PEG-asparaginase

Pipeline

Status by Indication[3][1]

Competition

Competitive Landscape

Acute Lymphoblastic LeukemiaLymphoblastic LymphomaAdult Acute Lymphoblastic Leukemia

148 competitors in Acute Lymphoblastic Leukemia

#DrugCompanyPhaseTrials

1

Oncovin

Eli Lilly

Phase 3

732

Adriamycin

Pfizer

Phase 3

393

Oncaspar

SServier

Phase 3

474

Wellcovorin

EEastern Cooperative Oncology Group

Phase 3

405

Cerubidine

HHikma Pharmaceuticals LLC

Phase 3

426

Elspar

DDutch Childhood Oncology Group

Phase 3

447

Fludara

Sanofi

Phase 3

158

Cellcept

Roche

Phase 3

119

Iclusig

Takeda

Phase 3

1110

Neoral

Novartis

Phase 3

10Show 32 more competitors

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Clinical

Trials by Indication[1]

Acute Lymphoblastic Leukemia10 trials

EZN-3042 Administered With Re-induction Chemotherapy in Children With Relapsed Acute Lymphoblastic Leukemia (ALL)

Terminated·TTherapeutic Advances in Childhood Leukemia Consortium·Phase 1·NCT01186328·6 enrolled

Bortezomib With Chemotherapy for Relapsed Pediatric Acute Lymphoblastic Leukemia (ALL)

Completed·TTherapeutic Advances in Childhood Leukemia Consortium·Phase 1/2·NCT00440726·31 enrolled

Study of Sirolimus With PEG-Asparaginase in Acute Lymphoblastic Leukemia (ALL)

Withdrawn·EEmory University·Phase 1·NCT00957320

Show 7 more trials

TINI 2: Total Therapy for Infants With Acute Lymphoblastic Leukemia II

Recruiting·TTanja Andrea Gruber·Phase 1/2·NCT05848687·90 enrolled

Treatment of Older Adults With Acute Lymphoblastic Leukemia

Completed·MMassachusetts General Hospital·Phase 2·NCT00973752·30 enrolled

Bortezomib and Combination Chemotherapy in Treating Patients With Relapsed or Refractory Acute Lymphoblastic Leukemia

Completed·SStanford University·Phase 2·NCT01769209·18 enrolled

Augmented Berlin-Frankfurt-Munster Therapy Plus Ofatumumab for Young Adults With Acute Lymphoblastic Leukemia or Lymphoblastic Lymphoma

Terminated·MM.D. Anderson Cancer Center·Phase 2·NCT02419469·1 enrolled

Optimization of Therapy in Adult Patients With Newly Diagnosed Acute Lymphoblastic Leukemia or Lymphoblastic Lymphoma by Individualised, Targeted and Intensified Treatment

Completed·GGoethe University·Phase 3·NCT02881086·1,023 enrolled

Augmented Berlin-Frankfurt-Munster (BFM) Therapy for Adolescent/Young Adults With Acute Lymphoblastic Leukemia or Acute Lymphoblastic Lymphoma

Completed·MM.D. Anderson Cancer Center·Phase 2·NCT00866749·120 enrolled

Study of Carfilzomib in Combination With Induction Chemotherapy in Children With Relapsed or Refractory Acute Lymphoblastic Leukemia

Completed·Amgen·Phase 1·NCT02303821·141 enrolled

T-cell acute lymphoblastic leukemia2 trials

Re-Induction Therapy for Relapsed Pediatric T-Cell Acute Lymphoblastic Leukemia or Lymphoma

Terminated·SSt. Jude Children's Research Hospital·Phase 2·NCT02518750·3 enrolled

A Study to Evaluate the Efficacy and Safety of Daratumumab in Pediatric and Young Adult Participants Greater Than or Equal to (>=)1 and Less Than or Equal to (<=) 30 Years of Age With Relapsed/Refractory Precursor B-cell or T-cell Acute Lymphoblastic Leukemia or Lymphoblastic Lymphoma

Completed·Johnson & Johnson·Phase 2·NCT03384654·47 enrolled

Lymphoblastic Lymphoma2 trials

International Cooperative Treatment Protocol for Children and Adolescents With Lymphoblastic Lymphoma

Recruiting·UUniversity Hospital Muenster·Phase 3·NCT04043494·683 enrolled

NHL16: Study For Newly Diagnosed Patients With Acute Lymphoblastic Lymphoma

Completed·SSt. Jude Children's Research Hospital·Phase 2·NCT01451515·23 enrolled

Relapsed/Refractory1 trial

Pevonedistat With VXLD Chemotherapy for Adolescent/Young Adults With Relapsed/Refractory ALL or Lymphoblastic NHL

Completed·—·Phase 1·NCT03349281·6 enrolled

Pediatric ALL1 trial

ABT-751 With Chemotherapy for Relapsed Pediatric ALL

Terminated·TTherapeutic Advances in Childhood Leukemia Consortium·Phase 1/2·NCT00439296·9 enrolled

7 more indications

Adult ALL1 trial

ALL Adult Consortium Trial: Adult ALL Trial

Completed·—·Phase 2·NCT00476190·112 enrolled

Induction Chemotherapy1 trial

Everolimus With Multiagent Re-Induction Chemotherapy in Pediatric Patients With ALL

Completed·—·Phase 1·NCT01523977·22 enrolled

Treatment1 trial

Poly(Ethylene Glycol)(PEG)-Asparaginase During Two Treatment Courses

Unknown status·NNordic Society for Pediatric Hematology and Oncology·Phase 4·NCT00192673·85 enrolled

Childhood Acute Lymphoblastic Leukemia1 trial

Vincristine, Dexamethasone, Doxorubicin, and PEG-asparaginase (VPLD) and Metformin for Relapsed Childhood Acute Lymphoblastic Leukemia (ALL)

Completed·HH. Lee Moffitt Cancer Center and Research Institute·Phase 1·NCT01324180·14 enrolled

Acute Lymphoid Leukemia1 trial

Adult Acute Lymphoblastic Leukemia Treated With Pediatric Regimen in Brazil - a Prospective Collaborative Study

Recruiting·IInstituto do Cancer do Estado de São Paulo··NCT05959720·180 enrolled

Leukemia1 trial

A Novel "Pediatric-Inspired" Regimen With Reduced Myelosuppressive Drugs for Adults (Aged 18-60) With Newly Diagnosed Ph Negative Acute Lymphoblastic Leukemia

Active, not recruiting·MMemorial Sloan Kettering Cancer Center·Phase 2·NCT01920737·39 enrolled

Leukemia, Acute Lymphoblastic1 trial

Phase 3 Trial to Investigate the Efficacy, Safety, and Tolerability of Blinatumomab as Consolidation Therapy Versus Conventional Consolidation Chemotherapy in Pediatric Subjects With HR First Relapse B-precursor ALL

Completed·Amgen·Phase 3·NCT02393859·111 enrolled

Details

Drug Info

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