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Wellcovorin

(Leucovorin Calcium)

Phase 3Small molecule

EEastern Cooperative Oncology Group

Leucovorin Calcium is used to reduce the harmful side effects of certain cancer drugs like methotrexate, and to boost the effectiveness of cancer treatments like 5-fluorouracil. It's also used to treat a type of anemia caused by folate deficiency.[1] Wellcovorin is currently being investigated across 35 indications[3], with its most advanced program in Phase 3.[1]

Wellcovorin is one of 430 small molecule programs targeting Colorectal Cancer. It is currently in Phase 3.

35

Indications

414

Total Trials

9

Active Trials

429

Competitors

Pipeline

Status by Indication[3][1]

Indication

Colorectal CancerCompleted

Acute Lymphoblastic LeukemiaActive, not recruiting

T-Cell Non-Hodgkin LymphomaActive, not recruiting

ImmunodeficiencyActive, not recruiting

Appendix CancerNot yet recruiting

B Acute Lymphoblastic LeukemiaActive, not recruiting

Advanced Biliary Tract CarcinomaActive, not recruiting

Metastatic Pancreatic AdenocarcinomaActive, not recruiting

Clinical Stage IV Gastric Cancer AJCC V8Active, not recruiting

Rectal AdenocarcinomaRecruiting

Colorectal CancerPhase 3

Completed

Acute Lymphoblastic LeukemiaPhase 3

Active, not recruiting

T-Cell Non-Hodgkin LymphomaPreclinical

Active, not recruiting

ImmunodeficiencyPreclinical

Active, not recruiting

Appendix CancerPhase 3

Not yet recruiting

B Acute Lymphoblastic LeukemiaPhase 3

Active, not recruiting

Advanced Biliary Tract CarcinomaPhase 2

Active, not recruiting

Metastatic Pancreatic AdenocarcinomaPhase 2

Active, not recruiting

Clinical Stage IV Gastric Cancer AJCC V8Phase 1

Active, not recruiting

Rectal AdenocarcinomaPhase 2

Recruiting

Showing 10 of 35 indications

Competition

Competitive Landscape

335 competitors in Pancreatic Cancer

#DrugCompanyPhaseTrials

Wellcovorin

EEastern Cooperative Oncology Group

Medrol

Byetta

Ayvakit Sprinkle

MMemorial Sloan Kettering Cancer Center

Xylocaine

MMEDRx USA, Inc.

Feraheme

AAzurity Pharmaceuticals

MS Contin

HHikma Pharmaceuticals LLC

Active Comparator

Sulfonylureas

Hyperpolarized 13c Pyruvate

UUniversity of Maryland, Baltimore

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q4 2026

Phase 3Active, not recruiting

Acute Lymphoblastic Leukemia

NCT02883049

Phase 2Active, not recruiting

Stage III Rectal Cancer

NCT00335816

Q1 2027

Phase 2Active, not recruiting

Pancreatic Cancer

NCT04539808

Phase 1/2Recruiting

Pancreatic Adenocarcinoma

NCT05688215

Q3 2029

Phase 3Recruiting

Pancreatic Cancer

NCT04927780

Q4 2030

Post-ApprovalRecruiting

Congenital Toxoplasmosis

NCT00004317

Clinical

Trials by Indication[1]

Metastatic Colorectal Cancer35 trials

Radiolabeled Monoclonal Antibody Therapy, Combination Chemotherapy, and Bevacizumab in Treating Patients With Metastatic Colorectal Cancer

Completed·—·Phase 1·NCT01205022·3 enrolled

Combination Chemotherapy and Bevacizumab in Treating Patients With Metastatic Colorectal Cancer

Completed·FFederation Francophone de Cancerologie Digestive·Phase 2·NCT00628810·86 enrolled

Combination Chemotherapy and Bevacizumab as First-Line Therapy in Treating Patients With Metastatic Colorectal Cancer

Completed·GGruppo Oncologico del Nord-Ovest·Phase 3·NCT00719797·509 enrolled

Show 32 more trials

Bevacizumab and Combination Chemotherapy as First-Line Therapy in Treating Patients With Metastatic Colorectal Cancer That Cannot Be Removed by Surgery

Completed·IInstitut Bergonié·Phase 2·NCT00467142·62 enrolled

Irinotecan, Fluorouracil, Leucovorin, and Oxaliplatin as First-Line Therapy in Treating Patients With Metastatic Colorectal Cancer

Completed·AAlliance for Clinical Trials in Oncology·Phase 2·NCT00080951·14 enrolled

Combination Chemotherapy and Cetuximab or Bevacizumab in Treating Patients With Metastatic Colorectal Cancer

Terminated·FFox Chase Cancer Center·N/A·NCT01280643·3 enrolled

Combination Chemotherapy and Bevacizumab With or Without RO4929097 in Treating Patients With Metastatic Colorectal Cancer

Withdrawn·NNational Cancer Institute (NCI)·Phase 2·NCT01270438

MRI in Predicting Response in Patients Receiving Combination Chemotherapy and Bevacizumab For Advanced or Metastatic Colorectal Cancer

Terminated·—·Phase 2·NCT00602329·5 enrolled

Sorafenib Tosylate, Bevacizumab, Irinotecan Hydrochloride, Leucovorin Calcium, and Fluorouracil in Treating Patients With Metastatic Colorectal Cancer

Completed·NNational Cancer Institute (NCI)·Phase 1·NCT01383343·17 enrolled

Liposome-encapsulated Irinotecan Hydrochloride PEP02 or Irinotecan Hydrochloride, Leucovorin Calcium, and Fluorouracil as Second-Line Therapy in Treating Patients With Metastatic Colorectal Cancer

Terminated·GGERCOR - Multidisciplinary Oncology Cooperative Group·Phase 2·NCT01375816·55 enrolled

Bevacizumab and Combination Chemotherapy in Treating Patients With Previously Untreated Metastatic Colorectal Cancer That Cannot Be Removed By Surgery

Unknown status·SSouthern Italy Cooperative Oncology Group·Phase 3·NCT00797485·672 enrolled

Combination Chemotherapy and Cetuximab as First-Line Therapy in Treating Patients With Advanced and/or Metastatic Colorectal Cancer

Completed·CCheryl Pugh·Phase 2·NCT00640081·169 enrolled

MEK Inhibitor MEK162 in Combination With Leucovorin Calcium, Fluorouracil, and Oxaliplatin in Treating Patients With Advanced Metastatic Colorectal Cancer

Completed·—·Phase 1·NCT02041481·26 enrolled

Bevacizumab and Combination Chemotherapy as First-Line Therapy in Treating Patients With Metastatic Colorectal Cancer That Cannot Be Removed By Surgery

Completed·UUNICANCER·Phase 2·NCT00423696·145 enrolled

Erlotinib and Combination Chemotherapy in Treating Patients With Metastatic Colorectal Cancer

Completed·MMemorial Sloan Kettering Cancer Center·Phase 1/2·NCT00049101

Fluorouracil-Uracil and Leucovorin in Treating Elderly Patients With Metastatic Colorectal Cancer

Completed·EEastern Cooperative Oncology Group·Phase 2·NCT00004860

Vitamin D3 With Chemotherapy and Bevacizumab in Treating Patients With Advanced or Metastatic Colorectal Cancer

Active, not recruiting·AAlliance for Clinical Trials in Oncology·Phase 3·NCT04094688·455 enrolled

Combination Chemotherapy and Bevacizumab With or Without Bevacizumab Maintenance Therapy in Treating Patients With Metastatic Colorectal Cancer

Completed·FFederation Francophone de Cancerologie Digestive·Phase 2/3·NCT00952029·492 enrolled

Combination Chemotherapy as First-Line Therapy in Treating Older Patients With Metastatic Colorectal Cancer That Cannot Be Removed By Surgery

Completed·FFederation Francophone de Cancerologie Digestive·Phase 3·NCT00303771·282 enrolled

Combination Chemotherapy in Treating Patients With Metastatic Colorectal Cancer

Unknown status·GGERCOR - Multidisciplinary Oncology Cooperative Group·Phase 2·NCT00006115

Leucovorin and Fluorouracil With or Without Oxaliplatin Compared to Capecitabine With or Without Oxaliplatin in Treating Patients With Metastatic Colorectal Cancer

Completed·MMedical Research Council·Phase 3·NCT00070213·460 enrolled

Combination Chemotherapy With or Without Cetuximab as First-Line Therapy in Treating Patients With Metastatic Colorectal Cancer

Unknown status·VVelindre NHS Trust·Phase 3·NCT00182715·2,421 enrolled

Riluzole in Combination With mFOLFOX6 and Bevacizumab in Treating Patients With Metastatic Colorectal Cancer

Completed·NNing Jin·Phase 1·NCT04761614·13 enrolled

Combination Chemotherapy in Treating Patients With Metastatic Colorectal Cancer That Cannot Be Removed By Surgery

Unknown status·GGERCOR - Multidisciplinary Oncology Cooperative Group·Phase 2/3·NCT00274872·600 enrolled

Combination Chemotherapy With or Without SU5416 in Treating Patients With Metastatic Colorectal Cancer

Unknown status·JJonsson Comprehensive Cancer Center·Phase 3·NCT00021281

Comparing Two Combination Chemotherapy Regimens in Treating Patients With Metastatic Colorectal Cancer

Unknown status·GGERCOR - Multidisciplinary Oncology Cooperative Group·Phase 3·NCT00006468

Combination Chemotherapy and Radiation Therapy in Treating Patients With Recurrent Metastatic Colorectal Cancer

Completed·GGERCOR - Multidisciplinary Oncology Cooperative Group·Phase 2·NCT00268333·39 enrolled

5-FU Based Maintenance Therapy in RAS Wild Type Metastatic Colorectal Cancer After Induction With FOLFOX Plus Panitumumab

Terminated·UUniversity of Southern California·Phase 3·NCT03300609·4 enrolled

Short-Infusion Ziv-aflibercept in Treating Patients With Metastatic Colorectal Cancer Receiving Combination Chemotherapy

Withdrawn·—·N/A·NCT01941173

Combination Chemotherapy and Bevacizumab Before Surgery and Radiolabeled Monoclonal Antibody Therapy in Treating Liver Metastases in Patients With Metastatic Colorectal Cancer

Terminated·—·Phase 2·NCT01320683·1 enrolled

Combination Chemotherapy in Treating Patients With Recurrent or Metastatic Colorectal Cancer

Unknown status·SStony Brook University·Phase 1/2·NCT00003001·63 enrolled

G-CSF in Preventing Neutropenia During First-Line Treatment With Chemotherapy and Bevacizumab in Patients With Metastatic Colorectal Cancer

Completed·FFederation Francophone de Cancerologie Digestive·Phase 2·NCT00541125·20 enrolled

Combination Chemotherapy With or Without Celecoxib in Treating Patients With Metastatic Colorectal Cancer

Completed·EEuropean Organisation for Research and Treatment of Cancer - EORTC·Phase 3·NCT00064181·86 enrolled

Combination Chemotherapy in Treating Patients With Metastatic Colorectal Cancer Previously Treated With Irinotecan

Completed·NNational Cancer Institute (NCI)·Phase 2·NCT00016978·40 enrolled

Combination Chemotherapy Plus Bevacizumab With or Without Oxaliplatin in Treating Older Patients With Metastatic Colorectal Cancer

Terminated·AAlliance for Clinical Trials in Oncology·Phase 3·NCT01279681·32 enrolled

Colorectal Cancer33 trials

Gefitinib and Combination Chemotherapy in Treating Patients With Advanced or Recurrent Colorectal Cancer

Terminated·NNational Cancer Institute (NCI)·Phase 2·NCT00052585·50 enrolled

Suberoylanilide Hydroxamic Acid, Fluorouracil, Leucovorin, and Oxaliplatin in Treating Patients With Progressive Metastatic or Unresectable Colorectal Cancer or Other Solid Tumors

Completed·NNational Cancer Institute (NCI)·Phase 1·NCT00138177·54 enrolled

A Phase I, Pharmacological, and Biological Study of OSI-774 in Combination With FOLFOX 4 (5-FU, Leucovorin, and Oxaliplatin) and Bevacizumab (Avastin) in Patients With Advanced Colorectal Cancer

Completed·NNational Cancer Institute (NCI)·Phase 1·NCT00060411·24 enrolled

Show 30 more trials

Irinotecan Hydrochloride With FOLFIRI and Cetuximab as First-Line Therapy in Treating Patients With RAS Wild-Type Colorectal Cancer

Withdrawn·UUniversity of Chicago·Phase 1·NCT02573220

Chemotherapy and Internal Radiation in Treating Patients With Colorectal Cancer That Has Spread to the Liver

Unknown status·—·Phase 2·NCT00408551·20 enrolled

Intravenous Compared With Intrahepatic Chemotherapy in Treating Patients With Colorectal Cancer Metastatic to the Liver

Unknown status·MMedical Research Council·Phase 3·NCT00002692·312 enrolled

Combination Chemotherapy in Treating Patients With Liver Metastases From Colorectal Cancer

Completed·AAlliance for Clinical Trials in Oncology·Phase 2·NCT00003834·44 enrolled

Combination Chemotherapy Plus Bevacizumab in Treating Patients With Advanced Colorectal Cancer

Completed·EEastern Cooperative Oncology Group·Phase 2·NCT00006786

Combination Chemotherapy and Monoclonal Antibody Therapy in Treating Patients With Advanced Colorectal Cancer With Liver Metastases or Lung Metastases That Are Potentially Removable by Surgery

Unknown status·—·Phase 2·NCT00513266·35 enrolled

Chemotherapy With or Without Isolated Hepatic Perfusion With Melphalan in Treating Patients With Colorectal Cancer That Has Spread to the Liver

Completed·NNational Institutes of Health Clinical Center (CC)·Phase 3·NCT00020501

Panobinostat and Fluorouracil Followed By Leucovorin Calcium in Treating Patients With Stage IV Colorectal Cancer Who Did Not Respond to Previous Fluorouracil-Based Chemotherapy

Terminated·UUniversity of Southern California·Phase 1·NCT01238965·7 enrolled

Isolated Hepatic Perfusion With Melphalan Followed by Combination Chemotherapy in Treating Patients With Unresectable Liver Metastases From Colorectal Cancer

Completed·NNational Cancer Institute (NCI)·Phase 2·NCT00103298

Isolated Hepatic Perfusion With Melphalan Followed By Chemotherapy in Treating Patients With Unresectable Colorectal Cancer That is Metastatic to the Liver

Completed·NNational Institutes of Health Clinical Center (CC)·Phase 2·NCT00019760

Surgery With or Without Combination Chemotherapy in Treating Patients With Liver Metastases From Colorectal Cancer

Unknown status·EEuropean Organisation for Research and Treatment of Cancer - EORTC·Phase 3·NCT00006479

Chemotherapy and Cetuximab in Patients Undergoing Surgery for Peritoneal Carcinomatosis From Colorectal Cancer

Terminated·IInstitut Bergonié·Phase 2·NCT00766142·18 enrolled

Biological Therapy With Combination Chemotherapy in Patients With Colorectal Cancer

Unknown status·EEuropean Institute of Oncology·Phase 3·NCT00003063·1,050 enrolled

Arsenic Trioxide, Fluorouracil, and Leucovorin in Treating Patients With Stage IV Colorectal Cancer That Has Relapsed or Not Responded to Treatment

Completed·UUniversity of Miami·Phase 1·NCT00449137·13 enrolled

Cetuximab and Bevacizumab as First-Line Therapy Followed By Combination Chemotherapy and Bevacizumab With or Without Cetuximab as Second-Line Therapy in Treating Patients With Stage IV Colorectal Cancer

Withdrawn·AAlliance for Clinical Trials in Oncology·Phase 2·NCT00571740

Second-look Surgery With or Without Intraperitoneal Chemotherapy in Treating Patients With Recurrent Colorectal Cancer

Terminated·UUNICANCER·Phase 2·NCT00005944

Gefitinib and Combination Chemotherapy in Treating Patients With Advanced Solid Tumors or Colorectal Cancer

Completed·SStanford University·Phase 2·NCT00025142

Adjuvant Hepatic Arterial Infusion and Combination Chemotherapy in Treating Patients With Resectable Hepatic Metastases From Colorectal Cancer

Completed·MMemorial Sloan Kettering Cancer Center·Phase 1·NCT00059930·38 enrolled

Bevacizumab and Oxaliplatin Combined With Irinotecan or Leucovorin and Fluorouracil in Treating Patients With Metastatic or Recurrent Colorectal Cancer

Completed·EEastern Cooperative Oncology Group·Phase 2·NCT00098787·247 enrolled

Panitumumab and Chemotherapy in Patients With Advanced Colorectal Cancer After Prior Therapy With Bevacizumab

Completed·JJohn Hays·Phase 2·NCT01814501·16 enrolled

Combination Chemotherapy and Oblimersen in Treating Patients With Advanced Colorectal Cancer

Completed·TThe University of Texas Health Science Center at San Antonio·Phase 1/2·NCT00055822·16 enrolled

Systemic Chemotherapy With or Without Intraperitoneal Chemohyperthermia in Treating Patients Undergoing Surgery for Peritoneal Carcinomatosis From Colorectal Cancer

Completed·UUNICANCER·Phase 3·NCT00769405·264 enrolled

Leucovorin, Fluorouracil, Cetuximab, and Oxaliplatin in Treating Patients With Stage IV Colorectal Cancer and Liver Metastases That Cannot Be Removed by Surgery

Completed·GGustave Roussy, Cancer Campus, Grand Paris·Phase 2·NCT00544349·45 enrolled

Immediate Compared With Delayed Chemotherapy in Advanced Colorectal Cancer Without Signs or Symptoms of Disease

Completed·NNCIC Clinical Trials Group·Phase 3·NCT00002570·67 enrolled

Oxaliplatin and Bevacizumab (Avastin™) With Either Fluorouracil and Leucovorin or Capecitabine in Treating Patients With Advanced Colorectal Cancer

Completed·PPrologue Research International·Phase 3·NCT00062426

Combination Chemotherapy in Treating Patients With Liver Metastases From Colorectal Cancer

Completed·AAlliance for Clinical Trials in Oncology·Phase 3·NCT00002716·135 enrolled

Ursodiol, Combination Chemotherapy, and Bevacizumab in Treating Patients With Stage IV Colorectal Cancer

Completed·—·Phase 1·NCT00873275·11 enrolled

Study of Tumor Tissue Testing in Selecting Treatment for Patients With Metastatic or Locally Advanced Colorectal Cancer

Completed·MMedical Research Council·Phase 2/3·NCT00975897·3,240 enrolled

Combination Chemotherapy in Treating Patients With Colorectal Cancer That Has Spread to the Liver

Completed·UUNICANCER·Phase 2·NCT00006050

Chemotherapy and Bevacizumab With or Without Radiofrequency Ablation in Treating Unresectable Liver Metastases in Patients With Colorectal Cancer

Terminated·EEuropean Organisation for Research and Treatment of Cancer - EORTC·Phase 2·NCT00043004·119 enrolled

Acute Lymphoblastic Leukemia18 trials

Dasatinib Followed by Stem Cell Transplant in Treating Older Patients With Newly Diagnosed Acute Lymphoblastic Leukemia

Completed·NNational Cancer Institute (NCI)·Phase 2·NCT01256398·66 enrolled

Radiation Therapy and Chemotherapy in Treating Children With CNS Relapse From Acute Lymphoblastic Leukemia

Completed·NNational Cancer Institute (NCI)·Phase 2·NCT00002704·156 enrolled

Combination Chemotherapy in Treating Children With Relapsed Acute Lymphoblastic Leukemia

Completed·CChildren's Oncology Group·Phase 3·NCT00002816·120 enrolled

Show 15 more trials

Combination Chemotherapy With or Without Lestaurtinib in Treating Younger Patients With Newly Diagnosed Acute Lymphoblastic Leukemia

Completed·CChildren's Oncology Group·Phase 3·NCT00557193·218 enrolled

Combination Chemotherapy and Imatinib Mesylate in Treating Children With Relapsed Acute Lymphoblastic Leukemia

Completed·NNational Cancer Institute (NCI)·N/A·NCT00049569·126 enrolled

Dasatinib and Combination Chemotherapy in Treating Young Patients With Newly Diagnosed Acute Lymphoblastic Leukemia

Completed·NNational Cancer Institute (NCI)·Phase 2/3·NCT00720109·63 enrolled

Combination Chemotherapy in Treating Children With Newly Diagnosed Acute Lymphoblastic Leukemia

Completed·CChildren's Oncology Group·Phase 3·NCT00005596·1,076 enrolled

Combination Chemotherapy in Treating Patients With Acute Lymphoblastic Leukemia or Advanced Lymphoblastic Non-Hodgkin's Lymphoma

Completed·CChildren's Oncology Group·Phase 3·NCT01230983·573 enrolled

Low-Intensity Chemotherapy and Blinatumomab in Treating Patients With Philadelphia Chromosome Negative Relapsed or Refractory Acute Lymphoblastic Leukemia

Terminated·MM.D. Anderson Cancer Center·Phase 2·NCT03518112·6 enrolled

Combination Chemotherapy in Treating Children With Acute Lymphoblastic Leukemia, Osteosarcoma, or Non-Hodgkin's Lymphoma

Completed·MMemorial Sloan Kettering Cancer Center·Phase 2·NCT00002738·25 enrolled

Imatinib Mesylate and Combination Chemotherapy With or Without a Donor Stem Cell Transplant in Treating Patients With Newly Diagnosed Acute Lymphoblastic Leukemia

Completed·—·Phase 2·NCT00618501·50 enrolled

Stem Cell Transplantation Compared With Standard Chemotherapy in Treating Patients With Acute Lymphoblastic Leukemia in First Remission

Completed·EEastern Cooperative Oncology Group·Phase 3·NCT00002514·1,929 enrolled

Dexamethasone Compared With Prednisone During Induction Therapy and Methotrexate With or Without Leucovorin During Maintenance Therapy in Treating Patients With Newly Diagnosed High-Risk Acute Lymphoblastic Leukemia

Completed·CChildren's Oncology Group·Phase 3·NCT00075725·3,154 enrolled

Nilotinib and Combination Chemotherapy in Treating Patients With Newly Diagnosed Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia or Blastic Phase Chronic Myelogenous Leukemia

Withdrawn·MMayo Clinic·Phase 2·NCT01670084

Combination Chemotherapy in Treating Patients With Newly Diagnosed Acute Lymphoblastic Leukemia

Completed·NNational Cancer Institute (NCI)·N/A·NCT00016302·100 enrolled

Combination Chemotherapy and Radiation Therapy in Treating Patients With Acute Lymphoblastic Leukemia That Has Relapsed in the CNS or Testes

Completed·CChildren's Oncology Group·N/A·NCT00096135·168 enrolled

Induction Intensification in Treating Infants With Newly Diagnosed Acute Lymphoblastic Leukemia

Completed·CChildren's Oncology Group·Phase 2·NCT00002756·221 enrolled

Combination Chemotherapy in Treating Young Patients With Newly Diagnosed High-Risk B Acute Lymphoblastic Leukemia and Ph-Like TKI Sensitive Mutations

Active, not recruiting·NNational Cancer Institute (NCI)·Phase 3·NCT02883049·5,949 enrolled

Pancreatic Cancer9 trials

Stereotactic Radiation, Nelfinavir Mesylate & Neoadjuvant Chemotherapy in Locally Advanced Pancreatic Cancer

Completed·UUniversity of Nebraska·Phase 1·NCT01068327·46 enrolled

CPI-613 and Combination Chemotherapy in Treating Patients With Metastatic Pancreatic Cancer

Completed·WWake Forest University Health Sciences·Phase 1·NCT01835041·21 enrolled

Ascorbic Acid and Combination Chemotherapy in Treating Patients With Locally Advanced or Recurrent Pancreatic Cancer That Cannot Be Removed by Surgery

Completed·SSidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University·Phase 1·NCT02896907·8 enrolled

Show 6 more trials

BATS With in Combination With Low Dose IL-1 and GM-CSF for Advanced Pancreatic Cancer

Completed·BBarbara Ann Karmanos Cancer Institute·Phase 1/2·NCT02620865·2 enrolled

NeoOPTIMIZE: Early Switching of mFOLFIRINOX or Gemcitabine/Nab-Paclitaxel Before Surgery for the Treatment of Resectable, Borderline Resectable, or Locally-Advanced Unresectable Pancreatic Cancer

Active, not recruiting·OOHSU Knight Cancer Institute·Phase 2·NCT04539808·42 enrolled

Combination Chemotherapy With or Without Ganitumab in Treating Patients With Previously Untreated Metastatic Pancreatic Cancer

Withdrawn·AAlliance for Clinical Trials in Oncology·Phase 1/2·NCT01473303

Combination Chemotherapy, and Radiation Therapy in Treating Patients With Locally Advanced Pancreatic Cancer

Completed·UUniversity of Nebraska·Phase 2·NCT00089024·29 enrolled

Perioperative or Adjuvant mFOLFIRINOX for Resectable Pancreatic Cancer

Recruiting·EErasmus Medical Center·Phase 3·NCT04927780·378 enrolled

Combination Chemotherapy as First-Line Therapy in Treating Patients With Metastatic Pancreatic Cancer

Completed·UUNICANCER·Phase 2/3·NCT00112658·342 enrolled

Lymphoma9 trials

Rituximab and Combination Chemotherapy in Treating Patients With Newly Diagnosed Primary CNS Lymphoma

Completed·AAlliance for Clinical Trials in Oncology·Phase 2·NCT00098774·47 enrolled

Combination Chemotherapy in Treating Patients With Lymphoma

Completed·MM.D. Anderson Cancer Center·Phase 3·NCT00002835·116 enrolled

SWOG-9320 Combination Chemotherapy, Radiation Therapy, and Antiviral Therapy in Treating Patients With AIDS-Related Lymphoma

Completed·SSWOG Cancer Research Network·Phase 2·NCT00002571·52 enrolled

Show 6 more trials

Methotrexate and Thiotepa in Treating Patients With Newly Diagnosed Primary CNS Lymphoma

Completed·NNew Approaches to Brain Tumor Therapy Consortium·Phase 2·NCT00045539

Combination Chemotherapy in Treating Patients With Recurrent, Refractory, or Metastatic Solid Tumors or Lymphomas

Completed·NNational Institutes of Health Clinical Center (CC)·Phase 1·NCT00019513·108 enrolled

Combination Chemotherapy and Rituximab in Treating Patients With Newly Diagnosed Primary CNS Lymphoma

Completed·UUniversity of California, San Francisco·N/A·NCT00416819·10 enrolled

Chemotherapy and Azidothymidine, With or Without Radiotherapy, for High Grade Lymphoma in AIDS-Risk Group Members

Completed·NNational Institute of Allergy and Infectious Diseases (NIAID)·N/A·NCT00000703·45 enrolled

Phase I Trial of mBACOD and Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) in AIDS-Associated Large Cell, Immunoblastic, and Small Non-cleaved Lymphoma

Completed·NNational Institute of Allergy and Infectious Diseases (NIAID)·Phase 1·NCT00000689·18 enrolled

Combination Chemotherapy in Treating Patients With AIDS-Related Lymphoma

Completed·MM.D. Anderson Cancer Center·Phase 2·NCT00002524·46 enrolled

55 more indications

Leukemia7 trials

Combination Chemotherapy in Treating Patients With Non-Hodgkin's Lymphoma or Acute Lymphocytic Leukemia

Completed·AAlliance for Clinical Trials in Oncology·Phase 2·NCT00002494·134 enrolled

Combination Chemotherapy in Treating Patients With Relapsed or Refractory Acute Lymphocytic Leukemia

Unknown status·HHannover Medical School·Phase 2·NCT00002532

Aminopterin in Treating Patients With Refractory Leukemia

Completed· Sanofi logo

Sanofi·Phase 2·NCT00003305·75 enrolled

Show 4 more trials

Combination Chemotherapy in Treating Patients With Burkitt's Lymphoma or Burkitt's Leukemia

Completed·MMedical Research Council·Phase 2·NCT00040690·120 enrolled

High-Intensity, Brief-Duration Chemotherapy in Treating Patients With Relapsed or Refractory Acute Lymphocytic Leukemia

Completed·WWake Forest University Health Sciences·Phase 2·NCT00002865·25 enrolled

Combination Chemotherapy in Treating Children With Very High Risk Acute Lymphocytic Leukemia

Completed·CChildren's Oncology Group·Phase 2·NCT00003783·36 enrolled

Rituximab, Rasburicase, and Combination Chemotherapy in Treating Young Patients With Newly Diagnosed Advanced B-Cell Leukemia or Lymphoma

Completed·CChildren's Oncology Group·Phase 2·NCT00057811·97 enrolled

Esophageal Cancer5 trials

PET Scan Imaging in Assessing Response in Patients With Esophageal Cancer Receiving Combination Chemotherapy

Completed·AAlliance for Clinical Trials in Oncology·Phase 2·NCT01333033·257 enrolled

Sunitinib, Irinotecan, Fluorouracil, and Leucovorin In Treating Patients With Advanced Stomach Cancer or Gastroesophageal Cancer

Terminated·RRoswell Park Cancer Institute·Phase 1·NCT00524186·23 enrolled

Chemotherapy and Radiation Therapy After Surgery in Treating Patients With Stomach or Esophageal Cancer

Completed·AAlliance for Clinical Trials in Oncology·Phase 3·NCT00052910·546 enrolled

Show 2 more trials

Everolimus and Combination Chemotherapy in Treating Patients With Metastatic Stomach or Esophageal Cancer

Completed·—·Phase 1/2·NCT01231399·6 enrolled

Molecular Phenotyping in Predicting Response in Patients With Stage IB-III Esophageal Cancer Receiving Combination Chemotherapy

Terminated·—·Phase 2·NCT02392377·1 enrolled

Radiation Therapy5 trials

Chemotherapy Combined With Radiation Therapy for Newly Diagnosed CNS AT/RT

Completed·—·Phase 2·NCT00084838·25 enrolled

Radiation Therapy, Chemotherapy, and Cetuximab Followed by Surgery, Chemotherapy, and Cetuximab in Treating Patients With Locally Advanced or Metastatic Rectal Cancer That Can Be Removed by Surgery

Terminated·UUNICANCER·Phase 2·NCT00541112·19 enrolled

Radiation Therapy and Chemotherapy Followed by Surgery and Combination Chemotherapy in Treating Patients With Rectal Cancer

Completed·FFox Chase Cancer Center·Phase 2·NCT00021398·23 enrolled

Show 2 more trials

Chemotherapy and Radiation Therapy in Treating Patients With Stomach Cancer

Completed· Radiation Therapy Oncology Group logo

Radiation Therapy Oncology Group·Phase 2·NCT00003862

Bevacizumab, Radiation Therapy, and Combination Chemotherapy in Treating Patients Who Are Undergoing Surgery for Locally Advanced Nonmetastatic Rectal Cancer

Completed·NNational Cancer Institute (NCI)·Phase 2·NCT00321685·57 enrolled

Pneumonia5 trials

A Treatment Protocol for the Use of Trimetrexate With Leucovorin Rescue for AIDS Patients With Pneumocystis Carinii Pneumonia and Serious Intolerance to Approved Therapies

Completed·NNational Institute of Allergy and Infectious Diseases (NIAID)·Phase 3·NCT00001016

Randomized Phase I Study of Trimetrexate Glucuronate (TMTX) With Leucovorin (LCV) Protection Plus Dapsone Versus Trimethoprim / Sulfamethoxazole (TMP/SMX) for Treatment of Moderately Severe Episodes of Pneumocystis Carinii Pneumonia

Completed·UU.S. Bioscience·Phase 1·NCT00002120·20 enrolled

A Study of Trimetrexate With Leucovorin Rescue for AIDS Patients Who Are Refractory to Standard Therapies for Pneumocystis Carinii Pneumonia

Completed·NNational Institute of Allergy and Infectious Diseases (NIAID)·Phase 3·NCT00000724

Show 2 more trials

A Study of Trimetrexate Plus Leucovorin in Children With Pneumocystis Carinii Pneumonia

Completed·UU.S. Bioscience·N/A·NCT00002317

Trimetrexate Plus Leucovorin Calcium Rescue Versus Sulfamethoxazole-Trimethoprim in the Treatment of Pneumocystis Carinii Pneumonia (PCP) in Patients With AIDS

Completed·NNational Institute of Allergy and Infectious Diseases (NIAID)·Phase 3·NCT00001014·302 enrolled

Osteosarcoma4 trials

Chemotherapy With or Without Trastuzumab in Treating Patients With Metastatic Osteosarcoma

Completed·NNational Cancer Institute (NCI)·Phase 2·NCT00023998·80 enrolled

Combination Chemotherapy and Surgery in Treating Patients With Newly Diagnosed Metastatic Osteosarcoma

Completed·MMemorial Sloan Kettering Cancer Center·Phase 2·NCT00003776

Zoledronic Acid and Combination Chemotherapy in Treating Patients With Newly Diagnosed Metastatic Osteosarcoma

Completed·CChildren's Oncology Group·Phase 1·NCT00742924·24 enrolled

Show 1 more trial

Combination Chemotherapy Before and After Surgery in Treating Patients With Osteosarcoma

Terminated·NNational Cancer Institute (NCI)·Phase 2·NCT00019864·100 enrolled

Stage III Colon Cancer4 trials

Vaccine Therapy in Treating Patients With Stage II or Stage III Colon Cancer That Has Been Removed During Surgery

Completed·IIntracel·Phase 1/2·NCT00016133

Fluorouracil, Leucovorin, and Oxaliplatin With or Without Bevacizumab in Treating Patients Who Have Undergone Surgery for Stage II or Stage III Colon Cancer

Completed·NNational Cancer Institute (NCI)·Phase 3·NCT00096278·2,710 enrolled

Combination Chemotherapy in Treating Patients With Stage III Colon Cancer

Completed·NNational Cancer Institute (NCI)·Phase 3·NCT00003835·1,260 enrolled

Show 1 more trial

Combination Chemotherapy With or Without Bevacizumab in Treating Patients Who Have Undergone Surgery for High Risk Stage II or Stage III Colon Cancer

Completed· Roche logo

Roche·Phase 3·NCT00112918·3,451 enrolled

Advanced Cancer3 trials

Combination Chemotherapy in Treating Patients With Advanced Cancer That is Metastatic or Cannot Be Removed By Surgery

Completed·NNational Cancer Institute (NCI)·Phase 1·NCT00043121·50 enrolled

Combination Chemotherapy In Treating Patients With Advanced Cancer

Completed·BBarbara Ann Karmanos Cancer Institute·Phase 1·NCT00003925·36 enrolled

Combination Chemotherapy in Treating Patients With Advanced Cancer

Completed·NNational Cancer Institute (NCI)·Phase 1·NCT00021073·90 enrolled

Patients With Advanced Solid Tumors3 trials

A Phase II Study of Envofolimab and BD0801 With/Without Chemotherapy in Patients With Advanced Solid Tumors

Terminated· Jiangsu Simcere Pharmaceutical Co., Ltd. logo

Jiangsu Simcere Pharmaceutical Co., Ltd.·Phase 2·NCT05148195·86 enrolled

Combination Chemotherapy in Treating Patients With Advanced Solid Tumors

Withdrawn·UUniversity of Pittsburgh·Phase 1·NCT00009815

Alvocidib, Oxaliplatin, Fluorouracil, and Leucovorin Calcium in Treating Patients With Advanced Solid Tumors

Completed·NNational Cancer Institute (NCI)·Phase 1·NCT00080990·46 enrolled

Colon Cancer3 trials

Circulating Tumor DNA Testing in Predicting Treatment for Patients With Stage IIA Colon Cancer After Surgery

Active, not recruiting·NNRG Oncology·Phase 2/3·NCT04068103·635 enrolled

Fluorouracil and Leucovorin and/or Levamisole After Surgery In Treating Patients With Dukes' B Or Dukes' C Colon Cancer

Completed·NNSABP Foundation Inc·Phase 3·NCT00425152·2,151 enrolled

Standard Therapy With or Without Surgery and Mitomycin C in Treating Patients With Advanced Limited Peritoneal Dissemination of Colon Cancer

Terminated·AAlliance for Clinical Trials in Oncology·Phase 3·NCT01167725·340 enrolled

Rectal Cancer2 trials

Phase I Study of Neoadjuvant Radiotherapy With 5-Fluorouracil for Rectal Cancer

Completed·VVirginia Commonwealth University·Phase 1·NCT02270606·14 enrolled

Postoperative Chemotherapy With or Without Bevacizumab for Patients With Stage II or III Rectal Cancer

Terminated·EECOG-ACRIN Cancer Research Group·Phase 3·NCT00303628·355 enrolled

Gallbladder Cancer2 trials

Combination Chemotherapy in Treating Patients With Unresectable or Metastatic Biliary Tract or Gallbladder Cancer

Completed·AAlliance for Clinical Trials in Oncology·Phase 2·NCT00009893·42 enrolled

Trametinib or Combination Chemotherapy in Treating Patients With Refractory or Advanced Biliary or Gallbladder Cancer or That Cannot Be Removed by Surgery

Completed·NNational Cancer Institute (NCI)·Phase 2·NCT02042443·53 enrolled

Adenocarcinoma2 trials

S0304 Induct Chemo Then Chemo-RT in Pts w/Locally Advanced Adenocarcinoma of the Rectum

Withdrawn·SSWOG Cancer Research Network·Phase 2·NCT00070434

Celecoxib Combined With Fluorouracil and Leucovorin in Treating Patients With Resected Stage III Adenocarcinoma (Cancer) of the Colon

Completed·EEuropean Organisation for Research and Treatment of Cancer - EORTC·Phase 3·NCT00085163

Cancer of the Pancreas2 trials

Combination Chemotherapy in Treating Patients With Advanced Cancer of the Pancreas

Completed·UUniversity of Southern California·Phase 2·NCT00002955·21 enrolled

Surgery Followed by Radiation Therapy and Chemotherapy in Treating Patients With Cancer of the Pancreas

Completed·MMayo Clinic·Phase 3·NCT00003049·100 enrolled

Germ Cell Tumor2 trials

Combination Chemotherapy in Treating Children With Non-testicular Malignant Germ Cell Tumors

Completed·MMemorial Sloan Kettering Cancer Center·Phase 2·NCT00002489

Alvocidib and Oxaliplatin With or Without Fluorouracil and Leucovorin Calcium in Treating Patients With Relapsed or Refractory Germ Cell Tumors

Completed·NNational Cancer Institute (NCI)·Phase 2·NCT00957905·36 enrolled

Cancer of the Esophagus2 trials

Oxaliplatin Combined With Fluorouracil and Leucovorin in Treating Patients With Recurrent or Metastatic Cancer of the Esophagus or Stomach

Completed·UUniversity of Chicago·Phase 2·NCT00004127·35 enrolled

S9915 Triacetyluridine, Fluorouracil, and Leucovorin in Treating Patients With Unresectable, Locally Advanced, or Metastatic Cancer of the Esophagus or Stomach

Completed·SSWOG Cancer Research Network·Phase 2·NCT00004233·65 enrolled

Patients With Solid Tumors2 trials

High-Dose Methotrexate in Treating Young Patients With Solid Tumors

Completed·CChildren's Cancer and Leukaemia Group·Phase 1·NCT00513981·36 enrolled

Bortezomib, Fluorouracil, and Leucovorin Calcium in Treating Patients With Solid Tumors That Are Metastatic or Cannot Be Removed By Surgery

Completed·NNational Cancer Institute (NCI)·Phase 1·NCT00007878·30 enrolled

Stomach Cancer2 trials

High-Dose Chemotherapy in Treating Patients With Advanced Stomach Cancer

Completed·EEuropean Organisation for Research and Treatment of Cancer - EORTC·Phase 2·NCT00002722·135 enrolled

Bortezomib, Fluorouracil, and Leucovorin in Treating Patients With Metastatic or Unresectable Stomach Cancer

Terminated·CCalifornia Cancer Consortium·Phase 2·NCT00103103

Stage III Rectal Cancer2 trials

Radiation Therapy and Fluorouracil With or Without Combination Chemotherapy Followed by Surgery in Treating Patients With Stage II or Stage III Rectal Cancer

Active, not recruiting·MMemorial Sloan Kettering Cancer Center·Phase 2·NCT00335816·248 enrolled

Radiation Therapy With or Without Chemotherapy Before Surgery in Treating Patients With Stage II or Stage III Rectal Cancer

Completed·FFederation Francophone de Cancerologie Digestive·Phase 3·NCT00296608·762 enrolled

Pancreatic Adenocarcinoma2 trials

Preoperative Folfirinox for Resectable Pancreatic Adenocarcinoma - A Phase II Study

Terminated·—·Phase 2·NCT02345460·1 enrolled

Zimberelimab and Quemliclustat in Combination With Chemotherapy for the Treatment of Patients With Borderline Resectable and Locally Advanced Pancreatic Adenocarcinoma

Recruiting·JJonsson Comprehensive Cancer Center·Phase 1/2·NCT05688215·56 enrolled

Gastroesophageal Junction Cancer2 trials

Combination Chemotherapy With or Without Vismodegib in Treating Patients With Advanced Stomach Cancer or Gastroesophageal Junction Cancer

Completed·NNational Cancer Institute (NCI)·Phase 2·NCT00982592·124 enrolled

S1201: Combination Chemo for Patients W/Advanced or Metastatic Esophageal, Gastric, or Gastroesophageal Junction Cancer

Completed·SSWOG Cancer Research Network·Phase 2·NCT01498289·213 enrolled

Locally Advanced Head and Neck Cancer1 trial

Chemotherapy Followed by Surgery, Chemotherapy, and Radiation Therapy in Treating Patients With Locally Advanced Head And Neck Cancer

Completed·—·Phase 2·NCT00544414·31 enrolled

Bevacizumab1 trial

CAPOXIRI+Bevacizumab vs. FOLFOXIRI+Bevacizumab for mCRC

Unknown status· Roche logo

Roche·Phase 2·NCT04097444·112 enrolled

Biliary Cancer1 trial

Cediranib Maleate and Combination Chemotherapy in Treating Patients With Advanced Biliary Cancers

Terminated·NNational Cancer Institute (NCI)·Phase 2·NCT01229111·14 enrolled

Biliary Tract Cancer1 trial

FOLFIRI as Salvage Treatment in Metastatic Biliary Tract Cancer (BTC) Patients Who Were Failed After Gemcitabine Containing Chemotherapy: A Phase II Single Arm Prospective Study

Withdrawn·SSamsung Medical Center·Phase 2·NCT03110510

Patients With Locally Advanced Rectal Cancer1 trial

Combination Chemotherapy and Bevacizumab With or Without Radiation Therapy in Treating Patients With Locally Advanced Rectal Cancer

Completed·MMemorial Sloan Kettering Cancer Center·N/A·NCT00462501·35 enrolled

Intraperitoneal Chemotherapy1 trial

Combination Chemotherapy Followed by Surgery and Intraperitoneal Chemotherapy in Treating Patients With Locally Advanced Stomach Cancer

Completed·MMemorial Sloan Kettering Cancer Center·Phase 2·NCT00006038

Cancer of the Stomach1 trial

Combination Chemotherapy in Treating Patients With Metastatic or Recurrent Cancer of the Stomach or Esophagus

Unknown status·—·Phase 2·NCT00005607

Cancer of Unknown Primary1 trial

Chemotherapy in Treating Patients With Cancer of Unknown Primary Origin

Unknown status·AAcademisch Ziekenhuis Maastricht·Phase 3·NCT00003558·140 enrolled

Central Nervous System Lymphoma1 trial

Methotrexate, Glucarpidase, and Leucovorin in Treating Patients With Newly Diagnosed Primary Central Nervous System Lymphoma

Completed·UUniversity College, London·Phase 1/2·NCT00727831·4 enrolled

Gastroesophageal Junction1 trial

Pembrolizumab, Combination Chemotherapy, and Radiation Therapy Before Surgery in Treating Adult Patients With Locally Advanced Gastroesophageal Junction or Gastric Cardia Cancer That Can Be Removed by Surgery

Completed·MMayo Clinic·Phase 1/2·NCT02730546·31 enrolled

Stem Cell Transplant1 trial

Donor Stem Cell Transplant After Busulfan, Fludarabine, and Antithymocyte Globulin in Treating Patients With Hematological Cancer

Completed·—·Phase 2·NCT00627666·52 enrolled

Prevention1 trial

Phase II Trial of Aprepitant & Palonosetron for CINV Prevention w FOLFOX

Completed·OOHSU Knight Cancer Institute·Phase 2·NCT00381862·54 enrolled

Primitive Neuroectodermal Tumor1 trial

Combination Chemotherapy Followed By Peripheral Stem Cell Transplant in Treating Young Patients With Newly Diagnosed Supratentorial Primitive Neuroectodermal Tumors or High-Risk Medulloblastoma

Completed·CChildren's Oncology Group·Phase 3·NCT00336024·91 enrolled

Chemotherapy1 trial

Combination Chemotherapy in Treating Patients With Colon Cancer

Unknown status·GGroupe Regional d'Etudes du Cancer Colorectal·Phase 3·NCT00046995·800 enrolled

Non-Small Cell Lung Cancer1 trial

AZD2171 and Standard Combination Chemotherapy in Advanced Non-Small Cell Lung Cancer or Colorectal Cancer

Completed·NNCIC Clinical Trials Group·Phase 1·NCT00343408·31 enrolled

Metastatic Neuroendocrine Tumor1 trial

Combination Chemotherapy as First-Line Therapy in Treating Patients With Locally Advanced or Metastatic Neuroendocrine Tumors of the Duodenum or Pancreas That Cannot Be Removed By Surgery

Completed·FFederation Francophone de Cancerologie Digestive·Phase 2·NCT00416767·20 enrolled

Azithromycin1 trial

A Study of Azithromycin Plus Pyrimethamine in the Treatment of a Brain Infection in Patients With AIDS

Completed· Pfizer logo

Pfizer·Phase 1·NCT00000966·45 enrolled

Unresectable Solid Tumor1 trial

UCN-01, Fluorouracil, and Leucovorin in Treating Patients With Metastatic or Unresectable Solid Tumors

Completed·NNational Cancer Institute (NCI)·Phase 1·NCT00042861

Breast Cancer1 trial

Combination Chemotherapy in Treating Older Women With Metastatic Breast Cancer

Unknown status·GGERCOR - Multidisciplinary Oncology Cooperative Group·Phase 2·NCT00010075

Anaplastic Large Cell Lymphoma1 trial

Combination Chemotherapy Followed By Stem Cell Transplant in Treating Young Patients With Progressive or Relapsed Anaplastic Large Cell Lymphoma

Unknown status·EEuropean Inter-group Cooperation on Childhood and Adolescent Non Hodgkin Lymphoma·N/A·NCT00317408·96 enrolled

Mycosis Fungoides1 trial

Combination Chemotherapy in Patients With Advanced or Recurrent Mycosis Fungoides

Unknown status·NNational Cancer Institute (NCI)·Phase 2·NCT00002557·3 enrolled

Congenital Toxoplasmosis1 trial

Pyrimethamine, Sulfadiazine, and Leucovorin in Treating Patients With Congenital Toxoplasmosis

Recruiting·NNational Institute of Allergy and Infectious Diseases (NIAID)·Phase 4·NCT00004317·600 enrolled

Gastrointestinal Tumors1 trial

Alisertib and Combination Chemotherapy in Treating Patients With Gastrointestinal Tumors

Completed·NNational Cancer Institute (NCI)·Phase 1·NCT02319018·14 enrolled

Immunodeficiency1 trial

A Randomized, Double-Blind, Placebo Controlled Study of l-Leucovorin in Combination With Trimethoprim / Sulfamethoxazole in the Therapy of Pneumocystis Carinii Pneumonia in Patients With the Acquired Immunodeficiency Syndrome

Completed·LLederle Laboratories·N/A·NCT00002002

Atypical Teratoid/Rhabdoid Tumor1 trial

Combination Chemotherapy, Radiation Therapy, and an Autologous Peripheral Blood Stem Cell Transplant in Treating Young Patients With Atypical Teratoid/Rhabdoid Tumor of the Central Nervous System

Completed·CChildren's Oncology Group·Phase 3·NCT00653068·70 enrolled

Metastatic Cancer1 trial

Oxaliplatin With Or Without Floxuridine and Leucovorin in Treating Patients With Metastatic Cancer of the Peritoneum

Completed·MMemorial Sloan Kettering Cancer Center·Phase 1·NCT00005860

Advanced Malignancies1 trial

Phase IB Study to Evaluate the Safety of Selinexor (KPT-330) in Combination With Multiple Standard Chemotherapy or Immunotherapy Agents in Patients With Advanced Malignancies

Terminated·MM.D. Anderson Cancer Center·Phase 1·NCT02419495·221 enrolled

Lymphoblastic Lymphoma1 trial

Prednisolone or Dexamethasone Combined With Chemotherapy in Treating Young Patients With Newly Diagnosed Lymphoblastic Lymphoma

Terminated·CChildren's Cancer and Leukaemia Group·Phase 3·NCT00275106·600 enrolled

Mantle Cell Lymphoma1 trial

Chemotherapy and Rituximab With Peripheral Stem Cell Transplantation in Treating Patients With Mantle Cell Lymphoma

Completed·AAlliance for Clinical Trials in Oncology·Phase 2·NCT00020943·79 enrolled

Gastrointestinal1 trial

Genotype-guided Dosing of mFOLFIRINOX Chemotherapy in Patients With Previously Untreated Advanced Gastrointestinal Malignancies

Completed·UUniversity of Chicago·Phase 1·NCT01643499·79 enrolled

Adjuvant Chemotherapy1 trial

Comparison of Adjuvant Chemotherapy Regimens in Treating Stage II/III Rectal Cancer

Completed·NNational Cancer Institute (NCI)·Phase 3·NCT00068692·225 enrolled

Locally Advanced or Metastatic Solid Tumors1 trial

Combination Chemotherapy in Treating Patients With Locally Advanced or Metastatic Solid Tumors

Completed·NNational Cancer Institute (NCI)·Phase 1·NCT00042874·77 enrolled

Locally Advanced1 trial

Bevacizumab and Combination Chemotherapy Before Surgery in Treating Patients With Locally Advanced Esophageal or Stomach Cancer

Completed·FFox Chase Cancer Center·Phase 2·NCT01212822·20 enrolled

Gastric Cancer1 trial

Chemotherapy, Surgery, and Radiation Therapy in Treating Patients With Gastric Cancer

Completed·EECOG-ACRIN Cancer Research Group·Phase 2·NCT00003298·39 enrolled

Gastroesophageal Junction Adenocarcinoma1 trial

Preoperative Hypofractionated Radiotherapy With FOLFOX for Esophageal or Gastroesophageal Junction Adenocarcinoma

Recruiting·MMayo Clinic·Phase 2·NCT06078709·99 enrolled

Sources

References

[1]
ClinicalTrials.gov — 414 trial records for Leucovorin Calcium. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — Leucovorin Calcium compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for Leucovorin Calcium. EMBL-EBI & Wellcome Sanger Institute.
[4]
SEC EDGAR — Eastern Cooperative Oncology Group company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[2]
Highest Phase: Phase 3[1]
Company: EEastern Cooperative Oncology Group

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