hydromorphone hydrochloride

Phase 3Small molecule

PPurdue Pharma LP

hydromorphone hydrochloride is one of 54 small molecule programs targeting Rib Fracture. It is currently in Phase 3.

Indications

Total Trials

Active Trials

Competitors

Pipeline

Status by Indication[3][1]

Indication

Rib FractureActive, not recruiting

Liver and Intrahepatic Bile Duct DisorderActive, not recruiting

Cardiac SurgeryUnknown status

Cancer PainRecruiting

Rib FracturePreclinical

Active, not recruiting

Liver and Intrahepatic Bile Duct DisorderPhase 3

Active, not recruiting

Cardiac SurgeryPreclinical

Unknown status

Cancer PainPhase 3

Recruiting

Competition

Competitive Landscape

30 competitors in Cardiac Surgery

#DrugCompanyPhaseTrials

Farxiga

AstraZeneca

Approved

2 2

Vancocin

HHikma Pharmaceuticals LLC

Approved

5 3

Ancef

BBaxter Healthcare Corporation

Approved

3 4

Pitressin

AAultman Health Foundation

Approved

2 5

Naropin

FFresenius Kabi USA, LLC

Approved

1 6

Neo-Synephrine

EExela Pharma Sciences, LLC.

Approved

1 7

Bridion

CCidara Therapeutics Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)

Phase 3

2 8

Dolophine

HHikma Pharmaceuticals LLC

Phase 3

2 9

Oruvail

WWyeth-Lederle Vaccines

Phase 3

1 10

Acanya

Pfizer

Phase 2

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q3 2027

Phase 3Active, not recruiting

Liver and Intrahepatic Bile Duct Disorder

NCT03214510

Q4 2028

Phase 1Recruiting

Cancer Pain

NCT07489625

Clinical

Trials by Indication[1]

Cancer Pain2 trials

IV PCA With or Without Continuous Dose vs Oral Opioid to Maintain Analgesia for Severe Cancer Pain After Successful Titration

Completed·FFujian Cancer Hospital·Phase 3·NCT04785768·1,372 enrolled

Observation on the Clinical Efficacy of Hydromorphone Hydrochloride Sustained-Release Tablets Combined With Electroacupuncture and Ear Acupoint Pressing Beans in the Treatment of Refractory Cancer Pain

Recruiting·QQinghai Red Cross Hospital·Phase 1·NCT07489625·30 enrolled

Perioperative Analgesia1 trial

Hydromorphone for Perioperative Analgesia in Lung Tumor Ablation Parallel Controlled

Unknown status·QQianfoshan Hospital·Phase 4·NCT05848635·88 enrolled

Effectiveness1 trial

The Evaluation of the Effectiveness and Safety of Nalbuphine Hydrochloride Injection for Analgesia in ICU Patients: A Multicenter, Randomized, Single-blinded, Parallel, Two-step Trial

Recruiting·UUnion Hospital, Tongji Medical College, Huazhong University of Science and Technology·Phase 2/3·NCT06785571·204 enrolled

Patient-Controlled Analgesia1 trial

Epidural Analgesia or Patient-Controlled Analgesia in Treating Patients Who Have Undergone Surgery for Gynecologic Cancer

Completed·UUniversity of California, San Francisco··NCT00295945·240 enrolled

Efficacy and Safety1 trial

Efficacy and Safety of Hydromorphone Hydrochloride Extended-Release Compared to Placebo in Subjects With Persistent Pain

Terminated·PPurdue Pharma LP·Phase 3·NCT00365898·380 enrolled

9 more indications

ESS1 trial

Single-arm Study to Assess the Safety of Hydromorphone Hydrochloride by Intrathecal Administration

Completed·PPiramal Critical Care, Ltd.·Phase 3·NCT01709747·364 enrolled

Rib Fracture1 trial

Continuous Intercostal Nerve Blockade for Traumatic Rib Fractures

Terminated·AAnthony Iacco·N/A·NCT02604589·10 enrolled

Cardiac Surgery1 trial

Analgesic Effects of Transversus Thoracic Plane (TTP) Block in Cardiac Surgery

Unknown status·WWestern University, Canada·N/A·NCT03128346·100 enrolled

Intravenous1 trial

Compare Fentanyl Nasal Spray With Intravenous Opioids to Treat Severe Pain

Completed·MM.D. Anderson Cancer Center·Phase 4·NCT02459964·84 enrolled

Colorectal Surgery1 trial

Outcomes of Intrathecal Analgesia in Colorectal Surgery

Completed·MMayo Clinic··NCT03411109·601 enrolled

Prostate Cancer1 trial

Epidural Hydromorphone Compared With Hydromorphone Infusion in Treating Patients With Prostate Cancer Undergoing Radical Prostatectomy

Completed·RRoswell Park Cancer Institute·Phase 3·NCT00003115·40 enrolled

Safety and Efficacy1 trial

Safety and Efficacy Study of Hydromorphone Hydrochloride by Intrathecal Administration

Completed·PPiramal Critical Care, Ltd.·Phase 3·NCT01709721·153 enrolled

Liver and Intrahepatic Bile Duct Disorder1 trial

Randomized, Unblinded, Phase III Trial of Thoracic Epidural Analgesia Versus Four-Quadrant Transversus Abdominus Plane Block in Oncologic Open-Incision Liver Surgery

Active, not recruiting·MM.D. Anderson Cancer Center·Phase 3·NCT03214510·101 enrolled

Unspecified2 trials

Fasting Study of Hydromorphone Hydrochloride 8 mg Tablets and Dilaudid 8 mg Tablets

Completed·MMallinckrodt·Phase 1·NCT00853554·24 enrolled

Generation of Biological Samples Positive to Hydromorphone for Anti-doping Control

Completed·PParc de Salut Mar·Phase 1·NCT04081376·2 enrolled

Sources

References

[1]
ClinicalTrials.gov — 16 trial records for hydromorphone hydrochloride. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — hydromorphone hydrochloride compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for hydromorphone hydrochloride. EMBL-EBI & Wellcome Sanger Institute.
[4]
SEC EDGAR — Purdue Pharma LP company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[2]
Highest Phase: Phase 3[1]
Company: PPurdue Pharma LP

hydromorphone hydrochloride

Status by Indication[3][1]

Competitive Landscape

Expected Milestones

Q3 2027

Q4 2028

Trials by Indication[1]

Cancer Pain2 trials

Perioperative Analgesia1 trial

Effectiveness1 trial

Patient-Controlled Analgesia1 trial

Efficacy and Safety1 trial

ESS1 trial

Rib Fracture1 trial

Cardiac Surgery1 trial

Intravenous1 trial

Colorectal Surgery1 trial

Prostate Cancer1 trial

Safety and Efficacy1 trial

Liver and Intrahepatic Bile Duct Disorder1 trial

Unspecified2 trials

References

Drug Info

Quick Facts

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