Trodelvy

(Sacituzumab)

Phase 3Monoclonal antibody

Sacituzumab is used to treat certain types of cancer, including triple-negative breast cancer and urothelial cancer. It works by targeting cancer cells and delivering a toxic substance directly to them to kill the cancer.[1] Trodelvy is currently being investigated across 28 indications[3], with its most advanced program in Phase 3.[1]

Trodelvy is one of 683 small molecule programs targeting Metastasis. It is currently in Phase 3.

Indications

178

Total Trials

159

Active Trials

682

Competitors

FDA Application

NDA/BLA/ANDA regulatory filings

Pipeline

Status by Indication[3][1]

Indication

MetastasisActive, not recruiting

Esophageal Squamous Cell CarcinomaActive, not recruiting

Lung CancerActive, not recruiting

Esophageal CancerActive, not recruiting

Gastric AdenocarcinomaActive, not recruiting

Thymic CarcinomaActive, not recruiting

Intestinal CancerActive, not recruiting

MesotheliomaActive, not recruiting

Triple-Negative Breast CancerActive, not recruiting

Cervical CarcinomaActive, not recruiting

MetastasisPhase 2

Active, not recruiting

Esophageal Squamous Cell CarcinomaPhase 2

Active, not recruiting

Lung CancerPhase 2

Active, not recruiting

Esophageal CancerPhase 1/Phase 2

Active, not recruiting

Gastric AdenocarcinomaPhase 1/Phase 2

Active, not recruiting

Thymic CarcinomaPhase 2

Active, not recruiting

Intestinal CancerPhase 1/Phase 2

Active, not recruiting

MesotheliomaPhase 2

Active, not recruiting

Triple-Negative Breast CancerPhase 1

Active, not recruiting

Cervical CarcinomaPhase 2

Active, not recruiting

Showing 10 of 28 indications

Competition

Competitive Landscape

2828 competitors in Breast Cancer

#DrugCompanyPhaseTrials

Trodelvy

Gilead

Phase 3

37 2

Tecentriq

Roche

Preclinical

36 3

DATROWAY

Daiichi Sankyo

Preclinical

4 4

Cymbalta

Alnylam Pharmaceuticals

Preclinical

3 5

Zolymbus

AbbVie

Preclinical

1 6

Recentin

NNational Cancer Institute (NCI)

Preclinical

2 7

Acupan

YYonsei University

Preclinical

1 8

Chantix

PPrism Pharmaceuticals

Preclinical

1 9

Avastin

Roche

Preclinical

4 10

Paracetamol

GSK

Preclinical

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q3 2026

Phase 2Recruiting

Glioblastoma

NCT04559230

Phase 2Active, not recruiting

Lung Cancer

NCT05186974

Q4 2026

Phase 2Active, not recruiting

Solid Tumor

NCT05119907

Phase 2Active, not recruiting

Cholangiocarcinoma

NCT06178588

Phase 2Recruiting

Antibody

NCT06263543

Phase 2Active, not recruiting

Metastatic Solid Tumors

NCT03964727

Clinical

Trials by Indication[1]

Breast Cancer37 trials

Study of Sacituzumab Govitecan With Atropine to Improve Tolerability in Advanced TNBC and HR+/HER2- Breast Cancer

Not yet recruiting·MMedSIR·Phase 2·NCT07367178·30 enrolled

Sequential Therapies Modeled on Evolutionary Dynamics for Breast Cancer

Recruiting·HH. Lee Moffitt Cancer Center and Research Institute·Phase 2·NCT06409390·15 enrolled

A Single-arm Phase II Trial of SAcituzumab Govitecan and Trastuzumab for HER2+ Metastatic Breast Cancer After Trastuzumab dEruxtEcaN (SATEEN)

Active, not recruiting·—·Phase 2·NCT06100874·28 enrolled

Show 34 more trials

YL202 Versus Treatment of Physician's Choice in Patients With HR+/HER2- Breast Cancer

Not yet recruiting·MMediLink Therapeutics (Suzhou) Co., Ltd.·Phase 3·NCT07461454·376 enrolled

Study of Sacituzumab Govitecan-hziy and Pembrolizumab Versus Treatment of Physician's Choice in Patients With Triple Negative Breast Cancer Who Have Residual Invasive Disease After Surgery and Neoadjuvant Therapy (ASCENT-05/AFT-65 OptimICE-RD/GBG 119/NSABP B-63)

Recruiting· Gilead logo

Gilead·Phase 3·NCT05633654·1,514 enrolled

Study of Sacituzumab Govitecan Versus Treatment of Physician's Choice in Patients With Hormone Receptor-positive/Human Epidermal Growth Factor Receptor 2 Negative (HR+/HER2-) Metastatic Breast Cancer Who Have Received Endocrine Therapy

Active, not recruiting· Gilead logo

Gilead·Phase 3·NCT05840211·654 enrolled

Sacituzumab Tirumotecan Plus Tagitanlimab in Previously Treated Locally Advanced or Metastatic Triple Negative Breast Cancer

Not yet recruiting·TTianjin Medical University Cancer Institute and Hospital·Phase 2·NCT07153965·47 enrolled

HR+/HER2- Advanced or Metastatic Breast Cancer Patients Treated With Sacituzumab Govitecan

Recruiting·SSOLTI Breast Cancer Research Group·Phase 2·NCT06236269·50 enrolled

Study of Sacituzumab Govitecan-hziy Versus Treatment of Physician's Choice in Participants With HR+/HER2- Metastatic Breast Cancer

Completed· Gilead logo

Gilead·Phase 3·NCT03901339·543 enrolled

Evaluation of Trop-2 ADC in Breast Cancer Patients With Brain Metastases: A Real-World Study

Recruiting·PPeking University Cancer Hospital & Institute··NCT07251868·100 enrolled

A Trial to Evaluate Sacituzumab Govitecan in Combination With Endocrine Therapy in Patients With HR-positive, HER2-negative Metastatic Breast Cancer Progressed on CDK4/6 Inhibitors

Not yet recruiting·HHunan Cancer Hospital·Phase 1·NCT07163481·12 enrolled

Real-world Effectiveness and Safety Study of Sacituzumab Govitecan in Chinese Metastatic Breast Cancer

Recruiting·FFudan University··NCT06356519·150 enrolled

Study to Evaluate Sacituzumab Govitecan in Combination With Talazoparib in Patients With Metastatic Breast Cancer.

Active, not recruiting·MMassachusetts General Hospital·Phase 1/2·NCT04039230·75 enrolled

Organoid-based Functional Precision Therapy for Advanced Breast Cancer

Recruiting·GGuangdong Provincial People's Hospital·Phase 2·NCT06102824·252 enrolled

Genomic and Transcriptomic Predictors of Sequential SG Sensitivity After T-DXd in ER+/HER2-Low Metastatic Breast Cancer

Recruiting·BBritish Columbia Cancer Agency·Phase 2·NCT06665178·20 enrolled

Safety and Efficacy Analysis of an Antibody Associated With a Chemotherapy for Patients With a Triple Negative Metastatic Breast Cancer

Recruiting·UUNICANCER·Phase 3·NCT05552001·96 enrolled

HCQ+ADC vs ADC in the Treatment of Advanced Breast Cancer

Recruiting·SSun Yat-Sen Memorial Hospital of Sun Yat-Sen University·Phase 1/2·NCT06328387·120 enrolled

A Study Evaluating the Efficacy and Safety of Multiple Treatment Combinations in Patients With Metastatic or Locally Advanced Breast Cancer

Recruiting· Roche logo

Roche·Phase 1/2·NCT03424005·792 enrolled

Preventive stRategy for IMMU132-relatED AEs in TNBC or Luminal Breast Cancer- PRIMED

Completed·MMedSIR·Phase 2·NCT05520723·50 enrolled

Sacituzumab Govitecan + Toripalimab as First - Line Therapy for Advanced Triple - Negative Breast Cancer and Biomarker Exploration

Recruiting·PPeking University Cancer Hospital & Institute··NCT06991790·51 enrolled

Avelumab With Binimetinib, Sacituzumab Govitecan, or Liposomal Doxorubicin in Treating Stage IV or Unresectable, Recurrent Triple Negative Breast Cancer

Recruiting·LLaura Huppert, MD, BA·Phase 2·NCT03971409·150 enrolled

Prevention of Sacituzumab Govitecan-related Neutropenia in Patients With Metastatic Triple Negative Breast Cancer

Recruiting·YYeon Hee Park·Phase 2·NCT06616987·40 enrolled

Genomics Guided Targeted Post-neoadjuvant Therapy in Patients With Early Breast Cancer (COGNITION-GUIDE)

Recruiting·GGerman Cancer Research Center·Phase 2·NCT05332561·240 enrolled

NeoAdjuvant Therapy Comparing Sacituzumab Govitecan+Pembrolizumab vs. SoC Chemotherapy in Clinical Stage II-III, Triple-negative Early Breast Cancer

Not yet recruiting·WWest German Study Group·Phase 3·NCT07178730·765 enrolled

Trilaciclib in Patients Receiving Sacituzumab Govitecan-hziy for Triple Negative Breast Cancer

Terminated·GG1 Therapeutics, Inc.·Phase 2·NCT05113966·30 enrolled

Real-world Study of Sacituzumab Govitecan Monotherapy or Combination Therapy in Recurrent or Metastatic HER2-negative Breast Cancer

Active, not recruiting·PPeking University Cancer Hospital & Institute··NCT07018427·70 enrolled

Testing Sacituzumab Govitecan Therapy in Patients With HER2-Negative Breast Cancer and Brain Metastases

Active, not recruiting·SSWOG Cancer Research Network·Phase 2·NCT04647916·44 enrolled

Sacituzumab Govitecan and Zimberelimab w/SRS in the Management of Metastatic Triple Negative Breast Cancer With Brain Metastases

Recruiting·HH. Lee Moffitt Cancer Center and Research Institute·Phase 1/2·NCT06238921·31 enrolled

Alpelisib And Sacituzumab Govitecan For Treatment Of Breast Cancer

Active, not recruiting·UUniversity of Kansas Medical Center·Phase 1·NCT05143229·18 enrolled

Sacituzumab Govitecan in Primary HER2-negative Breast Cancer

Active, not recruiting·GGBG Forschungs GmbH·Phase 3·NCT04595565·1,332 enrolled

Sequencing SG vs. T-DXd in HER2-Low/TROP2-High Metastatic Breast Cancer

Not yet recruiting·FFudan University·Phase 2·NCT07368543·216 enrolled

Sacituzumab Govitecan and Intrathecal Chemotherapy for Treating Leptomeningeal Metastases From Her2-negative Breast Cancer

Recruiting·GGuangzhou Medical University·Phase 1/2·NCT06462092·34 enrolled

SKB264 Combined With KL-A167 Neoadjuvant Therapy for Early-stage, High-risk ER+/HER2- Breast Cancer

Not yet recruiting·WWest China Hospital·Phase 2·NCT07109284·55 enrolled

Sacituzumab Tirumotecan Plus Anlotinib for Metastatic Triple Negative Breast Cancer

Not yet recruiting·TTianjin Medical University Cancer Institute and Hospital·Phase 1/2·NCT07139470·59 enrolled

Asian Study of Sacituzumab Govitecan (IMMU-132) in HR+/HER2- Metastatic Breast Cancer (MBC)

Active, not recruiting· Gilead logo

Gilead·Phase 3·NCT04639986·331 enrolled

Study on Using TROP2-PET and 18F-FDG PET to Predict the Efficacy of Anti TROP2 ADC Treatment in Advanced Breast Cancer

Recruiting·FFudan University·Phase 2·NCT07471776·45 enrolled

Sacituzumab Govitecan Combined With Head Radiotherapy for Her2-negative Breast Cancer Brain Metastases

Not yet recruiting·GGuangzhou Medical University·Phase 2·NCT06462079·43 enrolled

Triple-Negative Breast Cancer12 trials

Trial of Sacituzumab Govitecan in Participants With Refractory/Relapsed Metastatic Triple-Negative Breast Cancer (TNBC)

Completed· Gilead logo

Gilead·Phase 3·NCT02574455·529 enrolled

First-Line Sacituzumab Govitecan in Advanced Untreated Triple-Negative Breast Cancer Patients.

Not yet recruiting·NNathalie Levasseur·Phase 2·NCT07299409·24 enrolled

A Phase II Study of Neoadjuvant Sacituzumab Govitecan and Pembrolizumab Therapy for Immunochemotherapy-resistant Early-stage Triple-negative Breast Cancer (TNBC)

Active, not recruiting·MM.D. Anderson Cancer Center·Phase 2·NCT05675579·27 enrolled

Show 9 more trials

A Study of Sacituzumab With Chemoimmunotherapy to Treat Advanced Triple-Negative Breast Cancer After Prior Therapies

Terminated·IImmunityBio, Inc.·Phase 1/2·NCT04927884·3 enrolled

Study of Sacituzumab Govitecan-hziy and Pembrolizumab Versus Treatment of Physician's Choice and Pembrolizumab in Patients With Previously Untreated, Locally Advanced Inoperable or Metastatic Triple-Negative Breast Cancer

Active, not recruiting· Gilead logo

Gilead·Phase 3·NCT05382286·443 enrolled

Study of Sacituzumab Govitecan-hziy Versus Treatment of Physician's Choice in Patients With Previously Untreated Locally Advanced Inoperable or Metastatic Triple-Negative Breast Cancer

Active, not recruiting· Gilead logo

Gilead·Phase 3·NCT05382299·623 enrolled

A Study of Sacituzumab Govitecan Given at an Alternative Dose and Schedule in Participants With Advanced Triple-Negative Breast Cancer

Recruiting· Gilead logo

Gilead·Phase 1/2·NCT06926920·100 enrolled

Testing Two Different Drugs (Sacituzumab-govitecan and Trastuzumab-deruxtecan) Combinations Prescribed in an Alterning Pattern to Patients With Metastatic or Locally Advanced Triple-negative Breast Cancer

Not yet recruiting·UUNICANCER·Phase 2·NCT07151586·260 enrolled

Study of Sacituzumab Govitecan in Chinese Patients With Metastatic Triple-negative Breast Cancer Who Received at Least Two Prior Treatments

Active, not recruiting· Gilead logo

Gilead·Phase 2·NCT04454437·80 enrolled

Study of Magrolimab Combination Therapy in Patients With Non-Surgically Removable Locally Advanced or Metastatic Triple-Negative Breast Cancer

Terminated· Gilead logo

Gilead·Phase 2·NCT04958785·92 enrolled

A Prospective, Single-center, Phase II Study of Sacituzumab Tirumotecan in Combination With Pembrolizumab for Neoadjuvant Treatment of Triple-Negative Breast Cancer (TNBC)

Not yet recruiting·YYantai Yuhuangding Hospital·Phase 2·NCT07054242·52 enrolled

A Phase 3, Randomized, Open-label, Study to Compare the Efficacy and Safety of Adjuvant MK-2870 in Combination With Pembrolizumab (MK-3475) Versus Treatment of Physician's Choice (TPC) in Participants With Triple-Negative Breast Cancer (TNBC) Who Received Neoadjuvant Therapy and Did Not Achieve a Pathological Complete Response (pCR) at Surgery

Recruiting· Merck & Co. logo

Merck & Co.·Phase 3·NCT06393374·1,530 enrolled

Non-Small Cell Lung Cancer11 trials

Sac-TMT Plus Bevacizumab as Second-Line Treatment for Advanced Non-Squamous Non-Small Cell Lung Cancer

Not yet recruiting·TTianjin Medical University Cancer Institute and Hospital·Phase 2·NCT07244926·31 enrolled

A Clinical Study of MK-1084 With Other Treatments for Non-small Cell Lung Cancer (MK-3475-01F)

Recruiting· Merck & Co. logo

Merck & Co.·Phase 1/2·NCT07286149·190 enrolled

Treatment for Advanced Non-small Cell Lung Cancer With Actionable Genomic Alterations After Targeted Treatment and Chemotherapy (An Expanded Lung-MAP Treatment Trial)

Not yet recruiting·SSWOG Cancer Research Network·Phase 2·NCT07393555·117 enrolled

Show 8 more trials

Study of Pembrolizumab (MK-3475) Monotherapy Versus Sacituzumab Govitecan in Combination With Pembrolizumab for Participants With Metastatic Non-small Cell Lung Cancer (NSCLC) With Programmed Cell Death Ligand 1 (PD-L1) Tumor Proportion Score (TPS) ≥50% (MK-3475-D46)

Active, not recruiting· Merck & Co. logo

Merck & Co.·Phase 3·NCT05609968·614 enrolled

Neoadjuvant Sacituzumab Govitecan Plus Pembrolizumab in Resectable Non-Small Cell Lung Cancer

Recruiting·—·Phase 2·NCT06055465·37 enrolled

Neoadjuvant Sacituzumab Tirumotecan and Limertinib for Potentially Resectable Stage Ⅲ EGFR-mutant Non-small Cell Lung Cancer

Recruiting·SShanghai Pulmonary Hospital, Shanghai, China·Phase 2·NCT07323056·36 enrolled

Sacituzumab Tirumotecan (MK-2870) Versus Chemotherapy in Previously Treated Advanced or Metastatic Nonsquamous Non-small Cell Lung Cancer (NSCLC) With EGFR Mutations or Other Genomic Alterations (MK-2870-004)

Recruiting· Merck & Co. logo

Merck & Co.·Phase 3·NCT06074588·556 enrolled

Phase II Study of Sacituzumab Tirumotecan in Combination With Osimertinib or Sacituzumab Tirumotecan for Neoadjuvant Treatment in Patients With Resectable Epidermal Growth Factor Receptor (EGFR)-Mutated Non-Small Cell Lung Cancer

Not yet recruiting·SSichuan Kelun-Biotech Biopharmaceutical Co., Ltd.·Phase 2·NCT07329322·60 enrolled

Study of Sacituzumab Govitecan (SG) Versus Docetaxel in Participants With Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC)

Active, not recruiting· Gilead logo

Gilead·Phase 3·NCT05089734·603 enrolled

A Study Of Multiple Immunotherapy-Based Treatment Combinations In Participants With Metastatic Non-Small Cell Lung Cancer (Morpheus- Non-Small Cell Lung Cancer)

Completed· Roche logo

Roche·Phase 1/2·NCT03337698·314 enrolled

A Phase 3 Randomized Open-Label Study of Adjuvant Pembrolizumab With or Without MK-2870 in Participants With Resectable Stage II to IIIB (N2) NSCLC Not Achieving pCR After Receiving Neoadjuvant Pembrolizumab With Platinum-based Doublet Chemotherapy Followed by Surgery

Recruiting· Merck & Co. logo

Merck & Co.·Phase 3·NCT06312137·780 enrolled

Bladder Cancer7 trials

PeRioperative Immunotherapy Combined With Sacituzumab Govitecan in Muscle Invasive blAdder Cancer

Active, not recruiting·FFundación para el Progreso de la Oncología en Cantabria·Phase 2·NCT06133517·70 enrolled

Sacituzumab Govitecan Before Radical Cystectomy for the Treatment of Non-Urothelial Muscle Invasive Bladder Cancer

Recruiting·UUniversity of Washington·Phase 2·NCT05581589·18 enrolled

Adaptive RADiation Therapy With Concurrent Sacituzumab Govitecan (SG) for Muscle Invasive Bladder Cancer

Recruiting·—·Phase 1·NCT05833867·20 enrolled

Show 4 more trials

Sacituzumab Govitecan, Preceding Radical Cystectomy, in Treating Patients With Muscle-invasive Bladder Cancer

Recruiting·IIRCCS San Raffaele·Phase 2·NCT05226117·44 enrolled

Bladder Preservation With Sacituzumab Govitecan + Zimberelimab for Muscle-Invasive Bladder Cancer

Not yet recruiting·FFondazione IRCCS Istituto Nazionale dei Tumori, Milano·Phase 2·NCT06528483·63 enrolled

Drug Screening Using IMD in Bladder Cancer

Unknown status·—·Phase 1·NCT06204614·18 enrolled

A Phase 3, Randomized, Open-label Study of Sacituzumab Tirumotecan (MK-2870) Versus Investigator's Choice of Non-platinum Chemotherapy in Participants With Pretreated Locally Advanced/Metastatic Urothelial Carcinoma

Recruiting· Merck & Co. logo

Merck & Co.·Phase 3·NCT07419295·590 enrolled

Urothelial Carcinoma5 trials

Adjuvant Sacituzumab Govitecan and Nivolumab in Muscle-Invasive Urothelial Carcinoma At High-Risk Recurrence

Recruiting·UUniversity of California, Irvine·Phase 2·NCT06682728·23 enrolled

A Study of Efficacy and Safety of Sacituzumab Tirumotecan (MK-2870) Plus Enfortumab Vedotin (EV) With and Without Pembrolizumab in Advanced Urothelial Carcinoma (MK-3475-04C/KEYMAKER-U04)

Active, not recruiting· Merck & Co. logo

Merck & Co.·Phase 1/2·NCT06483334·38 enrolled

Combination of Ipi/Nivo Plus Sacituzumab Govitecan in Metastatic Cisplatin Ineligible Urothelial Carcinoma Patients

Active, not recruiting·HH. Lee Moffitt Cancer Center and Research Institute·Phase 1/2·NCT04863885·46 enrolled

Show 2 more trials

Study Evaluating the Efficacy and Safety of Multiple Immunotherapy-Based Treatments and Combinations in Patients With Urothelial Carcinoma (MORPHEUS-UC)

Completed· Roche logo

Roche·Phase 1/2·NCT03869190·272 enrolled

A Study of the Safety and Efficacy of Various Combinations of Avelumab as Therapy in Locally Advanced or Metastatic Urothelial Carcinoma (JAVELIN Bladder Medley)

Active, not recruiting· EMD Serono Research & Development Institute, Inc. logo

EMD Serono Research & Development Institute, Inc.·Phase 2·NCT05327530·256 enrolled

67 more indications

Cervical Cancer5 trials

SKB264 Plus QL1706 in Recurrent or Metastatic Cervical Cancer

Not yet recruiting·FFujian Cancer Hospital·Phase 2·NCT07256236·89 enrolled

A Study of Sacituzumab Govitecan (IMMU-132) in Patients With Recurrent or Persistent Cervical Cancer

Recruiting·YYale University·Phase 2·NCT05838521·20 enrolled

A Phase II Study of Neoadjuvant Sacituzumab Tirumotecan in Combination With Iparomlimab and Tuvonralimab in Locally Advanced Cervical Cancer

Not yet recruiting·ZZheng Min·Phase 2·NCT07348861·25 enrolled

Show 2 more trials

A Study to Compare Sacituzumab Tirumotecan (MK-2870) Monotherapy Versus Treatment of Physician's Choice as Second-line Treatment for Participants With Recurrent or Metastatic Cervical Cancer (MK-2870-020/TroFuse-020/Gog-3101/ENGOT-cx20)

Recruiting· Merck & Co. logo

Merck & Co.·Phase 3·NCT06459180·686 enrolled

A Phase 3, Randomized, Open-label, Multicenter Study to Evaluate the Efficacy and Safety of Sacituzumab Tirumotecan (MK-2870) in Combination With Pembrolizumab With or Without Bevacizumab Compared With Standard of Care as Firstline Maintenance Treatment for Participants With Persistent, Recurrent, or Newly Diagnosed Metastatic Cervical Cancer With PD-L1 CPS Greater Than or Equal to 1 (TroFuse-036/GOG-3123/ENGOT-cx22)

Recruiting· Merck & Co. logo

Merck & Co.·Phase 3·NCT07216703·1,023 enrolled

Esophageal Squamous Cell Carcinoma4 trials

A Single-center, Multicohort, Phase II Clinical Study Evaluating the Combination Therapy of Sacituzumab Tirumotecan in Patients With Unresectable, Locally Advanced, Recurrent, or Metastatic Esophageal Squamous Cell Carcinoma

Not yet recruiting·TThe First Affiliated Hospital of Zhengzhou University·Phase 2·NCT07128693·60 enrolled

Sacituzumab Govitecan for Advanced Esophageal Squamous Cell Carcinoma

Recruiting·NNational Taiwan University Hospital·Phase 2·NCT06329869·35 enrolled

A Phase 1/2 Open-Label, Umbrella Platform Design Study of Investigational Agents in Combination With Pembrolizumab (MK-3475) With or Without Chemotherapy in Participants With 1L Locally Advanced Unresectable/Metastatic Esophageal Cancer: KEYMAKER-U06 Substudy 06E

Recruiting· Merck & Co. logo

Merck & Co.·Preclinical·NCT06780111·298 enrolled

Show 1 more trial

A Phase 1/2 Open-Label, Umbrella Platform Design Study of Investigational Agents With or Without Pembrolizumab (MK-3475) and/or Chemotherapy in Participants With Advanced Esophageal Cancer Previously Exposed to PD-1/PD-L1 Treatment (KEYMAKER-U06): Substudy 06B

Recruiting· Merck & Co. logo

Merck & Co.·Preclinical·NCT05319730·230 enrolled

Sacituzumab Tirumotecan4 trials

Sacituzumab Tirumotecan and Toripalimab in the First-line Treatment of HNSCC

Recruiting·SShanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University·Phase 2·NCT07088211·39 enrolled

Sacituzumab Tirumotecan (MK-2870) as Monotherapy and in Combination With Pembrolizumab in Participants With Advanced Solid Tumors (MK-2870-008)

Active, not recruiting· Merck & Co. logo

Merck & Co.·Phase 1·NCT06049212·30 enrolled

Sacituzumab Tirumotecan Plus Anlotinib in Previously Treated ES-SCLC

Not yet recruiting·—·Phase 2·NCT07388875·30 enrolled

Show 1 more trial

Sacituzumab Tirumotecan in Neoadjuvant Treatment of Early-Stage TNBC

Not yet recruiting·XXijing Hospital·Phase 2·NCT07007780·35 enrolled

Endometrial Cancer4 trials

Sacituzumab Tirumotecan (MK-2870) in Post Platinum and Post Immunotherapy Endometrial Cancer (MK-2870-005)

Active, not recruiting· Merck & Co. logo

Merck & Co.·Phase 3·NCT06132958·710 enrolled

Study of Sacituzumab Govitecan Versus Treatment of Physician's Choice in Participants With Endometrial Cancer After Platinum-Based Chemotherapy and Immunotherapy (ASCENT-GYN-01/GOG-3104/ENGOT-en26)

Active, not recruiting· Gilead logo

Gilead·Phase 3·NCT06486441·640 enrolled

Sacituzumab Govitecan in Combination With Cisplatin in Platinum Sensitive Recurrent Ovarian and Endometrial Cancer

Recruiting·IIcahn School of Medicine at Mount Sinai·Phase 1/2·NCT06040970·54 enrolled

Show 1 more trial

A Phase 3 Randomized, Open-label, Multicenter Study to Compare the Efficacy and Safety of Sacituzumab Tirumotecan (Sac-TMT, MK-2870) in Combination With Pembrolizumab Versus Pembrolizumab Alone as First-line Maintenance Treatment in Participants With Mismatch Repair Proficient Endometrial Cancer (TroFuse-033/GOG-3119/ENGOT-en29)

Recruiting· Merck & Co. logo

Merck & Co.·Phase 3·NCT06952504·1,123 enrolled

Lung Cancer4 trials

Study of Treatment With Sacituzumab and Zimberelimab for Patients With Lung Cancer Confined to the Chest and Previously Operated on Who Were Not Disease-free.

Recruiting·FFundación GECP·Phase 3·NCT06431633·129 enrolled

Study of Novel Treatment Combinations in Patients With Lung Cancer

Recruiting· Gilead logo

Gilead·Phase 2·NCT05633667·270 enrolled

Study of Sacituzumab Govitecan Combinations in First-line Treatment of Participants With Advanced or Metastatic Non-Small-Cell Lung Cancer (NSCLC)

Active, not recruiting· Gilead logo

Gilead·Phase 2·NCT05186974·193 enrolled

Show 1 more trial

SG and Immunotherapy as Maintenance Therapy for Extensive-stage Small-cell Lung Cancer

Recruiting·BBindu R Potugari·Phase 2·NCT07339059·35 enrolled

Pembrolizumab3 trials

Sacituzumab Govitecan +/- Pembrolizumab in Metastatic TNBC

Recruiting·—·Phase 2·NCT04468061·110 enrolled

Sacituzumab Govitecan +/- Pembrolizumab In HR+ / HER2 - MBC

Active, not recruiting·—·Phase 2·NCT04448886·110 enrolled

NeoAdj. Therapy Comparing Sacituzumab Govitecan (SG) vs. SG+Pembrolizumab in Low-risk, Triple-neg. EBC (ADAPT-TN-III)

Recruiting·WWest German Study Group·Phase 3·NCT06081244·348 enrolled

Ovarian Cancer3 trials

Prospective, Multicenter, Single-Arm, Phase Ⅱ Clinical Study on the Efficacy and Safety of Sacituzumab Tirumotecan Combined With Bevacizumab in Platinum-Resistant Recurrent Ovarian Cancer

Not yet recruiting·TThe First Affiliated Hospital of Zhengzhou University·Phase 2·NCT07314619·30 enrolled

A Study of Sacituzumab Govitecan (IMMU-132) in Platinum-resistant Ovarian Cancer Patients

Active, not recruiting·YYale University·Phase 2·NCT06028932·20 enrolled

A Phase 3, Randomized, Open-label, Multicenter Study to Evaluate the Efficacy and Safety of Sacituzumab Tirumotecan Maintenance Treatment With or Without Bevacizumab Versus Standard of Care After Second-line Platinum-based Doublet Chemotherapy in Participants With Platinum-sensitive Recurrent Ovarian Cancer (TroFuse-022/ENGOT-ov84/GOG-3103)

Recruiting· Merck & Co. logo

Merck & Co.·Phase 3·NCT06824467·770 enrolled

Thyroid Cancer3 trials

Sacituzumab Govitecan in Metastatic Salivary Gland and Thyroid Cancers (SG-SGTC)

Recruiting·NNational University Hospital, Singapore·Phase 2·NCT06923826·32 enrolled

Sacituzumab Tirumotecan Combined With Immunotherapy in Advanced Thyroid Cancer

Recruiting·ZZhejiang Provincial People's Hospital·N/A·NCT07068542·94 enrolled

Sacituzumab govitEcan in THYroid Cancers

Recruiting·GGrupo Espanol de Tumores Neuroendocrinos·Phase 2·NCT06235216·42 enrolled

Solid Tumor3 trials

A Study to Evaluate Rucaparib in Combination With Other Anticancer Agents in Participants With a Solid Tumor (SEASTAR)

Terminated·Ppharmaand GmbH·Phase 1/2·NCT03992131·25 enrolled

Study of Sacituzumab Govitecan in Patients With Solid Tumor

Active, not recruiting· Gilead logo

Gilead·Phase 2·NCT05119907·53 enrolled

A Phase 1/2 Open-Label Study of Sacituzumab Govitecan in Japanese Patients With Advanced Solid Tumors (ASCENT-J02)

Active, not recruiting· Gilead logo

Gilead·Preclinical·NCT05101096·135 enrolled

Esophageal Adenocarcinoma2 trials

Substudy 06C: A Study of Investigational Agents With Pembrolizumab (MK-3475) and Chemotherapy in Participants With First-Line Locally Advanced Unresectable/Metastatic Gastroesophageal Adenocarcinoma (MK-3475-06C/KEYMAKER-U06)

Recruiting· Merck & Co. logo

Merck & Co.·Phase 1/2·NCT06469944·160 enrolled

A Study to Evaluate Sacituzumab Tirumotecan (MK-2870) in Advanced/Metastatic Gastroesophageal Adenocarcinoma (MK-2870-015)

Active, not recruiting· Merck & Co. logo

Merck & Co.·Phase 3·NCT06356311·450 enrolled

Glioblastoma2 trials

Neuro/Sacituzumab Govitecan/Breast Brain Metastasis/Glioblastoma/Ph 0

Completed·TThe University of Texas Health Science Center at San Antonio·Phase 1·NCT03995706·26 enrolled

Sacituzumab Govitecan in Recurrent Glioblastoma

Recruiting·TThe University of Texas Health Science Center at San Antonio·Phase 2·NCT04559230·32 enrolled

Metastatic Solid Tumors2 trials

Study of Sacituzumab Govitecan in Participants With Metastatic Solid Tumors

Active, not recruiting· Gilead logo

Gilead·Phase 2·NCT03964727·223 enrolled

Rollover Study in Participants With Metastatic Solid Tumors Benefiting From Therapy With Sacituzumab Govitecan-hziy

Completed· Gilead logo

Gilead·Phase 4·NCT04319198·25 enrolled

Advanced Solid Tumors2 trials

A Study of Invikafusp Alfa (STAR0602), a Selective T Cell Receptor (TCR)-Targeting, Bifunctional Antibody-fusion Molecule, in Combination With Sacituzumab Govitecan in Participants With Advanced Solid Tumors

Recruiting·MMarengo Therapeutics, Inc.·Phase 1/2·NCT06827613·50 enrolled

Study of GS-0201 Alone and in Combination in Participants With Advanced Solid Tumors

Recruiting· Gilead logo

Gilead·Phase 1·NCT06167317·254 enrolled

Thymic Epithelial Tumors2 trials

A Single-Arm, Phase II Study to Evaluate the Efficacy and Safety of Sacituzumab Tirumotecan in Second-Line and Subsequent Treatments for Advanced Thymic Epithelial Tumors

Not yet recruiting·SSun Yat-sen University·Phase 2·NCT07343453·38 enrolled

A Phase II Trial of Sacituzumab Govitecan in Patients With Advanced Thymic Epithelial Tumors

Recruiting·GGeorgetown University·Phase 2·NCT06248515·18 enrolled

Brain Metastases2 trials

Sacituzumab Govitecan and Bevacizumab for NSCLC Brain Metastases

Recruiting·MMaastricht University Medical Center·Phase 2·NCT06401824·25 enrolled

Sac-TMT for Active TNBC Brain Metastases

Not yet recruiting·YYale University·Phase 2·NCT07458113·20 enrolled

Cholangiocarcinoma2 trials

Sacituzumab Govitecan for the Treatment for Patients With Locally Advanced, Recurrent, or Metastatic Cholangiocarcinoma

Active, not recruiting·UUniversity of Kansas Medical Center·Phase 2·NCT06178588·15 enrolled

Exploring the Safety and Efficacy of Sacituzumab Tirumotecan Combined With Pucotenlimab in the Treatment of Advanced Cholangiocarcinoma

Recruiting·SSir Run Run Shaw Hospital·Phase 2·NCT07105852·59 enrolled

Metastatic2 trials

Phase II Trial of Sacituzumab Govitecan in Recurrent and/or Metastatic Secretory Gland Cancers

Recruiting·MM.D. Anderson Cancer Center·Phase 2·NCT05884320·30 enrolled

Sacituzumab Govitecan Plus EV in Metastatic UC

Recruiting·—·Phase 1/2·NCT04724018·106 enrolled

Prostate Cancer2 trials

Sacituzumab Tirumotecan in Combination With Tagitanlimab in the Treatment of Aggressive Variant Prostate Cancer (AVPC) and Neuroendocrine Prostate Cancer (NEPC)

Recruiting·TTianjin Medical University Second Hospital·Phase 2·NCT07179783·28 enrolled

Sacituzumab Govitecan in Patients With Metastatic Castration-Resistant Prostate Cancer Progressing on Second Generation AR-Directed Therapy

Active, not recruiting·UUniversity of Wisconsin, Madison·Phase 2·NCT03725761·31 enrolled

TNBC2 trials

Saci Nivo Rela for TNBC

Recruiting·YYale University·Phase 1/2·NCT06963905·60 enrolled

Sacituzumab Govitecan In TNBC

Recruiting·MMassachusetts General Hospital·Phase 2·NCT04230109·260 enrolled

Urothelial Cancer2 trials

Study of Sacituzumab Govitecan Versus Physician's Choice of Treatment in Participants With Urothelial Cancer That Cannot Be Removed or Has Spread

Completed· Gilead logo

Gilead·Phase 3·NCT04527991·712 enrolled

Study of Sacituzumab Govitecan in Participants With Urothelial Cancer That Cannot Be Removed or Has Spread

Recruiting· Gilead logo

Gilead·Phase 2·NCT03547973·827 enrolled

Patients With Advanced Solid Tumors2 trials

Study of AVZO-021 in Patients With Advanced Solid Tumors

Recruiting·AAvenzo Therapeutics, Inc.·Phase 1/2·NCT05867251·430 enrolled

Study of DF1001 in Patients With Advanced Solid Tumors

Completed·DDragonfly Therapeutics·Phase 1/2·NCT04143711·270 enrolled

Breast Neoplasms2 trials

A Phase 3, Randomized, Open-label Study to Evaluate the Efficacy and Safety of Sac-TMT (Sacituzumab Tirumotecan, MK-2870) Followed by Carboplatin/Paclitaxel vs Chemotherapy, Both in Combination With Pembrolizumab as Neoadjuvant Therapy for High-Risk, Early-Stage, Triple-Negative Breast Cancer or Hormone Receptor-low Positive/Human Epidermal Growth Factor Receptor-2 Negative Breast Cancer

Recruiting· Merck & Co. logo

Merck & Co.·Phase 3·NCT06966700·2,400 enrolled

An Open-label, Randomized Phase 3 Study of MK-2870 as a Single Agent and in Combination With Pembrolizumab Versus Treatment of Physician's Choice in Participants With HR+/HER2- Unresectable Locally Advanced or Metastatic Breast Cancer

Recruiting· Merck & Co. logo

Merck & Co.·Phase 3·NCT06312176·1,200 enrolled

Non-small Cell Lung Cancer (NSCLC)2 trials

A Randomized, Open-label, Phase 3 Study of MK-2870 vs. Platinum Doublets in Participants With EGFR-mutated, Advanced Nonsquamous Non-small Cell Lung Cancer (NSCLC) Who Have Progressed on Prior EGFR Tyrosine Kinase Inhibitors

Active, not recruiting· Merck & Co. logo

Merck & Co.·Phase 3·NCT06305754·520 enrolled

A Randomized, Open-label, Phase 3 Study of MK-2870 in Combination With Pembrolizumab Compared to Pembrolizumab Monotherapy in the First-line Treatment of Participants With Metastatic Non-small Cell Lung Cancer With PD-L1 TPS Greater Than or Equal to 50% (TroFuse-007)

Recruiting· Merck & Co. logo

Merck & Co.·Phase 3·NCT06170788·614 enrolled

Metastatic Colorectal Cancer1 trial

Sacituzumab Govitecan in Metastatic Colorectal Cancer

Recruiting·UUniversity Hospital Heidelberg·Phase 2/3·NCT06243393·80 enrolled

Antibody1 trial

Sequencing Antibody Drug Conjugates in ER+/HER2 LOW/ULTRA LOW MBC

Recruiting·—·Phase 2·NCT06263543·75 enrolled

Cervical Carcinoma1 trial

Sacituzumab Govitecan for Relapsed Ovarian, Endometrial, and Cervical Carcinomas

Terminated·NNational Cancer Institute (NCI)·Phase 2·NCT06865677·2 enrolled

Advanced or Metastatic Solid Tumor1 trial

Study of Sacituzumab Govitecan in Participants With Advanced or Metastatic Solid Tumor and Moderate Liver Impairment

Recruiting· Gilead logo

Gilead·Phase 1·NCT04617522·30 enrolled

Solid Malignancies1 trial

Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of GS-9716 as Monotherapy and in Combination With Anticancer Therapies in Adults With Solid Malignancies

Active, not recruiting· Gilead logo

Gilead·Phase 1·NCT05006794·145 enrolled

Metastasis1 trial

Sacituzumab Tirumotecan (Sac-TMT) Plus Bevacizumab in 3rd Generation EGFR-TKI Treated Advanced EGFR-mutant Nonsquamous NSCLC With Brain Metastasis

Not yet recruiting·LLi-kun Chen·Phase 2·NCT07197008·50 enrolled

Renal Medullary Carcinoma1 trial

Phase II Trial of Sacituzumab Tirumotecan in Patients With SMARCB1-Deficient Renal Medullary Carcinoma

Not yet recruiting·MM.D. Anderson Cancer Center·Phase 2·NCT07438626·20 enrolled

Gastric Adenocarcinoma1 trial

Study Evaluating Treatment of Sacituzumab-govitecan for Patients With Metastatic Esophagogastric Adenocarcinoma

Completed·IInstitut für Klinische Krebsforschung IKF GmbH at Krankenhaus Nordwest·Phase 1/2·NCT06123468·58 enrolled

Intestinal Cancer1 trial

Sacituzumab Govitecan in Combination With Capecitabine for Advanced Gastrointestinal Cancers After Progression on Standard Therapy

Recruiting·HHenry Ford Health System·Phase 1·NCT06065371·20 enrolled

PD-L1 Positive1 trial

A Study of Sacituzumab Govitecan Plus Toripalimab Versus Toripalimab Plus Nab-Paclitaxel in PD-L1 Positive Advanced TNBC

Not yet recruiting·SSun Yat-Sen Memorial Hospital of Sun Yat-Sen University·Phase 2·NCT07040644·150 enrolled

Advanced1 trial

Trop-2 Targeted PET Probes in Advanced TNBC

Recruiting·PPeking University Cancer Hospital & Institute·N/A·NCT07046455·20 enrolled

Head and Neck Squamous Cell Cancer1 trial

A Study of Sacituzumab Govitecan in Combination With Cetuximab in People With Head and Neck Squamous Cell Cancer (HNSCC)

Recruiting·MMemorial Sloan Kettering Cancer Center·Phase 2·NCT07063212·40 enrolled

Bevacizumab1 trial

Sacituzumab Govitecan Plus Bevacizumab in Metastatic TNBC

Enrolling by invitation·YYING FAN·Phase 2·NCT07359404·60 enrolled

Endometrial Carcinoma1 trial

A Study of Sacituzumab Govitecan (IMMU-132) in Endometrial Carcinoma

Active, not recruiting·YYale University·Phase 2·NCT04251416·50 enrolled

First-line Treatment1 trial

Sac-TMT Combined With Toripalimab for First-line Treatment of PD-L1 Positive a/mTNBC

Not yet recruiting·TTianjin Medical University Cancer Institute and Hospital·Phase 2·NCT07244874·41 enrolled

Small Cell Lung Cancer1 trial

Bispecific T-Cell Engager Tarlatamab and TROP2 Targeted Antibody Drug Conjugate Sacituzumab Govitecan in Previously Treated Extensive-Stage Small Cell Lung Cancer and Extrapulmonary Neuroendocrine Cancer

Not yet recruiting·NNational Cancer Institute (NCI)·Phase 1/2·NCT07328490·120 enrolled

Efficacy and Safety1 trial

Efficacy and Safety of SKB264 in Combination With Pembrolizumab in Patients With Initially Unresectable Stage III NSCLC

Not yet recruiting·HHunan Province Tumor Hospital·Phase 2·NCT06706219·50 enrolled

Advanced or Metastatic Solid Tumors1 trial

Personalized Antibody-Drug Conjugate Therapy Based on RNA and Protein Testing for the Treatment of Advanced or Metastatic Solid Tumors (The ADC MATCH Screening and Treatment Trial)

Recruiting·NNational Cancer Institute (NCI)·Phase 2·NCT06311214·500 enrolled

Advanced or Metastatic NSCLC1 trial

Sacituzumab Tirumotecan in Combination With Furmonertinib as Second-line Treatment for EGFR-mutant Advanced or Metastatic NSCLC After Failure of First-line Third-generation EGFR-TKI Therapy

Not yet recruiting·FFudan University·Phase 2·NCT07193160·45 enrolled

Safety and Efficacy1 trial

Phase II Trial Evaluating the Safety and Efficacy of the Combination of Zimberelimab, Domvanalimab and Sacituzumab Govitecan as 1L Therapy for PD-L1 Positive Advanced TNBC

Not yet recruiting·MMedSIR·Phase 2·NCT07134556·25 enrolled

Head and Neck Squamous Cell Carcinoma1 trial

Neoadjuvant Sacituzumab Govitecan Plus Tagitanlimab for Resectable Head and Neck Squamous Cell Carcinoma

Not yet recruiting·WWest China Hospital·Phase 2·NCT07492914·30 enrolled

Treatment1 trial

Precision Medicine Trial Based on Molecular Matching Therapy for Patients With Standard Treatment Exhaustion

Recruiting·TTianjin Medical University Second Hospital·Phase 2·NCT06739395·300 enrolled

Recurrence1 trial

Atezolizumab + Sacituzumab Govitecan to Prevent Recurrence in TNBC (ASPRIA)

Recruiting·—·Phase 2·NCT04434040·40 enrolled

Thymic Carcinoma1 trial

Sacituzumab Tirumotecan in Participants With Locally Advanced or Metastatic Thymic Carcinoma

Not yet recruiting·SSichuan Kelun-Biotech Biopharmaceutical Co., Ltd.·Phase 2·NCT07324629·30 enrolled

Cancer1 trial

Study of Sacituzumab Govitecan-hziy (IMMU-132) in Adults With Epithelial Cancer

Completed· Gilead logo

Gilead·Phase 1/2·NCT01631552·515 enrolled

Mesothelioma1 trial

A Study of Sacituzumab Govitecan in People With Mesothelioma

Recruiting·MMemorial Sloan Kettering Cancer Center·Phase 2·NCT06477419·33 enrolled

Solid Tumors1 trial

Study of IDE397 in Participants With Solid Tumors Harboring MTAP Deletion

Recruiting·IIDEAYA Biosciences·Phase 1·NCT04794699·180 enrolled

Monotherapy1 trial

P2 Clinical Efficacy & Safety Study of V-111 Monotherapy & Sacituzumab Govitecan-hziy/V-111 Combo Therapy for mTNBC .

Withdrawn·VVeru Inc.·Phase 2·NCT05008510

Toripalimab1 trial

Study of Sacituzumab Govitecan Combined With Toripalimab for Resectable Stage II-IIIB NSCLC

Not yet recruiting·TTianjin Medical University Cancer Institute and Hospital·Phase 2·NCT07438600·38 enrolled

Anatomic Stage IV Breast Cancer AJCC v81 trial

Randomized Phase 2 Clinical Trial of Nab-Paclitaxel + Durvalumab (MEDI4736) + Tremelimumab + Neoantigen Vaccine vs. Nab-Paclitaxel + Durvalumab (MEDI4736) + Tremelimumab in Patients With Metastatic Triple Negative Breast Cancer

Recruiting·NNational Cancer Institute (NCI)·Phase 2·NCT03606967·86 enrolled

Non Muscle Invasive Bladder Cancer1 trial

A Phase 1/2 Open-label Clinical Study to Evaluate the Safety and Efficacy of Intravesical Sacituzumab Tirumotecan (Sac-TMT, MK-2870) in Participants With Intermediate-risk Non-muscle Invasive Bladder Cancer (NMIBC)

Recruiting· Merck & Co. logo

Merck & Co.·Preclinical·NCT06637423·32 enrolled

Triple Negative Breast Neoplasms1 trial

A Phase 3, Randomized, Open-label Study Comparing Efficacy and Safety of Sacituzumab Tirumotecan (Sac-TMT, MK-2870) as a Monotherapy and in Combination With Pembrolizumab (MK-3475) Versus Treatment of Physician's Choice in Participants With Previously Untreated Locally Recurrent Unresectable or Metastatic Triple-Negative Breast Cancer Expressing PD-L1 at CPS Less Than 10 (TroFuse-011)

Recruiting· Merck & Co. logo

Merck & Co.·Phase 3·NCT06841354·1,000 enrolled

Metastatic Triple-negative Breast Cancer1 trial

Phase I/II Study of Naxitamab and Sacituzumab Govitecan in Patients With Metastatic Triple-negative Breast Cancer (TNBC)

Recruiting·MM.D. Anderson Cancer Center·Preclinical·NCT07011654·31 enrolled

Gastroesophageal Adenocarcinoma1 trial

A Phase 1/2 Open-Label, Umbrella Platform Design Study to Evaluate the Safety and Efficacy of Investigational Agents in Combination With Standard of Care Treatments as the Second-Line Treatment of Participants With Advanced/Metastatic Gastroesophageal Adenocarcinoma: Substudy 06D

Recruiting· Merck & Co. logo

Merck & Co.·Preclinical·NCT06445972·210 enrolled

Ovarian Neoplasms1 trial

A Phase 3, Randomized, Open-label, Multicenter Study of Sacituzumab Tirumotecan (Sac-TMT, MK-2870) Maintenance Treatment With or Without Bevacizumab Versus Standard of Care in Participants With Newly Diagnosed Advanced Non-HRD Positive Ovarian Cancer Following First-line Platinum-based Chemotherapy (TroFuse-021/ENGOTov85/GOG-3102)

Recruiting· Merck & Co. logo

Merck & Co.·Phase 3·NCT07318558·900 enrolled

HRD Cancer1 trial

A Phase I/II Study of Sacituzumab Govitecan Plus Berzosertib in Small Cell Lung Cancer, Extra-Pulmonary Small Cell Neuroendocrine Cancer and Homologous Recombination-Deficient Cancers Resistant to PARP Inhibitors

Active, not recruiting·NNational Cancer Institute (NCI)·Preclinical·NCT04826341·35 enrolled

Small Cell Carcinoma1 trial

A Phase II Study of Sacituzumab Govitecan With or Without Atezolizumab Immunotherapy in Rare Genitourinary Tumors (SMART) Such as High Grade Neuroendocrine Carcinomas, Adenocarcinoma, and Squamous Cell Bladder/Urinary Tract Cancer, Renal Medullary Carcinoma and Penile Cancer

Recruiting·NNational Cancer Institute (NCI)·Phase 2·NCT06161532·60 enrolled

Metastatic Bladder Urothelial Carcinoma1 trial

A Phase III Randomized Trial of Eribulin (NSC #707389) With Gemcitabine Versus Standard of Care (Physician's Choice) for Treatment of Metastatic Urothelial Carcinoma Refractory to, or Ineligible for, Anti PD1/PDL1 Therapy

Active, not recruiting·NNational Cancer Institute (NCI)·Phase 3·NCT04579224·184 enrolled

Colorectal Cancer1 trial

A Phase 1/2 Study to Evaluate the Safety and Efficacy of MK-2870 Monotherapy or in Combination With Other Anticancer Agents in Gastrointestinal Cancers

Recruiting· Merck & Co. logo

Merck & Co.·Preclinical·NCT06428409·220 enrolled

Lung Neoplasm Malignant1 trial

KEYMAKER-U01 Substudy 01E: A Phase 2 Umbrella Study With Rolling Arms of Investigational Agents With or Without Chemotherapy in Combination With Pembrolizumab in Treatment of Participants With Newly Diagnosed Resectable Stages II-IIIB (N2) Non-small Cell Lung Cancer (NSCLC)

Recruiting· Merck & Co. logo

Merck & Co.·Phase 2·NCT06788912·60 enrolled

Locally Advanced Urothelial Carcinoma1 trial

A Phase III Randomized Trial of Pembrolizumab in Combination With Sacituzumab Govitean-hziy vs Standard of Care in Anti-PD(L)1-Resistant Advanced Urothelial Cancer

Recruiting·NNational Cancer Institute (NCI)·Phase 3·NCT06524544·320 enrolled

Extensive Stage Small Cell Lung Cancer (ES-SCLC)1 trial

A Global, Multicenter, Randomized, Open-label, Phase 3 Study of Sacituzumab Govitecan Versus Standard of Care (SOC) in Participants With Previously Treated Extensive Stage Small Cell Lung Cancer (ES-SCLC)

Recruiting· Gilead logo

Gilead·Phase 3·NCT06801834·695 enrolled

Metastatic HER2-Negative Breast Carcinoma1 trial

A Randomized Clinical Trial Comparing ctDNA-Directed Therapy Change With Standard of Care in Patients With Metastatic Triple Negative Breast Cancer

Recruiting·VVanderbilt-Ingram Cancer Center·Phase 2·NCT05770531·160 enrolled

Unspecified2 trials

Scalp Cooling in MBC

Recruiting·—·Phase 2·NCT04986579·120 enrolled

StrataPATH™ (Precision Indications for Approved Therapies)

Terminated·SStrata Oncology·Phase 2·NCT05097599·11 enrolled

Regulatory

FDA Approval Timeline[4]

Apr 22, 2020

TRODELVY

BLA BLA761115

Sources

References

[1]
ClinicalTrials.gov — 178 trial records for Sacituzumab. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — Sacituzumab compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for Sacituzumab. EMBL-EBI & Wellcome Sanger Institute.
[4]
OpenFDA — FDA approval records (BLA BLA761115). U.S. Food & Drug Administration.
[5]
SEC EDGAR — Gilead company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Monoclonal antibody[2]
Highest Phase: Phase 3[1]
Company: Gilead