Benemid

(Probenecid)

ApprovedSmall molecule

CCidara Therapeutics Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)

Benemid is a small molecule that works as a Solute Carrier Family 22 Member 11 Inhibitor; Solute Carrier Family 22 Member 6 Inhibitor; Solute Carrier Family 22 Member 8 Inhibitor.[2] It is being used across 19 indications, with its most advanced program in Approved.[1]

Benemid is one of 438 small molecule programs targeting Gout. It is currently in Approved.

Indications

Total Trials

Active Trials

437

Competitors

FDA Application

NDA/BLA/ANDA regulatory filings

Pipeline

Status by Indication[3][1]

Indication

GoutActive, not recruiting

ChondrocalcinosisApproved

Alcohol DependenceApproved

Systolic Heart FailureApproved

ObesityApproved

Brain InjuryApproved

Type 2 Diabetes MellitusApproved

Kidney DiseaseApproved

COVID-19Approved

Partial EpilepsyApproved

GoutApproved

Active, not recruiting

ChondrocalcinosisApproved

Approved

Alcohol DependenceApproved

Approved

Systolic Heart FailureApproved

Approved

ObesityApproved

Approved

Brain InjuryApproved

Approved

Type 2 Diabetes MellitusApproved

Approved

Kidney DiseaseApproved

Approved

COVID-19Approved

Approved

Partial EpilepsyApproved

Approved

Showing 10 of 19 indications

Competition

Competitive Landscape

317 competitors in COVID-19

#DrugCompanyPhaseTrials

Benemid

CCidara Therapeutics Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)

Approved

44 2

Nitrostat

VViatris Specialty LLC

Preclinical

1 3

Biological Collection

AAssistance Publique - Hôpitaux de Paris

Preclinical

1 4

Blood Taken

HHospices Civils de Lyon

Preclinical

1 5

Antihypertensive Agents

NNational Heart, Lung, and Blood Institute (NHLBI)

Preclinical

1 6

Pfizer-COVID-19 Vaccine

Moderna

Preclinical

1 7

Hymecromone

SStanford University

Preclinical

1 8

Proventil

Mylan Pharmaceuticals Inc

Preclinical

1 9

Netakimab

SSPH-BIOCAD (HK) Limited

Preclinical

1 10

NO Inhalation

SShanghai Zhongshan Hospital

Preclinical

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q4 2026

Phase 1Active, not recruiting

Study completion

NCT07661108

Q1 2029

Phase 2Not yet recruiting

Epilepsy

NCT07318870

Q4 2030

Phase 2Recruiting

Alcohol

NCT07118618

Clinical

Trials by Indication[1]

NEC6 trials

Study to Evaluate Effects of Probenecid, Rifampin and Verapamil on Bexagliflozin in Healthy Subjects

Completed· Theracos logo

Theracos·Phase 1·NCT03296800·48 enrolled

A Study in Healthy People to Test How 2 Different Formulations of BI 690517 Are Taken up in the Body and How Probenecid Influences the Amount of BI 690517 in the Blood

Completed· Boehringer Ingelheim logo

Boehringer Ingelheim·Phase 1·NCT06647810·15 enrolled

Addition of Probenecid to Penicillin-V Therapy

Completed·IImperial College London·Phase 1/2·NCT05082909·21 enrolled

Show 3 more trials

Effects of Rifampicin and Probenecid On The Pharmacokinetic Profile Of Rongliflozin In Healthy Subjects

Completed· Sunshine Lake Pharma Co., Ltd. logo

Sunshine Lake Pharma Co., Ltd.·Phase 1·NCT05497674·28 enrolled

Effect of Probenecid on Synovial Fluid ATP Levels in CPPD

Completed·VVA Office of Research and Development·Phase 1·NCT02243631·8 enrolled

AV-101 Alone and in Combination With Probenecid in Healthy Subjects

Unknown status·VVistaGen Therapeutics, Inc.·Phase 1·NCT05280054·24 enrolled

Tics3 trials

Influence of Probenecid and Quinine on the Pharmacokinetics of Azidothymidine

Completed·NNational Institute of Allergy and Infectious Diseases (NIAID)·N/A·NCT00000706·12 enrolled

A Study to Assess Pharmacokinetics of PF-04965842 and Its Metabolites and Effect of Probenecid in Healthy Participants

Completed· Pfizer logo

Pfizer·Phase 1·NCT03937258·12 enrolled

Effect of Probenecid on Pexidartinib Pharmacokinetics

Completed· Daiichi Sankyo logo

Daiichi Sankyo·Phase 1·NCT03138759·16 enrolled

Interaction3 trials

Drug-durg Interaction of ZSP1273 With Digoxin, Rosuvastatin,Itraconazole and Probenecid

Completed·GGuangdong Raynovent Biotech Co., Ltd·Phase 1·NCT05954624·49 enrolled

Drug-Drug Interaction Study of Vadadustat With Cyclosporine, Probenecid and Rifampin

Completed·AAkebia Therapeutics·Phase 1·NCT03801746·40 enrolled

Pharmacokinetic Drug-Drug Interaction Study to Identify Biomarkers of Kidney Transporters

Completed·WWashington State University·Phase 1·NCT05365451·16 enrolled

Retinitis2 trials

HPMPC (Cidofovir) Peripheral CMV Retinitis Trial Protocol

Completed·NNational Institute of Allergy and Infectious Diseases (NIAID)·N/A·NCT00000799·100 enrolled

Comparison of Two Drugs, Cidofovir and Ganciclovir, in Treating Patients With AIDS Who Have CMV Retinitis

Completed·NNational Institute of Allergy and Infectious Diseases (NIAID)·Phase 4·NCT00000894·300 enrolled

Cytomegalovirus (CMV)2 trials

The Safety and Effectiveness of Cidofovir in the Treatment of Cytomegalovirus (CMV) of the Eyes in Patients With AIDS

Completed· Gilead logo

Gilead·Phase 2·NCT00002437·48 enrolled

A Study of Cidofovir in HIV-Infected Children With Cytomegalovirus (CMV) Disease

Withdrawn·NNational Institute of Allergy and Infectious Diseases (NIAID)·Phase 1·NCT00000881

26 more indications

Pathophysiology1 trial

Biodistribution and Pathophysiology Study of 11C-para-aminobenzoic Acid

Completed·JJohns Hopkins University··NCT05611905·13 enrolled

Phase 11 trial

A Phase 1 Study to Evaluate the Effect of the Organic Anion Transporter Inhibitor Probenecid on the Pharmacokinetics of JNJ-64041575 in Healthy Adults

Completed· Johnson & Johnson logo

Johnson & Johnson·Phase 1·NCT03105986·18 enrolled

Fontan1 trial

TRPV2 Agonists in the Fontan Circulation

Completed·—·Phase 4·NCT03965351·8 enrolled

Completed·MM.D. Anderson Cancer Center·Phase 1·NCT01816646·6 enrolled

Cytomegalovirus Retinitis1 trial

An Open-Label Study of the Safety and Efficacy of Cidofovir for the Treatment of Relapsing Cytomegalovirus Retinitis in Patients With AIDS

Completed· Gilead logo

Gilead·N/A·NCT00002142·100 enrolled

Vitamin D1 trial

Study of Vitamin D and Uric Acid Lowering on Kidney and Blood Vessel Function

Completed·—·Phase 3·NCT01320722·242 enrolled

Epilepsy1 trial

Efficacy of Probenecid on Cluster Seizures During Anti Seizure Medication Withdrawal in Presurgical Focal Epilepsy Video-EEG Monitoring

Not yet recruiting·FFondation Ophtalmologique Adolphe de Rothschild·Phase 2·NCT07318870·600 enrolled

AIN1 trial

This Study Tests the Effect of Certain Medicines on the Transport of Other Medicines in the Body of Healthy Men

Completed· Boehringer Ingelheim logo

Boehringer Ingelheim·Phase 1·NCT03307252·45 enrolled

Baricitinib1 trial

A Study of Baricitinib and Probenecid in Healthy Participants

Completed· Eli Lilly logo

Eli Lilly·Phase 1·NCT01937026·18 enrolled

Concentration1 trial

A Trial Investigating the Effect of Probenecid and Ciclosporin on the Concentrations of SNAC in Healthy Subjects

Completed· Novo Nordisk logo

Novo Nordisk·Phase 1·NCT03466567·21 enrolled

Progressive Multifocal Leukoencephalopathy1 trial

A Study to Evaluate the Use of Cidofovir (an Experimental Drug) for the Treatment of Progressive Multifocal Leukoencephalopathy (PML) in AIDS Patients

Completed·NNational Institute of Allergy and Infectious Diseases (NIAID)·N/A·NCT00000945·24 enrolled

Drug Repurposing1 trial

Data Analysis for Drug Repurposing for Effective Alzheimer's Medicines - (DREAM) Probenecid vs Allopurinol

Completed·—··NCT04746989·294,878 enrolled

Opioid Withdrawal1 trial

Novel Use of Probenecid to Alleviate Symptoms of Opioid Withdrawal

Recruiting·UUniversity of Calgary·Phase 2·NCT04939623·40 enrolled

ESS1 trial

A Study to Learn About How the Study Medicines Called Itraconazole and Probenecid Change How the Body Processes PF-07220060

Recruiting· Pfizer logo

Pfizer·Phase 1·NCT07160738·28 enrolled

Drug1 trial

Evaluation of Renal Drug Transport in Healthy Volunteers

Completed·UUniversity of Maryland, Baltimore·N/A·NCT00690014·10 enrolled

Metformin1 trial

A Study to Assess the Effect of Povorcitinib on Digoxin, Rosuvastatin, and Metformin Pharmacokinetics and the Effect of Probenecid on Povorcitinib Pharmacokinetics When Administered Orally to Healthy Adult Participants

Completed· Incyte logo

Incyte·Phase 1·NCT06416800·71 enrolled

Alcohol1 trial

Probenecid Administration for Alcohol Craving and Consumption

Recruiting·—·Phase 2·NCT07118618·120 enrolled

Oral1 trial

A Relative Bioavailability Study With a Novel PanCytoVir™ Oral Suspension (100 mg/ml)

Completed·TTrippBio, Inc.·Phase 1·NCT06025344·14 enrolled

HIV Pre-Exposure Prophylaxis1 trial

Assessment of a New "Boosting" Strategy for HIV Pre-exposure Prophylaxis in Healthy Volunteers

Completed·IIndiana University·Phase 1·NCT03202511·15 enrolled

Drug Interactions1 trial

A Study to Evaluate the Drug-drug Interactions (DDIs) of DBPR108 With Warfarin Sodium, Digoxin, Probenecid in Healthy Subjects

Completed· CSPC ZhongQi Pharmaceutical Technology Co., Ltd. logo

CSPC ZhongQi Pharmaceutical Technology Co., Ltd.·Phase 1·NCT05045313·28 enrolled

Empagliflozin1 trial

Drug-interaction Trial in Healthy Subjects With Oral Administration of Empagliflozin (BI 10773), Rifampicin and Probenecid

Completed· Boehringer Ingelheim logo

Boehringer Ingelheim·Phase 1·NCT01634100·18 enrolled

Heart Failure1 trial

Treatment of Veterans With Heart Failure With Reduced Ejection Fraction With Probenecid

Completed·VVA Office of Research and Development·Preclinical·NCT04551222·125 enrolled

Unspecified3 trials

Evaluation of Alternative Oseltamivir (Tamiflu) Dosing Strategies.

Completed·UUS Department of Veterans Affairs·Phase 4·NCT00304434·48 enrolled

Pharmacologic Study of Oseltamivir in Healthy Volunteers

Completed·MMahidol University·Phase 1·NCT00439530·21 enrolled

An Open-label, Phase 1 Study to Individually Characterize the Food Effect, the Drug-Drug Interaction Effect of OAT Inhibition, and the Drug-Drug Interaction Effect of P-glycoprotein Inhibition on the Pharmacokinetics of MK-8527 in Healthy Adult Participants

Active, not recruiting· Merck & Co. logo

Merck & Co.·Phase 1·NCT07661108·44 enrolled

Regulatory

FDA Approval Timeline[4]

Jan 1, 1982

BENEMID

NDA NDA007898

Sources

References

[1]
ClinicalTrials.gov — 44 trial records for Probenecid. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — Probenecid compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for Probenecid. EMBL-EBI & Wellcome Sanger Institute.
[4]
OpenFDA — FDA approval records (NDA NDA007898). U.S. Food & Drug Administration.
[5]
SEC EDGAR — Cidara Therapeutics Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA) company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Mechanism of Action: Solute Carrier Family 22 Member 11 Inhibitor; Solute Carrier Family 22 Member 6 Inhibitor; Solute Carrier Family 22 Member 8 Inhibitor[2]
Modality: Small molecule[2]
Highest Phase: Approved[1]
Company: CCidara Therapeutics Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)

Benemid

Status by Indication[3][1]

Competitive Landscape

Expected Milestones

Q4 2026

Q1 2029

Q4 2030

Trials by Indication[1]

NEC6 trials

Tics3 trials

Interaction3 trials

Retinitis2 trials

Cytomegalovirus (CMV)2 trials

Pathophysiology1 trial

Phase 11 trial

Fontan1 trial

Patients With Advanced Solid Tumors1 trial

Hypertension1 trial

Tolerance1 trial

Cystitis1 trial

Cytomegalovirus Retinitis1 trial

Vitamin D1 trial

Epilepsy1 trial

AIN1 trial

Baricitinib1 trial

Concentration1 trial

Progressive Multifocal Leukoencephalopathy1 trial

Drug Repurposing1 trial

Opioid Withdrawal1 trial

ESS1 trial

Drug1 trial

Metformin1 trial

Alcohol1 trial

Oral1 trial

HIV Pre-Exposure Prophylaxis1 trial

Drug Interactions1 trial

Empagliflozin1 trial

Heart Failure1 trial

Unspecified3 trials

FDA Approval Timeline[4]

References

Drug Info

Quick Facts

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