Cadonilimab

Phase 3Monoclonal antibody

SShanghai Pharmaceuticals Holding Co., Ltd

It is used to treat severe cases of a serious inflammatory condition called cytokine release syndrome, which can occur as a severe side effect when certain cancer immunotherapy treatments activate the immune system too strongly.[1] Cadonilimab is currently being investigated across 41 indications[3], with its most advanced program in Phase 3.[1]

Cadonilimab is one of 738 small molecule programs targeting Gastroesophageal Junction Adenocarcinoma. It is currently in Phase 3.

Indications

Total Trials

Active Trials

737

Competitors

Pipeline

Status by Indication[3][1]

Indication

Gastroesophageal Junction AdenocarcinomaRecruiting

Esophageal Squamous Cell CarcinomaRecruiting

Nasopharyngeal CarcinomaActive, not recruiting

Lung CancerNot yet recruiting

Esophageal CancerActive, not recruiting

Cervical AdenocarcinomaRecruiting

Portal HypertensionRecruiting

AdenocarcinomaRecruiting

Metastatic MelanomaNot yet recruiting

Intrahepatic CholangiocarcinomaNot yet recruiting

Gastroesophageal Junction AdenocarcinomaPhase 3

Recruiting

Esophageal Squamous Cell CarcinomaPhase 2

Recruiting

Nasopharyngeal CarcinomaPhase 3

Active, not recruiting

Lung CancerPhase 2

Not yet recruiting

Esophageal CancerPhase 2

Active, not recruiting

Cervical AdenocarcinomaPhase 2

Recruiting

Portal HypertensionPhase 2

Recruiting

AdenocarcinomaPhase 3

Recruiting

Metastatic MelanomaPhase 2

Not yet recruiting

Intrahepatic CholangiocarcinomaPhase 2

Not yet recruiting

Showing 10 of 41 indications

Competition

Competitive Landscape

706 competitors in Breast Cancer

#DrugCompanyPhaseTrials

Cadonilimab

SShanghai Pharmaceuticals Holding Co., Ltd

Phase 3

1 2

Lexiscan

Astellas

Preclinical

1 3

Voltaren

Novartis

Preclinical

1 4

Blenoxane

Bristol-Myers Squibb

Preclinical

1 5

MS Contin

HHikma Pharmaceuticals LLC

Preclinical

3 6

Duragesic-100

CCephalon

Preclinical

2 7

MS Contin

HHikma Pharmaceuticals LLC

Preclinical

2 8

Spravato

WWim Janssens

Preclinical

2 9

Sporanox

SSebela Pharmaceuticals Development LLC

Preclinical

1 10

Tricor

JJagotec

Preclinical

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q4 2026

Recruiting

Cervical Cancer

NCT06140589

Phase 2Not yet recruiting

Metastatic

NCT05732662

Phase 2Recruiting

Non-Small Cell Lung Cancer

NCT06467500

PreclinicalRecruiting

Solid Tumor

NCT05944224

Q1 2027

N/ARecruiting

Hepatocellular Carcinoma

NCT06265350

Phase 2Recruiting

Fruquintinib

NCT06168786

Clinical

Trials by Indication[1]

Hepatocellular Carcinoma8 trials

Cadonilimab in Combination With Lenvatinib and Hepatic Arterial Infusion Chemotherapy (HAIC) for the Treatment of Unresectable Hepatocellular Carcinoma

Recruiting·HHunan Cancer Hospital·Phase 2·NCT06406634·30 enrolled

Cryoablation Combined With Cardonilizumab and Bevacizumab in Hepatocellular Carcinoma With Pulmonary Metastases

Recruiting·SSun Yat-sen University·N/A·NCT06265350·80 enrolled

A Study of AK112 in Patients With Advanced Hepatocellular Carcinoma (HCC)

Recruiting·AAkeso·Phase 1/2·NCT06530251·280 enrolled

Show 5 more trials

Efficacy and Safety of SBRT Combined With Cardonilizumab and Lenvastinib in the Treatment of Unresectable Hepatocellular Carcinoma With Portal Vein Tumor Thrombus

Unknown status·FFirst Affiliated Hospital of Guangxi Medical University·Phase 1/2·NCT06040177·30 enrolled

A Study Evaluating Cadonilimab Injection in Combination With Regorafenib for the Advanced Hepatocellular Carcinoma

Active, not recruiting·TTianjin Medical University Cancer Institute and Hospital·Phase 1·NCT05644379·30 enrolled

Cadonilimab in Combination With Ramucirumab for the Treatment of Advanced Hepatocellular Carcinoma That Has Failed at Systemic Therapy

Unknown status·TTianjin Medical University Cancer Institute and Hospital·Phase 1·NCT05856864·30 enrolled

A Prospective Study of Cadonilimab in Hepatocellular Carcinoma After Radical Surgery With High Risk of Recurrence

Terminated·GGuangxi Medical University·Phase 2·NCT06851104·45 enrolled

AK104 Combining With TACE for Resectable Hepatocellular Carcinoma (MORNING)

Unknown status·SSun Yat-sen University·Phase 2·NCT05578430·54 enrolled

Cervical Cancer6 trials

Neoadjuvant Chemoimmunotherapy and Extrafascial Hysterectomy for IB2 Cervical Cancer

Recruiting·TTongji Hospital·Phase 2·NCT06289751·50 enrolled

Cadonilimab Plus Anlotinib for R/M/P Cervical Cancer

Recruiting·ZZhongnan Hospital·Phase 2·NCT05817214·35 enrolled

Exploring the Efficacy, Safety and Cost-effectiveness Analysis of Cadonilimab in the Treatment of Cervical Cancer

Recruiting·FFujian Cancer Hospital··NCT06140589·200 enrolled

Show 3 more trials

Cadonilimab Plus Nab -Paclitaxel for Patients With Recurrent, or Metastatic Cervical Cancer Resistant to Immune Checkpoint Inhibitors

Not yet recruiting·WWomen's Hospital School Of Medicine Zhejiang University·Phase 2·NCT05824494·58 enrolled

A Prospective Real-world Study of Cadonilimab in Patients With Recurrent or Metastatic Cervical Cancer

Not yet recruiting·GGang Chen (101199)··NCT06155422·670 enrolled

Induction Chemotherapy Plus Cadonilimab for Locally Advanced Cervical Cancer

Recruiting·SSun Yat-Sen Memorial Hospital of Sun Yat-Sen University·Phase 2·NCT06511726·29 enrolled

Non-Small Cell Lung Cancer5 trials

Study of Cadonilimab Combined With Bevacizumab and Chemotherapy for Advanced Nonsquamous Non-small Cell Lung Cancer Patients With Untreated Brain Metastases

Unknown status·SSecond Affiliated Hospital of Nanchang University·Phase 2·NCT05812534·36 enrolled

To Evaluate the Safety and Tolerability of Carbognilumab Combined With Chemotherapy as the First-line Treatment for Patients With KEAP1 Mutated Advanced or Postoperative Recurrent Non-small Cell Lung Cancer (NSCLC)

Recruiting·GGuangzhou Institute of Respiratory Disease·Phase 2·NCT06341660·30 enrolled

A Prospective, Open-label, Single-center, Single-arm Phase II Clinical Study of Cadonilimab (AK104) Combined With Monotherapy Chemotherapy in Patients With Advanced Non-small Cell Lung Cancer With Negative Driver Genes and Failed Immunotherapy

Recruiting·XXin-Hua Xu·Phase 2·NCT06467500·48 enrolled

Show 2 more trials

Cadonilimab in Patients (Pts) With Advanced Non-small Cell Lung Cancer (NSCLC)

Active, not recruiting·SShanghai Chest Hospital·Phase 1/2·NCT05816499·50 enrolled

A Single-arm Pilot Study of First-line Treatment With Carbognilumab Combined With Chemotherapy in Patients With STK11-mutated Advanced or Postoperative Recurrent Non-small Cell Lung Cancer

Recruiting·GGuangzhou Institute of Respiratory Disease·Phase 2·NCT06331650·30 enrolled

Nasopharyngeal Carcinoma4 trials

Cadonilimab (AK104) in the Treatment of Nasopharyngeal Carcinoma

Unknown status·UUnion Hospital, Tongji Medical College, Huazhong University of Science and Technology·Phase 2·NCT05790200·30 enrolled

TPC Combined With Cadonilimab VS. TPC Alone in Anti-PD-1 Resistant Recurrent or Metastatic Nasopharyngeal Carcinoma

Active, not recruiting·SSun Yat-sen University·Phase 3·NCT06664983·84 enrolled

Cadonilimab in the Treatment of Recurrent/Metastatic Nasopharyngeal Carcinoma

Not yet recruiting·GGuangxi Medical University·Phase 1/2·NCT05898256·20 enrolled

Show 1 more trial

Cadonilimab (PD-1/CTLA-4 Bispecific Blockade) and Chemoradiotherapy in Nasopharyngeal Carcinoma (GEMSTONE)

Active, not recruiting·SSun Yat-sen University·Phase 3·NCT05587374·490 enrolled

Gastric Cancer4 trials

RC48 Plus AK104 as First-line Treatment for HER2-overexpressing Advanced Gastric Cancer

Not yet recruiting·TThe First Affiliated Hospital of Zhengzhou University·Phase 2·NCT06492317·20 enrolled

Cadonilimab Combined With CapeOX Regimen in Perioperative Treatment of Resectable Locally Advanced Gastric Cancer

Unknown status·TTianjin Medical University Cancer Institute and Hospital·Phase 2·NCT05974059·20 enrolled

Neoadjuvant Cadonilimab Plus Chemotherapy for Locally Advanced Esophagogastric Junction and Gastric Cancer Trial

Not yet recruiting·NNanfang Hospital, Southern Medical University·Phase 2·NCT06310473·30 enrolled

Show 1 more trial

A Phase 2, Single-arm Study of Cadonilimab and FLOT Chemotherapy in Patients With Locally Advanced, Resectable Gastric or Gastroesophageal Junction (GEJ) Adenocarcinoma

Recruiting·MMemorial Sloan Kettering Cancer Center·Phase 2·NCT07631000·37 enrolled

47 more indications

Gastroesophageal Junction Adenocarcinoma3 trials

Cadonilimab Combination With Chemotherapy With or Without AK117 in Resectable Gastric or Gastroesophageal Junction Adenocarcinoma

Recruiting·AAkeso·Phase 2·NCT05960955·90 enrolled

A Study of AK104/Placebo Plus AK109/Placebo And Paclitaxel in Gastric or Gastroesophageal Junction Adenocarcinoma

Recruiting·AAkeso·Phase 3·NCT06341335·506 enrolled

DV Combined With Cadonilimab in Subjects With HER2-expressing Gastric Cancer and Gastroesophageal Junction Adenocarcinoma After Progression on First-line Therapy

Recruiting·RRemeGen Co., Ltd.·Phase 2/3·NCT06221748·90 enrolled

Endometrial Cancer3 trials

Study of Cadonilimab (AK104) Plus Lenvatinib in Patients With Advanced Endometrial Cancer

Active, not recruiting·SSun Yat-sen University·Phase 2·NCT05824481·32 enrolled

Cadonilimab (AK104) Plus Chemotherapy in Patients With Recurrent or Advanced Endometrial Cancer

Not yet recruiting·FFujian Cancer Hospital·Phase 2·NCT06066216·45 enrolled

A Study on the Safety and Efficacy of Cadonilimab Combined With Progestin in Fertility-Sparing Treatment for Endometrial Cancer

Not yet recruiting·SSun Yat-Sen Memorial Hospital of Sun Yat-Sen University·Phase 2·NCT07900256·10 enrolled

First-line Treatment3 trials

Cadonilimab Plus Chemotherapy as First-line Treatment for PD-L1 Negative NSCLC

Recruiting·SShanghai Pulmonary Hospital, Shanghai, China·Phase 2·NCT06424821·54 enrolled

AK104 in Combination With AK112 Plus Chemotherapy(SOX/XELOX) as First-line Treatment for Advanced G/GEJ Cancer

Recruiting·HHarbin Medical University·Phase 2·NCT06196697·50 enrolled

Cadonilimab Combination Regimen as First-line Treatment for HER2-expressing GC/GEJ Patients

Recruiting·ZZhejiang Cancer Hospital·Phase 1/2·NCT06650332·90 enrolled

Treatment3 trials

Vorolanib Combined With Cadonilimab in the Treatment of Untreated Advanced RCC Patients

Not yet recruiting·—·Phase 1/2·NCT06577961·37 enrolled

A Study Evaluating Cadonilimab Injection in Combination With Regorafenib for the Treatment of Biliary Systemic Tumours

Unknown status·TTianjin Medical University Cancer Institute and Hospital·Phase 1·NCT05644392·30 enrolled

Cadonilimab (AK104) With or Without CT as 2rd Line Treatment for ES-SCLC

Unknown status·—·Phase 2·NCT05901584·30 enrolled

Fruquintinib2 trials

Cadonilimab Combined With Fruquintinib and SBRT as Athird-line and Posterior Line Treatment in Patients With MSS CRC

Recruiting·HHuazhong University of Science and Technology·Phase 2·NCT06168786·40 enrolled

Cadonilimab Combined With Fruquintinib and SBRT as Athird-line and Posterior Line Treatment in Patients With MSS CRC

Recruiting·LLiu Huang·N/A·NCT06551207·80 enrolled

Esophageal Squamous Cell Carcinoma2 trials

Efficacy and Safety of Cadonilimab and Chemoradiotherapy in Unresectable Locally Advanced Esophageal Squamous Cell Carcinoma

Enrolling by invitation·FFirst Affiliated Hospital of Ningbo University·N/A·NCT06715501·20 enrolled

Perioperative Cadonilimab Combined With Neoadjuvant Chemotherapy in Resectable Esophageal Squamous Cell Carcinoma (ESCC)

Recruiting·AAkeso·Phase 2·NCT07263919·90 enrolled

Colorectal Cancer2 trials

Cadonilimab Plus FOLFOXIRI and Bevacizumab as First Line Therapy for Metastatic MSS Colorectal Cancer

Unknown status·FFujian Cancer Hospital·Phase 2·NCT05839470·20 enrolled

Cadonilimab in Locally Advanced MSI-H/dMMR Colorectal Cancer

Recruiting·—·Phase 2·NCT05815290·50 enrolled

Triple-Negative Breast Cancer2 trials

Study of Cadonilimab (AK104) Plus Eribulin vs. Eribulin Monotherapy for Recurrent or Metastatic Triple-negative Breast Cancer

Not yet recruiting·SShengjing Hospital·Phase 2·NCT06202313·128 enrolled

SBRT, Chemotherapy, and AK104 Neoadjuvant Therapy for Triple-negative Breast Cancer (TNBC)

Recruiting·UUnknown Sponsor·Phase 2·NCT06401005·51 enrolled

Cervical Adenocarcinoma1 trial

IN10018 With Nab-Paclitaxel and Cadonilimab for Metastatic or Recurrent Gastric-Type Cervical Adenocarcinoma: Phase 2 Trial

Recruiting·UUnion Hospital, Tongji Medical College, Huazhong University of Science and Technology·Phase 2·NCT06654011·25 enrolled

Adenocarcinoma1 trial

A Phase III Clinical Study of Cadonilimab Plus SOX as Perioperative Treatment for Patients With Resectable G/GEJ Adenocarcinoma

Recruiting·AAkeso·Phase 3·NCT07023315·760 enrolled

Metastatic Melanoma1 trial

Cadonilimab in Combination With Anlotinib in the Treatment of Locally Progressive or Metastatic Melanoma With First-Line Therapy Failure

Not yet recruiting·HHunan Cancer Hospital·Phase 2·NCT06327698·30 enrolled

Liver Cancer1 trial

Ligufalimab and Cadonilimab in Advanced Liver Cancers

Recruiting·UUniversity of Texas Southwestern Medical Center·Phase 2·NCT06789848·64 enrolled

Neoadjuvant Therapy1 trial

Cadonilimab Combination With Lenvatinib as Neoadjuvant Therapy for ccRCC

Completed·SSun Yat-sen University·Phase 2·NCT06138496·39 enrolled

Glioblastoma1 trial

Treatment of Recurrent Glioblastoma With Fractionated Radiotherapy Combined With Cadonilimab

Unknown status·SSecond Affiliated Hospital, School of Medicine, Zhejiang University·Phase 1·NCT05737368·11 enrolled

Metastatic1 trial

SBRT Combined With AK104 to Treatment Relapsed or Metastatic ESCC

Not yet recruiting·TThe First People's Hospital of Changzhou·Phase 2·NCT05732662·25 enrolled

Ovarian Cancer1 trial

SBRT-LDRT-Cadonilimab for Advanced Gastric, Colorectal and Ovarian Cancers With Peritoneal Metastases

Active, not recruiting·ZZhang Tao·Phase 1/2·NCT06940921·26 enrolled

Neoadjuvant Treatment1 trial

XELOX Combined With Cadonilimab Versus XELOX as Neoadjuvant Treatment for Locally Advanced, pMMR Rectal Cancer

Recruiting·—·Phase 2·NCT05815303·92 enrolled

Chemotherapy1 trial

Phase II Study of Ivonescimab and Cadonilimab in Combination with Chemotherapy in Patients with ES-SCLC

Recruiting·SSichuan University·Phase 2·NCT06769971·80 enrolled

Soft Tissue Sarcoma1 trial

A Trial of Cadonilimab With Adriamycin in Patients With Advanced Soft Tissue Sarcoma

Recruiting·UUnion Hospital, Tongji Medical College, Huazhong University of Science and Technology·Phase 2·NCT06367075·53 enrolled

Salivary Gland Carcinoma1 trial

Precision Treatment of Recurrent/Metastatic Salivary Gland Carcinoma Guided by Molecular Typing

Recruiting·PPeking Union Medical College·Phase 2·NCT06145308·39 enrolled

mRNA Vaccine1 trial

A Study of mRNA Vaccines AK154 Monotherapy or in Combination With AK104/AK112,and Sequential mFOLFIRINOX in Surgically Resected PDAC

Not yet recruiting·AAkeso·Phase 1·NCT06913218·60 enrolled

Endometrial Carcinoma1 trial

Cadonilimab With Chemoradiation for Recurrent and Oligometastatic Endometrial Carcinoma

Recruiting·SShandong Cancer Hospital and Institute·Phase 2·NCT06532539·30 enrolled

Ivonescimab1 trial

A Study of Ivonescimab in First-Line ES-SCLC

Recruiting·AAkeso·Phase 2·NCT07245446·180 enrolled

Systemic Therapy1 trial

AK104 and Low-dose Radiation in Recurrent/Metastatic HNSCC After Failure of First-line Systemic Therapy

Recruiting·FFudan University·Phase 2·NCT06494995·52 enrolled

Intrahepatic Cholangiocarcinoma1 trial

Phase II Clinical Study on the Efficacy and Safety of the Combination of Cadonilimab and Capecitabine in Adjuvant Therapy for Combined Hepatocellular Carcinoma and Intrahepatic Cholangiocarcinoma

Not yet recruiting·SShanghai Zhongshan Hospital·Phase 2·NCT07243951·75 enrolled

Refractory Malignant Solid Tumors1 trial

Stereotactic Body Radiotherapy Combined With Cadonilimab for Advanced Refractory Malignant Solid Tumors

Unknown status·PPeking University Third Hospital·Phase 1/2·NCT05915481·60 enrolled

Bladder Cancer1 trial

Cadonilimab Plus Nab-Paclitaxel for Recurrent or Metastatic Muscle Invasive Bladder Cancer

Unknown status·TTianjin Medical University Second Hospital·Phase 2·NCT06009848·20 enrolled

Locally Advanced1 trial

A Study of AK104 in Subjects With Unresectable Locally Advanced NSCLC

Recruiting·AAkeso·Phase 3·NCT06617416·560 enrolled

Microsatellite Instability1 trial

Neoadjuvant/Adjuvant AK104 in Microsatellite Instability-high or Mismatch Repair-deficient, Resectable Colon Cancer

Not yet recruiting·AAkeso·Phase 3·NCT07412613·386 enrolled

Locally-advanced Rectal Cancer1 trial

Neoadjuvant Cadonilimab Plus Chemotherapy Following Short-Course Radiotherapy in Locally Advanced Rectal Cancer

Completed·SShenzhen People's Hospital·Phase 2·NCT05792735·27 enrolled

Concurrent Chemoradiotherapy1 trial

Cadonilimab(AK104) Plus Concurrent Chemoradiotherapy in Patients With Locally Advanced, Unresectable, Stage III NSCLC

Active, not recruiting·FFudan University·Phase 2·NCT06448910·41 enrolled

Portal Hypertension1 trial

TIPS Plus Cadonilimab in Advanced HCC with Tumor Thrombosis-associated Portal Hypertension:a Prospective, Single-arm, Phase II Study

Recruiting·FFei Gao·Phase 2·NCT05882370·30 enrolled

Lung Cancer1 trial

Cadonilimab Monotherapy as Neoadjuvant Therapy for Resectable II-IIIA Squamous Cell Lung Cancer

Not yet recruiting·TThe First Hospital of Jilin University·Phase 2·NCT05784974·37 enrolled

Unknown status·XXuekui Liu·Phase 2·NCT06023875·30 enrolled

Esophageal Cancer1 trial

Combination of Cadonilimab and Chemoradiotherapy in Esophageal Cancer (EC-CRT-006)

Active, not recruiting·SSun Yat-sen University·Phase 2·NCT06143748·46 enrolled

Glioblastoma Multiforme1 trial

Biomarker-guided RAdiation-deferring Treatment in Younger GBM Patients (BRAid GBM) Pilot Study

Not yet recruiting·OOlivia Newton-John Cancer Research Institute·Phase 1·NCT07908147·12 enrolled

Carcinoma, Non-Small-Cell Lung1 trial

Cadonilimab (AK104) Plus Chemotherapy as First-line Treatment in Non-squamous Non-Small Cell Lung Cancer (NSCLC) Patients With Programmed Cell Death Ligand 1 (PD-L1) Negative：A Multi-center, Single-arm, Phase II Study

Active, not recruiting·QQian Chu·Phase 2·NCT06001151·49 enrolled

Leptomeningeal Metastasis1 trial

Intrathecal Administration of PD-1/CTLA-4 Bispecific Antibody Plus Pemetrexed in Patients With Leptomeningeal Metastasis From Solid Tumors: A Phase I/II Study

Active, not recruiting·GGuangzhou Medical University·Preclinical·NCT06762080·39 enrolled

Colorectal Carcinoma1 trial

FAPI-Guided Hypofractionated Radiotherapy Combined With Cadonilimab and Standard Second-Line Chemotherapy Versus Standard Second-Line Chemotherapy for Peritoneal Metastasis From Colorectal Cancer: A Multicenter, Randomized, Open-Label, Phase III Trial (TORHC-PM02)

Recruiting·FFudan University·Phase 3·NCT07815834·198 enrolled

Gastric / Gastroesophageal Junction Adenocarcinoma1 trial

A Randomized, Double-blind, Multi-regional Phase 3 Study of Cadonilimab Combined With Chemotherapy Versus Chemotherapy in Combination With or Without Nivolumab for the First-line Treatment of Participants With HER2-negative, Previously Untreated, Unresectable or Metastatic Gastric or Gastroesophageal Junction Adenocarcinoma

Recruiting·AAkeso·Phase 3·NCT07700979·900 enrolled

Resectable Hepatocellular Carcinoma1 trial

A Phase Ib Open-label, Randomized Trial Evaluating Neoadjuvant Ateganosine and Cadonilimab in Resectable Hepatocellular Carcinoma

Recruiting·UUniversity of Texas Southwestern Medical Center·Phase 1·NCT07446257·60 enrolled

Hepatocellular Carcinoma Non-resectable1 trial

A Prospective, Open-label, Single-arm, Phase 2 Study of Hepatic Arterial Infusion Chemotherapy Combined With Lenvatinib and Cadonilimab as Conversion Therapy for Initially Unresectable Hepatocellular Carcinoma

Recruiting·TTongji Hospital·Phase 2·NCT06187961·36 enrolled

Solid Tumor1 trial

A Randomized, Open-label, Phase Ib/IIa Clinical Study to Evaluate the Efficacy and Safety of SPH4336 Monotherapy or in Combination With Cadonilimab in Patients With Advanced Solid Tumors, Including Advanced Well Differentiated/Dedifferentiated Liposarcoma.

Recruiting·SShanghai Pharmaceuticals Holding Co., Ltd·Preclinical·NCT05944224·63 enrolled

Colorectal Cancer Stage IV1 trial

Cadonilimab (Bispecific Anti-PD-1/CTLA-4 Antibody) for PD-1/PD-L1 Blockade-refractory, Microsatellite Instability-high (MSI-H) or Mismatch Repair-deficient (dMMR), Advanced Colorectal Cancer: a Single Group, Multicenter, Phase 2 Trial

Active, not recruiting·SSun Yat-sen University·Preclinical·NCT05426005·28 enrolled

Unspecified1 trial

Cadonilimab Combined With RT in LACC Patients Ineligible for CCRT

Not yet recruiting·RRuijin Hospital·Phase 2·NCT07450963·45 enrolled

Sources

References

[1]
ClinicalTrials.gov — 86 trial records for Cadonilimab. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — Cadonilimab compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for Cadonilimab. EMBL-EBI & Wellcome Sanger Institute.
[4]
SEC EDGAR — Shanghai Pharmaceuticals Holding Co., Ltd company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Mechanism of Action: Programmed Cell Death Protein 1 Inhibitor; Cytotoxic T-Lymphocyte Protein 4 Inhibitor[2]
Modality: Monoclonal antibody[2]
Highest Phase: Phase 3[1]
Company: SShanghai Pharmaceuticals Holding Co., Ltd

Cadonilimab

Status by Indication[3][1]

Competitive Landscape

Expected Milestones

Q4 2026

Q1 2027

Trials by Indication[1]

Hepatocellular Carcinoma8 trials

Cervical Cancer6 trials

Non-Small Cell Lung Cancer5 trials

Nasopharyngeal Carcinoma4 trials

Gastric Cancer4 trials

Gastroesophageal Junction Adenocarcinoma3 trials

Endometrial Cancer3 trials

First-line Treatment3 trials

Treatment3 trials

Fruquintinib2 trials

Esophageal Squamous Cell Carcinoma2 trials

Colorectal Cancer2 trials

Triple-Negative Breast Cancer2 trials

Cervical Adenocarcinoma1 trial

Adenocarcinoma1 trial

Metastatic Melanoma1 trial

Liver Cancer1 trial

Neoadjuvant Therapy1 trial

Glioblastoma1 trial

Metastatic1 trial

Ovarian Cancer1 trial

Neoadjuvant Treatment1 trial

Chemotherapy1 trial

Soft Tissue Sarcoma1 trial

Salivary Gland Carcinoma1 trial

mRNA Vaccine1 trial

Endometrial Carcinoma1 trial

Ivonescimab1 trial

Systemic Therapy1 trial

Intrahepatic Cholangiocarcinoma1 trial

Refractory Malignant Solid Tumors1 trial

Bladder Cancer1 trial

Locally Advanced1 trial

Microsatellite Instability1 trial

Locally-advanced Rectal Cancer1 trial

Concurrent Chemoradiotherapy1 trial

Portal Hypertension1 trial

Lung Cancer1 trial

Breast Cancer1 trial

Radiotherapy1 trial

Head and Neck Squamous Cell Carcinoma1 trial

Esophageal Cancer1 trial

Glioblastoma Multiforme1 trial

Carcinoma, Non-Small-Cell Lung1 trial

Leptomeningeal Metastasis1 trial

Colorectal Carcinoma1 trial

Gastric / Gastroesophageal Junction Adenocarcinoma1 trial

Resectable Hepatocellular Carcinoma1 trial

Hepatocellular Carcinoma Non-resectable1 trial

Solid Tumor1 trial

Colorectal Cancer Stage IV1 trial

Unspecified1 trial

References

Drug Info

Quick Facts

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