Rifampicin

Phase 3Small molecule

Boehringer Ingelheim

Rifampicin is one of 200 small molecule programs targeting Tics. It is currently in Phase 3.

Indications

144

Total Trials

Active Trials

199

Competitors

Pipeline

Status by Indication[3][1]

Indication

TicsCompleted

Colorectal CancerActive, not recruiting

InteractionNot yet recruiting

Pediatric HIV InfectionRecruiting

MethotrexateUnknown status

Mycobacterium Avium Complex Pulmonary DiseaseRecruiting

AdultNot yet recruiting

AbsorptionCompleted

Mycobacterium Avium ComplexRecruiting

NACRecruiting

TicsPhase 1

Completed

Colorectal CancerPreclinical

Active, not recruiting

InteractionPhase 3

Not yet recruiting

Pediatric HIV InfectionPhase 1

Recruiting

MethotrexatePhase 1

Unknown status

Mycobacterium Avium Complex Pulmonary DiseasePhase 3

Recruiting

AdultPhase 3

Not yet recruiting

AbsorptionPreclinical

Completed

Mycobacterium Avium ComplexPhase 3

Recruiting

NACPhase 2

Recruiting

Showing 10 of 11 indications

Competition

Competitive Landscape

254 competitors in Colorectal Cancer

#DrugCompanyPhaseTrials

Stivarga

Bayer

Phase 3

39 2

Camptosar

Pfizer

Phase 3

34 3

Keytruda

Merck & Co.

Phase 3

25 4

Fudr

Pfizer

Phase 3

17 5

Adrucil

EElorac, Inc.

Phase 3

86 6

Wellcovorin

EEastern Cooperative Oncology Group

Phase 3

58 7

Tyvyt

Innovent Biologics (Suzhou) Co. Ltd.

Phase 3

8 8

Platinol

MMcNeil Consumer & Specialty Pharmaceuticals, a Division of McNeil-PPC, Inc.

Phase 3

4 9

Botensilimab

AAgenus Inc.

Phase 3

9 10

Cadonilimab

SShanghai Pharmaceuticals Holding Co., Ltd

Phase 3

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q4 2026

Phase 3Not yet recruiting

Pulmonary Tuberculosis

NCT04485156

Phase 1Not yet recruiting

Study completion

NCT07875842

Phase 1Recruiting

Pediatric HIV Infection

NCT05069688

Q1 2027

Phase 2Active, not recruiting

Tuberculosis, Pulmonary

NCT05556746

Phase 1Not yet recruiting

Interaction

NCT07429331

Phase 1Not yet recruiting

Breast Cancer

NCT07876596

Clinical

Trials by Indication[1]

Interaction22 trials

Pharmacokinetic Drug Interaction Study in Healthy Male Subjects

Completed·LLG Life Sciences·Phase 1·NCT01426906·24 enrolled

Drug-Drug Interaction (DDI) Study for TPN171H

Completed·VVigonvita Life Sciences·Phase 1·NCT06090123·24 enrolled

A Drug Interaction Study of KW-6356 and Clarithromycin or Rifampicin

Completed· Kyowa Kirin Co., Ltd. logo

Kyowa Kirin Co., Ltd.·Phase 1·NCT04070495·20 enrolled

Show 19 more trials

Drug-drug Interaction Trial Between Rifampicin and BI 409306 in Healthy Volunteers

Completed· Boehringer Ingelheim logo

Boehringer Ingelheim·Phase 1·NCT03151499·15 enrolled

A Drug-Drug Interaction Study of Ketoconazole, Rifampicin and Ritonavir-Boosted Atazanavir With Single-Dose RO5093151 in Healthy Volunteers

Completed· Roche logo

Roche·Phase 1·NCT01591850·51 enrolled

PK Interaction Between Rifapentine or Rifampicin and a Single Dose of TMC207 in Healthy Subjects (TMC207-CL002)

Completed·GGlobal Alliance for TB Drug Development·Phase 1·NCT02216331·32 enrolled

Drug-drug Interaction Study Between Orally Administered Rifampicin and Vilaprisan

Completed· Bayer logo

Bayer·Phase 1·NCT02975440·12 enrolled

Drug-drug Interaction Between Rifampicin and Progestins/Ethinylestradiol and Midazolam

Completed· Bayer logo

Bayer·Phase 1·NCT03353857·68 enrolled

Drug Interaction Study

Completed·EEmalex Biosciences Inc.·Phase 1·NCT06194864·45 enrolled

Drug Interaction Study With Rifampicin and Afatinib

Completed· Boehringer Ingelheim logo

Boehringer Ingelheim·Phase 1·NCT01396265·22 enrolled

Drug-drug Interaction Study of Gepotidacin

Completed· GSK logo

GSK·Phase 1·NCT04493931·64 enrolled

Drug-drug Interaction (DDI) Study to Assess ODM-201 as a Victim of CYP3A4 Inhibition or Induction

Completed· Bayer logo

Bayer·Phase 1·NCT03048110·15 enrolled

A Drug-drug Interaction Trial to Evaluate the Pharmacokinetics Effect of Rifampicin on Famitinib

Completed·JJiangsu HengRui Medicine Co., Ltd.·Phase 1·NCT04494659·21 enrolled

Study on Food Influence and Drug-drug Interaction of HLX208 Tablets in Chinese Healthy Subjects

Completed· Shanghai Henlius Biotech logo

Shanghai Henlius Biotech·Phase 1·NCT05902728·20 enrolled

A Study in Healthy Volunteers to Evaluate the Drug-Drug Interaction Potential of CCX168 With Concomitant Medications

Completed· Amgen logo

Amgen·Phase 1·NCT06004947·32 enrolled

Drug-drug Interaction Between Belumosudil, Itraconazole, Rifampicin, Rabeprazole, and Omeprazole in Healthy Volunteers

Completed·KKadmon Corporation, LLC·Phase 1·NCT03530995·73 enrolled

Drug-drug Interaction Study of Rifampin and Anaprazole Sodium

Not yet recruiting·XXuanzhu Biopharmaceutical Co., Ltd.·Phase 4·NCT07330531·24 enrolled

A Study to Evaluate Drug-Drug Interaction of TQB3909 Tablets

Unknown status· Chia Tai Tianqing Pharmaceutical Group Co., Ltd. logo

Chia Tai Tianqing Pharmaceutical Group Co., Ltd.·Phase 1·NCT06165822·40 enrolled

A Study to Evaluate Drug-Drug Interaction of TQ05105 Tablets

Completed· Chia Tai Tianqing Pharmaceutical Group Co., Ltd. logo

Chia Tai Tianqing Pharmaceutical Group Co., Ltd.·Phase 1·NCT06024915·40 enrolled

Drug Interaction and Food Effect Study of CS0159

Not yet recruiting·CCascade Pharmaceuticals, Inc·Phase 1·NCT07429331·32 enrolled

Drug-drug Interaction (DDI) Study to Assess Effect of Itraconazole and Rifampicin Upon Olorofim

Completed·FF2G Biotech GmbH·Phase 1·NCT04171739·24 enrolled

A Drug-drug Interaction Trial of Rifampicin Pharmacokinetics Effect on Fluzoparib

Completed·JJiangsu HengRui Medicine Co., Ltd.·Phase 1·NCT04011124·16 enrolled

Tics16 trials

A Study To Evaluate The Effect Of Rifampicin Or Ltraconazole On Pharmacokinetics Of Ensartinib In Healthy Volunteers

Not yet recruiting·BBetta Pharmaceuticals Co., Ltd.·Phase 1·NCT06492525·36 enrolled

A Phase I Study to Assess the Effect of Itraconazole and Rifampicin on Pharmacokinetics Profile of BPI-7711

Completed·BBeta Pharma, Inc.·Phase 1·NCT04135833·31 enrolled

Effect of Rifampicin on the Pharmacokinetics and Pharmacodynamics of Sotagliflozin

Completed· Sanofi logo

Sanofi·Phase 1·NCT03063580·16 enrolled

Show 13 more trials

A Study to Assess the Effects of Itraconazole, Rifampicin, and Omeprazole on Pharmacokinetics of Adavosertib

Terminated· AstraZeneca logo

AstraZeneca·Phase 1·NCT04959266·5 enrolled

To Assess the Effect of Rifampicin on the Pharmacokinetics of Selumetinib in Healthy Male Volunteers

Completed· AstraZeneca logo

AstraZeneca·Phase 1·NCT02046850·24 enrolled

Study to Evaluate the Effects of Itraconazole and Rifampin on the Pharmacokinetics of ASC40 in Healthy Subjects

Completed·AAscletis Pharmaceuticals Co., Ltd.·Phase 1·NCT04843449·24 enrolled

Study to Evaluate the Effect of Multiple Doses of Rifampicin on the Multiple-dose Pharmacokinetics of Linagliptin in Healthy Volunteers

Completed· Boehringer Ingelheim logo

Boehringer Ingelheim·Phase 1·NCT02183584·16 enrolled

Effect of a Potent Inducer Rifampicin on the Pharmacokinetics of Deferasirox in Healthy Volunteers

Completed· Novartis logo

Novartis·Phase 1·NCT00419172·22 enrolled

A Study to Investigate the Effects of Rifampicin on the Pharmacokinetics of Aleglitazar in Healthy Volunteers

Completed· Roche logo

Roche·Phase 1·NCT01679639·24 enrolled

The Effect of Itraconazole and Rifampicin on the Pharmacokinetics of SH-1028

Unknown status·NNanjing Sanhome Pharmaceutical, Co., Ltd.·Phase 1·NCT04808648·40 enrolled

A Study to Evaluate the Effect of Itraconazole and Rifampicin on the Pharmacokinetics of Jaktinib in Healthy Volunteers

Completed·SSuzhou Zelgen Biopharmaceuticals Co.,Ltd·Phase 1·NCT06246695·40 enrolled

A Study Evaluating the Effects of Itraconazole or Rifampin on the Pharmacokinetic Characteristics of Rocbrutinib Tablet

Recruiting·GGuangzhou Lupeng Pharmaceutical Company LTD.·Phase 1·NCT07374224·28 enrolled

Pharmacokinetics of Verinurad and Allopurinol in Combination With Cyclosporine and Rifampicin in Healthy Volunteers

Completed· AstraZeneca logo

AstraZeneca·Phase 1·NCT04532918·14 enrolled

A Study in Healthy Subjects to Assess the Pharmacokinetics of Savolitinib When Administered Alone and in Combination With Rifampicin

Completed· AstraZeneca logo

AstraZeneca·Phase 1·NCT04118842·40 enrolled

A Study to Evaluate the Effect of Rifampicin on the Pharmacokinetics of Abiraterone in Healthy Male Participants

Completed· Johnson & Johnson logo

Johnson & Johnson·Phase 1·NCT01655147·19 enrolled

Studies Evaluating the Effects of Itraconazole or Rifampicin on the Pharmacokinetics of TY-9591 Tablets in Healthy Subjects

Completed·TTYK Medicines, Inc·Phase 1·NCT06255951·48 enrolled

Tuberculosis12 trials

Rifampicin vs Rifabutin in HIV/AIDS Patients Combined With Tuberculosis

Unknown status·SShanghai Public Health Clinical Center·N/A·NCT03478033·230 enrolled

Evaluating Celecoxib Activity in Mycobacterium Tuberculosis: A Whole Blood Bactericidal Activity Study in Healthy Volunteers

Completed·NNational University Hospital, Singapore·Phase 1·NCT02602509·18 enrolled

Measurement of Anti-TB Drugs in Lung Tissue From Patients Having Surgery to Treat Tuberculosis

Completed·NNational Institute of Allergy and Infectious Diseases (NIAID)·Phase 1·NCT00816426·19 enrolled

Show 9 more trials

Efficacy and Safety of Intravenous Treatment of Tuberculosis

Terminated·YYuria-Pharm··NCT04150367·166 enrolled

Short-Course Regimen With Bedaquiline, Moxifloxacin and Pyrazinamide for Early Bactericidal Activity in Drug-Susceptible Tuberculosis

Not yet recruiting·SShanghai Pulmonary Hospital, Shanghai, China·Phase 2·NCT07129629·45 enrolled

Rosuvastatin Evaluation as a Tuberculosis Treatment Adjunct

Unknown status·NNational University Hospital, Singapore·Phase 2·NCT04504851·154 enrolled

Whole Blood Bactericidal Activity (WBA) Against Mycobacterium Tuberculosis of Faropenem Plus Amoxicillin/Clavulanic Acid in Healthy Volunteers

Completed·NNational University Hospital, Singapore·Phase 1·NCT02393586·43 enrolled

The Optimal Duration of Preoperative Anti-tuberculosis Treatment of Spinal Tuberculosis

Unknown status·—·Phase 4·NCT02477852·400 enrolled

Two-month Regimens Using Novel Combinations to Augment Treatment Effectiveness for Drug-sensitive Tuberculosis

Completed·UUniversity College, London·Phase 2/3·NCT03474198·675 enrolled

Whole Blood Bactericidal Activity (WBA) Against Mycobacterium Tuberculosis of Rifampicin in Healthy Volunteers

Suspended·NNational University Hospital, Singapore·Phase 1·NCT02387242·18 enrolled

Multi-arm, Open-label, Duration-randomized, Phase IIc Study of the Efficacy, Safety, Tolerability, and Pharmacokinetics of Optimized Rifampicin in Combination With Isoniazid, Pyrazinamide, and Ethambutol for the Treatment of Children With Drug-susceptible Tuberculosis

Not yet recruiting·UUniversity of Wisconsin, Madison·Phase 2·NCT07656012·230 enrolled

A Prospective, Randomized Open-Label Phase II Study of the Safety and Tolerability of Metformin in Combination With Standard Antimicrobial Treatment of Pulmonary Tuberculosis in People Co-infected With HIV

Completed·UUniversity of Massachusetts, Worcester·Phase 2·NCT04930744·112 enrolled

Pulmonary Tuberculosis7 trials

Trial of Faropenem and Cefadroxil (in Combination With Amoxicillin/Clavulanic Acid and Standard TB Drugs) in Patients With Pulmonary Tuberculosis: Measurement of Early Bactericidal Activity and Effects on Novel Biomarkers

Completed·NNational University Hospital, Singapore·Phase 2·NCT02381470·58 enrolled

Treatment Shortening of Drug-Sensitive Pulmonary Tuberculosis Using High Dose Rifampicin (Hi-DoRi-3)

Not yet recruiting·SSeoul National University Hospital·Phase 3·NCT04485156·926 enrolled

Fermented Soybean Supplementation Among Active Pulmonary Tuberculosis Patients With Standard Therapy in Indonesia

Completed·UUniversity of Giessen·N/A·NCT02554318·147 enrolled

Show 4 more trials

Shortened Regimens for Drug-susceptible Pulmonary Tuberculosis

Unknown status·—·Phase 4·NCT02901288·3,900 enrolled

A Randomised Trial to Evaluate Toxicity and Efficacy of 1200mg and 1800mg Rifampicin for Pulmonary Tuberculosis

Completed·SSt George's, University of London·Phase 3·NCT02581527·672 enrolled

A Phase 2 Randomized, Adaptive, Dose-Ranging, Open-Label Trial of Novel Regimens for the Treatment of Pulmonary Tuberculosis

Suspended·NNational Institute of Allergy and Infectious Diseases (NIAID)·Phase 2·NCT06192160·341 enrolled

A Seamless Phase 2B/C Platform Trial to Evaluate Multiple Regimens and Durations of Treatment in Pulmonary Tuberculosis

Recruiting·UUniversity College, London·Phase 2·NCT06114628·2,500 enrolled

Drug Interactions6 trials

Prediction of Drug Interactions With CYP2C9 Substrates

Completed·HHadassah Medical Organization·N/A·NCT00226538·16 enrolled

Sulforaphane as an Antagonist to Human PXR-mediated Drug-drug Interactions

Completed·UUniversity of Washington·Phase 1·NCT00621309·29 enrolled

A Study to Learn About the Drug-drug Interactions of Sisunatovir in Healthy Adult Participants

Completed· Pfizer logo

Pfizer·Phase 1·NCT03782662·82 enrolled

Show 3 more trials

A Clinical Trial to Evaluate JAB-21822 Drug-drug Interactions in Healthy Subjects

Completed·AAllist Pharmaceuticals, Inc.·Phase 1·NCT06162169·66 enrolled

Drug Interactions Trial of Methoxyethyl Etomidate Hydrochloride

Completed·AAhon Pharmaceutical Co., Ltd.·Phase 1·NCT06822166·68 enrolled

A Study to Investigate the Drug-drug Interactions (DDIs) of SKLB1028 With Itraconazole, Gemfibrozil or Rifampicin in Healthy Subjects

Unknown status· CSPC ZhongQi Pharmaceutical Technology Co., Ltd. logo

CSPC ZhongQi Pharmaceutical Technology Co., Ltd.·Phase 1·NCT05069870·42 enrolled

53 more indications

Meningitis3 trials

Trial of a Six-Month Regimen of High-Dose Rifampicin, High-Dose Isoniazid, Linezolid, and Pyrazinamide Versus a Standard Nine-Month Regimen for the Treatment of Adults and Adolescents With Tuberculous Meningitis

Recruiting·NNational Institute of Allergy and Infectious Diseases (NIAID)·Phase 2·NCT05383742·330 enrolled

High-dose Rifampicin for the Treatment of Tuberculous Meningitis: a Dose-finding Study

Completed·UUniversitas Padjadjaran·Phase 2/3·NCT02169882·60 enrolled

Rifampicin Explorative PK Study for Tuberculous Meningitis Comparing Oral and Intravenous Preparation

Completed·UUniversitas Padjadjaran·Phase 2·NCT01802502·30 enrolled

Concentration3 trials

To Evaluate if Multiple Doses of Rifampicin Change the Blood Concentration of YM150 (Darexaban)

Completed· Astellas logo

Astellas·Phase 1·NCT01406002·26 enrolled

A Clinical Study to Investigate the Effect of Gemfibrozil or Rifampicin on Blood Concentrations of Selexipag in Healthy Subjects

Completed· Johnson & Johnson logo

Johnson & Johnson·Phase 1·NCT02770222·40 enrolled

Effects of Administration of Fostamatinib on Blood Concentrations of Rifampicin in Healthy Subjects.

Completed· AstraZeneca logo

AstraZeneca·Phase 1·NCT01336218·15 enrolled

Adult3 trials

Evaluate the Effect of Clarithromycin/Rifampicin on the Pharmacokinetics of DA-8010 in Healthy Adults

Completed·DDong-A ST Co., Ltd.·Phase 1·NCT05991401·18 enrolled

Intensified Short Course Regimen for TBM in Adults

Not yet recruiting·IIndian Council of Medical Research·Phase 3·NCT05917340·372 enrolled

A Study to Assess the Effects of Itraconazole and Rifampicin on the Single-Dose Pharmacokinetics of JNJ-53718678 in Healthy Adults

Completed· Johnson & Johnson logo

Johnson & Johnson·Phase 1·NCT02729467·33 enrolled

Tuberculosis, Pulmonary3 trials

Multi-centric Prospective Cohort Study of TB Recurrence Free Cure Among Microbiologically Confirmed New Pulmonary Tuberculosis Patients Treated Under NTEP With the 4-month Moxifloxacin Containing Daily Regimen

Completed·TTuberculosis Research Centre, India··NCT05047055·550 enrolled

A Prospective Multicenter Phase II-study: Pharmacokinetics and Safety of High-Dose Rifampicin and Pyrazinamide in a Shorter Tuberculosis Treatment Compared With Standardized Treatment in Patients With Mild to Moderate Pulmonary TB

Suspended·UUniversity Hospital, Linkoeping·Phase 2·NCT04694586·40 enrolled

A Phase IIc, Open-Label, Randomized Controlled Trial of Ultra-Short Course Bedaquiline, Clofazimine, Pyrazinamide and Delamanid Versus Standard Therapy for Drug-Susceptible Tuberculosis (PRESCIENT)

Active, not recruiting·BBrigham and Women's Hospital·Phase 2·NCT05556746·94 enrolled

ESS2 trials

Evaluation and Validation of Metabolic Markers for the Assessment of CYP3A Activity and Prediction of DDI

Completed·SSeoul National University Hospital·Phase 1·NCT02328443·24 enrolled

Identification and Evaluation of Endogenous Markers for the Assessment of CYP3A Activity

Completed·SSeoul National University Hospital·Phase 1·NCT01760642·16 enrolled

Single Dose2 trials

Relative Bioavailability of a Single Dose of Nintedanib Given Alone and in Combination With Multiple Doses of Rifampicin

Completed· Boehringer Ingelheim logo

Boehringer Ingelheim·Phase 1·NCT01770392·26 enrolled

Relative Bioavailability of Single Doses of Dabigatran Etexilate in Healthy Volunteers

Completed· Boehringer Ingelheim logo

Boehringer Ingelheim·Phase 1·NCT02173717·24 enrolled

Homeostasis2 trials

Pregnane X Receptor (PXR) Agonist Rifampicin Effects on Glucose, Lipid and Hormone Homeostasis

Completed·UUniversity of Oulu·Phase 4·NCT00985270·12 enrolled

Effects of Pregnane X Receptor (PXR) Activation on Human Glucose, Lipid and Hormone Homeostasis

Completed·UUniversity of Oulu·Phase 4·NCT01293422·12 enrolled

Adult Subject2 trials

Study of Drug-drug Interaction of the Effects of Gemfibrozil and Rifampicin on SAR442168 in Healthy Adult Subjects

Completed· Sanofi logo

Sanofi·Phase 1·NCT06064539·30 enrolled

Early Bactericidal Activity (EBA) of SQ109 in Adult Subjects With Pulmonary TB

Completed·MMichael Hoelscher·Phase 2·NCT01218217·90 enrolled

Methotrexate2 trials

A Drug-drug Interaction Study to Evaluate the Effect of Rifampicin on the Pharmacokinetics of Methotrexate in Elderly Subjects

Unknown status·SSeoul National University Bundang Hospital·Phase 1·NCT06108453·10 enrolled

Drug-Drug Interaction of Rifampicin and Cyclosporine on Methotrexate Pharmacokinetics in Healthy Subjects

Active, not recruiting·SSeoul National University Bundang Hospital·Phase 1·NCT07196449·12 enrolled

Pulmonary TB2 trials

Evaluation of SQ109, High-dose Rifampicin, and Moxifloxacin in Adults With Smear-positive Pulmonary TB in a MAMS Design

Completed·MMichael Hoelscher·Phase 2·NCT01785186·365 enrolled

Safety, Tolerability, Extended Early Bactericidal Activity and PK of Higher Doses Rifampicin in Adults With Pulmonary TB

Completed·RRadboud University Medical Center·Phase 2·NCT01392911·128 enrolled

Fed1 trial

Study in Healthy Male Subjects to Evaluate the Effect of Itraconazole and Rifampicin on the PK of Fedovapagon

Completed·VVantia Ltd·Phase 1·NCT02440841·29 enrolled

Mycobacterium Avium Complex1 trial

CLArithromycin Versus AZIthromycin in the Treatment of Mycobacterium Avium Complex (MAC) Lung Infections

Recruiting·—·Phase 3·NCT03236987·424 enrolled

Advanced Cancer1 trial

A Study in People With Advanced Cancer to Test Whether the Amount of BI 907828 in the Blood is Influenced by Taking an OATP Inhibitor or a CYP3 Inhibitor

Completed· Boehringer Ingelheim logo

Boehringer Ingelheim·Phase 1·NCT05372367·33 enrolled

MPA1 trial

EVRIOS : Comparative Evaluation of Low Versus High Doses of Rifampicin

Completed·RRennes University Hospital·Phase 4·NCT02599493·544 enrolled

Lung Disease1 trial

A Study of Bedaquiline Administered as Part of a Treatment Regimen With Clarithromycin and Ethambutol in Adult Patients With Treatment-refractory Mycobacterium Avium Complex-lung Disease (MAC-LD)

Completed· Johnson & Johnson logo

Johnson & Johnson·Phase 2/3·NCT04630145·129 enrolled

Leprosy1 trial

Post ExpOsure Prophylaxis for LEprosy in the Comoros and Madagascar

Completed·IInstitute of Tropical Medicine, Belgium·Phase 3·NCT03662022·144,000 enrolled

Treatment1 trial

Rifabutin Versus Rifampicin for Treatment of Staphylococcal PJI Treated With DAIR

Recruiting·TTourcoing Hospital·Phase 3·NCT04672525·436 enrolled

Multiple System Atrophy1 trial

Study of Rifampicin in Multiple System Atrophy

Terminated·PPhillip Low·Phase 3·NCT01287221·100 enrolled

Lymphoma1 trial

A Safety and Efficacy Study of CC-90011 in Participants With Relapsed and/or Refractory Solid Tumors and Non-Hodgkin's Lymphomas

Terminated· Bristol-Myers Squibb logo

Bristol-Myers Squibb·Phase 1·NCT02875223·75 enrolled

Advanced Solid Tumors1 trial

To Assess the Effect of Rifampicin on the Pharmacokinetics of Eribulin Mesylate in Participants With Advanced Solid Tumors

Completed· Eisai logo

Eisai·Phase 1·NCT03002493·14 enrolled

Blood Pressure1 trial

The Effect of PXR Activation on Blood Pressure Regulation

Completed·UUniversity of Oulu·Phase 4·NCT01690104·22 enrolled

Endocarditis1 trial

Oral Switch During Treatment of Left-sided Endocarditis Due to Multi-susceptible Staphylococcus

Completed·UUniversity Hospital, Tours·Phase 3·NCT02701608·162 enrolled

Pregnancy1 trial

Pharmacokinetic Study of Antiretroviral Drugs and Related Drugs During and After Pregnancy

Completed·NNational Institute of Allergy and Infectious Diseases (NIAID)··NCT00042289·1,578 enrolled

NAC1 trial

PanACEA - STEP2C -01

Recruiting·MMichael Hoelscher·Phase 2·NCT05807399·390 enrolled

Pilot Study1 trial

A Pilot Study for Pharmacokinetic Parameter of Colchicine in Patient Taking Rifampin

Completed·SSeoul National University Hospital·Phase 2·NCT01932268·2 enrolled

Buprenorphine1 trial

Effects of Rifampicin on the Pharmacokinetics and Pharmacodynamics of Sublingual and Intravenous Buprenorphine

Completed·TTurku University Hospital·Phase 4·NCT01854489·12 enrolled

Methicillin-resistant Staphylococcus Aureus1 trial

Randomized Clinical Trial to Compare a Regimen of Trimethoprim-sulfamethoxazole Plus Rifampicin With a Regimen of Linezolid in the Treatment of Methicillin-Resistant Staphylococcus Aureus (MRSA) Infection

Completed·UUniversity Hospital, Geneva·Phase 4·NCT00711854·150 enrolled

TIA1 trial

Essentiality of INH in TB Therapy

Completed·AAdvancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections·Phase 2·NCT01589497·69 enrolled

Rhinoscleroma1 trial

Comparison Between Rifampicin and Gemifloxacin and Ciprofloxacin in Treatment of Rhinoscleroma

Unknown status·—·Phase 1·NCT03326050·60 enrolled

Mycobacterium Avium Complex Pulmonary Disease1 trial

Short-term Antibiotic Therapy in Mycobacterium Avium Complex Pulmonary Disease

Recruiting·BBin Cao·Phase 4·NCT07213765·188 enrolled

Elderly1 trial

Ultra-Short Regimen for Elderly DS-TB

Not yet recruiting·SShenzhen Third People's Hospital·Phase 3·NCT07076225·300 enrolled

Trial1 trial

A PAN-USR TB Multi-Center Trial

Recruiting·SShenzhen Third People's Hospital·Phase 3·NCT06905522·610 enrolled

Female1 trial

A Cross-over Study to Evaluate the Effect of Itraconazole and Rifampicin on the Pharmacokinetics (PK) of GSK525762 in Healthy Female Subjects of Non Child Bearing Potential

Completed· GSK logo

GSK·Phase 1·NCT02706535·29 enrolled

Apatinib1 trial

Effect of Rifampicin on the Pharmacokinetics of Apatinib

Completed·JJiangsu HengRui Medicine Co., Ltd.·Phase 1·NCT02836821·20 enrolled

Colorectal Cancer1 trial

Mechanical Bowel Preparation With or Without Oral Antibiotics in Left Sided Colorectal Cancer Surgery

Enrolling by invitation·SShaukat Khanum Memorial Cancer Hospital & Research Centre·N/A·NCT07429760·60 enrolled

Oral1 trial

A Study to Evaluate the Effect of Rifampicin on the Pharmacokinetics of Oral HRS-5041 in Healthy Subjects

Completed·JJiangsu HengRui Medicine Co., Ltd.·Phase 1·NCT07014488·16 enrolled

Antibiotic Therapy1 trial

Rifampin-combined Antibiotic Therapy for Staphylococcal PJI

Recruiting·FFirst Affiliated Hospital of Fujian Medical University·N/A·NCT07313215·428 enrolled

Drug1 trial

PK Study of Anti-TB Drugs

Completed·UUniversity of Oxford·Phase 1·NCT02457208·61 enrolled

Absorption1 trial

Immune Activation and Drug Absorption in HIV-Infected Patients

Completed·—·N/A·NCT01845298·7 enrolled

Chronic Inflammation1 trial

Impact of LTBI Treatment on Glucose Tolerance and Chronic Inflammation

Completed·HHerlev and Gentofte Hospital·Phase 4·NCT04830462·32 enrolled

Advanced Solid Tumours1 trial

Study to Assess the Effect of Rifampicin (CYP Inducer) on Blood Levels and Safety of Olaparib in Patients With Advanced Solid Tumours

Completed· AstraZeneca logo

AstraZeneca·Phase 1·NCT01929603·32 enrolled

Empagliflozin1 trial

Drug-interaction Trial in Healthy Subjects With Oral Administration of Empagliflozin (BI 10773), Rifampicin and Probenecid

Completed· Boehringer Ingelheim logo

Boehringer Ingelheim·Phase 1·NCT01634100·18 enrolled

Alzheimer's Disease1 trial

Effects of Doxycycline and Rifampicin on Biomarkers of Alzheimer's Disease in the Cerebrospinal Fluid

Completed·HHamilton Health Sciences Corporation·Phase 3·NCT00439166·100 enrolled

Baricitinib1 trial

A Study of Baricitinib and Rifampicin in Healthy Participants

Completed· Eli Lilly logo

Eli Lilly·Phase 1·NCT01910311·18 enrolled

NSCLC1 trial

Study to Assess the Effect of Rifampicin on Blood Levels and Safety of AZD9291, in Patients With EGFRm+ NSCLC

Completed· AstraZeneca logo

AstraZeneca·Phase 1·NCT02197247·41 enrolled

Tuberculosis (TB)1 trial

Optimal Treatment Duration for Radiographically Apparent, Bacteriologically Unconfirmed TB, Identified Through Active Case Finding

Recruiting·UUniversity College, London·Phase 3·NCT07163143·784 enrolled

Breast Cancer1 trial

A Single-center, Single-arm, Open-label, Fixed-sequence Study to Evaluate the Effect of Rifampin on the Pharmacokinetics of Oral HRS-8080 in Healthy Participants

Not yet recruiting·SShandong Suncadia Medicine Co., Ltd.·Phase 1·NCT07876596·18 enrolled

Solid Tumor1 trial

A Phase 1 Study to Evaluate the C-QTc Interval of QLC5508, Compare the Pharmacokinetics of Two Different Formulations, and Assess Drug-Drug Interaction Potential in Participants With Advanced Solid Tumors

Recruiting· Qilu Pharmaceutical Co., Ltd. logo

Qilu Pharmaceutical Co., Ltd.·Phase 1·NCT07620041·48 enrolled

Tuberculosis Infection1 trial

An Open-label, Randomized Controlled Trial of the New One-month Regimen Versus the Current Three-month Regimen for the Treatment of Tuberculosis Infection in Vietnam

Withdrawn·FFreundeskreis Für Internationale Tuberkulosehilfe e.V·Phase 3·NCT06191692

Severe Acute Malnutrition1 trial

Co-SAM: An Adaptive Multi-arm Trial to Improve Clinical Outcomes Among Children Recovering From Complicated Severe Acute Malnutrition

Completed·QQueen Mary University of London·Phase 3·NCT05994742·674 enrolled

Pediatric HIV Infection1 trial

Mind the Gaps: Pharmacokinetic Research to Advance Pediatric HIV/TB Cotreatment and TB Prevention

Recruiting·BBrigham and Women's Hospital·Phase 1·NCT05069688·20 enrolled

HIV1 trial

A Phase IIc Trial of Clofazimine- and Rifapentine-Containing Treatment Shortening Regimens in Drug-Susceptible Tuberculosis: The CLO-FAST Study

Terminated·NNational Institute of Allergy and Infectious Diseases (NIAID)·Phase 2·NCT04311502·104 enrolled

Unspecified15 trials

Genetic Variability in the Response to Warfarin at Baseline and During Induction of CYP2C9

Unknown status·HHadassah Medical Organization·N/A·NCT01388075·150 enrolled

A Study in Healthy Men to Test Whether Rifampicin Influences the Amount of BI 894416 in the Blood

Completed· Boehringer Ingelheim logo

Boehringer Ingelheim·Phase 1·NCT04060719·16 enrolled

A Study in Healthy Men to Test Whether Rifampicin Influences the Amount of BI 425809 in the Blood

Completed· Boehringer Ingelheim logo

Boehringer Ingelheim·Phase 1·NCT03082183·16 enrolled

Show 12 more trials

The Effect of Intermittent Rifampicin on Raltegravir

Completed·HHelen Reynolds·Phase 1·NCT01424826·18 enrolled

A Study to Investigate the Effect of Rifampicin on the PK of Multiple Doses of Balovaptin In Healthy Volunteers

Completed· Roche logo

Roche·Phase 1·NCT03586726·16 enrolled

A Study in Healthy Male Subjects to Investigate Whether Administration of Rifampicin Can Affect the Fate of Clazosentan in the Body of Clazosentan

Completed· Idorsia Pharmaceuticals Ltd. logo

Idorsia Pharmaceuticals Ltd.·Phase 1·NCT03596294·14 enrolled

Short-term Bactericidal Effect of Contezolid in MAC-PD

Recruiting·BBin Cao·Phase 4·NCT07084402·188 enrolled

A Clinical Study Investigating Rifampicin and Dolutegravir in Combination in Healthy Volunteers

Unknown status·SSt. Stephens Clinical Research·Phase 1·NCT03199690·16 enrolled

Colistin and Rifampicin for MDR-Acinetobacter

Completed·UUniversity of Campania Luigi Vanvitelli·Phase 3·NCT01577862·210 enrolled

A Study to Investigate the Effect of Rifampicin on the Uptake and Breakdown of ACT-246475 in Healthy Subjects

Completed·VViatris Innovation GmbH·Phase 1·NCT03814200·14 enrolled

EBA, Safety and Tolerability of Sanfetrinem Cilexetil

Completed·TTASK Applied Science·Phase 2·NCT05388448·54 enrolled

The Effects of PXR Activation on Hepatic Fat Content

Completed·UUniversity of Oulu·Phase 4·NCT02329405·16 enrolled

Phenotyping of High Dose Rifampicin

Completed·RRadboud University Medical Center·Phase 1·NCT04525235·25 enrolled

A Phase 1, Randomized, Double-blind, Placebo-controlled, Multiple Dose Trial in Healthy Adult Participants to Evaluate the Safety, Tolerability, and Pharmacokinetics of TBD11 With Up to 84-day Period of Fixed Daily Dosing, With an Evaluation of Drug-Drug Interactions

Recruiting·GGates Medical Research Institute·Phase 1·NCT07883226·66 enrolled

A Phase I Study to Evaluate the Effect of D-2570 on the Pharmacokinetics of Midazolam, Digoxin,Rosuvastatin and Metformin, as Well as the Effect of Itraconazole, Rifampicin and Omeprazole on the Pharmacokinetics of D-2570 in Healthy Trial Participants

Not yet recruiting·IInventisBio Co., Ltd·Phase 1·NCT07875842·60 enrolled

Sources

References

[1]
ClinicalTrials.gov — 144 trial records for Rifampicin. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — Rifampicin compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for Rifampicin. EMBL-EBI & Wellcome Sanger Institute.
[4]
SEC EDGAR — Boehringer Ingelheim company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[2]
Highest Phase: Phase 3[1]
Company: Boehringer Ingelheim

Rifampicin

Status by Indication[3][1]

Competitive Landscape

Expected Milestones

Q4 2026

Q1 2027

Trials by Indication[1]

Interaction22 trials

Tics16 trials

Tuberculosis12 trials

Pulmonary Tuberculosis7 trials

Drug Interactions6 trials

Meningitis3 trials

Concentration3 trials

Adult3 trials

Tuberculosis, Pulmonary3 trials

ESS2 trials

Single Dose2 trials

Homeostasis2 trials

Adult Subject2 trials

Methotrexate2 trials

Pulmonary TB2 trials

Fed1 trial

Mycobacterium Avium Complex1 trial

Advanced Cancer1 trial

MPA1 trial

Lung Disease1 trial

Leprosy1 trial

Treatment1 trial

Multiple System Atrophy1 trial

Lymphoma1 trial

Advanced Solid Tumors1 trial

Blood Pressure1 trial

Endocarditis1 trial

Pregnancy1 trial

NAC1 trial

Pilot Study1 trial

Buprenorphine1 trial

Methicillin-resistant Staphylococcus Aureus1 trial

TIA1 trial

Rhinoscleroma1 trial

Mycobacterium Avium Complex Pulmonary Disease1 trial

Elderly1 trial

Trial1 trial

Female1 trial

Apatinib1 trial

Colorectal Cancer1 trial

Oral1 trial

Antibiotic Therapy1 trial

Drug1 trial

Absorption1 trial

Chronic Inflammation1 trial

Advanced Solid Tumours1 trial

Empagliflozin1 trial

Alzheimer's Disease1 trial

Baricitinib1 trial

NSCLC1 trial

Tuberculosis (TB)1 trial

Breast Cancer1 trial

Solid Tumor1 trial

Tuberculosis Infection1 trial

Severe Acute Malnutrition1 trial

Pediatric HIV Infection1 trial

HIV1 trial

Unspecified15 trials

References

Drug Info

Quick Facts

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