Propolis

Phase 3Small molecule

Propolis is one of 122 small molecule programs targeting Chemotherapy-Induced Oral Mucositis. It is currently in Phase 3.

Indications

Total Trials

Active Trials

121

Competitors

Pipeline

Status by Indication[3][1]

Indication

Chemotherapy-Induced Oral MucositisNot yet recruiting

PeriodontitisActive, not recruiting

EfficacyCompleted

IganUnknown status

Diabetic Foot UlcerNot yet recruiting

CholesterolRecruiting

Diabetic FootActive, not recruiting

Chemotherapy-Induced Oral MucositisPhase 2

Not yet recruiting

PeriodontitisPreclinical

Active, not recruiting

EfficacyPreclinical

Completed

IganPreclinical

Unknown status

Diabetic Foot UlcerPreclinical

Not yet recruiting

CholesterolPhase 3

Recruiting

Diabetic FootPreclinical

Active, not recruiting

Competition

Competitive Landscape

139 competitors in Efficacy

#DrugCompanyPhaseTrials

Rayos

RRoxane Laboratories

Phase 3

5 2

Paraplatin

AAvyxa

Phase 3

4 3

Alimta

SShawn Eagle

Phase 3

3 4

Cytoxan

BBaxter Healthcare Corporation

Phase 3

3 5

Pifeltro

CCidara Therapeutics Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)

Phase 3

1 6

Propolis

IIndonesia University

Phase 3

2 7

Cetaphil

GGalderma R&D

Phase 3

1 8

Levocept

SSebela Women's Health Inc.

Phase 3

1 9

Veracept

SSebela Women's Health Inc.

Phase 3

1 10

Primaquine

Sanofi

Preclinical

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q3 2027

PreclinicalNot yet recruiting

Diabetic Foot Ulcer

NCT07099482

Clinical

Trials by Indication[1]

Efficacy2 trials

Efficacy of a Mouthwash Containing Propolis

Unknown status·FFederal University of Minas Gerais·Phase 3·NCT01750801·2 enrolled

Efficacy of Desensitizing Agent,Propolis After an In-office Vital Tooth Bleaching.

Completed·—·N/A·NCT05569590·90 enrolled

Treatment2 trials

Role of Propolis Paste in Preventing Pain After Root Canal Treatment.

Completed·JJuzer Shabbir Saifee·Phase 3·NCT03723980·80 enrolled

Propolis as a Treatment Option for Hand Foot and Mouth Disease

Completed·MMurat Sutcu·Phase 2/3·NCT06455007·200 enrolled

Chemotherapy-Induced Oral Mucositis1 trial

Propolis for Management of Chemotherapy-Induced Oral Mucositis in Pediatric Patients

Not yet recruiting·—·Phase 2·NCT07073092·50 enrolled

Mucositis1 trial

Assessing the Preventing and Therapeutic Effect of Propolis in Radiotherapy Induced Mucositis of Head and Neck Cancers

Completed·MMashhad University of Medical Sciences·Phase 2·NCT01375088·20 enrolled

Endometriosis1 trial

Effects of Sulawesi Propolis Extract on Lesion Growth, Apoptotic and Inflammatory Activity of the Rat Endometriosis Tissue

Completed·IIndonesia University·Phase 1·NCT04374006·120 enrolled

12 more indications

IgAN1 trial

Using Three Different Final Irrigants and Showing Their Effects on the Success of Revascularization

Unknown status·—·N/A·NCT03591172·75 enrolled

Chronic Kidney Disease1 trial

Propolis Effects in Patients With Chronic Kidney Disease

Completed·UUniversity of Sao Paulo General Hospital·Phase 2·NCT02766036·32 enrolled

Chronic Periodontitis1 trial

Propolis Improves Glycemic Control in Subjects With Type 2 Diabetes and Chronic Periodontitis

Completed·MMohamed Anees·Phase 4·NCT02794506·52 enrolled

Hypersensitivity1 trial

A Comparative Study On The Effect Of Propolis And Dentine Bonding Agent In Treating Dentine Hypersensitivity

Completed·—·Phase 1·NCT04754763·52 enrolled

Mineral Trioxide Aggregate1 trial

Postoperative Pain Evaluation of Mineral Trioxide Aggregate and Propolis After Pulpotomy in Carious Primary Molars

Unknown status·—·Phase 2·NCT03580135·28 enrolled

Diabetic Foot1 trial

Propolis as Adjuvant in the Healing of Human Diabetic Foot Wounds

Completed·UUniversity of Talca··NCT03649243·31 enrolled

Oncology Patients1 trial

Oral Care With Propolis in Pediatric Oncology Patients

Completed·IIzmir Katip Celebi University·N/A·NCT05400031·108 enrolled

Cholesterol1 trial

The Effect of Propolis Administration on Cholesterol Level in Diabetic Type 2 Patients

Recruiting·IIndonesia University·Phase 4·NCT06903546·64 enrolled

Type 2 Diabetes Mellitus1 trial

Effect of Propolis or Metformin Administration on Glycemic Control in Patients With Type 2 Diabetes Mellitus

Completed·UUniversity of Guadalajara·Phase 2·NCT03416127·36 enrolled

Periodontitis1 trial

Propolis In The Treatment Of Periodontitis

Unknown status·—·N/A·NCT01943877·20 enrolled

Dentin Hypersensitivity1 trial

Comparison Of The Effect Of Propolis And Gluma Desensitizer On The Management Of Dentin Hypersensitivity

Completed·—·Phase 2/3·NCT04819867·40 enrolled

Diabetic Foot Ulcer1 trial

Effectiveness of Propolis Phonophoresis on Wound Healing in Diabetic Ulcer: a Randomized Controlled Trial

Not yet recruiting·SSinai University·Preclinical·NCT07099482·80 enrolled

Sources

References

[1]
ClinicalTrials.gov — 19 trial records for Propolis. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — Propolis compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for Propolis. EMBL-EBI & Wellcome Sanger Institute.
[4]
SEC EDGAR — Indonesia University company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[2]
Highest Phase: Phase 3[1]
Company: IIndonesia University

Propolis

Status by Indication[3][1]

Competitive Landscape

Expected Milestones

Q3 2027

Trials by Indication[1]

Efficacy2 trials

Treatment2 trials

Chemotherapy-Induced Oral Mucositis1 trial

Mucositis1 trial

Endometriosis1 trial

IgAN1 trial

Chronic Kidney Disease1 trial

Chronic Periodontitis1 trial

Hypersensitivity1 trial

Mineral Trioxide Aggregate1 trial

Diabetic Foot1 trial

Oncology Patients1 trial

Cholesterol1 trial

Type 2 Diabetes Mellitus1 trial

Periodontitis1 trial

Dentin Hypersensitivity1 trial

Diabetic Foot Ulcer1 trial

References

Drug Info

Quick Facts

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