Nexium

Pipeline

Status by Indication[3][1]

Competition

Competitive Landscape

DyspepsiaGastroesophageal Reflux DiseaseInsulin SecretionEsophagitisGastritis

99 competitors in Dyspepsia

#DrugCompanyPhaseTrials

1

Lexapro

AbbVie

Phase 3

22

Tofranil

Sanofi

Phase 3

13

Elavil

AstraZeneca

Phase 3

14

Neurontin

VViatris Specialty LLC

Phase 3

15

Pamelor

SSpecgx

Phase 3

16

Domperidone

Johnson & Johnson

Phase 3

37

Nexium

YYooyoung Pharmaceutical Co., Ltd.

Phase 3

18

Xifaxan

SSalix

Phase 2

39

Aciphex

Akero Therapeutics

Phase 2

110

Nereus

VVanda Pharmaceuticals

Phase 2

1Show 24 more competitors

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Clinical

Trials by Indication[1]

Helicobacter Pylori Infection2 trials

Comparison of Daily Single Dose Triple and Conventional Triple Therapies for Helicobacter Pylori Infection

Completed·ZZahra Vahdat Shariatpanahi·Phase 4·NCT02711176·212 enrolled

High Dose Dual Therapy (HDDT) for Eradication of Helicobacter Pylori Infection

Unknown status·RRabin Medical Center·Phase 4·NCT02553083·300 enrolled

Gastric2 trials

Study of 24-hour Intragastric pH Profiles of Esomeprazole 40 mg and Lansoprazole 30 mg in Healthy Volunteer Subjects

Completed·AstraZeneca·Phase 4·NCT00230516·100 enrolled

A Study to Evaluate the Effect on 24-hour, Intragastric pH of RAB ER 50-mg Capsules Compared With Esomeprazole (Nexium) 40 mg Capsules and Rabeprazole (Aciphex) 20-mg Tablets

Completed·Eisai·Phase 1·NCT01153659·90 enrolled

Efficacy and Safety2 trials

Clinical Trial to Assess the Efficacy and Safety of YYD601 in NERD Patients

Completed·YYooyoung Pharmaceutical Co., Ltd.·Phase 3·NCT03967886·170 enrolled

Clinical Trial to Assess the Efficacy and Safety of YYD601 in the Treatment of Esophageal Reflux Disease (ERD)

Completed·YYooyoung Pharmaceutical Co., Ltd.·Phase 3·NCT03943992·170 enrolled

CKD1 trial

A Study to Compare PK, PD and Safety of CKD-381 in Healthy Subjects

Completed·Chong Kun Dang Pharmaceutical·Phase 1·NCT03211143·41 enrolled

Helicobacter Pylori Eradication1 trial

Levofloxacin-containing Therapies In Second Line Helicobacter Pylori Eradication

Completed·—·N/A·NCT02596620·164 enrolled

14 more indications

MACE1 trial

Bioequivalence Study of Esomeprazole From Stomopral 40 mg Capsules Contain Enteric Coated Pellets (Future Pharmaceuticals Industries, Egypt) and Nexium 40 mg Delayed Release Capsules (AstraZeneca Sweden, Product of France)

Completed·GGenuine Research Center, Egypt·Phase 1·NCT05038969·30 enrolled

Dyspepsia1 trial

The Safety and Efficacy of Dexloxiglumide for the Relief of Symptoms of Functional Dyspepsia.

Completed·FForest Laboratories·Phase 2·NCT00303264·48 enrolled

Effectiveness1 trial

A Study To Investigate The Effectiveness Of AH234844 (Lavoltidine) Compared With NEXIUM And Ranitidine.

Completed·GSK·Phase 2·NCT00405119·92 enrolled

Esophagitis1 trial

Endoscopic Evidence of Maintenance of Healing With Oral NEXIUM in Patients 1 to 11 Years Old With Erosive Esophagitis.

Recruiting·AstraZeneca·Phase 3·NCT05267613·50 enrolled

Gastroesophageal Reflux Disease1 trial

Study Comparing Esomeprazole Associated With Sodium Bicarbonate From Eurofarma and Esomeprazole in Treatment of Gastroesophageal Reflux Disease ESOBIC

Withdrawn·EEurofarma Laboratorios S.A.·Phase 3·NCT01471925

Healing1 trial

Comparison of Nexium Versus Secretol in the Healing and Controlling of Symptoms in GERD Patients With Severe EE.

Unknown status·EEffexus Pharmaceutical·Phase 1/2·NCT01129713·40 enrolled

Helicobacter Pylori1 trial

Comparison of Two Novel First-line Anti-Helicobacter Pylori Therapy

Completed·—·N/A·NCT03383003·240 enrolled

Clinical Trial1 trial

PK/PD Clinical Trial of YYD601 in Healthy Adult Male

Completed·YYooyoung Pharmaceutical Co., Ltd.·Phase 1·NCT03558477·30 enrolled

Gastritis1 trial

Safety Trial of Herbal Melanin in Gastritis Patients

Unknown status·KKing Abdullah International Medical Research Center·Phase 2·NCT03428568·132 enrolled

Acid Reflux1 trial

Effect of Acid Reflux on Respiratory Physiology During Exercise in Athletes With GER-Response to Acid Suppression

Terminated·UUniversity of Utah·Phase 1·NCT00444236·31 enrolled

Interaction1 trial

The PK and PD Interaction Between YH4808, Amoxicillin and Clarithromycin in Healthy Subjects

Completed·YYuhan Corporation·Phase 1·NCT01921647·95 enrolled

Insulin Secretion1 trial

The Effect of Nexium and Probiotics on Insulin Secretion and Cardiovascular Risk Factors in Patients With Type 2 Diabetes

Completed·LLise Tarnow·Phase 3·NCT00699426·41 enrolled

Reflux1 trial

Which Supraesophageal Reflux Symptoms Reliably Respond to Proton-Pump-Inhibitor (PPI) Therapy

Completed·MMayo Clinic·N/A·NCT00170001·500 enrolled

Unspecified2 trials

Bioequivalence of Two Formulations of Esomeprazole

Completed·YYung Shin Pharm. Ind. Co., Ltd.·Phase 4·NCT02543606·14 enrolled

Viokase 16, Viokase16 Plus Nexium and Nexium Alone

Terminated·UUniversity of Florida·Phase 1·NCT01142128·12 enrolled

Details

Drug Info

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