Baxfendy

Pipeline

Status by Indication[3][1]

Competition

Competitive Landscape

Heart FailureHypertensionPrimary AldosteronismHyperaldosteronismUncontrolled Hypertension

687 competitors in Heart Failure

#DrugCompanyPhaseTrials

1

Baxfendy

AstraZeneca

Approved

12

Bayer Aspirin

Bayer

Preclinical

23

Brethine

Sanofi

Preclinical

14

Medrol

Pfizer

Preclinical

15

Amidate

Pfizer

Preclinical

16

LCZ696

Novartis

Preclinical

157

Monoferric

PPharmacosmos A/S

Preclinical

58

Activase

Roche

Preclinical

—9

Zemplar

AbbVie

Preclinical

—10

Savaysa

Daiichi Sankyo

Preclinical

—Show 29 more competitors

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Clinical

Trials by Indication[1]

Hypertension4 trials

A Study to Investigate the Efficacy and Safety of Baxdrostat in Participants With Uncontrolled Hypertension on Two or More Medications Including Participants With Resistant Hypertension

Completed·AstraZeneca·Phase 3·NCT06034743·796 enrolled

A Study to Evaluate Cortisol Reserve in Response to Adrenocorticotropic Hormone (ACTH) Stimulation Test Following Baxdrostat Treatment Compared to Placebo in Participants With Uncontrolled Hypertension

Completed·AstraZeneca·Phase 2·NCT06336356·48 enrolled

A Study to Investigate the Effect of Baxdrostat on Ambulatory Blood Pressure in Participants With Resistant Hypertension

Completed·AstraZeneca·Phase 3·NCT06168409·218 enrolled

Show 1 more trial

A Study to Investigate the Efficacy and Safety of Baxdrostat in Participants With Uncontrolled Hypertension on Two or More Medications Including Participants With Resistant Hypertension

Active, not recruiting·AstraZeneca·Phase 3·NCT06344104·326 enrolled

Female1 trial

A Study to Investigate the Pharmacokinetics of Ethinyl Estradiol and Levonorgestrel When Given Alone and in Combination With Baxdrostat in Healthy Females of Non-childbearing Potential

Completed·AstraZeneca·Phase 1·NCT06657105·22 enrolled

Heart Failure1 trial

Phase III Study Investigating Heart Failure and Cardiovascular Death With Baxdrostat in Combination With Dapagliflozin

Recruiting·AstraZeneca·Phase 3·NCT06677060·11,300 enrolled

ART1 trial

A Study to Investigate the Effect on QTcF of Baxdrostat Compared With Placebo, Using Moxifloxacin as a Positive Control, in Healthy Participants

Completed·AstraZeneca·Phase 1·NCT06194032·28 enrolled

Metabolism1 trial

Phase 1 Study to Determine the Metabolism and Clearance of Baxdrostat

Completed·AstraZeneca·Phase 1·NCT05961384·8 enrolled

5 more indications

Tics1 trial

A Study to Investigate the Pharmacokinetics of Baxdrostat When Given Alone and in Combination With Itraconazole in Healthy Participants

Completed·AstraZeneca·Phase 1·NCT06357520·14 enrolled

Hepatic Impairment1 trial

Phase 1 PK Study to Evaluate the PK of CIN-107 in Subjects With Hepatic Impairment

Completed·AstraZeneca·Phase 1·NCT05961397·20 enrolled

Uncontrolled Hypertension1 trial

A Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Effect of Baxdrostat on Ambulatory Blood Pressure in Chinese Participants With Uncontrolled Hypertension on Two or More Antihypertensive Medications Without Diuretics

Not yet recruiting·AstraZeneca·Phase 3·NCT07686120·286 enrolled

Hyperaldosteronism1 trial

A Randomised, Double-Blind, Placebo-Controlled, Parallel-Group Study to Assess the Efficacy and Safety of Baxdrostat in Adult Participants With Primary Aldosteronism

Recruiting·AstraZeneca·Phase 3·NCT07007793·250 enrolled

Unspecified2 trials

Baxdrostat Safety, Tolerability, Pharmacokinetic and Pharmacodynamic Study in a Japanese Population

Completed·AstraZeneca·Phase 1·NCT05966324·41 enrolled

Baxdrostat Bioavailability and Bioequivalence Study

Completed·AstraZeneca·Phase 1·NCT05963009·14 enrolled

Regulatory

FDA Approval Timeline[4]

Details

Drug Info

Patent Landscape[5]

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