Intravitreal injection of Avastin

Phase 1Small molecule

SShahid Beheshti University of Medical Sciences

Intravitreal injection of Avastin is one of 102 small molecule programs targeting Choroidal Neovascularization. It is currently in Phase 1.

Indications

Total Trials

Active Trials

101

Competitors

Pipeline

Status by Indication[3][1]

Indication

Choroidal NeovascularizationActive, not recruiting

Proliferative Diabetic RetinopathyActive, not recruiting

Cystoid Macular EdemaActive, not recruiting

RetinopathyActive, not recruiting

Retinal Vein OcclusionActive, not recruiting

Diabetic Macular EdemaActive, not recruiting

Choroidal NeovascularizationPhase 2/Phase 3

Active, not recruiting

Proliferative Diabetic RetinopathyPhase 2/Phase 3

Active, not recruiting

Cystoid Macular EdemaPhase 1

Active, not recruiting

RetinopathyPhase 2/Phase 3

Active, not recruiting

Retinal Vein OcclusionPhase 2/Phase 3

Active, not recruiting

Diabetic Macular EdemaPhase 2/Phase 3

Active, not recruiting

Competition

Competitive Landscape

180 competitors in Diabetic Macular Edema

#DrugCompanyPhaseTrials

Eylea

Regeneron

Phase 3

54 2

Lucentis

Roche

Phase 3

59 3

Avastin

BBio-Thera Solutions

Phase 3

23 4

Beovu

Novartis

Phase 3

6 5

Kenalog

BBausch Health Americas, Inc.

Phase 3

14 6

Synalar

EEurofarma Laboratorios S.A.

Phase 3

4 7

Lucentis

Novartis

Phase 3

8 8

Luye Pharma Conbercept

CChengdu Kanghong Biotech Co., Ltd.

Phase 3

3 9

Intravitreal Ranibizumab

Roche

Phase 3

4 10

Glucophage

EMD Serono

Phase 3

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Clinical

Trials by Indication[1]

Retinal Vein Occlusion2 trials

Comparison of Combined Intravitreal Bevacizumab and Oral Acetazolamide Versus Intravitreal Bevacizumab Alone for the Treatment of Macular Edema Secondary to Retinal Vein Occlusions

Unknown status·SShahid Beheshti University of Medical Sciences·Phase 2·NCT05290948·57 enrolled

Comparison of Therapeutic Effects Between Intravitreal Injection of Bevacizumab With Intravitreal Injection of Bevacizumab and Targeted Laser Photocoagulation of Non Perfused Areas of Retina in Patients With Acute Retinal Vein Occlusion

Unknown status·SShahid Beheshti University of Medical Sciences·Phase 2/3·NCT03353324·74 enrolled

Proliferative Diabetic Retinopathy2 trials

Intravitreal Bevacizumab vs Photocoagulation for Proliferative Diabetic Retinopathy

Withdrawn·AAsociación para Evitar la Ceguera en México·Phase 2/3·NCT00347698

Intravitreal Bevacizumab for Proliferative Diabetic Retinopathy

Completed·KKhon Kaen University·Phase 4·NCT01724385·18 enrolled

Bevacizumab2 trials

Efficacy of Retreatments With Intravitreal Bevacizumab

Terminated·AAsociación para Evitar la Ceguera en México·Phase 3·NCT00406744·20 enrolled

Intravitreal Bevacizumab for Idiopathic Macular Telangiectasia

Completed·UUniversity of Sao Paulo·Phase 3·NCT00451763·31 enrolled

Diabetic Macular Edema2 trials

Additional Effect of Subthreshold Micropulse Laser to Intravitreous Injection of Bevacizumab on Diabetic Macular Edema

Unknown status·SShahid Beheshti University of Medical Sciences·Phase 2/3·NCT05582577·30 enrolled

Combined Intravitreal Fasudil and Bevacizumab for Diabetic Macular Edema

Completed·SShahid Beheshti University of Medical Sciences·Phase 3·NCT01823081·74 enrolled

Retinopathy1 trial

Intravitreal Bevacizumab for the Treatment of Central Serous Chorioretinopathy

Withdrawn·AAsociación para Evitar la Ceguera en México·Phase 2/3·NCT00418431

4 more indications

Macular Edema1 trial

Bevacizumab Versus Ranibizumab in Treatment of Macular Edema From Vein Occlusion

Completed·BBarnes Retina Institute·N/A·NCT01428388·150 enrolled

Choroidal Neovascularization1 trial

Comparative Study With Photodynamic Therapy And Triamcinolone Versus Photodynamic Therapy, Triamcinolone And Ranibizumab In Patients With Subfoveal Choroidal Neovascularization

Withdrawn·AAsociación para Evitar la Ceguera en México·Phase 2/3·NCT00930189

Cystoid Macular Edema1 trial

To Compare Therapeutic Effect of Intravitreal Bevacizumab and Triamcinolone in Resistant Uveitic Cystoid Macular Edema

Unknown status·SShahid Beheshti University of Medical Sciences·Phase 1·NCT00371111·40 enrolled

Unspecified1 trial

MAAM Study: Avastin and Macugen Versus Avastin Versus Macugen

Completed·TThe Ludwig Boltzmann Institute of Retinology and Biomicroscopic Laser Surgery·Phase 2·NCT00531336·60 enrolled

Sources

References

[1]
ClinicalTrials.gov — 13 trial records for Intravitreal injection of Avastin. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — Intravitreal injection of Avastin compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for Intravitreal injection of Avastin. EMBL-EBI & Wellcome Sanger Institute.
[4]
SEC EDGAR — Shahid Beheshti University of Medical Sciences company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[2]
Highest Phase: Phase 1[1]
Company: SShahid Beheshti University of Medical Sciences

Intravitreal injection of Avastin

Status by Indication[3][1]

Competitive Landscape

Trials by Indication[1]

Retinal Vein Occlusion2 trials

Proliferative Diabetic Retinopathy2 trials

Bevacizumab2 trials

Diabetic Macular Edema2 trials

Retinopathy1 trial

Macular Edema1 trial

Choroidal Neovascularization1 trial

Cystoid Macular Edema1 trial

Unspecified1 trial

References

Drug Info

Quick Facts

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