Platelet-rich fibrin (PRF)

Phase 3Biologic

FFederal University of São Paulo

Platelet-rich fibrin (PRF) is one of 178 biologic programs targeting Alveolar Osteitis. It is currently in Phase 3.

Indications

Total Trials

Active Trials

177

Competitors

Pipeline

Status by Indication[3][1]

Indication

Alveolar OsteitisActive, not recruiting

TreatmentActive, not recruiting

Plantar FasciitisActive, not recruiting

Wound HealingActive, not recruiting

PeriodontitisActive, not recruiting

Impacted Mandibular Third Molar ExtractionRecruiting

Facial SwellingActive, not recruiting

Postoperative RecoveryCompleted

Platelet-Rich FibrinCompleted

AgeCompleted

Alveolar OsteitisPreclinical

Active, not recruiting

TreatmentPreclinical

Active, not recruiting

Plantar FasciitisPreclinical

Active, not recruiting

Wound HealingPreclinical

Active, not recruiting

PeriodontitisPreclinical

Active, not recruiting

Impacted Mandibular Third Molar ExtractionPreclinical

Recruiting

Facial SwellingPreclinical

Active, not recruiting

Postoperative RecoveryPreclinical

Completed

Platelet-Rich FibrinPreclinical

Completed

AgePreclinical

Completed

Showing 10 of 13 indications

Competition

Competitive Landscape

350 competitors in Treatment

#DrugCompanyPhaseTrials

Platelet-rich fibrin (PRF)

FFederal University of São Paulo

Phase 3

1 2

Alfenta

Jazz Pharmaceuticals

Preclinical

1 3

Theo-Dur

Pfizer

Preclinical

1 4

Levulan

Sun Pharmaceutical Industries, Inc.

Preclinical

1 5

Lamprene

Novartis

Preclinical

1 6

Emtriva

Gilead

Preclinical

1 7

Foscavir

CClinigen, Inc.

Preclinical

6 8

Valium

Akero Therapeutics

Preclinical

2 9

Reminyl

WWim Janssens

Preclinical

1 10

Brevibloc

MMcNeil Consumer & Specialty Pharmaceuticals, a Division of McNeil-PPC, Inc.

Preclinical

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q3 2026

Phase 1Active, not recruiting

Papilla Reconstruction

NCT07280507

Q4 2026

PreclinicalActive, not recruiting

Alveolar Osteitis

NCT07790653

PreclinicalActive, not recruiting

Facial Swelling

NCT07764757

Q3 2027

Post-ApprovalNot yet recruiting

Osteoarthritis

NCT06905860

Q1 2028

N/ARecruiting

Plantar Fasciitis

NCT07242729

Clinical

Trials by Indication[1]

Platelet-rich Fibrin2 trials

Comparison of Hyaluronic Acid, Injectable Platelet-Rich Fibrin, and Prolotherapy in TMJ Arthrocentesis

Completed·OOndokuz Mayıs University·N/A·NCT07479693·36 enrolled

Study on Platelet-Rich Fibrin for Preserving Jawbone After Tooth Extraction Using CBCT Imaging in Adults

Completed·—·N/A·NCT07022860·12 enrolled

Wound Healing2 trials

Comparison of I-PRF, T-PRF, and 0.8% Hyaluronic Acid Applications in Wound Healing After Gingivectomy.

Active, not recruiting·SSaglik Bilimleri Universitesi·N/A·NCT06865092·60 enrolled

Evaluation of the Effectiveness of Different Procedures on Palatinal Wound Healing After Free Gingival Graft Surgery.

Completed·SSEVAL CEYLAN ŞEN·N/A·NCT06867055·67 enrolled

ACL Reconstruction1 trial

Sensory Deficit Following ACL Reconstruction: PRF Pilot Study

Completed·UUniversity of Belgrade··NCT07257666·53 enrolled

Orthodontic Tooth Movement1 trial

Evaluation of Different Orthodontic Tooth Movements Assisted With Injectable Platelet Rich Fibrin

Unknown status·—·Phase 1/2·NCT05616936·54 enrolled

Age1 trial

Effect of i-PRF and LLLT on Free Gingival Graft Shrinkage

Completed·KKahramanmaras Sutcu Imam University·N/A·NCT07303192·48 enrolled

20 more indications

Papilla Reconstruction1 trial

Comparing Microneedling and Injectable Platelet Rich Fibrin to Hyaluronic Acid In Papilla Reconstruction

Active, not recruiting·KKing Abdulaziz University·Phase 1·NCT07280507·7 enrolled

Maxillary Canine Retraction1 trial

Assesment of Two Different Modalities of Maxillary Canine Retraction Assisted With Injectable Platelet Rich Fibrin

Unknown status·—·Phase 1·NCT05429437·18 enrolled

Postoperative Recovery1 trial

Effects of Platelet-Rich Fibrin and Kinesio Taping on Postoperative Recovery in Oral Surgery

Completed·MMustafa Kemal University·N/A·NCT06900894·44 enrolled

Bone1 trial

Computer Guided Versus Conventional Augmentation Using Bone Ring

Unknown status·—·N/A·NCT03049137·10 enrolled

Morbidity1 trial

Patient Morbidity After Palatal Free Gingival Grafts With or Without PRF Membranes Coverage

Completed·AAzienda Ospedaliera San Paolo·N/A·NCT03685396·42 enrolled

MPA1 trial

Periodontal Regeneration Using Vitamin A and PRF Compared to PRF Alone Treating Intra-bony Defects

Unknown status·—·N/A·NCT05285293·28 enrolled

Periodontitis1 trial

Evaluation of Repeated Injectable PRF Following SRP in Patients With Periodontitis

Completed·SSaglik Bilimleri Universitesi·N/A·NCT07029035·20 enrolled

Treatment1 trial

Injectable PRF in Non-Surgical Periodontal Treatment

Active, not recruiting·—·N/A·NCT07375004·13 enrolled

Plantar Fasciitis1 trial

Bone Marrow Aspirate Versus Platelet-Rich Fibrin for the Treatment of Chronic Plantar Fasciitis

Recruiting·FFederal University of São Paulo·N/A·NCT07242729·72 enrolled

Socket Preservation1 trial

Effects of Autogenous Dentin Graft on Socket Preservation

Completed·—·Phase 4·NCT04131894·9 enrolled

Chronic Leg Ulcer1 trial

Efficacy of Platelet-rich-Fibrin Gel in Patients With Chronic Leg Ulcers

Recruiting·PPak Emirates Military Hospital·Phase 1·NCT07294521·40 enrolled

Osteoarthritis1 trial

Intra-articular Infiltration of Platelet-Rich Fibrin vs Corticosteroid in Mild to Moderate Knee Osteoarthritis

Not yet recruiting·FFederal University of São Paulo·Phase 4·NCT06905860·90 enrolled

Alveolar Osteitis1 trial

A Comparative Study of the Healing Status by the Use of Alvogyl and Platelet-Rich Fibrin in the Treatment of Alveolar Osteitis: A Randomized Double-Blind Controlled Clinical Trial

Active, not recruiting·CCMH Lahore Medical College and Institute of Dentistry·Preclinical·NCT07790653·102 enrolled

Tooth Extraction1 trial

Clinical and Histological Evaluation of the Efficacy of Autogenous Dentin Graft in Extraction Socket Preservation

Completed·AAnkara Yildirim Beyazıt University·Preclinical·NCT07789262·9 enrolled

Facial Swelling1 trial

Effects of Antibiotic-Prepared Platelet-Rich Fibrin on Postoperative Recovery After Mandibular Third Molar Surgery: A Randomized Split-Mouth Clinical Trial

Active, not recruiting·AAmerigo Giudice·Preclinical·NCT07764757·31 enrolled

Impacted Mandibular Third Molar Extraction1 trial

Comparison of Postoperative Effects of PRF and Corticosteroid Treatments in Impacted Third Molar Surgery

Recruiting·FFinal International University·Preclinical·NCT07742826·60 enrolled

Temporomandibular Disorder1 trial

Assessment of the Effectiveness of Intra-articular Injectable Platelet-rich Fibrin (iPRF) Injections in the Management of Mild and Moderate Degeneration of the Temporomandibular Joints

Enrolling by invitation·WWroclaw Medical University·Preclinical·NCT05214924·42 enrolled

Atrophy1 trial

Alveolar Ridge Splitting Augmented With Simvastatin/Platelet-Rich Fibrin Composite With Simultaneous Implant Placement in Horizontal Ridge Augmentation: A Randomized Controlled Clinical Trial

Completed·MMaruwan Ali Alteer·Preclinical·NCT07692620·21 enrolled

Impacted Mandibular Third Molar1 trial

Evaluation of the Effects of Platelet-Rich Fibrin on Postoperative Pain, Trismus, and Edema Following Surgical Removal of Mandibular Third Molars

Completed·PPAEC General Hospital, Islamabad·Preclinical·NCT07672951·134 enrolled

Unspecified2 trials

i-PRF & Root Surface Biomodification

Completed·HHalil Ata BIÇAKÇIOGLU·N/A·NCT07207668·42 enrolled

Effect of Injectable Platelet Rich Derivatives on Orthodontic Canine Retraction

Completed·SSana'a University·N/A·NCT07408895·21 enrolled

Sources

References

[1]
ClinicalTrials.gov — 28 trial records for Platelet-rich fibrin (PRF). U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — Platelet-rich fibrin (PRF) compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for Platelet-rich fibrin (PRF). EMBL-EBI & Wellcome Sanger Institute.
[4]
SEC EDGAR — Federal University of São Paulo company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Biologic[2]
Highest Phase: Phase 3[1]
Company: FFederal University of São Paulo

Platelet-rich fibrin (PRF)

Status by Indication[3][1]

Competitive Landscape

Expected Milestones

Q3 2026

Q4 2026

Q3 2027

Q1 2028

Trials by Indication[1]

Platelet-rich Fibrin2 trials

Wound Healing2 trials

ACL Reconstruction1 trial

Orthodontic Tooth Movement1 trial

Age1 trial

Papilla Reconstruction1 trial

Maxillary Canine Retraction1 trial

Postoperative Recovery1 trial

Bone1 trial

Morbidity1 trial

MPA1 trial

Periodontitis1 trial

Treatment1 trial

Plantar Fasciitis1 trial

Socket Preservation1 trial

Chronic Leg Ulcer1 trial

Osteoarthritis1 trial

Alveolar Osteitis1 trial

Tooth Extraction1 trial

Facial Swelling1 trial

Impacted Mandibular Third Molar Extraction1 trial

Temporomandibular Disorder1 trial

Atrophy1 trial

Impacted Mandibular Third Molar1 trial

Unspecified2 trials

References

Drug Info

Quick Facts

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