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Quercetin

Phase 3Small molecule

Quercetin is a natural compound found in plants that is used as a dietary supplement to reduce inflammation and support immune function, though scientific evidence for its effectiveness is still being studied.[1] Quercetin is currently being investigated across 10 indications[3], with its most advanced program in Phase 3.[1]

Quercetin is one of 182 small molecule programs targeting Dyskeratosis Congenita. It is currently in Phase 3.

10

Indications

31

Total Trials

12

Active Trials

181

Competitors

Pipeline

Status by Indication[3][1]

Indication

Dyskeratosis CongenitaRecruiting

Polycystic Ovary SyndromeRecruiting

Breast CancerRecruiting

ObesityUnknown

Mental DisordersActive, not recruiting

T CellsRecruiting

Recurrent Multiple MyelomaRecruiting

Mild Cognitive ImpairmentActive, not recruiting

Phase IIRecruiting

PtosisRecruiting

Dyskeratosis CongenitaPhase 1

Recruiting

Polycystic Ovary SyndromePhase 2

Recruiting

Breast CancerPhase 2

Recruiting

ObesityPreclinical

Unknown

Mental DisordersPhase 2

Active, not recruiting

T CellsPhase 3

Recruiting

Recurrent Multiple MyelomaPhase 2

Recruiting

Mild Cognitive ImpairmentPreclinical

Active, not recruiting

Phase IIPhase 2

Recruiting

PtosisPhase 1

Recruiting

Competition

Competitive Landscape

702 competitors in Breast Cancer

#DrugCompanyPhaseTrials

Quercetin

Adenocard

Lexiscan

Duragesic

Sporanox

SSebela Pharmaceuticals Development LLC

Ablavar

LLantheus Medical Imaging

Tc99m Sestamibi

MM.D. Anderson Cancer Center

Naltrexone/bupropion

Motexafin Gadolinium

PPharmacyclics LLC.

4SCAR T Cells

SShenzhen Geno-Immune Medical Institute

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q4 2026

PreclinicalActive, not recruiting

Mild Cognitive Impairment

NCT04785300

Q1 2028

Phase 2/3Recruiting

T Cells

NCT05653258

Q3 2028

Phase 1Recruiting

Glioma

NCT07025226

Phase 1Recruiting

Dyskeratosis Congenita

NCT07628972

Q2 2029

Phase 1Recruiting

Ptosis

NCT07433621

Clinical

Trials by Indication[1]

COVID-192 trials

The Study of Quadruple Therapy Zinc, Quercetin, Bromelain and Vitamin C on the Clinical Outcomes of Patients Infected With COVID-19

Unknown status·MMinistry of Health, Saudi Arabia·Phase 4·NCT04468139·60 enrolled

The Effectiveness of Phytotherapy in SARS-COV2(COVID-19)

Completed·UUnknown Sponsor·Phase 1·NCT04851821·80 enrolled

Function1 trial

Can Quercetin Increase Claudin-4 and Improve Esophageal Barrier Function in GERD?

Completed·UUniversity of North Carolina, Chapel Hill·Phase 1·NCT02226484·26 enrolled

Periodontitis1 trial

Effect of Quercetin in Treatment of Periodontitis

Unknown status·—·Phase 1·NCT05928546·20 enrolled

Neuropathic Pain1 trial

Trial of Quercetin in the Treatment and Prevention of Chemotherapy-induced Neuropathic Pain in Cancer Patients

Withdrawn·MM.D. Anderson Cancer Center·Phase 1·NCT02989129

Alzheimer's Disease1 trial

Safety and Feasibility of Dasatinib and Quercetin in Adults at Risk for Alzheimer's Disease

Completed·LLewis Lipsitz·Phase 1/2·NCT05422885·15 enrolled

25 more indications

Postmenopausal Women1 trial

Sirtuin-1 and Advanced Glycation End-products in Postmenopausal Women With Coronary Disease

Unknown status·IInCor Heart Institute·Phase 3·NCT03943459·60 enrolled

COPD1 trial

Biological Effects of Quercetin in COPD

Unknown status·TTemple University·Phase 1/2·NCT03989271·29 enrolled

Chronic Obstructive Pulmonary Disease1 trial

Beneficial Effects of Quercetin in Chronic Obstructive Pulmonary Disease (COPD)

Completed·UUniversity of Michigan·Phase 1·NCT01708278·9 enrolled

Surgery1 trial

Quercetin in Coronary Artery By-pass Surgery

Active, not recruiting·MMontreal Heart Institute·Phase 2·NCT04907253·100 enrolled

T Cells1 trial

Single Nuclei RNA-seq to Map Adipose Cellular Populations and Senescent Cells in Older Subjects

Recruiting·—·Phase 2/3·NCT05653258·160 enrolled

Polycystic Ovary Syndrome1 trial

Effects of Adding Quercetin or Alpha Lipoic Acid to Usual Care on Symptoms and Blood Markers in Iraqi Women With Polycystic Ovary Syndrome

Recruiting·—·Phase 2·NCT07182526·150 enrolled

Prostate Cancer1 trial

Effect of Quercetin on Green Tea Polyphenol Uptake in Prostate Tissue From Patients With Prostate Cancer Undergoing Surgery

Completed·JJonsson Comprehensive Cancer Center·Phase 1·NCT01912820·32 enrolled

Pain1 trial

Quercetin Effect on Post-ceserean Pain

Completed·FFuture University in Egypt·Phase 3·NCT06650891·80 enrolled

Oral Lichen Planus1 trial

Therapeutic Effect of Quercetin and the Current Treatment of Erosive and Atrophic Oral Lichen Planus

Unknown status·MMashhad University of Medical Sciences·Phase 1·NCT01375101·30 enrolled

Ptosis1 trial

Quercetin in Patients With XIAP (X-linked Inhibitor of Apoptosis) Deficiency

Recruiting·—·Phase 1·NCT07433621·12 enrolled

Humans1 trial

Targeting Cellular Senescence With Senolytics to Improve Skeletal Health in Older Humans

Completed·—·Phase 2·NCT04313634·74 enrolled

Breast Cancer1 trial

Dasatinib Combined With Quercetin to Reverse Chemo Resistance in Triple Negative Breast Cancer

Recruiting·FFudan University·Phase 2·NCT06355037·10 enrolled

SARS-CoV-21 trial

Quercetin In The Treatment Of SARS-COV 2

Completed·UUnknown Sponsor·Phase 1·NCT04853199·200 enrolled

Colon Cancer1 trial

Sulindac and Plant Compounds in Preventing Colon Cancer

Terminated·UUniversity of Medicine and Dentistry of New Jersey·N/A·NCT00003365

Oral Mucositis1 trial

Effect of Quercetin in Prevention and Treatment of Oral Mucositis

Completed·MMashhad University of Medical Sciences·Phase 1/2·NCT01732393·20 enrolled

Phase II1 trial

Biological Effects of Quercetin in COPD Phase II

Recruiting·TTemple University·Phase 2·NCT06003270·30 enrolled

Hematopoietic Stem Cell Transplant1 trial

Hematopoietic Stem Cell Transplant Survivors Study

Completed·MMayo Clinic·Phase 1·NCT02652052·9 enrolled

Chronic Kidney Disease1 trial

Senescence in Chronic Kidney Disease

Enrolling by invitation·MMayo Clinic·Phase 2·NCT02848131·30 enrolled

Estrogen Deficiency1 trial

Quercetin for Cardio-Skeletal Muscle Health and Estrogen Deficiency

Withdrawn·WWake Forest University Health Sciences·Phase 4·NCT04258410

Mental Disorders1 trial

Dasatinib Plus Quercetin for Accelerated Aging in Mental Disorders

Active, not recruiting·WWashington University School of Medicine·Phase 2·NCT05838560·40 enrolled

Glioma1 trial

MC230715 Pilot Study of the Mechanistic Feedback From CNS Tumors With Latent Residual Disease to Guide Individualized Therapies

Recruiting·MMayo Clinic·Phase 1·NCT07025226·30 enrolled

HIV1 trial

Improving Physical Ability and Cellular Senescence Elimination in HIV

Completed·NNational Institute of Allergy and Infectious Diseases (NIAID)·Phase 2·NCT07144293·82 enrolled

Dyskeratosis Congenita1 trial

Pilot Study of Quercetin Patients With Dyskeratosis Congenita/Telomere Biology Disorders

Recruiting·CChildren's Hospital Medical Center, Cincinnati·Phase 1·NCT07628972·12 enrolled

Recurrent Multiple Myeloma1 trial

DART: Phase II Study of Dasatinib and Quercetin in Patients With Relapsed, Refractory Multiple Myeloma Receiving CAR-T Therapy

Recruiting·MMayo Clinic·Phase 2·NCT06940297·44 enrolled

Mild Cognitive Impairment1 trial

ALSENLITE: An Open-Label Pilot Study of Senolytics for Alzheimer's Disease

Active, not recruiting·MMayo Clinic·Preclinical·NCT04785300·20 enrolled

Sources

References

[1]
ClinicalTrials.gov — 31 trial records for Quercetin. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — Quercetin compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for Quercetin. EMBL-EBI & Wellcome Sanger Institute.
[4]
SEC EDGAR — Mayo Clinic company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[2]
Highest Phase: Phase 3[1]
Company: MMayo Clinic

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