventing Opioid Use Disorders

Terminated·EEmory University·Phase 4·NCT04766996·57 enrolled

Medication1 trial

The Effects of GABA Enhancing Medications on Individuals Addicted to Cocaine - 3

Terminated·YYale University·N/A·NCT00142883·72 enrolled

Hot flashes1 trial

Pregabalin in Treating Women With Hot Flashes

Completed·AAlliance for Clinical Trials in Oncology·Phase 3·NCT00702949·207 enrolled

Effectiveness1 trial

Effectiveness of Two Different Doses of BI 1026706 on the Overall Peak-to-Peak (PtP) N2/P2-component Amplitude of Laser (Somatosensory, Radiant-heat) Evoked Potentials (LEP) in UVB(Ultraviolet)-Irradiated Skin in Healthy Male Volunteers

Completed· Boehringer Ingelheim logo

Boehringer Ingelheim·Phase 1·NCT02037165·25 enrolled

After Cardiac Surgery1 trial

The Effects of Pregabalin on Postoperative Pain After Cardiac Surgery

Completed·LLarissa University Hospital·Phase 2/3·NCT01701921·94 enrolled

Outcome1 trial

Lumbar Stenosis Outcomes Research (LUSTOR)

Completed·UUniversity of Rochester·Phase 4·NCT00638443·29 enrolled

Sevoflurane1 trial

Pregabalin Reduce the Sevoflurane Requirement

Completed·MMansoura University·Phase 2·NCT01571804·42 enrolled

Bunion1 trial

Bunionectomy Study (0000-063)

Completed· Merck & Co. logo

Merck & Co.·Phase 1·NCT00601458·100 enrolled

Delirium1 trial

Pregabalin in the Prevention of Postoperative Delirium and Pain

Completed·OOttawa Hospital Research Institute·Phase 3·NCT00819988·240 enrolled

Postoperative Pain Control1 trial

Comparison of Oral Gabapentin and Pregabalin in Postoperative Pain Control After Photorefractive Keratectomy

Terminated·LLoma Linda University·N/A·NCT00954187·8 enrolled

Anxiolytic Effect1 trial

Analgetic and Anxiolytic Effect of Preoperative Pregabalin

Completed·—·Phase 4·NCT00353704·50 enrolled

Total Knee Arthroplasty1 trial

Outcomes Of Perioperative Pregabalin On Total Knee Arthroplasty

Completed·NNational University Hospital, Singapore·Phase 3·NCT02954484·116 enrolled

Herpes Zoster1 trial

Comparative Efficacy of Pregabalin and Lacosamide in Patients With Herpes Zoster and Post Herpetic Neuralgia

Recruiting·—·N/A·NCT06969417·50 enrolled

Drug Therapy1 trial

Effect of Preventional Drug Therapy on Pain Regulation Mechanisms Among SCI

Unknown status·SSheba Medical Center·Phase 4·NCT03748290·50 enrolled

Pain Control1 trial

Study Evaluating the Effects of Toradol and Lyrica for Pain Control After Donor Nephrectomy

Completed·UUniversity of Utah·Phase 2·NCT03669081·64 enrolled

Total Knee Replacement1 trial

Efficacy And Safety Of Pregabalin For Pain Following Total Knee Replacement

Completed·PPfizer's Upjohn has merged with Mylan to form Viatris Inc.·Phase 3·NCT00442546·307 enrolled

Cardiovascular1 trial

Pregabalin Stabilize Cardiovascular Response to Intubation

Completed·SShanghai Zhongshan Hospital·Phase 4·NCT03456947·90 enrolled

Migraine1 trial

Efficacy of Pregabalin in Migraine Prevention

Withdrawn·—·Phase 3·NCT00447369·70 enrolled

Complex Regional Pain Syndrome1 trial

Pregabalin Versus Placebo as an Add on for Complex Regional Pain Syndrome (CPRS) of the Upper Limb Managed by Stellate Ganglion Block (The PREGA Study)

Terminated·MMcMaster University·N/A·NCT00891397·14 enrolled

Interscalene Brachial Plexus Block1 trial

Pain Relief Following Arthroscopic Rotator Cuff Repair: Perioperative Pregabalin Administration Versus Interscalene Brachial Plexus Block

Unknown status·TTel-Aviv Sourasky Medical Center·N/A·NCT01359085·56 enrolled

Clinical Trial1 trial

A Clinical Trial to Compare The Pharmacokinetics of A Pregabalin GLARS Tablet 150mg With Immediate Release Formulation and to Assess The Effect of High Fat Diet in Healthy Male Subjects

Completed·GGL Pharm Tech Corporation·Phase 1·NCT01635751·30 enrolled

Remifentanil1 trial

Pregabalin and Remifentanil - Analgesia and Ventilation

Completed·OOslo University Hospital·Phase 4·NCT01419405·12 enrolled

Unspecified3 trials

Study to Investigate the Pharmacodynamic Effects of IP2015 in Healthy Male Subjects Using the Intradermal Capsaicin Model

Unknown status·IInitiator Pharma·Phase 1·NCT05181852·24 enrolled

Evaluation Of Sperm Production With Healthy Male Volunteers Receiving Lyrica Or Placebo

Completed·PPfizer's Upjohn has merged with Mylan to form Viatris Inc.·Phase 4·NCT00631696·222 enrolled

Pharmacovigilance in Gerontopsychiatric Patients

Terminated·HHannover Medical School·Phase 3·NCT02374567·407 enrolled

Regulatory

FDA Approval Timeline[5]

Dec 30, 2004

LYRICA

NDA NDA021446

Jan 4, 2010

LYRICA

NDA NDA022488

Oct 11, 2017

LYRICA CR

NDA NDA209501

Sources

References

[1]
ClinicalTrials.gov — 415 trial records for Pregabalin. U.S. National Library of Medicine, National Institutes of Health.
[2]
MedlinePlus Drug Information — Lyrica drug information. U.S. National Library of Medicine, National Institutes of Health.
[3]
ChEMBL — Pregabalin compound record. European Bioinformatics Institute (EMBL-EBI).
[4]
Open Targets Platform — Drug–disease associations for Pregabalin. EMBL-EBI & Wellcome Sanger Institute.
[5]
OpenFDA — FDA approval records (NDA NDA209501). U.S. Food & Drug Administration.
[6]
FDA Orange Book — Patent and exclusivity data for Lyrica. U.S. Food & Drug Administration.
[7]
SEC EDGAR — Pfizer's Upjohn has merged with Mylan to form Viatris Inc. company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Mechanism of Action: Voltage-Gated Calcium Channel Modulator[3]
Modality: Small molecule[3]
Highest Phase: Approved[1]
Company: PPfizer's Upjohn has merged with Mylan to form Viatris Inc.

Patent Landscape[6]

Patent Cliff

Nov 2, 2026

Earliest patent expiration — generic entry possible after this date

Patent #Expires

10022447Nov 2, 2026

8945620Nov 2, 2026

9144559Nov 2, 2026

9144559*PEDMay 2, 2027

10022447*PEDMay 2, 2027

1 more patents

8945620*PEDMay 2, 2027

Lyrica

Status by Indication[4][1]

Competitive Landscape

Expected Milestones

Q4 2026

Q1 2027

Q2 2027

Trials by Indication[1]

Neuropathic Pain22 trials

Pregabalin20 trials

Peripheral Neuropathy16 trials

Fibromyalgia16 trials

Seizure14 trials

Partial Epilepsy4 trials

Postherpetic Neuralgia4 trials

Diabetic Neuropathy4 trials

Generalized Anxiety Disorder4 trials

Chronic pain3 trials

Breast Cancer3 trials

Analgesic3 trials

Spinal Cord Injury3 trials

Neuralgia3 trials

Bone pain2 trials

Inguinal hernia2 trials

Preoperative2 trials

Mastectomy2 trials

Irritable Bowel Syndrome2 trials

Post-craniotomy2 trials

Restless Legs Syndrome2 trials

Post Operative Pain2 trials

Randomized Controlled Trial1 trial

Sedation1 trial

Hysterectomy1 trial

Post-thoracotomy Pain1 trial

Acetaminophen1 trial

Anterior Cruciate Ligament Reconstruction1 trial

Anxiety1 trial

Head and Neck Cancer1 trial

Prevention1 trial

Randomized1 trial

Muscle Cramp1 trial

Essential Tremor1 trial

Surgery1 trial

Paclitaxel1 trial

Interaction1 trial

Low back pain1 trial

Arterial Occlusive Disease1 trial

Withdrawal Syndrome1 trial

Gulf War Illness1 trial

Dexamethasone1 trial

Sleep Disorder1 trial

Dexmedetomidine1 trial

Chronic Cough1 trial

Pruritus1 trial

Schizophrenia1 trial

Coronary Artery Bypass1 trial

Chronic Fatigue Syndrome1 trial

Hypotensive Anesthesia1 trial

Neuropathy1 trial

Abortion1 trial

Cognitive Function1 trial

Dementia1 trial

Ischemia1 trial

Dry Eye Symptoms1 trial

Alcohol Use Disorder1 trial

Postoperative Analgesia1 trial

Chronic Prostatitis1 trial

Epilepsy1 trial

Osteoarthritis1 trial

Nausea and vomiting1 trial

Opioid Use Disorder1 trial

Medication1 trial

Hot flashes1 trial

Effectiveness1 trial

After Cardiac Surgery1 trial

Outcome1 trial

Sevoflurane1 trial

Bunion1 trial

Delirium1 trial

Postoperative Pain Control1 trial