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Adenocard

(Adenosine)

ApprovedSmall molecule

Adenosine is used to help diagnose heart problems by temporarily slowing down your heart rate during a stress test, and it can also be used to treat certain abnormal heart rhythms by helping restore a normal heartbeat.[2] Adenocard is currently approved and in use across 27 indications[4].[1]

Adenocard is one of 465 small molecule programs targeting Hypertrophic Cardiomyopathy. It is currently in Approved.

27

Indications

59

Total Trials

8

Active Trials

464

Competitors

2

FDA Applications

NDA/BLA/ANDA regulatory filings

Pipeline

Status by Indication[4][1]

Indication

Hypertrophic CardiomyopathyTerminated

Supraventricular TachycardiaActive, not recruiting

Paroxysmal TachycardiaActive, not recruiting

Wolff-Parkinson-White SyndromeActive, not recruiting

Cardiovascular DiseaseActive, not recruiting

Chronic Lymphocytic LeukemiaApproved

LeukemiaApproved

ST Elevation Myocardial InfarctionApproved

ImmunodeficiencyApproved

ObesityActive, not recruiting

Hypertrophic CardiomyopathyApproved

Terminated

Supraventricular TachycardiaPreclinical

Active, not recruiting

Paroxysmal TachycardiaApproved

Active, not recruiting

Wolff-Parkinson-White SyndromeApproved

Active, not recruiting

Cardiovascular DiseaseApproved

Active, not recruiting

Chronic Lymphocytic LeukemiaApproved

Approved

LeukemiaApproved

Approved

ST Elevation Myocardial InfarctionApproved

Approved

ImmunodeficiencyApproved

Approved

ObesityPreclinical

Active, not recruiting

Showing 10 of 24 indications

Competition

Competitive Landscape

744 competitors in Breast Cancer

#DrugCompanyPhaseTrials

Adenocard

Lexiscan

Voltaren

Zolymbus

Blenoxane

Bristol-Myers Squibb

Methylthioninium Chloride

PProvepharm SAS

MS Contin

HHikma Pharmaceuticals LLC

Duragesic-100

MS Contin

HHikma Pharmaceuticals LLC

Spravato

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q4 2026

Post-ApprovalRecruiting

Treatment

NCT06993038

ApprovedRecruiting

Chronic Coronary Syndrome

NCT06578234

Q1 2027

Phase 1Recruiting

MRI Scan

NCT04600115

Q4 2027

ApprovedRecruiting

Premature Ventricular Contraction (PVC)

NCT03218137

Q4 2028

Post-ApprovalRecruiting

Treatment

NCT04666454

PreclinicalActive, not recruiting

Breast Cancer

NCT05309655

Clinical

Trials by Indication[1]

Treatment3 trials

Adrenaline for the Treatment of No-Reflow in Normotensive Patients

Completed·NNational Institute of Cardiovascular Diseases, Pakistan·Phase 4·NCT04699110·201 enrolled

Adenosine vs Diltiazem for Treatment of SVT in the ED

Recruiting·—·Phase 4·NCT06993038·20 enrolled

BROKEN-SWEDEHEART- Optimized Pharmacological Treatment for Broken Heart (Takotsubo) Syndrome.

Recruiting·VVastra Gotaland Region·Phase 4·NCT04666454·1,000 enrolled

Ischemia3 trials

Efficacy and Safety Study of Binodenoson in Assessing Cardiac Ischemia

Completed· Pfizer logo

Pfizer·Phase 3·NCT00944294·419 enrolled

Efficacy and Safety Study of Binodenoson in Assessing Cardiac Ischemia

Completed· Pfizer logo

Pfizer·Phase 3·NCT00944970·578 enrolled

Adenosine Receptors Influence Ischemia-Reperfusion Injury

Suspended·RRadboud University Medical Center·N/A·NCT00184847·8 enrolled

Imaging3 trials

ADVANCE MPI 1: Study of Regadenoson Versus Adenoscan® in Patients Undergoing Myocardial Perfusion Imaging (MPI)

Completed· Gilead logo

Gilead·Phase 3·NCT00208299·1,231 enrolled

Comparison of Quantitative MRI Perfusion Methods With Quantitative PET Perfusion Imaging

Withdrawn·UUniversity of Utah·N/A·NCT02608944

ADVANCE MPI 2: Study of Regadenoson Versus Adenoscan® in Patients Undergoing Myocardial Perfusion Imaging (MPI)

Completed· Gilead logo

Gilead·Phase 3·NCT00208312·787 enrolled

Necrosis2 trials

Prophylactic Intra-coronary Adenosine to Prevent Post Coronary Artery Stenting Myonecrosis

Terminated·OOttawa Heart Institute Research Corporation·Phase 3·NCT00612521·200 enrolled

Intracoronary Adenosine Administration to Prevent Periprocedural Myonecrosis in Elective Coronary Angioplasty

Completed·AAzienda Ospedaliero Universitaria Maggiore della Carita·Phase 3·NCT01148147·260 enrolled

CAR2 trials

Adenosine Cardioplegia; Improved Cardioprotection?

Completed·UUniversity Hospital of North Norway·Phase 1/2·NCT01123525·60 enrolled

Adenosine as an Adjunct to Blood Cardioplegia

Unknown status·—·Phase 2·NCT02681913·100 enrolled

40 more indications

ESS2 trials

Role of Adenosine in the Control of Choroidal Blood Flow During Changes in Ocular Perfusion Pressure.

Completed·MMedical University of Vienna·N/A·NCT00712764·20 enrolled

A Dose Titration Study to Assess the Effects of SAR407899 in Patients With MVA and/or Persistent Stable Angina Despite Angiographically Successful PCI

Terminated· Sanofi logo

Sanofi·Phase 2·NCT03236311·10 enrolled

Acute Myocardial Infarction2 trials

Adenosine's Effect on STunning Resolution in Acute Myocardial Infarction

Withdrawn·VVastra Gotaland Region·Phase 3·NCT05014061

THE REOPEN-AMI STUDY - Intracoronary Nitroprusside Versus Adenosine in Acute Myocardial Infarction

Completed·—·Phase 2/3·NCT00590070·240 enrolled

Breast Cancer2 trials

Stress Test in Detecting Heart Damage in Premenopausal Women With Stage I-III Breast Cancer

Completed·WWake Forest University Health Sciences··NCT03505736·25 enrolled

The Cardiac Outcomes With Near-Complete Estrogen Deprivation (CROWN) Study

Active, not recruiting·DDuke University·Preclinical·NCT05309655·90 enrolled

Supraventricular tachycardia1 trial

Adenosine Versus Verapamil for Management of Supraventricular Tachycardia Post- Coronary Artery Bypass Grafting

Completed·—·N/A·NCT04203368·268 enrolled

Conditioning1 trial

Salvage: Postconditioning With Adenosine for STEMI

Unknown status·UUniversity Hospital, Gasthuisberg·Phase 2·NCT00284323·100 enrolled

TIA1 trial

Adenosine vs. Diltiazem

Completed·HHaseki Training and Research Hospital·Phase 4·NCT07456423·140 enrolled

Adjuvant1 trial

Adenosine and Magnesium Sulphate as Adjuvants for PECS Block.

Completed·MMenoufia University·N/A·NCT03344679·90 enrolled

Pediatric1 trial

Analysis of Adenosine on Sinus and Atrioventricular Nodal Conduction in the Pediatric Transplanted Heart

Completed·—·Phase 1·NCT02462941·80 enrolled

Perioperative Pain1 trial

Dose-Response of Adenosine for Perioperative Pain

Completed·XXsira Pharmaceuticals·Phase 2·NCT00298636·160 enrolled

Pilot Study1 trial

Study on Reflex Response During Temporary Stimulation and Inhibition of Chemoreceptors of Carotid Bodies - a Pilot Study

Completed·NNoblewell·N/A·NCT01939912·10 enrolled

Paroxysmal atrial fibrillation1 trial

Adenosine to Assess Complete Conduction Block During Catheter Ablation of Paroxysmal Atrial Fibrillation

Completed·UUniversity of Michigan·Phase 2·NCT03032965·131 enrolled

Acute Respiratory Distress Syndrome1 trial

The ARCTIC Trial: Aerosolized Inhaled Adenosine Treatment in Patients With Acute Respiratory Distress Syndrome (ARDS) Caused by COVID-19

Withdrawn·UUniversity of Florida·Phase 2·NCT04588441

Ventricular Tachycardia1 trial

A Trial to Compare American Heart Association (AHA) and Simple (SIM)Method to Give Adenosine to Treat Supra-ventricular Tachycardia (SVT)

Completed·UUniversity of Pretoria·Phase 3·NCT04392362·30 enrolled

ISS1 trial

Adenosine and A2A Receptors in Human Brown Adipose Tissue

Completed·TTurku University Hospital·N/A·NCT03327168·11 enrolled

Dexmedetomidine1 trial

Dexmedetomidine and Adenosine: Therapeutic Use for SVT

Completed·UUniversity of Pittsburgh·N/A·NCT01495481·22 enrolled

Vasodilation1 trial

Pyridoxine, P2 Receptor Antagonism, and ATP-mediated Vasodilation in Young Adults

Completed·—·Phase 1·NCT03738943·9 enrolled

Cytokines1 trial

Role of Adenosine in the Release of VEGF and Cytokines

Terminated·VVanderbilt University·Phase 1·NCT00580905·8 enrolled

Neuropathic Pain1 trial

Clonidine Versus Adenosine to Treat Neuropathic Pain

Completed·WWake Forest University Health Sciences·Phase 2·NCT00349921·24 enrolled

Headache1 trial

The Effect of Adenosine on Cranial Hemodynamic, Headache and Migraine Induction Properties.

Completed·DDanish Headache Center·N/A·NCT04577443·18 enrolled

MPA1 trial

CONTRAST (Can cONTrast Injection Better Approximate FFR compAred to Pure reSTing Physiology?)

Completed·TThe University of Texas Health Science Center, Houston··NCT02184117·763 enrolled

Type 2 Diabetes Mellitus1 trial

Endothelial and Metabolic Effects of Glucagon-like Peptide-1 (GLP-1) in Coronary Circulation in Patients With Type 2 Diabetes Mellitus

Completed·UUniversity Hospital, Gentofte, Copenhagen·N/A·NCT00923962·35 enrolled

Percutaneous Coronary Intervention1 trial

Myocardial Protection With Adenosine During Primary Percutaneous Coronary Intervention in Pts With STEMI

Completed·DDavid Garcia-Dorado·Phase 3·NCT00781404·201 enrolled

Coronary Microvascular Dysfunction1 trial

A Single Center Diagnostic, Cross-sectional Study of Coronary Microvascular Dysfunction

Active, not recruiting·NNYU Langone Health·N/A·NCT03537586·206 enrolled

Magnetic Resonance Imaging1 trial

Assessment of Oxygen Changes in the Heart With Cardio-vascular Magnetic Resonance Imaging

Completed·UUniversity of Calgary·Phase 1·NCT00693758·100 enrolled

Heart Disease1 trial

Comprehensive Evaluation of Ischemic Heart Disease Using MRI

Completed·NNorthwestern University·Phase 2/3·NCT01234870·40 enrolled

Chest pain1 trial

Blood Markers for Inflammation and Coronary Artery Vasoreactivity Testing in Patients With Chest Pain and Normal Coronary Arteries

Unknown status·SSt George's Healthcare NHS Trust·N/A·NCT01162824·50 enrolled

Liver1 trial

AMP as a Better Delivery System of Adenosine

Terminated·VVanderbilt University Medical Center·Phase 1·NCT00179010·13 enrolled

Prevention1 trial

Prevention of Liver Damage During Liver Surgery

Unknown status·LLudwig-Maximilians - University of Munich·Phase 1/2·NCT00845689

Heart Transplant1 trial

Coronary Artery Vasculopathy in Pediatric Heart Transplant Patients

Completed·BBryan Goldstein·Phase 3·NCT03231371·22 enrolled

Paroxysmal supraventricular tachycardia1 trial

Efficacy of Adenosine as Compared to Verapamil in Paroxysmal Supraventricular Tachycardia (pSVT) Patients

Recruiting·RRashid Latif Medical College·Phase 3·NCT06717685·210 enrolled

Stress1 trial

Myocardial Blood Flow by PET and N-13 Ammonia During Regadenoson vs Adenosine Stress

Completed·MMayo Clinic·N/A·NCT01370265·12 enrolled

Injury1 trial

Ischemic Injury and Ischemic Preconditioning in Diabetes

Completed·RRadboud University Medical Center··NCT00184821·20 enrolled

Impairment1 trial

Adenosin to Rapidly Reverse Left Ventricle Impairment in Takotsubo Syndrome

Terminated·UUniversity Hospital of Ferrara·Phase 2·NCT02867878·5 enrolled

Hyperemia1 trial

Comparison of Intravenous Adenosine Infusion With Regadenoson Bolus for Inducing Maximal Coronary Hyperemia

Completed·SSt. Louis University·Phase 1·NCT01161121·46 enrolled

Myocardial Protection1 trial

Myocardial Protection With Adenosine Preconditioning

Completed·XXijing Hospital·Phase 1/2·NCT00881686·238 enrolled

Chronic Coronary Syndrome1 trial

Hyperemic mYocardial Perfusion by adEnosine at diffeRent Doses

Recruiting·RRegion Skane·Approved·NCT06578234·180 enrolled

MRI Scan1 trial

New MRI Methods Applied to Heart Failure With Preserved Ejection Fraction (HFpEF)

Recruiting·UUniversity of Utah·Phase 1·NCT04600115·100 enrolled

Premature Ventricular Contraction (PVC)1 trial

Use of Adenosine to Determine the Electrophysiological Mechanism of Premature Ventricular Contractions

Recruiting·WWeill Medical College of Cornell University·Approved·NCT03218137·100 enrolled

Hypertrophic Cardiomyopathy1 trial

Microvascular Dysfunction in Nonischemic Cardiomyopathy: Insights From CMR Assessment of Coronary Flow Reserve

Terminated·—·Approved·NCT03249272·31 enrolled

Unspecified4 trials

Effects of Body Mass Index on the Hyperemic Response to Regadenoson

Completed·UUniversity of Utah·N/A·NCT00859833·30 enrolled

Regadenoson and Adenosine

Completed·LLokien van Nunen·Phase 3·NCT01809743·100 enrolled

Adenosine Contrast CorrELations in Evaluating RevAscularizaTION

Completed·—·Phase 4·NCT03557385·201 enrolled

Show 1 more trial

Effect of Ticagrelor vs. Dipyridamole on Adenosine Uptake

Completed·VVanderbilt University·Phase 1·NCT01690884·28 enrolled

Regulatory

FDA Approval Timeline[5]

Oct 30, 1989

ADENOCARD

NDA NDA019937

May 18, 1995

ADENOSCAN

NDA NDA020059

Sources

References

[1]
ClinicalTrials.gov — 59 trial records for Adenosine. U.S. National Library of Medicine, National Institutes of Health.
[2]
MedlinePlus Drug Information — Adenocard drug information. U.S. National Library of Medicine, National Institutes of Health.
[3]
ChEMBL — Adenosine compound record. European Bioinformatics Institute (EMBL-EBI).
[4]
Open Targets Platform — Drug–disease associations for Adenosine. EMBL-EBI & Wellcome Sanger Institute.
[5]
OpenFDA — FDA approval records (NDA NDA020059). U.S. Food & Drug Administration.
[6]
SEC EDGAR — Astellas company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Mechanism of Action: Adenosine Receptor Agonist[3]
Modality: Small molecule[3]
Highest Phase: Approved[1]
Company: Astellas

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