Cardene
(Nicardipine)ApprovedSmall molecule
Sun Pharmaceutical Industries, Inc.Nicardipine is used to lower high blood pressure and to help prevent chest pain caused by heart disease. It works by relaxing blood vessels to improve blood flow and reduce the workload on your heart.[2] Cardene is currently approved and in use across 12 indications[4].[1]
Cardene is one of 239 small molecule programs targeting Cardiovascular Disease. It is currently in Approved.
12
Indications
27
Total Trials
4
Active Trials
238
Competitors
5
FDA Applications
NDA/BLA/ANDA regulatory filings
6
Patents
Pipeline
Status by Indication[4][1]
Indication
Showing 10 of 12 indications
Competition
Competitive Landscape
146 competitors in Cardiovascular Disease
#DrugCompanyPhaseTrials
1Cardene
Sun Pharmaceutical Industries, Inc.Approved
Zyloprim
Jazz PharmaceuticalsApproved
Ephedrine Sulfate
DDr. Reddys Laboratories, SA
Approved
Nimotop
AAzurity Pharmaceuticals
Approved
Micardis
Boehringer IngelheimApproved
Colcrys
Jazz PharmaceuticalsPhase 3
Cagrilintide
Novo NordiskPhase 3
Pelacarsen
NovartisPhase 3
Berberine
XXijing Hospital of Digestive Diseases
Phase 3
Obicetrapib
NNewAmsterdam Pharma
Phase 3
Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.
Timeline
Expected Milestones
Clinical
Trials by Indication[1]
Hypertension3 trials
CAR3 trials
Stroke3 trials
Hypotensive Anesthesia2 trials
Hypotensive Anesthesia for Orthognathic Surgery
Active, not recruiting·—·Phase 4·NCT06093893·90 enrolled
Surgery2 trials
NICardipine Neuroprotection in AortiC Surgery (NICNACS)
Terminated·—·Phase 2·NCT00508118·7 enrolled
Comparison of Remifentanil and Nicardipine Infusions for Controlled Hypotension in Elective Nasal Surgery Where Bleeding Control is Critical: A Randomized Controlled Trial
Not yet recruiting·SSaglik Bilimleri Universitesi Gazi Yasargil Training and Research Hospital·Preclinical·NCT07660562·44 enrolled
14 more indications
Cardiac Surgery1 trial
Aneurysm1 trial
Coronary Microvascular Dysfunction1 trial
Percutaneous Coronary Intervention1 trial
Intravenous1 trial
Hemodynamic1 trial
Effects of Different Kinds of Hypotensive Drugs on Dynamic Hemodynamic Changing in Patients Under Surgeries
Completed·—·N/A·NCT03497351·59 enrolled
Subarachnoid Hemorrhage1 trial
Acute Respiratory Failure1 trial
Regulatory
FDA Approval Timeline[5]
Dec 21, 1988
CARDENE
NDA NDA019488
Jan 30, 1992
CARDENE
NDA NDA019734
Feb 21, 1992
CARDENE SR
NDA NDA020005
Jul 24, 2008
NICARDIPINE HYDROCHLORIDE
NDA NDA022276
Nov 17, 2009
NICARDIPINE HYDROCHLORIDE
NDA NDA078405
Sources
References
- [1]
- [2]MedlinePlus Drug Information — Cardene drug information. U.S. National Library of Medicine, National Institutes of Health.
- [3]
- [4]Open Targets Platform — Drug–disease associations for Nicardipine. EMBL-EBI & Wellcome Sanger Institute.
- [5]
- [6]
- [7]