Propolis

ApprovedSmall molecule

IIndonesia University

Propolis is one of 232 small molecule programs targeting Mucositis. It is currently in Approved.

Indications

Total Trials

Active Trials

231

Competitors

Pipeline

Status by Indication[3][1]

Indication

MucositisActive, not recruiting

Type 2 Diabetes MellitusActive, not recruiting

Chemotherapy-Induced Oral MucositisActive, not recruiting

Chronic PeriodontitisActive, not recruiting

PeriodontitisActive, not recruiting

Chronic Kidney DiseaseActive, not recruiting

EndometriosisActive, not recruiting

Diabetic FootActive, not recruiting

MucositisPhase 2

Active, not recruiting

Type 2 Diabetes MellitusPhase 2

Active, not recruiting

Chemotherapy-Induced Oral MucositisPhase 2

Active, not recruiting

Chronic PeriodontitisApproved

Active, not recruiting

PeriodontitisPreclinical

Active, not recruiting

Chronic Kidney DiseasePhase 2

Active, not recruiting

EndometriosisPhase 1

Active, not recruiting

Diabetic FootPreclinical

Active, not recruiting

Competition

Competitive Landscape

676 competitors in Type 2 Diabetes Mellitus

#DrugCompanyPhaseTrials

Propolis

IIndonesia University

Approved

1 2

Byetta

AstraZeneca

Preclinical

20 3

Tanzeum

GSK

Preclinical

10 4

Insulin 320

Novo Nordisk

Preclinical

43 5

NOVOLIN R

Novo Nordisk

Preclinical

1 6

Adenocard

Astellas

Preclinical

1 7

Dostinex

Golytely

Cipro

Myrbetriq

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q3 2026

N/ANot yet recruiting

Diabetic Foot

NCT07099482

Clinical

Trials by Indication[1]

Treatment2 trials

Propolis as a Treatment Option for Hand Foot and Mouth Disease

Completed·MMurat Sutcu·Phase 2/3·NCT06455007·200 enrolled

Role of Propolis Paste in Preventing Pain After Root Canal Treatment.

Completed·JJuzer Shabbir Saifee·Phase 3·NCT03723980·80 enrolled

Efficacy2 trials

Efficacy of Desensitizing Agent,Propolis After an In-office Vital Tooth Bleaching.

Completed·—·N/A·NCT05569590·90 enrolled

Efficacy of a Mouthwash Containing Propolis

Unknown status·FFederal University of Minas Gerais·Phase 3·NCT01750801·2 enrolled

Diabetic Foot2 trials

Propolis as Adjuvant in the Healing of Human Diabetic Foot Wounds

Completed·UUniversity of Talca··NCT03649243·31 enrolled

"Ultrasound-Enhanced Propolis Therapy for Healing Diabetic Foot Wounds"

Not yet recruiting·SSinai University·N/A·NCT07099482·80 enrolled

Endometriosis1 trial

Effects of Sulawesi Propolis Extract on Lesion Growth, Apoptotic and Inflammatory Activity of the Rat Endometriosis Tissue

Completed·IIndonesia University·Phase 1·NCT04374006·120 enrolled

IgAN1 trial

Using Three Different Final Irrigants and Showing Their Effects on the Success of Revascularization

Unknown status·—·N/A·NCT03591172·75 enrolled

11 more indications

Oncology Patients1 trial

Oral Care With Propolis in Pediatric Oncology Patients

Completed·IIzmir Katip Celebi University·N/A·NCT05400031·108 enrolled

Chemotherapy-Induced Oral Mucositis1 trial

Propolis for Management of Chemotherapy-Induced Oral Mucositis in Pediatric Patients

Not yet recruiting·—·Phase 2·NCT07073092·50 enrolled

Chronic Kidney Disease1 trial

Propolis Effects in Patients With Chronic Kidney Disease

Completed·UUniversity of Sao Paulo General Hospital·Phase 2·NCT02766036·32 enrolled

Chronic Periodontitis1 trial

Propolis Improves Glycemic Control in Subjects With Type 2 Diabetes and Chronic Periodontitis

Completed·MMohamed Anees·Phase 4·NCT02794506·52 enrolled

Type 2 Diabetes Mellitus1 trial

Effect of Propolis or Metformin Administration on Glycemic Control in Patients With Type 2 Diabetes Mellitus

Completed·UUniversity of Guadalajara·Phase 2·NCT03416127·36 enrolled

Cholesterol1 trial

The Effect of Propolis Administration on Cholesterol Level in Diabetic Type 2 Patients

Recruiting·IIndonesia University·Phase 4·NCT06903546·64 enrolled

Mucositis1 trial

Assessing the Preventing and Therapeutic Effect of Propolis in Radiotherapy Induced Mucositis of Head and Neck Cancers

Completed·MMashhad University of Medical Sciences·Phase 2·NCT01375088·20 enrolled

Hypersensitivity1 trial

A Comparative Study On The Effect Of Propolis And Dentine Bonding Agent In Treating Dentine Hypersensitivity

Completed·—·Phase 1·NCT04754763·52 enrolled

Mineral Trioxide Aggregate1 trial

Postoperative Pain Evaluation of Mineral Trioxide Aggregate and Propolis After Pulpotomy in Carious Primary Molars

Unknown status·—·Phase 2·NCT03580135·28 enrolled

Periodontitis1 trial

Propolis In The Treatment Of Periodontitis

Unknown status·—·N/A·NCT01943877·20 enrolled

Dentin Hypersensitivity1 trial

Comparison Of The Effect Of Propolis And Gluma Desensitizer On The Management Of Dentin Hypersensitivity

Completed·—·Phase 2/3·NCT04819867·40 enrolled

Sources

References

[1]
ClinicalTrials.gov — 19 trial records for Propolis. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — Propolis compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for Propolis. EMBL-EBI & Wellcome Sanger Institute.
[4]
SEC EDGAR — Indonesia University company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[2]
Highest Phase: Approved[1]
Company: IIndonesia University

Propolis

Status by Indication[3][1]

Competitive Landscape

Expected Milestones

Q3 2026

Trials by Indication[1]

Treatment2 trials

Efficacy2 trials

Diabetic Foot2 trials

Endometriosis1 trial

IgAN1 trial

Oncology Patients1 trial

Chemotherapy-Induced Oral Mucositis1 trial

Chronic Kidney Disease1 trial

Chronic Periodontitis1 trial

Type 2 Diabetes Mellitus1 trial

Cholesterol1 trial

Mucositis1 trial

Hypersensitivity1 trial

Mineral Trioxide Aggregate1 trial

Periodontitis1 trial

Dentin Hypersensitivity1 trial

References

Drug Info

Quick Facts

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