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Oncovin

(Vincristine Sulfate)

Phase 3Small molecule

Vincristine sulfate is a chemotherapy drug used to treat various types of cancer, including leukemia and lymphoma, by stopping cancer cells from dividing and growing.[1] Oncovin is currently being investigated across 32 indications[3], with its most advanced program in Phase 3.[1]

Oncovin is one of 329 small molecule programs targeting Acute Lymphoblastic Leukemia. It is currently in Phase 3.

32

Indications

443

Total Trials

13

Active Trials

328

Competitors

2

FDA Applications

NDA/BLA/ANDA regulatory filings

Pipeline

Status by Indication[3][1]

Indication

Acute Lymphoblastic LeukemiaActive, not recruiting

LymphomaCompleted

RhabdomyosarcomaActive, not recruiting

Newly DiagnosedTerminated

T-Cell Non-Hodgkin LymphomaActive, not recruiting

T Acute Lymphoblastic LeukemiaCompleted

CIC-Rearranged SarcomaActive, not recruiting

B Acute Lymphoblastic LeukemiaActive, not recruiting

Ann Arbor Stage IIB Hodgkin LymphomaActive, not recruiting

Stage II Diffuse Large B-Cell LymphomaActive, not recruiting

Acute Lymphoblastic LeukemiaPhase 3

Active, not recruiting

LymphomaPhase 3

Completed

RhabdomyosarcomaPhase 3

Active, not recruiting

Newly DiagnosedPhase 3

Terminated

T-Cell Non-Hodgkin LymphomaPreclinical

Active, not recruiting

T Acute Lymphoblastic LeukemiaPhase 3

Completed

CIC-Rearranged SarcomaPreclinical

Active, not recruiting

B Acute Lymphoblastic LeukemiaPhase 3

Active, not recruiting

Ann Arbor Stage IIB Hodgkin LymphomaPhase 3

Active, not recruiting

Stage II Diffuse Large B-Cell LymphomaPhase 2

Active, not recruiting

Showing 10 of 32 indications

Competition

Competitive Landscape

401 competitors in Lymphoma

#DrugCompanyPhaseTrials

Oncovin

Zofran

Cabenuva

Norvir

Emend

CCidara Therapeutics Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)

Kenalog

BBausch Health Americas, Inc.

Systemic Therapy

Bristol-Myers Squibb

Elitek

AAzienda U.S.L. 1 di Massa e Carrara

Decadron

QQuince Therapeutics S.p.A.

Solu-Medrol

MMassachusetts Eye and Ear Infirmary

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q4 2026

Phase 2Recruiting

Acute Lymphoblastic Leukemia

NCT02877303

Q2 2027

Phase 2Active, not recruiting

Mantle Cell Lymphoma

NCT02427620

Q1 2028

Phase 3Active, not recruiting

Acute Lymphoblastic Leukemia

NCT01190930

Q2 2028

Phase 3Active, not recruiting

Medulloblastoma

NCT00392327

Clinical

Trials by Indication[1]

Lymphoma47 trials

Combination Chemotherapy Followed By Vaccine Therapy Plus Sargramostim in Treating Patients With Stage III or Stage IV Non-Hodgkin's Lymphoma

Unknown status·GGenitope Corporation·Phase 3·NCT00017290

Combination Chemotherapy, Rituximab, and Yttrium Y 90 Ibritumomab Tiuxetan in Treating Patients With Newly Diagnosed Large B-Cell Lymphoma

Completed·CCentre Antoine Lacassagne·Phase 2·NCT00690560·30 enrolled

Combination Chemotherapy in Treating Patients With Aggressive Non-Hodgkin's Lymphoma

Completed·LLymphoma Trials Office·Phase 3·NCT00005867·310 enrolled

Show 44 more trials

Combination Chemotherapy and Rituximab in Treating Patients With Newly Diagnosed AIDS-Related B-Cell Non-Hodgkin's Lymphoma

Completed·AAIDS Malignancy Consortium·Phase 2·NCT00389818·43 enrolled

Combination Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Patients With Newly Diagnosed Aggressive Non-Hodgkin's Lymphoma

Completed·SSwiss Cancer Institute·Phase 3·NCT00003215·400 enrolled

Alemtuzumab and Combination Chemotherapy in Treating Patients With Newly Diagnosed Stage II, Stage III, or Stage IV T-Cell Non-Hodgkin's Lymphoma

Unknown status·—·Phase 1/2·NCT00363090·84 enrolled

Alemtuzumab and Combination Chemotherapy in Treating Patients With Stage I, Stage II, Stage III, or Stage IV Peripheral T-Cell Lymphoma

Unknown status·CCancer Research UK·Phase 1·NCT00562068·30 enrolled

Combination Chemotherapy in Treating Older Patients With Non-Hodgkin's Lymphoma

Completed·EEuropean Organisation for Research and Treatment of Cancer - EORTC·Phase 2·NCT00039351·32 enrolled

Chemotherapy Plus Interferon Alfa Alone or With Radiation Therapy and Peripheral Stem Cell Transplantation in Treating Patients With Stage III or Stage IV Follicular Non-Hodgkin's Lymphoma

Terminated·EEuropean Organisation for Research and Treatment of Cancer - EORTC·Phase 3·NCT00003152·469 enrolled

Rituximab and Combination Chemotherapy With or Without Radiation Therapy in Treating Patients With B-Cell Non-Hodgkin's Lymphoma

Completed·UUnknown Sponsor·Phase 3·NCT00278408·700 enrolled

Liposomal Doxorubicin Plus Combination Chemotherapy in Treating Patients With AIDS-Associated Non-Hodgkin's Lymphoma

Completed·UUniversity of Alabama at Birmingham·Phase 1·NCT00004162·48 enrolled

Combination Chemotherapy With or Without Radiation Therapy and Peripheral Stem Cell Transplant in Treating Children With Hodgkin's Lymphoma

Unknown status·CChildren's Cancer and Leukaemia Group·Phase 2·NCT00025064·260 enrolled

Rituximab Followed by Combination Chemotherapy in Treating Patients With Refractory or Recurrent Non-Hodgkin's Lymphoma

Withdrawn·MMedstar Health Research Institute·Phase 2·NCT00006669

S9911, Combination Chemotherapy Plus Monoclonal Antibody Therapy in Treating Patients With Non-Hodgkin's Lymphoma

Completed·SSWOG Cancer Research Network·Phase 2·NCT00003784·102 enrolled

Comparison of Two Combination Chemotherapy Regimens in Treating Patients With Previously Untreated Aggressive Stage II, Stage III, or Stage IV Non-Hodgkin's Lymphoma

Completed·AAlliance for Clinical Trials in Oncology·Phase 2·NCT00005964·59 enrolled

Fludeoxyglucose F 18-PET/CT Imaging in Assessing Response to Chemotherapy in Patients With Newly Diagnosed Stage II, Stage III, or Stage IV Hodgkin Lymphoma

Completed·UUniversity College, London·Phase 3·NCT00678327·1,202 enrolled

Rituximab Plus Combination Chemotherapy in Treating Patients With HIV-Related Non-Hodgkin's Lymphoma

Unknown status·LLymphoma Trials Office·Phase 1·NCT00031902

A Study of Daratumumab and Dose-Adjusted EPOCH in Plasmablastic Lymphoma

Recruiting·AAIDS Malignancy Consortium·Phase 1·NCT04139304·15 enrolled

Radiation Therapy With or Without Combination Chemotherapy in Treating Patients With Previously Untreated Stage I or Stage II Hodgkin's Lymphoma

Active, not recruiting·EEuropean Organisation for Research and Treatment of Cancer - EORTC·Phase 3·NCT00379041·1,158 enrolled

Combination Chemotherapy and Rituximab in Treating Patients With Diffuse Large B-Cell Non-Hodgkin Lymphoma

Unknown status·CCancer Research UK·Phase 2·NCT00974792·150 enrolled

Combination Chemotherapy With or Without Etoposide in Treating Older Patients With Non-Hodgkin's Lymphoma

Terminated·EEuropean Organisation for Research and Treatment of Cancer - EORTC·Phase 2/3·NCT00060385·3 enrolled

Combination Chemotherapy Plus Interferon Alfa or Rituximab in Treating Patients With Stage III or Stage IV Lymphoma

Withdrawn·HHoag Memorial Hospital Presbyterian·Phase 2·NCT00004039

Combination Chemotherapy and Radiation Therapy in Treating Young Patients With Hodgkin's Lymphoma

Completed·CChristine Mauz-Körholz·Phase 2·NCT00416832·648 enrolled

Combination Chemotherapy in Treating Patients With Previously Untreated Advanced Hodgkin's Lymphoma

Unknown status·MMount Vernon Cancer Centre at Mount Vernon Hospital·Phase 3·NCT00041210·850 enrolled

Bortezomib, Combination Chemotherapy, and Rituximab as First-Line Therapy in Treating Patients With Stage III or Stage IV Follicular Non-Hodgkin's Lymphoma

Completed·NNCIC Clinical Trials Group·Phase 2·NCT00428142·95 enrolled

Combination Chemotherapy & Lenalidomide in Newly Diagnosed Stage II-IV Peripheral T-cell Non-Hodgkin's Lymphoma

Completed·UUniversity of Nebraska·Phase 1/2·NCT02561273·54 enrolled

SWOG-9704 Chemoradiotherapy and Peripheral Stem Cell Transplantation Compared With Combination Chemotherapy in Treating Patients With Non-Hodgkin's Lymphoma

Completed·SSWOG Cancer Research Network·Phase 3·NCT00004031·397 enrolled

Vaccine Therapy Plus Sargramostim Following Chemotherapy in Previously Untreated Aggressive Non-Hodgkin's Lymphoma

Completed·UUniversity of Nebraska·Phase 2·NCT00004197

Chemotherapy and Azidothymidine, With or Without Radiotherapy, for High Grade Lymphoma in AIDS-Risk Group Members

Completed·NNational Institute of Allergy and Infectious Diseases (NIAID)·N/A·NCT00000703·45 enrolled

Combination Chemotherapy With or Without Monoclonal Antibody Therapy in Treating Patients With Stage III or Stage IV Low-Grade Non-Hodgkin's Lymphoma

Completed·NNational Cancer Institute (NCI)·Phase 3·NCT00003204·515 enrolled

Biological Therapy After Chemotherapy in Treating Patients With Relapsed or Refractory Non-Hodgkin's Lymphoma

Completed·FFred Hutchinson Cancer Center·Phase 1·NCT00012207·12 enrolled

Fludeoxyglucose F 18 Positron Emission Tomography in Predicting Risk of Relapse in Patients With Non-Hodgkin's Lymphoma Who Are Undergoing Combination Chemotherapy With or Without Autologous Stem Cell or Bone Marrow Transplant

Completed·SSidney Kimmel Comprehensive Cancer Center at Johns Hopkins·Phase 2·NCT00238368·59 enrolled

Phase I Trial of mBACOD and Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) in AIDS-Associated Large Cell, Immunoblastic, and Small Non-cleaved Lymphoma

Completed·NNational Institute of Allergy and Infectious Diseases (NIAID)·Phase 1·NCT00000689·18 enrolled

Three Different Therapy Regimens in Treating Patients With Previously Untreated Hodgkin Lymphoma

Terminated·FFrench Innovative Leukemia Organisation·Phase 3·NCT00920153·442 enrolled

Combination Chemotherapy in Treating Patients With Intermediate-Grade or Immunoblastic Non-Hodgkin's Lymphoma

Completed·MM.D. Anderson Cancer Center·Phase 3·NCT00002565·61 enrolled

Combination Chemotherapy Followed by Donor Stem Cell Transplant in Treating Patients With Relapsed or High-Risk Primary Refractory Hodgkin Lymphoma

Completed·MMemorial Sloan Kettering Cancer Center·Phase 2·NCT00574496·25 enrolled

Combination Chemotherapy in Treating Patients With AIDS-Related Lymphoma

Completed·EEastern Cooperative Oncology Group·Phase 2·NCT00003388·38 enrolled

Rituximab and Combination Chemotherapy in Treating Patients With Newly Diagnosed, HIV-Associated Burkitt's Lymphoma

Completed·AAIDS Malignancy Consortium·Phase 2·NCT00392834·34 enrolled

Combination Chemotherapy and Monoclonal Antibody Therapy in Treating Patients With Non-Hodgkin's Lymphoma

Completed·AAlliance for Clinical Trials in Oncology·Phase 2·NCT00032019·78 enrolled

Combination Chemotherapy With or Without Monoclonal Antibody Therapy in Treating Patients With Previously Untreated HIV-Associated Non-Hodgkin's Lymphoma

Completed·NNational Cancer Institute (NCI)·Phase 3·NCT00003595·120 enrolled

Combination Chemotherapy in Treating Young Patients With Hodgkin's Lymphoma

Completed·CChristine Mauz-Körholz·Phase 3·NCT00433459·2,134 enrolled

Rituximab, Combination Chemotherapy, and Yttrium Y 90 Ibritumomab Tiuxetan in Treating Patients With Relapsed Follicular Non-Hodgkin Lymphoma

Terminated·UUniversity of Southampton·Phase 2·NCT00637832·1 enrolled

SWOG-9320 Combination Chemotherapy, Radiation Therapy, and Antiviral Therapy in Treating Patients With AIDS-Related Lymphoma

Completed·SSWOG Cancer Research Network·Phase 2·NCT00002571·52 enrolled

Combination Chemotherapy in Treating Patients With Advanced Hodgkin's Lymphoma

Completed·SStanford University·Phase 2·NCT00002715·50 enrolled

Combination Chemotherapy Followed By Radiation Therapy in Treating Patients With Aggressive Non-Hodgkin's Lymphoma

Completed·UUnknown Sponsor·Phase 3·NCT00053768·392 enrolled

S0349 Rituximab, Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone With or Without Oblimersen in Treating Patients With Advanced Diffuse Large B-Cell Non-Hodgkin's Lymphoma

Terminated·NNational Cancer Institute (NCI)·Phase 2·NCT00080847·160 enrolled

Diffuse Large B Cell Non-Hodgkin's Lymphoma in the Vulnerable/Frail Elderly. A Multicentric Randomized Phase II Trial

Completed·IInstitut Bergonié·Phase 2·NCT00911183·67 enrolled

Acute Lymphoblastic Leukemia39 trials

Low-Intensity Chemotherapy and Blinatumomab in Treating Patients With Philadelphia Chromosome Negative Relapsed or Refractory Acute Lymphoblastic Leukemia

Terminated·MM.D. Anderson Cancer Center·Phase 2·NCT03518112·6 enrolled

Combination Chemotherapy in Treating Children With Acute Lymphoblastic Leukemia

Completed·CChildren's Oncology Group·Phase 3·NCT00005603·276 enrolled

Venetoclax and a Pediatric-Inspired Regimen for the Treatment of Newly Diagnosed B Cell Acute Lymphoblastic Leukemia

Recruiting·—·Phase 1·NCT05157971·24 enrolled

Show 36 more trials

Blinatumomab, Inotuzumab Ozogamicin, and Combination Chemotherapy as Frontline Therapy in Treating Patients With B Acute Lymphoblastic Leukemia

Recruiting·MM.D. Anderson Cancer Center·Phase 2·NCT02877303·80 enrolled

Hormone Therapy Plus Chemotherapy in Treating Children With Acute Lymphoblastic Leukemia

Unknown status·MMedical Research Council·Phase 3·NCT00003437·1,800 enrolled

Combination Chemotherapy and Imatinib Mesylate in Treating Children With Relapsed Acute Lymphoblastic Leukemia

Completed·NNational Cancer Institute (NCI)·N/A·NCT00049569·126 enrolled

Asparaginase Erwinia Chrysanthemi With Chemotherapy for the Treatment of High-Risk Adults With Newly Diagnosed Acute Lymphoblastic Leukemia or Lymphoblastic Lymphoma

Recruiting·—·Phase 2·NCT06918431·53 enrolled

Temsirolimus, Dexamethasone, Mitoxantrone Hydrochloride, Vincristine Sulfate, and Pegaspargase in Treating Young Patients With Relapsed Acute Lymphoblastic Leukemia or Non-Hodgkin Lymphoma

Completed·NNational Cancer Institute (NCI)·Phase 1·NCT01403415·13 enrolled

Alemtuzumab and Combination Chemotherapy in Treating Patients With Untreated Acute Lymphoblastic Leukemia

Completed·NNational Cancer Institute (NCI)·Phase 1/2·NCT00061945·302 enrolled

Chemotherapy With or Without Bone Marrow Transplantation in Treating Patients With Acute Lymphoblastic Leukemia

Completed·EEuropean Organisation for Research and Treatment of Cancer - EORTC·Phase 3·NCT00002700·392 enrolled

Combination Chemotherapy in Treating Patients With Untreated Acute Lymphoblastic Leukemia

Completed·AAlliance for Clinical Trials in Oncology·Phase 2·NCT00003700·163 enrolled

Combination Chemotherapy in Treating Children With Acute Lymphoblastic Leukemia

Completed·CChildren's Oncology Group·Phase 3·NCT00005585·838 enrolled

Studying Body Mass Index in Younger Patients Who Are Receiving Treatment for High-Risk Acute Lymphoblastic Leukemia

Withdrawn·CChildren's Oncology Group··NCT00900445

Bortezomib and Combination Chemotherapy in Treating Patients With Relapsed or Refractory Acute Lymphoblastic Leukemia

Completed·SStanford University·Phase 2·NCT01769209·18 enrolled

Combination Chemotherapy With or Without Peripheral Stem Cell Transplant in Treating Children With Acute Lymphoblastic Leukemia

Completed·NNational Cancer Institute (NCI)·Phase 3·NCT00022737·220 enrolled

Bortezomib and Combination Chemotherapy in Treating Young Patients With Relapsed Acute Lymphoblastic Leukemia or Lymphoblastic Lymphoma

Completed·NNational Cancer Institute (NCI)·Phase 2·NCT00873093·148 enrolled

Radiation Therapy to the Head or Intrathecal Chemotherapy Plus High Dose Cytarabine in Preventing CNS Disease in Children With Acute Lymphoblastic Leukemia

Withdrawn·NNational Institutes of Health Clinical Center (CC)·Phase 3·NCT00019409

Imatinib Mesylate and Combination Chemotherapy With or Without a Donor Stem Cell Transplant in Treating Patients With Newly Diagnosed Acute Lymphoblastic Leukemia

Completed·—·Phase 2·NCT00618501·50 enrolled

Combination Chemotherapy and Ofatumumab in Treating Patients With Acute Lymphoblastic Leukemia or Lymphoblastic Lymphoma

Completed·MM.D. Anderson Cancer Center·Phase 2·NCT01363128·72 enrolled

Pre-reinductive Decitabine and Vorinostat in Relapsed Lymphoblastic Lymphoma or Acute Lymphoblastic Leukemia

Terminated·MMasonic Cancer Center, University of Minnesota·Phase 2·NCT00882206·15 enrolled

Phase III Study of Vincristine Sulfate Liposome For Injection In Adults With Naïve Acute Lymphoblastic Leukemia

Unknown status·UUnknown Sponsor·Phase 3·NCT02072785·480 enrolled

Combination Chemotherapy in Treating Young Patients With Newly Diagnosed Acute Lymphoblastic Leukemia

Unknown status·AAlliance for Clinical Trials in Oncology·Phase 2·NCT00558519·318 enrolled

Comparison of Different Combination Chemotherapy Regimens in Treating Infants With Acute Lymphoblastic Leukemia

Completed·DDutch Childhood Oncology Group·Phase 3·NCT00015873·350 enrolled

Personalized Kinase Inhibitor Therapy Combined With Chemotherapy in Treating Patients With Newly Diagnosed Acute Myeloid Leukemia and Acute Lymphoblastic Leukemia

Completed·OOHSU Knight Cancer Institute·Phase 1·NCT02779283·7 enrolled

Chemotherapy, Imatinib Mesylate, and Peripheral Stem Cell Transplantation in Treating Patients With Newly Diagnosed Acute Lymphoblastic Leukemia

Completed·NNational Cancer Institute (NCI)·Phase 2·NCT00039377·58 enrolled

Azacitidine and Combination Chemotherapy in Treating Infants With Acute Lymphoblastic Leukemia and KMT2A Gene Rearrangement

Completed·NNational Cancer Institute (NCI)·Phase 2·NCT02828358·78 enrolled

Combination Chemotherapy in Treating Children With Newly Diagnosed Acute Lymphoblastic Leukemia

Completed·CChildren's Oncology Group·Phase 3·NCT00005596·1,076 enrolled

Risk-Adjusted Combination Chemotherapy in Treating Young Patients With Acute Lymphoblastic Leukemia

Unknown status·—·Phase 3·NCT00764907·4,000 enrolled

Chemoimmunotherapy With Epratuzumab in Relapsed Acute Lymphoblastic Leukemia (ALL)

Completed·CChildren's Oncology Group·Phase 1/2·NCT00098839·134 enrolled

Combination Chemotherapy in Treating Children With Newly Diagnosed Acute Lymphoblastic Leukemia

Completed·CChildren's Oncology Group·Phase 3·NCT00002744·1,970 enrolled

Pegaspargase and Combination Chemotherapy in Treating Younger Patients With Newly Diagnosed High-Risk Acute Lymphoblastic Leukemia (Closed to Accrual 4-22-2011)

Completed·CChildren's Oncology Group·Phase 1·NCT00866307·104 enrolled

Etoposide, Prednisone, Vincristine Sulfate, Cyclophosphamide, and Doxorubicin in Treating Patients With Acute Lymphoblastic Leukemia or Lymphoblastic Lymphoma

Completed·UUniversity of Washington·Phase 2·NCT03023046·54 enrolled

Dasatinib and Combination Chemotherapy in Treating Young Patients With Newly Diagnosed Acute Lymphoblastic Leukemia

Completed·NNational Cancer Institute (NCI)·Phase 2/3·NCT00720109·63 enrolled

Risk-Adapted Chemotherapy in Treating Younger Patients With Newly Diagnosed Standard-Risk Acute Lymphoblastic Leukemia or Localized B-Lineage Lymphoblastic Lymphoma

Active, not recruiting·CChildren's Oncology Group·Phase 3·NCT01190930·9,350 enrolled

Calaspargase Pegol or Pegaspargase and Combination Chemotherapy in Treating Younger Patients With Newly Diagnosed High-Risk Acute Lymphoblastic Leukemia

Completed·CChildren's Oncology Group·Phase 3·NCT00671034·166 enrolled

International Collaborative Treatment Protocol For Children And Adolescents With Acute Lymphoblastic Leukemia

Completed·UUniversity Hospital Schleswig-Holstein·Phase 3·NCT01117441·6,136 enrolled

Induction Intensification in Treating Infants With Newly Diagnosed Acute Lymphoblastic Leukemia

Completed·CChildren's Oncology Group·Phase 2·NCT00002756·221 enrolled

Stem Cell Transplantation Compared With Standard Chemotherapy in Treating Patients With Acute Lymphoblastic Leukemia in First Remission

Completed·EEastern Cooperative Oncology Group·Phase 3·NCT00002514·1,929 enrolled

Combination Chemotherapy With or Without Donor Bone Marrow Transplantation in Treating Infants With Previously Untreated Acute Lymphoblastic Leukemia

Completed·CChildren's Oncology Group·Phase 2·NCT00022126·6 enrolled

Neuroblastoma8 trials

Combination Chemotherapy in Treating Infants With Newly Diagnosed Neuroblastoma Who Are Undergoing Surgery With or Without Autologous Bone Marrow or Peripheral Stem Cell Transplant

Unknown status·CChildren's Cancer and Leukaemia Group·Phase 3·NCT00417053

Combination Chemotherapy Plus Peripheral Stem Cell Transplantation Followed by Surgery and/or Radiation Therapy in Treating Young Patients With Advanced Neuroblastoma

Completed·CChildren's Oncology Group·Phase 1·NCT00002740·30 enrolled

Multiple Therapies in Treating Patients With Advanced Neuroblastoma

Completed·MMemorial Sloan Kettering Cancer Center·Phase 2·NCT00040872

Show 5 more trials

Combination Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Children With Newly Diagnosed Neuroblastoma

Completed·CChildren's Oncology Group·Phase 2·NCT00017368·42 enrolled

Combination Chemotherapy in Treating Infants With Newly Diagnosed Neuroblastoma

Completed·EEuropean Infant Neuroblastoma Study Group - 1999·Phase 2·NCT00025610

Combination Chemotherapy and Peripheral Stem Cell Transplantation in Treating Patients With Neuroblastoma

Completed·CChildren's Oncology Group·Phase 3·NCT00004188·495 enrolled

Combination Chemotherapy Followed By Surgery With or Without Radiation Therapy in Treating Young Patients With Stage II or Stage III Neuroblastoma

Unknown status·CChildren's Cancer and Leukaemia Group·Phase 3·NCT00276731

Combination Chemotherapy or Observation Following Surgery in Treating Infants With Neuroblastoma

Completed·—·Phase 2·NCT00002803·44 enrolled

Mantle Cell Lymphoma6 trials

S0601 Rituximab, Combination Chemotherapy, and Bortezomib Followed by Bortezomib Alone in Treating Patients With Newly Diagnosed Mantle Cell Lymphoma

Completed·SSWOG Cancer Research Network·Phase 2·NCT00376961·68 enrolled

Combination Chemotherapy, Bone Marrow or Peripheral Stem Cell Transplantation, and/or Biological Therapy in Treating Patients With Stage III or Stage IV Mantle Cell Lymphoma

Completed·NNorthwestern University·Phase 2·NCT00004231

Chemotherapy and Rituximab With Peripheral Stem Cell Transplantation in Treating Patients With Mantle Cell Lymphoma

Completed·AAlliance for Clinical Trials in Oncology·Phase 2·NCT00020943·79 enrolled

Show 3 more trials

S1106 Rituximab With Combination Chemotherapy or Bendamustine Hydrochloride Followed by Consolidation Chemotherapy and Stem Cell Transplantation in Older Patients With Previously Untreated Mantle Cell Lymphoma

Completed·SSWOG Cancer Research Network·Phase 2·NCT01412879·53 enrolled

Ibrutinib, Rituximab, and Consolidation Chemotherapy in Treating Young Patients With Newly Diagnosed Mantle Cell Lymphoma

Active, not recruiting·MM.D. Anderson Cancer Center·Phase 2·NCT02427620·131 enrolled

Combination Chemotherapy in Treating Patients With Newly Diagnosed Mantle Cell Lymphoma

Completed·MM.D. Anderson Cancer Center·Phase 2·NCT00003311·19 enrolled

Diffuse Large B-Cell Lymphoma6 trials

Oblimersen, Rituximab, Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone in Treating Patients With Stage II, Stage III, or Stage IV Diffuse Large B-Cell Lymphoma

Completed·BBritish Columbia Cancer Agency·Phase 1·NCT00070083

S1001 PET-Directed Therapy in Treating Patients With Limited-Stage Diffuse Large B-Cell Lymphoma

Completed·SSWOG Cancer Research Network·Phase 2·NCT01359592·159 enrolled

PET Scans in Patients With Diffuse Large B-Cell Lymphoma Receiving Rituximab, Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone

Completed·SSwiss Cancer Institute·N/A·NCT00544219·156 enrolled

Show 3 more trials

Combination Chemotherapy and Rituximab in Treating Patients With Primary Mediastinal Diffuse Large B-Cell Lymphoma

Unknown status·UUniversity Hospital Southampton NHS Foundation Trust·N/A·NCT00689845·120 enrolled

Everolimus, Rituximab, and Combination Chemotherapy in Treating Patients With Newly Diagnosed Untreated Diffuse Large B-Cell Lymphoma

Completed·AAlliance for Clinical Trials in Oncology·Phase 1·NCT01334502·26 enrolled

Monoclonal Antibody Therapy and Combination Chemotherapy in Treating Patients With Stage II, Stage III, or Stage IV Diffuse Large B-Cell Lymphoma

Completed·AAlliance for Clinical Trials in Oncology·Phase 2·NCT00301821·107 enrolled

50 more indications

Primitive Neuroectodermal Tumor6 trials

Surgery Plus Radiation Therapy With or Without Chemotherapy in Treating Children With Primitive Neuroectodermal Tumors of the CNS

Completed·SSociete Internationale d'Oncologie Pediatrique·Phase 3·NCT00003859·230 enrolled

Radiation Therapy Followed By Combination Chemotherapy in Treating Young Patients With Supratentorial Primitive Neuroectodermal Tumors

Unknown status·CChildren's Cancer and Leukaemia Group·Phase 2·NCT00274911·30 enrolled

Combination Chemotherapy Followed by Second-Look Surgery and Radiation Therapy in Treating Children With Nonmetastatic Medulloblastoma or Primitive Neuroectodermal Tumor

Completed·CChildren's Oncology Group·Phase 3·NCT00006461·82 enrolled

Show 3 more trials

Combination Chemotherapy Followed By Peripheral Stem Cell Transplant in Treating Young Patients With Newly Diagnosed Supratentorial Primitive Neuroectodermal Tumors or High-Risk Medulloblastoma

Completed·CChildren's Oncology Group·Phase 3·NCT00336024·91 enrolled

Combination Chemotherapy in Treating Patients With Newly Diagnosed Metastatic Ewing's Sarcoma or Primitive Neuroectodermal Tumor

Completed·NNational Cancer Institute (NCI)·Phase 2·NCT00002643·130 enrolled

Chemotherapy, Radiation Therapy, and Peripheral Stem Cell Transplantation in Treating Children With Newly Diagnosed Medulloblastoma or Supratentorial Primitive Neuroectodermal Tumor

Completed·SSt. Jude Children's Research Hospital·Phase 2·NCT00003211·94 enrolled

Multiple Myeloma6 trials

Chemotherapy, Stem Cell Transplantation and Donor and Patient Vaccination for Treatment of Multiple Myeloma

Completed·NNational Cancer Institute (NCI)·Phase 2·NCT00006184·20 enrolled

Combination Chemotherapy in Treating Patients With Stage II or Stage III Multiple Myeloma

Completed·WWest of Scotland Lymphoma Group·Phase 3·NCT00006232·200 enrolled

Combination Chemotherapy Following GM-CSF in Treating Patients With Multiple Myeloma

Completed·TThe Cleveland Clinic·Phase 2·NCT00003490·30 enrolled

Show 3 more trials

Combination Chemotherapy With or Without Thalidomide in Treating Patients With Multiple Myeloma

Unknown status·CCommissie Voor Klinisch Toegepast Onderzoek·Phase 3·NCT00028886·450 enrolled

Combination Chemotherapy and Thalidomide in Treating Patients With Stage I, Stage II, or Stage III Multiple Myeloma

Completed·RRoswell Park Cancer Institute·Phase 2·NCT00054158·24 enrolled

Combination Chemotherapy With or Without High Dose Cyclophosphamide and Recombinant Interferon Alfa-2b in Treating Patients With Previously Untreated Stage I-III Multiple Myeloma

Completed·NNational Cancer Institute (NCI)·Phase 3·NCT00002556·312 enrolled

Leukemia5 trials

Combination Chemotherapy in Treating Patients With Burkitt's Lymphoma or Burkitt's Leukemia

Completed·MMedical Research Council·Phase 2·NCT00040690·120 enrolled

Combination Chemotherapy in Treating Patients With Acute B-Lymphoblastic Leukemia or Non-Hodgkin's Lymphoma

Completed·MMemorial Sloan Kettering Cancer Center·Phase 2·NCT00002471

Combination Chemotherapy in Treating Adults With Acute Lymphocytic Leukemia

Unknown status·JJohann Wolfgang Goethe University Hospital·Phase 2·NCT00002531

Show 2 more trials

Comparison of Two Combination Chemotherapy Regimens in Treating Adults With Previously Untreated Leukemia or Lymphoma

Completed·MMemorial Sloan Kettering Cancer Center·Phase 3·NCT00002766·170 enrolled

Combination Chemotherapy in Treating Patients With Non-Hodgkin's Lymphoma or Acute Lymphocytic Leukemia

Completed·AAlliance for Clinical Trials in Oncology·Phase 2·NCT00002494·134 enrolled

Hodgkin's Disease5 trials

Combination Chemotherapy Plus Radiation Therapy in Treating Patients With Early-Stage Hodgkin's Disease

Completed·SStanford University·Phase 2·NCT00002714

RT or No RT Following Chemotherapy in Treating Patients With Stage III/IV Hodgkin's Disease

Active, not recruiting·EEuropean Organisation for Research and Treatment of Cancer - EORTC·Phase 3·NCT00002462·615 enrolled

Combination Chemotherapy in Treating Patients With Advanced Hodgkin's Disease

Completed·MMedical Research Council·Phase 3·NCT00003421·800 enrolled

Show 2 more trials

Combination Chemotherapy Given With Radiation Therapy or Radiation Therapy Alone in Treating Patients With Early-Stage Hodgkin's Disease

Unknown status·MMedical Research Council·Phase 3·NCT00002987·400 enrolled

Chemotherapy Followed by Radiation Therapy in Treating Young Patients With Newly Diagnosed Hodgkin's Disease

Completed·CChildren's Oncology Group·Phase 3·NCT00002827·294 enrolled

Retinoblastoma5 trials

Chemotherapy in Treating Patients With Retinoblastoma

Completed·MMemorial Sloan Kettering Cancer Center·Phase 2·NCT00002675·50 enrolled

Combination Chemotherapy, Autologous Stem Cell Transplant, and/or Radiation Therapy in Treating Young Patients With Extraocular Retinoblastoma

Completed·CChildren's Oncology Group·Phase 3·NCT00554788·60 enrolled

Neoadjuvant Carboplatin and Vincristine and Standard Local Ophthalmic Therapy in Treating Patients With Intraocular Retinoblastoma

Completed·CChildren's Oncology Group·Phase 3·NCT00079417·28 enrolled

Show 2 more trials

Chemotherapy With or Without Radiation Therapy or Observation in Treating Young Patients With Advanced Retinoblastoma Who Have Undergone Surgery to Remove the Eye

Unknown status·CChildren's Cancer and Leukaemia Group·N/A·NCT00360750

Carboplatin Plus Vincristine in Treating Children With Retinoblastoma

Completed·SSt. Jude Children's Research Hospital·Phase 2·NCT00002794·25 enrolled

Rhabdomyosarcoma4 trials

Vincristine, Dactinomycin, and Cyclophosphamide With or Without Radiation Therapy in Treating Patients With Newly Diagnosed Low-Risk Rhabdomyosarcoma

Completed·CChildren's Oncology Group·Phase 3·NCT00075582·390 enrolled

Combination Chemotherapy in Treating Children With Metastatic Rhabdomyosarcoma or Other Malignant Mesenchymal Tumors

Completed·SSociete Internationale d'Oncologie Pediatrique·Phase 2·NCT00025441

High-Dose Combination Chemotherapy and Radiation Therapy in Treating Patients With Newly Diagnosed Metastatic Rhabdomyosarcoma or Ectomesenchymoma

Completed·CChildren's Oncology Group·Phase 3·NCT00354744·109 enrolled

Show 1 more trial

Combination Chemotherapy in Treating Young Patients With Nonmetastatic Rhabdomyosarcoma

Unknown status·EEuropean Paediatric Soft Tissue Sarcoma Study Group·Phase 3·NCT00379457·600 enrolled

Medulloblastoma4 trials

Comparison of Radiation Therapy Regimens in Combination With Chemotherapy in Treating Young Patients With Newly Diagnosed Standard-Risk Medulloblastoma

Completed·CChildren's Oncology Group·Phase 3·NCT00085735·549 enrolled

Radiation Therapy and Combination Chemotherapy in Treating Young Patients With Metastatic Medulloblastoma Who Have Undergone Surgery

Unknown status·CChildren's Cancer and Leukaemia Group·Phase 2·NCT00276666·29 enrolled

Chemotherapy and Radiation Therapy in Treating Young Patients With Newly Diagnosed, Previously Untreated, High-Risk Medulloblastoma/PNET

Active, not recruiting·CChildren's Oncology Group·Phase 3·NCT00392327·379 enrolled

Show 1 more trial

Intrathecal Radioimmunotherapy, Radiation Therapy, and Chemotherapy After Surgery in Treating Patients With Medulloblastoma

Completed·MMemorial Sloan Kettering Cancer Center·N/A·NCT00058370·6 enrolled

Ependymoma3 trials

Observing Young Patients With Ependymoma Undergoing Standard Combination Chemotherapy

Active, not recruiting·CChildren's Cancer and Leukaemia Group··NCT00683319·50 enrolled

Combination Chemotherapy Followed by Radiation Therapy in Treating Children With Localized Ependymoma

Completed·SSociete Internationale d'Oncologie Pediatrique·Phase 2·NCT00004224·65 enrolled

Observation or Radiation Therapy and/or Chemotherapy and Second Surgery in Treating Children Who Have Undergone Surgery for Ependymoma

Completed·CChildren's Oncology Group·Phase 2·NCT00027846·378 enrolled

Small Cell Lung Cancer3 trials

Radiation Therapy Plus Combination Chemotherapy In Treating Patients With Limited Stage Small Cell Lung Cancer

Completed·LLondon Lung Cancer Group·Phase 3·NCT00003364·398 enrolled

Combination Chemotherapy Followed by Radiation Therapy in Patients With Small Cell Lung Cancer

Completed·MMedical Research Council·Phase 3·NCT00002822·400 enrolled

VX-710, Doxorubicin, and Vincristine for the Treatment of Patients With Recurrent Small Cell Lung Cancer

Terminated· Vertex Pharmaceuticals logo

Vertex Pharmaceuticals·Phase 2·NCT00003847·36 enrolled

Radiation Therapy3 trials

Vincristine, Dactinomycin, and Doxorubicin With or Without Radiation Therapy or Observation Only in Treating Younger Patients Who Are Undergoing Surgery for Newly Diagnosed Stage I, Stage II, or Stage III Wilms' Tumor

Active, not recruiting·CChildren's Oncology Group·Phase 3·NCT00352534·808 enrolled

Combination Chemotherapy, Radiation Therapy, and/or Surgery in Treating Patients With High-Risk Kidney Tumors

Completed·CChildren's Oncology Group·Phase 2·NCT00335556·291 enrolled

Combination Chemotherapy With or Without Radiation Therapy in Treating Children With Brain Tumors

Unknown status·CChildren's Cancer and Leukaemia Group·Phase 2·NCT00281905·50 enrolled

Bone Marrow Transplantation3 trials

SWOG-9400 Combination Chemotherapy With or Without Bone Marrow Transplantation in Treating Patients With Previously Untreated Acute Lymphocytic Leukemia

Completed·SSWOG Cancer Research Network·Phase 2·NCT00002665·50 enrolled

Combination Chemotherapy Followed by Surgery and Peripheral Stem Cell or Bone Marrow Transplantation in Treating Infants With Newly Diagnosed Neuroblastoma

Completed·EEuropean Infant Neuroblastoma Study Group - 1999·Phase 2·NCT00025649

Chemotherapy, Radiation Therapy, Immunotherapy, and Bone Marrow Transplantation in Treating Patients With Neuroblastoma

Completed·MMemorial Sloan Kettering Cancer Center·Phase 2·NCT00002634·45 enrolled

Glioma3 trials

Combination Chemotherapy and Radiation Therapy With or Without Methotrexate in Treating Young Patients With Newly Diagnosed Gliomas

Unknown status·GGerman Society for Pediatric Oncology and Hematology GPOH gGmbH·Phase 3·NCT00278278·150 enrolled

Combination Chemotherapy Plus Radiation Therapy in Treating Patients With Newly Diagnosed Brain Stem Glioma

Completed·CChildren's Oncology Group·Phase 1·NCT00003625·7 enrolled

Carboplatin, Vincristine, and Temozolomide in Treating Children With Progressive and/or Symptomatic Low-Grade Glioma

Completed·CChildren's Oncology Group·N/A·NCT00077207·66 enrolled

Chronic Lymphocytic Leukemia2 trials

Chemotherapy in Treating Patients With Newly Diagnosed Chronic Lymphocytic Leukemia

Completed·LLeukemia Research Fund·Phase 3·NCT00004218

Bryostatin 1 in Treating Patients With Relapsed Non-Hodgkin's Lymphoma or Chronic Lymphocytic Leukemia

Completed·BBarbara Ann Karmanos Cancer Institute·Phase 2·NCT00002908

Kaposi's sarcoma2 trials

A Randomized Phase III Clinical Trial of Daunoxome Versus Combination Chemotherapy With Adriamycin/Bleomycin/Vincristine (ABV) in the Treatment of HIV-Associated Kaposi's Sarcoma.

Completed·NNexstar Pharmaceuticals·Phase 3·NCT00002093

A Study of Chemotherapy Plus ddI or ddC in the Treatment of AIDS-Related Kaposi's Sarcoma

Completed·NNational Institute of Allergy and Infectious Diseases (NIAID)·Phase 1·NCT00000954·72 enrolled

Liposomal Doxorubicin2 trials

Comparison of Liposomal Doxorubicin Used Alone or in Combination With Bleomycin Plus Vincristine in the Treatment of Kaposi's Sarcoma in Patients With AIDS

Completed·NNational Institute of Allergy and Infectious Diseases (NIAID)·Phase 2·NCT00001059·120 enrolled

Randomized, Comparative Trial of DOX-SL (Stealth Liposomal Doxorubicin Hydrochloride) Versus Bleomycin and Vincristine in the Treatment of AIDS-Related Kaposi's Sarcoma

Completed·SSequus Pharmaceuticals·Phase 3·NCT00002105·220 enrolled

Stem Cell Transplantation2 trials

Stem Cell Transplantation in Patients With High-Risk and Recurrent Pediatric Sarcomas

Completed·NNational Cancer Institute (NCI)·Phase 2·NCT00043979·60 enrolled

Chemotherapy Followed by Peripheral Stem Cell Transplantation in Treating Children With Newly Diagnosed Brain Tumor

Withdrawn·NNYU Langone Health·Phase 2·NCT00003273

Chemotherapy2 trials

Combination Chemotherapy in Treating Patients With Sarcoma

Completed·MMayo Clinic·Phase 1·NCT00662233·28 enrolled

Combination Chemotherapy in Treating Children With Progressive Brain Tumors

Completed·CChildren's Oncology Group·Phase 3·NCT00002944·428 enrolled

Anaplastic Large Cell Lymphoma2 trials

Comparison of Two Combination Chemotherapy Regimens With Either Vincristine or Vinblastine in Treating Patients With Advanced Anaplastic Large Cell Lymphoma

Completed·CChildren's Oncology Group·Phase 3·NCT00059839·129 enrolled

Crizotinib and Combination Chemotherapy in Treating Younger Patients With Relapsed or Refractory Solid Tumors or Anaplastic Large Cell Lymphoma

Completed·CChildren's Oncology Group·Phase 1·NCT01606878·46 enrolled

Germ Cell Tumor1 trial

Combination Chemotherapy in Treating Children With Non-testicular Malignant Germ Cell Tumors

Completed·MMemorial Sloan Kettering Cancer Center·Phase 2·NCT00002489

B-cell Malignancies1 trial

Bryostatin and Vincristine in B-Cell Malignancies

Completed·NNational Cancer Institute (NCI)·Phase 1·NCT00003166·18 enrolled

T-cell non-Hodgkin lymphoma1 trial

Combination Chemotherapy and Denileukin Diftitox in Treating Patients With Newly Diagnosed T-Cell Non-Hodgkin Lymphoma

Withdrawn·UUniversity of Miami·N/A·NCT00513188

Precursor B-Cell Acute Lymphoblastic Leukemia1 trial

Therapy for Pediatric Relapsed or Refractory Precursor B-Cell Acute Lymphoblastic Leukemia and Lymphoma

Completed·SSt. Jude Children's Research Hospital·Phase 2·NCT01700946·80 enrolled

Allogeneic Stem Cell Transplantation1 trial

T-Cell-Depleted Allogeneic Stem Cell Transplantation After Immunoablative Induction Chemotherapy and Reduced-Intensity Transplantation Conditioning in Treating Patients With Hematologic Malignancies

Completed·NNational Institutes of Health Clinical Center (CC)·Phase 1·NCT00080925·20 enrolled

Quality of Life1 trial

Evaluating Quality of Life in Patients With AIDS-Associated Kaposi Sarcoma Treated With Bleomycin and Vincristine

Completed·AAIDS Malignancy Consortium··NCT03596918·10 enrolled

Anaplastic Oligodendroglioma1 trial

Radiation Therapy With or Without Chemotherapy in Treating Patients With Anaplastic Oligodendroglioma

Completed· Radiation Therapy Oncology Group logo

Radiation Therapy Oncology Group·Phase 3·NCT00002569·299 enrolled

Colon Cancer1 trial

Fluorouracil, Semustine, and Vincristine Compared With BCG in Treating Patients With Dukes' B or Dukes' C Colon Cancer That Has Been Removed By Surgery

Completed·NNSABP Foundation Inc·Phase 3·NCT00427570

Induction Therapy1 trial

Cladribine and Rituximab as Remission Induction Therapy Followed By Rituximab and Stem Cell Mobilization in Treating Patients With CLL

Completed·SSwiss Cancer Institute·Phase 2·NCT00072007·43 enrolled

Immunosuppression1 trial

SWOG-9239 Reduction of Immunosuppression Plus Interferon Alfa and Combination Chemotherapy in Treating Patients With Malignant Tumors That Develop After Organ Transplant

Completed·SSWOG Cancer Research Network·Phase 2·NCT00002657·20 enrolled

Malignant Pleural Mesothelioma1 trial

Active Symptom Control With or Without Chemotherapy in Treating Patients With Malignant Pleural Mesothelioma

Completed·MMedical Research Council·Phase 3·NCT00075699·840 enrolled

Acute Leukemia1 trial

Different Therapies in Treating Infants With Newly Diagnosed Acute Leukemia

Unknown status·DDutch Childhood Oncology Group·N/A·NCT00550992·445 enrolled

Low Grade Glioma1 trial

Carboplatin Plus Vincristine in Treating Children and Adolescents With Low Grade Glioma

Unknown status·SSociete Internationale d'Oncologie Pediatrique·Phase 3·NCT00003015·200 enrolled

B-cell acute lymphoblastic leukemia1 trial

Low-Dose or High-Dose Vincristine and Combination Chemotherapy in Treating Young Patients With Relapsed B-Cell Acute Lymphoblastic Leukemia

Completed·CChildren's Oncology Group·Phase 3·NCT00381680·275 enrolled

Biological Therapy1 trial

Combination Chemotherapy and Biological Therapy in Treating Patients With High-Risk Ewing's Sarcoma

Completed·MMemorial Sloan Kettering Cancer Center·Phase 2·NCT00003667

Chronic Myelogenous Leukemia1 trial

STI571 Plus Combination Chemotherapy in Treating Patients With Chronic Myelogenous Leukemia or Acute Lymphocytic Leukemia

Completed·JJonsson Comprehensive Cancer Center·Phase 1/2·NCT00015860

Central Nervous System Lymphoma1 trial

Phase II Trial of Sequential Chemotherapy and Radiotherapy for AIDS-Related Primary Central Nervous System Lymphoma

Completed·NNational Institute of Allergy and Infectious Diseases (NIAID)·Phase 2·NCT00000801·33 enrolled

Adjuvant Chemotherapy1 trial

Carboplatin and Vincristine Plus Radiation Therapy Followed By Adjuvant Chemotherapy in Treating Young Patients With Newly Diagnosed CNS Embryonal Tumors

Completed·CChildren's Oncology Group·Phase 2·NCT00003203·168 enrolled

HIV infection1 trial

Combination Chemotherapy in Treating Patients With Hodgkin's Disease and HIV Infection

Unknown status·CCentro di Riferimento Oncologico - Aviano·Phase 2·NCT00003262·30 enrolled

Lymphoblastic Lymphoma1 trial

Prednisolone or Dexamethasone Combined With Chemotherapy in Treating Young Patients With Newly Diagnosed Lymphoblastic Lymphoma

Terminated·CChildren's Cancer and Leukaemia Group·Phase 3·NCT00275106·600 enrolled

Vomiting1 trial

Rolapitant Hydrochloride in Preventing Nausea/Vomiting in Patients With Sarcoma Receiving Chemotherapy

Terminated·MM.D. Anderson Cancer Center·Phase 2·NCT02732015·37 enrolled

Brain Cancer1 trial

Combination Chemotherapy Plus Radiation Therapy in Treating Adult Patients With Brain Cancer

Completed·EEastern Cooperative Oncology Group·Phase 2·NCT00003309·33 enrolled

Fibroma1 trial

Medical Treatment of "High-Risk" Neurofibromas

Completed·CCorewell Health West·Phase 2·NCT00846430·9 enrolled

Newly Diagnosed1 trial

A Phase 3 Study to Evaluate Marqibo® in the Treatment of Subjects ≥ 60 Years Old With Newly Diagnosed ALL

Terminated· Spectrum Pharmaceuticals, Inc logo

Spectrum Pharmaceuticals, Inc·Phase 3·NCT01439347·26 enrolled

Soft Tissue Sarcoma1 trial

Combination Chemotherapy, Surgery, and Radiation Therapy in Treating Children With Advanced Soft Tissue Sarcoma

Completed·CChildren's Oncology Group·Phase 2·NCT00002804·43 enrolled

Ewing's Sarcoma1 trial

Vinblastine, Celecoxib, and Combination Chemotherapy in Treating Patients With Newly-Diagnosed Metastatic Ewing's Sarcoma Family of Tumors

Completed·CChildren's Oncology Group·Phase 2·NCT00061893·38 enrolled

Wilms tumor1 trial

Combination Chemotherapy and Surgery in Treating Young Patients With Wilms Tumor

Active, not recruiting·CChildren's Oncology Group·Phase 3·NCT00945009·249 enrolled

Ewing sarcoma1 trial

Two Regimens of Combination Chemotherapy in Treating Younger Patients With Newly Diagnosed Localized Ewing Sarcoma Family of Tumors

Completed·CChildren's Oncology Group·N/A·NCT00618813·35 enrolled

Safety and Efficacy1 trial

Multicenter Study of Safety and Efficacy Nivolumab at the Fixed Dose 40 mg (Nivo40) in Combination With Chemo-Immunotherapy for the Treatment of Newly Diagnosed PMBL

Recruiting·NNational Research Center for Hematology, Russia·Phase 3·NCT06188676·100 enrolled

Myeloma1 trial

SWOG-9321 Melphalan, TBI, and Transplant vs Combo Chemo in Untreated Myeloma

Completed·SSWOG Cancer Research Network·Phase 3·NCT00002548·899 enrolled

Malignant Brain Tumors1 trial

Combination Chemotherapy With or Without Etoposide Followed By an Autologous Stem Cell Transplant in Treating Young Patients With Previously Untreated Malignant Brain Tumors

Unknown status·—·Phase 3·NCT00392886·120 enrolled

Lenalidomide1 trial

Smart Start: A Phase II Study of Rituximab, Lenalidomide, and Ibrutinib

Completed·MM.D. Anderson Cancer Center·Phase 2·NCT02636322·60 enrolled

Regulatory

FDA Approval Timeline[4]

Jan 1, 1982

ONCOVIN

NDA NDA014103

Aug 9, 2012

MARQIBO KIT

NDA NDA202497

Sources

References

[1]
ClinicalTrials.gov — 443 trial records for Vincristine Sulfate. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — Vincristine Sulfate compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for Vincristine Sulfate. EMBL-EBI & Wellcome Sanger Institute.
[4]
OpenFDA — FDA approval records (NDA NDA202497). U.S. Food & Drug Administration.
[5]
SEC EDGAR — Eli Lilly company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Mechanism of Action: Tubulin Inhibitor[2]
Modality: Small molecule[2]
Highest Phase: Phase 3[1]
Company: Eli Lilly

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