Lidocaine and ketamine

Phase 3Small molecule

TThe Cleveland Clinic

Lidocaine and ketamine is one of 4 small molecule programs targeting Abdominal Surgery. It is currently in Phase 3.

Indications

Total Trials

Active Trials

Competitors

Pipeline

Status by Indication[3][1]

Indication

Abdominal SurgeryActive, not recruiting

Abdominal SurgeryPhase 3

Active, not recruiting

Competition

Competitive Landscape

4 competitors in Abdominal Surgery

#DrugCompanyPhaseTrials

Ketalar

AAultman Health Foundation

Phase 3

4 2

Xylocaine

MMEDRx USA, Inc.

Phase 3

3 3

Cyklokapron

JJ Molner

Phase 3

1 4

Lidocaine and ketamine

TThe Cleveland Clinic

Phase 3

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q3 2027

Phase 1Recruiting

Cancer-Related Pain

NCT07408193

Clinical

Trials by Indication[1]

Abdominal Surgery1 trial

Perioperative Lidocaine and Ketamine in Abdominal Surgery

Active, not recruiting·TThe Cleveland Clinic·Phase 3·NCT04084548·420 enrolled

Abdominal Cancer Surgeries1 trial

Effect of Addition of Dexmedetomidine or Ketamine to Intravenous Infusion of Lidocaine on Proinflammatory Cytokines in Pelvi-abdominal Cancer Surgeries.

Completed·—·Phase 1·NCT06631625·45 enrolled

Cancer-related Pain1 trial

The Role of Coadministration of Lidocaine and Ketamine in Opioid-Refractory Chronic Cancer-Related Pain: a Randomized, Double-Blinded, Placebo-Controlled, Cross-Over Trial.

Recruiting·NNational and Kapodistrian University of Athens·Phase 1·NCT07408193·24 enrolled

Sources

References

[1]
ClinicalTrials.gov — 3 trial records for Lidocaine and ketamine. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — Lidocaine and ketamine compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for Lidocaine and ketamine. EMBL-EBI & Wellcome Sanger Institute.
[4]
SEC EDGAR — The Cleveland Clinic company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[2]
Highest Phase: Phase 3[1]
Company: TThe Cleveland Clinic

Lidocaine and ketamine

Status by Indication[3][1]

Competitive Landscape

Expected Milestones

Q3 2027

Trials by Indication[1]

Abdominal Surgery1 trial

Abdominal Cancer Surgeries1 trial

Cancer-related Pain1 trial

References

Drug Info

Quick Facts

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