Menthol

PreclinicalSmall molecule

GSK

Menthol is one of 13 small molecule programs targeting Sleep. It is currently in Preclinical.

Indications

Total Trials

Active Trials

Competitors

Pipeline

Status by Indication[3][1]

Indication

SleepUnknown status

Tobacco UseCompleted

SleepPreclinical

Unknown status

Tobacco UsePreclinical

Completed

Competition

Competitive Landscape

13 competitors in Sleep

#DrugCompanyPhaseTrials

Ambien

PPurdue Pharma LP

Approved

4 2

Precedex

MMcNeil Consumer & Specialty Pharmaceuticals, a Division of McNeil-PPC, Inc.

Approved

3 3

Hetlioz

VVanda Pharmaceuticals

Phase 3

2 4

UBT251

Novo Nordisk

Phase 3

1 5

Belsomra

CCidara Therapeutics Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)

Phase 2

1 6

Bayer Aspirin

Bayer

Phase 1

1 7

Anerem

AAcacia Pharma Ltd

Preclinical

2 8

Ketalar

Boehringer Ingelheim

Preclinical

—9

Capromorelin

UUniversity of Aarhus

Preclinical

1 10

Rhofade

KKenvue Brands

Preclinical

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Clinical

Trials by Indication[1]

Upper Gastrointestinal Endoscopy2 trials

Phase III Open-labeled Study of NPO-11 in Patients Undergoing Therapeutic Upper Gastrointestinal Endoscopy

Completed·NNihon Pharmaceutical Co., Ltd·Phase 3·NCT01411189·33 enrolled

Phase III Study of NPO-11 in Patients Undergoing Therapeutic Upper Gastrointestinal Endoscopy

Completed·NNihon Pharmaceutical Co., Ltd·Phase 3·NCT01411176·85 enrolled

Peripheral Neuropathy2 trials

Topical Menthol for the Treatment of Chemotherapy Induced Peripheral Neuropathy

Terminated·—·Phase 2·NCT01855607·12 enrolled

Topical Menthol +/- Mannitol for Painful Diabetic Peripheral Neuropathy

Completed·UUniversity of British Columbia·Phase 1/2·NCT02728687·72 enrolled

Exercise1 trial

The Influence of Menthol Gel During Exercise With Heat

Completed·UUniversity of Nebraska·Phase 4·NCT05302804·12 enrolled

Blood Pressure1 trial

Effects and Safety of Menthol on Blood Pressure and Metabolic Parameters in Prehypertensive and Mild Hypertensive Patients

Completed·ZZhiming Zhu·Phase 2/3·NCT01408446·36 enrolled

Sleep1 trial

The Effects of Nasal Airflow on Upper Airway Dilator Muscles During Sleep

Unknown status·—·N/A·NCT03506178·30 enrolled

7 more indications

Diclofenac1 trial

Pharmacokinetics Study Comparing Topical Diclofenac/Menthol Gels With Voltaren Gel and Oral Diclofenac Sodium

Completed· GSK logo

GSK·Phase 1·NCT02201238·18 enrolled

Pain1 trial

Menthol for PDT Pain Relief

Completed·UUniversity of Dundee·Phase 4·NCT02984072·10 enrolled

Tobacco Use1 trial

The Effects of Menthol as Delivered by an Electronic Cigarette on the Desirability of Nicotine in Tobacco Users

Completed·YYale University·N/A·NCT02102100·57 enrolled

Delayed Onset Muscle Soreness1 trial

A Study to Evaluate the Efficacy and Safety of K-285 Compared With Menthol Gel for the Treatment of Delayed Onset Muscle Soreness (DOMS) in the Lower Extremity

Terminated·KKowa Research Institute, Inc.·Phase 2·NCT04484428·126 enrolled

Ischemic stroke1 trial

TRPM8 in Acute Ischemic Stroke by Topical Menthol

Completed·TTaipei Medical University Hospital·Phase 2·NCT05877079·60 enrolled

Skin1 trial

A Safety Study to Investigate the Skin Sensitization Potential of MFC51123

Completed· GSK logo

GSK·Phase 1·NCT02192203·227 enrolled

Regulation of Energy Expenditure1 trial

Targeted TRPM8 Stimulation and Brown Adipose Tissue Activation in Humans

Completed·IIndiana University·Phase 1·NCT07030725·12 enrolled

Sources

References

[1]
ClinicalTrials.gov — 14 trial records for Menthol. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — Menthol compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for Menthol. EMBL-EBI & Wellcome Sanger Institute.
[4]
SEC EDGAR — GSK company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[2]
Highest Phase: Preclinical[1]
Company: GSK

Menthol

Status by Indication[3][1]

Competitive Landscape

Trials by Indication[1]

Upper Gastrointestinal Endoscopy2 trials

Peripheral Neuropathy2 trials

Exercise1 trial

Blood Pressure1 trial

Sleep1 trial

Diclofenac1 trial

Pain1 trial

Tobacco Use1 trial

Delayed Onset Muscle Soreness1 trial

Ischemic stroke1 trial

Skin1 trial

Regulation of Energy Expenditure1 trial

References

Drug Info

Quick Facts

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