Metformin HCl

Pipeline

Status by Indication[3][1]

Competition

Competitive Landscape

Type 2 DiabetesCirrhosisPolycystic Ovary SyndromeInsulin ResistanceFanconi Anemia

885 competitors in Type 2 Diabetes

#DrugCompanyPhaseTrials

1

Metformin HCl

Boehringer Ingelheim

Phase 3

32

Jardiance

Boehringer Ingelheim

Preclinical

313

NOVOLIN R

Novo Nordisk

Preclinical

54

Pravachol

KKaruna Therapeutics, Inc., a Bristol Myers Squibb company

Preclinical

15

Cecon

MMcGuff Pharmaceuticals, Inc.

Preclinical

16

Forxiga

AstraZeneca

Preclinical

37

Lovaza

AstraZeneca

Preclinical

18

Sulfonylureas

Eli Lilly

Preclinical

19

Acipimox

Boehringer Ingelheim

Preclinical

210

GLP-1

RRigshospitalet, Denmark

Preclinical

1Show 15 more competitors

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Clinical

Trials by Indication[1]

Type 2 Diabetes3 trials

Safety and Efficacy Study of Empagliflozin and Metformin for 24 Weeks in Treatment Naive Patients With Type 2 Diabetes

Completed·Boehringer Ingelheim·Phase 3·NCT01719003·1,413 enrolled

A Research Study to Determine the Safety and Efficacy of Glucovance Compared to Metformin and Glyburide in Children and Adolescents With Type 2 Diabetes.

Completed·Bristol-Myers Squibb·Phase 3·NCT00035542

Efficacy and Safety of Alogliptin and Metformin Fixed-Dose Combination in Participants With Type 2 Diabetes

Completed·Takeda·Phase 3·NCT01890122·647 enrolled

Metformin3 trials

Comparison of the Bioavailability of Metformin Between Medium Dose Linagliptin/Metformin Tablets and Medium Dose Glucophage Tablet Given With Linagliptin Tablet

Completed·Boehringer Ingelheim·Phase 1·NCT01383356·58 enrolled

DDI (Effect of Metformin and Furosemide on Rosuvastatin PK)

Completed·Boehringer Ingelheim·Phase 1·NCT02574845·18 enrolled

Impact of Genetics on Metformin Pharmacokinetics

Completed·UUniversity of California, San Francisco·N/A·NCT00187798·24 enrolled

Insulin resistance2 trials

Fiber and Metformin Combination Therapy in Adolescents With Severe Obesity and Insulin Resistance

Recruiting·UUniversity of Alberta·Phase 3·NCT04578652·90 enrolled

Metformin to Treat Obesity in Children With Insulin Resistance

Completed·—·Phase 2·NCT00005669·100 enrolled

Adult Subject2 trials

Study to Evaluate the Bioequivalence of a Test Tablet Formulation of Metformin HCl (1000 mg), Compared to an Equivalent Dose of a Commercially Available Reference Drug Product (Glucophage®, Bristol-Myers Squibb Company) in Fed, Healthy, Adult Subjects

Completed·TTorrent Pharmaceuticals Limited·Phase 1·NCT00944346

Study to Evaluate the Bioequivalence of a Test Tablet Formulation of Metformin HCl (1000 mg), Compared to an Equivalent Dose of a Commercially Available Reference Drug Product (Glucophage®, Bristol-Myers Squibb Company) in Fasted, Healthy, Adult Subjects

Completed·TTorrent Pharmaceuticals Limited·Phase 1·NCT00944177

Empagliflozin2 trials

This Study in Healthy People Tests Whether Taking a Low Strength of Empagliflozin, Linagliptin, and Metformin Together in 1 Pill is the Same as Taking Them in Separate Pills

Completed·Boehringer Ingelheim·Phase 1·NCT03629054·30 enrolled

This Study Tests Whether Taking the Medicines Empagliflozin, Linagliptin, and Metformin Together in 1 Pill is the Same as Taking Them in Separate Pills. The Study is Done in Healthy Men and Women and Measures the Amount of Each Medicine in the Blood

Completed·Boehringer Ingelheim·Phase 1·NCT03259490·30 enrolled

5 more indications

Adult2 trials

A Study to Evaluate the Pharmacokinetics and Safety Between "BR3006" and Co-administration of "BR3006A", "BR3006B", and "BR3006C" in Healthy Adult Volunteers (Fed)

Recruiting·Boryung Pharmaceutical Co., Ltd·Phase 1·NCT07083401·40 enrolled

A Study to Evaluate the Pharmacokinetics and Safety Between "BR3006" and Co-administration of "BR3006A", "BR3006B", and "BR3006C" in Healthy Adult Volunteers (Fasting)

Recruiting·Boryung Pharmaceutical Co., Ltd·Phase 1·NCT07083388·52 enrolled

Cirrhosis1 trial

A Study to Compare How Different Medicines (Rosuvastatin, Digoxin, Metformin, and Furosemide) Are Handled by the Body of Healthy People and People With Liver Cirrhosis

Completed·Boehringer Ingelheim·N/A·NCT05741372·28 enrolled

Efficacy and Safety1 trial

Study Comparing Efficacy and Safety of Amaryl M and Metformin Uptitraion to Type 2 DM

Completed·HHandok Inc.·Phase 4·NCT00612144·192 enrolled

Fanconi Anemia1 trial

Pilot Study of Metformin for Patients With Fanconi Anemia

Completed·—·Phase 2·NCT03398824·15 enrolled

Polycystic Ovary Syndrome1 trial

Letrozole or Combined Metformin Clomiphene Citrate (CC) for Women With CC Resistant Polycystic Ovary Syndrome

Completed·MMansoura University·N/A·NCT00911313·250 enrolled

Details

Drug Info

Related News