Adalat

(NIFEdipine ER)

ApprovedSmall molecule

PPfizer's Upjohn has merged with Mylan to form Viatris Inc.

Adalat is one of 48 small molecule programs targeting Primary Aldosteronism. It is currently in Approved.

Indications

Total Trials

Active Trials

Competitors

FDA Applications

NDA/BLA/ANDA regulatory filings

Pipeline

Status by Indication[3][1]

Indication

Primary AldosteronismActive, not recruiting

Hypertension, Pregnancy-InducedRecruiting

HypertensionActive, not recruiting

Hypertensive Disorder of PregnancyActive, not recruiting

Primary AldosteronismPreclinical

Active, not recruiting

Hypertension, Pregnancy-InducedPreclinical

Recruiting

HypertensionApproved

Active, not recruiting

Hypertensive Disorder of PregnancyPhase 3

Active, not recruiting

Competition

Competitive Landscape

161 competitors in Hypertension

#DrugCompanyPhaseTrials

Adalat

PPfizer's Upjohn has merged with Mylan to form Viatris Inc.

Approved

3 2

Foundayo

Eli Lilly

Phase 3

3 3

Baxfendy

AstraZeneca

Phase 3

3 4

Alka-Seltzer

AAbbott

Phase 3

1 5

HCP1803-3

Hanmi Pharmaceutical Company Limited

Phase 3

1 6

Avastin

Roche

Preclinical

1 7

Winrevair

Alphagan

Deltavit

HHyundai Pharmaceutical Co., LTD.

Preclinical

2 10

Nipride

EExela Pharma Sciences, LLC.

Preclinical

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q2 2029

PreclinicalRecruiting

Hypertension, Pregnancy-Induced

NCT06220721

Clinical

Trials by Indication[1]

Hypertension3 trials

Amlodipine Versus Nifedipine ER for the Management of Postpartum Hypertension

Completed·PPrisma Health-Upstate·Phase 4·NCT04790279·175 enrolled

Labetalol or Nifedipine for Control of Postpartum Hypertension: A Randomized Controlled Trial

Recruiting·NNebraska Methodist Health System·Phase 4·NCT05309460·600 enrolled

Oral Combined Hydrochlorothiazide/Lisinopril Versus Oral Nifedipine for Postpartum Hypertension

Completed·TThe University of Texas Health Science Center, Houston·Phase 4·NCT05049616·70 enrolled

Primary Aldosteronism1 trial

Effect of a Proposed Cav1.3 Inhibitor in Primary Aldosteronism

Completed·QQueen Mary University of London·N/A·NCT05686993·15 enrolled

Postpartum Period1 trial

Comparing Nifedipine and Enalapril in Medical Resources Used in the Postpartum Period

Completed·—·Phase 4·NCT04236258·94 enrolled

Hypertension, Pregnancy-Induced1 trial

Reducing the Risk of Chronic Hypertension and Improving Vascular Function Following Preeclampsia

Recruiting·MMedical College of Wisconsin·Preclinical·NCT06220721·618 enrolled

Hypertensive Disorder of Pregnancy1 trial

Intensive Postpartum Antihypertensive Treatment to Improve Women's Cardiovascular Health (IPAT Study)

Active, not recruiting·MMedical College of Wisconsin·Phase 3·NCT05687344·60 enrolled

Regulatory

FDA Approval Timeline[4]

Jan 1, 1982

PROCARDIA

NDA NDA018482

Nov 27, 1985

ADALAT

NDA NDA019478

Sep 6, 1989

PROCARDIA XL

NDA NDA019684

Apr 21, 1993

ADALAT CC

NDA NDA020198

Sources

References

[1]
ClinicalTrials.gov — 7 trial records for NIFEdipine ER. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — NIFEdipine ER compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for NIFEdipine ER. EMBL-EBI & Wellcome Sanger Institute.
[4]
OpenFDA — FDA approval records (NDA NDA020198). U.S. Food & Drug Administration.
[5]
SEC EDGAR — Pfizer's Upjohn has merged with Mylan to form Viatris Inc. company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[2]
Highest Phase: Approved[1]
Company: PPfizer's Upjohn has merged with Mylan to form Viatris Inc.

Adalat

Status by Indication[3][1]

Competitive Landscape

Expected Milestones

Q2 2029

Trials by Indication[1]

Hypertension3 trials

Primary Aldosteronism1 trial

Postpartum Period1 trial

Hypertension, Pregnancy-Induced1 trial

Hypertensive Disorder of Pregnancy1 trial

FDA Approval Timeline[4]

References

Drug Info

Quick Facts

Related News