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Mineral trioxide aggregate

Phase 3Small molecule

JJordan University of Science and Technology

Mineral trioxide aggregate is one of 51 small molecule programs targeting Melatonin. It is currently in Phase 3.

4

Indications

18

Total Trials

3

Active Trials

50

Competitors

Pipeline

Status by Indication[3][1]

Indication

MelatoninRecruiting

Indirect Pulp CapCompleted

ESSRecruiting

Primary TeethActive, not recruiting

MelatoninPreclinical

Recruiting

Indirect Pulp CapPreclinical

Completed

ESSPhase 3

Recruiting

Primary TeethPhase 3

Active, not recruiting

Competition

Competitive Landscape

56 competitors in ESS

#DrugCompanyPhaseTrials

Lexapro

Proamatine

Quviviq

Idorsia Pharmaceuticals Ltd.

Opdualag

Bristol-Myers Squibb

Opdivo

Bristol-Myers Squibb

Darzalex

Johnson & Johnson

Decadron

AAspen Global Incorporated

Revlimid

KKaruna Therapeutics, Inc., a Bristol Myers Squibb company

Kyprolis

VVirionyx Corporation Limited

Mineral trioxide aggregate

JJordan University of Science and Technology

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q4 2026

Post-ApprovalRecruiting

ESS

NCT04863222

Post-ApprovalActive, not recruiting

Primary Teeth

NCT02298504

Clinical

Trials by Indication[1]

Mineral Trioxide Aggregate4 trials

Calcium Hydroxide, Mineral Trioxide Aggregate and Biodentine (Trademark) as Direct Pulp Capping of Permanent Teeth

Completed·UUniversidad de los Andes, Chile·Phase 2/3·NCT02492841·169 enrolled

Effectiveness of Mineral Trioxide Aggregate and Platelet Rich Fibrin Along With Biodentine. .

Completed·MMaharishi Markendeswar University (Deemed to be University)·Phase 4·NCT04773886·60 enrolled

Postoperative Pain Evaluation of Mineral Trioxide Aggregate and Propolis After Pulpotomy in Carious Primary Molars

Unknown status·—·Phase 2·NCT03580135·28 enrolled

Show 1 more trial

Evaluation of Biodentine and Mineral Trioxide Aggregate in Revascularization of Non Vital Immature Anterior Teeth

Completed·—·N/A·NCT03589560·26 enrolled

Pulpotomy3 trials

Pulpotomy Materials in Primary Molars

Completed·SSacide Duman·N/A·NCT07120321·22 enrolled

Success Rate Evaluation of Miniature Pulpotomy With MTA in Primary Molars

Unknown status·MMashhad University of Medical Sciences·Phase 4·NCT02286648·50 enrolled

Pulpotomy Technique Preserving Vitality of Traumatized Anterior Permanent Immature Teeth

Completed·GGihan M Abuelniel ,PhD·Phase 2/3·NCT03838068·33 enrolled

ESS2 trials

Clinical and Radiographic Success of MTA vs Biodentine

Recruiting·GGeisinger Clinic·Phase 4·NCT04863222·646 enrolled

Assessment of a New Apexification Method for Patients Presenting a Non Vital Immature Tooth

Completed·AAssistance Publique - Hôpitaux de Paris·Phase 3·NCT00472173·34 enrolled

Indirect Pulp Cap2 trials

Comparing Two Indirect Pulp Capping Agents for Permanent Teeth

Unknown status·—·N/A·NCT05425368·30 enrolled

Clinical and Radiographic Evaluation of Indirect Pulp Capping in Primary and Permanent Teeth With Different Materials

Completed·—·N/A·NCT03606681·300 enrolled

Melatonin1 trial

Comparative Evaluation of Melatonin Versus MTA on Vital Pulp Therapy in Young Permanent First Molars: An in Vivo Study

Recruiting·SSuez Canal University·N/A·NCT06372561·45 enrolled

6 more indications

ALS1 trial

Effect Of Different Lining Materials in Stepwise Excavation

Unknown status·—·Phase 2·NCT01730287·100 enrolled

Age1 trial

Pulp Capping With Two Different Agents

Completed·OOregon Health and Science University·N/A·NCT00812877·376 enrolled

Primary Teeth1 trial

Vital Pulp Treatment in Primary Teeth

Active, not recruiting·UUniversity of Maryland, Baltimore·Phase 4·NCT02298504·76 enrolled

TED1 trial

Evaluation of Apexogenesis With Human Treated Dentin Matrix in Young Permanent Molars

Completed·Nnora mostafa mohammed abo shanady·Phase 1/2·NCT05830695·20 enrolled

Treatment Outcome1 trial

Treatment Outcome With a Revascularization Protocol Using the Triple Versus Double Antibiotic Paste

Completed·TThe University of Texas Health Science Center at San Antonio·Phase 1·NCT00881491·10 enrolled

Unspecified1 trial

Long-term Evaluation of Direct Pulp Capping

Unknown status·JJordan University of Science and Technology·N/A·NCT03403985·80 enrolled

Sources

References

[1]
ClinicalTrials.gov — 18 trial records for Mineral trioxide aggregate. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — Mineral trioxide aggregate compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for Mineral trioxide aggregate. EMBL-EBI & Wellcome Sanger Institute.
[4]
SEC EDGAR — Jordan University of Science and Technology company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[2]
Highest Phase: Phase 3[1]
Company: JJordan University of Science and Technology

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