Wellcovorin
(Leucovorin Calcium)ApprovedSmall molecule
Leucovorin Calcium is used to reduce the harmful side effects of certain cancer drugs like methotrexate, and to boost the effectiveness of cancer treatments like 5-fluorouracil. It's also used to treat a type of anemia caused by folate deficiency.[2] Wellcovorin is currently approved and in use across 84 indications[4].[1]
Wellcovorin is one of 1189 small molecule programs targeting Glioma. It is currently in Approved.
84
Indications
412
Total Trials
16
Active Trials
1,188
Competitors
Pipeline
Status by Indication[4][1]
Indication
Showing 10 of 84 indications
Competition
Competitive Landscape
2828 competitors in Breast Cancer
#DrugCompanyPhaseTrials
1Wellcovorin
EEastern Cooperative Oncology Group
Approved
Tykerb
GSKPreclinical
Halaven
EisaiPreclinical
Tecentriq
RochePreclinical
Trodelvy
GileadPreclinical
Adriamycin
GGynecologic Oncology Group
Preclinical
Avastin
BBio-Thera Solutions
Preclinical
Nolvadex
SSan Diego Pacific Oncology & Hematology Associates
Preclinical
Prolia
AmgenPreclinical
Gemzar
GGynecologic Oncology Group
Preclinical
Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.
Timeline
Expected Milestones
Clinical
Trials by Indication[1]
Colorectal Cancer34 trials
Ursodiol, Combination Chemotherapy, and Bevacizumab in Treating Patients With Stage IV Colorectal Cancer
Completed·—·Phase 1·NCT00873275·11 enrolled
Show 31 more trials
Combination Chemotherapy and Monoclonal Antibody Therapy in Treating Patients With Advanced Colorectal Cancer With Liver Metastases or Lung Metastases That Are Potentially Removable by Surgery
Unknown status·—·Phase 2·NCT00513266·35 enrolled
Liver Resection and Floxuridine Plus Fluorouracil and Leucovorin in Treating Patients With Liver Metastases From Colorectal Cancer
Completed·—·Phase 2·NCT00002842·49 enrolled
Pressurized Intraperitoneal Aerosolized Chemotherapy With Mitomycin for the Treatment of Unresectable Appendix or Colorectal Cancer With Peritoneal Metastases, The IMPACT Trial
Not yet recruiting·—·Phase 3·NCT07271355·129 enrolled
Combination Chemotherapy and Oblimersen in Treating Patients With Advanced Colorectal Cancer
Completed·TThe University of Texas Health Science Center at San Antonio·Phase 1/2·NCT00055822·16 enrolled
Metastatic Colorectal Cancer29 trials
Show 26 more trials
Fluorouracil and Leucovorin With or Without Irinotecan in Treating Patients With Metastatic Colorectal Cancer
Completed·EEuropean Organisation for Research and Treatment of Cancer - EORTC·Phase 3·NCT00004885·430 enrolled
Combination Chemotherapy With or Without Celecoxib in Treating Patients With Metastatic Colorectal Cancer
Completed·EEuropean Organisation for Research and Treatment of Cancer - EORTC·Phase 3·NCT00064181·86 enrolled
Radiolabeled Monoclonal Antibody Therapy, Combination Chemotherapy, and Bevacizumab in Treating Patients With Metastatic Colorectal Cancer
Completed·—·Phase 1·NCT01205022·3 enrolled
Ivonescimab and ADG126, Alone, and in Combination With Leucovorin and Fluorouracil or FOLFIRI Regimen for the Treatment of Microsatellite Stable Advanced/Metastatic Colorectal Cancer
Not yet recruiting·—·Phase 1·NCT07363408·30 enrolled
FOLFOX and Bevacizumab in Combination With Botensilimab and Balstilimab (3B-FOLFOX) for the Treatment of Microsatellite Stable (MSS) Metastatic Colorectal Cancer
Active, not recruiting·—·Phase 1/2·NCT05627635·20 enrolled
Combination Chemotherapy in Treating Patients With Metastatic Colorectal Cancer That Cannot Be Removed By Surgery
Unknown status·GGERCOR - Multidisciplinary Oncology Cooperative Group·Phase 2/3·NCT00274872·600 enrolled
Erlotinib, Modified FOLFOX6, and Bevacizumab as First-Line Therapy Metastatic Colorectal Cancer
Completed·—·Phase 1·NCT00118261·17 enrolled
Acute Lymphoblastic Leukemia28 trials
Risk-Adjusted Combination Chemotherapy in Treating Young Patients With Acute Lymphoblastic Leukemia
Unknown status·—·Phase 3·NCT00764907·4,000 enrolled
Show 25 more trials
Imatinib Mesylate and Combination Chemotherapy With or Without a Donor Stem Cell Transplant in Treating Patients With Newly Diagnosed Acute Lymphoblastic Leukemia
Completed·—·Phase 2·NCT00618501·50 enrolled
05-001: Treatment of Acute Lymphoblastic Leukemia in Children
Completed·—·Phase 3·NCT00400946·800 enrolled
Pancreatic Cancer10 trials
Show 7 more trials
Metformin Plus Modified FOLFOX 6 in Metastatic Pancreatic Cancer
Completed·—·Phase 2·NCT01666730·50 enrolled
Gemcitabine Hydrochloride, and Radiation Therapy in Patients With Borderline Resectable Pancreatic Cancer
Terminated·—·Phase 2·NCT01897454·23 enrolled
Leukemia8 trials
Show 5 more trials
57 more indications
Pneumonia7 trials
Lymphoma6 trials
Stage III Colon Cancer5 trials
Esophageal Cancer4 trials
Molecular Phenotyping in Predicting Response in Patients With Stage IB-III Esophageal Cancer Receiving Combination Chemotherapy
Terminated·—·Phase 2·NCT02392377·1 enrolled
Show 1 more trial
Everolimus and Combination Chemotherapy in Treating Patients With Metastatic Stomach or Esophageal Cancer
Completed·—·Phase 1/2·NCT01231399·6 enrolled
Osteosarcoma4 trials
Radiation Therapy3 trials
Patients With Advanced Solid Tumors3 trials
Cancer of the Esophagus2 trials
Advanced Cancer2 trials
Germ Cell Tumor2 trials
Gastroesophageal Junction Cancer2 trials
Rectal Cancer2 trials
Stomach Cancer2 trials
High-Dose Chemotherapy in Treating Patients With Advanced Stomach Cancer
Completed·EEuropean Organisation for Research and Treatment of Cancer - EORTC·Phase 2·NCT00002722·135 enrolled
Locally Advanced2 trials
Colon Cancer2 trials
Patients With Solid Tumors2 trials
Gastric Cancer1 trial
Esophageal Adenocarcinoma1 trial
FOLFOX-6 Induction Chemotherapy Followed by Esophagectomy and Post-operative Chemoradiotherapy in Patients With Esophageal Adenocarcinoma
Unknown status·—·Phase 2·NCT02037048·63 enrolled
Advanced Solid Tumors1 trial
Intraperitoneal Chemotherapy1 trial
Cancer of the Stomach1 trial
Combination Chemotherapy in Treating Patients With Metastatic or Recurrent Cancer of the Stomach or Esophagus
Unknown status·—·Phase 2·NCT00005607
Cancer of Unknown Primary1 trial
Central Nervous System Lymphoma1 trial
Gastroesophageal Junction1 trial
Cancer of the Pancreas1 trial
Imetelstat1 trial
Gallbladder Cancer1 trial
Stage III Rectal Cancer1 trial
Adenocarcinoma1 trial
Advanced Head and Neck Cancer1 trial
Ovarian Cancer1 trial
Biliary Tract Cancer1 trial
Gastrointestinal1 trial
Adjuvant Chemotherapy1 trial
Locally Advanced or Metastatic Solid Tumors1 trial
Organ Preservation1 trial
Azithromycin1 trial
Unresectable Solid Tumor1 trial
Pancreatic Ductal Adenocarcinoma1 trial
Fluorouracil1 trial
Stem Cell Transplantation1 trial
B-cell acute lymphoblastic leukemia1 trial
Glioblastoma Multiforme1 trial
Mycosis Fungoides1 trial
Hodgkin's Disease1 trial
Immunodeficiency1 trial
Chemotherapy1 trial
Metastatic Cancer1 trial
Patients With Locally Advanced Rectal Cancer1 trial
Lymphoblastic Lymphoma1 trial
Pancreatic Adenocarcinoma1 trial
T-cell acute lymphoblastic leukemia1 trial
Stem Cell Transplant1 trial
Donor Stem Cell Transplant After Busulfan, Fludarabine, and Antithymocyte Globulin in Treating Patients With Hematological Cancer
Completed·—·Phase 2·NCT00627666·52 enrolled
Sources
References
- [1]
- [2]MedlinePlus Drug Information — Wellcovorin drug information. U.S. National Library of Medicine, National Institutes of Health.
- [3]
- [4]Open Targets Platform — Drug–disease associations for Leucovorin Calcium. EMBL-EBI & Wellcome Sanger Institute.
- [5]
Details