Lactated Ringer

ApprovedSmall molecule

EEnrique de-Madaria

Lactated Ringer is one of 156 small molecule programs targeting Acute Pancreatitis. It is currently in Approved.

Indications

Total Trials

Active Trials

155

Competitors

Pipeline

Status by Indication[3][1]

Indication

Acute PancreatitisActive, not recruiting

Liver TransplantActive, not recruiting

HemorrhageActive, not recruiting

SepsisActive, not recruiting

PancreatitisActive, not recruiting

Acute PancreatitisApproved

Active, not recruiting

Liver TransplantPreclinical

Active, not recruiting

HemorrhageApproved

Active, not recruiting

SepsisPhase 3

Active, not recruiting

PancreatitisPreclinical

Active, not recruiting

Competition

Competitive Landscape

353 competitors in Liver Transplant

#DrugCompanyPhaseTrials

Lactated Ringer

EEnrique de-Madaria

Approved

1 2

Cysteine Hydrochloride

Novartis

Preclinical

3 3

Vemlidy

Gilead

Preclinical

3 4

Lenvima

Eisai

Preclinical

2 5

Octreotide

Johnson & Johnson

Preclinical

2 6

Beyfortus

BeiGene

Preclinical

1 7

Prostigmin

Merck & Co.

Preclinical

1 8

Myfortic

Novartis

Preclinical

1 9

Precedex

MMcNeil Consumer & Specialty Pharmaceuticals, a Division of McNeil-PPC, Inc.

Preclinical

4 10

Myfortic

Novartis

Preclinical

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q3 2026

Phase 1Recruiting

Recovery

NCT07488078

Clinical

Trials by Indication[1]

Sepsis3 trials

Pragmatic Pediatric Trial of Balanced Versus Normal Saline Fluid in Sepsis

Completed·—·Phase 3·NCT04102371·9,041 enrolled

Lactated Ringer Versus Albumin in Early Sepsis Therapy

Completed·UUniversity of Sao Paulo·Phase 3·NCT01337934·360 enrolled

Pragmatic Pediatric Trial of Balanced Versus Normal Saline Fluid in Sepsis: A Pilot Feasibility Study

Completed·—·Phase 1·NCT03340805·50 enrolled

Pancreatitis3 trials

Lactated Ringer's Solution to Prevent Post-ERCP Pancreatitis

Not yet recruiting·UUniversity of South Florida·N/A·NCT03215862·242 enrolled

Trial of Aggressive Hydration Versus Rectal Indomethacin for Prevention of Post-ERCP Pancreatitis

Completed·PPost Graduate Institute of Medical Education and Research, Chandigarh·Phase 2/3·NCT03629600·352 enrolled

Aggressive Hydration With Lactated Ringer's Solution Versus Plasma Solution for the Prevention of Post ERCP Pancreatitis

Completed·DDo Hyun Park·Phase 4·NCT05832047·844 enrolled

Acute Pancreatitis2 trials

Normal Saline Versus Lactated Ringer's Solution for Acute Pancreatitis Resuscitation

Completed·EEnrique de-Madaria·Phase 4·NCT05781243·792 enrolled

Aggressive Versus Non-aggressive Goal-directed Fluid Resuscitation in Acute Pancreatitis

Terminated·EEnrique de-Madaria·Phase 3·NCT04381169·249 enrolled

Postoperative Recovery1 trial

Does Fluid Replacement From Preoperative NPO Status Improve Postoperative Recovery

Completed·WWest Virginia University·N/A·NCT02638623·52 enrolled

Liver Transplant1 trial

Effects of Intraoperative Normal Saline vs Lactated Ringer on Outcomes in Pediatric Liver Transplantation

Unknown status·RRenJi Hospital·N/A·NCT03563378·200 enrolled

11 more indications

Pilot Study1 trial

Enteral Resuscitation Nepal (Pilot Study)

Completed·UUniversity of Washington·Phase 3·NCT04732624·30 enrolled

Urological Surgery1 trial

Effect of Colloid Versus Crystalloid on Coagulation in Elective Urological Surgery

Completed·KK. C. Rasmussen·Phase 4·NCT02009033·40 enrolled

CAR1 trial

Comparison of Lactated Ringer's Solution and PlasmaLyte-A as a Base Solution for Del Nido Cardioplegia

Completed·MMahidol University·N/A·NCT04051580·200 enrolled

Intraoperative1 trial

Impact of Intraoperative Fluid Management on Electrolyte and Acid-base Variables

Completed·NNationwide Children's Hospital·Phase 3·NCT03054922·59 enrolled

Intravenous1 trial

Does Intravenous Lactated Ringer Solution Raise Measured Serum Lactate?

Completed·UUniversity Medical Center of Southern Nevada·Phase 1·NCT02950753·30 enrolled

Recovery1 trial

Effect of Liberal and Restrictive IV Fluids on Recovery After Gallbladder Surgery

Recruiting·KKing Edward Medical University·Phase 1·NCT07488078·380 enrolled

Fluid Resuscitation1 trial

Saline vs. Lactated Ringers for Emergency Department IV Fluid Resuscitation

Completed·NNicholas M Mohr·Phase 4·NCT03133767·157 enrolled

Dexmedetomidine1 trial

Dexmedetomidine Infusion and Surgical Pleth Index In Pediatrics

Completed·FFayoum University Hospital·N/A·NCT05727969·90 enrolled

Hemorrhage1 trial

The Effect of Human Albumin on Coagulation Competence and Hemorrhage

Unknown status·KKirsten Cleemann Rasmussen·Phase 4·NCT02270723·40 enrolled

Spinal Anesthesia1 trial

Comparison of Different Protocols of Fluid Therapy in Severe Preeclamptic Patients Under Spinal Anesthesia

Unknown status·—·Phase 1·NCT03478618·60 enrolled

Unspecified1 trial

Enteral Resuscitation Nepal

Unknown status·NNepal Health Research Council·Phase 3·NCT05559489·240 enrolled

Sources

References

[1]
ClinicalTrials.gov — 21 trial records for Lactated Ringer. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — Lactated Ringer compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for Lactated Ringer. EMBL-EBI & Wellcome Sanger Institute.
[4]
SEC EDGAR — Enrique de-Madaria company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[2]
Highest Phase: Approved[1]
Company: EEnrique de-Madaria

Lactated Ringer

Status by Indication[3][1]

Competitive Landscape

Expected Milestones

Q3 2026

Trials by Indication[1]

Sepsis3 trials

Pancreatitis3 trials

Acute Pancreatitis2 trials

Postoperative Recovery1 trial

Liver Transplant1 trial

Pilot Study1 trial

Urological Surgery1 trial

CAR1 trial

Intraoperative1 trial

Intravenous1 trial

Recovery1 trial

Fluid Resuscitation1 trial

Dexmedetomidine1 trial

Hemorrhage1 trial

Spinal Anesthesia1 trial

Unspecified1 trial

References

Drug Info

Quick Facts

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